| 2010-04-05 | @ ARI | 1 | L 3-6 | 0-1 | 5 | 49,192 | Jon Garland | Dan Haren | Dan Haren | Jon Garland | | 3 | 6 | -3 |
| 2010-04-06 | @ ARI | 2 | W 6-3 | 1-1 | 5 | 19,177 | Chris Young | Edwin Jackson | Chris Young | Edwin Jackson | Heath Bell | 9 | 9 | 0 |
| 2010-04-07 | @ ARI | 3 | L 3-5 | 1-2 | 5 | 17,673 | Kevin Correia | Ian Kennedy | Blaine Boyer | Kevin Correia | Chad Qualls | 12 | 14 | -2 |
| 2010-04-09 | @ COL | 4 | L 0-7 | 1-3 | 5 | 49,509 | Clayton Richard | Jorge de la Rosa | Jorge de la Rosa | Clayton Richard | | 12 | 21 | -9 |
| 2010-04-10 | @ COL | 5 | W 5-4 | 2-3 | 5 | 36,090 | Mat Latos | Jason Hammel | Tim Stauffer | Manuel Corpas | Heath Bell | 17 | 25 | -8 |
| 2010-04-11 | @ COL | 6 | L 2-4 | 2-4 | 5 | 39,576 | Jon Garland | Ubaldo Jimenez | Ubaldo Jimenez | Jon Garland | Franklin Morales | 19 | 29 | -10 |
| 2010-04-12 | vs ATL | 7 | W 17-2 | 2-5 | 5 | 42,843 | Kevin Correia | Jair Jurrjens | Kevin Correia | Jair Jurrjens | | 36 | 31 | 5 |
| 2010-04-14 | vs ATL | 8 | L 1-6 | 2-6 | 5 | 24,969 | Clayton Richard | Tommy Hanson | Tommy Hanson | Clayton Richard | | 37 | 37 | 0 |
| 2010-04-15 | vs ATL | 9 | L 2-6 | 2-7 | 5 | 16,356 | Mat Latos | Tim Hudson | Tim Hudson | Mat Latos | | 39 | 43 | -4 |
| 2010-04-16 | vs ARI | 10 | W 6-3 | 3-7 | 5 | 26,632 | Jon Garland | Edwin Jackson | Heath Bell | Juan Gutierrez | | 45 | 46 | -1 |
| 2010-04-17 | vs ARI | 11 | W 5-0 | 4-7 | 5 | 31,324 | Kevin Correia | Kris Benson | Kevin Correia | Kris Benson | | 50 | 46 | 4 |
| 2010-04-18 | vs ARI | 12 | W 5-3 | 5-7 | 4 | 20,634 | Wade LeBlanc | Ian Kennedy | Edward Mujica | Aaron Heilman | Heath Bell | 55 | 49 | 6 |
| 2010-04-19 | vs SFN | 13 | W 3-2 | 6-7 | 2 | 17,087 | Clayton Richard | Matt Cain | Tim Stauffer | Jeremy Affeldt | | 58 | 51 | 7 |
| 2010-04-20 | vs SFN | 14 | W 1-0 | 7-7 | 2 | 17,822 | Mat Latos | Jonathan Sanchez | Mat Latos | Jonathan Sanchez | Heath Bell | 59 | 51 | 8 |
| 2010-04-21 | vs SFN | 15 | W 5-2 | 8-7 | 1 | 14,906 | Jon Garland | Todd Wellemeyer | Jon Garland | Todd Wellemeyer | | 64 | 53 | 11 |
| 2010-04-23 | @ CIN | 16 | W 10-4 | 8-8 | 2 | 15,183 | Kevin Correia | Bronson Arroyo | Kevin Correia | Bronson Arroyo | | 74 | 57 | 17 |
| 2010-04-24 | @ CIN | 17 | W 5-0 | 9-8 | 2 | 19,999 | Wade LeBlanc | Johnny Cueto | Wade LeBlanc | Johnny Cueto | | 79 | 57 | 22 |
| 2010-04-25 | @ CIN | 18 | L 4-5 | 9-9 | 2 | 17,694 | Clayton Richard | Homer Bailey | Arthur Rhodes | Mike Adams | Francisco Cordero | 83 | 62 | 21 |
| 2010-04-26 | @ FLO | 19 | L 1-10 | 9-10 | 2 | 10,924 | Mat Latos | Josh Johnson | Josh Johnson | Mat Latos | | 84 | 72 | 12 |
| 2010-04-27 | @ FLO | 20 | W 4-1 | 10-10 | 2 | 11,613 | Jon Garland | Anibal Sanchez | Jon Garland | Anibal Sanchez | Heath Bell | 88 | 73 | 15 |
| 2010-04-28 | @ FLO | 21 | W 6-4 | 11-10 | 2 | 16,310 | Kevin Correia | Nate Robertson | Kevin Correia | Nate Robertson | Heath Bell | 94 | 77 | 17 |
| 2010-04-29 | vs MIL | 22 | W 9-0 | 12-10 | 2 | 16,696 | Wade LeBlanc | Doug Davis | Wade LeBlanc | Doug Davis | | 103 | 77 | 26 |
| 2010-04-30 | vs MIL | 23 | W 3-0 | 13-10 | 2 | 29,366 | Clayton Richard | David Bush | Clayton Richard | David Bush | Heath Bell | 106 | 77 | 29 |
| 2010-05-01 | vs MIL | 24 | L 1-2 | 13-11 | 2 | 25,619 | Mat Latos | Yovani Gallardo | Yovani Gallardo | Mat Latos | Trevor Hoffman | 107 | 79 | 28 |
| 2010-05-02 | vs MIL | 25 | W 8-0 | 14-11 | 2 | 20,074 | Jon Garland | Randy Wolf | Jon Garland | Randy Wolf | | 115 | 79 | 36 |
| 2010-05-03 | vs COL | 26 | L 2-5 | 14-12 | 2 | 15,052 | Kevin Correia | Ubaldo Jimenez | Ubaldo Jimenez | Kevin Correia | | 117 | 84 | 33 |
| 2010-05-04 | vs COL | 27 | W 3-2 | 15-12 | 2 | 16,329 | Wade LeBlanc | Greg Smith | Heath Bell | Franklin Morales | | 120 | 86 | 34 |
| 2010-05-05 | vs COL | 28 | L 5-6 | 15-13 | 2 | 17,121 | Clayton Richard | Aaron Cook | Manuel Corpas | Tim Stauffer | | 125 | 92 | 33 |
| 2010-05-07 | @ HOU | 29 | W 7-0 | 16-13 | 2 | 25,586 | Mat Latos | Bud Norris | Mat Latos | Bud Norris | | 132 | 92 | 40 |
| 2010-05-08 | @ HOU | 30 | W 2-1 | 17-13 | 2 | 27,038 | Jon Garland | Felipe Paulino | Jon Garland | Felipe Paulino | Heath Bell | 134 | 93 | 41 |
| 2010-05-09 | @ HOU | 31 | L 3-4 | 17-14 | 2 | 23,526 | Tim Stauffer | Roy Oswalt | Brandon Lyon | Ryan Webb | | 137 | 97 | 40 |
| 2010-05-11 | @ SFN | 32 | W 3-2 | 18-14 | 2 | 33,249 | Wade LeBlanc | Barry Zito | Ryan Webb | Barry Zito | Heath Bell | 140 | 99 | 41 |
| 2010-05-12 | @ SFN | 33 | W 5-2 | 19-14 | 1 | 30,924 | Clayton Richard | Matt Cain | Clayton Richard | Matt Cain | Heath Bell | 145 | 101 | 44 |
| 2010-05-13 | @ SFN | 34 | W 1-0 | 20-14 | 1 | 32,861 | Mat Latos | Jonathan Sanchez | Mat Latos | Jonathan Sanchez | | 146 | 101 | 45 |
| 2010-05-14 | vs LAN | 35 | L 3-4 | 20-15 | 1 | 42,056 | Jon Garland | Ramon Ortiz | Jeff Weaver | Luke Gregerson | Jonathan Broxton | 149 | 105 | 44 |
| 2010-05-15 | vs LAN | 36 | L 1-4 | 20-16 | 3 | 42,436 | Kevin Correia | Clayton Kershaw | Clayton Kershaw | Kevin Correia | Jonathan Broxton | 150 | 109 | 41 |
| 2010-05-16 | vs LAN | 37 | L 0-1 | 20-17 | 3 | 42,327 | Wade LeBlanc | Chad Billingsley | Chad Billingsley | Wade LeBlanc | Jonathan Broxton | 150 | 110 | 40 |
| 2010-05-17 | vs SFN | 38 | W 3-1 | 21-17 | 3 | 20,558 | Clayton Richard | Matt Cain | Clayton Richard | Matt Cain | Heath Bell | 153 | 111 | 42 |
| 2010-05-18 | vs SFN | 39 | L 6-7 | 21-18 | 3 | 19,565 | Mat Latos | Jonathan Sanchez | Dan Runzler | Cesar Ramos | Brian Wilson | 159 | 118 | 41 |
| 2010-05-19 | @ LAN | 40 | W 10-5 | 21-19 | 3 | 40,138 | Jon Garland | Ramon Ortiz | Jon Garland | Ramon Ortiz | | 169 | 123 | 46 |
| 2010-05-20 | @ LAN | 41 | L 1-4 | 21-20 | 3 | 38,856 | Kevin Correia | Clayton Kershaw | Clayton Kershaw | Kevin Correia | Jonathan Broxton | 170 | 127 | 43 |
| 2010-05-21 | @ SEA | 42 | L 8-15 | 22-20 | 3 | 24,139 | Wade LeBlanc | Cliff Lee | Cliff Lee | Wade LeBlanc | | 178 | 142 | 36 |
| 2010-05-22 | @ SEA | 43 | W 2-1 | 23-20 | 2 | 28,670 | Clayton Richard | Ian Snell | Clayton Richard | Ian Snell | Heath Bell | 180 | 143 | 37 |
| 2010-05-23 | @ SEA | 44 | W 8-1 | 24-20 | 2 | 33,315 | Mat Latos | Felix Hernandez | Mat Latos | Felix Hernandez | | 188 | 144 | 44 |
| 2010-05-25 | vs SLN | 45 | W 1-0 | 25-20 | 2 | 18,236 | Jon Garland | Adam Wainwright | Jon Garland | Adam Wainwright | Heath Bell | 189 | 144 | 45 |
| 2010-05-26 | vs SLN | 46 | W 2-1 | 26-20 | 2 | 19,752 | Kevin Correia | Jaime Garcia | Edward Mujica | Mitchell Boggs | | 191 | 145 | 46 |
| 2010-05-27 | vs SLN | 47 | L 3-8 | 26-21 | 2 | 20,583 | Wade LeBlanc | P.J. Walters | P.J. Walters | Wade LeBlanc | | 194 | 153 | 41 |
| 2010-05-28 | vs WAS | 48 | L 3-5 | 26-22 | 2 | 23,468 | Clayton Richard | John Lannan | John Lannan | Clayton Richard | Matt Capps | 197 | 158 | 39 |
| 2010-05-29 | vs WAS | 49 | W 4-2 | 27-22 | 2 | 25,956 | Mat Latos | J.D. Martin | Mat Latos | J.D. Martin | Heath Bell | 201 | 160 | 41 |
| 2010-05-30 | vs WAS | 50 | W 3-2 | 28-22 | 2 | 28,591 | Jon Garland | Livan Hernandez | Luke Gregerson | Sean Burnett | | 204 | 162 | 42 |
| 2010-05-31 | vs NYN | 51 | W 18-6 | 28-23 | 2 | 20,023 | Kevin Correia | Hisanori Takahashi | Kevin Correia | Hisanori Takahashi | | 222 | 168 | 54 |
| 2010-06-01 | vs NYN | 52 | L 2-4 | 28-24 | 2 | 17,393 | Wade LeBlanc | Mike Pelfrey | Mike Pelfrey | Wade LeBlanc | Francisco Rodriguez | 224 | 172 | 52 |
| 2010-06-02 | vs NYN | 53 | W 5-1 | 29-24 | 2 | 15,880 | Clayton Richard | Johan Santana | Ryan Webb | Raul Valdes | | 229 | 173 | 56 |
| 2010-06-04 | @ PHI | 54 | L 2-3 | 29-25 | 3 | 45,080 | Mat Latos | Roy Halladay | Roy Halladay | Mat Latos | Brad Lidge | 231 | 176 | 55 |
| 2010-06-05 | @ PHI | 55 | L 2-6 | 29-26 | 3 | 45,353 | Jon Garland | Jamie Moyer | Jamie Moyer | Jon Garland | | 233 | 182 | 51 |
| 2010-06-06 | @ PHI | 56 | W 6-5 | 30-26 | 3 | 44,852 | Kevin Correia | Joe Blanton | Mike Adams | Danys Baez | Heath Bell | 239 | 187 | 52 |
| 2010-06-07 | @ PHI | 57 | W 3-1 | 31-26 | 3 | 45,398 | Wade LeBlanc | Cole Hamels | Wade LeBlanc | Cole Hamels | Heath Bell | 242 | 188 | 54 |
| 2010-06-08 | @ NYN | 58 | L 1-2 | 31-27 | 3 | 30,086 | Clayton Richard | Mike Pelfrey | Elmer Dessens | Edward Mujica | | 243 | 190 | 53 |
| 2010-06-10 | @ NYN | 59 | W 4-2 | 32-28 | 4 | 32,365 | Mat Latos | Johan Santana | Mat Latos | Johan Santana | Heath Bell | 247 | 192 | 55 |
| 2010-06-10 | @ NYN | 60 | L 0-3 | 32-28 | 4 | 28,072 | Jon Garland | Jonathon Niese | Jonathon Niese | Jon Garland | | 247 | 195 | 52 |
| 2010-06-11 | vs SEA | 61 | W 4-3 | 33-28 | 3 | 20,049 | Kevin Correia | Jason Vargas | Joe Thatcher | David Aardsma | | 251 | 198 | 53 |
| 2010-06-12 | vs SEA | 62 | W 7-1 | 34-28 | 3 | 30,019 | Wade LeBlanc | Cliff Lee | Wade LeBlanc | Cliff Lee | | 258 | 199 | 59 |
| 2010-06-13 | vs SEA | 63 | L 2-4 | 34-29 | 3 | 23,429 | Clayton Richard | Felix Hernandez | Felix Hernandez | Luke Gregerson | David Aardsma | 260 | 203 | 57 |
| 2010-06-14 | vs TOR | 64 | L 3-6 | 34-30 | 3 | 16,542 | Jon Garland | Shaun Marcum | Shaun Marcum | Jon Garland | Kevin Gregg | 263 | 209 | 54 |
| 2010-06-15 | vs TOR | 65 | W 8-2 | 35-30 | 3 | 15,266 | Mat Latos | Brett Cecil | Mat Latos | Brett Cecil | | 271 | 211 | 60 |
| 2010-06-16 | vs TOR | 66 | L 1-7 | 35-31 | 3 | 16,050 | Kevin Correia | Ricky Romero | Ricky Romero | Kevin Correia | | 272 | 218 | 54 |
| 2010-06-18 | vs BAL | 67 | W 3-2 | 36-31 | 3 | 25,167 | Wade LeBlanc | Brian Matusz | Heath Bell | David Hernandez | | 275 | 220 | 55 |
| 2010-06-19 | vs BAL | 68 | L 4-5 | 36-32 | 3 | 28,138 | Clayton Richard | Kevin Millwood | Kevin Millwood | Clayton Richard | Alfredo Simon | 279 | 225 | 54 |
| 2010-06-20 | vs BAL | 69 | W 9-4 | 37-32 | 3 | 28,029 | Jon Garland | Jake Arrieta | Jon Garland | Jake Arrieta | | 288 | 229 | 59 |
| 2010-06-22 | @ TBA | 70 | W 2-1 | 38-32 | 3 | 14,650 | Mat Latos | Wade Davis | Mat Latos | Wade Davis | Heath Bell | 290 | 230 | 60 |
| 2010-06-23 | @ TBA | 71 | W 5-4 | 39-32 | 2 | 15,809 | Kevin Correia | James Shields | Luke Gregerson | James Shields | Heath Bell | 295 | 234 | 61 |
| 2010-06-24 | @ TBA | 72 | L 3-5 | 39-33 | 2 | 21,877 | Wade LeBlanc | Matt Garza | Matt Garza | Wade LeBlanc | Rafael Soriano | 298 | 239 | 59 |
| 2010-06-25 | @ FLO | 73 | W 3-0 | 40-33 | 2 | 16,718 | Clayton Richard | Chris Volstad | Clayton Richard | Chris Volstad | Heath Bell | 301 | 239 | 62 |
| 2010-06-26 | @ FLO | 74 | W 2-1 | 41-33 | 2 | 22,495 | Jon Garland | Josh Johnson | Jon Garland | Josh Johnson | Heath Bell | 303 | 240 | 63 |
| 2010-06-27 | @ FLO | 75 | W 4-2 | 42-33 | 2 | 16,044 | Mat Latos | Anibal Sanchez | Ryan Webb | Brian Sanches | Luke Gregerson | 307 | 242 | 65 |
| 2010-06-28 | vs COL | 76 | L 6-10 | 43-33 | 2 | 21,018 | Kevin Correia | Ubaldo Jimenez | Ubaldo Jimenez | Kevin Correia | | 313 | 252 | 61 |
| 2010-06-29 | vs COL | 77 | L 3-6 | 43-34 | 2 | 21,196 | Wade LeBlanc | Jason Hammel | Jason Hammel | Wade LeBlanc | Huston Street | 316 | 258 | 58 |
| 2010-06-30 | vs COL | 78 | W 13-3 | 43-35 | 2 | 24,519 | Clayton Richard | Jeff Francis | Clayton Richard | Jeff Francis | | 329 | 261 | 68 |
| 2010-07-01 | vs HOU | 79 | L 3-6 | 43-36 | 2 | 18,618 | Jon Garland | Brian Moehler | Chris Sampson | Luke Gregerson | Matt Lindstrom | 332 | 267 | 65 |
| 2010-07-02 | vs HOU | 80 | W 3-0 | 44-36 | 2 | 30,691 | Mat Latos | Roy Oswalt | Mat Latos | Brandon Lyon | Heath Bell | 335 | 267 | 68 |
| 2010-07-03 | vs HOU | 81 | W 1-0 | 45-36 | 2 | 40,042 | Kevin Correia | Bud Norris | Mike Adams | Gustavo Chacin | Heath Bell | 336 | 267 | 69 |
| 2010-07-04 | vs HOU | 82 | W 3-2 | 46-36 | 2 | 23,498 | Wade LeBlanc | Brett Myers | Heath Bell | Brandon Lyon | | 339 | 269 | 70 |
| 2010-07-06 | @ WAS | 83 | L 5-6 | 46-37 | 2 | 14,039 | Clayton Richard | Livan Hernandez | Matt Capps | Luke Gregerson | | 344 | 275 | 69 |
| 2010-07-07 | @ WAS | 84 | L 6-7 | 46-38 | 2 | 13,762 | Jon Garland | J.D. Martin | J.D. Martin | Jon Garland | Matt Capps | 350 | 282 | 68 |
| 2010-07-08 | @ WAS | 85 | W 7-1 | 47-38 | 2 | 17,364 | Mat Latos | Luis Atilano | Mat Latos | Luis Atilano | | 357 | 283 | 74 |
| 2010-07-09 | @ COL | 86 | L 8-10 | 48-38 | 2 | 36,123 | Kevin Correia | Jorge de la Rosa | Matt Belisle | Luke Gregerson | Huston Street | 365 | 293 | 72 |
| 2010-07-10 | @ COL | 87 | L 2-4 | 48-39 | 2 | 45,069 | Wade LeBlanc | Jason Hammel | Jason Hammel | Wade LeBlanc | Huston Street | 367 | 297 | 70 |
| 2010-07-11 | @ COL | 88 | W 9-7 | 49-39 | 2 | 40,460 | Clayton Richard | Jeff Francis | Luke Gregerson | Matt Belisle | Heath Bell | 376 | 304 | 72 |
| 2010-07-16 | vs ARI | 89 | W 12-1 | 50-39 | 2 | 33,177 | Jon Garland | Dan Haren | Jon Garland | Dan Haren | | 388 | 305 | 83 |
| 2010-07-17 | vs ARI | 90 | W 8-5 | 51-39 | 2 | 40,011 | Clayton Richard | Rodrigo Lopez | Clayton Richard | Rodrigo Lopez | Heath Bell | 396 | 310 | 86 |
| 2010-07-18 | vs ARI | 91 | W 6-4 | 52-39 | 1 | 25,363 | Kevin Correia | Edwin Jackson | Kevin Correia | Edwin Jackson | Heath Bell | 402 | 314 | 88 |
| 2010-07-20 | @ ATL | 92 | L 1-4 | 52-40 | 1 | 30,621 | Wade LeBlanc | Jair Jurrjens | Jair Jurrjens | Wade LeBlanc | Billy Wagner | 403 | 318 | 85 |
| 2010-07-21 | @ ATL | 93 | W 6-4 | 53-40 | 1 | 30,039 | Jon Garland | Tommy Hanson | Tim Stauffer | Kris Medlen | Heath Bell | 409 | 322 | 87 |
| 2010-07-22 | @ ATL | 94 | L 0-8 | 53-41 | 1 | 26,450 | Clayton Richard | Tim Hudson | Tim Hudson | Clayton Richard | | 409 | 330 | 79 |
| 2010-07-23 | @ PIT | 95 | W 5-3 | 54-41 | 1 | 18,611 | Kevin Correia | Paul Maholm | Kevin Correia | Paul Maholm | Heath Bell | 414 | 333 | 81 |
| 2010-07-24 | @ PIT | 96 | W 9-2 | 55-41 | 1 | 36,967 | Mat Latos | Jeff Karstens | Mat Latos | Jeff Karstens | | 423 | 335 | 88 |
| 2010-07-25 | @ PIT | 97 | W 6-3 | 56-41 | 1 | 18,800 | Wade LeBlanc | Brad Lincoln | Wade LeBlanc | Brad Lincoln | Heath Bell | 429 | 338 | 91 |
| 2010-07-27 | vs LAN | 98 | L 0-2 | 56-42 | 1 | 38,428 | Jon Garland | Chad Billingsley | Chad Billingsley | Jon Garland | Jonathan Broxton | 429 | 340 | 89 |
| 2010-07-28 | vs LAN | 99 | W 6-1 | 57-42 | 1 | 40,188 | Clayton Richard | Hiroki Kuroda | Clayton Richard | Hiroki Kuroda | | 435 | 341 | 94 |
| 2010-07-29 | vs LAN | 100 | W 3-2 | 58-42 | 1 | 42,075 | Mat Latos | Vicente Padilla | Heath Bell | George Sherrill | | 438 | 343 | 95 |
| 2010-07-30 | vs FLO | 101 | L 2-4 | 58-43 | 1 | 30,478 | Wade LeBlanc | Chris Volstad | Chris Volstad | Wade LeBlanc | Leo Nunez | 440 | 347 | 93 |
| 2010-07-31 | vs FLO | 102 | L 3-6 | 58-44 | 1 | 42,072 | Kevin Correia | Ricky Nolasco | Ricky Nolasco | Kevin Correia | Leo Nunez | 443 | 353 | 90 |
| 2010-08-01 | vs FLO | 103 | W 5-4 | 59-44 | 1 | 27,560 | Jon Garland | Josh Johnson | Jon Garland | Josh Johnson | Heath Bell | 448 | 357 | 91 |
| 2010-08-02 | @ LAN | 104 | W 10-5 | 59-45 | 1 | 40,860 | Clayton Richard | Hiroki Kuroda | Clayton Richard | Hiroki Kuroda | | 458 | 362 | 96 |
| 2010-08-03 | @ LAN | 105 | L 1-2 | 59-46 | 1 | 38,886 | Mat Latos | Ted Lilly | Ted Lilly | Mat Latos | Jonathan Broxton | 459 | 364 | 95 |
| 2010-08-04 | @ LAN | 106 | L 0-9 | 59-47 | 1 | 48,988 | Wade LeBlanc | Vicente Padilla | Vicente Padilla | Wade LeBlanc | | 459 | 373 | 86 |
| 2010-08-05 | @ LAN | 107 | W 5-0 | 60-47 | 1 | 44,739 | Kevin Correia | Chad Billingsley | Kevin Correia | Chad Billingsley | Heath Bell | 464 | 373 | 91 |
| 2010-08-06 | @ ARI | 108 | L 1-2 | 60-48 | 1 | 22,168 | Jon Garland | Daniel Hudson | Daniel Hudson | Jon Garland | Aaron Heilman | 465 | 375 | 90 |
| 2010-08-07 | @ ARI | 109 | L 5-6 | 60-49 | 1 | 48,946 | Clayton Richard | Rodrigo Lopez | Aaron Heilman | Luke Gregerson | | 470 | 381 | 89 |
| 2010-08-08 | @ ARI | 110 | W 10-1 | 61-49 | 1 | 27,856 | Mat Latos | Joe Saunders | Mat Latos | Joe Saunders | | 480 | 382 | 98 |
| 2010-08-10 | vs PIT | 111 | W 4-1 | 62-49 | 1 | 23,249 | Wade LeBlanc | Jeff Karstens | Wade LeBlanc | Jeff Karstens | Heath Bell | 484 | 383 | 101 |
| 2010-08-11 | vs PIT | 112 | W 8-5 | 63-49 | 1 | 28,335 | Kevin Correia | James McDonald | Kevin Correia | James McDonald | Heath Bell | 492 | 388 | 104 |
| 2010-08-12 | vs PIT | 113 | W 3-0 | 64-49 | 1 | 25,897 | Jon Garland | Zach Duke | Jon Garland | Zach Duke | Heath Bell | 495 | 388 | 107 |
| 2010-08-13 | @ SFN | 114 | W 3-2 | 65-49 | 1 | 42,722 | Clayton Richard | Jonathan Sanchez | Clayton Richard | Jonathan Sanchez | Heath Bell | 498 | 390 | 108 |
| 2010-08-14 | @ SFN | 115 | L 2-3 | 65-50 | 1 | 42,293 | Mat Latos | Madison Bumgarner | Santiago Casilla | Tim Stauffer | | 500 | 393 | 107 |
| 2010-08-15 | @ SFN | 116 | W 8-2 | 66-50 | 1 | 42,834 | Wade LeBlanc | Tim Lincecum | Wade LeBlanc | Tim Lincecum | | 508 | 395 | 113 |
| 2010-08-16 | @ CHN | 117 | W 9-5 | 67-50 | 1 | 36,814 | Kevin Correia | Tom Gorzelanny | Kevin Correia | Tom Gorzelanny | | 517 | 400 | 117 |
| 2010-08-17 | @ CHN | 118 | W 1-0 | 68-50 | 1 | 33,664 | Jon Garland | Randy Wells | Jon Garland | Randy Wells | Heath Bell | 518 | 400 | 118 |
| 2010-08-18 | @ CHN | 119 | W 5-1 | 69-50 | 1 | 33,267 | Clayton Richard | Casey Coleman | Clayton Richard | Casey Coleman | | 523 | 401 | 122 |
| 2010-08-19 | @ CHN | 120 | W 5-3 | 70-50 | 1 | 30,687 | Mat Latos | Carlos Zambrano | Mat Latos | Sean Marshall | Heath Bell | 528 | 404 | 124 |
| 2010-08-20 | @ MIL | 121 | L 6-10 | 71-50 | 1 | 27,976 | Wade LeBlanc | Yovani Gallardo | Chris Capuano | Wade LeBlanc | | 534 | 414 | 120 |
| 2010-08-21 | @ MIL | 122 | L 5-6 | 71-51 | 1 | 40,056 | Kevin Correia | Chris Narveson | Mike McClendon | Kevin Correia | John Axford | 539 | 420 | 119 |
| 2010-08-22 | @ MIL | 123 | W 7-3 | 72-51 | 1 | 32,126 | Jon Garland | Manny Parra | Jon Garland | Manny Parra | | 546 | 423 | 123 |
| 2010-08-24 | vs ARI | 124 | W 5-0 | 73-51 | 1 | 20,075 | Clayton Richard | Rodrigo Lopez | Clayton Richard | Rodrigo Lopez | | 551 | 423 | 128 |
| 2010-08-25 | vs ARI | 125 | W 9-3 | 74-51 | 1 | 21,966 | Wade LeBlanc | Joe Saunders | Wade LeBlanc | Joe Saunders | | 560 | 426 | 134 |
| 2010-08-26 | vs ARI | 126 | L 5-11 | 75-51 | 1 | 20,983 | Kevin Correia | Ian Kennedy | Ian Kennedy | Kevin Correia | | 565 | 437 | 128 |
| 2010-08-27 | vs PHI | 127 | L 2-3 | 75-52 | 1 | 34,233 | Mat Latos | Roy Oswalt | Chad Durbin | Ernesto Frieri | | 567 | 440 | 127 |
| 2010-08-28 | vs PHI | 128 | L 1-3 | 75-53 | 1 | 37,424 | Jon Garland | Joe Blanton | Joe Blanton | Jon Garland | Brad Lidge | 568 | 443 | 125 |
| 2010-08-29 | vs PHI | 129 | L 0-5 | 75-54 | 1 | 30,528 | Clayton Richard | Cole Hamels | Cole Hamels | Clayton Richard | | 568 | 448 | 120 |
| 2010-08-30 | @ ARI | 130 | L 2-7 | 75-55 | 1 | 17,829 | Wade LeBlanc | Joe Saunders | Joe Saunders | Wade LeBlanc | | 570 | 455 | 115 |
| 2010-08-31 | @ ARI | 131 | L 4-7 | 75-56 | 1 | 16,250 | Kevin Correia | Ian Kennedy | Ian Kennedy | Kevin Correia | Juan Gutierrez | 574 | 462 | 112 |
| 2010-09-01 | @ ARI | 132 | L 2-5 | 75-57 | 1 | 17,599 | Mat Latos | Barry Enright | Barry Enright | Luke Gregerson | Juan Gutierrez | 576 | 467 | 109 |
| 2010-09-03 | vs COL | 133 | L 3-4 | 75-58 | 1 | 21,877 | Cory Luebke | Aaron Cook | Aaron Cook | Cory Luebke | Huston Street | 579 | 471 | 108 |
| 2010-09-04 | vs COL | 134 | L 2-6 | 75-59 | 1 | 26,168 | Jon Garland | Jason Hammel | Jason Hammel | Jon Garland | | 581 | 477 | 104 |
| 2010-09-05 | vs COL | 135 | L 2-4 | 75-60 | 1 | 23,250 | Clayton Richard | Jorge de la Rosa | Jorge de la Rosa | Tim Stauffer | Huston Street | 583 | 481 | 102 |
| 2010-09-06 | vs LAN | 136 | W 4-2 | 76-60 | 1 | 23,574 | Tim Stauffer | Vicente Padilla | Mike Adams | Vicente Padilla | Heath Bell | 587 | 483 | 104 |
| 2010-09-07 | vs LAN | 137 | W 2-1 | 77-60 | 1 | 20,071 | Mat Latos | Clayton Kershaw | Mat Latos | Clayton Kershaw | Heath Bell | 589 | 484 | 105 |
| 2010-09-08 | vs LAN | 138 | W 4-0 | 78-60 | 1 | 20,851 | Cory Luebke | Chad Billingsley | Cory Luebke | Chad Billingsley | Luke Gregerson | 593 | 484 | 109 |
| 2010-09-09 | vs SFN | 139 | L 3-7 | 78-61 | 1 | 28,456 | Jon Garland | Matt Cain | Matt Cain | Jon Garland | | 596 | 491 | 105 |
| 2010-09-10 | vs SFN | 140 | L 0-1 | 78-62 | 1 | 33,662 | Clayton Richard | Jonathan Sanchez | Santiago Casilla | Clayton Richard | Brian Wilson | 596 | 492 | 104 |
| 2010-09-11 | vs SFN | 141 | W 1-0 | 79-62 | 1 | 41,123 | Tim Stauffer | Madison Bumgarner | Tim Stauffer | Madison Bumgarner | Heath Bell | 597 | 492 | 105 |
| 2010-09-12 | vs SFN | 142 | L 1-6 | 79-63 | 1 | 33,876 | Mat Latos | Tim Lincecum | Tim Lincecum | Mat Latos | | 598 | 498 | 100 |
| 2010-09-13 | @ COL | 143 | W 6-4 | 80-63 | 1 | 34,089 | Cory Luebke | Jeff Francis | Ernesto Frieri | Jeff Francis | Heath Bell | 604 | 502 | 102 |
| 2010-09-14 | @ COL | 144 | W 7-6 | 81-63 | 1 | 40,532 | Jon Garland | Jason Hammel | Jon Garland | Jason Hammel | Heath Bell | 611 | 508 | 103 |
| 2010-09-15 | @ COL | 145 | L 6-9 | 81-64 | 1 | 30,218 | Clayton Richard | Jorge de la Rosa | Jorge de la Rosa | Clayton Richard | Huston Street | 617 | 517 | 100 |
| 2010-09-16 | @ SLN | 146 | L 0-4 | 81-65 | 1 | 38,252 | Tim Stauffer | Jake Westbrook | Jake Westbrook | Tim Stauffer | | 617 | 521 | 96 |
| 2010-09-17 | @ SLN | 147 | L 4-14 | 82-65 | 1 | 37,806 | Mat Latos | Kyle Lohse | Kyle Lohse | Mat Latos | | 621 | 535 | 86 |
| 2010-09-18 | @ SLN | 148 | W 8-4 | 83-65 | 1 | 40,205 | Chris Young | Jeff Suppan | Mike Adams | Kyle McClellan | | 629 | 539 | 90 |
| 2010-09-19 | @ SLN | 149 | L 1-4 | 83-66 | 1 | 37,885 | Jon Garland | Adam Wainwright | Adam Wainwright | Jon Garland | Ryan Franklin | 630 | 543 | 87 |
| 2010-09-21 | @ LAN | 150 | W 6-0 | 84-66 | 1 | 44,166 | Clayton Richard | Chad Billingsley | Clayton Richard | Chad Billingsley | | 636 | 543 | 93 |
| 2010-09-22 | @ LAN | 151 | W 3-1 | 85-66 | 1 | 33,728 | Tim Stauffer | Ted Lilly | Tim Stauffer | Ted Lilly | Heath Bell | 639 | 544 | 95 |
| 2010-09-23 | @ LAN | 152 | L 1-3 | 85-67 | 1 | 33,040 | Mat Latos | Hiroki Kuroda | Hiroki Kuroda | Mat Latos | Hong-Chih Kuo | 640 | 547 | 93 |
| 2010-09-24 | vs CIN | 153 | W 4-3 | 86-67 | 1 | 35,310 | Chris Young | Bronson Arroyo | Luke Gregerson | Arthur Rhodes | Heath Bell | 644 | 550 | 94 |
| 2010-09-25 | vs CIN | 154 | W 4-3 | 87-67 | 1 | 35,124 | Jon Garland | Travis Wood | Heath Bell | Aroldis Chapman | | 648 | 553 | 95 |
| 2010-09-26 | vs CIN | 155 | L 2-12 | 88-67 | 1 | 26,131 | Clayton Richard | Homer Bailey | Homer Bailey | Clayton Richard | | 650 | 565 | 85 |
| 2010-09-27 | vs CHN | 156 | L 0-1 | 88-68 | 1 | 22,739 | Tim Stauffer | Carlos Zambrano | Carlos Zambrano | Tim Stauffer | Carlos Marmol | 650 | 566 | 84 |
| 2010-09-28 | vs CHN | 157 | L 2-5 | 88-69 | 1 | 27,619 | Mat Latos | Ryan Dempster | Ryan Dempster | Mat Latos | Carlos Marmol | 652 | 571 | 81 |
| 2010-09-29 | vs CHN | 158 | W 3-0 | 89-69 | 1 | 29,400 | Chris Young | Randy Wells | Chris Young | Randy Wells | Heath Bell | 655 | 571 | 84 |
| 2010-09-30 | vs CHN | 159 | L 0-1 | 89-70 | 1 | 28,576 | Jon Garland | Tom Gorzelanny | Sean Marshall | Heath Bell | Carlos Marmol | 655 | 572 | 83 |
| 2010-10-01 | @ SFN | 160 | W 6-4 | 90-70 | 1 | 42,409 | Clayton Richard | Matt Cain | Clayton Richard | Matt Cain | Heath Bell | 661 | 576 | 85 |
| 2010-10-02 | @ SFN | 161 | W 4-2 | 91-70 | 1 | 42,653 | Tim Stauffer | Barry Zito | Tim Stauffer | Barry Zito | Heath Bell | 665 | 578 | 87 |
| 2010-10-03 | @ SFN | 162 | L 0-3 | 91-71 | 1 | 42,822 | Mat Latos | Jonathan Sanchez | Jonathan Sanchez | Mat Latos | Brian Wilson | 665 | 581 | 84 |