| 2010-04-05 | vs COL | 1 | L 3-5 | 0-1 | 4 | 45,808 | Yovani Gallardo | Ubaldo Jimenez | Ubaldo Jimenez | Yovani Gallardo | Franklin Morales | 3 | 5 | -2 |
| 2010-04-06 | vs COL | 2 | W 7-5 | 1-1 | 3 | 37,344 | Randy Wolf | Greg Smith | Randy Wolf | Greg Smith | Trevor Hoffman | 10 | 10 | 0 |
| 2010-04-07 | vs COL | 3 | W 5-4 | 2-1 | 1 | 35,793 | Doug Davis | Aaron Cook | Todd Coffey | Aaron Cook | Trevor Hoffman | 15 | 14 | 1 |
| 2010-04-09 | vs SLN | 4 | L 4-5 | 2-2 | 3 | 34,018 | David Bush | Kyle Lohse | Dennys Reyes | Trevor Hoffman | Ryan Franklin | 19 | 19 | 0 |
| 2010-04-10 | vs SLN | 5 | L 1-7 | 2-3 | 5 | 42,039 | Yovani Gallardo | Jaime Garcia | Jaime Garcia | Yovani Gallardo | | 20 | 26 | -6 |
| 2010-04-11 | vs SLN | 6 | W 8-7 | 3-3 | 4 | 33,294 | Randy Wolf | Chris Carpenter | Trevor Hoffman | Kyle McClellan | | 28 | 33 | -5 |
| 2010-04-12 | @ CHN | 7 | L 5-9 | 3-4 | 5 | 41,306 | Doug Davis | Ryan Dempster | Ryan Dempster | Doug Davis | | 33 | 42 | -9 |
| 2010-04-14 | @ CHN | 8 | L 6-7 | 3-5 | 5 | 39,565 | David Bush | Randy Wells | Jeff Gray | LaTroy Hawkins | Carlos Marmol | 39 | 49 | -10 |
| 2010-04-15 | @ CHN | 9 | W 8-6 | 4-5 | 5 | 38,026 | Jeff Suppan | Carlos Zambrano | Chris Narveson | Jeff Samardzija | Trevor Hoffman | 47 | 55 | -8 |
| 2010-04-16 | @ WAS | 10 | L 3-5 | 4-6 | 5 | 17,234 | Yovani Gallardo | John Lannan | Brian Bruney | LaTroy Hawkins | Matt Capps | 50 | 60 | -10 |
| 2010-04-17 | @ WAS | 11 | L 0-8 | 4-7 | 5 | 18,673 | Randy Wolf | Livan Hernandez | Livan Hernandez | Randy Wolf | | 50 | 68 | -18 |
| 2010-04-18 | @ WAS | 12 | W 11-7 | 4-8 | 6 | 18,789 | Doug Davis | Jason Marquis | Claudio Vargas | Jason Marquis | | 61 | 75 | -14 |
| 2010-04-20 | @ PIT | 13 | W 8-1 | 5-8 | 6 | 9,386 | David Bush | Charlie Morton | David Bush | Charlie Morton | | 69 | 76 | -7 |
| 2010-04-21 | @ PIT | 14 | W 8-0 | 6-8 | 6 | 12,192 | Yovani Gallardo | Zach Duke | Yovani Gallardo | Zach Duke | | 77 | 76 | 1 |
| 2010-04-22 | @ PIT | 15 | W 20-0 | 7-8 | 4 | 13,634 | Randy Wolf | Daniel McCutchen | Randy Wolf | Daniel McCutchen | | 97 | 76 | 21 |
| 2010-04-23 | vs CHN | 16 | L 1-8 | 7-9 | 6 | 37,848 | Jeff Suppan | Ryan Dempster | Ryan Dempster | Jeff Suppan | | 98 | 84 | 14 |
| 2010-04-24 | vs CHN | 17 | L 1-5 | 7-10 | 6 | 43,410 | Doug Davis | Ted Lilly | Ted Lilly | Doug Davis | | 99 | 89 | 10 |
| 2010-04-25 | vs CHN | 18 | L 2-12 | 8-10 | 6 | 38,634 | David Bush | Randy Wells | Randy Wells | David Bush | | 101 | 101 | 0 |
| 2010-04-26 | vs PIT | 19 | W 17-3 | 8-11 | 6 | 25,892 | Yovani Gallardo | Zach Duke | Yovani Gallardo | Zach Duke | | 118 | 104 | 14 |
| 2010-04-27 | vs PIT | 20 | L 3-7 | 8-12 | 6 | 28,991 | Randy Wolf | Jeff Karstens | Brendan Donnelly | Trevor Hoffman | | 121 | 111 | 10 |
| 2010-04-28 | vs PIT | 21 | L 5-6 | 8-13 | 6 | 28,401 | Chris Narveson | Paul Maholm | D.J. Carrasco | Manny Parra | | 126 | 117 | 9 |
| 2010-04-29 | @ SDN | 22 | L 0-9 | 8-14 | 6 | 16,696 | Doug Davis | Wade LeBlanc | Wade LeBlanc | Doug Davis | | 126 | 126 | 0 |
| 2010-04-30 | @ SDN | 23 | L 0-3 | 8-15 | 6 | 29,366 | David Bush | Clayton Richard | Clayton Richard | David Bush | Heath Bell | 126 | 129 | -3 |
| 2010-05-01 | @ SDN | 24 | W 2-1 | 9-15 | 5 | 25,619 | Yovani Gallardo | Mat Latos | Yovani Gallardo | Mat Latos | Trevor Hoffman | 128 | 130 | -2 |
| 2010-05-02 | @ SDN | 25 | L 0-8 | 9-16 | 5 | 20,074 | Randy Wolf | Jon Garland | Jon Garland | Randy Wolf | | 128 | 138 | -10 |
| 2010-05-04 | @ LAN | 26 | W 11-6 | 9-17 | 5 | 50,714 | Chris Narveson | Clayton Kershaw | Chris Narveson | Clayton Kershaw | | 139 | 144 | -5 |
| 2010-05-05 | @ LAN | 27 | W 11-3 | 9-18 | 6 | 35,659 | Doug Davis | Chad Billingsley | Doug Davis | Chad Billingsley | | 150 | 147 | 3 |
| 2010-05-06 | @ LAN | 28 | L 3-7 | 9-19 | 6 | 38,456 | David Bush | John Ely | Jonathan Broxton | LaTroy Hawkins | | 153 | 154 | -1 |
| 2010-05-07 | @ ARI | 29 | W 3-2 | 10-19 | 5 | 27,067 | Yovani Gallardo | Edwin Jackson | Yovani Gallardo | Edwin Jackson | Trevor Hoffman | 156 | 156 | 0 |
| 2010-05-08 | @ ARI | 30 | W 17-3 | 10-20 | 5 | 26,877 | Randy Wolf | Cesar Valdez | Randy Wolf | Cesar Valdez | | 173 | 159 | 14 |
| 2010-05-09 | @ ARI | 31 | W 6-1 | 11-20 | 5 | 25,358 | Chris Narveson | Ian Kennedy | Chris Narveson | Ian Kennedy | | 179 | 160 | 19 |
| 2010-05-10 | vs ATL | 32 | L 2-8 | 11-21 | 5 | 24,365 | Doug Davis | Tommy Hanson | Tommy Hanson | Doug Davis | | 181 | 168 | 13 |
| 2010-05-11 | vs ATL | 33 | L 3-11 | 12-21 | 5 | 30,678 | David Bush | Tim Hudson | Tim Hudson | David Bush | | 184 | 179 | 5 |
| 2010-05-12 | vs ATL | 34 | L 2-9 | 12-22 | 6 | 30,175 | Yovani Gallardo | Derek Lowe | Derek Lowe | Manny Parra | | 186 | 188 | -2 |
| 2010-05-14 | vs PHI | 35 | L 5-9 | 12-23 | 6 | 41,706 | Randy Wolf | Jamie Moyer | Jamie Moyer | Randy Wolf | | 191 | 197 | -6 |
| 2010-05-15 | vs PHI | 36 | L 6-10 | 13-23 | 6 | 43,069 | Chris Narveson | Joe Blanton | Joe Blanton | Chris Narveson | Jose Contreras | 197 | 207 | -10 |
| 2010-05-16 | vs PHI | 37 | L 2-4 | 13-24 | 6 | 37,023 | David Bush | Cole Hamels | Cole Hamels | David Bush | J.C. Romero | 199 | 211 | -12 |
| 2010-05-17 | @ CIN | 38 | L 3-6 | 13-25 | 6 | 12,409 | Yovani Gallardo | Johnny Cueto | Johnny Cueto | Todd Coffey | Francisco Cordero | 202 | 217 | -15 |
| 2010-05-18 | @ CIN | 39 | L 4-5 | 13-26 | 6 | 17,697 | Manny Parra | Homer Bailey | Carlos Fisher | Trevor Hoffman | | 206 | 222 | -16 |
| 2010-05-19 | @ PIT | 40 | L 4-6 | 13-27 | 6 | 9,526 | Randy Wolf | Brian Burres | Javier Lopez | Randy Wolf | Octavio Dotel | 210 | 228 | -18 |
| 2010-05-20 | @ PIT | 41 | W 4-3 | 14-27 | 6 | 13,975 | Chris Narveson | Paul Maholm | Chris Narveson | Paul Maholm | Carlos Villanueva | 214 | 231 | -17 |
| 2010-05-21 | @ MIN | 42 | L 3-15 | 15-27 | 6 | 38,737 | David Bush | Nick Blackburn | Nick Blackburn | David Bush | | 217 | 246 | -29 |
| 2010-05-22 | @ MIN | 43 | L 7-8 | 15-28 | 6 | 39,152 | Yovani Gallardo | Kevin Slowey | Jesse Crain | Manny Parra | | 224 | 254 | -30 |
| 2010-05-23 | @ MIN | 44 | W 4-3 | 16-28 | 6 | 38,952 | Marco Estrada | Carl Pavano | Manny Parra | Carl Pavano | John Axford | 228 | 257 | -29 |
| 2010-05-25 | vs HOU | 45 | W 6-1 | 17-28 | 5 | 27,363 | Randy Wolf | Felipe Paulino | Randy Wolf | Felipe Paulino | | 234 | 258 | -24 |
| 2010-05-26 | vs HOU | 46 | L 0-5 | 17-29 | 6 | 30,151 | Chris Narveson | Roy Oswalt | Roy Oswalt | Chris Narveson | | 234 | 263 | -29 |
| 2010-05-27 | vs HOU | 47 | W 4-3 | 18-29 | 5 | 34,355 | David Bush | Brett Myers | John Axford | Matt Lindstrom | | 238 | 266 | -28 |
| 2010-05-28 | vs NYN | 48 | W 2-0 | 19-29 | 5 | 32,773 | Yovani Gallardo | Johan Santana | Yovani Gallardo | Ryota Igarashi | | 240 | 266 | -26 |
| 2010-05-29 | vs NYN | 49 | W 8-6 | 20-29 | 5 | 37,841 | Manny Parra | Fernando Nieve | Todd Coffey | Fernando Nieve | John Axford | 248 | 272 | -24 |
| 2010-05-30 | vs NYN | 50 | L 4-10 | 21-29 | 5 | 36,559 | Randy Wolf | R.A. Dickey | R.A. Dickey | Jeff Suppan | | 252 | 282 | -30 |
| 2010-05-31 | @ FLO | 51 | L 5-13 | 22-29 | 5 | 10,115 | Chris Narveson | Nate Robertson | Jorge Sosa | Chris Narveson | | 257 | 295 | -38 |
| 2010-06-01 | @ FLO | 52 | L 4-6 | 22-30 | 6 | 11,202 | David Bush | Ricky Nolasco | Ricky Nolasco | Trevor Hoffman | Leo Nunez | 261 | 301 | -40 |
| 2010-06-02 | @ FLO | 53 | W 7-4 | 23-30 | 6 | 11,468 | Yovani Gallardo | Chris Volstad | Yovani Gallardo | Jorge Sosa | John Axford | 268 | 305 | -37 |
| 2010-06-03 | @ FLO | 54 | L 2-3 | 23-31 | 6 | 11,717 | Chris Capuano | Josh Johnson | Josh Johnson | Chris Capuano | Leo Nunez | 270 | 308 | -38 |
| 2010-06-04 | @ SLN | 55 | L 0-8 | 23-32 | 6 | 43,261 | Randy Wolf | Adam Wainwright | Adam Wainwright | Randy Wolf | | 270 | 316 | -46 |
| 2010-06-05 | @ SLN | 56 | L 4-5 | 23-33 | 6 | 44,180 | Chris Narveson | Adam Ottavino | Mitchell Boggs | John Axford | | 274 | 321 | -47 |
| 2010-06-06 | @ SLN | 57 | W 4-3 | 24-33 | 6 | 40,467 | Manny Parra | Jaime Garcia | Zach Braddock | Jason Motte | John Axford | 278 | 324 | -46 |
| 2010-06-08 | vs CHN | 58 | W 3-2 | 25-33 | 6 | 30,082 | Yovani Gallardo | Ted Lilly | John Axford | Carlos Marmol | | 281 | 326 | -45 |
| 2010-06-09 | vs CHN | 59 | L 4-9 | 25-34 | 6 | 30,326 | Randy Wolf | Carlos Zambrano | Carlos Zambrano | Randy Wolf | | 285 | 335 | -50 |
| 2010-06-10 | vs CHN | 60 | W 5-4 | 26-34 | 6 | 36,363 | David Bush | Ryan Dempster | John Axford | Bob Howry | | 290 | 339 | -49 |
| 2010-06-11 | vs TEX | 61 | W 6-2 | 27-34 | 5 | 33,099 | Chris Narveson | Rich Harden | Chris Narveson | Rich Harden | | 296 | 341 | -45 |
| 2010-06-12 | vs TEX | 62 | L 3-4 | 27-35 | 5 | 39,791 | Manny Parra | Scott Feldman | Scott Feldman | Manny Parra | Chris Ray | 299 | 345 | -46 |
| 2010-06-13 | vs TEX | 63 | L 2-7 | 27-36 | 5 | 36,059 | Yovani Gallardo | Colby Lewis | Colby Lewis | Yovani Gallardo | | 301 | 352 | -51 |
| 2010-06-14 | @ ANA | 64 | W 12-2 | 27-37 | 6 | 39,289 | Randy Wolf | Joe Saunders | Randy Wolf | Joe Saunders | | 313 | 354 | -41 |
| 2010-06-15 | @ ANA | 65 | W 7-1 | 28-37 | 5 | 37,484 | David Bush | Ervin Santana | David Bush | Ervin Santana | | 320 | 355 | -35 |
| 2010-06-16 | @ ANA | 66 | L 1-5 | 28-38 | 5 | 37,416 | Chris Narveson | Joel Pineiro | Joel Pineiro | Chris Narveson | | 321 | 360 | -39 |
| 2010-06-18 | @ COL | 67 | L 0-2 | 28-39 | 5 | 32,340 | Manny Parra | Jason Hammel | Jason Hammel | Manny Parra | Manuel Corpas | 321 | 362 | -41 |
| 2010-06-19 | @ COL | 68 | L 7-8 | 28-40 | 5 | 39,192 | Yovani Gallardo | Jeff Francis | Matt Belisle | Zach Braddock | Rafael Betancourt | 328 | 370 | -42 |
| 2010-06-20 | @ COL | 69 | W 6-1 | 29-40 | 5 | 46,511 | Randy Wolf | Aaron Cook | Trevor Hoffman | Manuel Corpas | | 334 | 371 | -37 |
| 2010-06-22 | vs MIN | 70 | W 7-5 | 30-40 | 5 | 36,995 | Chris Narveson | Scott Baker | Chris Narveson | Scott Baker | John Axford | 341 | 376 | -35 |
| 2010-06-23 | vs MIN | 71 | W 5-3 | 31-40 | 5 | 33,362 | Manny Parra | Francisco Liriano | Manny Parra | Francisco Liriano | John Axford | 346 | 379 | -33 |
| 2010-06-24 | vs MIN | 72 | W 5-0 | 32-40 | 5 | 35,898 | Yovani Gallardo | Nick Blackburn | Yovani Gallardo | Nick Blackburn | | 351 | 379 | -28 |
| 2010-06-25 | vs SEA | 73 | W 8-3 | 33-40 | 5 | 30,087 | David Bush | Ryan Rowland-Smith | David Bush | Ryan Rowland-Smith | | 359 | 382 | -23 |
| 2010-06-26 | vs SEA | 74 | L 4-5 | 33-41 | 5 | 41,655 | Randy Wolf | Doug Fister | Brian Sweeney | Randy Wolf | Brandon League | 363 | 387 | -24 |
| 2010-06-27 | vs SEA | 75 | W 3-0 | 34-41 | 4 | 41,995 | Chris Narveson | Jason Vargas | Chris Narveson | Jason Vargas | John Axford | 366 | 387 | -21 |
| 2010-06-28 | vs HOU | 76 | L 5-9 | 34-42 | 5 | 27,908 | Manny Parra | Bud Norris | Gustavo Chacin | Todd Coffey | | 371 | 396 | -25 |
| 2010-06-29 | vs HOU | 77 | W 7-5 | 35-42 | 4 | 32,907 | Yovani Gallardo | Brett Myers | Yovani Gallardo | Brett Myers | John Axford | 378 | 401 | -23 |
| 2010-06-30 | vs HOU | 78 | L 1-5 | 35-43 | 5 | 30,114 | David Bush | Wandy Rodriguez | Wandy Rodriguez | David Bush | | 379 | 406 | -27 |
| 2010-07-01 | @ SLN | 79 | W 4-1 | 36-43 | 4 | 40,302 | Randy Wolf | Blake Hawksworth | Randy Wolf | Blake Hawksworth | John Axford | 383 | 407 | -24 |
| 2010-07-02 | @ SLN | 80 | L 0-5 | 36-44 | 4 | 43,028 | Chris Narveson | Jaime Garcia | Jaime Garcia | Chris Narveson | | 383 | 412 | -29 |
| 2010-07-03 | @ SLN | 81 | W 12-5 | 36-45 | 5 | 43,276 | Manny Parra | Chris Carpenter | Manny Parra | Chris Carpenter | | 395 | 417 | -22 |
| 2010-07-04 | @ SLN | 82 | L 1-7 | 36-46 | 6 | 38,581 | Yovani Gallardo | Adam Wainwright | Adam Wainwright | Yovani Gallardo | | 396 | 424 | -28 |
| 2010-07-05 | vs SFN | 83 | L 1-6 | 36-47 | 6 | 36,185 | David Bush | Jonathan Sanchez | Jonathan Sanchez | Kameron Loe | | 397 | 430 | -33 |
| 2010-07-06 | vs SFN | 84 | L 1-6 | 36-48 | 6 | 30,896 | Randy Wolf | Madison Bumgarner | Madison Bumgarner | Randy Wolf | | 398 | 436 | -38 |
| 2010-07-07 | vs SFN | 85 | L 2-15 | 37-48 | 6 | 29,387 | Chris Narveson | Tim Lincecum | Tim Lincecum | Chris Narveson | | 400 | 451 | -51 |
| 2010-07-08 | vs SFN | 86 | L 3-9 | 37-49 | 6 | 34,590 | Manny Parra | Barry Zito | Dan Runzler | Manny Parra | | 403 | 460 | -57 |
| 2010-07-09 | vs PIT | 87 | W 5-4 | 38-49 | 5 | 27,767 | Doug Davis | Paul Maholm | John Axford | Evan Meek | | 408 | 464 | -56 |
| 2010-07-10 | vs PIT | 88 | W 4-3 | 39-49 | 5 | 38,588 | David Bush | Jeff Karstens | David Bush | Jeff Karstens | John Axford | 412 | 467 | -55 |
| 2010-07-11 | vs PIT | 89 | W 6-5 | 40-49 | 5 | 34,598 | Randy Wolf | Brad Lincoln | John Axford | Octavio Dotel | | 418 | 472 | -54 |
| 2010-07-15 | @ ATL | 90 | L 1-2 | 40-50 | 5 | 35,057 | David Bush | Jair Jurrjens | Jair Jurrjens | David Bush | Billy Wagner | 419 | 474 | -55 |
| 2010-07-16 | @ ATL | 91 | W 9-3 | 41-50 | 5 | 37,014 | Randy Wolf | Tommy Hanson | Randy Wolf | Tommy Hanson | | 428 | 477 | -49 |
| 2010-07-17 | @ ATL | 92 | W 6-3 | 42-50 | 5 | 48,174 | Chris Narveson | Tim Hudson | Chris Narveson | Tim Hudson | John Axford | 434 | 480 | -46 |
| 2010-07-18 | @ ATL | 93 | L 6-11 | 43-50 | 4 | 24,732 | Manny Parra | Derek Lowe | Derek Lowe | Manny Parra | | 440 | 491 | -51 |
| 2010-07-19 | @ PIT | 94 | W 3-1 | 44-50 | 3 | 12,375 | Chris Capuano | Jeff Karstens | Chris Capuano | Jeff Karstens | John Axford | 443 | 492 | -49 |
| 2010-07-20 | @ PIT | 95 | L 9-11 | 45-50 | 3 | 13,202 | David Bush | Brad Lincoln | D.J. Carrasco | David Bush | Octavio Dotel | 452 | 503 | -51 |
| 2010-07-21 | @ PIT | 96 | L 3-15 | 46-50 | 3 | 13,532 | Randy Wolf | Zach Duke | Zach Duke | Randy Wolf | | 455 | 518 | -63 |
| 2010-07-22 | @ PIT | 97 | W 3-2 | 47-50 | 3 | 18,715 | Yovani Gallardo | Ross Ohlendorf | Yovani Gallardo | Ross Ohlendorf | John Axford | 458 | 520 | -62 |
| 2010-07-23 | vs WAS | 98 | W 7-5 | 48-50 | 3 | 34,822 | Chris Narveson | Craig Stammen | Kameron Loe | Sean Burnett | John Axford | 465 | 525 | -60 |
| 2010-07-24 | vs WAS | 99 | W 4-3 | 49-50 | 3 | 41,987 | Manny Parra | J.D. Martin | John Axford | Drew Storen | | 469 | 528 | -59 |
| 2010-07-25 | vs WAS | 100 | W 8-3 | 50-50 | 3 | 42,414 | David Bush | Ross Detwiler | David Bush | Ross Detwiler | | 477 | 531 | -54 |
| 2010-07-26 | vs CIN | 101 | W 3-2 | 51-50 | 3 | 31,945 | Randy Wolf | Bronson Arroyo | Carlos Villanueva | Bronson Arroyo | John Axford | 480 | 533 | -53 |
| 2010-07-27 | vs CIN | 102 | L 4-12 | 52-50 | 3 | 32,286 | Yovani Gallardo | Edinson Volquez | Logan Ondrusek | Yovani Gallardo | | 484 | 545 | -61 |
| 2010-07-28 | vs CIN | 103 | L 2-10 | 53-50 | 3 | 38,365 | Chris Narveson | Travis Wood | Travis Wood | Chris Narveson | | 486 | 555 | -69 |
| 2010-07-30 | @ HOU | 104 | L 0-5 | 53-51 | 3 | 27,456 | Manny Parra | J.A. Happ | J.A. Happ | Manny Parra | | 486 | 560 | -74 |
| 2010-07-31 | @ HOU | 105 | L 0-6 | 53-52 | 3 | 38,824 | David Bush | Wandy Rodriguez | Wandy Rodriguez | David Bush | | 486 | 566 | -80 |
| 2010-08-01 | @ HOU | 106 | L 2-5 | 53-53 | 3 | 27,964 | Randy Wolf | Wesley Wright | Wesley Wright | Kameron Loe | Brandon Lyon | 488 | 571 | -83 |
| 2010-08-02 | @ CHN | 107 | W 18-1 | 54-53 | 3 | 37,731 | Yovani Gallardo | Randy Wells | Yovani Gallardo | Randy Wells | | 506 | 572 | -66 |
| 2010-08-03 | @ CHN | 108 | W 4-3 | 55-53 | 3 | 36,183 | Chris Narveson | Thomas Diamond | Chris Narveson | Thomas Diamond | John Axford | 510 | 575 | -65 |
| 2010-08-04 | @ CHN | 109 | L 3-15 | 56-53 | 3 | 38,425 | Manny Parra | Ryan Dempster | Ryan Dempster | Manny Parra | | 513 | 590 | -77 |
| 2010-08-06 | vs HOU | 110 | W 6-5 | 57-53 | 3 | 33,952 | David Bush | Wandy Rodriguez | Kameron Loe | Matt Lindstrom | | 519 | 595 | -76 |
| 2010-08-07 | vs HOU | 111 | W 5-2 | 58-53 | 3 | 39,410 | Randy Wolf | Brett Myers | Randy Wolf | Brett Myers | Trevor Hoffman | 524 | 597 | -73 |
| 2010-08-08 | vs HOU | 112 | W 11-6 | 58-54 | 3 | 39,339 | Yovani Gallardo | Wesley Wright | Yovani Gallardo | Wesley Wright | | 535 | 603 | -68 |
| 2010-08-09 | vs ARI | 113 | L 4-7 | 58-55 | 3 | 29,633 | Chris Narveson | Ian Kennedy | Sam Demel | Trevor Hoffman | Aaron Heilman | 539 | 610 | -71 |
| 2010-08-10 | vs ARI | 114 | L 1-2 | 58-56 | 3 | 35,029 | Manny Parra | Barry Enright | Blaine Boyer | Chris Capuano | Sam Demel | 540 | 612 | -72 |
| 2010-08-11 | vs ARI | 115 | L 2-8 | 58-57 | 3 | 29,611 | David Bush | Daniel Hudson | Daniel Hudson | David Bush | | 542 | 620 | -78 |
| 2010-08-12 | vs ARI | 116 | W 8-4 | 59-57 | 3 | 34,808 | Randy Wolf | Rodrigo Lopez | Randy Wolf | Rodrigo Lopez | John Axford | 550 | 624 | -74 |
| 2010-08-13 | @ COL | 117 | L 4-5 | 59-58 | 3 | 39,142 | Yovani Gallardo | Jorge de la Rosa | Taylor Buchholz | Kameron Loe | Huston Street | 554 | 629 | -75 |
| 2010-08-14 | @ COL | 118 | W 5-4 | 60-58 | 3 | 45,264 | Chris Narveson | Esmil Rogers | John Axford | Huston Street | | 559 | 633 | -74 |
| 2010-08-15 | @ COL | 119 | L 5-6 | 60-59 | 3 | 48,133 | Manny Parra | Ubaldo Jimenez | Rafael Betancourt | Trevor Hoffman | | 564 | 639 | -75 |
| 2010-08-17 | @ SLN | 120 | W 3-2 | 61-59 | 3 | 45,380 | David Bush | Jaime Garcia | David Bush | Jaime Garcia | John Axford | 567 | 641 | -74 |
| 2010-08-18 | @ SLN | 121 | W 3-2 | 62-59 | 3 | 41,400 | Randy Wolf | Adam Wainwright | Randy Wolf | Adam Wainwright | Trevor Hoffman | 570 | 643 | -73 |
| 2010-08-20 | vs SDN | 122 | W 10-6 | 62-60 | 3 | 27,976 | Yovani Gallardo | Wade LeBlanc | Chris Capuano | Wade LeBlanc | | 580 | 649 | -69 |
| 2010-08-21 | vs SDN | 123 | W 6-5 | 63-60 | 3 | 40,056 | Chris Narveson | Kevin Correia | Mike McClendon | Kevin Correia | John Axford | 586 | 654 | -68 |
| 2010-08-22 | vs SDN | 124 | L 3-7 | 63-61 | 3 | 32,126 | Manny Parra | Jon Garland | Jon Garland | Manny Parra | | 589 | 661 | -72 |
| 2010-08-24 | vs LAN | 125 | L 3-5 | 63-62 | 3 | 39,055 | David Bush | Ted Lilly | Ted Lilly | David Bush | Hong-Chih Kuo | 592 | 666 | -74 |
| 2010-08-25 | vs LAN | 126 | L 4-5 | 63-63 | 3 | 30,545 | Randy Wolf | Hiroki Kuroda | Hiroki Kuroda | Randy Wolf | Octavio Dotel | 596 | 671 | -75 |
| 2010-08-26 | vs LAN | 127 | L 1-7 | 63-64 | 4 | 32,333 | Yovani Gallardo | Carlos Monasterios | Ronald Belisario | Yovani Gallardo | | 597 | 678 | -81 |
| 2010-08-27 | vs PIT | 128 | W 7-2 | 64-64 | 3 | 32,130 | Chris Narveson | James McDonald | Chris Narveson | James McDonald | | 604 | 680 | -76 |
| 2010-08-28 | vs PIT | 129 | W 8-7 | 65-64 | 3 | 37,782 | Chris Capuano | Zach Duke | Kameron Loe | Wil Ledezma | | 612 | 687 | -75 |
| 2010-08-29 | vs PIT | 130 | W 8-4 | 66-64 | 3 | 35,733 | David Bush | Charlie Morton | David Bush | Charlie Morton | Trevor Hoffman | 620 | 691 | -71 |
| 2010-08-30 | @ CIN | 131 | L 4-5 | 66-65 | 3 | 14,589 | Randy Wolf | Homer Bailey | Francisco Cordero | Trevor Hoffman | | 624 | 696 | -72 |
| 2010-08-31 | @ CIN | 132 | L 4-8 | 66-66 | 4 | 19,218 | Yovani Gallardo | Aaron Harang | Sam LeCure | Yovani Gallardo | | 628 | 704 | -76 |
| 2010-09-01 | @ CIN | 133 | L 1-6 | 66-67 | 4 | 16,412 | Chris Narveson | Johnny Cueto | Aroldis Chapman | Todd Coffey | | 629 | 710 | -81 |
| 2010-09-03 | @ PHI | 134 | L 0-1 | 66-68 | 4 | 44,570 | Chris Capuano | Cole Hamels | Cole Hamels | Chris Capuano | Ryan Madson | 629 | 711 | -82 |
| 2010-09-04 | @ PHI | 135 | L 4-5 | 66-69 | 4 | 45,393 | David Bush | Roy Halladay | Roy Halladay | Kameron Loe | Brad Lidge | 633 | 716 | -83 |
| 2010-09-05 | @ PHI | 136 | W 6-2 | 67-69 | 4 | 45,006 | Randy Wolf | Kyle Kendrick | Randy Wolf | Kyle Kendrick | John Axford | 639 | 718 | -79 |
| 2010-09-06 | vs SLN | 137 | L 6-8 | 67-70 | 4 | 35,190 | Yovani Gallardo | Jake Westbrook | Mitchell Boggs | Zach Braddock | | 645 | 726 | -81 |
| 2010-09-07 | vs SLN | 138 | W 4-2 | 68-70 | 4 | 33,149 | Chris Narveson | Kyle Lohse | Chris Narveson | Kyle Lohse | Trevor Hoffman | 649 | 728 | -79 |
| 2010-09-08 | vs SLN | 139 | W 8-1 | 69-70 | 4 | 34,298 | Chris Capuano | Jaime Garcia | Chris Capuano | Jaime Garcia | | 657 | 729 | -72 |
| 2010-09-10 | vs CHN | 140 | L 0-4 | 69-71 | 4 | 30,975 | David Bush | Carlos Zambrano | Carlos Zambrano | David Bush | Carlos Marmol | 657 | 733 | -76 |
| 2010-09-11 | vs CHN | 141 | L 0-1 | 69-72 | 4 | 41,463 | Randy Wolf | Ryan Dempster | Ryan Dempster | Randy Wolf | Carlos Marmol | 657 | 734 | -77 |
| 2010-09-12 | vs CHN | 142 | W 2-0 | 70-72 | 4 | 37,317 | Yovani Gallardo | Casey Coleman | Yovani Gallardo | Casey Coleman | John Axford | 659 | 734 | -75 |
| 2010-09-13 | @ HOU | 143 | L 2-4 | 70-73 | 4 | 31,342 | Chris Narveson | Brett Myers | Brett Myers | Brandon Kintzler | Matt Lindstrom | 661 | 738 | -77 |
| 2010-09-14 | @ HOU | 144 | L 2-3 | 70-74 | 4 | 33,878 | Chris Capuano | Bud Norris | Bud Norris | Chris Capuano | Brandon Lyon | 663 | 741 | -78 |
| 2010-09-15 | @ HOU | 145 | W 8-6 | 71-74 | 4 | 30,791 | David Bush | J.A. Happ | John Axford | Matt Lindstrom | | 671 | 747 | -76 |
| 2010-09-17 | @ SFN | 146 | W 3-0 | 72-74 | 4 | 41,835 | Randy Wolf | Madison Bumgarner | Randy Wolf | Madison Bumgarner | | 674 | 747 | -73 |
| 2010-09-18 | @ SFN | 147 | W 2-1 | 73-74 | 4 | 41,767 | Yovani Gallardo | Tim Lincecum | Yovani Gallardo | Tim Lincecum | John Axford | 676 | 748 | -72 |
| 2010-09-19 | @ SFN | 148 | L 2-9 | 73-75 | 4 | 41,113 | Chris Narveson | Barry Zito | Barry Zito | Chris Narveson | | 678 | 757 | -79 |
| 2010-09-20 | vs CIN | 149 | L 2-5 | 73-76 | 4 | 30,024 | Chris Capuano | Homer Bailey | Nick Masset | Kameron Loe | Francisco Cordero | 680 | 762 | -82 |
| 2010-09-21 | vs CIN | 150 | L 3-4 | 73-77 | 4 | 22,761 | David Bush | Edinson Volquez | Edinson Volquez | David Bush | Francisco Cordero | 683 | 766 | -83 |
| 2010-09-22 | vs CIN | 151 | W 13-1 | 74-77 | 4 | 27,004 | Randy Wolf | Johnny Cueto | Randy Wolf | Johnny Cueto | | 696 | 767 | -71 |
| 2010-09-23 | vs FLO | 152 | W 8-3 | 75-77 | 4 | 31,212 | Yovani Gallardo | Anibal Sanchez | Yovani Gallardo | Anibal Sanchez | | 704 | 770 | -66 |
| 2010-09-24 | vs FLO | 153 | W 6-2 | 76-77 | 4 | 32,235 | Mark Rogers | Andrew Miller | Jeremy Jeffress | Andrew Miller | | 710 | 772 | -62 |
| 2010-09-25 | vs FLO | 154 | L 0-4 | 76-78 | 4 | 34,325 | Chris Narveson | Chris Volstad | Chris Volstad | Chris Narveson | | 710 | 776 | -66 |
| 2010-09-26 | vs FLO | 155 | W 7-1 | 77-78 | 4 | 29,059 | Chris Capuano | Adalberto Mendez | Chris Capuano | Adalberto Mendez | | 717 | 777 | -60 |
| 2010-09-28 | @ NYN | 156 | L 3-4 | 77-79 | 4 | 24,666 | Randy Wolf | Mike Pelfrey | Elmer Dessens | John Axford | | 720 | 781 | -61 |
| 2010-09-29 | @ NYN | 157 | W 8-7 | 78-79 | 5 | 0 | Yovani Gallardo | Jonathon Niese | Carlos Villanueva | Manny Acosta | John Axford | 728 | 788 | -60 |
| 2010-09-29 | @ NYN | 158 | W 3-1 | 78-79 | 5 | 28,280 | David Bush | R.A. Dickey | David Bush | R.A. Dickey | Trevor Hoffman | 731 | 789 | -58 |
| 2010-09-30 | @ NYN | 159 | W 9-2 | 80-79 | 3 | 24,661 | Chris Narveson | Dillon Gee | Chris Narveson | Dillon Gee | | 740 | 791 | -51 |
| 2010-10-01 | @ CIN | 160 | W 4-3 | 81-79 | 3 | 28,844 | Mark Rogers | Travis Wood | Mike McClendon | Sam LeCure | John Axford | 744 | 794 | -50 |
| 2010-10-02 | @ CIN | 161 | L 4-7 | 81-80 | 3 | 28,173 | Chris Capuano | Homer Bailey | Logan Ondrusek | Todd Coffey | Francisco Cordero | 748 | 801 | -53 |
| 2010-10-03 | @ CIN | 162 | L 2-3 | 81-81 | 3 | 37,582 | Randy Wolf | Aaron Harang | Matt Maloney | Randy Wolf | Francisco Cordero | 750 | 804 | -54 |