| East | W | L | Pct | GB |
| Tampa Bay | 96 | 66 | .593 | -- |
| NY Yankees | 95 | 67 | .586 | 1.0 |
| Boston | 89 | 73 | .549 | 7.0 |
| Toronto | 85 | 77 | .525 | 11.0 |
| Baltimore | 66 | 96 | .407 | 30.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2010-04-05 | Shaun Marcum | R | 28 | L 4-5 | @ TEX | 1 | 65 | - | 7.0 | 2 | 3 | 3 | 1 | 1 | 6 | 93 | 36 | 57 | 61% | 0-0 | 3.86 | 0.43 |
| 2010-04-07 | Brian Tallet | L | 33 | W 7-4 | @ TEX | 1 | 32 | W | 6.2 | 4 | 4 | 2 | 2 | 3 | 6 | 93 | 37 | 56 | 60% | 1-0 | 2.57 | 1.00 |
| 2010-04-08 | Ricky Romero | L | 25 | W 3-1 | @ TEX | 1 | 30 | - | 7.0 | 5 | 1 | 1 | 0 | 2 | 4 | 108 | 40 | 68 | 63% | 0-0 | 1.29 | 1.00 |
| 2010-04-09 | Brandon Morrow | R | 26 | W 7-6 | @ BAL | 1 | 16 | - | 5.0 | 4 | 5 | 5 | 1 | 5 | 5 | 84 | 34 | 50 | 60% | 0-0 | 9.00 | 1.80 |
| 2010-04-10 | Dana Eveland | L | 26 | W 3-0 | @ BAL | 1 | 45 | W | 7.1 | 5 | 0 | 0 | 0 | 2 | 2 | 96 | 36 | 60 | 63% | 1-0 | 0.00 | 1.00 |
| 2010-04-11 | Shaun Marcum | R | 28 | W 5-2 | @ BAL | 2 | 66 | - | 6.0 | 8 | 2 | 2 | 0 | 1 | 5 | 99 | 36 | 63 | 64% | 0-0 | 3.46 | 0.92 |
| 2010-04-12 | Brian Tallet | L | 33 | W 7-8 | vs CHA | 2 | 33 | - | 6.0 | 8 | 6 | 6 | 2 | 2 | 3 | 101 | 42 | 59 | 58% | 1-0 | 5.54 | 1.31 |
| 2010-04-13 | Ricky Romero | L | 25 | L 4-2 | vs CHA | 2 | 31 | W | 8.0 | 1 | 2 | 2 | 1 | 2 | 12 | 101 | 36 | 65 | 64% | 1-0 | 1.80 | 0.67 |
| 2010-04-14 | Brandon Morrow | R | 26 | W 1-11 | vs CHA | 2 | 17 | L | 4.0 | 8 | 7 | 7 | 2 | 1 | 3 | 87 | 36 | 51 | 59% | 0-1 | 12.00 | 2.00 |
| 2010-04-15 | Dana Eveland | L | 26 | L 7-3 | vs CHA | 2 | 46 | W | 6.0 | 3 | 2 | 2 | 1 | 3 | 4 | 90 | 36 | 54 | 60% | 2-0 | 1.38 | 1.00 |
| 2010-04-16 | Shaun Marcum | R | 28 | W 5-7 | vs ANA | 3 | 67 | L | 7.0 | 7 | 4 | 4 | 1 | 1 | 6 | 105 | 38 | 67 | 64% | 0-1 | 4.05 | 1.00 |
| 2010-04-17 | Brian Tallet | L | 33 | W 3-6 | vs ANA | 3 | 34 | L | 5.0 | 5 | 4 | 4 | 2 | 1 | 3 | 86 | 33 | 53 | 62% | 1-1 | 6.00 | 1.28 |
| 2010-04-18 | Ricky Romero | L | 25 | W 1-3 | vs ANA | 3 | 32 | L | 8.0 | 5 | 1 | 1 | 0 | 2 | 6 | 110 | 45 | 65 | 59% | 1-1 | 1.57 | 0.74 |
| 2010-04-19 | Brandon Morrow | R | 26 | L 8-1 | vs KCA | 3 | 18 | W | 7.0 | 3 | 1 | 1 | 0 | 2 | 8 | 90 | 26 | 64 | 71% | 1-1 | 7.31 | 1.44 |
| 2010-04-20 | Dana Eveland | L | 26 | L 4-3 | vs KCA | 3 | 47 | - | 5.1 | 8 | 3 | 2 | 0 | 2 | 3 | 94 | 42 | 52 | 55% | 2-0 | 1.89 | 1.21 |
| 2010-04-21 | Shaun Marcum | R | 28 | W 3-4 | vs KCA | 4 | 68 | - | 7.0 | 6 | 3 | 3 | 1 | 1 | 6 | 104 | 39 | 65 | 63% | 0-1 | 4.00 | 1.00 |
| 2010-04-23 | Brett Cecil | L | 24 | W 6-5 | @ TBA | 1 | 18 | W | 6.2 | 6 | 4 | 4 | 2 | 1 | 8 | 96 | 35 | 61 | 64% | 1-0 | 5.14 | 1.00 |
| 2010-04-24 | Ricky Romero | L | 25 | L 3-9 | @ TBA | 4 | 33 | - | 7.0 | 6 | 2 | 2 | 1 | 3 | 3 | 109 | 49 | 60 | 55% | 1-1 | 1.80 | 0.87 |
| 2010-04-25 | Brandon Morrow | R | 26 | L 0-6 | @ TBA | 4 | 19 | L | 6.0 | 3 | 2 | 2 | 0 | 6 | 8 | 111 | 49 | 62 | 56% | 1-2 | 6.14 | 1.45 |
| 2010-04-26 | Dana Eveland | L | 26 | W 12-13 | vs BOS | 4 | 48 | - | 3.0 | 8 | 7 | 7 | 0 | 3 | 3 | 82 | 34 | 48 | 59% | 2-0 | 4.50 | 1.55 |
| 2010-04-27 | Shaun Marcum | R | 28 | W 1-2 | vs BOS | 5 | 69 | - | 7.0 | 4 | 1 | 1 | 0 | 3 | 5 | 103 | 39 | 64 | 62% | 0-1 | 3.44 | 1.00 |
| 2010-04-28 | Brett Cecil | L | 24 | W 0-2 | vs BOS | 2 | 19 | L | 6.0 | 5 | 1 | 1 | 0 | 1 | 3 | 97 | 39 | 58 | 60% | 1-1 | 3.46 | 1.00 |
| 2010-04-29 | Ricky Romero | L | 25 | L 6-3 | vs OAK | 5 | 34 | W | 6.0 | 4 | 3 | 3 | 0 | 4 | 6 | 103 | 45 | 58 | 56% | 2-1 | 2.25 | 0.94 |
| 2010-04-30 | Brandon Morrow | R | 26 | L 10-2 | vs OAK | 5 | 20 | W | 6.0 | 7 | 2 | 2 | 0 | 2 | 9 | 107 | 36 | 71 | 66% | 2-2 | 5.46 | 1.46 |
| 2010-05-01 | Dana Eveland | L | 27 | W 3-4 | vs OAK | 5 | 49 | L | 6.2 | 8 | 4 | 4 | 1 | 3 | 1 | 86 | 37 | 49 | 57% | 2-1 | 4.82 | 1.61 |
| 2010-05-02 | Shaun Marcum | R | 28 | L 9-3 | vs OAK | 6 | 70 | W | 6.1 | 6 | 1 | 1 | 0 | 4 | 6 | 105 | 36 | 69 | 66% | 1-1 | 3.15 | 1.10 |
| 2010-05-03 | Brett Cecil | L | 24 | W 5-1 | @ CLE | 3 | 20 | W | 8.0 | 1 | 1 | 1 | 0 | 2 | 10 | 111 | 44 | 67 | 60% | 2-1 | 2.57 | 0.76 |
| 2010-05-04 | Ricky Romero | L | 25 | W 8-5 | @ CLE | 6 | 35 | W | 6.0 | 9 | 5 | 5 | 0 | 2 | 9 | 109 | 44 | 65 | 60% | 3-1 | 3.00 | 1.07 |
| 2010-05-05 | Brandon Morrow | R | 26 | W 5-4 | @ CLE | 6 | 21 | - | 5.1 | 6 | 3 | 3 | 1 | 4 | 9 | 98 | 37 | 61 | 62% | 2-2 | 5.45 | 1.55 |
| 2010-05-06 | Dana Eveland | L | 27 | W 2-0 | @ CHA | 6 | 50 | W | 7.0 | 2 | 0 | 0 | 0 | 4 | 3 | 95 | 41 | 54 | 57% | 3-1 | 3.86 | 1.46 |
| 2010-05-07 | Shaun Marcum | R | 28 | W 7-4 | @ CHA | 7 | 71 | - | 7.2 | 6 | 3 | 3 | 2 | 0 | 2 | 109 | 44 | 65 | 60% | 1-1 | 3.19 | 1.04 |
| 2010-05-08 | Brett Cecil | L | 24 | L 3-7 | @ CHA | 4 | 21 | L | 5.1 | 7 | 3 | 3 | 1 | 3 | 3 | 105 | 43 | 62 | 59% | 2-2 | 3.12 | 1.00 |
| 2010-05-09 | Ricky Romero | L | 26 | W 9-7 | @ CHA | 7 | 36 | - | 5.1 | 8 | 4 | 4 | 0 | 5 | 7 | 116 | 47 | 69 | 59% | 3-1 | 3.45 | 1.23 |
| 2010-05-10 | Brandon Morrow | R | 26 | L 6-7 | @ BOS | 7 | 22 | L | 1.2 | 3 | 6 | 6 | 0 | 6 | 4 | 67 | 35 | 32 | 48% | 2-3 | 6.69 | 1.71 |
| 2010-05-11 | Dana Eveland | L | 27 | L 1-6 | @ BOS | 7 | 51 | L | 4.0 | 6 | 6 | 6 | 1 | 4 | 2 | 101 | 51 | 50 | 50% | 3-2 | 4.85 | 1.56 |
| 2010-05-12 | Shaun Marcum | R | 28 | W 3-2 | @ BOS | 8 | 72 | W | 7.0 | 2 | 0 | 0 | 0 | 1 | 6 | 102 | 37 | 65 | 64% | 2-1 | 2.78 | 0.96 |
| 2010-05-14 | Brett Cecil | L | 24 | L 16-10 | vs TEX | 5 | 22 | - | 2.0 | 8 | 8 | 8 | 1 | 2 | 2 | 47 | 21 | 26 | 55% | 2-2 | 5.46 | 1.29 |
| 2010-05-15 | Ricky Romero | L | 26 | L 6-0 | vs TEX | 8 | 37 | W | 9.0 | 5 | 0 | 0 | 0 | 1 | 12 | 116 | 35 | 81 | 70% | 4-1 | 2.89 | 1.14 |
| 2010-05-16 | Brandon Morrow | R | 26 | L 5-2 | vs TEX | 8 | 23 | W | 6.0 | 8 | 2 | 2 | 0 | 1 | 8 | 95 | 33 | 62 | 65% | 3-3 | 6.15 | 1.68 |
| 2010-05-17 | Dana Eveland | L | 27 | W 3-8 | vs MIN | 8 | 52 | L | 4.0 | 9 | 5 | 3 | 1 | 4 | 2 | 89 | 36 | 53 | 60% | 3-3 | 5.02 | 1.72 |
| 2010-05-18 | Shaun Marcum | R | 28 | L 11-2 | vs MIN | 9 | 73 | W | 7.0 | 5 | 1 | 1 | 0 | 2 | 3 | 104 | 38 | 66 | 63% | 3-1 | 2.61 | 0.97 |
| 2010-05-19 | Brett Cecil | L | 24 | W 3-2 | @ SEA | 6 | 23 | W | 6.1 | 7 | 2 | 2 | 0 | 1 | 4 | 99 | 35 | 64 | 65% | 3-2 | 5.03 | 1.29 |
| 2010-05-20 | Ricky Romero | L | 26 | L 3-4 | @ SEA | 9 | 38 | - | 6.2 | 4 | 1 | 1 | 0 | 3 | 5 | 99 | 43 | 56 | 57% | 4-1 | 2.71 | 1.13 |
| 2010-05-21 | Brandon Morrow | R | 26 | L 6-8 | @ ARI | 9 | 24 | L | 4.0 | 8 | 6 | 6 | 1 | 1 | 5 | 82 | 28 | 54 | 66% | 3-4 | 6.80 | 1.73 |
| 2010-05-22 | Dana Eveland | L | 27 | L 5-8 | @ ARI | 9 | 53 | L | 1.1 | 8 | 8 | 8 | 0 | 2 | 1 | 46 | 19 | 27 | 59% | 3-4 | 6.40 | 1.87 |
| 2010-05-23 | Shaun Marcum | R | 28 | W 12-4 | @ ARI | 10 | 74 | W | 5.0 | 6 | 3 | 3 | 0 | 1 | 8 | 102 | 36 | 66 | 65% | 4-1 | 2.82 | 1.00 |
| 2010-05-24 | Brett Cecil | L | 24 | W 6-0 | @ ANA | 7 | 24 | W | 7.1 | 2 | 0 | 0 | 0 | 2 | 3 | 109 | 41 | 68 | 62% | 4-2 | 4.07 | 1.14 |
| 2010-05-25 | Ricky Romero | L | 26 | L 3-8 | @ ANA | 10 | 39 | L | 5.1 | 11 | 7 | 7 | 1 | 3 | 8 | 93 | 34 | 59 | 63% | 4-2 | 3.44 | 1.25 |
| 2010-05-26 | Brandon Morrow | R | 26 | L 5-6 | @ ANA | 10 | 25 | - | 5.0 | 3 | 3 | 3 | 0 | 4 | 6 | 98 | 44 | 54 | 55% | 3-4 | 6.66 | 1.70 |
| 2010-05-28 | Shaun Marcum | R | 28 | L 5-0 | vs BAL | 11 | 75 | W | 6.0 | 6 | 0 | 0 | 0 | 2 | 7 | 105 | 39 | 66 | 63% | 5-1 | 2.59 | 1.03 |
| 2010-05-29 | Brett Cecil | L | 24 | L 5-2 | vs BAL | 8 | 25 | W | 8.0 | 4 | 2 | 2 | 0 | 0 | 7 | 96 | 26 | 70 | 73% | 5-2 | 3.78 | 1.04 |
| 2010-05-30 | Ricky Romero | L | 26 | L 6-1 | vs BAL | 11 | 40 | W | 9.0 | 6 | 1 | 1 | 0 | 2 | 7 | 100 | 36 | 64 | 64% | 5-2 | 3.16 | 1.21 |
| 2010-05-31 | Brandon Morrow | R | 26 | L 3-2 | vs TBA | 11 | 26 | W | 7.0 | 3 | 1 | 1 | 0 | 2 | 1 | 87 | 36 | 51 | 59% | 4-4 | 6.00 | 1.58 |
| 2010-06-01 | Brian Tallet | L | 33 | W 6-7 | vs TBA | 4 | 35 | - | 5.2 | 4 | 0 | 0 | 0 | 3 | 4 | 81 | 30 | 51 | 63% | 1-1 | 4.70 | 1.30 |
| 2010-06-02 | Shaun Marcum | R | 28 | W 3-7 | vs TBA | 12 | 76 | L | 8.1 | 10 | 5 | 4 | 0 | 0 | 2 | 112 | 38 | 74 | 66% | 5-2 | 2.78 | 1.05 |
| 2010-06-04 | Brett Cecil | L | 24 | L 6-1 | vs NYA | 9 | 26 | W | 8.0 | 5 | 1 | 1 | 0 | 1 | 5 | 105 | 35 | 70 | 67% | 6-2 | 3.41 | 1.00 |
| 2010-06-05 | Ricky Romero | L | 26 | L 3-2 | vs NYA | 12 | 41 | - | 8.0 | 5 | 2 | 2 | 1 | 4 | 7 | 105 | 44 | 61 | 58% | 5-2 | 3.07 | 1.20 |
| 2010-06-06 | Brandon Morrow | R | 26 | W 3-4 | vs NYA | 12 | 27 | - | 7.0 | 4 | 1 | 1 | 0 | 1 | 8 | 107 | 41 | 66 | 62% | 4-4 | 5.48 | 1.48 |
| 2010-06-08 | Brian Tallet | L | 33 | L 0-9 | @ TBA | 5 | 36 | L | 4.0 | 6 | 5 | 5 | 1 | 1 | 3 | 79 | 31 | 48 | 61% | 1-2 | 5.67 | 1.37 |
| 2010-06-09 | Shaun Marcum | R | 28 | L 1-10 | @ TBA | 13 | 77 | L | 4.0 | 10 | 7 | 7 | 1 | 1 | 3 | 71 | 25 | 46 | 65% | 5-3 | 3.39 | 1.13 |
| 2010-06-10 | Brett Cecil | L | 24 | W 3-2 | @ TBA | 10 | 27 | W | 6.2 | 3 | 1 | 1 | 1 | 3 | 2 | 117 | 47 | 70 | 60% | 7-2 | 3.23 | 1.00 |
| 2010-06-11 | Ricky Romero | L | 26 | L 3-5 | @ COL | 13 | 42 | L | 5.0 | 7 | 4 | 4 | 2 | 1 | 5 | 78 | 27 | 51 | 65% | 5-3 | 3.30 | 1.22 |
| 2010-06-12 | Brandon Morrow | R | 26 | L 0-1 | @ COL | 13 | 28 | L | 6.0 | 5 | 1 | 1 | 0 | 3 | 6 | 97 | 42 | 55 | 57% | 4-5 | 5.14 | 1.47 |
| 2010-06-13 | Jesse Litsch | R | 25 | L 3-10 | @ COL | 1 | 51 | L | 2.1 | 9 | 7 | 7 | 1 | 1 | 2 | 80 | 30 | 50 | 63% | 0-1 | 31.50 | 5.00 |
| 2010-06-14 | Shaun Marcum | R | 28 | W 6-3 | @ SDN | 14 | 78 | W | 7.0 | 6 | 3 | 2 | 2 | 0 | 2 | 91 | 25 | 66 | 73% | 6-3 | 3.33 | 1.11 |
| 2010-06-15 | Brett Cecil | L | 24 | L 2-8 | @ SDN | 11 | 28 | L | 6.0 | 7 | 5 | 5 | 1 | 2 | 4 | 107 | 38 | 69 | 64% | 7-3 | 3.60 | 1.04 |
| 2010-06-16 | Ricky Romero | L | 26 | W 7-1 | @ SDN | 14 | 43 | W | 6.0 | 5 | 1 | 0 | 0 | 3 | 5 | 112 | 39 | 73 | 65% | 6-3 | 3.09 | 1.23 |
| 2010-06-18 | Brandon Morrow | R | 26 | L 3-2 | vs SFN | 14 | 29 | - | 6.0 | 5 | 2 | 2 | 0 | 3 | 4 | 100 | 42 | 58 | 58% | 4-5 | 4.97 | 1.46 |
| 2010-06-19 | Jesse Litsch | R | 25 | L 3-0 | vs SFN | 2 | 52 | - | 7.0 | 3 | 0 | 0 | 0 | 0 | 3 | 94 | 37 | 57 | 61% | 0-1 | 7.00 | 1.44 |
| 2010-06-20 | Shaun Marcum | R | 29 | W 6-9 | vs SFN | 15 | 79 | - | 5.0 | 4 | 2 | 1 | 1 | 5 | 8 | 102 | 44 | 58 | 57% | 6-3 | 3.25 | 1.14 |
| 2010-06-22 | Brett Cecil | L | 24 | W 4-9 | vs SLN | 12 | 29 | L | 5.0 | 8 | 6 | 6 | 2 | 1 | 4 | 89 | 31 | 58 | 65% | 7-4 | 4.08 | 1.09 |
| 2010-06-23 | Ricky Romero | L | 26 | W 0-1 | vs SLN | 15 | 44 | - | 8.0 | 8 | 0 | 0 | 0 | 1 | 5 | 106 | 45 | 61 | 58% | 6-3 | 2.86 | 1.22 |
| 2010-06-24 | Brandon Morrow | R | 26 | L 5-0 | vs SLN | 15 | 30 | W | 8.0 | 5 | 0 | 0 | 0 | 1 | 8 | 112 | 41 | 71 | 63% | 5-5 | 4.50 | 1.39 |
| 2010-06-25 | Jesse Litsch | R | 25 | W 0-9 | vs PHI | 3 | 53 | L | 4.0 | 7 | 6 | 6 | 0 | 4 | 0 | 85 | 40 | 45 | 53% | 0-2 | 9.00 | 1.85 |
| 2010-06-26 | Shaun Marcum | R | 29 | L 5-1 | vs PHI | 16 | 80 | W | 6.0 | 5 | 1 | 1 | 1 | 1 | 6 | 99 | 34 | 65 | 66% | 7-3 | 3.15 | 1.14 |
| 2010-06-27 | Brett Cecil | L | 24 | W 2-11 | vs PHI | 13 | 30 | L | 4.2 | 10 | 7 | 5 | 0 | 1 | 5 | 97 | 30 | 67 | 69% | 7-5 | 4.39 | 1.16 |
| 2010-06-28 | Ricky Romero | L | 26 | L 1-2 | @ CLE | 16 | 45 | L | 7.0 | 7 | 2 | 2 | 0 | 3 | 2 | 108 | 39 | 69 | 64% | 6-4 | 2.84 | 1.23 |
| 2010-06-29 | Brandon Morrow | R | 26 | L 4-5 | @ CLE | 16 | 31 | L | 6.0 | 7 | 5 | 3 | 1 | 2 | 8 | 95 | 33 | 62 | 65% | 5-6 | 4.50 | 1.40 |
| 2010-06-30 | Jesse Litsch | R | 25 | L 1-3 | @ CLE | 4 | 54 | L | 6.0 | 4 | 2 | 2 | 1 | 2 | 2 | 99 | 43 | 56 | 57% | 0-3 | 7.11 | 1.58 |
| 2010-07-01 | Shaun Marcum | R | 29 | L 1-6 | @ CLE | 17 | 81 | L | 4.0 | 5 | 6 | 5 | 2 | 3 | 7 | 85 | 31 | 54 | 64% | 7-4 | 3.45 | 1.17 |
| 2010-07-02 | Brett Cecil | L | 24 | W 6-1 | @ NYA | 14 | 31 | - | 6.0 | 4 | 1 | 1 | 0 | 6 | 5 | 99 | 45 | 54 | 55% | 7-5 | 4.19 | 1.20 |
| 2010-07-03 | Ricky Romero | L | 26 | L 3-11 | @ NYA | 17 | 46 | L | 2.2 | 7 | 8 | 8 | 1 | 2 | 3 | 77 | 32 | 45 | 58% | 6-5 | 3.39 | 1.28 |
| 2010-07-04 | Brandon Morrow | R | 26 | L 6-7 | @ NYA | 17 | 32 | - | 6.0 | 9 | 5 | 5 | 1 | 1 | 7 | 118 | 45 | 73 | 62% | 5-6 | 4.69 | 1.42 |
| 2010-07-06 | Jesse Litsch | R | 25 | W 6-7 | vs MIN | 5 | 55 | - | 5.1 | 7 | 5 | 5 | 2 | 2 | 0 | 76 | 30 | 46 | 61% | 0-3 | 7.20 | 1.56 |
| 2010-07-07 | Marc Rzepczynski | L | 25 | L 6-5 | vs MIN | 1 | 12 | - | 5.2 | 8 | 4 | 4 | 2 | 1 | 7 | 96 | 36 | 60 | 63% | 0-0 | 6.00 | 1.50 |
| 2010-07-08 | Brett Cecil | L | 24 | L 8-1 | vs MIN | 15 | 32 | W | 7.0 | 4 | 1 | 1 | 1 | 1 | 2 | 89 | 33 | 56 | 63% | 8-5 | 3.97 | 1.16 |
| 2010-07-09 | Ricky Romero | L | 26 | W 3-14 | vs BOS | 18 | 47 | L | 2.1 | 5 | 9 | 5 | 1 | 3 | 2 | 56 | 26 | 30 | 54% | 6-6 | 3.72 | 1.33 |
| 2010-07-10 | Brandon Morrow | R | 26 | L 9-5 | vs BOS | 18 | 33 | - | 4.0 | 8 | 5 | 4 | 0 | 2 | 4 | 102 | 36 | 66 | 65% | 5-6 | 4.86 | 1.46 |
| 2010-07-11 | Jesse Litsch | R | 25 | W 2-3 | vs BOS | 6 | 56 | L | 7.0 | 4 | 3 | 3 | 2 | 1 | 5 | 99 | 38 | 61 | 62% | 0-4 | 6.47 | 1.38 |
| 2010-07-16 | Ricky Romero | L | 26 | W 4-2 | @ BAL | 19 | 48 | W | 7.0 | 5 | 2 | 0 | 0 | 1 | 5 | 94 | 30 | 64 | 68% | 7-6 | 3.51 | 1.30 |
| 2010-07-17 | Brandon Morrow | R | 26 | W 3-2 | @ BAL | 19 | 34 | W | 7.0 | 5 | 2 | 2 | 0 | 2 | 8 | 93 | 32 | 61 | 66% | 6-6 | 4.71 | 1.43 |
| 2010-07-18 | Shaun Marcum | R | 29 | W 10-1 | @ BAL | 18 | 82 | W | 5.0 | 9 | 1 | 1 | 0 | 0 | 4 | 82 | 23 | 59 | 72% | 8-4 | 3.38 | 1.20 |
| 2010-07-19 | Brett Cecil | L | 24 | L 4-5 | @ KCA | 16 | 33 | - | 6.1 | 6 | 3 | 3 | 0 | 3 | 1 | 94 | 33 | 61 | 65% | 8-5 | 4.00 | 1.18 |
| 2010-07-20 | Jesse Litsch | R | 25 | W 13-1 | @ KCA | 7 | 57 | W | 5.2 | 8 | 1 | 1 | 0 | 0 | 0 | 84 | 33 | 51 | 61% | 1-4 | 5.84 | 1.41 |
| 2010-07-21 | Marc Rzepczynski | L | 25 | L 2-5 | @ KCA | 2 | 13 | L | 4.2 | 9 | 5 | 5 | 0 | 1 | 3 | 95 | 36 | 59 | 62% | 0-1 | 7.36 | 1.82 |
| 2010-07-22 | Ricky Romero | L | 26 | L 2-5 | @ DET | 20 | 49 | L | 7.0 | 7 | 3 | 3 | 0 | 4 | 3 | 103 | 46 | 57 | 55% | 7-7 | 3.53 | 1.32 |
| 2010-07-24 | Shaun Marcum | R | 29 | W 3-2 | @ DET | 19 | 83 | W | 5.2 | 8 | 2 | 2 | 0 | 1 | 5 | 97 | 33 | 64 | 66% | 9-4 | 3.36 | 1.21 |
| 2010-07-25 | Brett Cecil | L | 24 | W 5-3 | @ DET | 17 | 34 | - | 7.0 | 6 | 2 | 2 | 1 | 1 | 6 | 103 | 37 | 66 | 64% | 8-5 | 3.91 | 1.17 |
| 2010-07-25 | Jesse Litsch | R | 25 | L 5-6 | @ DET | 8 | 58 | - | 5.1 | 5 | 2 | 2 | 0 | 3 | 3 | 82 | 31 | 51 | 62% | 1-4 | 5.44 | 1.40 |
| 2010-07-26 | Brandon Morrow | R | 26 | L 9-5 | vs BAL | 20 | 35 | W | 6.0 | 5 | 2 | 2 | 1 | 4 | 6 | 99 | 41 | 58 | 59% | 7-6 | 4.62 | 1.43 |
| 2010-07-27 | Ricky Romero | L | 26 | L 8-2 | vs BAL | 21 | 50 | W | 7.2 | 9 | 2 | 2 | 0 | 1 | 8 | 101 | 37 | 64 | 63% | 8-7 | 3.46 | 1.31 |
| 2010-07-28 | Brad Mills | L | 25 | L 5-0 | vs BAL | 1 | 3 | W | 7.0 | 2 | 0 | 0 | 0 | 3 | 4 | 91 | 34 | 57 | 63% | 1-0 | 0.00 | 0.71 |
| 2010-07-30 | Shaun Marcum | R | 29 | L 8-1 | vs CLE | 20 | 84 | W | 7.0 | 3 | 1 | 1 | 0 | 0 | 10 | 104 | 37 | 67 | 64% | 10-4 | 3.24 | 1.17 |
| 2010-07-31 | Brett Cecil | L | 24 | W 1-2 | vs CLE | 18 | 35 | - | 6.0 | 5 | 1 | 1 | 0 | 5 | 5 | 114 | 47 | 67 | 59% | 8-5 | 3.78 | 1.20 |
| 2010-08-01 | Jesse Litsch | R | 25 | W 4-5 | vs CLE | 9 | 59 | L | 4.0 | 6 | 4 | 4 | 1 | 2 | 1 | 74 | 33 | 41 | 55% | 1-5 | 5.74 | 1.45 |
| 2010-08-02 | Brandon Morrow | R | 26 | W 8-6 | @ NYA | 21 | 36 | W | 5.1 | 7 | 5 | 5 | 2 | 2 | 9 | 105 | 43 | 62 | 59% | 8-6 | 4.81 | 1.45 |
| 2010-08-03 | Ricky Romero | L | 26 | W 8-2 | @ NYA | 22 | 51 | W | 9.0 | 2 | 2 | 2 | 1 | 1 | 4 | 117 | 42 | 75 | 64% | 9-7 | 3.37 | 1.25 |
| 2010-08-04 | Shaun Marcum | R | 29 | L 1-5 | @ NYA | 21 | 85 | L | 6.0 | 8 | 5 | 5 | 1 | 1 | 5 | 101 | 40 | 61 | 60% | 10-5 | 3.44 | 1.18 |
| 2010-08-06 | Brett Cecil | L | 24 | L 2-1 | vs TBA | 19 | 36 | W | 7.0 | 4 | 1 | 1 | 0 | 2 | 9 | 112 | 39 | 73 | 65% | 9-5 | 3.63 | 1.18 |
| 2010-08-07 | Brad Mills | L | 25 | L 17-11 | vs TBA | 2 | 4 | - | 4.0 | 5 | 5 | 5 | 0 | 4 | 2 | 96 | 42 | 54 | 56% | 1-0 | 4.09 | 1.27 |
| 2010-08-08 | Brandon Morrow | R | 26 | L 1-0 | vs TBA | 22 | 37 | W | 9.0 | 1 | 0 | 0 | 0 | 2 | 17 | 137 | 40 | 97 | 71% | 9-6 | 4.46 | 1.37 |
| 2010-08-10 | Ricky Romero | L | 26 | W 5-7 | vs BOS | 23 | 52 | - | 6.0 | 8 | 5 | 5 | 1 | 2 | 4 | 108 | 48 | 60 | 56% | 9-7 | 3.53 | 1.27 |
| 2010-08-11 | Shaun Marcum | R | 29 | W 1-10 | vs BOS | 22 | 86 | L | 4.0 | 7 | 8 | 8 | 4 | 3 | 3 | 92 | 40 | 52 | 57% | 10-6 | 3.87 | 1.22 |
| 2010-08-12 | Brad Mills | L | 25 | L 6-5 | vs BOS | 3 | 5 | - | 4.1 | 7 | 4 | 4 | 2 | 2 | 7 | 98 | 38 | 60 | 61% | 1-0 | 5.40 | 1.53 |
| 2010-08-13 | Marc Rzepczynski | L | 25 | W 3-0 | @ ANA | 3 | 14 | W | 7.0 | 2 | 0 | 0 | 0 | 0 | 6 | 107 | 40 | 67 | 63% | 1-1 | 4.50 | 1.22 |
| 2010-08-14 | Brett Cecil | L | 24 | L 2-7 | @ ANA | 20 | 37 | L | 5.2 | 10 | 7 | 7 | 3 | 1 | 1 | 72 | 23 | 49 | 68% | 9-6 | 3.96 | 1.21 |
| 2010-08-15 | Ricky Romero | L | 26 | W 4-1 | @ ANA | 24 | 53 | W | 7.0 | 6 | 1 | 1 | 1 | 3 | 4 | 99 | 38 | 61 | 62% | 10-7 | 3.43 | 1.27 |
| 2010-08-16 | Shaun Marcum | R | 29 | W 3-1 | @ OAK | 23 | 87 | W | 9.0 | 1 | 1 | 1 | 1 | 1 | 5 | 103 | 30 | 73 | 71% | 11-6 | 3.69 | 1.16 |
| 2010-08-17 | Brandon Morrow | R | 26 | L 2-6 | @ OAK | 23 | 38 | - | 4.0 | 4 | 2 | 2 | 0 | 3 | 2 | 90 | 39 | 51 | 57% | 9-6 | 4.47 | 1.38 |
| 2010-08-18 | Marc Rzepczynski | L | 25 | L 4-5 | @ OAK | 4 | 15 | - | 4.1 | 5 | 3 | 3 | 0 | 5 | 0 | 78 | 37 | 41 | 53% | 1-1 | 4.70 | 1.39 |
| 2010-08-20 | Brett Cecil | L | 24 | W 16-2 | @ BOS | 21 | 38 | W | 6.2 | 9 | 2 | 2 | 0 | 3 | 6 | 115 | 44 | 71 | 62% | 10-6 | 3.89 | 1.23 |
| 2010-08-21 | Ricky Romero | L | 26 | L 4-5 | @ BOS | 25 | 54 | - | 7.0 | 9 | 4 | 4 | 0 | 1 | 8 | 116 | 45 | 71 | 61% | 10-7 | 3.50 | 1.28 |
| 2010-08-22 | Shaun Marcum | R | 29 | L 0-5 | @ BOS | 24 | 88 | L | 7.0 | 4 | 3 | 3 | 1 | 0 | 6 | 91 | 32 | 59 | 65% | 11-7 | 3.70 | 1.13 |
| 2010-08-23 | Brandon Morrow | R | 26 | L 3-2 | vs NYA | 24 | 39 | - | 6.0 | 4 | 2 | 2 | 0 | 2 | 12 | 103 | 38 | 65 | 63% | 9-6 | 4.40 | 1.36 |
| 2010-08-24 | Marc Rzepczynski | L | 25 | W 5-11 | vs NYA | 5 | 16 | L | 3.0 | 8 | 6 | 6 | 3 | 2 | 1 | 68 | 27 | 41 | 60% | 1-2 | 6.23 | 1.62 |
| 2010-08-25 | Brett Cecil | L | 24 | L 6-3 | vs NYA | 22 | 39 | W | 8.0 | 7 | 2 | 2 | 1 | 2 | 5 | 106 | 37 | 69 | 65% | 11-6 | 3.79 | 1.23 |
| 2010-08-26 | Ricky Romero | L | 26 | W 1-7 | vs DET | 26 | 55 | L | 5.2 | 4 | 6 | 3 | 2 | 5 | 4 | 98 | 51 | 47 | 48% | 10-8 | 3.54 | 1.28 |
| 2010-08-27 | Shaun Marcum | R | 29 | L 3-2 | vs DET | 25 | 89 | - | 6.0 | 8 | 1 | 1 | 1 | 2 | 4 | 100 | 37 | 63 | 63% | 11-7 | 3.61 | 1.15 |
| 2010-08-28 | Brandon Morrow | R | 26 | L 5-4 | vs DET | 25 | 40 | W | 6.0 | 5 | 1 | 1 | 1 | 1 | 9 | 98 | 37 | 61 | 62% | 10-6 | 4.28 | 1.35 |
| 2010-08-29 | Marc Rzepczynski | L | 25 | W 4-10 | vs DET | 6 | 17 | L | 5.2 | 5 | 4 | 3 | 0 | 5 | 8 | 97 | 41 | 56 | 58% | 1-3 | 6.10 | 1.68 |
| 2010-08-30 | Brett Cecil | L | 24 | L 2-6 | @ TBA | 23 | 40 | L | 7.0 | 5 | 5 | 2 | 1 | 1 | 5 | 108 | 36 | 72 | 67% | 11-7 | 3.73 | 1.21 |
| 2010-08-31 | Ricky Romero | L | 26 | W 13-5 | @ TBA | 27 | 56 | W | 7.1 | 3 | 5 | 4 | 0 | 5 | 5 | 103 | 41 | 62 | 60% | 11-8 | 3.60 | 1.28 |
| 2010-09-01 | Shaun Marcum | R | 29 | L 1-2 | @ TBA | 26 | 90 | - | 6.0 | 5 | 1 | 1 | 1 | 2 | 7 | 103 | 36 | 67 | 65% | 11-7 | 3.53 | 1.15 |
| 2010-09-03 | Brandon Morrow | R | 26 | L 3-7 | @ NYA | 26 | 41 | L | 3.0 | 6 | 5 | 5 | 0 | 3 | 4 | 71 | 32 | 39 | 55% | 10-7 | 4.50 | 1.38 |
| 2010-09-04 | Marc Rzepczynski | L | 25 | L 5-7 | @ NYA | 7 | 18 | - | 4.0 | 6 | 5 | 5 | 0 | 3 | 1 | 77 | 33 | 44 | 57% | 1-3 | 6.69 | 1.74 |
| 2010-09-05 | Brett Cecil | L | 24 | W 7-3 | @ NYA | 24 | 41 | W | 6.1 | 7 | 3 | 3 | 0 | 4 | 3 | 109 | 48 | 61 | 56% | 12-7 | 3.76 | 1.24 |
| 2010-09-06 | Ricky Romero | L | 26 | L 7-2 | vs TEX | 28 | 57 | W | 7.0 | 7 | 1 | 1 | 0 | 2 | 2 | 98 | 36 | 62 | 63% | 12-8 | 3.51 | 1.28 |
| 2010-09-07 | Shaun Marcum | R | 29 | L 8-5 | vs TEX | 27 | 91 | W | 7.0 | 6 | 3 | 3 | 1 | 2 | 8 | 94 | 30 | 64 | 68% | 12-7 | 3.55 | 1.15 |
| 2010-09-08 | Marc Rzepczynski | L | 25 | W 1-8 | vs TEX | 8 | 19 | L | 5.0 | 7 | 3 | 3 | 1 | 3 | 2 | 79 | 36 | 43 | 54% | 1-4 | 6.53 | 1.78 |
| 2010-09-09 | Shawn Hill | R | 29 | W 2-4 | vs TEX | 1 | 41 | L | 5.1 | 8 | 4 | 3 | 0 | 1 | 2 | 85 | 32 | 53 | 62% | 0-1 | 5.40 | 1.80 |
| 2010-09-10 | Brett Cecil | L | 24 | W 8-9 | vs TBA | 25 | 42 | - | 2.0 | 8 | 7 | 7 | 1 | 2 | 3 | 52 | 20 | 32 | 62% | 12-7 | 4.12 | 1.28 |
| 2010-09-11 | Ricky Romero | L | 26 | W 1-13 | vs TBA | 29 | 58 | L | 4.0 | 3 | 6 | 6 | 1 | 3 | 7 | 85 | 41 | 44 | 52% | 12-9 | 3.72 | 1.28 |
| 2010-09-12 | Shaun Marcum | R | 29 | L 5-4 | vs TBA | 28 | 92 | - | 6.0 | 6 | 3 | 3 | 0 | 2 | 6 | 105 | 41 | 64 | 61% | 12-7 | 3.58 | 1.16 |
| 2010-09-13 | Marc Rzepczynski | L | 25 | L 3-4 | @ BAL | 9 | 20 | - | 5.0 | 6 | 2 | 2 | 1 | 2 | 3 | 92 | 37 | 55 | 60% | 1-4 | 6.20 | 1.76 |
| 2010-09-14 | Shawn Hill | R | 29 | L 3-11 | @ BAL | 2 | 42 | L | 5.2 | 9 | 3 | 2 | 1 | 1 | 4 | 97 | 30 | 67 | 69% | 0-2 | 4.09 | 1.73 |
| 2010-09-15 | Kyle Drabek | R | 23 | L 1-3 | @ BAL | 1 | 1 | L | 6.0 | 9 | 3 | 3 | 0 | 3 | 5 | 92 | 37 | 55 | 60% | 0-1 | 4.50 | 2.00 |
| 2010-09-17 | Brett Cecil | L | 24 | W 11-9 | @ BOS | 26 | 43 | W | 6.0 | 7 | 5 | 5 | 1 | 2 | 0 | 96 | 40 | 56 | 58% | 13-7 | 4.25 | 1.29 |
| 2010-09-18 | Ricky Romero | L | 26 | W 4-3 | @ BOS | 30 | 59 | W | 6.0 | 7 | 3 | 3 | 0 | 3 | 4 | 113 | 41 | 72 | 64% | 13-9 | 3.75 | 1.29 |
| 2010-09-19 | Shaun Marcum | R | 29 | L 0-6 | @ BOS | 29 | 93 | L | 5.1 | 9 | 6 | 6 | 2 | 0 | 3 | 90 | 31 | 59 | 66% | 12-8 | 3.78 | 1.18 |
| 2010-09-21 | Marc Rzepczynski | L | 25 | L 5-3 | vs SEA | 10 | 21 | W | 6.1 | 7 | 2 | 2 | 0 | 3 | 8 | 95 | 26 | 69 | 73% | 2-4 | 5.71 | 1.71 |
| 2010-09-22 | Kyle Drabek | R | 23 | W 3-6 | vs SEA | 2 | 2 | L | 5.0 | 4 | 3 | 3 | 2 | 1 | 3 | 84 | 34 | 50 | 60% | 0-2 | 4.91 | 1.55 |
| 2010-09-23 | Shawn Hill | R | 29 | L 1-0 | vs SEA | 3 | 43 | W | 5.0 | 4 | 0 | 0 | 0 | 1 | 7 | 85 | 35 | 50 | 59% | 1-2 | 2.81 | 1.50 |
| 2010-09-24 | Brett Cecil | L | 24 | L 6-4 | vs BAL | 27 | 44 | W | 6.1 | 11 | 3 | 2 | 0 | 0 | 4 | 90 | 23 | 67 | 74% | 14-7 | 4.20 | 1.31 |
| 2010-09-25 | Ricky Romero | L | 26 | L 5-4 | vs BAL | 31 | 60 | - | 5.0 | 5 | 3 | 3 | 0 | 5 | 3 | 104 | 41 | 63 | 61% | 13-9 | 3.79 | 1.31 |
| 2010-09-26 | Shaun Marcum | R | 29 | L 5-2 | vs BAL | 30 | 94 | W | 7.0 | 4 | 1 | 0 | 0 | 2 | 7 | 102 | 34 | 68 | 67% | 13-8 | 3.64 | 1.16 |
| 2010-09-27 | Marc Rzepczynski | L | 25 | L 7-5 | vs NYA | 11 | 22 | W | 5.0 | 4 | 2 | 2 | 1 | 3 | 9 | 91 | 34 | 57 | 63% | 3-4 | 5.53 | 1.68 |
| 2010-09-28 | Kyle Drabek | R | 23 | W 1-6 | vs NYA | 3 | 3 | L | 6.0 | 5 | 3 | 3 | 0 | 1 | 4 | 88 | 37 | 51 | 58% | 0-3 | 4.76 | 1.35 |
| 2010-09-29 | Brett Cecil | L | 24 | L 8-4 | vs NYA | 28 | 45 | W | 5.1 | 9 | 3 | 3 | 1 | 1 | 2 | 92 | 30 | 62 | 67% | 15-7 | 4.21 | 1.32 |
| 2010-09-30 | Shawn Hill | R | 29 | W 13-2 | @ MIN | 4 | 44 | - | 4.2 | 3 | 1 | 1 | 0 | 1 | 1 | 93 | 42 | 51 | 55% | 1-2 | 2.57 | 1.33 |
| 2010-10-01 | Ricky Romero | L | 26 | W 6-3 | @ MIN | 32 | 61 | W | 8.0 | 6 | 2 | 2 | 1 | 0 | 5 | 113 | 38 | 75 | 66% | 14-9 | 3.73 | 1.29 |
| 2010-10-02 | Shaun Marcum | R | 29 | L 4-5 | @ MIN | 31 | 95 | - | 7.0 | 5 | 3 | 3 | 0 | 0 | 4 | 90 | 27 | 63 | 70% | 13-8 | 3.65 | 1.15 |
| 2010-10-03 | Marc Rzepczynski | L | 25 | W 2-1 | @ MIN | 12 | 23 | W | 7.0 | 4 | 1 | 0 | 0 | 2 | 6 | 105 | 34 | 71 | 68% | 4-4 | 4.92 | 1.59 |