| 2010-04-05 | vs LAN | 1 | W 11-5 | 0-1 | 5 | 39,024 | Zach Duke | Vicente Padilla | Zach Duke | Vicente Padilla | | 11 | 5 | 6 |
| 2010-04-07 | vs LAN | 2 | W 4-3 | 1-1 | 4 | 31,061 | Ross Ohlendorf | Clayton Kershaw | Brendan Donnelly | Ramon Ortiz | | 15 | 8 | 7 |
| 2010-04-08 | vs LAN | 3 | L 2-10 | 2-1 | 3 | 9,352 | Paul Maholm | Chad Billingsley | Chad Billingsley | Paul Maholm | | 17 | 18 | -1 |
| 2010-04-09 | @ ARI | 4 | L 1-9 | 2-2 | 4 | 21,316 | Charlie Morton | Rodrigo Lopez | Rodrigo Lopez | Charlie Morton | | 18 | 27 | -9 |
| 2010-04-10 | @ ARI | 5 | W 6-3 | 3-2 | 3 | 22,400 | Zach Duke | Dan Haren | Zach Duke | Dan Haren | Octavio Dotel | 24 | 30 | -6 |
| 2010-04-11 | @ ARI | 6 | L 6-15 | 4-2 | 2 | 21,093 | Daniel McCutchen | Edwin Jackson | Edwin Jackson | Daniel McCutchen | | 30 | 45 | -15 |
| 2010-04-12 | @ SFN | 7 | L 3-9 | 4-3 | 3 | 26,011 | Brian Burres | Barry Zito | Barry Zito | Brian Burres | | 33 | 54 | -21 |
| 2010-04-13 | @ SFN | 8 | W 6-5 | 5-3 | 2 | 28,030 | Paul Maholm | Matt Cain | Evan Meek | Jeremy Affeldt | Octavio Dotel | 39 | 59 | -20 |
| 2010-04-14 | @ SFN | 9 | L 0-6 | 5-4 | 4 | 29,028 | Charlie Morton | Jonathan Sanchez | Jonathan Sanchez | Charlie Morton | | 39 | 65 | -26 |
| 2010-04-16 | vs CIN | 10 | W 4-3 | 6-4 | 2 | 14,758 | Zach Duke | Mike Leake | Octavio Dotel | Nick Masset | | 43 | 68 | -25 |
| 2010-04-17 | vs CIN | 11 | W 5-4 | 7-4 | 1 | 25,196 | Daniel McCutchen | Johnny Cueto | Jack Taschner | Francisco Cordero | | 48 | 72 | -24 |
| 2010-04-18 | vs CIN | 12 | W 5-3 | 8-4 | 1 | 13,860 | Paul Maholm | Bronson Arroyo | Paul Maholm | Bronson Arroyo | Octavio Dotel | 53 | 75 | -22 |
| 2010-04-20 | vs MIL | 13 | L 1-8 | 8-5 | 1 | 9,386 | Charlie Morton | David Bush | David Bush | Charlie Morton | | 54 | 83 | -29 |
| 2010-04-21 | vs MIL | 14 | L 0-8 | 8-6 | 2 | 12,192 | Zach Duke | Yovani Gallardo | Yovani Gallardo | Zach Duke | | 54 | 91 | -37 |
| 2010-04-22 | vs MIL | 15 | L 0-20 | 8-7 | 2 | 13,634 | Daniel McCutchen | Randy Wolf | Randy Wolf | Daniel McCutchen | | 54 | 111 | -57 |
| 2010-04-23 | @ HOU | 16 | L 3-4 | 8-8 | 3 | 30,018 | Paul Maholm | Roy Oswalt | Roy Oswalt | Paul Maholm | Matt Lindstrom | 57 | 115 | -58 |
| 2010-04-24 | @ HOU | 17 | L 2-5 | 8-9 | 5 | 30,562 | Chris Jakubauskas | Wandy Rodriguez | Wandy Rodriguez | Chris Jakubauskas | Matt Lindstrom | 59 | 120 | -61 |
| 2010-04-25 | @ HOU | 18 | L 3-10 | 9-9 | 3 | 27,210 | Charlie Morton | Brett Myers | Brett Myers | Charlie Morton | | 62 | 130 | -68 |
| 2010-04-26 | @ MIL | 19 | L 3-17 | 10-9 | 2 | 25,892 | Zach Duke | Yovani Gallardo | Yovani Gallardo | Zach Duke | | 65 | 147 | -82 |
| 2010-04-27 | @ MIL | 20 | W 7-3 | 11-9 | 3 | 28,991 | Jeff Karstens | Randy Wolf | Brendan Donnelly | Trevor Hoffman | | 72 | 150 | -78 |
| 2010-04-28 | @ MIL | 21 | W 6-5 | 12-9 | 3 | 28,401 | Paul Maholm | Chris Narveson | D.J. Carrasco | Manny Parra | | 78 | 155 | -77 |
| 2010-04-29 | @ LAN | 22 | W 2-0 | 13-9 | 2 | 40,185 | Brian Burres | Clayton Kershaw | Brian Burres | Clayton Kershaw | Evan Meek | 80 | 155 | -75 |
| 2010-04-30 | @ LAN | 23 | L 2-6 | 13-10 | 2 | 46,775 | Charlie Morton | Chad Billingsley | Chad Billingsley | Charlie Morton | | 82 | 161 | -79 |
| 2010-05-01 | @ LAN | 24 | L 1-5 | 13-11 | 3 | 40,483 | Zach Duke | Carlos Monasterios | Ramon Ortiz | Zach Duke | | 83 | 166 | -83 |
| 2010-05-02 | @ LAN | 25 | L 3-9 | 13-12 | 3 | 39,339 | Jeff Karstens | Hiroki Kuroda | Hiroki Kuroda | Jeff Karstens | | 86 | 175 | -89 |
| 2010-05-04 | vs CHN | 26 | W 3-2 | 14-12 | 3 | 10,972 | Paul Maholm | Ryan Dempster | Paul Maholm | Ryan Dempster | Octavio Dotel | 89 | 177 | -88 |
| 2010-05-05 | vs CHN | 27 | W 4-2 | 15-12 | 3 | 11,053 | Charlie Morton | Ted Lilly | Charlie Morton | Ted Lilly | Octavio Dotel | 93 | 179 | -86 |
| 2010-05-06 | vs CHN | 28 | W 11-1 | 16-12 | 1 | 11,085 | Brian Burres | Randy Wells | Brian Burres | Randy Wells | | 104 | 180 | -76 |
| 2010-05-07 | vs SLN | 29 | L 3-4 | 16-13 | 3 | 16,473 | Zach Duke | Chris Carpenter | Ryan Franklin | Evan Meek | | 107 | 184 | -77 |
| 2010-05-08 | vs SLN | 30 | W 2-0 | 17-13 | 2 | 25,047 | Jeff Karstens | Jaime Garcia | Jeff Karstens | Jaime Garcia | Octavio Dotel | 109 | 184 | -75 |
| 2010-05-09 | vs SLN | 31 | L 4-11 | 18-13 | 2 | 17,342 | Paul Maholm | Adam Wainwright | Adam Wainwright | Paul Maholm | | 113 | 195 | -82 |
| 2010-05-10 | vs CIN | 32 | L 1-2 | 18-14 | 2 | 9,045 | Ross Ohlendorf | Bronson Arroyo | Bronson Arroyo | Ross Ohlendorf | Francisco Cordero | 114 | 197 | -83 |
| 2010-05-11 | vs CIN | 33 | L 0-9 | 18-15 | 2 | 9,027 | Charlie Morton | Johnny Cueto | Johnny Cueto | Charlie Morton | | 114 | 206 | -92 |
| 2010-05-12 | vs CIN | 34 | L 0-5 | 18-16 | 2 | 20,064 | Zach Duke | Homer Bailey | Homer Bailey | Zach Duke | | 114 | 211 | -97 |
| 2010-05-14 | @ CHN | 35 | W 10-6 | 18-17 | 2 | 39,082 | Brian Burres | Tom Gorzelanny | Evan Meek | Carlos Zambrano | | 124 | 217 | -93 |
| 2010-05-15 | @ CHN | 36 | W 4-3 | 19-17 | 2 | 41,336 | Paul Maholm | Ryan Dempster | Paul Maholm | Ryan Dempster | Octavio Dotel | 128 | 220 | -92 |
| 2010-05-16 | @ CHN | 37 | L 3-4 | 19-18 | 2 | 40,636 | Ross Ohlendorf | Ted Lilly | Sean Marshall | D.J. Carrasco | Carlos Marmol | 131 | 224 | -93 |
| 2010-05-17 | @ PHI | 38 | L 2-12 | 20-18 | 2 | 45,371 | Charlie Morton | Kyle Kendrick | Kyle Kendrick | Charlie Morton | | 133 | 236 | -103 |
| 2010-05-18 | @ PHI | 39 | W 2-1 | 21-18 | 2 | 45,007 | Zach Duke | Roy Halladay | Zach Duke | Roy Halladay | Octavio Dotel | 135 | 237 | -102 |
| 2010-05-19 | vs MIL | 40 | W 6-4 | 22-18 | 2 | 9,526 | Brian Burres | Randy Wolf | Javier Lopez | Randy Wolf | Octavio Dotel | 141 | 241 | -100 |
| 2010-05-20 | vs MIL | 41 | L 3-4 | 22-19 | 2 | 13,975 | Paul Maholm | Chris Narveson | Chris Narveson | Paul Maholm | Carlos Villanueva | 144 | 245 | -101 |
| 2010-05-21 | vs ATL | 42 | L 0-7 | 22-20 | 2 | 22,470 | Ross Ohlendorf | Tim Hudson | Tim Hudson | Ross Ohlendorf | | 144 | 252 | -108 |
| 2010-05-22 | vs ATL | 43 | L 2-4 | 22-21 | 3 | 26,519 | Charlie Morton | Derek Lowe | Derek Lowe | Charlie Morton | Billy Wagner | 146 | 256 | -110 |
| 2010-05-23 | vs ATL | 44 | W 3-2 | 23-21 | 3 | 23,045 | Zach Duke | Kris Medlen | Octavio Dotel | Takashi Saito | | 149 | 258 | -109 |
| 2010-05-24 | @ CIN | 45 | L 5-7 | 23-22 | 3 | 13,385 | Brian Burres | Aaron Harang | Aaron Harang | Brian Burres | Francisco Cordero | 154 | 265 | -111 |
| 2010-05-25 | @ CIN | 46 | W 2-1 | 24-22 | 2 | 14,471 | Paul Maholm | Mike Leake | Joel Hanrahan | Nick Masset | Octavio Dotel | 156 | 266 | -110 |
| 2010-05-26 | @ CIN | 47 | L 0-4 | 24-23 | 2 | 18,137 | Ross Ohlendorf | Bronson Arroyo | Bronson Arroyo | Ross Ohlendorf | | 156 | 270 | -114 |
| 2010-05-27 | @ CIN | 48 | L 2-8 | 24-24 | 3 | 16,834 | Charlie Morton | Johnny Cueto | Johnny Cueto | Charlie Morton | | 158 | 278 | -120 |
| 2010-05-28 | @ ATL | 49 | L 3-7 | 24-25 | 3 | 23,442 | Zach Duke | Derek Lowe | Derek Lowe | Zach Duke | | 161 | 285 | -124 |
| 2010-05-29 | @ ATL | 50 | L 3-6 | 24-26 | 4 | 29,134 | Brian Burres | Kris Medlen | Kris Medlen | Brian Burres | Billy Wagner | 164 | 291 | -127 |
| 2010-05-30 | @ ATL | 51 | L 2-5 | 24-27 | 4 | 31,078 | Paul Maholm | Kenshin Kawakami | Takashi Saito | Joel Hanrahan | Billy Wagner | 166 | 296 | -130 |
| 2010-05-31 | vs CHN | 52 | W 2-1 | 25-27 | 3 | 20,235 | Ross Ohlendorf | Randy Wells | Evan Meek | Sean Marshall | Octavio Dotel | 168 | 297 | -129 |
| 2010-06-01 | vs CHN | 53 | W 3-2 | 26-27 | 3 | 11,334 | Jeff Karstens | Ted Lilly | Joel Hanrahan | Ted Lilly | Octavio Dotel | 171 | 299 | -128 |
| 2010-06-04 | vs SFN | 54 | L 4-6 | 26-28 | 3 | 17,817 | Zach Duke | Jonathan Sanchez | Jonathan Sanchez | Zach Duke | Brian Wilson | 175 | 305 | -130 |
| 2010-06-05 | vs SFN | 55 | W 6-3 | 27-28 | 3 | 36,687 | Paul Maholm | Todd Wellemeyer | Paul Maholm | Todd Wellemeyer | | 181 | 308 | -127 |
| 2010-06-06 | vs SFN | 56 | L 5-6 | 27-29 | 3 | 24,068 | Ross Ohlendorf | Tim Lincecum | Brian Wilson | Octavio Dotel | Santiago Casilla | 186 | 314 | -128 |
| 2010-06-07 | vs CHN | 57 | L 1-6 | 27-30 | 3 | 12,768 | Dana Eveland | Carlos Silva | Carlos Silva | Dana Eveland | Sean Marshall | 187 | 320 | -133 |
| 2010-06-08 | @ WAS | 58 | L 2-5 | 27-31 | 3 | 40,315 | Jeff Karstens | Stephen Strasburg | Stephen Strasburg | Jeff Karstens | Matt Capps | 189 | 325 | -136 |
| 2010-06-09 | @ WAS | 59 | L 5-7 | 27-32 | 5 | 18,876 | Brad Lincoln | John Lannan | Drew Storen | D.J. Carrasco | Matt Capps | 194 | 332 | -138 |
| 2010-06-10 | @ WAS | 60 | L 2-4 | 27-33 | 5 | 21,767 | Zach Duke | Livan Hernandez | Livan Hernandez | Zach Duke | Tyler Clippard | 196 | 336 | -140 |
| 2010-06-11 | @ DET | 61 | L 2-6 | 27-34 | 6 | 33,236 | Ross Ohlendorf | Justin Verlander | Justin Verlander | Ross Ohlendorf | | 198 | 342 | -144 |
| 2010-06-12 | @ DET | 62 | L 3-4 | 27-35 | 6 | 34,501 | Paul Maholm | Jeremy Bonderman | Phil Coke | Brendan Donnelly | | 201 | 346 | -145 |
| 2010-06-13 | @ DET | 63 | L 3-4 | 27-36 | 6 | 31,243 | Jeff Karstens | Armando Galarraga | Brad Thomas | Javier Lopez | Jose Valverde | 204 | 350 | -146 |
| 2010-06-15 | vs CHA | 64 | L 4-6 | 27-37 | 6 | 12,693 | Brad Lincoln | Freddy Garcia | Freddy Garcia | Brad Lincoln | Bobby Jenks | 208 | 356 | -148 |
| 2010-06-16 | vs CHA | 65 | L 2-7 | 27-38 | 6 | 15,218 | Zach Duke | John Danks | John Danks | Zach Duke | | 210 | 363 | -153 |
| 2010-06-17 | vs CHA | 66 | L 4-5 | 27-39 | 6 | 23,170 | Ross Ohlendorf | Mark Buehrle | Mark Buehrle | Ross Ohlendorf | Bobby Jenks | 214 | 368 | -154 |
| 2010-06-18 | vs CLE | 67 | L 3-4 | 27-40 | 6 | 28,478 | Paul Maholm | Fausto Carmona | Fausto Carmona | Paul Maholm | Kerry Wood | 217 | 372 | -155 |
| 2010-06-19 | vs CLE | 68 | W 6-4 | 28-40 | 6 | 38,008 | Jeff Karstens | David Huff | Jeff Karstens | David Huff | Octavio Dotel | 223 | 376 | -153 |
| 2010-06-20 | vs CLE | 69 | W 5-3 | 29-40 | 6 | 29,845 | Brad Lincoln | Justin Masterson | Brendan Donnelly | Jensen Lewis | Octavio Dotel | 228 | 379 | -151 |
| 2010-06-22 | @ TEX | 70 | L 3-6 | 29-41 | 6 | 23,083 | Ross Ohlendorf | Tommy Hunter | Tommy Hunter | Ross Ohlendorf | Neftali Feliz | 231 | 385 | -154 |
| 2010-06-23 | @ TEX | 71 | L 3-13 | 30-41 | 6 | 33,646 | Paul Maholm | Dustin Nippert | Alexi Ogando | Paul Maholm | Matt Harrison | 234 | 398 | -164 |
| 2010-06-24 | @ TEX | 72 | L 5-6 | 30-42 | 6 | 19,567 | Jeff Karstens | Scott Feldman | Frank Francisco | Steven Jackson | | 239 | 404 | -165 |
| 2010-06-25 | @ OAK | 73 | L 4-14 | 31-42 | 6 | 11,154 | Brad Lincoln | Ben Sheets | Ben Sheets | Brad Lincoln | | 243 | 418 | -175 |
| 2010-06-26 | @ OAK | 74 | L 0-5 | 31-43 | 6 | 25,068 | Daniel McCutchen | Trevor Cahill | Trevor Cahill | Daniel McCutchen | | 243 | 423 | -180 |
| 2010-06-27 | @ OAK | 75 | L 2-3 | 31-44 | 6 | 15,238 | Ross Ohlendorf | Gio Gonzalez | Craig Breslow | Evan Meek | Andrew Bailey | 245 | 426 | -181 |
| 2010-06-28 | @ CHN | 76 | W 2-1 | 32-44 | 6 | 38,512 | Paul Maholm | Randy Wells | Paul Maholm | Andrew Cashner | Octavio Dotel | 247 | 427 | -180 |
| 2010-06-29 | @ CHN | 77 | L 1-3 | 32-45 | 6 | 36,914 | Jeff Karstens | Ted Lilly | Ted Lilly | Jeff Karstens | Carlos Marmol | 248 | 430 | -182 |
| 2010-06-30 | @ CHN | 78 | W 2-0 | 33-45 | 6 | 37,391 | Brad Lincoln | Tom Gorzelanny | Brad Lincoln | Andrew Cashner | Octavio Dotel | 250 | 430 | -180 |
| 2010-07-01 | vs PHI | 79 | W 3-2 | 34-45 | 6 | 25,323 | Daniel McCutchen | Cole Hamels | Daniel McCutchen | Cole Hamels | Octavio Dotel | 253 | 432 | -179 |
| 2010-07-02 | vs PHI | 80 | W 2-0 | 35-45 | 6 | 30,339 | Ross Ohlendorf | Jamie Moyer | Ross Ohlendorf | Jamie Moyer | Octavio Dotel | 255 | 432 | -177 |
| 2010-07-03 | vs PHI | 81 | L 4-12 | 36-45 | 6 | 38,052 | Paul Maholm | Kyle Kendrick | Kyle Kendrick | Paul Maholm | | 259 | 444 | -185 |
| 2010-07-04 | vs PHI | 82 | W 8-5 | 37-45 | 4 | 28,698 | Jeff Karstens | Joe Blanton | Evan Meek | Jose Contreras | Octavio Dotel | 267 | 449 | -182 |
| 2010-07-06 | @ HOU | 83 | L 2-6 | 37-46 | 5 | 23,210 | Brad Lincoln | Wandy Rodriguez | Wandy Rodriguez | Brad Lincoln | | 269 | 455 | -186 |
| 2010-07-07 | @ HOU | 84 | L 3-6 | 37-47 | 5 | 23,123 | Daniel McCutchen | Brian Moehler | Casey Daigle | Daniel McCutchen | Matt Lindstrom | 272 | 461 | -189 |
| 2010-07-08 | @ HOU | 85 | L 0-2 | 37-48 | 5 | 24,416 | Ross Ohlendorf | Roy Oswalt | Roy Oswalt | Ross Ohlendorf | | 272 | 463 | -191 |
| 2010-07-09 | @ MIL | 86 | L 4-5 | 37-49 | 6 | 27,767 | Paul Maholm | Doug Davis | John Axford | Evan Meek | | 276 | 468 | -192 |
| 2010-07-10 | @ MIL | 87 | L 3-4 | 37-50 | 6 | 38,588 | Jeff Karstens | David Bush | David Bush | Jeff Karstens | John Axford | 279 | 472 | -193 |
| 2010-07-11 | @ MIL | 88 | L 5-6 | 37-51 | 6 | 34,598 | Brad Lincoln | Randy Wolf | John Axford | Octavio Dotel | | 284 | 478 | -194 |
| 2010-07-16 | vs HOU | 89 | L 2-5 | 37-52 | 6 | 23,273 | Zach Duke | Brett Myers | Brett Myers | Zach Duke | Matt Lindstrom | 286 | 483 | -197 |
| 2010-07-17 | vs HOU | 90 | W 12-6 | 37-53 | 6 | 36,665 | Ross Ohlendorf | Bud Norris | Javier Lopez | Bud Norris | | 298 | 489 | -191 |
| 2010-07-18 | vs HOU | 91 | W 9-0 | 38-53 | 6 | 16,638 | Paul Maholm | Roy Oswalt | Paul Maholm | Roy Oswalt | | 307 | 489 | -182 |
| 2010-07-19 | vs MIL | 92 | L 1-3 | 38-54 | 6 | 12,375 | Jeff Karstens | Chris Capuano | Chris Capuano | Jeff Karstens | John Axford | 308 | 492 | -184 |
| 2010-07-20 | vs MIL | 93 | W 11-9 | 38-55 | 6 | 13,202 | Brad Lincoln | David Bush | D.J. Carrasco | David Bush | Octavio Dotel | 319 | 501 | -182 |
| 2010-07-21 | vs MIL | 94 | W 15-3 | 38-56 | 6 | 13,532 | Zach Duke | Randy Wolf | Zach Duke | Randy Wolf | | 334 | 504 | -170 |
| 2010-07-22 | vs MIL | 95 | L 2-3 | 38-57 | 6 | 18,715 | Ross Ohlendorf | Yovani Gallardo | Yovani Gallardo | Ross Ohlendorf | John Axford | 336 | 507 | -171 |
| 2010-07-23 | vs SDN | 96 | L 3-5 | 38-58 | 6 | 18,611 | Paul Maholm | Kevin Correia | Kevin Correia | Paul Maholm | Heath Bell | 339 | 512 | -173 |
| 2010-07-24 | vs SDN | 97 | L 2-9 | 38-59 | 6 | 36,967 | Jeff Karstens | Mat Latos | Mat Latos | Jeff Karstens | | 341 | 521 | -180 |
| 2010-07-25 | vs SDN | 98 | L 3-6 | 38-60 | 6 | 18,800 | Brad Lincoln | Wade LeBlanc | Wade LeBlanc | Brad Lincoln | Heath Bell | 344 | 527 | -183 |
| 2010-07-27 | @ COL | 99 | W 4-2 | 39-60 | 6 | 46,608 | Zach Duke | Jorge de la Rosa | Zach Duke | Jorge de la Rosa | Octavio Dotel | 348 | 529 | -181 |
| 2010-07-28 | @ COL | 100 | W 6-2 | 40-60 | 6 | 35,128 | Ross Ohlendorf | Aaron Cook | Sean Gallagher | Aaron Cook | | 354 | 531 | -177 |
| 2010-07-29 | @ COL | 101 | L 3-9 | 40-61 | 6 | 34,158 | Paul Maholm | Ubaldo Jimenez | Ubaldo Jimenez | Paul Maholm | | 357 | 540 | -183 |
| 2010-07-30 | @ SLN | 102 | L 0-1 | 40-62 | 6 | 44,534 | Jeff Karstens | Chris Carpenter | Ryan Franklin | Javier Lopez | | 357 | 541 | -184 |
| 2010-07-31 | @ SLN | 103 | L 1-11 | 40-63 | 6 | 45,783 | Daniel McCutchen | Jeff Suppan | Jeff Suppan | Daniel McCutchen | | 358 | 552 | -194 |
| 2010-08-01 | @ SLN | 104 | L 1-9 | 40-64 | 6 | 43,338 | Zach Duke | Adam Wainwright | Adam Wainwright | Zach Duke | | 359 | 561 | -202 |
| 2010-08-02 | vs CIN | 105 | L 0-4 | 40-65 | 6 | 15,172 | Ross Ohlendorf | Travis Wood | Travis Wood | Ross Ohlendorf | | 359 | 565 | -206 |
| 2010-08-03 | vs CIN | 106 | W 7-6 | 41-65 | 6 | 13,623 | Paul Maholm | Mike Leake | Paul Maholm | Mike Leake | Joel Hanrahan | 366 | 571 | -205 |
| 2010-08-04 | vs CIN | 107 | L 4-9 | 41-66 | 6 | 20,420 | Jeff Karstens | Johnny Cueto | Johnny Cueto | Jeff Karstens | | 370 | 580 | -210 |
| 2010-08-05 | vs COL | 108 | W 5-1 | 42-66 | 6 | 17,131 | James McDonald | Jeff Francis | James McDonald | Jeff Francis | | 375 | 581 | -206 |
| 2010-08-06 | vs COL | 109 | L 3-6 | 42-67 | 6 | 30,711 | Zach Duke | Jason Hammel | Jason Hammel | Chan Ho Park | Huston Street | 378 | 587 | -209 |
| 2010-08-07 | vs COL | 110 | W 8-7 | 43-67 | 6 | 38,147 | Ross Ohlendorf | Jorge de la Rosa | Sean Gallagher | Huston Street | | 386 | 594 | -208 |
| 2010-08-08 | vs COL | 111 | L 4-8 | 43-68 | 6 | 22,716 | Paul Maholm | Esmil Rogers | Esmil Rogers | Paul Maholm | | 390 | 602 | -212 |
| 2010-08-10 | @ SDN | 112 | L 1-4 | 43-69 | 6 | 23,249 | Jeff Karstens | Wade LeBlanc | Wade LeBlanc | Jeff Karstens | Heath Bell | 391 | 606 | -215 |
| 2010-08-11 | @ SDN | 113 | L 5-8 | 43-70 | 6 | 28,335 | James McDonald | Kevin Correia | Kevin Correia | James McDonald | Heath Bell | 396 | 614 | -218 |
| 2010-08-12 | @ SDN | 114 | L 0-3 | 43-71 | 6 | 25,897 | Zach Duke | Jon Garland | Jon Garland | Zach Duke | Heath Bell | 396 | 617 | -221 |
| 2010-08-13 | @ HOU | 115 | L 1-4 | 43-72 | 6 | 36,124 | Ross Ohlendorf | Brett Myers | Wilton Lopez | Evan Meek | Brandon Lyon | 397 | 621 | -224 |
| 2010-08-14 | @ HOU | 116 | L 2-3 | 43-73 | 6 | 31,608 | Paul Maholm | Bud Norris | Bud Norris | Paul Maholm | Brandon Lyon | 399 | 624 | -225 |
| 2010-08-15 | @ HOU | 117 | L 2-8 | 43-74 | 6 | 34,372 | Jeff Karstens | J.A. Happ | J.A. Happ | Jeff Karstens | | 401 | 632 | -231 |
| 2010-08-16 | vs FLO | 118 | W 7-1 | 44-74 | 6 | 13,396 | James McDonald | Chris Volstad | James McDonald | Chris Volstad | | 408 | 633 | -225 |
| 2010-08-17 | vs FLO | 119 | L 0-6 | 44-75 | 6 | 14,156 | Zach Duke | Ricky Nolasco | Ricky Nolasco | Zach Duke | | 408 | 639 | -231 |
| 2010-08-18 | vs FLO | 120 | L 2-3 | 44-76 | 6 | 12,242 | Ross Ohlendorf | Josh Johnson | Josh Johnson | Ross Ohlendorf | Leo Nunez | 410 | 642 | -232 |
| 2010-08-19 | vs FLO | 121 | L 2-4 | 44-77 | 6 | 15,783 | Paul Maholm | Alejandro Sanabia | Alejandro Sanabia | Paul Maholm | Leo Nunez | 412 | 646 | -234 |
| 2010-08-20 | vs NYN | 122 | L 2-7 | 44-78 | 6 | 23,695 | Jeff Karstens | Mike Pelfrey | Mike Pelfrey | Jeff Karstens | | 414 | 653 | -239 |
| 2010-08-21 | vs NYN | 123 | L 1-5 | 44-79 | 6 | 28,759 | James McDonald | Jonathon Niese | Jonathon Niese | James McDonald | | 415 | 658 | -243 |
| 2010-08-22 | vs NYN | 124 | W 2-1 | 45-79 | 6 | 24,730 | Zach Duke | Johan Santana | Zach Duke | Johan Santana | Joel Hanrahan | 417 | 659 | -242 |
| 2010-08-23 | vs SLN | 125 | L 2-10 | 46-79 | 6 | 12,393 | Ross Ohlendorf | Kyle Lohse | Kyle Lohse | Ross Ohlendorf | | 419 | 669 | -250 |
| 2010-08-24 | vs SLN | 126 | W 4-3 | 47-79 | 6 | 13,302 | Paul Maholm | Adam Wainwright | Joel Hanrahan | Adam Wainwright | Evan Meek | 423 | 672 | -249 |
| 2010-08-25 | vs SLN | 127 | W 5-2 | 48-79 | 6 | 12,686 | Daniel McCutchen | Jake Westbrook | Daniel McCutchen | Jake Westbrook | | 428 | 674 | -246 |
| 2010-08-27 | @ MIL | 128 | L 2-7 | 48-80 | 6 | 32,130 | James McDonald | Chris Narveson | Chris Narveson | James McDonald | | 430 | 681 | -251 |
| 2010-08-28 | @ MIL | 129 | L 7-8 | 48-81 | 6 | 37,782 | Zach Duke | Chris Capuano | Kameron Loe | Wil Ledezma | | 437 | 689 | -252 |
| 2010-08-29 | @ MIL | 130 | L 4-8 | 48-82 | 6 | 35,733 | Charlie Morton | David Bush | David Bush | Charlie Morton | Trevor Hoffman | 441 | 697 | -256 |
| 2010-08-30 | @ CHN | 131 | L 2-14 | 49-82 | 6 | 29,538 | Paul Maholm | Carlos Zambrano | Carlos Zambrano | Paul Maholm | | 443 | 711 | -268 |
| 2010-08-31 | @ CHN | 132 | W 14-7 | 49-83 | 6 | 31,369 | Jeff Karstens | Ryan Dempster | Jeff Karstens | Ryan Dempster | | 457 | 718 | -261 |
| 2010-09-01 | @ CHN | 133 | L 3-5 | 49-84 | 6 | 33,555 | James McDonald | Tom Gorzelanny | Thomas Diamond | James McDonald | Carlos Marmol | 460 | 723 | -263 |
| 2010-09-03 | vs WAS | 134 | W 8-5 | 50-84 | 6 | 19,734 | Zach Duke | Livan Hernandez | Zach Duke | Livan Hernandez | Joel Hanrahan | 468 | 728 | -260 |
| 2010-09-04 | vs WAS | 135 | L 2-9 | 50-85 | 6 | 30,263 | Paul Maholm | John Lannan | John Lannan | Paul Maholm | | 470 | 737 | -267 |
| 2010-09-05 | vs WAS | 136 | L 1-8 | 50-86 | 6 | 18,057 | Charlie Morton | Jason Marquis | Jason Marquis | Charlie Morton | | 471 | 745 | -274 |
| 2010-09-06 | vs ATL | 137 | W 3-1 | 51-86 | 6 | 15,330 | Brian Burres | Tommy Hanson | Brian Burres | Tommy Hanson | Joel Hanrahan | 474 | 746 | -272 |
| 2010-09-07 | vs ATL | 138 | W 5-0 | 52-86 | 6 | 11,070 | James McDonald | Tim Hudson | James McDonald | Tim Hudson | | 479 | 746 | -267 |
| 2010-09-08 | vs ATL | 139 | L 3-9 | 52-87 | 6 | 13,113 | Zach Duke | Derek Lowe | Derek Lowe | Zach Duke | | 482 | 755 | -273 |
| 2010-09-10 | @ CIN | 140 | L 3-4 | 52-88 | 6 | 24,908 | Paul Maholm | Homer Bailey | Jordan Smith | Wil Ledezma | | 485 | 759 | -274 |
| 2010-09-11 | @ CIN | 141 | L 4-5 | 52-89 | 6 | 36,101 | Charlie Morton | Edinson Volquez | Francisco Cordero | Justin Thomas | | 489 | 764 | -275 |
| 2010-09-12 | @ CIN | 142 | W 3-1 | 53-89 | 6 | 26,617 | Brian Burres | Johnny Cueto | Chan Ho Park | Francisco Cordero | Joel Hanrahan | 492 | 765 | -273 |
| 2010-09-13 | @ NYN | 143 | L 0-1 | 53-90 | 6 | 24,384 | James McDonald | Dillon Gee | Hisanori Takahashi | Chan Ho Park | | 492 | 766 | -274 |
| 2010-09-14 | @ NYN | 144 | L 1-9 | 53-91 | 6 | 27,438 | Zach Duke | R.A. Dickey | R.A. Dickey | Zach Duke | | 493 | 775 | -282 |
| 2010-09-15 | @ NYN | 145 | L 7-8 | 53-92 | 6 | 29,000 | Paul Maholm | Jenrry Mejia | Raul Valdes | Paul Maholm | Hisanori Takahashi | 500 | 783 | -283 |
| 2010-09-16 | @ NYN | 146 | L 2-6 | 53-93 | 6 | 28,790 | Charlie Morton | Mike Pelfrey | Mike Pelfrey | Wil Ledezma | | 502 | 789 | -287 |
| 2010-09-17 | vs ARI | 147 | W 4-3 | 54-93 | 6 | 22,939 | Brian Burres | Ian Kennedy | Evan Meek | Esmerling Vasquez | | 506 | 792 | -286 |
| 2010-09-18 | vs ARI | 148 | W 9-6 | 55-93 | 6 | 25,981 | James McDonald | Barry Enright | James McDonald | Barry Enright | | 515 | 798 | -283 |
| 2010-09-19 | vs ARI | 149 | W 4-3 | 56-93 | 6 | 18,331 | Zach Duke | Daniel Hudson | Joel Hanrahan | Aaron Heilman | Evan Meek | 519 | 801 | -282 |
| 2010-09-21 | vs SLN | 150 | W 5-2 | 57-93 | 6 | 15,478 | Paul Maholm | Jake Westbrook | Paul Maholm | Jake Westbrook | Evan Meek | 524 | 803 | -279 |
| 2010-09-22 | vs SLN | 151 | W 11-6 | 57-94 | 6 | 11,785 | Charlie Morton | Kyle Lohse | Charlie Morton | Kyle Lohse | | 535 | 809 | -274 |
| 2010-09-23 | vs SLN | 152 | L 2-9 | 57-95 | 6 | 15,802 | Brian Burres | Jeff Suppan | Jeff Suppan | Brian Burres | | 537 | 818 | -281 |
| 2010-09-24 | vs HOU | 153 | L 7-10 | 58-95 | 6 | 22,279 | James McDonald | Brett Myers | Brett Myers | Chris Leroux | Brandon Lyon | 544 | 828 | -284 |
| 2010-09-25 | vs HOU | 154 | W 6-4 | 59-95 | 6 | 25,350 | Zach Duke | Bud Norris | Zach Duke | Bud Norris | Joel Hanrahan | 550 | 832 | -282 |
| 2010-09-26 | vs HOU | 155 | W 9-3 | 60-95 | 6 | 23,208 | Paul Maholm | J.A. Happ | Paul Maholm | J.A. Happ | | 559 | 835 | -276 |
| 2010-09-27 | @ SLN | 156 | L 4-6 | 60-96 | 6 | 38,592 | Charlie Morton | Kyle Lohse | Dennys Reyes | Sean Gallagher | Kyle McClellan | 563 | 841 | -278 |
| 2010-09-28 | @ SLN | 157 | W 7-2 | 61-96 | 6 | 38,315 | Brian Burres | Jeff Suppan | Brian Burres | Jeff Suppan | | 570 | 843 | -273 |
| 2010-09-29 | @ SLN | 158 | L 1-4 | 61-97 | 7 | 38,112 | James McDonald | P.J. Walters | P.J. Walters | James McDonald | | 571 | 847 | -276 |
| 2010-09-30 | @ FLO | 159 | L 9-11 | 62-97 | 6 | 21,021 | Zach Duke | Chris Volstad | Chris Volstad | Zach Duke | Leo Nunez | 580 | 858 | -278 |
| 2010-10-01 | @ FLO | 160 | W 5-1 | 63-97 | 6 | 23,124 | Daniel McCutchen | Adalberto Mendez | Chan Ho Park | Adalberto Mendez | | 585 | 859 | -274 |
| 2010-10-02 | @ FLO | 161 | L 0-2 | 63-98 | 6 | 25,332 | Charlie Morton | Jorge Sosa | Brian Sanches | Charlie Morton | Clay Hensley | 585 | 861 | -276 |
| 2010-10-03 | @ FLO | 162 | L 2-5 | 63-99 | 6 | 31,803 | Brian Burres | Anibal Sanchez | Anibal Sanchez | Brian Burres | Clay Hensley | 587 | 866 | -279 |