| 2010-04-05 | vs SFN | 1 | L 2-5 | - | | 43,836 | Roy Oswalt | Tim Lincecum | Tim Lincecum | Roy Oswalt | Brian Wilson | 2 | 5 | -3 |
| 2010-04-06 | vs SFN | 2 | L 0-3 | - | | 24,237 | Wandy Rodriguez | Barry Zito | Barry Zito | Wandy Rodriguez | Brian Wilson | 2 | 8 | -6 |
| 2010-04-07 | vs SFN | 3 | L 4-10 | - | | 21,599 | Brett Myers | Matt Cain | Jeremy Affeldt | Samuel Gervacio | | 6 | 18 | -12 |
| 2010-04-09 | vs PHI | 4 | L 0-8 | - | | 27,288 | Bud Norris | J.A. Happ | J.A. Happ | Bud Norris | | 6 | 26 | -20 |
| 2010-04-10 | vs PHI | 5 | L 6-9 | - | | 35,138 | Felipe Paulino | Jamie Moyer | Jamie Moyer | Brandon Lyon | | 12 | 35 | -23 |
| 2010-04-11 | vs PHI | 6 | L 1-2 | - | | 28,619 | Roy Oswalt | Roy Halladay | Roy Halladay | Roy Oswalt | | 13 | 37 | -24 |
| 2010-04-12 | @ SLN | 7 | L 0-5 | - | | 46,918 | Wandy Rodriguez | Adam Wainwright | Adam Wainwright | Wandy Rodriguez | | 13 | 42 | -29 |
| 2010-04-14 | @ SLN | 8 | L 1-2 | - | | 35,883 | Brett Myers | Brad Penny | Brad Penny | Brett Myers | Ryan Franklin | 14 | 44 | -30 |
| 2010-04-15 | @ SLN | 9 | W 5-1 | - | | 35,371 | Bud Norris | Kyle Lohse | Bud Norris | Kyle Lohse | | 19 | 45 | -26 |
| 2010-04-16 | @ CHN | 10 | L 2-7 | - | | 37,291 | Felipe Paulino | Carlos Silva | Carlos Silva | Felipe Paulino | | 21 | 52 | -31 |
| 2010-04-17 | @ CHN | 11 | W 4-3 | - | | 40,471 | Roy Oswalt | Tom Gorzelanny | Roy Oswalt | Tom Gorzelanny | Matt Lindstrom | 25 | 55 | -30 |
| 2010-04-18 | @ CHN | 12 | W 3-2 | - | | 39,506 | Wandy Rodriguez | Ryan Dempster | Tim Byrdak | Sean Marshall | Matt Lindstrom | 28 | 57 | -29 |
| 2010-04-20 | vs FLO | 13 | W 7-5 | - | | 24,135 | Brett Myers | Chris Volstad | Brandon Lyon | Tim Wood | Matt Lindstrom | 35 | 62 | -27 |
| 2010-04-21 | vs FLO | 14 | W 5-4 | - | | 22,607 | Bud Norris | Josh Johnson | Wilton Lopez | Burke Badenhop | Matt Lindstrom | 40 | 66 | -26 |
| 2010-04-22 | vs FLO | 15 | L 1-5 | - | | 21,802 | Felipe Paulino | Anibal Sanchez | Anibal Sanchez | Felipe Paulino | | 41 | 71 | -30 |
| 2010-04-23 | vs PIT | 16 | W 4-3 | - | | 30,018 | Roy Oswalt | Paul Maholm | Roy Oswalt | Paul Maholm | Matt Lindstrom | 45 | 74 | -29 |
| 2010-04-24 | vs PIT | 17 | W 5-2 | - | | 30,562 | Wandy Rodriguez | Chris Jakubauskas | Wandy Rodriguez | Chris Jakubauskas | Matt Lindstrom | 50 | 76 | -26 |
| 2010-04-25 | vs PIT | 18 | W 10-3 | - | | 27,210 | Brett Myers | Charlie Morton | Brett Myers | Charlie Morton | | 60 | 79 | -19 |
| 2010-04-27 | vs CIN | 19 | L 2-6 | - | | 22,467 | Bud Norris | Aaron Harang | Aaron Harang | Bud Norris | | 62 | 85 | -23 |
| 2010-04-28 | vs CIN | 20 | L 4-6 | - | | 21,035 | Felipe Paulino | Mike Leake | Mike Leake | Felipe Paulino | | 66 | 91 | -25 |
| 2010-04-29 | vs CIN | 21 | L 2-4 | - | | 21,493 | Roy Oswalt | Bronson Arroyo | Bronson Arroyo | Roy Oswalt | Francisco Cordero | 68 | 95 | -27 |
| 2010-04-30 | @ ATL | 22 | L 2-4 | - | | 30,082 | Brett Myers | Tommy Hanson | Tommy Hanson | Brett Myers | Billy Wagner | 70 | 99 | -29 |
| 2010-05-01 | @ ATL | 23 | L 1-10 | - | | 27,035 | Wandy Rodriguez | Tim Hudson | Tim Hudson | Wandy Rodriguez | | 71 | 109 | -38 |
| 2010-05-02 | @ ATL | 24 | L 1-7 | - | | 25,665 | Bud Norris | Derek Lowe | Derek Lowe | Bud Norris | | 72 | 116 | -44 |
| 2010-05-03 | vs ARI | 25 | L 1-9 | - | | 20,370 | Felipe Paulino | Cesar Valdez | Cesar Valdez | Felipe Paulino | | 73 | 125 | -52 |
| 2010-05-04 | vs ARI | 26 | L 0-1 | - | | 22,661 | Roy Oswalt | Ian Kennedy | Ian Kennedy | Roy Oswalt | Chad Qualls | 73 | 126 | -53 |
| 2010-05-05 | vs ARI | 27 | W 4-2 | - | | 21,030 | Brett Myers | Rodrigo Lopez | Matt Lindstrom | Juan Gutierrez | | 77 | 128 | -51 |
| 2010-05-06 | vs ARI | 28 | L 3-6 | - | | 21,019 | Wandy Rodriguez | Dan Haren | Dan Haren | Wandy Rodriguez | | 80 | 134 | -54 |
| 2010-05-07 | vs SDN | 29 | L 0-7 | - | | 25,586 | Bud Norris | Mat Latos | Mat Latos | Bud Norris | | 80 | 141 | -61 |
| 2010-05-08 | vs SDN | 30 | L 1-2 | - | | 27,038 | Felipe Paulino | Jon Garland | Jon Garland | Felipe Paulino | Heath Bell | 81 | 143 | -62 |
| 2010-05-09 | vs SDN | 31 | W 4-3 | - | | 23,526 | Roy Oswalt | Tim Stauffer | Brandon Lyon | Ryan Webb | | 85 | 146 | -61 |
| 2010-05-11 | @ SLN | 32 | W 6-3 | - | | 35,875 | Brett Myers | Brad Penny | Brett Myers | Brad Penny | Matt Lindstrom | 91 | 149 | -58 |
| 2010-05-12 | @ SLN | 33 | W 9-6 | - | | 36,342 | Wandy Rodriguez | Kyle Lohse | Wandy Rodriguez | Kyle Lohse | Matt Lindstrom | 100 | 155 | -55 |
| 2010-05-13 | @ SLN | 34 | W 4-1 | - | | 39,026 | Bud Norris | Chris Carpenter | Bud Norris | Chris Carpenter | Matt Lindstrom | 104 | 156 | -52 |
| 2010-05-14 | @ SFN | 35 | L 2-8 | - | | 38,650 | Felipe Paulino | Todd Wellemeyer | Todd Wellemeyer | Felipe Paulino | | 106 | 164 | -58 |
| 2010-05-15 | @ SFN | 36 | L 1-2 | - | | 40,060 | Roy Oswalt | Tim Lincecum | Tim Lincecum | Roy Oswalt | Brian Wilson | 107 | 166 | -59 |
| 2010-05-16 | @ SFN | 37 | L 3-4 | - | | 40,582 | Brett Myers | Barry Zito | Barry Zito | Brett Myers | Brian Wilson | 110 | 170 | -60 |
| 2010-05-17 | @ LAN | 38 | L 2-6 | - | | 35,282 | Wandy Rodriguez | John Ely | John Ely | Wandy Rodriguez | | 112 | 176 | -64 |
| 2010-05-18 | @ LAN | 39 | L 3-7 | - | | 55,662 | Bud Norris | Hiroki Kuroda | Hiroki Kuroda | Bud Norris | | 115 | 183 | -68 |
| 2010-05-19 | vs COL | 40 | W 7-3 | - | | 25,200 | Felipe Paulino | Greg Smith | Brandon Lyon | Esmil Rogers | | 122 | 186 | -64 |
| 2010-05-20 | vs COL | 41 | L 0-4 | - | | 25,932 | Roy Oswalt | Ubaldo Jimenez | Ubaldo Jimenez | Roy Oswalt | | 122 | 190 | -68 |
| 2010-05-21 | vs TBA | 42 | W 2-1 | - | | 27,601 | Brett Myers | Matt Garza | Brett Myers | Matt Garza | Matt Lindstrom | 124 | 191 | -67 |
| 2010-05-22 | vs TBA | 43 | L 2-4 | - | | 33,778 | Wandy Rodriguez | Jeff Niemann | Jeff Niemann | Wandy Rodriguez | Rafael Soriano | 126 | 195 | -69 |
| 2010-05-23 | vs TBA | 44 | L 6-10 | - | | 28,801 | Bud Norris | David Price | David Price | Brian Moehler | Rafael Soriano | 132 | 205 | -73 |
| 2010-05-25 | @ MIL | 45 | L 1-6 | - | | 27,363 | Felipe Paulino | Randy Wolf | Randy Wolf | Felipe Paulino | | 133 | 211 | -78 |
| 2010-05-26 | @ MIL | 46 | W 5-0 | - | | 30,151 | Roy Oswalt | Chris Narveson | Roy Oswalt | Chris Narveson | | 138 | 211 | -73 |
| 2010-05-27 | @ MIL | 47 | L 3-4 | - | | 34,355 | Brett Myers | David Bush | John Axford | Matt Lindstrom | | 141 | 215 | -74 |
| 2010-05-28 | @ CIN | 48 | L 6-15 | - | | 30,813 | Wandy Rodriguez | Sam LeCure | Sam LeCure | Wandy Rodriguez | | 147 | 230 | -83 |
| 2010-05-29 | @ CIN | 49 | L 2-12 | - | | 36,918 | Brian Moehler | Aaron Harang | Aaron Harang | Brian Moehler | | 149 | 242 | -93 |
| 2010-05-30 | @ CIN | 50 | W 2-0 | - | | 36,038 | Felipe Paulino | Mike Leake | Brandon Lyon | Micah Owings | Matt Lindstrom | 151 | 242 | -91 |
| 2010-05-31 | vs WAS | 51 | L 4-14 | - | | 34,704 | Roy Oswalt | Luis Atilano | Luis Atilano | Roy Oswalt | | 155 | 256 | -101 |
| 2010-06-01 | vs WAS | 52 | W 8-7 | - | | 25,249 | Brett Myers | Craig Stammen | Wilton Lopez | Matt Capps | | 163 | 263 | -100 |
| 2010-06-02 | vs WAS | 53 | W 5-1 | - | | 26,736 | Wandy Rodriguez | John Lannan | Wandy Rodriguez | John Lannan | | 168 | 264 | -96 |
| 2010-06-03 | vs WAS | 54 | W 6-4 | - | | 21,814 | Brian Moehler | J.D. Martin | Matt Lindstrom | Matt Capps | | 174 | 268 | -94 |
| 2010-06-04 | vs CHN | 55 | W 3-1 | - | | 28,784 | Felipe Paulino | Carlos Zambrano | Felipe Paulino | Carlos Zambrano | Matt Lindstrom | 177 | 269 | -92 |
| 2010-06-05 | vs CHN | 56 | L 5-8 | - | | 34,241 | Roy Oswalt | Ryan Dempster | Ryan Dempster | Roy Oswalt | Carlos Marmol | 182 | 277 | -95 |
| 2010-06-06 | vs CHN | 57 | W 6-3 | - | | 29,493 | Brett Myers | Randy Wells | Brett Myers | Randy Wells | Matt Lindstrom | 188 | 280 | -92 |
| 2010-06-07 | @ COL | 58 | L 1-5 | - | | 28,251 | Wandy Rodriguez | Jason Hammel | Jason Hammel | Wandy Rodriguez | Manuel Corpas | 189 | 285 | -96 |
| 2010-06-08 | @ COL | 59 | W 4-3 | - | | 26,201 | Brian Moehler | Jeff Francis | Wilton Lopez | Matt Belisle | Matt Lindstrom | 193 | 288 | -95 |
| 2010-06-09 | @ COL | 60 | W 6-2 | - | | 27,114 | Felipe Paulino | Aaron Cook | Brandon Lyon | Matt Belisle | | 199 | 290 | -91 |
| 2010-06-10 | @ COL | 61 | W 5-4 | - | | 28,329 | Roy Oswalt | Jhoulis Chacin | Roy Oswalt | Jhoulis Chacin | Brandon Lyon | 204 | 294 | -90 |
| 2010-06-11 | @ NYA | 62 | L 3-4 | - | | 46,883 | Brett Myers | Andy Pettitte | Andy Pettitte | Brett Myers | Mariano Rivera | 207 | 298 | -91 |
| 2010-06-12 | @ NYA | 63 | L 3-9 | - | | 46,159 | Wandy Rodriguez | Javier Vazquez | Javier Vazquez | Wandy Rodriguez | | 210 | 307 | -97 |
| 2010-06-13 | @ NYA | 64 | L 5-9 | - | | 46,832 | Brian Moehler | Phil Hughes | Phil Hughes | Brian Moehler | | 215 | 316 | -101 |
| 2010-06-15 | @ KCA | 65 | L 7-15 | - | | 24,862 | Felipe Paulino | Kyle Davies | Kanekoa Texeira | Felipe Paulino | | 222 | 331 | -109 |
| 2010-06-16 | @ KCA | 66 | W 4-2 | - | | 17,675 | Roy Oswalt | Bruce Chen | Roy Oswalt | Bruce Chen | Matt Lindstrom | 226 | 333 | -107 |
| 2010-06-17 | @ KCA | 67 | L 2-5 | - | | 16,255 | Brett Myers | Anthony Lerew | Victor Marte | Brett Myers | Joakim Soria | 228 | 338 | -110 |
| 2010-06-18 | vs TEX | 68 | L 3-9 | - | | 33,951 | Wandy Rodriguez | Scott Feldman | Scott Feldman | Wandy Rodriguez | | 231 | 347 | -116 |
| 2010-06-19 | vs TEX | 69 | L 1-5 | - | | 41,060 | Brian Moehler | Colby Lewis | Colby Lewis | Brian Moehler | | 232 | 352 | -120 |
| 2010-06-20 | vs TEX | 70 | L 4-5 | - | | 33,753 | Felipe Paulino | C.J. Wilson | Chris Ray | Casey Daigle | Neftali Feliz | 236 | 357 | -121 |
| 2010-06-22 | vs SFN | 71 | L 1-3 | - | | 29,777 | Roy Oswalt | Tim Lincecum | Tim Lincecum | Roy Oswalt | Brian Wilson | 237 | 360 | -123 |
| 2010-06-23 | vs SFN | 72 | W 6-3 | - | | 29,311 | Brett Myers | Barry Zito | Brett Myers | Barry Zito | Matt Lindstrom | 243 | 363 | -120 |
| 2010-06-24 | vs SFN | 73 | W 7-5 | - | | 26,662 | Wandy Rodriguez | Matt Cain | Wandy Rodriguez | Matt Cain | Matt Lindstrom | 250 | 368 | -118 |
| 2010-06-25 | @ TEX | 74 | W 7-4 | - | | 43,457 | Brian Moehler | Colby Lewis | Brian Moehler | Colby Lewis | Matt Lindstrom | 257 | 372 | -115 |
| 2010-06-26 | @ TEX | 75 | L 2-7 | - | | 28,951 | Josh Banks | C.J. Wilson | C.J. Wilson | Josh Banks | | 259 | 379 | -120 |
| 2010-06-27 | @ TEX | 76 | L 1-10 | - | | 37,487 | Roy Oswalt | Tommy Hunter | Tommy Hunter | Roy Oswalt | | 260 | 389 | -129 |
| 2010-06-28 | @ MIL | 77 | W 9-5 | - | | 27,908 | Bud Norris | Manny Parra | Gustavo Chacin | Todd Coffey | | 269 | 394 | -125 |
| 2010-06-29 | @ MIL | 78 | L 5-7 | - | | 32,907 | Brett Myers | Yovani Gallardo | Yovani Gallardo | Brett Myers | John Axford | 274 | 401 | -127 |
| 2010-06-30 | @ MIL | 79 | W 5-1 | - | | 30,114 | Wandy Rodriguez | David Bush | Wandy Rodriguez | David Bush | | 279 | 402 | -123 |
| 2010-07-01 | @ SDN | 80 | W 6-3 | - | | 18,618 | Brian Moehler | Jon Garland | Chris Sampson | Luke Gregerson | Matt Lindstrom | 285 | 405 | -120 |
| 2010-07-02 | @ SDN | 81 | L 0-3 | - | | 30,691 | Roy Oswalt | Mat Latos | Mat Latos | Brandon Lyon | Heath Bell | 285 | 408 | -123 |
| 2010-07-03 | @ SDN | 82 | L 0-1 | - | | 40,042 | Bud Norris | Kevin Correia | Mike Adams | Gustavo Chacin | Heath Bell | 285 | 409 | -124 |
| 2010-07-04 | @ SDN | 83 | L 2-3 | - | | 23,498 | Brett Myers | Wade LeBlanc | Heath Bell | Brandon Lyon | | 287 | 412 | -125 |
| 2010-07-06 | vs PIT | 84 | W 6-2 | - | | 23,210 | Wandy Rodriguez | Brad Lincoln | Wandy Rodriguez | Brad Lincoln | | 293 | 414 | -121 |
| 2010-07-07 | vs PIT | 85 | W 6-3 | - | | 23,123 | Brian Moehler | Daniel McCutchen | Casey Daigle | Daniel McCutchen | Matt Lindstrom | 299 | 417 | -118 |
| 2010-07-08 | vs PIT | 86 | W 2-0 | - | | 24,416 | Roy Oswalt | Ross Ohlendorf | Roy Oswalt | Ross Ohlendorf | | 301 | 417 | -116 |
| 2010-07-09 | vs SLN | 87 | L 0-8 | - | | 33,224 | Bud Norris | Adam Wainwright | Adam Wainwright | Bud Norris | | 301 | 425 | -124 |
| 2010-07-10 | vs SLN | 88 | W 4-1 | - | | 37,518 | Brett Myers | Jeff Suppan | Brett Myers | Jeff Suppan | Matt Lindstrom | 305 | 426 | -121 |
| 2010-07-11 | vs SLN | 89 | L 2-4 | - | | 32,975 | Wandy Rodriguez | Blake Hawksworth | Blake Hawksworth | Wandy Rodriguez | Ryan Franklin | 307 | 430 | -123 |
| 2010-07-16 | @ PIT | 90 | W 5-2 | - | | 23,273 | Brett Myers | Zach Duke | Brett Myers | Zach Duke | Matt Lindstrom | 312 | 432 | -120 |
| 2010-07-17 | @ PIT | 91 | L 6-12 | - | | 36,665 | Bud Norris | Ross Ohlendorf | Javier Lopez | Bud Norris | | 318 | 444 | -126 |
| 2010-07-18 | @ PIT | 92 | L 0-9 | - | | 16,638 | Roy Oswalt | Paul Maholm | Paul Maholm | Roy Oswalt | | 318 | 453 | -135 |
| 2010-07-19 | @ CHN | 93 | W 11-5 | - | | 35,514 | Wandy Rodriguez | Carlos Silva | Wandy Rodriguez | Carlos Silva | | 329 | 458 | -129 |
| 2010-07-20 | @ CHN | 94 | L 7-14 | - | | 36,401 | Wesley Wright | Ryan Dempster | Andrew Cashner | Brandon Lyon | | 336 | 472 | -136 |
| 2010-07-21 | @ CHN | 95 | W 4-3 | - | | 38,533 | Brett Myers | Ted Lilly | Brandon Lyon | Bob Howry | Gustavo Chacin | 340 | 475 | -135 |
| 2010-07-23 | vs CIN | 96 | L 4-6 | - | | 30,575 | Bud Norris | Travis Wood | Logan Ondrusek | Tim Byrdak | Francisco Cordero | 344 | 481 | -137 |
| 2010-07-24 | vs CIN | 97 | L 0-7 | - | | 31,552 | Roy Oswalt | Johnny Cueto | Johnny Cueto | Roy Oswalt | | 344 | 488 | -144 |
| 2010-07-25 | vs CIN | 98 | W 4-0 | - | | 25,705 | Wandy Rodriguez | Mike Leake | Wandy Rodriguez | Mike Leake | | 348 | 488 | -140 |
| 2010-07-26 | vs CHN | 99 | L 2-5 | - | | 25,037 | Wesley Wright | Carlos Silva | Carlos Silva | Wesley Wright | Carlos Marmol | 350 | 493 | -143 |
| 2010-07-27 | vs CHN | 100 | W 6-1 | - | | 28,047 | Brett Myers | Ted Lilly | Brett Myers | Andrew Cashner | | 356 | 494 | -138 |
| 2010-07-28 | vs CHN | 101 | W 8-1 | - | | 28,046 | Bud Norris | Randy Wells | Bud Norris | Randy Wells | | 364 | 495 | -131 |
| 2010-07-30 | vs MIL | 102 | W 5-0 | - | | 27,456 | J.A. Happ | Manny Parra | J.A. Happ | Manny Parra | | 369 | 495 | -126 |
| 2010-07-31 | vs MIL | 103 | W 6-0 | - | | 38,824 | Wandy Rodriguez | David Bush | Wandy Rodriguez | David Bush | | 375 | 495 | -120 |
| 2010-08-01 | vs MIL | 104 | W 5-2 | - | | 27,964 | Wesley Wright | Randy Wolf | Wesley Wright | Kameron Loe | Brandon Lyon | 380 | 497 | -117 |
| 2010-08-02 | @ SLN | 105 | W 9-4 | - | | 43,369 | Brett Myers | Jake Westbrook | Nelson Figueroa | Mike MacDougal | | 389 | 501 | -112 |
| 2010-08-03 | @ SLN | 106 | W 18-4 | - | | 41,958 | Bud Norris | Jaime Garcia | Bud Norris | Jaime Garcia | | 407 | 505 | -98 |
| 2010-08-04 | @ SLN | 107 | L 4-8 | - | | 41,596 | J.A. Happ | Chris Carpenter | Chris Carpenter | J.A. Happ | | 411 | 513 | -102 |
| 2010-08-06 | @ MIL | 108 | L 5-6 | - | | 33,952 | Wandy Rodriguez | David Bush | Kameron Loe | Matt Lindstrom | | 416 | 519 | -103 |
| 2010-08-07 | @ MIL | 109 | L 2-5 | - | | 39,410 | Brett Myers | Randy Wolf | Randy Wolf | Brett Myers | Trevor Hoffman | 418 | 524 | -106 |
| 2010-08-08 | @ MIL | 110 | L 6-11 | - | | 39,339 | Wesley Wright | Yovani Gallardo | Yovani Gallardo | Wesley Wright | | 424 | 535 | -111 |
| 2010-08-09 | vs ATL | 111 | W 10-4 | - | | 34,684 | Bud Norris | Mike Minor | Tim Byrdak | Kyle Farnsworth | | 434 | 539 | -105 |
| 2010-08-10 | vs ATL | 112 | L 2-4 | - | | 34,155 | J.A. Happ | Jair Jurrjens | Jonny Venters | Matt Lindstrom | Billy Wagner | 436 | 543 | -107 |
| 2010-08-11 | vs ATL | 113 | L 2-8 | - | | 31,352 | Wandy Rodriguez | Tommy Hanson | Billy Wagner | Brandon Lyon | | 438 | 551 | -113 |
| 2010-08-13 | vs PIT | 114 | W 4-1 | - | | 36,124 | Brett Myers | Ross Ohlendorf | Wilton Lopez | Evan Meek | Brandon Lyon | 442 | 552 | -110 |
| 2010-08-14 | vs PIT | 115 | W 3-2 | - | | 31,608 | Bud Norris | Paul Maholm | Bud Norris | Paul Maholm | Brandon Lyon | 445 | 554 | -109 |
| 2010-08-15 | vs PIT | 116 | W 8-2 | - | | 34,372 | J.A. Happ | Jeff Karstens | J.A. Happ | Jeff Karstens | | 453 | 556 | -103 |
| 2010-08-16 | vs NYN | 117 | L 1-3 | - | | 22,688 | Wandy Rodriguez | Jonathon Niese | Pedro Feliciano | Matt Lindstrom | Hisanori Takahashi | 454 | 559 | -105 |
| 2010-08-17 | vs NYN | 118 | W 4-3 | - | | 26,279 | Nelson Figueroa | Johan Santana | Mark Melancon | Johan Santana | Wilton Lopez | 458 | 562 | -104 |
| 2010-08-18 | vs NYN | 119 | L 2-3 | - | | 23,403 | Brett Myers | R.A. Dickey | Elmer Dessens | Gustavo Chacin | Manny Acosta | 460 | 565 | -105 |
| 2010-08-19 | vs NYN | 120 | W 3-2 | - | | 26,271 | Bud Norris | Pat Misch | Bud Norris | Pat Misch | Brandon Lyon | 463 | 567 | -104 |
| 2010-08-20 | @ FLO | 121 | L 0-9 | - | | 19,456 | J.A. Happ | Anibal Sanchez | Anibal Sanchez | J.A. Happ | | 463 | 576 | -113 |
| 2010-08-21 | @ FLO | 122 | L 3-6 | - | | 21,721 | Wandy Rodriguez | Chris Volstad | Chris Volstad | Wandy Rodriguez | | 466 | 582 | -116 |
| 2010-08-22 | @ FLO | 123 | W 2-1 | - | | 18,886 | Nelson Figueroa | Andrew Miller | Wilton Lopez | Jose Veras | Brandon Lyon | 468 | 583 | -115 |
| 2010-08-23 | @ PHI | 124 | W 3-2 | - | | 44,081 | Brett Myers | Joe Blanton | Brett Myers | Ryan Madson | Brandon Lyon | 471 | 585 | -114 |
| 2010-08-24 | @ PHI | 125 | W 4-2 | - | | 45,494 | Bud Norris | Cole Hamels | Jeff Fulchino | David Herndon | | 475 | 587 | -112 |
| 2010-08-25 | @ PHI | 126 | W 3-2 | - | | 44,657 | J.A. Happ | Roy Halladay | J.A. Happ | Roy Halladay | Brandon Lyon | 478 | 589 | -111 |
| 2010-08-26 | @ PHI | 127 | W 5-1 | - | | 44,958 | Wandy Rodriguez | Kyle Kendrick | Wandy Rodriguez | Kyle Kendrick | | 483 | 590 | -107 |
| 2010-08-27 | @ NYN | 128 | L 1-2 | - | | 30,178 | Nelson Figueroa | Mike Pelfrey | Mike Pelfrey | Nelson Figueroa | Hisanori Takahashi | 484 | 592 | -108 |
| 2010-08-28 | @ NYN | 129 | W 4-1 | - | | 33,024 | Brett Myers | Johan Santana | Brett Myers | Johan Santana | Brandon Lyon | 488 | 593 | -105 |
| 2010-08-29 | @ NYN | 130 | L 1-5 | - | | 32,779 | Bud Norris | R.A. Dickey | R.A. Dickey | Bud Norris | | 489 | 598 | -109 |
| 2010-08-30 | vs SLN | 131 | W 3-0 | - | | 23,140 | J.A. Happ | Jake Westbrook | J.A. Happ | Jake Westbrook | | 492 | 598 | -106 |
| 2010-08-31 | vs SLN | 132 | W 3-0 | - | | 29,307 | Wandy Rodriguez | Chris Carpenter | Wandy Rodriguez | Chris Carpenter | Brandon Lyon | 495 | 598 | -103 |
| 2010-09-01 | vs SLN | 133 | W 5-2 | - | | 22,068 | Nelson Figueroa | Jeff Suppan | Nelson Figueroa | Jeff Suppan | Brandon Lyon | 500 | 600 | -100 |
| 2010-09-03 | @ ARI | 134 | L 3-4 | - | | 24,748 | Brett Myers | Daniel Hudson | Aaron Heilman | Wilton Lopez | Juan Gutierrez | 503 | 604 | -101 |
| 2010-09-04 | @ ARI | 135 | W 6-5 | - | | 31,605 | Bud Norris | Joe Saunders | Mark Melancon | Aaron Heilman | Brandon Lyon | 509 | 609 | -100 |
| 2010-09-05 | @ ARI | 136 | W 3-2 | - | | 25,416 | J.A. Happ | Rodrigo Lopez | J.A. Happ | Rodrigo Lopez | Brandon Lyon | 512 | 611 | -99 |
| 2010-09-06 | @ CHN | 137 | L 4-5 | - | | 31,647 | Wandy Rodriguez | Casey Coleman | Andrew Cashner | Wilton Lopez | Carlos Marmol | 516 | 616 | -100 |
| 2010-09-07 | @ CHN | 138 | W 7-3 | - | | 31,596 | Nelson Figueroa | Carlos Silva | Nelson Figueroa | Carlos Silva | | 523 | 619 | -96 |
| 2010-09-08 | @ CHN | 139 | W 4-0 | - | | 33,623 | Brett Myers | Randy Wells | Brett Myers | Randy Wells | | 527 | 619 | -92 |
| 2010-09-09 | vs LAN | 140 | W 3-2 | - | | 28,081 | Bud Norris | Ted Lilly | Bud Norris | Ted Lilly | Brandon Lyon | 530 | 621 | -91 |
| 2010-09-10 | vs LAN | 141 | L 2-4 | - | | 31,010 | J.A. Happ | Hiroki Kuroda | Octavio Dotel | Fernando Abad | | 532 | 625 | -93 |
| 2010-09-11 | vs LAN | 142 | L 3-6 | - | | 39,237 | Wandy Rodriguez | John Ely | Kenley Jansen | Brandon Lyon | Hong-Chih Kuo | 535 | 631 | -96 |
| 2010-09-12 | vs LAN | 143 | W 7-4 | - | | 30,240 | Nelson Figueroa | Carlos Monasterios | Gustavo Chacin | Ramon Troncoso | Brandon Lyon | 542 | 635 | -93 |
| 2010-09-13 | vs MIL | 144 | W 4-2 | - | | 31,342 | Brett Myers | Chris Narveson | Brett Myers | Brandon Kintzler | Matt Lindstrom | 546 | 637 | -91 |
| 2010-09-14 | vs MIL | 145 | W 3-2 | - | | 33,878 | Bud Norris | Chris Capuano | Bud Norris | Chris Capuano | Brandon Lyon | 549 | 639 | -90 |
| 2010-09-15 | vs MIL | 146 | L 6-8 | - | | 30,791 | J.A. Happ | David Bush | John Axford | Matt Lindstrom | | 555 | 647 | -92 |
| 2010-09-17 | vs CIN | 147 | W 5-3 | - | | 30,218 | Wandy Rodriguez | Johnny Cueto | Jeff Fulchino | Aroldis Chapman | Brandon Lyon | 560 | 650 | -90 |
| 2010-09-18 | vs CIN | 148 | L 1-11 | - | | 29,855 | Nelson Figueroa | Bronson Arroyo | Bronson Arroyo | Nelson Figueroa | | 561 | 661 | -100 |
| 2010-09-19 | vs CIN | 149 | W 4-3 | - | | 32,520 | Brett Myers | Travis Wood | Brett Myers | Travis Wood | Brandon Lyon | 565 | 664 | -99 |
| 2010-09-20 | @ WAS | 150 | W 8-2 | - | | 10,999 | Bud Norris | Livan Hernandez | Bud Norris | Livan Hernandez | | 573 | 666 | -93 |
| 2010-09-21 | @ WAS | 151 | L 4-8 | - | | 11,893 | J.A. Happ | John Lannan | Tyler Clippard | Felipe Paulino | | 577 | 674 | -97 |
| 2010-09-22 | @ WAS | 152 | L 3-4 | - | | 12,213 | Wandy Rodriguez | Jason Marquis | Tyler Clippard | Jeff Fulchino | Sean Burnett | 580 | 678 | -98 |
| 2010-09-23 | @ WAS | 153 | L 2-7 | - | | 14,633 | Nelson Figueroa | Ross Detwiler | Ross Detwiler | Nelson Figueroa | | 582 | 685 | -103 |
| 2010-09-24 | @ PIT | 154 | W 10-7 | - | | 22,279 | Brett Myers | James McDonald | Brett Myers | Chris Leroux | Brandon Lyon | 592 | 692 | -100 |
| 2010-09-25 | @ PIT | 155 | L 4-6 | - | | 25,350 | Bud Norris | Zach Duke | Zach Duke | Bud Norris | Joel Hanrahan | 596 | 698 | -102 |
| 2010-09-26 | @ PIT | 156 | L 3-9 | - | | 23,208 | J.A. Happ | Paul Maholm | Paul Maholm | J.A. Happ | | 599 | 707 | -108 |
| 2010-09-28 | @ CIN | 157 | L 2-3 | - | | 30,151 | Wandy Rodriguez | Edinson Volquez | Aroldis Chapman | Tim Byrdak | | 601 | 710 | -109 |
| 2010-09-29 | @ CIN | 158 | W 2-0 | - | | 14,760 | Nelson Figueroa | Johnny Cueto | Nelson Figueroa | Johnny Cueto | Brandon Lyon | 603 | 710 | -107 |
| 2010-09-30 | @ CIN | 159 | L 1-9 | - | | 17,558 | Brett Myers | Bronson Arroyo | Bronson Arroyo | Brett Myers | | 604 | 719 | -115 |
| 2010-10-01 | vs CHN | 160 | L 0-2 | - | | 33,869 | Bud Norris | Casey Coleman | Casey Coleman | Bud Norris | Carlos Marmol | 604 | 721 | -117 |
| 2010-10-02 | vs CHN | 161 | L 3-8 | - | | 36,098 | J.A. Happ | Carlos Zambrano | Carlos Zambrano | J.A. Happ | | 607 | 729 | -122 |
| 2010-10-03 | vs CHN | 162 | W 4-0 | - | | 31,105 | Nelson Figueroa | Ryan Dempster | Nelson Figueroa | Ryan Dempster | | 611 | 729 | -118 |