| 2010-04-05 | vs CHN | 1 | W 16-5 | 0-1 | 3 | 53,081 | Derek Lowe | Carlos Zambrano | Derek Lowe | Carlos Zambrano | | 16 | 5 | 11 |
| 2010-04-07 | vs CHN | 2 | W 3-2 | 1-1 | 2 | 36,170 | Jair Jurrjens | Ryan Dempster | Peter Moylan | John Grabow | Billy Wagner | 19 | 7 | 12 |
| 2010-04-08 | vs CHN | 3 | L 0-2 | 1-2 | 3 | 27,443 | Tommy Hanson | Randy Wells | Randy Wells | Tommy Hanson | Carlos Marmol | 19 | 9 | 10 |
| 2010-04-09 | @ SFN | 4 | L 4-5 | 1-3 | 4 | 42,940 | Tim Hudson | Jonathan Sanchez | Jeremy Affeldt | Kris Medlen | | 23 | 14 | 9 |
| 2010-04-10 | @ SFN | 5 | W 7-2 | 2-3 | 3 | 42,985 | Derek Lowe | Todd Wellemeyer | Derek Lowe | Todd Wellemeyer | | 30 | 16 | 14 |
| 2010-04-11 | @ SFN | 6 | L 3-6 | 2-4 | 4 | 38,062 | Kenshin Kawakami | Tim Lincecum | Tim Lincecum | Kenshin Kawakami | Jeremy Affeldt | 33 | 22 | 11 |
| 2010-04-12 | @ SDN | 7 | L 2-17 | 3-4 | 3 | 42,843 | Jair Jurrjens | Kevin Correia | Kevin Correia | Jair Jurrjens | | 35 | 39 | -4 |
| 2010-04-14 | @ SDN | 8 | W 6-1 | 4-4 | 3 | 24,969 | Tommy Hanson | Clayton Richard | Tommy Hanson | Clayton Richard | | 41 | 40 | 1 |
| 2010-04-15 | @ SDN | 9 | W 6-2 | 5-4 | 3 | 16,356 | Tim Hudson | Mat Latos | Tim Hudson | Mat Latos | | 47 | 42 | 5 |
| 2010-04-16 | vs COL | 10 | W 9-5 | 6-4 | 2 | 27,692 | Derek Lowe | Jason Hammel | Derek Lowe | Jason Hammel | | 56 | 47 | 9 |
| 2010-04-17 | vs COL | 11 | L 0-4 | 6-5 | 4 | 32,602 | Kenshin Kawakami | Ubaldo Jimenez | Ubaldo Jimenez | Kenshin Kawakami | | 56 | 51 | 5 |
| 2010-04-18 | vs COL | 12 | W 4-3 | 7-5 | 3 | 26,546 | Jair Jurrjens | Greg Smith | Eric O'Flaherty | Franklin Morales | | 60 | 54 | 6 |
| 2010-04-20 | vs PHI | 13 | W 4-3 | 8-5 | 2 | 18,032 | Tommy Hanson | Kyle Kendrick | Billy Wagner | Jose Contreras | | 64 | 57 | 7 |
| 2010-04-21 | vs PHI | 14 | L 0-2 | 8-6 | 2 | 21,171 | Tim Hudson | Roy Halladay | Roy Halladay | Tim Hudson | | 64 | 59 | 5 |
| 2010-04-22 | vs PHI | 15 | L 3-8 | 8-7 | 4 | 22,476 | Derek Lowe | Jamie Moyer | Jamie Moyer | Derek Lowe | | 67 | 67 | 0 |
| 2010-04-23 | @ NYN | 16 | L 2-5 | 8-8 | 5 | 32,265 | Kenshin Kawakami | John Maine | Hisanori Takahashi | Kenshin Kawakami | Francisco Rodriguez | 69 | 72 | -3 |
| 2010-04-24 | @ NYN | 17 | L 1-3 | 8-9 | 6 | 36,547 | Jair Jurrjens | Jonathon Niese | Manny Acosta | Jair Jurrjens | Francisco Rodriguez | 70 | 75 | -5 |
| 2010-04-25 | @ NYN | 18 | L 0-1 | 8-10 | 5 | 27,623 | Tommy Hanson | Mike Pelfrey | Mike Pelfrey | Tommy Hanson | | 70 | 76 | -6 |
| 2010-04-26 | @ SLN | 19 | L 3-4 | 8-11 | 5 | 35,257 | Tim Hudson | Kyle Lohse | Dennys Reyes | Takashi Saito | Ryan Franklin | 73 | 80 | -7 |
| 2010-04-27 | @ SLN | 20 | L 4-5 | 8-12 | 6 | 35,587 | Derek Lowe | Chris Carpenter | Chris Carpenter | Derek Lowe | Jason Motte | 77 | 85 | -8 |
| 2010-04-28 | @ SLN | 21 | L 0-6 | 8-13 | 5 | 35,693 | Kenshin Kawakami | Jaime Garcia | Jaime Garcia | Kenshin Kawakami | | 77 | 91 | -14 |
| 2010-04-29 | @ SLN | 22 | L 4-10 | 9-13 | 5 | 39,561 | Jair Jurrjens | Adam Wainwright | Adam Wainwright | Jair Jurrjens | | 81 | 101 | -20 |
| 2010-04-30 | vs HOU | 23 | W 4-2 | 10-13 | 5 | 30,082 | Tommy Hanson | Brett Myers | Tommy Hanson | Brett Myers | Billy Wagner | 85 | 103 | -18 |
| 2010-05-01 | vs HOU | 24 | W 10-1 | 11-13 | 5 | 27,035 | Tim Hudson | Wandy Rodriguez | Tim Hudson | Wandy Rodriguez | | 95 | 104 | -9 |
| 2010-05-02 | vs HOU | 25 | W 7-1 | 12-13 | 5 | 25,665 | Derek Lowe | Bud Norris | Derek Lowe | Bud Norris | | 102 | 105 | -3 |
| 2010-05-04 | @ WAS | 26 | L 3-6 | 12-14 | 5 | 17,098 | Kenshin Kawakami | Livan Hernandez | Livan Hernandez | Kenshin Kawakami | Matt Capps | 105 | 111 | -6 |
| 2010-05-05 | @ WAS | 27 | W 7-6 | 13-14 | 4 | 15,616 | Tommy Hanson | Luis Atilano | Kris Medlen | Matt Capps | Billy Wagner | 112 | 117 | -5 |
| 2010-05-06 | @ WAS | 28 | L 2-3 | 13-15 | 4 | 17,131 | Tim Hudson | Scott Olsen | Tyler Clippard | Eric O'Flaherty | | 114 | 120 | -6 |
| 2010-05-07 | @ PHI | 29 | L 0-7 | 13-16 | 5 | 45,349 | Derek Lowe | Jamie Moyer | Jamie Moyer | Derek Lowe | | 114 | 127 | -13 |
| 2010-05-08 | @ PHI | 30 | W 4-1 | 14-16 | 4 | 45,395 | Kris Medlen | Joe Blanton | Eric O'Flaherty | Joe Blanton | Billy Wagner | 118 | 128 | -10 |
| 2010-05-09 | @ PHI | 31 | L 3-5 | 14-17 | 4 | 45,193 | Kenshin Kawakami | Cole Hamels | Cole Hamels | Kenshin Kawakami | Brad Lidge | 121 | 133 | -12 |
| 2010-05-10 | @ MIL | 32 | W 8-2 | 15-17 | 4 | 24,365 | Tommy Hanson | Doug Davis | Tommy Hanson | Doug Davis | | 129 | 135 | -6 |
| 2010-05-11 | @ MIL | 33 | W 11-3 | 15-18 | 5 | 30,678 | Tim Hudson | David Bush | Tim Hudson | David Bush | | 140 | 138 | 2 |
| 2010-05-12 | @ MIL | 34 | W 9-2 | 16-18 | 4 | 30,175 | Derek Lowe | Yovani Gallardo | Derek Lowe | Manny Parra | | 149 | 140 | 9 |
| 2010-05-14 | vs ARI | 35 | W 6-5 | 17-18 | 5 | 30,657 | Kenshin Kawakami | Ian Kennedy | Billy Wagner | Chad Qualls | | 155 | 145 | 10 |
| 2010-05-15 | vs ARI | 36 | L 1-11 | 17-19 | 6 | 32,718 | Tommy Hanson | Rodrigo Lopez | Rodrigo Lopez | Tommy Hanson | | 156 | 156 | 0 |
| 2010-05-16 | vs ARI | 37 | W 13-1 | 18-19 | 5 | 31,758 | Tim Hudson | Dan Haren | Tim Hudson | Dan Haren | | 169 | 157 | 12 |
| 2010-05-17 | vs NYN | 38 | L 2-3 | 18-20 | 5 | 21,086 | Derek Lowe | Mike Pelfrey | Mike Pelfrey | Derek Lowe | Francisco Rodriguez | 171 | 160 | 11 |
| 2010-05-18 | vs NYN | 39 | W 3-2 | 19-20 | 5 | 27,119 | Kris Medlen | Johan Santana | Billy Wagner | Pedro Feliciano | | 174 | 162 | 12 |
| 2010-05-19 | vs CIN | 40 | W 5-4 | 20-20 | 5 | 25,347 | Kenshin Kawakami | Aaron Harang | Billy Wagner | Nick Masset | | 179 | 166 | 13 |
| 2010-05-20 | vs CIN | 41 | W 10-9 | 20-21 | 5 | 21,621 | Tommy Hanson | Mike Leake | Craig Kimbrel | Francisco Cordero | | 189 | 175 | 14 |
| 2010-05-21 | @ PIT | 42 | W 7-0 | 21-21 | 3 | 22,470 | Tim Hudson | Ross Ohlendorf | Tim Hudson | Ross Ohlendorf | | 196 | 175 | 21 |
| 2010-05-22 | @ PIT | 43 | W 4-2 | 22-21 | 3 | 26,519 | Derek Lowe | Charlie Morton | Derek Lowe | Charlie Morton | Billy Wagner | 200 | 177 | 23 |
| 2010-05-23 | @ PIT | 44 | L 2-3 | 22-22 | 4 | 23,045 | Kris Medlen | Zach Duke | Octavio Dotel | Takashi Saito | | 202 | 180 | 22 |
| 2010-05-25 | @ FLO | 45 | L 4-6 | 22-23 | 5 | 11,434 | Kenshin Kawakami | Anibal Sanchez | Anibal Sanchez | Kenshin Kawakami | | 206 | 186 | 20 |
| 2010-05-26 | @ FLO | 46 | W 7-3 | 23-23 | 3 | 15,238 | Tommy Hanson | Nate Robertson | Tommy Hanson | Burke Badenhop | | 213 | 189 | 24 |
| 2010-05-27 | @ FLO | 47 | W 8-3 | 24-23 | 3 | 11,381 | Tim Hudson | Ricky Nolasco | Peter Moylan | Ricky Nolasco | | 221 | 192 | 29 |
| 2010-05-28 | vs PIT | 48 | W 7-3 | 25-23 | 3 | 23,442 | Derek Lowe | Zach Duke | Derek Lowe | Zach Duke | | 228 | 195 | 33 |
| 2010-05-29 | vs PIT | 49 | W 6-3 | 26-23 | 2 | 29,134 | Kris Medlen | Brian Burres | Kris Medlen | Brian Burres | Billy Wagner | 234 | 198 | 36 |
| 2010-05-30 | vs PIT | 50 | W 5-2 | 27-23 | 2 | 31,078 | Kenshin Kawakami | Paul Maholm | Takashi Saito | Joel Hanrahan | Billy Wagner | 239 | 200 | 39 |
| 2010-05-31 | vs PHI | 51 | W 9-3 | 28-23 | 1 | 42,543 | Tommy Hanson | Joe Blanton | Tommy Hanson | Joe Blanton | | 248 | 203 | 45 |
| 2010-06-01 | vs PHI | 52 | W 7-3 | 29-23 | 1 | 29,731 | Tim Hudson | Cole Hamels | Tim Hudson | Cole Hamels | Billy Wagner | 255 | 206 | 49 |
| 2010-06-02 | vs PHI | 53 | W 2-1 | 30-23 | 1 | 26,309 | Derek Lowe | Kyle Kendrick | Derek Lowe | Jose Contreras | Billy Wagner | 257 | 207 | 50 |
| 2010-06-03 | @ LAN | 54 | W 4-3 | 31-23 | 1 | 35,333 | Kris Medlen | Hiroki Kuroda | Kris Medlen | Hiroki Kuroda | Jonny Venters | 261 | 210 | 51 |
| 2010-06-04 | @ LAN | 55 | L 4-5 | 31-24 | 1 | 42,459 | Kenshin Kawakami | Clayton Kershaw | Hong-Chih Kuo | Kenshin Kawakami | Jonathan Broxton | 265 | 215 | 50 |
| 2010-06-05 | @ LAN | 56 | W 9-3 | 32-24 | 1 | 48,207 | Tommy Hanson | Chad Billingsley | Tommy Hanson | Chad Billingsley | | 274 | 218 | 56 |
| 2010-06-06 | @ LAN | 57 | L 4-5 | 32-25 | 1 | 37,944 | Tim Hudson | John Ely | Ronald Belisario | Jesse Chavez | | 278 | 223 | 55 |
| 2010-06-07 | @ ARI | 58 | L 4-7 | 32-26 | 1 | 17,731 | Derek Lowe | Dan Haren | Dan Haren | Derek Lowe | Chad Qualls | 282 | 230 | 52 |
| 2010-06-08 | @ ARI | 59 | W 7-5 | 33-26 | 1 | 17,052 | Kris Medlen | Edwin Jackson | Jonny Venters | Esmerling Vasquez | Billy Wagner | 289 | 235 | 54 |
| 2010-06-09 | @ ARI | 60 | L 1-2 | 33-27 | 2 | 19,138 | Kenshin Kawakami | Ian Kennedy | Aaron Heilman | Peter Moylan | Chad Qualls | 290 | 237 | 53 |
| 2010-06-10 | @ ARI | 61 | W 11-7 | 33-28 | 3 | 26,969 | Tommy Hanson | Dontrelle Willis | Peter Moylan | Chad Qualls | | 301 | 244 | 57 |
| 2010-06-11 | @ MIN | 62 | L 1-2 | 33-29 | 2 | 39,428 | Tim Hudson | Francisco Liriano | Francisco Liriano | Tim Hudson | Jon Rauch | 302 | 246 | 56 |
| 2010-06-12 | @ MIN | 63 | W 3-2 | 34-29 | 2 | 40,001 | Derek Lowe | Nick Blackburn | Jonny Venters | Matt Guerrier | Billy Wagner | 305 | 248 | 57 |
| 2010-06-13 | @ MIN | 64 | W 7-3 | 35-29 | 2 | 39,772 | Kris Medlen | Kevin Slowey | Kris Medlen | Kevin Slowey | | 312 | 251 | 61 |
| 2010-06-15 | vs TBA | 65 | L 4-10 | 36-29 | 2 | 30,448 | Kenshin Kawakami | David Price | David Price | Kenshin Kawakami | | 316 | 261 | 55 |
| 2010-06-16 | vs TBA | 66 | W 6-2 | 37-29 | 2 | 26,807 | Tommy Hanson | Wade Davis | Tommy Hanson | Wade Davis | | 322 | 263 | 59 |
| 2010-06-17 | vs TBA | 67 | W 3-1 | 38-29 | 2 | 30,427 | Tim Hudson | James Shields | Tim Hudson | James Shields | Billy Wagner | 325 | 264 | 61 |
| 2010-06-18 | vs KCA | 68 | W 6-4 | 39-29 | 2 | 29,808 | Derek Lowe | Brian Bannister | Derek Lowe | Brian Bannister | Billy Wagner | 331 | 268 | 63 |
| 2010-06-19 | vs KCA | 69 | W 5-4 | 40-29 | 1 | 39,109 | Kris Medlen | Zack Greinke | Billy Wagner | Rob Tejeda | | 336 | 272 | 64 |
| 2010-06-20 | vs KCA | 70 | W 8-5 | 41-29 | 1 | 30,072 | Kenshin Kawakami | Kyle Davies | Craig Kimbrel | Blake Wood | Billy Wagner | 344 | 277 | 67 |
| 2010-06-22 | @ CHA | 71 | L 6-9 | 41-30 | 1 | 28,773 | Tommy Hanson | John Danks | John Danks | Tommy Hanson | Bobby Jenks | 350 | 286 | 64 |
| 2010-06-23 | @ CHA | 72 | L 2-4 | 41-31 | 1 | 27,561 | Tim Hudson | Mark Buehrle | Mark Buehrle | Tim Hudson | Bobby Jenks | 352 | 290 | 62 |
| 2010-06-24 | @ CHA | 73 | L 0-2 | 41-32 | 1 | 31,076 | Derek Lowe | Gavin Floyd | J.J. Putz | Takashi Saito | Bobby Jenks | 352 | 292 | 60 |
| 2010-06-25 | vs DET | 74 | W 3-1 | 42-32 | 1 | 36,634 | Kris Medlen | Andrew Oliver | Kris Medlen | Andrew Oliver | Billy Wagner | 355 | 293 | 62 |
| 2010-06-26 | vs DET | 75 | W 4-3 | 43-32 | 1 | 39,184 | Kenshin Kawakami | Max Scherzer | Kenshin Kawakami | Joel Zumaya | Peter Moylan | 359 | 296 | 63 |
| 2010-06-27 | vs DET | 76 | L 4-10 | 44-32 | 1 | 26,034 | Tommy Hanson | Justin Verlander | Justin Verlander | Tommy Hanson | | 363 | 306 | 57 |
| 2010-06-28 | vs WAS | 77 | W 5-0 | 45-32 | 1 | 42,889 | Tim Hudson | Stephen Strasburg | Tim Hudson | Stephen Strasburg | | 368 | 306 | 62 |
| 2010-06-29 | vs WAS | 78 | L 2-7 | 45-33 | 1 | 19,045 | Derek Lowe | Craig Stammen | Craig Stammen | Derek Lowe | | 370 | 313 | 57 |
| 2010-06-30 | vs WAS | 79 | W 4-1 | 46-33 | 1 | 20,091 | Jair Jurrjens | J.D. Martin | Jair Jurrjens | J.D. Martin | Billy Wagner | 374 | 314 | 60 |
| 2010-07-02 | vs FLO | 80 | W 4-3 | 47-33 | 1 | 34,332 | Kris Medlen | Josh Johnson | Jonny Venters | Leo Nunez | | 378 | 317 | 61 |
| 2010-07-03 | vs FLO | 81 | W 4-1 | 48-33 | 1 | 30,148 | Tommy Hanson | Anibal Sanchez | Tommy Hanson | Anibal Sanchez | Billy Wagner | 382 | 318 | 64 |
| 2010-07-04 | vs FLO | 82 | L 2-3 | 48-34 | 1 | 44,163 | Tim Hudson | Ricky Nolasco | Ricky Nolasco | Tim Hudson | Leo Nunez | 384 | 321 | 63 |
| 2010-07-05 | @ PHI | 83 | L 1-3 | 48-35 | 1 | 45,404 | Derek Lowe | Roy Halladay | Roy Halladay | Derek Lowe | | 385 | 324 | 61 |
| 2010-07-06 | @ PHI | 84 | W 6-3 | 49-35 | 1 | 44,715 | Jair Jurrjens | Cole Hamels | Jesse Chavez | David Herndon | Billy Wagner | 391 | 327 | 64 |
| 2010-07-07 | @ PHI | 85 | W 7-5 | 50-35 | 1 | 44,282 | Kris Medlen | Jamie Moyer | Kris Medlen | Jamie Moyer | Billy Wagner | 398 | 332 | 66 |
| 2010-07-09 | @ NYN | 86 | W 4-2 | 51-35 | 1 | 36,356 | Tommy Hanson | R.A. Dickey | Eric O'Flaherty | R.A. Dickey | Billy Wagner | 402 | 334 | 68 |
| 2010-07-10 | @ NYN | 87 | W 4-0 | 52-35 | 1 | 37,793 | Tim Hudson | Mike Pelfrey | Tim Hudson | Mike Pelfrey | | 406 | 334 | 72 |
| 2010-07-11 | @ NYN | 88 | L 0-3 | 52-36 | 1 | 36,402 | Derek Lowe | Johan Santana | Johan Santana | Derek Lowe | Francisco Rodriguez | 406 | 337 | 69 |
| 2010-07-15 | vs MIL | 89 | W 2-1 | 53-36 | 1 | 35,057 | Jair Jurrjens | David Bush | Jair Jurrjens | David Bush | Billy Wagner | 408 | 338 | 70 |
| 2010-07-16 | vs MIL | 90 | L 3-9 | 53-37 | 1 | 37,014 | Tommy Hanson | Randy Wolf | Randy Wolf | Tommy Hanson | | 411 | 347 | 64 |
| 2010-07-17 | vs MIL | 91 | L 3-6 | 53-38 | 1 | 48,174 | Tim Hudson | Chris Narveson | Chris Narveson | Tim Hudson | John Axford | 414 | 353 | 61 |
| 2010-07-18 | vs MIL | 92 | W 11-6 | 53-39 | 1 | 24,732 | Derek Lowe | Manny Parra | Derek Lowe | Manny Parra | | 425 | 359 | 66 |
| 2010-07-20 | vs SDN | 93 | W 4-1 | 54-39 | 1 | 30,621 | Jair Jurrjens | Wade LeBlanc | Jair Jurrjens | Wade LeBlanc | Billy Wagner | 429 | 360 | 69 |
| 2010-07-21 | vs SDN | 94 | L 4-6 | 54-40 | 1 | 30,039 | Tommy Hanson | Jon Garland | Tim Stauffer | Kris Medlen | Heath Bell | 433 | 366 | 67 |
| 2010-07-22 | vs SDN | 95 | W 8-0 | 55-40 | 1 | 26,450 | Tim Hudson | Clayton Richard | Tim Hudson | Clayton Richard | | 441 | 366 | 75 |
| 2010-07-23 | @ FLO | 96 | L 6-7 | 55-41 | 1 | 19,204 | Derek Lowe | Alejandro Sanabia | Jose Veras | Billy Wagner | | 447 | 373 | 74 |
| 2010-07-24 | @ FLO | 97 | W 10-5 | 55-42 | 1 | 30,245 | Kris Medlen | Anibal Sanchez | Jesse Chavez | Jhan Marinez | | 457 | 378 | 79 |
| 2010-07-25 | @ FLO | 98 | L 4-5 | 55-43 | 1 | 17,321 | Jair Jurrjens | Chris Volstad | Jorge Sosa | Jesse Chavez | | 461 | 383 | 78 |
| 2010-07-27 | @ WAS | 99 | L 0-3 | 55-44 | 1 | 40,043 | Tommy Hanson | Miguel Batista | Miguel Batista | Tommy Hanson | Matt Capps | 461 | 386 | 75 |
| 2010-07-28 | @ WAS | 100 | W 3-1 | 56-44 | 1 | 24,263 | Tim Hudson | Livan Hernandez | Tim Hudson | Livan Hernandez | Billy Wagner | 464 | 387 | 77 |
| 2010-07-29 | @ WAS | 101 | L 3-5 | 56-45 | 1 | 30,263 | Derek Lowe | Scott Olsen | Scott Olsen | Derek Lowe | Matt Capps | 467 | 392 | 75 |
| 2010-07-30 | @ CIN | 102 | W 6-4 | 57-45 | 1 | 40,373 | Kris Medlen | Johnny Cueto | Jesse Chavez | Francisco Cordero | Billy Wagner | 473 | 396 | 77 |
| 2010-07-31 | @ CIN | 103 | L 2-5 | 57-46 | 1 | 41,611 | Jair Jurrjens | Bronson Arroyo | Bronson Arroyo | Jair Jurrjens | Francisco Cordero | 475 | 401 | 74 |
| 2010-08-01 | @ CIN | 104 | L 1-2 | 57-47 | 1 | 40,871 | Tommy Hanson | Edinson Volquez | Edinson Volquez | Tommy Hanson | Francisco Cordero | 476 | 403 | 73 |
| 2010-08-02 | vs NYN | 105 | W 4-1 | 58-47 | 1 | 33,030 | Tim Hudson | Johan Santana | Tim Hudson | Johan Santana | Billy Wagner | 480 | 404 | 76 |
| 2010-08-03 | vs NYN | 106 | L 2-3 | 58-48 | 1 | 26,578 | Derek Lowe | R.A. Dickey | Manny Acosta | Billy Wagner | Francisco Rodriguez | 482 | 407 | 75 |
| 2010-08-04 | vs NYN | 107 | W 8-3 | 59-48 | 1 | 28,536 | Kris Medlen | Mike Pelfrey | Michael Dunn | Mike Pelfrey | | 490 | 410 | 80 |
| 2010-08-05 | vs SFN | 108 | W 3-2 | 60-48 | 1 | 24,538 | Jair Jurrjens | Tim Lincecum | Jair Jurrjens | Tim Lincecum | Billy Wagner | 493 | 412 | 81 |
| 2010-08-06 | vs SFN | 109 | L 2-3 | 60-49 | 1 | 42,178 | Tommy Hanson | Barry Zito | Javier Lopez | Peter Moylan | Brian Wilson | 495 | 415 | 80 |
| 2010-08-07 | vs SFN | 110 | W 3-0 | 61-49 | 1 | 47,305 | Tim Hudson | Matt Cain | Tim Hudson | Matt Cain | Billy Wagner | 498 | 415 | 83 |
| 2010-08-08 | vs SFN | 111 | W 6-3 | 62-49 | 1 | 33,865 | Derek Lowe | Jonathan Sanchez | Derek Lowe | Jonathan Sanchez | Takashi Saito | 504 | 418 | 86 |
| 2010-08-09 | @ HOU | 112 | L 4-10 | 63-49 | 1 | 34,684 | Mike Minor | Bud Norris | Tim Byrdak | Kyle Farnsworth | | 508 | 428 | 80 |
| 2010-08-10 | @ HOU | 113 | W 4-2 | 64-49 | 1 | 34,155 | Jair Jurrjens | J.A. Happ | Jonny Venters | Matt Lindstrom | Billy Wagner | 512 | 430 | 82 |
| 2010-08-11 | @ HOU | 114 | W 8-2 | 65-49 | 1 | 31,352 | Tommy Hanson | Wandy Rodriguez | Billy Wagner | Brandon Lyon | | 520 | 432 | 88 |
| 2010-08-13 | vs LAN | 115 | W 1-0 | 66-49 | 1 | 38,602 | Tim Hudson | Hiroki Kuroda | Tim Hudson | Hiroki Kuroda | Billy Wagner | 521 | 432 | 89 |
| 2010-08-14 | vs LAN | 116 | L 1-2 | 66-50 | 1 | 49,267 | Derek Lowe | Ted Lilly | Ted Lilly | Derek Lowe | Hong-Chih Kuo | 522 | 434 | 88 |
| 2010-08-15 | vs LAN | 117 | W 13-1 | 67-50 | 1 | 28,105 | Jair Jurrjens | Vicente Padilla | Jair Jurrjens | Vicente Padilla | | 535 | 435 | 100 |
| 2010-08-16 | vs LAN | 118 | W 4-3 | 68-50 | 1 | 20,414 | Tommy Hanson | Chad Billingsley | Peter Moylan | Hong-Chih Kuo | | 539 | 438 | 101 |
| 2010-08-17 | vs WAS | 119 | W 10-2 | 68-51 | 1 | 16,911 | Mike Minor | Scott Olsen | Mike Minor | Scott Olsen | | 549 | 440 | 109 |
| 2010-08-18 | vs WAS | 120 | W 3-2 | 69-51 | 1 | 18,105 | Tim Hudson | Livan Hernandez | Billy Wagner | Sean Burnett | | 552 | 442 | 110 |
| 2010-08-19 | vs WAS | 121 | L 2-6 | 69-52 | 1 | 15,593 | Derek Lowe | John Lannan | John Lannan | Derek Lowe | | 554 | 448 | 106 |
| 2010-08-20 | @ CHN | 122 | W 5-3 | 70-52 | 1 | 39,345 | Jair Jurrjens | Ryan Dempster | Peter Moylan | Carlos Marmol | Billy Wagner | 559 | 451 | 108 |
| 2010-08-21 | @ CHN | 123 | L 4-5 | 70-53 | 1 | 41,099 | Tommy Hanson | Tom Gorzelanny | Tom Gorzelanny | Tommy Hanson | Carlos Marmol | 563 | 456 | 107 |
| 2010-08-22 | @ CHN | 124 | W 16-5 | 70-54 | 1 | 37,518 | Mike Minor | Randy Wells | Mike Minor | Randy Wells | | 579 | 461 | 118 |
| 2010-08-23 | @ COL | 125 | L 4-5 | 70-55 | 1 | 34,172 | Tim Hudson | Jason Hammel | Rafael Betancourt | Jonny Venters | Huston Street | 583 | 466 | 117 |
| 2010-08-24 | @ COL | 126 | L 2-5 | 70-56 | 1 | 34,485 | Derek Lowe | Jorge de la Rosa | Jorge de la Rosa | Derek Lowe | Huston Street | 585 | 471 | 114 |
| 2010-08-25 | @ COL | 127 | L 10-12 | 70-57 | 1 | 27,675 | Jair Jurrjens | Esmil Rogers | Matt Belisle | Jonny Venters | | 595 | 483 | 112 |
| 2010-08-27 | vs FLO | 128 | L 1-7 | 70-58 | 1 | 29,722 | Tommy Hanson | Chris Volstad | Chris Volstad | Tommy Hanson | | 596 | 490 | 106 |
| 2010-08-28 | vs FLO | 129 | W 12-3 | 70-59 | 1 | 43,846 | Tim Hudson | Ricky Nolasco | Tim Hudson | Ricky Nolasco | | 608 | 493 | 115 |
| 2010-08-29 | vs FLO | 130 | W 7-6 | 71-59 | 1 | 38,170 | Derek Lowe | Josh Johnson | Takashi Saito | Leo Nunez | | 615 | 499 | 116 |
| 2010-08-30 | vs NYN | 131 | W 9-3 | 72-59 | 1 | 18,842 | Jair Jurrjens | Pat Misch | Jair Jurrjens | Pat Misch | | 624 | 502 | 122 |
| 2010-08-31 | vs NYN | 132 | W 9-2 | 73-59 | 1 | 18,430 | Mike Minor | Jonathon Niese | Mike Minor | Jonathon Niese | | 633 | 504 | 129 |
| 2010-09-01 | vs NYN | 133 | W 4-1 | 74-59 | 1 | 19,938 | Tommy Hanson | Mike Pelfrey | Tommy Hanson | Mike Pelfrey | Billy Wagner | 637 | 505 | 132 |
| 2010-09-02 | vs NYN | 134 | L 2-4 | 74-60 | 1 | 24,895 | Tim Hudson | Johan Santana | Johan Santana | Tim Hudson | Hisanori Takahashi | 639 | 509 | 130 |
| 2010-09-03 | @ FLO | 135 | L 1-6 | 74-61 | 1 | 19,226 | Kenshin Kawakami | Andrew Miller | Andrew Miller | Kenshin Kawakami | | 640 | 515 | 125 |
| 2010-09-04 | @ FLO | 136 | W 2-0 | 75-61 | 1 | 23,912 | Jair Jurrjens | Josh Johnson | Jair Jurrjens | Josh Johnson | Billy Wagner | 642 | 515 | 127 |
| 2010-09-05 | @ FLO | 137 | L 6-7 | 75-62 | 1 | 19,504 | Mike Minor | Alejandro Sanabia | Burke Badenhop | Eric O'Flaherty | | 648 | 522 | 126 |
| 2010-09-06 | @ PIT | 138 | L 1-3 | 75-63 | 1 | 15,330 | Tommy Hanson | Brian Burres | Brian Burres | Tommy Hanson | Joel Hanrahan | 649 | 525 | 124 |
| 2010-09-07 | @ PIT | 139 | L 0-5 | 75-64 | 1 | 11,070 | Tim Hudson | James McDonald | James McDonald | Tim Hudson | | 649 | 530 | 119 |
| 2010-09-08 | @ PIT | 140 | W 9-3 | 76-64 | 1 | 13,113 | Derek Lowe | Zach Duke | Derek Lowe | Zach Duke | | 658 | 533 | 125 |
| 2010-09-09 | vs SLN | 141 | L 4-11 | 77-64 | 1 | 20,776 | Jair Jurrjens | Adam Wainwright | Adam Wainwright | Jair Jurrjens | | 662 | 544 | 118 |
| 2010-09-10 | vs SLN | 142 | W 8-6 | 78-64 | 1 | 40,656 | Mike Minor | Chris Carpenter | Peter Moylan | Chris Carpenter | Billy Wagner | 670 | 550 | 120 |
| 2010-09-11 | vs SLN | 143 | W 6-3 | 79-64 | 1 | 51,078 | Tommy Hanson | Jake Westbrook | Craig Kimbrel | Mitchell Boggs | | 676 | 553 | 123 |
| 2010-09-12 | vs SLN | 144 | L 3-7 | 79-65 | 1 | 27,156 | Tim Hudson | Kyle Lohse | Kyle Lohse | Tim Hudson | | 679 | 560 | 119 |
| 2010-09-13 | vs WAS | 145 | W 4-0 | 80-65 | 1 | 18,647 | Derek Lowe | Yuniesky Maya | Derek Lowe | Yuniesky Maya | | 683 | 560 | 123 |
| 2010-09-14 | vs WAS | 146 | L 0-6 | 80-66 | 1 | 26,954 | Jair Jurrjens | Livan Hernandez | Livan Hernandez | Jair Jurrjens | | 683 | 566 | 117 |
| 2010-09-15 | vs WAS | 147 | L 2-4 | 80-67 | 1 | 19,237 | Mike Minor | John Lannan | John Lannan | Mike Minor | Drew Storen | 685 | 570 | 115 |
| 2010-09-17 | @ NYN | 148 | W 6-4 | 81-67 | 1 | 28,002 | Tommy Hanson | Jonathon Niese | Tommy Hanson | Jonathon Niese | Billy Wagner | 691 | 574 | 117 |
| 2010-09-18 | @ NYN | 149 | W 4-2 | 82-67 | 1 | 33,051 | Tim Hudson | Dillon Gee | Tim Hudson | Dillon Gee | Billy Wagner | 695 | 576 | 119 |
| 2010-09-19 | @ NYN | 150 | W 6-3 | 83-67 | 1 | 33,612 | Derek Lowe | R.A. Dickey | Derek Lowe | R.A. Dickey | Craig Kimbrel | 701 | 579 | 122 |
| 2010-09-20 | @ PHI | 151 | L 1-3 | 83-68 | 1 | 45,256 | Brandon Beachy | Cole Hamels | Cole Hamels | Brandon Beachy | Brad Lidge | 702 | 582 | 120 |
| 2010-09-21 | @ PHI | 152 | L 3-5 | 83-69 | 1 | 45,264 | Mike Minor | Roy Halladay | Roy Halladay | Mike Minor | Brad Lidge | 705 | 587 | 118 |
| 2010-09-22 | @ PHI | 153 | L 0-1 | 83-70 | 2 | 45,310 | Tommy Hanson | Roy Oswalt | Ryan Madson | Jonny Venters | Brad Lidge | 705 | 588 | 117 |
| 2010-09-24 | @ WAS | 154 | L 3-8 | 83-71 | 2 | 22,515 | Tim Hudson | Jordan Zimmermann | Jordan Zimmermann | Tim Hudson | | 708 | 596 | 112 |
| 2010-09-25 | @ WAS | 155 | W 5-0 | 84-71 | 2 | 23,824 | Derek Lowe | Yuniesky Maya | Derek Lowe | Yuniesky Maya | | 713 | 596 | 117 |
| 2010-09-26 | @ WAS | 156 | L 2-4 | 84-72 | 2 | 21,625 | Brandon Beachy | Livan Hernandez | Sean Burnett | Kyle Farnsworth | Drew Storen | 715 | 600 | 115 |
| 2010-09-27 | vs FLO | 157 | W 2-1 | 85-72 | 2 | 26,338 | Tommy Hanson | Alejandro Sanabia | Michael Dunn | Jose Veras | | 717 | 601 | 116 |
| 2010-09-28 | vs FLO | 158 | W 3-2 | 86-72 | 1 | 36,155 | Tim Hudson | Anibal Sanchez | Craig Kimbrel | Anibal Sanchez | Billy Wagner | 720 | 603 | 117 |
| 2010-09-29 | vs FLO | 159 | W 5-1 | 87-72 | 1 | 36,390 | Derek Lowe | Andrew Miller | Derek Lowe | Andrew Miller | | 725 | 604 | 121 |
| 2010-10-01 | vs PHI | 160 | L 5-11 | 88-72 | 1 | 51,139 | Brandon Beachy | Kyle Kendrick | Kyle Kendrick | Brandon Beachy | | 730 | 615 | 115 |
| 2010-10-02 | vs PHI | 161 | L 0-7 | 88-73 | 1 | 54,296 | Tommy Hanson | Vance Worley | Antonio Bastardo | Jonny Venters | | 730 | 622 | 108 |
| 2010-10-03 | vs PHI | 162 | W 8-7 | 89-73 | 1 | 52,613 | Tim Hudson | Cole Hamels | Tim Hudson | Danys Baez | Billy Wagner | 738 | 629 | 109 |