| 2010-04-05 | vs SDN | 1 | W 6-3 | 1-0 | 1 | 49,192 | Dan Haren | Jon Garland | Dan Haren | Jon Garland | | 6 | 3 | 3 |
| 2010-04-06 | vs SDN | 2 | L 3-6 | 1-1 | 3 | 19,177 | Edwin Jackson | Chris Young | Chris Young | Edwin Jackson | Heath Bell | 9 | 9 | 0 |
| 2010-04-07 | vs SDN | 3 | W 5-3 | 2-1 | 1 | 17,673 | Ian Kennedy | Kevin Correia | Blaine Boyer | Kevin Correia | Chad Qualls | 14 | 12 | 2 |
| 2010-04-09 | vs PIT | 4 | W 9-1 | 3-1 | 1 | 21,316 | Rodrigo Lopez | Charlie Morton | Rodrigo Lopez | Charlie Morton | | 23 | 13 | 10 |
| 2010-04-10 | vs PIT | 5 | L 3-6 | 3-2 | 1 | 22,400 | Dan Haren | Zach Duke | Zach Duke | Dan Haren | Octavio Dotel | 26 | 19 | 7 |
| 2010-04-11 | vs PIT | 6 | W 15-6 | 3-3 | 2 | 21,093 | Edwin Jackson | Daniel McCutchen | Edwin Jackson | Daniel McCutchen | | 41 | 25 | 16 |
| 2010-04-13 | @ LAN | 7 | L 5-9 | 3-4 | 2 | 56,000 | Ian Kennedy | Clayton Kershaw | Clayton Kershaw | Ian Kennedy | | 46 | 34 | 12 |
| 2010-04-14 | @ LAN | 8 | W 9-7 | 4-4 | 2 | 44,621 | Rodrigo Lopez | Chad Billingsley | Leo Rosales | Russ Ortiz | | 55 | 41 | 14 |
| 2010-04-15 | @ LAN | 9 | L 5-6 | 4-5 | 2 | 39,697 | Dan Haren | Hiroki Kuroda | Jonathan Broxton | Blaine Boyer | | 60 | 47 | 13 |
| 2010-04-16 | @ SDN | 10 | L 3-6 | 4-6 | 2 | 26,632 | Edwin Jackson | Jon Garland | Heath Bell | Juan Gutierrez | | 63 | 53 | 10 |
| 2010-04-17 | @ SDN | 11 | L 0-5 | 4-7 | 3 | 31,324 | Kris Benson | Kevin Correia | Kevin Correia | Kris Benson | | 63 | 58 | 5 |
| 2010-04-18 | @ SDN | 12 | L 3-5 | 4-8 | 5 | 20,634 | Ian Kennedy | Wade LeBlanc | Edward Mujica | Aaron Heilman | Heath Bell | 66 | 63 | 3 |
| 2010-04-19 | vs SLN | 13 | L 2-4 | 4-9 | 5 | 24,167 | Rodrigo Lopez | Brad Penny | Brad Penny | Blaine Boyer | Ryan Franklin | 68 | 67 | 1 |
| 2010-04-20 | vs SLN | 14 | W 9-7 | 5-9 | 4 | 19,855 | Dan Haren | Kyle Lohse | Dan Haren | Mitchell Boggs | Chad Qualls | 77 | 74 | 3 |
| 2010-04-21 | vs SLN | 15 | L 4-9 | 5-10 | 4 | 19,165 | Edwin Jackson | Chris Carpenter | Jason Motte | Chad Qualls | | 81 | 83 | -2 |
| 2010-04-23 | vs PHI | 16 | W 7-4 | 6-10 | 3 | 25,980 | Kris Benson | Cole Hamels | Kris Benson | Cole Hamels | Chad Qualls | 88 | 87 | 1 |
| 2010-04-24 | vs PHI | 17 | L 2-3 | 6-11 | 5 | 33,323 | Ian Kennedy | Nelson Figueroa | Jose Contreras | Juan Gutierrez | Ryan Madson | 90 | 90 | 0 |
| 2010-04-25 | vs PHI | 18 | W 8-6 | 7-11 | 4 | 29,296 | Rodrigo Lopez | Kyle Kendrick | Leo Rosales | David Herndon | Chad Qualls | 98 | 96 | 2 |
| 2010-04-26 | @ COL | 19 | W 5-3 | 8-11 | 3 | 20,308 | Dan Haren | Jason Hammel | Dan Haren | Jason Hammel | Chad Qualls | 103 | 99 | 4 |
| 2010-04-27 | @ COL | 20 | L 1-12 | 8-12 | 4 | 24,112 | Edwin Jackson | Ubaldo Jimenez | Ubaldo Jimenez | Edwin Jackson | | 104 | 111 | -7 |
| 2010-04-28 | @ COL | 21 | W 12-11 | 9-12 | 3 | 23,773 | Kris Benson | Greg Smith | Bob Howry | Franklin Morales | Juan Gutierrez | 116 | 122 | -6 |
| 2010-04-29 | @ CHN | 22 | W 13-5 | 9-13 | 3 | 36,850 | Ian Kennedy | Ted Lilly | Ian Kennedy | Ted Lilly | | 129 | 127 | 2 |
| 2010-04-30 | @ CHN | 23 | L 5-11 | 10-13 | 3 | 37,800 | Rodrigo Lopez | Randy Wells | Randy Wells | Rodrigo Lopez | | 134 | 138 | -4 |
| 2010-05-01 | @ CHN | 24 | L 5-7 | 10-14 | 3 | 40,368 | Dan Haren | Carlos Silva | Sean Marshall | Juan Gutierrez | Carlos Marmol | 139 | 145 | -6 |
| 2010-05-02 | @ CHN | 25 | L 5-10 | 11-14 | 3 | 38,144 | Edwin Jackson | Tom Gorzelanny | Tom Gorzelanny | Edwin Jackson | | 144 | 155 | -11 |
| 2010-05-03 | @ HOU | 26 | W 9-1 | 12-14 | 3 | 20,370 | Cesar Valdez | Felipe Paulino | Cesar Valdez | Felipe Paulino | | 153 | 156 | -3 |
| 2010-05-04 | @ HOU | 27 | W 1-0 | 13-14 | 3 | 22,661 | Ian Kennedy | Roy Oswalt | Ian Kennedy | Roy Oswalt | Chad Qualls | 154 | 156 | -2 |
| 2010-05-05 | @ HOU | 28 | L 2-4 | 13-15 | 4 | 21,030 | Rodrigo Lopez | Brett Myers | Matt Lindstrom | Juan Gutierrez | | 156 | 160 | -4 |
| 2010-05-06 | @ HOU | 29 | W 6-3 | 14-15 | 4 | 21,019 | Dan Haren | Wandy Rodriguez | Dan Haren | Wandy Rodriguez | | 162 | 163 | -1 |
| 2010-05-07 | vs MIL | 30 | L 2-3 | 14-16 | 4 | 27,067 | Edwin Jackson | Yovani Gallardo | Yovani Gallardo | Edwin Jackson | Trevor Hoffman | 164 | 166 | -2 |
| 2010-05-08 | vs MIL | 31 | L 3-17 | 15-16 | 4 | 26,877 | Cesar Valdez | Randy Wolf | Randy Wolf | Cesar Valdez | | 167 | 183 | -16 |
| 2010-05-09 | vs MIL | 32 | L 1-6 | 15-17 | 4 | 25,358 | Ian Kennedy | Chris Narveson | Chris Narveson | Ian Kennedy | | 168 | 189 | -21 |
| 2010-05-10 | vs LAN | 33 | L 3-7 | 15-18 | 4 | 19,863 | Rodrigo Lopez | Chad Billingsley | Chad Billingsley | Rodrigo Lopez | | 171 | 196 | -25 |
| 2010-05-11 | vs LAN | 34 | L 3-13 | 16-18 | 4 | 21,030 | Dan Haren | John Ely | John Ely | Dan Haren | | 174 | 209 | -35 |
| 2010-05-12 | vs LAN | 35 | L 3-6 | 16-19 | 4 | 22,714 | Edwin Jackson | Hiroki Kuroda | Hiroki Kuroda | Edwin Jackson | Jonathan Broxton | 177 | 215 | -38 |
| 2010-05-14 | @ ATL | 36 | L 5-6 | 16-20 | 4 | 30,657 | Ian Kennedy | Kenshin Kawakami | Billy Wagner | Chad Qualls | | 182 | 221 | -39 |
| 2010-05-15 | @ ATL | 37 | W 11-1 | 17-20 | 5 | 32,718 | Rodrigo Lopez | Tommy Hanson | Rodrigo Lopez | Tommy Hanson | | 193 | 222 | -29 |
| 2010-05-16 | @ ATL | 38 | L 1-13 | 17-21 | 5 | 31,758 | Dan Haren | Tim Hudson | Tim Hudson | Dan Haren | | 194 | 235 | -41 |
| 2010-05-17 | @ FLO | 39 | W 5-1 | 18-21 | 5 | 10,870 | Edwin Jackson | Chris Volstad | Edwin Jackson | Chris Volstad | | 199 | 236 | -37 |
| 2010-05-18 | @ FLO | 40 | L 0-8 | 18-22 | 5 | 13,289 | Billy Buckner | Josh Johnson | Josh Johnson | Billy Buckner | | 199 | 244 | -45 |
| 2010-05-19 | vs SFN | 41 | W 13-1 | 19-22 | 4 | 17,073 | Ian Kennedy | Todd Wellemeyer | Ian Kennedy | Todd Wellemeyer | | 212 | 245 | -33 |
| 2010-05-20 | vs SFN | 42 | W 8-7 | 20-22 | 4 | 18,607 | Rodrigo Lopez | Tim Lincecum | Aaron Heilman | Jeremy Affeldt | Chad Qualls | 220 | 252 | -32 |
| 2010-05-21 | vs TOR | 43 | W 8-6 | 21-22 | 4 | 19,531 | Dan Haren | Brandon Morrow | Dan Haren | Brandon Morrow | Chad Qualls | 228 | 258 | -30 |
| 2010-05-22 | vs TOR | 44 | W 8-5 | 22-22 | 4 | 32,746 | Edwin Jackson | Dana Eveland | Edwin Jackson | Dana Eveland | Chad Qualls | 236 | 263 | -27 |
| 2010-05-23 | vs TOR | 45 | L 4-12 | 23-22 | 4 | 23,148 | Billy Buckner | Shaun Marcum | Shaun Marcum | Billy Buckner | | 240 | 275 | -35 |
| 2010-05-25 | @ COL | 46 | L 2-3 | 23-23 | 4 | 28,370 | Ian Kennedy | Jhoulis Chacin | Jhoulis Chacin | Ian Kennedy | Manuel Corpas | 242 | 278 | -36 |
| 2010-05-26 | @ COL | 47 | L 3-7 | 23-24 | 4 | 26,320 | Rodrigo Lopez | Ubaldo Jimenez | Ubaldo Jimenez | Rodrigo Lopez | | 245 | 285 | -40 |
| 2010-05-27 | @ COL | 48 | L 2-8 | 23-25 | 5 | 28,353 | Dan Haren | Jason Hammel | Jason Hammel | Dan Haren | | 247 | 293 | -46 |
| 2010-05-28 | @ SFN | 49 | L 0-5 | 23-26 | 5 | 31,495 | Edwin Jackson | Matt Cain | Matt Cain | Edwin Jackson | | 247 | 298 | -51 |
| 2010-05-29 | @ SFN | 50 | L 1-12 | 23-27 | 5 | 37,400 | Billy Buckner | Jonathan Sanchez | Jonathan Sanchez | Billy Buckner | | 248 | 310 | -62 |
| 2010-05-30 | @ SFN | 51 | L 5-6 | 23-28 | 5 | 41,394 | Ian Kennedy | Todd Wellemeyer | Brian Wilson | Carlos Rosa | | 253 | 316 | -63 |
| 2010-05-31 | @ LAN | 52 | L 4-5 | 23-29 | 5 | 45,325 | Rodrigo Lopez | Chad Billingsley | Jonathan Broxton | Esmerling Vasquez | | 257 | 321 | -64 |
| 2010-06-01 | @ LAN | 53 | L 0-1 | 23-30 | 5 | 36,533 | Dan Haren | John Ely | Jeff Weaver | Juan Gutierrez | | 257 | 322 | -65 |
| 2010-06-02 | @ LAN | 54 | L 0-1 | 23-31 | 5 | 35,355 | Edwin Jackson | Carlos Monasterios | Travis Schlichting | Cesar Valdez | | 257 | 323 | -66 |
| 2010-06-04 | vs COL | 55 | W 7-6 | 24-31 | 5 | 25,290 | Ian Kennedy | Aaron Cook | Chad Qualls | Manuel Corpas | | 264 | 329 | -65 |
| 2010-06-05 | vs COL | 56 | W 4-3 | 25-31 | 5 | 28,138 | Dontrelle Willis | Jhoulis Chacin | Dontrelle Willis | Jhoulis Chacin | Chad Qualls | 268 | 332 | -64 |
| 2010-06-06 | vs COL | 57 | L 2-3 | 25-32 | 5 | 20,793 | Rodrigo Lopez | Ubaldo Jimenez | Ubaldo Jimenez | Rodrigo Lopez | Manuel Corpas | 270 | 335 | -65 |
| 2010-06-07 | vs ATL | 58 | W 7-4 | 26-32 | 5 | 17,731 | Dan Haren | Derek Lowe | Dan Haren | Derek Lowe | Chad Qualls | 277 | 339 | -62 |
| 2010-06-08 | vs ATL | 59 | L 5-7 | 26-33 | 5 | 17,052 | Edwin Jackson | Kris Medlen | Jonny Venters | Esmerling Vasquez | Billy Wagner | 282 | 346 | -64 |
| 2010-06-09 | vs ATL | 60 | W 2-1 | 27-33 | 5 | 19,138 | Ian Kennedy | Kenshin Kawakami | Aaron Heilman | Peter Moylan | Chad Qualls | 284 | 347 | -63 |
| 2010-06-10 | vs ATL | 61 | L 7-11 | 28-33 | 5 | 26,969 | Dontrelle Willis | Tommy Hanson | Peter Moylan | Chad Qualls | | 291 | 358 | -67 |
| 2010-06-11 | vs SLN | 62 | L 2-5 | 28-34 | 5 | 20,629 | Rodrigo Lopez | Jaime Garcia | Jaime Garcia | Rodrigo Lopez | Ryan Franklin | 293 | 363 | -70 |
| 2010-06-12 | vs SLN | 63 | W 7-2 | 29-34 | 5 | 30,017 | Dan Haren | Adam Ottavino | Dan Haren | Adam Ottavino | | 300 | 365 | -65 |
| 2010-06-13 | vs SLN | 64 | W 7-5 | 30-34 | 4 | 23,922 | Edwin Jackson | Chris Carpenter | Esmerling Vasquez | Kyle McClellan | | 307 | 370 | -63 |
| 2010-06-15 | @ BOS | 65 | L 3-6 | 30-35 | 4 | 37,459 | Ian Kennedy | Clay Buchholz | Clay Buchholz | Ian Kennedy | Jonathan Papelbon | 310 | 376 | -66 |
| 2010-06-16 | @ BOS | 66 | L 2-6 | 30-36 | 4 | 37,452 | Rodrigo Lopez | Jon Lester | Jon Lester | Rodrigo Lopez | Jonathan Papelbon | 312 | 382 | -70 |
| 2010-06-17 | @ BOS | 67 | L 5-8 | 30-37 | 5 | 37,544 | Dan Haren | John Lackey | John Lackey | Dan Haren | | 317 | 390 | -73 |
| 2010-06-18 | @ DET | 68 | L 5-7 | 30-38 | 5 | 37,438 | Dontrelle Willis | Armando Galarraga | Phil Coke | Chad Qualls | Jose Valverde | 322 | 397 | -75 |
| 2010-06-19 | @ DET | 69 | W 6-5 | 31-38 | 5 | 40,681 | Edwin Jackson | Rick Porcello | Edwin Jackson | Rick Porcello | Aaron Heilman | 328 | 402 | -74 |
| 2010-06-20 | @ DET | 70 | L 1-3 | 31-39 | 5 | 41,417 | Ian Kennedy | Max Scherzer | Max Scherzer | Ian Kennedy | Jose Valverde | 329 | 405 | -76 |
| 2010-06-21 | vs NYA | 71 | W 10-4 | 31-40 | 5 | 47,229 | Rodrigo Lopez | A.J. Burnett | Rodrigo Lopez | A.J. Burnett | | 339 | 409 | -70 |
| 2010-06-22 | vs NYA | 72 | L 3-9 | 31-41 | 5 | 45,776 | Dan Haren | Andy Pettitte | Andy Pettitte | Dan Haren | | 342 | 418 | -76 |
| 2010-06-23 | vs NYA | 73 | L 5-6 | 31-42 | 5 | 46,325 | Dontrelle Willis | Javier Vazquez | Mariano Rivera | Carlos Rosa | | 347 | 424 | -77 |
| 2010-06-25 | @ TBA | 74 | W 1-0 | 32-42 | 5 | 18,918 | Edwin Jackson | Jeff Niemann | Edwin Jackson | Jeff Niemann | | 348 | 424 | -76 |
| 2010-06-26 | @ TBA | 75 | L 3-5 | 32-43 | 5 | 23,945 | Ian Kennedy | David Price | David Price | Ian Kennedy | Rafael Soriano | 351 | 429 | -78 |
| 2010-06-27 | @ TBA | 76 | W 2-1 | 33-43 | 5 | 25,442 | Rodrigo Lopez | Wade Davis | Rodrigo Lopez | Wade Davis | Aaron Heilman | 353 | 430 | -77 |
| 2010-06-28 | @ SLN | 77 | L 5-6 | 33-44 | 5 | 41,578 | Dan Haren | Chris Carpenter | Jason Motte | Aaron Heilman | | 358 | 436 | -78 |
| 2010-06-29 | @ SLN | 78 | L 0-8 | 33-45 | 5 | 38,736 | Dontrelle Willis | Adam Wainwright | Adam Wainwright | Dontrelle Willis | | 358 | 444 | -86 |
| 2010-06-30 | @ SLN | 79 | W 4-2 | 34-45 | 5 | 36,962 | Barry Enright | Jeff Suppan | Barry Enright | Jeff Suppan | Aaron Heilman | 362 | 446 | -84 |
| 2010-07-02 | vs LAN | 80 | W 12-5 | 34-46 | 5 | 23,155 | Edwin Jackson | Hiroki Kuroda | Edwin Jackson | Hiroki Kuroda | | 374 | 451 | -77 |
| 2010-07-03 | vs LAN | 81 | L 1-14 | 34-47 | 5 | 44,169 | Rodrigo Lopez | Clayton Kershaw | Clayton Kershaw | Rodrigo Lopez | | 375 | 465 | -90 |
| 2010-07-04 | vs LAN | 82 | L 1-3 | 34-48 | 5 | 26,517 | Dan Haren | Chad Billingsley | Hong-Chih Kuo | Aaron Heilman | Jonathan Broxton | 376 | 468 | -92 |
| 2010-07-05 | vs CHN | 83 | L 4-9 | 34-49 | 5 | 26,250 | Ian Kennedy | Tom Gorzelanny | Tom Gorzelanny | Ian Kennedy | | 380 | 477 | -97 |
| 2010-07-06 | vs CHN | 84 | L 4-6 | 34-50 | 5 | 20,067 | Barry Enright | Carlos Silva | Carlos Silva | Barry Enright | Carlos Marmol | 384 | 483 | -99 |
| 2010-07-07 | vs CHN | 85 | L 3-8 | 34-51 | 5 | 20,914 | Edwin Jackson | Ryan Dempster | Ryan Dempster | Edwin Jackson | | 387 | 491 | -104 |
| 2010-07-08 | vs FLO | 86 | W 10-4 | 34-52 | 5 | 16,664 | Rodrigo Lopez | Anibal Sanchez | Rodrigo Lopez | Anibal Sanchez | | 397 | 495 | -98 |
| 2010-07-09 | vs FLO | 87 | L 2-3 | 34-53 | 5 | 18,117 | Dan Haren | Ricky Nolasco | Ricky Nolasco | Dan Haren | Leo Nunez | 399 | 498 | -99 |
| 2010-07-10 | vs FLO | 88 | W 5-4 | 35-53 | 5 | 21,627 | Ian Kennedy | Nate Robertson | Ian Kennedy | Nate Robertson | Juan Gutierrez | 404 | 502 | -98 |
| 2010-07-11 | vs FLO | 89 | L 0-2 | 35-54 | 5 | 21,037 | Barry Enright | Alejandro Sanabia | Burke Badenhop | Barry Enright | Leo Nunez | 404 | 504 | -100 |
| 2010-07-16 | @ SDN | 90 | L 1-12 | 35-55 | 5 | 33,177 | Dan Haren | Jon Garland | Jon Garland | Dan Haren | | 405 | 516 | -111 |
| 2010-07-17 | @ SDN | 91 | L 5-8 | 35-56 | 5 | 40,011 | Rodrigo Lopez | Clayton Richard | Clayton Richard | Rodrigo Lopez | Heath Bell | 410 | 524 | -114 |
| 2010-07-18 | @ SDN | 92 | L 4-6 | 35-57 | 5 | 25,363 | Edwin Jackson | Kevin Correia | Kevin Correia | Edwin Jackson | Heath Bell | 414 | 530 | -116 |
| 2010-07-19 | vs NYN | 93 | W 13-2 | 35-58 | 5 | 18,253 | Ian Kennedy | Mike Pelfrey | Ian Kennedy | Mike Pelfrey | | 427 | 532 | -105 |
| 2010-07-20 | vs NYN | 94 | W 3-2 | 36-58 | 5 | 18,749 | Barry Enright | R.A. Dickey | Barry Enright | R.A. Dickey | Juan Gutierrez | 430 | 534 | -104 |
| 2010-07-21 | vs NYN | 95 | W 4-3 | 37-58 | 5 | 18,223 | Dan Haren | Jonathon Niese | Blaine Boyer | Fernando Nieve | | 434 | 537 | -103 |
| 2010-07-22 | vs SFN | 96 | L 0-3 | 37-59 | 5 | 17,230 | Rodrigo Lopez | Matt Cain | Matt Cain | Rodrigo Lopez | Brian Wilson | 434 | 540 | -106 |
| 2010-07-23 | vs SFN | 97 | L 4-7 | 37-60 | 5 | 22,512 | Edwin Jackson | Jonathan Sanchez | Chris Ray | Edwin Jackson | Brian Wilson | 438 | 547 | -109 |
| 2010-07-24 | vs SFN | 98 | L 4-10 | 38-60 | 5 | 32,774 | Ian Kennedy | Madison Bumgarner | Madison Bumgarner | Ian Kennedy | | 442 | 557 | -115 |
| 2010-07-25 | vs SFN | 99 | L 2-3 | 38-61 | 5 | 31,278 | Barry Enright | Tim Lincecum | Sergio Romo | Esmerling Vasquez | Brian Wilson | 444 | 560 | -116 |
| 2010-07-27 | @ PHI | 100 | L 5-9 | 38-62 | 5 | 44,379 | Rodrigo Lopez | Cole Hamels | David Herndon | Jordan Norberto | | 449 | 569 | -120 |
| 2010-07-28 | @ PHI | 101 | L 1-7 | 38-63 | 5 | 45,048 | Edwin Jackson | Roy Halladay | Roy Halladay | Edwin Jackson | | 450 | 576 | -126 |
| 2010-07-29 | @ PHI | 102 | L 2-3 | 38-64 | 5 | 45,232 | Joe Saunders | Kyle Kendrick | Jose Contreras | Esmerling Vasquez | | 452 | 579 | -127 |
| 2010-07-30 | @ NYN | 103 | W 9-6 | 39-64 | 5 | 34,280 | Ian Kennedy | Mike Pelfrey | Ian Kennedy | Raul Valdes | Aaron Heilman | 461 | 585 | -124 |
| 2010-07-31 | @ NYN | 104 | L 4-5 | 39-65 | 5 | 35,287 | Barry Enright | Hisanori Takahashi | Francisco Rodriguez | Juan Gutierrez | | 465 | 590 | -125 |
| 2010-08-01 | @ NYN | 105 | W 14-1 | 40-65 | 5 | 35,014 | Daniel Hudson | Jonathon Niese | Daniel Hudson | Jonathon Niese | | 479 | 591 | -112 |
| 2010-08-02 | vs WAS | 106 | L 1-3 | 40-66 | 5 | 16,793 | Rodrigo Lopez | Livan Hernandez | Livan Hernandez | Rodrigo Lopez | Sean Burnett | 480 | 594 | -114 |
| 2010-08-03 | vs WAS | 107 | W 6-1 | 41-66 | 5 | 17,164 | Joe Saunders | Scott Olsen | Joe Saunders | Scott Olsen | | 486 | 595 | -109 |
| 2010-08-04 | vs WAS | 108 | L 2-7 | 41-67 | 5 | 15,670 | Ian Kennedy | Craig Stammen | Craig Stammen | Ian Kennedy | | 488 | 602 | -114 |
| 2010-08-05 | vs WAS | 109 | W 8-4 | 42-67 | 5 | 16,638 | Barry Enright | Ross Detwiler | Barry Enright | Ross Detwiler | | 496 | 606 | -110 |
| 2010-08-06 | vs SDN | 110 | W 2-1 | 43-67 | 5 | 22,168 | Daniel Hudson | Jon Garland | Daniel Hudson | Jon Garland | Aaron Heilman | 498 | 607 | -109 |
| 2010-08-07 | vs SDN | 111 | W 6-5 | 44-67 | 5 | 48,946 | Rodrigo Lopez | Clayton Richard | Aaron Heilman | Luke Gregerson | | 504 | 612 | -108 |
| 2010-08-08 | vs SDN | 112 | L 1-10 | 44-68 | 5 | 27,856 | Joe Saunders | Mat Latos | Mat Latos | Joe Saunders | | 505 | 622 | -117 |
| 2010-08-09 | @ MIL | 113 | W 7-4 | 45-68 | 5 | 29,633 | Ian Kennedy | Chris Narveson | Sam Demel | Trevor Hoffman | Aaron Heilman | 512 | 626 | -114 |
| 2010-08-10 | @ MIL | 114 | W 2-1 | 46-68 | 5 | 35,029 | Barry Enright | Manny Parra | Blaine Boyer | Chris Capuano | Sam Demel | 514 | 627 | -113 |
| 2010-08-11 | @ MIL | 115 | W 8-2 | 47-68 | 5 | 29,611 | Daniel Hudson | David Bush | Daniel Hudson | David Bush | | 522 | 629 | -107 |
| 2010-08-12 | @ MIL | 116 | L 4-8 | 47-69 | 5 | 34,808 | Rodrigo Lopez | Randy Wolf | Randy Wolf | Rodrigo Lopez | John Axford | 526 | 637 | -111 |
| 2010-08-13 | @ WAS | 117 | L 2-4 | 47-70 | 5 | 19,549 | Joe Saunders | John Lannan | John Lannan | Joe Saunders | Sean Burnett | 528 | 641 | -113 |
| 2010-08-14 | @ WAS | 118 | W 9-2 | 48-70 | 5 | 22,400 | Ian Kennedy | Jason Marquis | Ian Kennedy | Jason Marquis | | 537 | 643 | -106 |
| 2010-08-15 | @ WAS | 119 | L 3-5 | 48-71 | 5 | 21,695 | Barry Enright | Stephen Strasburg | Tyler Clippard | Jordan Norberto | Drew Storen | 540 | 648 | -108 |
| 2010-08-17 | vs CIN | 120 | L 2-6 | 48-72 | 5 | 21,502 | Daniel Hudson | Bronson Arroyo | Bronson Arroyo | Daniel Hudson | | 542 | 654 | -112 |
| 2010-08-18 | vs CIN | 121 | L 7-11 | 49-72 | 5 | 15,509 | Rodrigo Lopez | Edinson Volquez | Arthur Rhodes | Aaron Heilman | | 549 | 665 | -116 |
| 2010-08-19 | vs CIN | 122 | L 5-9 | 49-73 | 5 | 17,385 | Joe Saunders | Travis Wood | Travis Wood | Joe Saunders | | 554 | 674 | -120 |
| 2010-08-20 | vs COL | 123 | W 4-3 | 50-73 | 5 | 26,294 | Ian Kennedy | Esmil Rogers | Aaron Heilman | Joe Beimel | | 558 | 677 | -119 |
| 2010-08-21 | vs COL | 124 | W 3-1 | 51-73 | 5 | 37,631 | Barry Enright | Ubaldo Jimenez | Barry Enright | Ubaldo Jimenez | Juan Gutierrez | 561 | 678 | -117 |
| 2010-08-22 | vs COL | 125 | L 0-1 | 51-74 | 5 | 30,397 | Daniel Hudson | Jhoulis Chacin | Jhoulis Chacin | Aaron Heilman | Huston Street | 561 | 679 | -118 |
| 2010-08-24 | @ SDN | 126 | L 0-5 | 51-75 | 5 | 20,075 | Rodrigo Lopez | Clayton Richard | Clayton Richard | Rodrigo Lopez | | 561 | 684 | -123 |
| 2010-08-25 | @ SDN | 127 | L 3-9 | 51-76 | 5 | 21,966 | Joe Saunders | Wade LeBlanc | Wade LeBlanc | Joe Saunders | | 564 | 693 | -129 |
| 2010-08-26 | @ SDN | 128 | W 11-5 | 51-77 | 5 | 20,983 | Ian Kennedy | Kevin Correia | Ian Kennedy | Kevin Correia | | 575 | 698 | -123 |
| 2010-08-27 | @ SFN | 129 | W 6-0 | 52-77 | 5 | 38,013 | Barry Enright | Tim Lincecum | Barry Enright | Tim Lincecum | | 581 | 698 | -117 |
| 2010-08-28 | @ SFN | 130 | W 11-3 | 52-78 | 5 | 41,250 | Daniel Hudson | Barry Zito | Daniel Hudson | Barry Zito | | 592 | 701 | -109 |
| 2010-08-29 | @ SFN | 131 | L 7-9 | 52-79 | 5 | 38,735 | Rodrigo Lopez | Matt Cain | Jeremy Affeldt | Esmerling Vasquez | Brian Wilson | 599 | 710 | -111 |
| 2010-08-30 | vs SDN | 132 | W 7-2 | 53-79 | 5 | 17,829 | Joe Saunders | Wade LeBlanc | Joe Saunders | Wade LeBlanc | | 606 | 712 | -106 |
| 2010-08-31 | vs SDN | 133 | W 7-4 | 54-79 | 5 | 16,250 | Ian Kennedy | Kevin Correia | Ian Kennedy | Kevin Correia | Juan Gutierrez | 613 | 716 | -103 |
| 2010-09-01 | vs SDN | 134 | W 5-2 | 55-79 | 5 | 17,599 | Barry Enright | Mat Latos | Barry Enright | Luke Gregerson | Juan Gutierrez | 618 | 718 | -100 |
| 2010-09-03 | vs HOU | 135 | W 4-3 | 56-79 | 5 | 24,748 | Daniel Hudson | Brett Myers | Aaron Heilman | Wilton Lopez | Juan Gutierrez | 622 | 721 | -99 |
| 2010-09-04 | vs HOU | 136 | L 5-6 | 56-80 | 5 | 31,605 | Joe Saunders | Bud Norris | Mark Melancon | Aaron Heilman | Brandon Lyon | 627 | 727 | -100 |
| 2010-09-05 | vs HOU | 137 | L 2-3 | 56-81 | 5 | 25,416 | Rodrigo Lopez | J.A. Happ | J.A. Happ | Rodrigo Lopez | Brandon Lyon | 629 | 730 | -101 |
| 2010-09-06 | vs SFN | 138 | L 0-2 | 56-82 | 5 | 31,879 | Ian Kennedy | Madison Bumgarner | Santiago Casilla | Aaron Heilman | Brian Wilson | 629 | 732 | -103 |
| 2010-09-07 | vs SFN | 139 | L 3-6 | 56-83 | 5 | 19,417 | Barry Enright | Tim Lincecum | Tim Lincecum | Barry Enright | Jeremy Affeldt | 632 | 738 | -106 |
| 2010-09-08 | vs SFN | 140 | W 3-1 | 57-83 | 5 | 19,972 | Daniel Hudson | Barry Zito | Daniel Hudson | Barry Zito | Juan Gutierrez | 635 | 739 | -104 |
| 2010-09-10 | @ COL | 141 | L 4-13 | 58-83 | 5 | 37,265 | Joe Saunders | Jorge de la Rosa | Jorge de la Rosa | Joe Saunders | | 639 | 752 | -113 |
| 2010-09-11 | @ COL | 142 | L 1-2 | 58-84 | 5 | 48,023 | Rodrigo Lopez | Ubaldo Jimenez | Matt Reynolds | Rodrigo Lopez | Huston Street | 640 | 754 | -114 |
| 2010-09-12 | @ COL | 143 | L 2-4 | 58-85 | 5 | 41,504 | Ian Kennedy | Jhoulis Chacin | Huston Street | Sam Demel | | 642 | 758 | -116 |
| 2010-09-13 | @ CIN | 144 | L 2-7 | 58-86 | 5 | 12,060 | Barry Enright | Bronson Arroyo | Bronson Arroyo | Barry Enright | | 644 | 765 | -121 |
| 2010-09-14 | @ CIN | 145 | W 3-1 | 59-86 | 5 | 16,973 | Daniel Hudson | Travis Wood | Daniel Hudson | Travis Wood | Juan Gutierrez | 647 | 766 | -119 |
| 2010-09-15 | @ CIN | 146 | L 5-7 | 59-87 | 5 | 19,923 | Joe Saunders | Homer Bailey | Matt Maloney | Joe Saunders | Francisco Cordero | 652 | 773 | -121 |
| 2010-09-16 | @ CIN | 147 | W 3-1 | 60-87 | 5 | 22,090 | Rodrigo Lopez | Edinson Volquez | Rodrigo Lopez | Edinson Volquez | Juan Gutierrez | 655 | 774 | -119 |
| 2010-09-17 | @ PIT | 148 | L 3-4 | 60-88 | 5 | 22,939 | Ian Kennedy | Brian Burres | Evan Meek | Esmerling Vasquez | | 658 | 778 | -120 |
| 2010-09-18 | @ PIT | 149 | L 6-9 | 60-89 | 5 | 25,981 | Barry Enright | James McDonald | James McDonald | Barry Enright | | 664 | 787 | -123 |
| 2010-09-19 | @ PIT | 150 | L 3-4 | 60-90 | 5 | 18,331 | Daniel Hudson | Zach Duke | Joel Hanrahan | Aaron Heilman | Evan Meek | 667 | 791 | -124 |
| 2010-09-21 | vs COL | 151 | W 3-1 | 61-90 | 5 | 37,460 | Joe Saunders | Jorge de la Rosa | Joe Saunders | Jorge de la Rosa | Juan Gutierrez | 670 | 792 | -122 |
| 2010-09-22 | vs COL | 152 | W 8-4 | 62-90 | 5 | 29,903 | Rodrigo Lopez | Ubaldo Jimenez | Rodrigo Lopez | Ubaldo Jimenez | Sam Demel | 678 | 796 | -118 |
| 2010-09-23 | vs COL | 153 | W 10-9 | 62-91 | 5 | 30,093 | Ian Kennedy | Jeff Francis | D.J. Carrasco | Jeff Francis | Juan Gutierrez | 688 | 805 | -117 |
| 2010-09-24 | vs LAN | 154 | L 1-3 | 62-92 | 5 | 38,516 | Barry Enright | Clayton Kershaw | Clayton Kershaw | Barry Enright | Kenley Jansen | 689 | 808 | -119 |
| 2010-09-25 | vs LAN | 155 | W 5-2 | 63-92 | 5 | 41,477 | Daniel Hudson | John Ely | Daniel Hudson | John Ely | Juan Gutierrez | 694 | 810 | -116 |
| 2010-09-26 | vs LAN | 156 | W 5-4 | 64-92 | 5 | 37,911 | Joe Saunders | Chad Billingsley | Sam Demel | Jonathan Broxton | Juan Gutierrez | 699 | 814 | -115 |
| 2010-09-28 | @ SFN | 157 | L 2-4 | 64-93 | 5 | 37,449 | Rodrigo Lopez | Jonathan Sanchez | Jonathan Sanchez | Rodrigo Lopez | Brian Wilson | 701 | 818 | -117 |
| 2010-09-29 | @ SFN | 158 | L 1-3 | 64-94 | 5 | 38,228 | Ian Kennedy | Tim Lincecum | Tim Lincecum | Ian Kennedy | Brian Wilson | 702 | 821 | -119 |
| 2010-09-30 | @ SFN | 159 | L 1-4 | 64-95 | 5 | 37,261 | Barry Enright | Madison Bumgarner | Madison Bumgarner | Barry Enright | Ramon Ramirez | 703 | 825 | -122 |
| 2010-10-01 | @ LAN | 160 | W 7-5 | 65-95 | 5 | 36,713 | Zach Kroenke | John Ely | Zach Kroenke | John Ely | Juan Gutierrez | 710 | 830 | -120 |
| 2010-10-02 | @ LAN | 161 | L 2-3 | 65-96 | 5 | 41,918 | Joe Saunders | Chad Billingsley | Chad Billingsley | Joe Saunders | Kenley Jansen | 712 | 833 | -121 |
| 2010-10-03 | @ LAN | 162 | L 1-3 | 65-97 | 5 | 38,007 | Rodrigo Lopez | Ted Lilly | Ted Lilly | Rodrigo Lopez | Hong-Chih Kuo | 713 | 836 | -123 |