| West | W | L | Pct | GB |
| SF Giants | 92 | 70 | .568 | -- |
| San Diego | 90 | 72 | .556 | 2.0 |
| Colorado | 83 | 79 | .512 | 9.0 |
| LA Dodgers | 80 | 82 | .494 | 12.0 |
| Arizona | 65 | 97 | .401 | 27.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 2010-04-05 | Ubaldo Jimenez | R | 26 | W 5-3 | @ MIL | 1 | 84 | W | 6.0 | 8 | 1 | 1 | 0 | 1 | 6 | 102 | 35 | 67 | 66% | 1-0 | 1.50 | 1.50 |
| 2010-04-06 | Greg Smith | L | 26 | L 5-7 | @ MIL | 1 | 33 | L | 5.0 | 4 | 5 | 5 | 2 | 2 | 5 | 91 | 33 | 58 | 64% | 0-1 | 9.00 | 1.20 |
| 2010-04-07 | Aaron Cook | R | 31 | L 4-5 | @ MIL | 1 | 167 | L | 5.1 | 7 | 5 | 4 | 0 | 1 | 5 | 92 | 40 | 52 | 57% | 0-1 | 7.20 | 1.60 |
| 2010-04-09 | Jorge De La Rosa | L | 29 | L 7-0 | vs SDN | 1 | 97 | W | 7.0 | 1 | 0 | 0 | 0 | 1 | 9 | 95 | 34 | 61 | 64% | 1-0 | 0.00 | 0.29 |
| 2010-04-10 | Jason Hammel | R | 28 | W 4-5 | vs SDN | 1 | 59 | - | 7.0 | 6 | 4 | 4 | 0 | 3 | 4 | 100 | 39 | 61 | 61% | 0-0 | 5.14 | 1.29 |
| 2010-04-11 | Ubaldo Jimenez | R | 26 | L 4-2 | vs SDN | 2 | 85 | W | 6.0 | 7 | 2 | 2 | 0 | 3 | 7 | 115 | 39 | 76 | 66% | 2-0 | 2.25 | 1.58 |
| 2010-04-13 | Greg Smith | L | 26 | L 11-3 | vs NYN | 2 | 34 | W | 7.0 | 6 | 2 | 2 | 1 | 2 | 8 | 103 | 36 | 67 | 65% | 1-1 | 5.25 | 1.17 |
| 2010-04-14 | Aaron Cook | R | 31 | L 6-5 | vs NYN | 2 | 168 | - | 6.0 | 4 | 3 | 3 | 2 | 4 | 4 | 102 | 45 | 57 | 56% | 0-1 | 5.73 | 1.45 |
| 2010-04-15 | Jorge De La Rosa | L | 29 | W 0-5 | vs NYN | 2 | 98 | L | 6.0 | 8 | 5 | 4 | 0 | 5 | 5 | 97 | 41 | 56 | 58% | 1-1 | 2.77 | 1.15 |
| 2010-04-16 | Jason Hammel | R | 28 | L 5-9 | @ ATL | 2 | 60 | L | 1.2 | 8 | 7 | 7 | 0 | 3 | 1 | 67 | 33 | 34 | 51% | 0-1 | 11.00 | 2.22 |
| 2010-04-17 | Ubaldo Jimenez | R | 26 | W 4-0 | @ ATL | 3 | 86 | W | 9.0 | 0 | 0 | 0 | 0 | 6 | 7 | 129 | 56 | 73 | 57% | 3-0 | 1.29 | 1.19 |
| 2010-04-18 | Greg Smith | L | 26 | L 3-4 | @ ATL | 3 | 35 | - | 5.1 | 5 | 2 | 2 | 0 | 7 | 5 | 108 | 53 | 55 | 51% | 1-1 | 4.76 | 1.53 |
| 2010-04-19 | Aaron Cook | R | 31 | L 2-5 | @ WAS | 3 | 169 | L | 3.0 | 7 | 5 | 5 | 1 | 4 | 2 | 83 | 37 | 46 | 55% | 0-2 | 7.71 | 1.93 |
| 2010-04-20 | Jorge De La Rosa | L | 29 | W 10-4 | @ WAS | 3 | 99 | W | 5.0 | 7 | 4 | 4 | 1 | 4 | 6 | 117 | 52 | 65 | 56% | 2-1 | 4.00 | 1.44 |
| 2010-04-21 | Jason Hammel | R | 28 | L 4-6 | @ WAS | 3 | 61 | - | 7.0 | 8 | 4 | 3 | 0 | 1 | 6 | 118 | 46 | 72 | 61% | 0-1 | 7.88 | 1.81 |
| 2010-04-22 | Ubaldo Jimenez | R | 26 | W 2-0 | @ WAS | 4 | 87 | W | 7.1 | 5 | 0 | 0 | 0 | 2 | 5 | 127 | 46 | 81 | 64% | 4-0 | 0.96 | 1.14 |
| 2010-04-24 | Greg Smith | L | 26 | W 1-4 | vs FLO | 4 | 36 | L | 5.0 | 8 | 4 | 4 | 2 | 1 | 1 | 79 | 27 | 52 | 66% | 1-2 | 5.32 | 1.59 |
| 2010-04-24 | Aaron Cook | R | 31 | L 8-1 | vs FLO | 4 | 170 | W | 9.0 | 5 | 1 | 1 | 0 | 2 | 4 | 111 | 33 | 78 | 70% | 1-2 | 5.09 | 1.48 |
| 2010-04-25 | Jorge De La Rosa | L | 29 | L 8-4 | vs FLO | 4 | 100 | W | 5.0 | 4 | 2 | 2 | 0 | 3 | 6 | 94 | 39 | 55 | 59% | 3-1 | 3.91 | 1.43 |
| 2010-04-26 | Jason Hammel | R | 28 | W 3-5 | vs ARI | 4 | 62 | L | 3.0 | 6 | 5 | 5 | 1 | 1 | 2 | 64 | 27 | 37 | 58% | 0-2 | 9.00 | 1.89 |
| 2010-04-27 | Ubaldo Jimenez | R | 26 | L 12-1 | vs ARI | 5 | 88 | W | 6.0 | 2 | 0 | 0 | 0 | 2 | 6 | 95 | 35 | 60 | 63% | 5-0 | 0.79 | 1.06 |
| 2010-04-28 | Greg Smith | L | 26 | W 11-12 | vs ARI | 5 | 37 | - | 1.0 | 4 | 6 | 6 | 1 | 3 | 0 | 31 | 17 | 14 | 45% | 1-2 | 7.43 | 1.83 |
| 2010-04-30 | Aaron Cook | R | 31 | L 2-5 | @ SFN | 5 | 171 | L | 6.0 | 7 | 5 | 5 | 0 | 5 | 1 | 95 | 43 | 52 | 55% | 1-3 | 5.59 | 1.59 |
| 2010-05-01 | Esmil Rogers | R | 25 | L 1-6 | @ SFN | 1 | 2 | L | 4.0 | 5 | 5 | 4 | 2 | 4 | 2 | 96 | 38 | 58 | 60% | 0-1 | 5.63 | 1.63 |
| 2010-05-02 | Jhoulys Chacin | R | 22 | W 4-1 | @ SFN | 1 | 2 | W | 7.0 | 1 | 0 | 0 | 0 | 3 | 7 | 97 | 39 | 58 | 60% | 1-0 | 0.00 | 0.50 |
| 2010-05-03 | Ubaldo Jimenez | R | 26 | W 5-2 | @ SDN | 6 | 89 | W | 7.0 | 4 | 1 | 1 | 0 | 2 | 13 | 125 | 49 | 76 | 61% | 6-0 | 0.88 | 1.02 |
| 2010-05-04 | Greg Smith | L | 26 | L 2-3 | @ SDN | 6 | 38 | - | 5.0 | 4 | 1 | 1 | 0 | 5 | 2 | 102 | 46 | 56 | 55% | 1-2 | 6.43 | 1.82 |
| 2010-05-05 | Aaron Cook | R | 31 | W 6-5 | @ SDN | 6 | 172 | - | 5.0 | 6 | 5 | 5 | 0 | 2 | 2 | 85 | 34 | 51 | 60% | 1-3 | 6.09 | 1.59 |
| 2010-05-07 | Esmil Rogers | R | 25 | L 5-6 | @ LAN | 2 | 3 | - | 4.2 | 7 | 5 | 4 | 0 | 2 | 5 | 112 | 49 | 63 | 56% | 0-1 | 6.23 | 1.69 |
| 2010-05-08 | Jhoulys Chacin | R | 22 | W 8-0 | @ LAN | 2 | 3 | W | 7.1 | 6 | 0 | 0 | 0 | 2 | 7 | 116 | 44 | 72 | 62% | 2-0 | 0.00 | 0.80 |
| 2010-05-09 | Ubaldo Jimenez | R | 26 | L 0-2 | @ LAN | 7 | 90 | L | 7.0 | 2 | 1 | 1 | 0 | 4 | 5 | 107 | 46 | 61 | 57% | 6-1 | 0.94 | 1.00 |
| 2010-05-10 | Greg Smith | L | 26 | W 5-9 | vs PHI | 7 | 39 | - | 5.2 | 8 | 5 | 4 | 1 | 4 | 6 | 113 | 40 | 73 | 65% | 1-2 | 6.35 | 1.85 |
| 2010-05-12 | Aaron Cook | R | 31 | L 4-3 | vs PHI | 7 | 173 | - | 6.0 | 8 | 3 | 3 | 0 | 2 | 3 | 86 | 29 | 57 | 66% | 1-3 | 5.85 | 1.60 |
| 2010-05-13 | Jhoulys Chacin | R | 22 | W 6-14 | vs WAS | 3 | 4 | L | 5.0 | 6 | 6 | 6 | 2 | 1 | 3 | 84 | 33 | 51 | 61% | 2-1 | 2.70 | 0.95 |
| 2010-05-15 | Ubaldo Jimenez | R | 26 | L 6-2 | vs WAS | 8 | 91 | W | 8.0 | 7 | 2 | 2 | 1 | 1 | 5 | 114 | 45 | 69 | 61% | 7-1 | 1.13 | 1.00 |
| 2010-05-15 | Jason Hammel | R | 28 | L 4-3 | vs WAS | 5 | 63 | W | 7.0 | 6 | 3 | 3 | 1 | 0 | 7 | 92 | 29 | 63 | 68% | 1-2 | 7.62 | 1.62 |
| 2010-05-16 | Jeff Francis | L | 29 | L 2-1 | vs WAS | 1 | 131 | - | 7.0 | 7 | 1 | 1 | 0 | 2 | 6 | 103 | 39 | 64 | 62% | 0-0 | 1.29 | 1.29 |
| 2010-05-17 | Aaron Cook | R | 31 | L 2-4 | @ CHN | 8 | 174 | - | 7.0 | 7 | 2 | 1 | 0 | 1 | 3 | 82 | 30 | 52 | 63% | 1-3 | 5.17 | 1.53 |
| 2010-05-18 | Jhoulys Chacin | R | 22 | L 2-6 | @ CHN | 4 | 5 | L | 5.2 | 5 | 3 | 3 | 0 | 5 | 6 | 103 | 49 | 54 | 52% | 2-2 | 3.12 | 1.12 |
| 2010-05-19 | Greg Smith | L | 26 | L 3-7 | @ HOU | 8 | 40 | - | 5.0 | 10 | 3 | 3 | 1 | 0 | 4 | 83 | 28 | 55 | 66% | 1-2 | 6.23 | 1.87 |
| 2010-05-20 | Ubaldo Jimenez | R | 26 | W 4-0 | @ HOU | 9 | 92 | W | 7.0 | 1 | 0 | 0 | 0 | 2 | 4 | 91 | 39 | 52 | 57% | 8-1 | 1.00 | 0.94 |
| 2010-05-21 | Jason Hammel | R | 28 | L 2-9 | @ KCA | 6 | 64 | L | 6.2 | 6 | 5 | 5 | 2 | 1 | 6 | 89 | 30 | 59 | 66% | 1-3 | 7.59 | 1.53 |
| 2010-05-22 | Jeff Francis | L | 29 | W 3-0 | @ KCA | 2 | 132 | W | 6.1 | 5 | 0 | 0 | 0 | 2 | 3 | 100 | 36 | 64 | 64% | 1-0 | 0.69 | 1.23 |
| 2010-05-23 | Aaron Cook | R | 31 | W 11-7 | @ KCA | 9 | 175 | - | 4.1 | 9 | 4 | 4 | 0 | 4 | 1 | 92 | 39 | 53 | 58% | 1-3 | 5.37 | 1.63 |
| 2010-05-25 | Jhoulys Chacin | R | 22 | L 3-2 | vs ARI | 5 | 6 | W | 6.0 | 4 | 2 | 2 | 0 | 2 | 5 | 97 | 35 | 62 | 64% | 3-2 | 3.09 | 1.09 |
| 2010-05-26 | Ubaldo Jimenez | R | 26 | L 7-3 | vs ARI | 10 | 93 | W | 8.0 | 6 | 0 | 0 | 0 | 1 | 3 | 100 | 40 | 60 | 60% | 9-1 | 0.89 | 0.93 |
| 2010-05-27 | Jason Hammel | R | 28 | L 8-2 | vs ARI | 7 | 65 | W | 5.1 | 7 | 2 | 2 | 0 | 2 | 8 | 91 | 30 | 61 | 67% | 2-3 | 6.87 | 1.53 |
| 2010-05-28 | Jeff Francis | L | 29 | W 4-5 | vs LAN | 3 | 133 | L | 5.1 | 5 | 5 | 5 | 2 | 1 | 2 | 84 | 29 | 55 | 65% | 1-1 | 2.84 | 1.16 |
| 2010-05-29 | Aaron Cook | R | 31 | L 11-3 | vs LAN | 10 | 176 | W | 6.1 | 6 | 3 | 1 | 0 | 2 | 1 | 91 | 32 | 59 | 65% | 2-3 | 4.97 | 1.60 |
| 2010-05-30 | Jhoulys Chacin | R | 22 | W 3-4 | vs LAN | 6 | 7 | L | 5.1 | 7 | 4 | 4 | 0 | 2 | 6 | 87 | 30 | 57 | 66% | 3-3 | 3.65 | 1.19 |
| 2010-05-31 | Ubaldo Jimenez | R | 26 | W 4-0 | @ SFN | 11 | 94 | W | 9.0 | 4 | 0 | 0 | 0 | 2 | 9 | 137 | 53 | 84 | 61% | 10-1 | 0.79 | 0.90 |
| 2010-06-01 | Jason Hammel | R | 28 | W 2-1 | @ SFN | 8 | 66 | - | 6.2 | 7 | 1 | 1 | 1 | 0 | 5 | 98 | 38 | 60 | 61% | 2-3 | 6.14 | 1.48 |
| 2010-06-02 | Jeff Francis | L | 29 | L 1-4 | @ SFN | 4 | 134 | L | 5.2 | 8 | 4 | 4 | 0 | 1 | 3 | 81 | 29 | 52 | 64% | 1-2 | 3.75 | 1.29 |
| 2010-06-04 | Aaron Cook | R | 31 | L 6-7 | @ ARI | 11 | 177 | - | 5.0 | 4 | 3 | 3 | 1 | 2 | 5 | 84 | 33 | 51 | 61% | 2-3 | 5.00 | 1.57 |
| 2010-06-05 | Jhoulys Chacin | R | 22 | L 3-4 | @ ARI | 7 | 8 | L | 5.2 | 6 | 4 | 3 | 0 | 3 | 9 | 128 | 55 | 73 | 57% | 3-4 | 3.77 | 1.23 |
| 2010-06-06 | Ubaldo Jimenez | R | 26 | W 3-2 | @ ARI | 12 | 95 | W | 7.0 | 6 | 2 | 2 | 1 | 3 | 8 | 116 | 47 | 69 | 59% | 11-1 | 0.93 | 0.93 |
| 2010-06-07 | Jason Hammel | R | 28 | L 5-1 | vs HOU | 9 | 67 | W | 7.1 | 6 | 0 | 0 | 0 | 3 | 3 | 104 | 42 | 62 | 60% | 3-3 | 5.19 | 1.42 |
| 2010-06-08 | Jeff Francis | L | 29 | W 3-4 | vs HOU | 5 | 135 | - | 7.0 | 7 | 2 | 2 | 0 | 0 | 1 | 83 | 31 | 52 | 63% | 1-2 | 3.48 | 1.23 |
| 2010-06-09 | Aaron Cook | R | 31 | W 2-6 | vs HOU | 12 | 178 | - | 7.0 | 5 | 2 | 2 | 0 | 1 | 0 | 86 | 32 | 54 | 63% | 2-3 | 4.76 | 1.50 |
| 2010-06-10 | Jhoulys Chacin | R | 22 | W 4-5 | vs HOU | 8 | 9 | L | 6.0 | 4 | 5 | 4 | 1 | 3 | 8 | 96 | 36 | 60 | 63% | 3-5 | 4.04 | 1.22 |
| 2010-06-11 | Ubaldo Jimenez | R | 26 | L 5-3 | vs TOR | 13 | 96 | W | 6.0 | 5 | 3 | 3 | 1 | 5 | 6 | 106 | 49 | 57 | 54% | 12-1 | 1.16 | 0.98 |
| 2010-06-12 | Jason Hammel | R | 28 | L 1-0 | vs TOR | 10 | 68 | W | 8.0 | 3 | 0 | 0 | 0 | 3 | 6 | 105 | 36 | 69 | 66% | 4-3 | 4.50 | 1.33 |
| 2010-06-13 | Jeff Francis | L | 29 | L 10-3 | vs TOR | 6 | 136 | W | 7.0 | 5 | 3 | 2 | 0 | 2 | 4 | 100 | 43 | 57 | 57% | 2-2 | 3.32 | 1.18 |
| 2010-06-15 | Aaron Cook | R | 31 | L 3-9 | @ MIN | 13 | 179 | L | 3.1 | 9 | 5 | 5 | 0 | 3 | 0 | 69 | 32 | 37 | 54% | 2-4 | 5.18 | 1.60 |
| 2010-06-16 | Jhoulys Chacin | R | 22 | L 1-2 | @ MIN | 9 | 10 | L | 5.0 | 7 | 2 | 2 | 0 | 3 | 1 | 89 | 40 | 49 | 55% | 3-6 | 4.00 | 1.30 |
| 2010-06-17 | Ubaldo Jimenez | R | 26 | W 5-1 | @ MIN | 14 | 97 | W | 8.0 | 8 | 1 | 1 | 0 | 2 | 4 | 115 | 51 | 64 | 56% | 13-1 | 1.16 | 1.00 |
| 2010-06-18 | Jason Hammel | R | 28 | L 2-0 | vs MIL | 11 | 69 | W | 7.1 | 8 | 0 | 0 | 0 | 2 | 4 | 108 | 33 | 75 | 69% | 5-3 | 4.03 | 1.34 |
| 2010-06-19 | Jeff Francis | L | 29 | L 8-7 | vs MIL | 7 | 137 | - | 6.1 | 8 | 4 | 3 | 0 | 0 | 5 | 95 | 35 | 60 | 63% | 2-2 | 3.40 | 1.18 |
| 2010-06-20 | Aaron Cook | R | 31 | W 1-6 | vs MIL | 14 | 180 | - | 7.0 | 3 | 1 | 1 | 0 | 4 | 5 | 96 | 42 | 54 | 56% | 2-4 | 4.84 | 1.55 |
| 2010-06-22 | Jhoulys Chacin | R | 22 | L 2-1 | vs BOS | 10 | 11 | W | 6.2 | 4 | 0 | 0 | 0 | 5 | 5 | 103 | 43 | 60 | 58% | 4-6 | 3.54 | 1.30 |
| 2010-06-23 | Ubaldo Jimenez | R | 26 | L 8-6 | vs BOS | 15 | 98 | - | 5.2 | 10 | 6 | 6 | 1 | 0 | 7 | 106 | 34 | 72 | 68% | 13-1 | 1.60 | 1.04 |
| 2010-06-24 | Jason Hammel | R | 28 | W 11-13 | vs BOS | 12 | 70 | - | 4.0 | 7 | 4 | 4 | 1 | 1 | 4 | 87 | 33 | 54 | 62% | 5-3 | 4.31 | 1.38 |
| 2010-06-25 | Jeff Francis | L | 29 | W 4-3 | @ ANA | 8 | 138 | - | 6.1 | 7 | 3 | 3 | 0 | 1 | 3 | 94 | 32 | 62 | 66% | 2-2 | 3.53 | 1.20 |
| 2010-06-26 | Aaron Cook | R | 31 | L 2-4 | @ ANA | 15 | 181 | L | 8.0 | 4 | 4 | 3 | 1 | 1 | 3 | 99 | 40 | 59 | 60% | 2-5 | 4.70 | 1.47 |
| 2010-06-27 | Jhoulys Chacin | R | 22 | L 3-10 | @ ANA | 11 | 12 | L | 6.0 | 5 | 5 | 2 | 1 | 3 | 12 | 110 | 44 | 66 | 60% | 4-7 | 3.49 | 1.30 |
| 2010-06-28 | Ubaldo Jimenez | R | 26 | W 10-6 | @ SDN | 16 | 99 | W | 6.0 | 4 | 4 | 4 | 1 | 4 | 7 | 99 | 41 | 58 | 59% | 14-1 | 1.83 | 1.05 |
| 2010-06-29 | Jason Hammel | R | 28 | W 6-3 | @ SDN | 13 | 71 | W | 6.0 | 7 | 3 | 3 | 1 | 1 | 4 | 95 | 35 | 60 | 63% | 6-3 | 4.32 | 1.38 |
| 2010-06-30 | Jeff Francis | L | 29 | L 3-13 | @ SDN | 9 | 139 | L | 3.0 | 7 | 8 | 8 | 0 | 3 | 0 | 80 | 38 | 42 | 53% | 2-3 | 4.67 | 1.31 |
| 2010-07-01 | Aaron Cook | R | 31 | L 7-3 | vs SFN | 16 | 182 | W | 6.1 | 7 | 3 | 3 | 1 | 1 | 4 | 98 | 37 | 61 | 62% | 3-5 | 4.64 | 1.44 |
| 2010-07-02 | Jhoulys Chacin | R | 22 | L 6-3 | vs SFN | 12 | 13 | W | 6.0 | 5 | 3 | 3 | 2 | 2 | 5 | 101 | 40 | 61 | 60% | 5-7 | 3.58 | 1.29 |
| 2010-07-03 | Ubaldo Jimenez | R | 26 | W 8-11 | vs SFN | 17 | 100 | - | 6.0 | 5 | 7 | 7 | 1 | 4 | 5 | 101 | 41 | 60 | 59% | 14-1 | 2.27 | 1.08 |
| 2010-07-04 | Jason Hammel | R | 28 | L 4-3 | vs SFN | 14 | 72 | - | 7.0 | 7 | 2 | 2 | 2 | 1 | 8 | 109 | 32 | 77 | 71% | 6-3 | 4.18 | 1.36 |
| 2010-07-06 | Jeff Francis | L | 29 | L 12-9 | vs SLN | 10 | 140 | - | 4.0 | 6 | 5 | 5 | 1 | 2 | 1 | 67 | 25 | 42 | 63% | 2-3 | 5.12 | 1.36 |
| 2010-07-07 | Aaron Cook | R | 31 | L 8-7 | vs SLN | 17 | 183 | - | 5.0 | 10 | 5 | 5 | 2 | 1 | 1 | 80 | 32 | 48 | 60% | 3-5 | 4.86 | 1.48 |
| 2010-07-08 | Ubaldo Jimenez | R | 26 | L 4-2 | vs SLN | 18 | 101 | W | 8.0 | 3 | 1 | 1 | 0 | 2 | 6 | 94 | 33 | 61 | 65% | 15-1 | 2.20 | 1.05 |
| 2010-07-09 | Jorge De La Rosa | L | 29 | L 10-8 | vs SDN | 5 | 101 | - | 4.1 | 6 | 7 | 5 | 1 | 1 | 6 | 95 | 34 | 61 | 64% | 3-1 | 5.00 | 1.48 |
| 2010-07-10 | Jason Hammel | R | 28 | L 4-2 | vs SDN | 15 | 73 | W | 6.1 | 5 | 2 | 2 | 0 | 2 | 4 | 89 | 28 | 61 | 69% | 7-3 | 4.10 | 1.34 |
| 2010-07-11 | Jeff Francis | L | 30 | W 7-9 | vs SDN | 11 | 141 | - | 5.0 | 8 | 3 | 3 | 0 | 3 | 3 | 94 | 34 | 60 | 64% | 2-3 | 5.14 | 1.43 |
| 2010-07-16 | Jason Hammel | R | 28 | L 2-3 | @ CIN | 16 | 74 | L | 7.0 | 8 | 3 | 3 | 0 | 1 | 10 | 101 | 31 | 70 | 69% | 7-4 | 4.08 | 1.34 |
| 2010-07-17 | Jorge De La Rosa | L | 29 | L 1-8 | @ CIN | 6 | 102 | L | 3.1 | 4 | 7 | 6 | 3 | 5 | 0 | 61 | 32 | 29 | 48% | 3-2 | 6.10 | 1.58 |
| 2010-07-18 | Aaron Cook | R | 31 | W 1-0 | @ CIN | 18 | 184 | W | 7.0 | 6 | 0 | 0 | 0 | 1 | 5 | 81 | 24 | 57 | 70% | 4-5 | 4.54 | 1.45 |
| 2010-07-19 | Ubaldo Jimenez | R | 26 | L 8-9 | @ FLO | 19 | 102 | - | 5.1 | 6 | 6 | 4 | 1 | 3 | 5 | 97 | 41 | 56 | 58% | 15-1 | 2.39 | 1.08 |
| 2010-07-20 | Jeff Francis | L | 30 | W 10-0 | @ FLO | 12 | 142 | W | 7.0 | 3 | 0 | 0 | 0 | 0 | 7 | 96 | 25 | 71 | 74% | 3-3 | 4.63 | 1.33 |
| 2010-07-21 | Jason Hammel | R | 28 | L 2-5 | @ FLO | 17 | 75 | L | 7.0 | 6 | 5 | 5 | 1 | 3 | 5 | 111 | 41 | 70 | 63% | 7-5 | 4.24 | 1.34 |
| 2010-07-22 | Jorge De La Rosa | L | 29 | L 2-3 | @ FLO | 7 | 103 | - | 6.0 | 3 | 2 | 2 | 1 | 3 | 8 | 100 | 44 | 56 | 56% | 3-2 | 5.59 | 1.49 |
| 2010-07-23 | Aaron Cook | R | 31 | L 0-6 | @ PHI | 19 | 185 | L | 4.1 | 9 | 5 | 5 | 1 | 3 | 2 | 83 | 40 | 43 | 52% | 4-6 | 4.78 | 1.50 |
| 2010-07-24 | Ubaldo Jimenez | R | 27 | L 2-10 | @ PHI | 20 | 103 | L | 2.0 | 3 | 6 | 6 | 0 | 6 | 2 | 65 | 39 | 26 | 40% | 15-2 | 2.75 | 1.13 |
| 2010-07-25 | Jeff Francis | L | 30 | L 3-4 | @ PHI | 13 | 143 | - | 5.0 | 6 | 2 | 2 | 1 | 1 | 6 | 94 | 34 | 60 | 64% | 3-3 | 4.56 | 1.33 |
| 2010-07-26 | Jason Hammel | R | 28 | L 4-5 | @ PHI | 18 | 76 | L | 5.2 | 7 | 5 | 4 | 0 | 3 | 8 | 118 | 45 | 73 | 62% | 7-6 | 4.34 | 1.35 |
| 2010-07-27 | Jorge De La Rosa | L | 29 | W 2-4 | vs PIT | 8 | 104 | L | 7.0 | 6 | 3 | 2 | 0 | 2 | 8 | 92 | 28 | 64 | 70% | 3-3 | 5.11 | 1.43 |
| 2010-07-28 | Aaron Cook | R | 31 | W 2-6 | vs PIT | 20 | 186 | L | 2.1 | 6 | 5 | 5 | 1 | 1 | 2 | 68 | 23 | 45 | 66% | 4-7 | 5.10 | 1.54 |
| 2010-07-29 | Ubaldo Jimenez | R | 27 | L 9-3 | vs PIT | 21 | 104 | W | 7.0 | 4 | 1 | 1 | 0 | 3 | 6 | 120 | 50 | 70 | 58% | 16-2 | 2.68 | 1.12 |
| 2010-07-30 | Jeff Francis | L | 30 | L 17-2 | vs CHN | 14 | 144 | W | 6.0 | 4 | 2 | 2 | 0 | 1 | 5 | 87 | 35 | 52 | 60% | 4-3 | 4.44 | 1.30 |
| 2010-07-31 | Jason Hammel | R | 28 | L 6-5 | vs CHN | 19 | 77 | - | 7.1 | 6 | 4 | 4 | 0 | 0 | 5 | 81 | 23 | 58 | 72% | 7-6 | 4.38 | 1.32 |
| 2010-08-01 | Jorge De La Rosa | L | 29 | L 8-7 | vs CHN | 9 | 105 | W | 6.2 | 8 | 3 | 3 | 0 | 2 | 5 | 102 | 33 | 69 | 68% | 4-3 | 5.04 | 1.46 |
| 2010-08-03 | Aaron Cook | R | 31 | W 0-10 | vs SFN | 21 | 187 | L | 3.0 | 8 | 5 | 5 | 1 | 2 | 2 | 58 | 28 | 30 | 52% | 4-8 | 5.35 | 1.59 |
| 2010-08-04 | Ubaldo Jimenez | R | 27 | L 6-1 | vs SFN | 22 | 105 | W | 7.0 | 4 | 1 | 1 | 0 | 2 | 9 | 117 | 49 | 68 | 58% | 17-2 | 2.61 | 1.11 |
| 2010-08-05 | Jeff Francis | L | 30 | L 1-5 | @ PIT | 15 | 145 | L | 5.2 | 9 | 5 | 5 | 2 | 0 | 5 | 81 | 25 | 56 | 69% | 4-4 | 4.66 | 1.31 |
| 2010-08-06 | Jason Hammel | R | 28 | W 6-3 | @ PIT | 20 | 78 | W | 6.0 | 3 | 3 | 3 | 1 | 2 | 2 | 94 | 38 | 56 | 60% | 8-6 | 4.39 | 1.30 |
| 2010-08-07 | Jorge De La Rosa | L | 29 | L 7-8 | @ PIT | 10 | 106 | - | 5.1 | 5 | 3 | 3 | 1 | 4 | 5 | 113 | 47 | 66 | 58% | 4-3 | 4.98 | 1.46 |
| 2010-08-08 | Esmil Rogers | R | 25 | W 8-4 | @ PIT | 3 | 4 | W | 6.0 | 8 | 4 | 3 | 0 | 1 | 3 | 127 | 49 | 78 | 61% | 2-2 | 4.75 | 1.53 |
| 2010-08-10 | Ubaldo Jimenez | R | 27 | L 0-1 | @ NYN | 23 | 106 | L | 7.0 | 4 | 1 | 1 | 0 | 4 | 8 | 119 | 49 | 70 | 59% | 17-3 | 2.55 | 1.11 |
| 2010-08-11 | Jeff Francis | L | 30 | W 6-2 | @ NYN | 16 | 146 | - | 6.0 | 3 | 2 | 2 | 1 | 1 | 5 | 81 | 33 | 48 | 59% | 4-4 | 4.55 | 1.27 |
| 2010-08-12 | Jason Hammel | R | 28 | L 0-4 | @ NYN | 21 | 79 | L | 7.0 | 8 | 4 | 4 | 0 | 1 | 4 | 112 | 32 | 80 | 71% | 8-7 | 4.43 | 1.30 |
| 2010-08-13 | Jorge De La Rosa | L | 29 | L 5-4 | vs MIL | 11 | 107 | - | 5.2 | 6 | 3 | 3 | 0 | 3 | 5 | 114 | 49 | 65 | 57% | 4-3 | 5.02 | 1.49 |
| 2010-08-14 | Esmil Rogers | R | 25 | W 4-5 | vs MIL | 4 | 5 | - | 5.2 | 9 | 4 | 4 | 0 | 1 | 5 | 72 | 26 | 46 | 64% | 2-2 | 5.05 | 1.59 |
| 2010-08-15 | Ubaldo Jimenez | R | 27 | L 6-5 | vs MIL | 24 | 107 | - | 8.0 | 10 | 3 | 3 | 0 | 1 | 10 | 114 | 39 | 75 | 66% | 17-3 | 2.60 | 1.12 |
| 2010-08-17 | Jhoulys Chacin | R | 23 | L 0-6 | @ LAN | 13 | 14 | L | 5.0 | 5 | 5 | 5 | 0 | 5 | 4 | 100 | 47 | 53 | 53% | 5-9 | 4.34 | 1.36 |
| 2010-08-18 | Jason Hammel | R | 28 | W 3-2 | @ LAN | 22 | 80 | - | 6.0 | 4 | 2 | 2 | 0 | 4 | 4 | 117 | 49 | 68 | 58% | 8-7 | 4.37 | 1.30 |
| 2010-08-19 | Jorge De La Rosa | L | 29 | L 0-2 | @ LAN | 12 | 108 | L | 7.0 | 5 | 2 | 2 | 1 | 4 | 3 | 104 | 41 | 63 | 61% | 4-4 | 4.76 | 1.47 |
| 2010-08-20 | Esmil Rogers | R | 25 | L 3-4 | @ ARI | 5 | 6 | - | 6.1 | 6 | 1 | 1 | 0 | 1 | 6 | 101 | 43 | 58 | 57% | 2-2 | 4.50 | 1.50 |
| 2010-08-21 | Ubaldo Jimenez | R | 27 | L 1-3 | @ ARI | 25 | 108 | L | 6.0 | 3 | 3 | 3 | 1 | 1 | 3 | 105 | 43 | 62 | 59% | 17-4 | 2.66 | 1.11 |
| 2010-08-22 | Jhoulys Chacin | R | 23 | W 1-0 | @ ARI | 14 | 15 | W | 7.2 | 3 | 0 | 0 | 0 | 1 | 9 | 100 | 36 | 64 | 64% | 6-9 | 3.98 | 1.28 |
| 2010-08-23 | Jason Hammel | R | 28 | L 5-4 | vs ATL | 23 | 81 | - | 6.1 | 9 | 3 | 3 | 2 | 0 | 6 | 113 | 31 | 82 | 73% | 8-7 | 4.34 | 1.30 |
| 2010-08-24 | Jorge De La Rosa | L | 29 | L 5-2 | vs ATL | 13 | 109 | W | 7.0 | 6 | 2 | 2 | 1 | 1 | 7 | 90 | 25 | 65 | 72% | 5-4 | 4.56 | 1.43 |
| 2010-08-25 | Esmil Rogers | R | 25 | L 12-10 | vs ATL | 6 | 7 | - | 1.2 | 8 | 7 | 7 | 0 | 1 | 3 | 51 | 24 | 27 | 53% | 2-2 | 5.69 | 1.65 |
| 2010-08-27 | Ubaldo Jimenez | R | 27 | W 2-6 | vs LAN | 26 | 109 | L | 7.0 | 9 | 3 | 3 | 0 | 3 | 4 | 126 | 52 | 74 | 59% | 17-5 | 2.71 | 1.13 |
| 2010-08-28 | Jhoulys Chacin | R | 23 | L 5-3 | vs LAN | 15 | 16 | W | 7.0 | 4 | 1 | 1 | 0 | 4 | 7 | 101 | 47 | 54 | 53% | 7-9 | 3.79 | 1.27 |
| 2010-08-29 | Jason Hammel | R | 28 | L 10-5 | vs LAN | 24 | 82 | W | 5.1 | 7 | 2 | 2 | 0 | 3 | 7 | 112 | 45 | 67 | 60% | 9-7 | 4.32 | 1.32 |
| 2010-08-30 | Jorge De La Rosa | L | 29 | W 2-1 | @ SFN | 14 | 110 | - | 7.0 | 4 | 1 | 1 | 0 | 4 | 9 | 108 | 45 | 63 | 58% | 5-4 | 4.28 | 1.40 |
| 2010-08-31 | Esmil Rogers | R | 25 | L 2-5 | @ SFN | 7 | 8 | - | 6.0 | 4 | 2 | 2 | 0 | 2 | 3 | 78 | 34 | 44 | 56% | 2-2 | 5.40 | 1.58 |
| 2010-09-01 | Ubaldo Jimenez | R | 27 | L 1-2 | @ SFN | 27 | 110 | L | 8.0 | 4 | 2 | 2 | 0 | 3 | 10 | 115 | 50 | 65 | 57% | 17-6 | 2.69 | 1.12 |
| 2010-09-02 | Jhoulys Chacin | R | 23 | W 11-12 | vs PHI | 16 | 17 | - | 5.1 | 5 | 3 | 1 | 0 | 2 | 3 | 100 | 39 | 61 | 61% | 7-9 | 3.70 | 1.28 |
| 2010-09-03 | Aaron Cook | R | 32 | W 4-3 | @ SDN | 22 | 188 | W | 6.1 | 4 | 2 | 2 | 0 | 4 | 3 | 86 | 36 | 50 | 58% | 5-8 | 5.20 | 1.56 |
| 2010-09-04 | Jason Hammel | R | 28 | W 6-2 | @ SDN | 25 | 83 | W | 6.2 | 6 | 2 | 2 | 0 | 1 | 3 | 91 | 32 | 59 | 65% | 10-7 | 4.24 | 1.31 |
| 2010-09-05 | Jorge De La Rosa | L | 29 | W 4-2 | @ SDN | 15 | 111 | W | 6.0 | 6 | 2 | 2 | 1 | 2 | 4 | 101 | 40 | 61 | 60% | 6-4 | 4.19 | 1.40 |
| 2010-09-06 | Ubaldo Jimenez | R | 27 | L 10-5 | vs CIN | 28 | 111 | W | 6.0 | 7 | 4 | 4 | 0 | 6 | 8 | 122 | 50 | 72 | 59% | 18-6 | 2.79 | 1.15 |
| 2010-09-07 | Jhoulys Chacin | R | 23 | L 4-3 | vs CIN | 17 | 18 | W | 6.0 | 6 | 2 | 2 | 0 | 1 | 5 | 107 | 35 | 72 | 67% | 8-9 | 3.66 | 1.27 |
| 2010-09-08 | Aaron Cook | R | 32 | L 9-2 | vs CIN | 23 | 189 | W | 5.0 | 6 | 1 | 1 | 0 | 1 | 4 | 60 | 17 | 43 | 72% | 6-8 | 5.06 | 1.55 |
| 2010-09-09 | Jason Hammel | R | 28 | L 6-5 | vs CIN | 26 | 84 | - | 7.0 | 8 | 5 | 5 | 1 | 1 | 6 | 104 | 33 | 71 | 68% | 10-7 | 4.33 | 1.31 |
| 2010-09-10 | Jorge De La Rosa | L | 29 | L 13-4 | vs ARI | 16 | 112 | W | 6.0 | 5 | 2 | 2 | 1 | 0 | 10 | 103 | 35 | 68 | 66% | 7-4 | 4.12 | 1.36 |
| 2010-09-11 | Ubaldo Jimenez | R | 27 | L 2-1 | vs ARI | 29 | 112 | - | 6.0 | 6 | 1 | 1 | 0 | 1 | 8 | 113 | 42 | 71 | 63% | 18-6 | 2.76 | 1.15 |
| 2010-09-12 | Jhoulys Chacin | R | 23 | L 4-2 | vs ARI | 18 | 19 | - | 4.0 | 5 | 2 | 0 | 0 | 4 | 4 | 84 | 38 | 46 | 55% | 8-9 | 3.54 | 1.31 |
| 2010-09-13 | Jeff Francis | L | 30 | W 4-6 | vs SDN | 17 | 147 | L | 3.0 | 5 | 2 | 2 | 1 | 0 | 2 | 62 | 21 | 41 | 66% | 4-5 | 4.59 | 1.28 |
| 2010-09-14 | Jason Hammel | R | 28 | W 6-7 | vs SDN | 27 | 85 | L | 4.0 | 10 | 4 | 4 | 0 | 2 | 3 | 58 | 21 | 37 | 64% | 10-8 | 4.45 | 1.35 |
| 2010-09-15 | Jorge De La Rosa | L | 29 | L 9-6 | vs SDN | 17 | 113 | W | 7.1 | 6 | 5 | 5 | 2 | 1 | 7 | 108 | 33 | 75 | 69% | 8-4 | 4.24 | 1.32 |
| 2010-09-17 | Ubaldo Jimenez | R | 27 | W 7-5 | @ LAN | 30 | 113 | W | 6.1 | 6 | 4 | 4 | 0 | 3 | 6 | 110 | 44 | 66 | 60% | 19-6 | 2.84 | 1.16 |
| 2010-09-18 | Jhoulys Chacin | R | 23 | W 12-2 | @ LAN | 19 | 20 | W | 8.0 | 9 | 0 | 0 | 0 | 0 | 2 | 117 | 45 | 72 | 62% | 9-9 | 3.31 | 1.30 |
| 2010-09-19 | Jason Hammel | R | 28 | L 6-7 | @ LAN | 28 | 86 | - | 4.0 | 6 | 4 | 4 | 1 | 1 | 2 | 80 | 24 | 56 | 70% | 10-8 | 4.55 | 1.36 |
| 2010-09-21 | Jorge De La Rosa | L | 29 | L 1-3 | @ ARI | 18 | 114 | L | 7.0 | 6 | 3 | 3 | 1 | 1 | 5 | 127 | 53 | 74 | 58% | 8-5 | 4.21 | 1.30 |
| 2010-09-22 | Ubaldo Jimenez | R | 27 | L 4-8 | @ ARI | 31 | 114 | L | 4.0 | 5 | 5 | 5 | 2 | 4 | 6 | 98 | 47 | 51 | 52% | 19-7 | 3.00 | 1.18 |
| 2010-09-23 | Jeff Francis | L | 30 | L 9-10 | @ ARI | 18 | 148 | L | 3.2 | 6 | 3 | 3 | 1 | 3 | 4 | 80 | 30 | 50 | 63% | 4-6 | 4.73 | 1.33 |
| 2010-09-24 | Jhoulys Chacin | R | 23 | W 1-2 | vs SFN | 20 | 21 | L | 7.0 | 3 | 2 | 2 | 1 | 3 | 8 | 120 | 50 | 70 | 58% | 9-10 | 3.27 | 1.27 |
| 2010-09-25 | Jason Hammel | R | 28 | L 10-9 | vs SFN | 29 | 87 | - | 5.0 | 8 | 4 | 4 | 3 | 1 | 3 | 89 | 32 | 57 | 64% | 10-8 | 4.63 | 1.37 |
| 2010-09-26 | Jorge De La Rosa | L | 29 | W 2-4 | vs SFN | 19 | 115 | L | 6.0 | 4 | 3 | 3 | 1 | 5 | 4 | 100 | 42 | 58 | 58% | 8-6 | 4.23 | 1.31 |
| 2010-09-27 | Ubaldo Jimenez | R | 27 | W 1-3 | vs LAN | 32 | 115 | L | 7.0 | 3 | 2 | 2 | 0 | 4 | 6 | 122 | 47 | 75 | 61% | 19-8 | 2.99 | 1.17 |
| 2010-09-28 | Jeff Francis | L | 30 | W 7-9 | vs LAN | 19 | 149 | - | 3.0 | 6 | 5 | 4 | 2 | 0 | 1 | 61 | 19 | 42 | 69% | 4-6 | 4.94 | 1.35 |
| 2010-09-29 | Jhoulys Chacin | R | 23 | W 6-7 | vs LAN | 21 | 22 | L | 5.0 | 4 | 7 | 2 | 1 | 3 | 7 | 89 | 35 | 54 | 61% | 9-11 | 3.28 | 1.28 |
| 2010-09-30 | Jason Hammel | R | 28 | L 1-6 | @ SLN | 30 | 88 | L | 3.0 | 8 | 5 | 5 | 0 | 0 | 1 | 56 | 16 | 40 | 71% | 10-9 | 4.80 | 1.39 |
| 2010-10-01 | Jorge De La Rosa | L | 29 | L 0-3 | @ SLN | 20 | 116 | L | 7.0 | 5 | 3 | 3 | 0 | 4 | 1 | 110 | 49 | 61 | 55% | 8-7 | 4.20 | 1.31 |
| 2010-10-02 | Ubaldo Jimenez | R | 27 | L 0-1 | @ SLN | 33 | 116 | - | 8.0 | 3 | 0 | 0 | 0 | 2 | 10 | 116 | 39 | 77 | 66% | 19-8 | 2.88 | 1.15 |
| 2010-10-03 | Esmil Rogers | R | 25 | L 1-6 | @ SLN | 8 | 9 | L | 4.0 | 7 | 4 | 2 | 0 | 1 | 2 | 74 | 32 | 42 | 57% | 2-3 | 6.13 | 1.67 |