| 2010-04-05 | @ PIT | 1 | L 5-11 | 1-0 | 3 | 39,024 | Vicente Padilla | Zach Duke | Zach Duke | Vicente Padilla | | 5 | 11 | -6 |
| 2010-04-07 | @ PIT | 2 | L 3-4 | 1-1 | 3 | 31,061 | Clayton Kershaw | Ross Ohlendorf | Brendan Donnelly | Ramon Ortiz | | 8 | 15 | -7 |
| 2010-04-08 | @ PIT | 3 | W 10-2 | 1-2 | 3 | 9,352 | Chad Billingsley | Paul Maholm | Chad Billingsley | Paul Maholm | | 18 | 17 | 1 |
| 2010-04-09 | @ FLO | 4 | W 7-3 | 2-2 | 4 | 40,666 | Hiroki Kuroda | Chris Volstad | Hiroki Kuroda | Chris Volstad | | 25 | 20 | 5 |
| 2010-04-10 | @ FLO | 5 | L 6-7 | 2-3 | 4 | 25,308 | Vicente Padilla | Josh Johnson | Jose Veras | George Sherrill | | 31 | 27 | 4 |
| 2010-04-11 | @ FLO | 6 | L 5-6 | 2-4 | 4 | 18,758 | Charlie Haeger | Anibal Sanchez | Clay Hensley | Jeff Weaver | Leo Nunez | 36 | 33 | 3 |
| 2010-04-13 | vs ARI | 7 | W 9-5 | 3-4 | 4 | 56,000 | Clayton Kershaw | Ian Kennedy | Clayton Kershaw | Ian Kennedy | | 45 | 38 | 7 |
| 2010-04-14 | vs ARI | 8 | L 7-9 | 3-5 | 4 | 44,621 | Chad Billingsley | Rodrigo Lopez | Leo Rosales | Russ Ortiz | | 52 | 47 | 5 |
| 2010-04-15 | vs ARI | 9 | W 6-5 | 4-5 | 4 | 39,697 | Hiroki Kuroda | Dan Haren | Jonathan Broxton | Blaine Boyer | | 58 | 52 | 6 |
| 2010-04-16 | vs SFN | 10 | W 10-8 | 4-6 | 4 | 49,319 | Vicente Padilla | Todd Wellemeyer | Vicente Padilla | Todd Wellemeyer | | 68 | 60 | 8 |
| 2010-04-17 | vs SFN | 11 | L 0-9 | 4-7 | 4 | 44,734 | Charlie Haeger | Tim Lincecum | Tim Lincecum | Charlie Haeger | | 68 | 69 | -1 |
| 2010-04-18 | vs SFN | 12 | W 2-1 | 5-7 | 3 | 50,433 | Clayton Kershaw | Barry Zito | Ramon Troncoso | Sergio Romo | Jonathan Broxton | 70 | 70 | 0 |
| 2010-04-20 | @ CIN | 13 | L 9-11 | 6-7 | 3 | 12,965 | Chad Billingsley | Homer Bailey | Mike Lincoln | Ramon Troncoso | Francisco Cordero | 79 | 81 | -2 |
| 2010-04-21 | @ CIN | 14 | W 14-6 | 6-8 | 3 | 12,203 | Hiroki Kuroda | Aaron Harang | Hiroki Kuroda | Aaron Harang | | 93 | 87 | 6 |
| 2010-04-22 | @ CIN | 15 | L 5-8 | 6-9 | 3 | 13,261 | Vicente Padilla | Mike Leake | Mike Leake | Hong-Chih Kuo | Francisco Cordero | 98 | 95 | 3 |
| 2010-04-23 | @ WAS | 16 | L 1-5 | 6-10 | 4 | 23,859 | Charlie Haeger | Luis Atilano | Luis Atilano | Charlie Haeger | | 99 | 100 | -1 |
| 2010-04-24 | @ WAS | 17 | W 4-3 | 7-10 | 3 | 18,039 | Clayton Kershaw | Craig Stammen | Carlos Monasterios | Miguel Batista | | 103 | 103 | 0 |
| 2010-04-25 | @ WAS | 18 | L 0-1 | 7-11 | 5 | 18,395 | Chad Billingsley | Scott Olsen | Scott Olsen | Chad Billingsley | Matt Capps | 103 | 104 | -1 |
| 2010-04-27 | @ NYN | 19 | L 0-4 | 7-12 | 6 | 0 | Hiroki Kuroda | Johan Santana | Johan Santana | Hiroki Kuroda | | 103 | 108 | -5 |
| 2010-04-27 | @ NYN | 20 | L 5-10 | 7-12 | 6 | 32,012 | Charlie Haeger | Oliver Perez | Hisanori Takahashi | Charlie Haeger | | 108 | 118 | -10 |
| 2010-04-28 | @ NYN | 21 | L 3-7 | 8-13 | 5 | 29,724 | John Ely | John Maine | John Maine | John Ely | | 111 | 125 | -14 |
| 2010-04-29 | vs PIT | 22 | L 0-2 | 8-14 | 5 | 40,185 | Clayton Kershaw | Brian Burres | Brian Burres | Clayton Kershaw | Evan Meek | 111 | 127 | -16 |
| 2010-04-30 | vs PIT | 23 | W 6-2 | 9-14 | 5 | 46,775 | Chad Billingsley | Charlie Morton | Chad Billingsley | Charlie Morton | | 117 | 129 | -12 |
| 2010-05-01 | vs PIT | 24 | W 5-1 | 10-14 | 4 | 40,483 | Carlos Monasterios | Zach Duke | Ramon Ortiz | Zach Duke | | 122 | 130 | -8 |
| 2010-05-02 | vs PIT | 25 | W 9-3 | 11-14 | 4 | 39,339 | Hiroki Kuroda | Jeff Karstens | Hiroki Kuroda | Jeff Karstens | | 131 | 133 | -2 |
| 2010-05-04 | vs MIL | 26 | L 6-11 | 12-14 | 4 | 50,714 | Clayton Kershaw | Chris Narveson | Chris Narveson | Clayton Kershaw | | 137 | 144 | -7 |
| 2010-05-05 | vs MIL | 27 | L 3-11 | 13-14 | 3 | 35,659 | Chad Billingsley | Doug Davis | Doug Davis | Chad Billingsley | | 140 | 155 | -15 |
| 2010-05-06 | vs MIL | 28 | W 7-3 | 14-14 | 3 | 38,456 | John Ely | David Bush | Jonathan Broxton | LaTroy Hawkins | | 147 | 158 | -11 |
| 2010-05-07 | vs COL | 29 | W 6-5 | 15-14 | 3 | 40,567 | Hiroki Kuroda | Esmil Rogers | Jeff Weaver | Matt Daley | Jonathan Broxton | 153 | 163 | -10 |
| 2010-05-08 | vs COL | 30 | L 0-8 | 15-15 | 3 | 42,287 | Charlie Haeger | Jhoulis Chacin | Jhoulis Chacin | Charlie Haeger | | 153 | 171 | -18 |
| 2010-05-09 | vs COL | 31 | W 2-0 | 16-15 | 3 | 40,718 | Clayton Kershaw | Ubaldo Jimenez | Clayton Kershaw | Ubaldo Jimenez | Jonathan Broxton | 155 | 171 | -16 |
| 2010-05-10 | @ ARI | 32 | W 7-3 | 17-15 | 3 | 19,863 | Chad Billingsley | Rodrigo Lopez | Chad Billingsley | Rodrigo Lopez | | 162 | 174 | -12 |
| 2010-05-11 | @ ARI | 33 | W 13-3 | 17-16 | 3 | 21,030 | John Ely | Dan Haren | John Ely | Dan Haren | | 175 | 177 | -2 |
| 2010-05-12 | @ ARI | 34 | W 6-3 | 18-16 | 3 | 22,714 | Hiroki Kuroda | Edwin Jackson | Hiroki Kuroda | Edwin Jackson | Jonathan Broxton | 181 | 180 | 1 |
| 2010-05-14 | @ SDN | 35 | W 4-3 | 19-16 | 3 | 42,056 | Ramon Ortiz | Jon Garland | Jeff Weaver | Luke Gregerson | Jonathan Broxton | 185 | 183 | 2 |
| 2010-05-15 | @ SDN | 36 | W 4-1 | 20-16 | 2 | 42,436 | Clayton Kershaw | Kevin Correia | Clayton Kershaw | Kevin Correia | Jonathan Broxton | 189 | 184 | 5 |
| 2010-05-16 | @ SDN | 37 | W 1-0 | 21-16 | 2 | 42,327 | Chad Billingsley | Wade LeBlanc | Chad Billingsley | Wade LeBlanc | Jonathan Broxton | 190 | 184 | 6 |
| 2010-05-17 | vs HOU | 38 | W 6-2 | 22-16 | 1 | 35,282 | John Ely | Wandy Rodriguez | John Ely | Wandy Rodriguez | | 196 | 186 | 10 |
| 2010-05-18 | vs HOU | 39 | W 7-3 | 23-16 | 1 | 55,662 | Hiroki Kuroda | Bud Norris | Hiroki Kuroda | Bud Norris | | 203 | 189 | 14 |
| 2010-05-19 | vs SDN | 40 | L 5-10 | 24-16 | 1 | 40,138 | Ramon Ortiz | Jon Garland | Jon Garland | Ramon Ortiz | | 208 | 199 | 9 |
| 2010-05-20 | vs SDN | 41 | W 4-1 | 25-16 | 1 | 38,856 | Clayton Kershaw | Kevin Correia | Clayton Kershaw | Kevin Correia | Jonathan Broxton | 212 | 200 | 12 |
| 2010-05-21 | vs DET | 42 | W 4-1 | 26-16 | 1 | 44,282 | Chad Billingsley | Dontrelle Willis | Chad Billingsley | Dontrelle Willis | Jonathan Broxton | 216 | 201 | 15 |
| 2010-05-22 | vs DET | 43 | W 6-4 | 27-16 | 1 | 45,117 | John Ely | Armando Galarraga | John Ely | Armando Galarraga | Jonathan Broxton | 222 | 205 | 17 |
| 2010-05-23 | vs DET | 44 | L 2-6 | 27-17 | 1 | 46,053 | Hiroki Kuroda | Rick Porcello | Rick Porcello | Hiroki Kuroda | | 224 | 211 | 13 |
| 2010-05-25 | @ CHN | 45 | L 0-3 | 27-18 | 1 | 34,749 | Clayton Kershaw | Ryan Dempster | Ryan Dempster | Clayton Kershaw | Carlos Marmol | 224 | 214 | 10 |
| 2010-05-26 | @ CHN | 46 | W 8-5 | 28-18 | 1 | 35,828 | Chad Billingsley | Tom Gorzelanny | Chad Billingsley | Tom Gorzelanny | Jonathan Broxton | 232 | 219 | 13 |
| 2010-05-27 | @ CHN | 47 | L 0-1 | 28-19 | 1 | 33,868 | John Ely | Ted Lilly | Sean Marshall | John Ely | Carlos Marmol | 232 | 220 | 12 |
| 2010-05-28 | @ COL | 48 | W 5-4 | 29-19 | 1 | 40,162 | Carlos Monasterios | Jeff Francis | Carlos Monasterios | Jeff Francis | Jonathan Broxton | 237 | 224 | 13 |
| 2010-05-29 | @ COL | 49 | L 3-11 | 30-19 | 1 | 43,261 | Hiroki Kuroda | Aaron Cook | Aaron Cook | Hiroki Kuroda | | 240 | 235 | 5 |
| 2010-05-30 | @ COL | 50 | W 4-3 | 31-19 | 1 | 48,682 | Clayton Kershaw | Jhoulis Chacin | Clayton Kershaw | Jhoulis Chacin | Jonathan Broxton | 244 | 238 | 6 |
| 2010-05-31 | vs ARI | 51 | W 5-4 | 32-19 | 1 | 45,325 | Chad Billingsley | Rodrigo Lopez | Jonathan Broxton | Esmerling Vasquez | | 249 | 242 | 7 |
| 2010-06-01 | vs ARI | 52 | W 1-0 | 33-19 | 1 | 36,533 | John Ely | Dan Haren | Jeff Weaver | Juan Gutierrez | | 250 | 242 | 8 |
| 2010-06-02 | vs ARI | 53 | W 1-0 | 34-19 | 1 | 35,355 | Carlos Monasterios | Edwin Jackson | Travis Schlichting | Cesar Valdez | | 251 | 242 | 9 |
| 2010-06-03 | vs ATL | 54 | L 3-4 | 34-20 | 1 | 35,333 | Hiroki Kuroda | Kris Medlen | Kris Medlen | Hiroki Kuroda | Jonny Venters | 254 | 246 | 8 |
| 2010-06-04 | vs ATL | 55 | W 5-4 | 35-20 | 1 | 42,459 | Clayton Kershaw | Kenshin Kawakami | Hong-Chih Kuo | Kenshin Kawakami | Jonathan Broxton | 259 | 250 | 9 |
| 2010-06-05 | vs ATL | 56 | L 3-9 | 35-21 | 1 | 48,207 | Chad Billingsley | Tommy Hanson | Tommy Hanson | Chad Billingsley | | 262 | 259 | 3 |
| 2010-06-06 | vs ATL | 57 | W 5-4 | 36-21 | 1 | 37,944 | John Ely | Tim Hudson | Ronald Belisario | Jesse Chavez | | 267 | 263 | 4 |
| 2010-06-07 | vs SLN | 58 | W 12-4 | 36-22 | 1 | 44,876 | Carlos Monasterios | Blake Hawksworth | Carlos Monasterios | Blake Hawksworth | | 279 | 267 | 12 |
| 2010-06-08 | vs SLN | 59 | W 1-0 | 37-22 | 1 | 48,046 | Hiroki Kuroda | Chris Carpenter | Hong-Chih Kuo | Trever Miller | Jonathan Broxton | 280 | 267 | 13 |
| 2010-06-09 | vs SLN | 60 | W 4-3 | 38-22 | 1 | 43,299 | Clayton Kershaw | Adam Wainwright | Clayton Kershaw | Adam Wainwright | Jonathan Broxton | 284 | 270 | 14 |
| 2010-06-11 | vs ANA | 61 | L 1-10 | 38-23 | 1 | 52,407 | Chad Billingsley | Joel Pineiro | Joel Pineiro | Chad Billingsley | | 285 | 280 | 5 |
| 2010-06-12 | vs ANA | 62 | L 2-4 | 38-24 | 1 | 52,806 | John Ely | Scott Kazmir | Scott Kazmir | John Ely | Brian Fuentes | 287 | 284 | 3 |
| 2010-06-13 | vs ANA | 63 | L 5-6 | 38-25 | 1 | 52,776 | Carlos Monasterios | Jered Weaver | Jered Weaver | Carlos Monasterios | Brian Fuentes | 292 | 290 | 2 |
| 2010-06-15 | @ CIN | 64 | W 12-0 | 39-25 | 1 | 22,639 | Hiroki Kuroda | Aaron Harang | Hiroki Kuroda | Aaron Harang | | 304 | 290 | 14 |
| 2010-06-16 | @ CIN | 65 | W 6-2 | 40-25 | 1 | 23,083 | Clayton Kershaw | Mike Leake | Clayton Kershaw | Mike Leake | Hong-Chih Kuo | 310 | 292 | 18 |
| 2010-06-17 | @ CIN | 66 | L 1-7 | 40-26 | 1 | 25,585 | John Ely | Bronson Arroyo | Bronson Arroyo | John Ely | | 311 | 299 | 12 |
| 2010-06-18 | @ BOS | 67 | L 6-10 | 41-26 | 1 | 37,723 | Carlos Monasterios | Felix Doubront | Felix Doubront | Carlos Monasterios | Daniel Bard | 317 | 309 | 8 |
| 2010-06-19 | @ BOS | 68 | L 4-5 | 41-27 | 1 | 37,454 | Vicente Padilla | Tim Wakefield | Jonathan Papelbon | Ronald Belisario | | 321 | 314 | 7 |
| 2010-06-20 | @ BOS | 69 | L 0-2 | 41-28 | 1 | 37,430 | Hiroki Kuroda | Clay Buchholz | Clay Buchholz | Hiroki Kuroda | Jonathan Papelbon | 321 | 316 | 5 |
| 2010-06-22 | @ ANA | 70 | L 3-6 | 41-29 | 1 | 41,595 | Clayton Kershaw | Ervin Santana | Ervin Santana | Clayton Kershaw | Brian Fuentes | 324 | 322 | 2 |
| 2010-06-23 | @ ANA | 71 | L 1-2 | 41-30 | 1 | 41,001 | John Ely | Joel Pineiro | Joel Pineiro | John Ely | Brian Fuentes | 325 | 324 | 1 |
| 2010-06-24 | @ ANA | 72 | W 10-6 | 41-31 | 1 | 44,043 | Charlie Haeger | Scott Kazmir | Jeff Weaver | Scott Kazmir | | 335 | 330 | 5 |
| 2010-06-25 | vs NYA | 73 | L 1-2 | 41-32 | 1 | 56,000 | Vicente Padilla | CC Sabathia | CC Sabathia | Vicente Padilla | Mariano Rivera | 336 | 332 | 4 |
| 2010-06-26 | vs NYA | 74 | W 9-4 | 42-32 | 1 | 56,000 | Hiroki Kuroda | A.J. Burnett | Hiroki Kuroda | A.J. Burnett | | 345 | 336 | 9 |
| 2010-06-27 | vs NYA | 75 | L 6-8 | 42-33 | 1 | 56,000 | Clayton Kershaw | Andy Pettitte | Mariano Rivera | Ramon Troncoso | | 351 | 344 | 7 |
| 2010-06-28 | @ SFN | 76 | W 4-2 | 43-33 | 1 | 34,626 | Chad Billingsley | Barry Zito | Jeff Weaver | Santiago Casilla | Hong-Chih Kuo | 355 | 346 | 9 |
| 2010-06-29 | @ SFN | 77 | W 4-2 | 44-33 | 1 | 35,289 | John Ely | Matt Cain | John Ely | Matt Cain | Ronald Belisario | 359 | 348 | 11 |
| 2010-06-30 | @ SFN | 78 | W 8-2 | 45-33 | 1 | 39,962 | Vicente Padilla | Jonathan Sanchez | Vicente Padilla | Jonathan Sanchez | | 367 | 350 | 17 |
| 2010-07-02 | @ ARI | 79 | L 5-12 | 46-33 | 1 | 23,155 | Hiroki Kuroda | Edwin Jackson | Edwin Jackson | Hiroki Kuroda | | 372 | 362 | 10 |
| 2010-07-03 | @ ARI | 80 | W 14-1 | 47-33 | 1 | 44,169 | Clayton Kershaw | Rodrigo Lopez | Clayton Kershaw | Rodrigo Lopez | | 386 | 363 | 23 |
| 2010-07-04 | @ ARI | 81 | W 3-1 | 48-33 | 1 | 26,517 | Chad Billingsley | Dan Haren | Hong-Chih Kuo | Aaron Heilman | Jonathan Broxton | 389 | 364 | 25 |
| 2010-07-05 | vs FLO | 82 | L 5-6 | 48-34 | 1 | 47,801 | John Ely | Nate Robertson | Nate Robertson | John Ely | Leo Nunez | 394 | 370 | 24 |
| 2010-07-06 | vs FLO | 83 | W 7-3 | 49-34 | 1 | 41,575 | Vicente Padilla | Chris Volstad | Vicente Padilla | Chris Volstad | Jonathan Broxton | 401 | 373 | 28 |
| 2010-07-07 | vs FLO | 84 | L 0-4 | 49-35 | 1 | 41,947 | Hiroki Kuroda | Josh Johnson | Josh Johnson | Hiroki Kuroda | | 401 | 377 | 24 |
| 2010-07-08 | vs CHN | 85 | W 3-2 | 50-35 | 1 | 43,640 | Clayton Kershaw | Randy Wells | Clayton Kershaw | Randy Wells | Jonathan Broxton | 404 | 379 | 25 |
| 2010-07-09 | vs CHN | 86 | W 9-7 | 51-35 | 1 | 43,790 | Chad Billingsley | Ted Lilly | Chad Billingsley | Ted Lilly | | 413 | 386 | 27 |
| 2010-07-10 | vs CHN | 87 | L 3-7 | 51-36 | 1 | 49,016 | John Ely | Tom Gorzelanny | Tom Gorzelanny | John Ely | | 416 | 393 | 23 |
| 2010-07-11 | vs CHN | 88 | W 7-0 | 52-36 | 1 | 45,398 | Vicente Padilla | Carlos Silva | Vicente Padilla | Carlos Silva | | 423 | 393 | 30 |
| 2010-07-15 | @ SLN | 89 | L 1-7 | 52-37 | 1 | 41,771 | Clayton Kershaw | Chris Carpenter | Chris Carpenter | Clayton Kershaw | | 424 | 400 | 24 |
| 2010-07-16 | @ SLN | 90 | L 4-8 | 52-38 | 1 | 44,074 | Chad Billingsley | Jaime Garcia | Kyle McClellan | Chad Billingsley | | 428 | 408 | 20 |
| 2010-07-17 | @ SLN | 91 | L 0-2 | 52-39 | 1 | 43,667 | Hiroki Kuroda | Adam Wainwright | Adam Wainwright | Hiroki Kuroda | Ryan Franklin | 428 | 410 | 18 |
| 2010-07-18 | @ SLN | 92 | L 4-5 | 52-40 | 2 | 40,743 | Vicente Padilla | Jeff Suppan | Ryan Franklin | Jonathan Broxton | | 432 | 415 | 17 |
| 2010-07-19 | vs SFN | 93 | L 2-5 | 52-41 | 2 | 45,056 | James McDonald | Madison Bumgarner | Madison Bumgarner | James McDonald | Brian Wilson | 434 | 420 | 14 |
| 2010-07-20 | vs SFN | 94 | L 5-7 | 52-42 | 2 | 53,381 | Clayton Kershaw | Tim Lincecum | Santiago Casilla | Jonathan Broxton | Jeremy Affeldt | 439 | 427 | 12 |
| 2010-07-21 | vs SFN | 95 | W 2-0 | 53-42 | 2 | 45,151 | Chad Billingsley | Barry Zito | Chad Billingsley | Barry Zito | | 441 | 427 | 14 |
| 2010-07-22 | vs NYN | 96 | W 2-0 | 54-42 | 2 | 42,299 | Hiroki Kuroda | Hisanori Takahashi | Hiroki Kuroda | Hisanori Takahashi | Hong-Chih Kuo | 443 | 427 | 16 |
| 2010-07-23 | vs NYN | 97 | L 1-6 | 54-43 | 2 | 44,626 | Vicente Padilla | Johan Santana | Johan Santana | Vicente Padilla | | 444 | 433 | 11 |
| 2010-07-24 | vs NYN | 98 | W 3-2 | 55-43 | 2 | 43,506 | Carlos Monasterios | Mike Pelfrey | George Sherrill | Oliver Perez | | 447 | 435 | 12 |
| 2010-07-25 | vs NYN | 99 | W 1-0 | 56-43 | 2 | 39,897 | Clayton Kershaw | R.A. Dickey | Clayton Kershaw | Pedro Feliciano | Kenley Jansen | 448 | 435 | 13 |
| 2010-07-27 | @ SDN | 100 | W 2-0 | 57-43 | 2 | 38,428 | Chad Billingsley | Jon Garland | Chad Billingsley | Jon Garland | Jonathan Broxton | 450 | 435 | 15 |
| 2010-07-28 | @ SDN | 101 | L 1-6 | 57-44 | 2 | 40,188 | Hiroki Kuroda | Clayton Richard | Clayton Richard | Hiroki Kuroda | | 451 | 441 | 10 |
| 2010-07-29 | @ SDN | 102 | L 2-3 | 57-45 | 2 | 42,075 | Vicente Padilla | Mat Latos | Heath Bell | George Sherrill | | 453 | 444 | 9 |
| 2010-07-30 | @ SFN | 103 | L 5-6 | 57-46 | 2 | 42,847 | Carlos Monasterios | Tim Lincecum | Tim Lincecum | Carlos Monasterios | Chris Ray | 458 | 450 | 8 |
| 2010-07-31 | @ SFN | 104 | L 1-2 | 57-47 | 2 | 42,882 | Chad Billingsley | Barry Zito | Guillermo Mota | Jonathan Broxton | | 459 | 452 | 7 |
| 2010-08-01 | @ SFN | 105 | L 0-2 | 57-48 | 2 | 42,922 | Clayton Kershaw | Matt Cain | Matt Cain | Clayton Kershaw | Brian Wilson | 459 | 454 | 5 |
| 2010-08-02 | vs SDN | 106 | L 5-10 | 58-48 | 2 | 40,860 | Hiroki Kuroda | Clayton Richard | Clayton Richard | Hiroki Kuroda | | 464 | 464 | 0 |
| 2010-08-03 | vs SDN | 107 | W 2-1 | 59-48 | 2 | 38,886 | Ted Lilly | Mat Latos | Ted Lilly | Mat Latos | Jonathan Broxton | 466 | 465 | 1 |
| 2010-08-04 | vs SDN | 108 | W 9-0 | 60-48 | 2 | 48,988 | Vicente Padilla | Wade LeBlanc | Vicente Padilla | Wade LeBlanc | | 475 | 465 | 10 |
| 2010-08-05 | vs SDN | 109 | L 0-5 | 60-49 | 2 | 44,739 | Chad Billingsley | Kevin Correia | Kevin Correia | Chad Billingsley | Heath Bell | 475 | 470 | 5 |
| 2010-08-06 | vs WAS | 110 | L 3-6 | 60-50 | 2 | 39,153 | Clayton Kershaw | John Lannan | John Lannan | Clayton Kershaw | Drew Storen | 478 | 476 | 2 |
| 2010-08-07 | vs WAS | 111 | W 3-2 | 61-50 | 2 | 44,896 | Hiroki Kuroda | Livan Hernandez | Jonathan Broxton | Sean Burnett | | 481 | 478 | 3 |
| 2010-08-08 | vs WAS | 112 | W 8-3 | 62-50 | 2 | 43,639 | Ted Lilly | Jason Marquis | Ted Lilly | Jason Marquis | | 489 | 481 | 8 |
| 2010-08-10 | @ PHI | 113 | W 15-9 | 62-51 | 2 | 44,881 | Vicente Padilla | Kyle Kendrick | Vicente Padilla | Kyle Kendrick | | 504 | 490 | 14 |
| 2010-08-11 | @ PHI | 114 | L 0-2 | 62-52 | 2 | 45,144 | Chad Billingsley | Roy Oswalt | Roy Oswalt | Chad Billingsley | Brad Lidge | 504 | 492 | 12 |
| 2010-08-12 | @ PHI | 115 | L 9-10 | 63-52 | 2 | 44,819 | Clayton Kershaw | Joe Blanton | Danys Baez | Jonathan Broxton | | 513 | 502 | 11 |
| 2010-08-13 | @ ATL | 116 | L 0-1 | 63-53 | 2 | 38,602 | Hiroki Kuroda | Tim Hudson | Tim Hudson | Hiroki Kuroda | Billy Wagner | 513 | 503 | 10 |
| 2010-08-14 | @ ATL | 117 | W 2-1 | 64-53 | 2 | 49,267 | Ted Lilly | Derek Lowe | Ted Lilly | Derek Lowe | Hong-Chih Kuo | 515 | 504 | 11 |
| 2010-08-15 | @ ATL | 118 | L 1-13 | 64-54 | 2 | 28,105 | Vicente Padilla | Jair Jurrjens | Jair Jurrjens | Vicente Padilla | | 516 | 517 | -1 |
| 2010-08-16 | @ ATL | 119 | L 3-4 | 64-55 | 2 | 20,414 | Chad Billingsley | Tommy Hanson | Peter Moylan | Hong-Chih Kuo | | 519 | 521 | -2 |
| 2010-08-17 | vs COL | 120 | W 6-0 | 65-55 | 2 | 49,540 | Clayton Kershaw | Jhoulis Chacin | Clayton Kershaw | Jhoulis Chacin | | 525 | 521 | 4 |
| 2010-08-18 | vs COL | 121 | L 2-3 | 65-56 | 2 | 44,268 | Hiroki Kuroda | Jason Hammel | Rafael Betancourt | Octavio Dotel | Huston Street | 527 | 524 | 3 |
| 2010-08-19 | vs COL | 122 | W 2-0 | 66-56 | 2 | 45,104 | Ted Lilly | Jorge de la Rosa | Ted Lilly | Jorge de la Rosa | | 529 | 524 | 5 |
| 2010-08-20 | vs CIN | 123 | L 1-3 | 66-57 | 2 | 46,418 | Carlos Monasterios | Homer Bailey | Homer Bailey | Carlos Monasterios | Francisco Cordero | 530 | 527 | 3 |
| 2010-08-21 | vs CIN | 124 | W 8-5 | 67-57 | 2 | 49,435 | Chad Billingsley | Johnny Cueto | Chad Billingsley | Johnny Cueto | Jonathan Broxton | 538 | 532 | 6 |
| 2010-08-22 | vs CIN | 125 | L 2-5 | 67-58 | 2 | 44,788 | Clayton Kershaw | Bronson Arroyo | Bronson Arroyo | Clayton Kershaw | Francisco Cordero | 540 | 537 | 3 |
| 2010-08-24 | @ MIL | 126 | W 5-3 | 68-58 | 2 | 39,055 | Ted Lilly | David Bush | Ted Lilly | David Bush | Hong-Chih Kuo | 545 | 540 | 5 |
| 2010-08-25 | @ MIL | 127 | W 5-4 | 69-58 | 2 | 30,545 | Hiroki Kuroda | Randy Wolf | Hiroki Kuroda | Randy Wolf | Octavio Dotel | 550 | 544 | 6 |
| 2010-08-26 | @ MIL | 128 | W 7-1 | 70-58 | 2 | 32,333 | Carlos Monasterios | Yovani Gallardo | Ronald Belisario | Yovani Gallardo | | 557 | 545 | 12 |
| 2010-08-27 | @ COL | 129 | W 6-2 | 71-58 | 2 | 41,964 | Clayton Kershaw | Ubaldo Jimenez | Jonathan Broxton | Ubaldo Jimenez | Hong-Chih Kuo | 563 | 547 | 16 |
| 2010-08-28 | @ COL | 130 | L 3-5 | 71-59 | 2 | 45,322 | Chad Billingsley | Jhoulis Chacin | Jhoulis Chacin | Chad Billingsley | | 566 | 552 | 14 |
| 2010-08-29 | @ COL | 131 | L 5-10 | 72-59 | 2 | 38,343 | Ted Lilly | Jason Hammel | Jason Hammel | Ted Lilly | | 571 | 562 | 9 |
| 2010-08-30 | vs PHI | 132 | W 3-0 | 73-59 | 2 | 44,896 | Hiroki Kuroda | Roy Halladay | Hiroki Kuroda | Roy Halladay | Hong-Chih Kuo | 574 | 562 | 12 |
| 2010-08-31 | vs PHI | 133 | L 4-8 | 73-60 | 2 | 45,164 | Carlos Monasterios | Kyle Kendrick | Kyle Kendrick | Carlos Monasterios | | 578 | 570 | 8 |
| 2010-09-01 | vs PHI | 134 | L 1-5 | 73-61 | 2 | 37,080 | Clayton Kershaw | Roy Oswalt | Roy Oswalt | Clayton Kershaw | | 579 | 575 | 4 |
| 2010-09-03 | vs SFN | 135 | W 4-2 | 74-61 | 2 | 43,046 | Chad Billingsley | Barry Zito | Chad Billingsley | Barry Zito | Hong-Chih Kuo | 583 | 577 | 6 |
| 2010-09-04 | vs SFN | 136 | L 4-5 | 74-62 | 2 | 48,220 | Ted Lilly | Matt Cain | Javier Lopez | Jonathan Broxton | Brian Wilson | 587 | 582 | 5 |
| 2010-09-05 | vs SFN | 137 | L 0-3 | 74-63 | 2 | 43,758 | Hiroki Kuroda | Jonathan Sanchez | Jonathan Sanchez | Hiroki Kuroda | Brian Wilson | 587 | 585 | 2 |
| 2010-09-06 | @ SDN | 138 | L 2-4 | 74-64 | 2 | 23,574 | Vicente Padilla | Tim Stauffer | Mike Adams | Vicente Padilla | Heath Bell | 589 | 589 | 0 |
| 2010-09-07 | @ SDN | 139 | L 1-2 | 74-65 | 2 | 20,071 | Clayton Kershaw | Mat Latos | Mat Latos | Clayton Kershaw | Heath Bell | 590 | 591 | -1 |
| 2010-09-08 | @ SDN | 140 | L 0-4 | 74-66 | 2 | 20,851 | Chad Billingsley | Cory Luebke | Cory Luebke | Chad Billingsley | Luke Gregerson | 590 | 595 | -5 |
| 2010-09-09 | @ HOU | 141 | L 2-3 | 74-67 | 2 | 28,081 | Ted Lilly | Bud Norris | Bud Norris | Ted Lilly | Brandon Lyon | 592 | 598 | -6 |
| 2010-09-10 | @ HOU | 142 | W 4-2 | 75-67 | 2 | 31,010 | Hiroki Kuroda | J.A. Happ | Octavio Dotel | Fernando Abad | | 596 | 600 | -4 |
| 2010-09-11 | @ HOU | 143 | W 6-3 | 76-67 | 2 | 39,237 | John Ely | Wandy Rodriguez | Kenley Jansen | Brandon Lyon | Hong-Chih Kuo | 602 | 603 | -1 |
| 2010-09-12 | @ HOU | 144 | L 4-7 | 76-68 | 2 | 30,240 | Carlos Monasterios | Nelson Figueroa | Gustavo Chacin | Ramon Troncoso | Brandon Lyon | 606 | 610 | -4 |
| 2010-09-14 | @ SFN | 145 | W 1-0 | 77-68 | 2 | 36,076 | Clayton Kershaw | Barry Zito | Clayton Kershaw | Barry Zito | | 607 | 610 | -3 |
| 2010-09-15 | @ SFN | 146 | L 1-2 | 77-69 | 2 | 34,685 | Chad Billingsley | Matt Cain | Matt Cain | Chad Billingsley | Brian Wilson | 608 | 612 | -4 |
| 2010-09-16 | @ SFN | 147 | L 2-10 | 78-69 | 2 | 38,434 | Ted Lilly | Jonathan Sanchez | Jonathan Sanchez | Ted Lilly | | 610 | 622 | -12 |
| 2010-09-17 | vs COL | 148 | L 5-7 | 78-70 | 2 | 38,449 | Hiroki Kuroda | Ubaldo Jimenez | Ubaldo Jimenez | Hiroki Kuroda | Huston Street | 615 | 629 | -14 |
| 2010-09-18 | vs COL | 149 | L 2-12 | 79-70 | 2 | 40,191 | John Ely | Jhoulis Chacin | Jhoulis Chacin | John Ely | | 617 | 641 | -24 |
| 2010-09-19 | vs COL | 150 | W 7-6 | 80-70 | 2 | 37,402 | Clayton Kershaw | Jason Hammel | George Sherrill | Manny Delcarmen | | 624 | 647 | -23 |
| 2010-09-21 | vs SDN | 151 | L 0-6 | 80-71 | 2 | 44,166 | Chad Billingsley | Clayton Richard | Clayton Richard | Chad Billingsley | | 624 | 653 | -29 |
| 2010-09-22 | vs SDN | 152 | L 1-3 | 80-72 | 2 | 33,728 | Ted Lilly | Tim Stauffer | Tim Stauffer | Ted Lilly | Heath Bell | 625 | 656 | -31 |
| 2010-09-23 | vs SDN | 153 | W 3-1 | 81-72 | 2 | 33,040 | Hiroki Kuroda | Mat Latos | Hiroki Kuroda | Mat Latos | Hong-Chih Kuo | 628 | 657 | -29 |
| 2010-09-24 | @ ARI | 154 | W 3-1 | 82-72 | 2 | 38,516 | Clayton Kershaw | Barry Enright | Clayton Kershaw | Barry Enright | Kenley Jansen | 631 | 658 | -27 |
| 2010-09-25 | @ ARI | 155 | L 2-5 | 82-73 | 2 | 41,477 | John Ely | Daniel Hudson | Daniel Hudson | John Ely | Juan Gutierrez | 633 | 663 | -30 |
| 2010-09-26 | @ ARI | 156 | L 4-5 | 82-74 | 2 | 37,911 | Chad Billingsley | Joe Saunders | Sam Demel | Jonathan Broxton | Juan Gutierrez | 637 | 668 | -31 |
| 2010-09-27 | @ COL | 157 | W 3-1 | 83-74 | 2 | 32,085 | Ted Lilly | Ubaldo Jimenez | Ted Lilly | Ubaldo Jimenez | Hong-Chih Kuo | 640 | 669 | -29 |
| 2010-09-28 | @ COL | 158 | W 9-7 | 84-74 | 2 | 34,430 | Hiroki Kuroda | Jeff Francis | Ronald Belisario | Octavio Dotel | Kenley Jansen | 649 | 676 | -27 |
| 2010-09-29 | @ COL | 159 | W 7-6 | 85-74 | 2 | 33,296 | Carlos Monasterios | Jhoulis Chacin | Ramon Troncoso | Jhoulis Chacin | Ronald Belisario | 656 | 682 | -26 |
| 2010-10-01 | vs ARI | 160 | L 5-7 | 85-75 | 2 | 36,713 | John Ely | Zach Kroenke | Zach Kroenke | John Ely | Juan Gutierrez | 661 | 689 | -28 |
| 2010-10-02 | vs ARI | 161 | W 3-2 | 86-75 | 2 | 41,918 | Chad Billingsley | Joe Saunders | Chad Billingsley | Joe Saunders | Kenley Jansen | 664 | 691 | -27 |
| 2010-10-03 | vs ARI | 162 | W 3-1 | 87-75 | 2 | 38,007 | Ted Lilly | Rodrigo Lopez | Ted Lilly | Rodrigo Lopez | Hong-Chih Kuo | 667 | 692 | -25 |