| 2010-04-05 | @ MIL | 1 | W 5-3 | 1-0 | 2 | 45,808 | Ubaldo Jimenez | Yovani Gallardo | Ubaldo Jimenez | Yovani Gallardo | Franklin Morales | 5 | 3 | 2 |
| 2010-04-06 | @ MIL | 2 | L 5-7 | 1-1 | 4 | 37,344 | Greg Smith | Randy Wolf | Randy Wolf | Greg Smith | Trevor Hoffman | 10 | 10 | 0 |
| 2010-04-07 | @ MIL | 3 | L 4-5 | 1-2 | 4 | 35,793 | Aaron Cook | Doug Davis | Todd Coffey | Aaron Cook | Trevor Hoffman | 14 | 15 | -1 |
| 2010-04-09 | vs SDN | 4 | W 7-0 | 2-2 | 3 | 49,509 | Jorge de la Rosa | Clayton Richard | Jorge de la Rosa | Clayton Richard | | 21 | 15 | 6 |
| 2010-04-10 | vs SDN | 5 | L 4-5 | 2-3 | 3 | 36,090 | Jason Hammel | Mat Latos | Tim Stauffer | Manuel Corpas | Heath Bell | 25 | 20 | 5 |
| 2010-04-11 | vs SDN | 6 | W 4-2 | 3-3 | 3 | 39,576 | Ubaldo Jimenez | Jon Garland | Ubaldo Jimenez | Jon Garland | Franklin Morales | 29 | 22 | 7 |
| 2010-04-13 | vs NYN | 7 | W 11-3 | 3-4 | 3 | 25,110 | Greg Smith | John Maine | Greg Smith | John Maine | | 40 | 25 | 15 |
| 2010-04-14 | vs NYN | 8 | W 6-5 | 4-4 | 3 | 26,310 | Aaron Cook | Jonathon Niese | Randy Flores | Jenrry Mejia | | 46 | 30 | 16 |
| 2010-04-15 | vs NYN | 9 | L 0-5 | 4-5 | 3 | 26,195 | Jorge de la Rosa | Mike Pelfrey | Mike Pelfrey | Jorge de la Rosa | | 46 | 35 | 11 |
| 2010-04-16 | @ ATL | 10 | L 5-9 | 4-6 | 3 | 27,692 | Jason Hammel | Derek Lowe | Derek Lowe | Jason Hammel | | 51 | 44 | 7 |
| 2010-04-17 | @ ATL | 11 | W 4-0 | 5-6 | 2 | 32,602 | Ubaldo Jimenez | Kenshin Kawakami | Ubaldo Jimenez | Kenshin Kawakami | | 55 | 44 | 11 |
| 2010-04-18 | @ ATL | 12 | L 3-4 | 5-7 | 2 | 26,546 | Greg Smith | Jair Jurrjens | Eric O'Flaherty | Franklin Morales | | 58 | 48 | 10 |
| 2010-04-19 | @ WAS | 13 | L 2-5 | 5-8 | 4 | 11,623 | Aaron Cook | Craig Stammen | Craig Stammen | Aaron Cook | Matt Capps | 60 | 53 | 7 |
| 2010-04-20 | @ WAS | 14 | W 10-4 | 5-9 | 5 | 15,037 | Jorge de la Rosa | Scott Olsen | Jorge de la Rosa | Scott Olsen | | 70 | 57 | 13 |
| 2010-04-21 | @ WAS | 15 | L 4-6 | 5-10 | 5 | 11,191 | Jason Hammel | John Lannan | Tyler Clippard | Rafael Betancourt | Matt Capps | 74 | 63 | 11 |
| 2010-04-22 | @ WAS | 16 | W 2-0 | 6-10 | 4 | 15,518 | Ubaldo Jimenez | Livan Hernandez | Ubaldo Jimenez | Livan Hernandez | Franklin Morales | 76 | 63 | 13 |
| 2010-04-24 | vs FLO | 17 | L 1-4 | 6-11 | 6 | 0 | Greg Smith | Ricky Nolasco | Ricky Nolasco | Greg Smith | Leo Nunez | 77 | 67 | 10 |
| 2010-04-24 | vs FLO | 18 | W 8-1 | 6-11 | 6 | 31,560 | Aaron Cook | Nate Robertson | Aaron Cook | Nate Robertson | | 85 | 68 | 17 |
| 2010-04-25 | vs FLO | 19 | W 8-4 | 8-11 | 3 | 35,883 | Jorge de la Rosa | Chris Volstad | Jorge de la Rosa | Chris Volstad | | 93 | 72 | 21 |
| 2010-04-26 | vs ARI | 20 | L 3-5 | 8-12 | 4 | 20,308 | Jason Hammel | Dan Haren | Dan Haren | Jason Hammel | Chad Qualls | 96 | 77 | 19 |
| 2010-04-27 | vs ARI | 21 | W 12-1 | 9-12 | 3 | 24,112 | Ubaldo Jimenez | Edwin Jackson | Ubaldo Jimenez | Edwin Jackson | | 108 | 78 | 30 |
| 2010-04-28 | vs ARI | 22 | L 11-12 | 9-13 | 4 | 23,773 | Greg Smith | Kris Benson | Bob Howry | Franklin Morales | Juan Gutierrez | 119 | 90 | 29 |
| 2010-04-30 | @ SFN | 23 | L 2-5 | 9-14 | 4 | 37,144 | Aaron Cook | Barry Zito | Barry Zito | Aaron Cook | Jeremy Affeldt | 121 | 95 | 26 |
| 2010-05-01 | @ SFN | 24 | L 1-6 | 9-15 | 5 | 39,211 | Esmil Rogers | Matt Cain | Matt Cain | Esmil Rogers | | 122 | 101 | 21 |
| 2010-05-02 | @ SFN | 25 | W 4-1 | 10-15 | 5 | 41,831 | Jhoulis Chacin | Jonathan Sanchez | Jhoulis Chacin | Jonathan Sanchez | | 126 | 102 | 24 |
| 2010-05-03 | @ SDN | 26 | W 5-2 | 11-15 | 5 | 15,052 | Ubaldo Jimenez | Kevin Correia | Ubaldo Jimenez | Kevin Correia | | 131 | 104 | 27 |
| 2010-05-04 | @ SDN | 27 | L 2-3 | 11-16 | 5 | 16,329 | Greg Smith | Wade LeBlanc | Heath Bell | Franklin Morales | | 133 | 107 | 26 |
| 2010-05-05 | @ SDN | 28 | W 6-5 | 12-16 | 5 | 17,121 | Aaron Cook | Clayton Richard | Manuel Corpas | Tim Stauffer | | 139 | 112 | 27 |
| 2010-05-07 | @ LAN | 29 | L 5-6 | 12-17 | 5 | 40,567 | Esmil Rogers | Hiroki Kuroda | Jeff Weaver | Matt Daley | Jonathan Broxton | 144 | 118 | 26 |
| 2010-05-08 | @ LAN | 30 | W 8-0 | 13-17 | 5 | 42,287 | Jhoulis Chacin | Charlie Haeger | Jhoulis Chacin | Charlie Haeger | | 152 | 118 | 34 |
| 2010-05-09 | @ LAN | 31 | L 0-2 | 13-18 | 5 | 40,718 | Ubaldo Jimenez | Clayton Kershaw | Clayton Kershaw | Ubaldo Jimenez | Jonathan Broxton | 152 | 120 | 32 |
| 2010-05-10 | vs PHI | 32 | L 5-9 | 13-19 | 5 | 30,403 | Greg Smith | Kyle Kendrick | Danys Baez | Manuel Corpas | | 157 | 129 | 28 |
| 2010-05-12 | vs PHI | 33 | W 4-3 | 14-19 | 5 | 23,475 | Aaron Cook | Roy Halladay | Joe Beimel | Chad Durbin | | 161 | 132 | 29 |
| 2010-05-13 | vs WAS | 34 | L 6-14 | 15-19 | 5 | 20,795 | Jhoulis Chacin | John Lannan | Doug Slaten | Jhoulis Chacin | | 167 | 146 | 21 |
| 2010-05-15 | vs WAS | 35 | W 6-2 | 16-19 | 6 | 29,111 | Ubaldo Jimenez | Livan Hernandez | Ubaldo Jimenez | Livan Hernandez | | 173 | 148 | 25 |
| 2010-05-15 | vs WAS | 36 | W 4-3 | 16-19 | 6 | 35,258 | Jason Hammel | Luis Atilano | Jason Hammel | Sean Burnett | Manuel Corpas | 177 | 151 | 26 |
| 2010-05-16 | vs WAS | 37 | W 2-1 | 18-19 | 4 | 42,874 | Jeff Francis | Scott Olsen | Matt Belisle | Tyler Clippard | Manuel Corpas | 179 | 152 | 27 |
| 2010-05-17 | @ CHN | 38 | L 2-4 | 18-20 | 4 | 35,760 | Aaron Cook | Randy Wells | Sean Marshall | Matt Belisle | | 181 | 156 | 25 |
| 2010-05-18 | @ CHN | 39 | L 2-6 | 18-21 | 4 | 37,029 | Jhoulis Chacin | Carlos Silva | Carlos Silva | Jhoulis Chacin | | 183 | 162 | 21 |
| 2010-05-19 | @ HOU | 40 | L 3-7 | 18-22 | 5 | 25,200 | Greg Smith | Felipe Paulino | Brandon Lyon | Esmil Rogers | | 186 | 169 | 17 |
| 2010-05-20 | @ HOU | 41 | W 4-0 | 19-22 | 5 | 25,932 | Ubaldo Jimenez | Roy Oswalt | Ubaldo Jimenez | Roy Oswalt | | 190 | 169 | 21 |
| 2010-05-21 | @ KCA | 42 | L 2-9 | 19-23 | 5 | 24,807 | Jason Hammel | Brian Bannister | Brian Bannister | Jason Hammel | | 192 | 178 | 14 |
| 2010-05-22 | @ KCA | 43 | W 3-0 | 20-23 | 5 | 20,907 | Jeff Francis | Kyle Davies | Jeff Francis | Kyle Davies | Manuel Corpas | 195 | 178 | 17 |
| 2010-05-23 | @ KCA | 44 | W 11-7 | 20-24 | 5 | 21,876 | Aaron Cook | Zack Greinke | Esmil Rogers | Zack Greinke | | 206 | 185 | 21 |
| 2010-05-25 | vs ARI | 45 | W 3-2 | 21-24 | 5 | 28,370 | Jhoulis Chacin | Ian Kennedy | Jhoulis Chacin | Ian Kennedy | Manuel Corpas | 209 | 187 | 22 |
| 2010-05-26 | vs ARI | 46 | W 7-3 | 22-24 | 5 | 26,320 | Ubaldo Jimenez | Rodrigo Lopez | Ubaldo Jimenez | Rodrigo Lopez | | 216 | 190 | 26 |
| 2010-05-27 | vs ARI | 47 | W 8-2 | 23-24 | 4 | 28,353 | Jason Hammel | Dan Haren | Jason Hammel | Dan Haren | | 224 | 192 | 32 |
| 2010-05-28 | vs LAN | 48 | L 4-5 | 23-25 | 4 | 40,162 | Jeff Francis | Carlos Monasterios | Carlos Monasterios | Jeff Francis | Jonathan Broxton | 228 | 197 | 31 |
| 2010-05-29 | vs LAN | 49 | W 11-3 | 23-26 | 4 | 43,261 | Aaron Cook | Hiroki Kuroda | Aaron Cook | Hiroki Kuroda | | 239 | 200 | 39 |
| 2010-05-30 | vs LAN | 50 | L 3-4 | 23-27 | 4 | 48,682 | Jhoulis Chacin | Clayton Kershaw | Clayton Kershaw | Jhoulis Chacin | Jonathan Broxton | 242 | 204 | 38 |
| 2010-05-31 | @ SFN | 51 | W 4-0 | 24-27 | 4 | 42,465 | Ubaldo Jimenez | Tim Lincecum | Ubaldo Jimenez | Tim Lincecum | | 246 | 204 | 42 |
| 2010-06-01 | @ SFN | 52 | W 2-1 | 25-27 | 4 | 31,198 | Jason Hammel | Barry Zito | Rafael Betancourt | Santiago Casilla | Manuel Corpas | 248 | 205 | 43 |
| 2010-06-02 | @ SFN | 53 | L 1-4 | 25-28 | 4 | 30,697 | Jeff Francis | Matt Cain | Matt Cain | Jeff Francis | Brian Wilson | 249 | 209 | 40 |
| 2010-06-04 | @ ARI | 54 | L 6-7 | 25-29 | 4 | 25,290 | Aaron Cook | Ian Kennedy | Chad Qualls | Manuel Corpas | | 255 | 216 | 39 |
| 2010-06-05 | @ ARI | 55 | L 3-4 | 25-30 | 4 | 28,138 | Jhoulis Chacin | Dontrelle Willis | Dontrelle Willis | Jhoulis Chacin | Chad Qualls | 258 | 220 | 38 |
| 2010-06-06 | @ ARI | 56 | W 3-2 | 26-30 | 4 | 20,793 | Ubaldo Jimenez | Rodrigo Lopez | Ubaldo Jimenez | Rodrigo Lopez | Manuel Corpas | 261 | 222 | 39 |
| 2010-06-07 | vs HOU | 57 | W 5-1 | 27-30 | 4 | 28,251 | Jason Hammel | Wandy Rodriguez | Jason Hammel | Wandy Rodriguez | Manuel Corpas | 266 | 223 | 43 |
| 2010-06-08 | vs HOU | 58 | L 3-4 | 27-31 | 4 | 26,201 | Jeff Francis | Brian Moehler | Wilton Lopez | Matt Belisle | Matt Lindstrom | 269 | 227 | 42 |
| 2010-06-09 | vs HOU | 59 | L 2-6 | 27-32 | 4 | 27,114 | Aaron Cook | Felipe Paulino | Brandon Lyon | Matt Belisle | | 271 | 233 | 38 |
| 2010-06-10 | vs HOU | 60 | L 4-5 | 27-33 | 6 | 28,329 | Jhoulis Chacin | Roy Oswalt | Roy Oswalt | Jhoulis Chacin | Brandon Lyon | 275 | 238 | 37 |
| 2010-06-11 | vs TOR | 61 | W 5-3 | 28-33 | 4 | 31,101 | Ubaldo Jimenez | Ricky Romero | Ubaldo Jimenez | Ricky Romero | | 280 | 241 | 39 |
| 2010-06-12 | vs TOR | 62 | W 1-0 | 29-33 | 4 | 26,304 | Jason Hammel | Brandon Morrow | Jason Hammel | Brandon Morrow | Manuel Corpas | 281 | 241 | 40 |
| 2010-06-13 | vs TOR | 63 | W 10-3 | 29-34 | 5 | 32,084 | Jeff Francis | Jesse Litsch | Jeff Francis | Jesse Litsch | | 291 | 244 | 47 |
| 2010-06-15 | @ MIN | 64 | L 3-9 | 29-35 | 5 | 39,812 | Aaron Cook | Carl Pavano | Carl Pavano | Aaron Cook | | 294 | 253 | 41 |
| 2010-06-16 | @ MIN | 65 | L 1-2 | 29-36 | 5 | 40,814 | Jhoulis Chacin | Scott Baker | Scott Baker | Jhoulis Chacin | Jon Rauch | 295 | 255 | 40 |
| 2010-06-17 | @ MIN | 66 | W 5-1 | 30-36 | 4 | 40,741 | Ubaldo Jimenez | Francisco Liriano | Ubaldo Jimenez | Francisco Liriano | | 300 | 256 | 44 |
| 2010-06-18 | vs MIL | 67 | W 2-0 | 31-36 | 4 | 32,340 | Jason Hammel | Manny Parra | Jason Hammel | Manny Parra | Manuel Corpas | 302 | 256 | 46 |
| 2010-06-19 | vs MIL | 68 | W 8-7 | 32-36 | 4 | 39,192 | Jeff Francis | Yovani Gallardo | Matt Belisle | Zach Braddock | Rafael Betancourt | 310 | 263 | 47 |
| 2010-06-20 | vs MIL | 69 | L 1-6 | 32-37 | 4 | 46,511 | Aaron Cook | Randy Wolf | Trevor Hoffman | Manuel Corpas | | 311 | 269 | 42 |
| 2010-06-22 | vs BOS | 70 | W 2-1 | 33-37 | 4 | 48,112 | Jhoulis Chacin | Jon Lester | Jhoulis Chacin | Jon Lester | Matt Belisle | 313 | 270 | 43 |
| 2010-06-23 | vs BOS | 71 | W 8-6 | 34-37 | 4 | 48,243 | Ubaldo Jimenez | John Lackey | Manuel Corpas | Jonathan Papelbon | | 321 | 276 | 45 |
| 2010-06-24 | vs BOS | 72 | L 11-13 | 34-38 | 4 | 48,582 | Jason Hammel | Daisuke Matsuzaka | Jonathan Papelbon | Huston Street | | 332 | 289 | 43 |
| 2010-06-25 | @ ANA | 73 | W 4-3 | 35-38 | 4 | 37,228 | Jeff Francis | Jered Weaver | Matt Belisle | Francisco Rodriguez | Manuel Corpas | 336 | 292 | 44 |
| 2010-06-26 | @ ANA | 74 | L 2-4 | 35-39 | 4 | 39,225 | Aaron Cook | Joe Saunders | Joe Saunders | Aaron Cook | Brian Fuentes | 338 | 296 | 42 |
| 2010-06-27 | @ ANA | 75 | L 3-10 | 36-39 | 4 | 37,314 | Jhoulis Chacin | Ervin Santana | Ervin Santana | Jhoulis Chacin | | 341 | 306 | 35 |
| 2010-06-28 | @ SDN | 76 | W 10-6 | 36-40 | 4 | 21,018 | Ubaldo Jimenez | Kevin Correia | Ubaldo Jimenez | Kevin Correia | | 351 | 312 | 39 |
| 2010-06-29 | @ SDN | 77 | W 6-3 | 37-40 | 4 | 21,196 | Jason Hammel | Wade LeBlanc | Jason Hammel | Wade LeBlanc | Huston Street | 357 | 315 | 42 |
| 2010-06-30 | @ SDN | 78 | L 3-13 | 38-40 | 4 | 24,519 | Jeff Francis | Clayton Richard | Clayton Richard | Jeff Francis | | 360 | 328 | 32 |
| 2010-07-01 | vs SFN | 79 | W 7-3 | 39-40 | 4 | 32,134 | Aaron Cook | Madison Bumgarner | Aaron Cook | Madison Bumgarner | | 367 | 331 | 36 |
| 2010-07-02 | vs SFN | 80 | W 6-3 | 40-40 | 3 | 48,127 | Jhoulis Chacin | Tim Lincecum | Jhoulis Chacin | Tim Lincecum | Huston Street | 373 | 334 | 39 |
| 2010-07-03 | vs SFN | 81 | L 8-11 | 41-40 | 3 | 49,271 | Ubaldo Jimenez | Barry Zito | Denny Bautista | Manuel Corpas | Brian Wilson | 381 | 345 | 36 |
| 2010-07-04 | vs SFN | 82 | W 4-3 | 42-40 | 3 | 35,274 | Jason Hammel | Matt Cain | Randy Flores | Guillermo Mota | | 385 | 348 | 37 |
| 2010-07-06 | vs SLN | 83 | W 12-9 | 42-41 | 3 | 32,922 | Jeff Francis | Blake Hawksworth | Manuel Corpas | Ryan Franklin | | 397 | 357 | 40 |
| 2010-07-07 | vs SLN | 84 | W 8-7 | 43-41 | 3 | 33,251 | Aaron Cook | Jaime Garcia | Huston Street | Evan MacLane | | 405 | 364 | 41 |
| 2010-07-08 | vs SLN | 85 | W 4-2 | 44-41 | 3 | 37,456 | Ubaldo Jimenez | Chris Carpenter | Ubaldo Jimenez | Chris Carpenter | Huston Street | 409 | 366 | 43 |
| 2010-07-09 | vs SDN | 86 | W 10-8 | 44-42 | 3 | 36,123 | Jorge de la Rosa | Kevin Correia | Matt Belisle | Luke Gregerson | Huston Street | 419 | 374 | 45 |
| 2010-07-10 | vs SDN | 87 | W 4-2 | 45-42 | 3 | 45,069 | Jason Hammel | Wade LeBlanc | Jason Hammel | Wade LeBlanc | Huston Street | 423 | 376 | 47 |
| 2010-07-11 | vs SDN | 88 | L 7-9 | 45-43 | 3 | 40,460 | Jeff Francis | Clayton Richard | Luke Gregerson | Matt Belisle | Heath Bell | 430 | 385 | 45 |
| 2010-07-16 | @ CIN | 89 | L 2-3 | 45-44 | 3 | 37,188 | Jason Hammel | Bronson Arroyo | Bronson Arroyo | Jason Hammel | Francisco Cordero | 432 | 388 | 44 |
| 2010-07-17 | @ CIN | 90 | L 1-8 | 45-45 | 4 | 41,300 | Jorge de la Rosa | Edinson Volquez | Edinson Volquez | Jorge de la Rosa | | 433 | 396 | 37 |
| 2010-07-18 | @ CIN | 91 | W 1-0 | 46-45 | 3 | 25,159 | Aaron Cook | Travis Wood | Aaron Cook | Travis Wood | Huston Street | 434 | 396 | 38 |
| 2010-07-19 | @ FLO | 92 | L 8-9 | 46-46 | 4 | 16,144 | Ubaldo Jimenez | Anibal Sanchez | Jhan Marinez | Huston Street | | 442 | 405 | 37 |
| 2010-07-20 | @ FLO | 93 | W 10-0 | 47-46 | 4 | 16,012 | Jeff Francis | Nate Robertson | Jeff Francis | Nate Robertson | | 452 | 405 | 47 |
| 2010-07-21 | @ FLO | 94 | L 2-5 | 47-47 | 4 | 18,332 | Jason Hammel | Ricky Nolasco | Ricky Nolasco | Jason Hammel | Leo Nunez | 454 | 410 | 44 |
| 2010-07-22 | @ FLO | 95 | L 2-3 | 47-48 | 4 | 29,102 | Jorge de la Rosa | Josh Johnson | Leo Nunez | Jhoulis Chacin | | 456 | 413 | 43 |
| 2010-07-23 | @ PHI | 96 | L 0-6 | 47-49 | 4 | 45,265 | Aaron Cook | Roy Halladay | Roy Halladay | Aaron Cook | | 456 | 419 | 37 |
| 2010-07-24 | @ PHI | 97 | L 2-10 | 48-49 | 4 | 44,781 | Ubaldo Jimenez | Kyle Kendrick | Kyle Kendrick | Ubaldo Jimenez | | 458 | 429 | 29 |
| 2010-07-25 | @ PHI | 98 | L 3-4 | 48-50 | 4 | 44,726 | Jeff Francis | J.A. Happ | Ryan Madson | Joe Beimel | Brad Lidge | 461 | 433 | 28 |
| 2010-07-26 | @ PHI | 99 | L 4-5 | 48-51 | 4 | 44,838 | Jason Hammel | Joe Blanton | Joe Blanton | Jason Hammel | Brad Lidge | 465 | 438 | 27 |
| 2010-07-27 | vs PIT | 100 | L 2-4 | 48-52 | 4 | 46,608 | Jorge de la Rosa | Zach Duke | Zach Duke | Jorge de la Rosa | Octavio Dotel | 467 | 442 | 25 |
| 2010-07-28 | vs PIT | 101 | L 2-6 | 48-53 | 4 | 35,128 | Aaron Cook | Ross Ohlendorf | Sean Gallagher | Aaron Cook | | 469 | 448 | 21 |
| 2010-07-29 | vs PIT | 102 | W 9-3 | 49-53 | 4 | 34,158 | Ubaldo Jimenez | Paul Maholm | Ubaldo Jimenez | Paul Maholm | | 478 | 451 | 27 |
| 2010-07-30 | vs CHN | 103 | W 17-2 | 49-54 | 4 | 40,189 | Jeff Francis | Ryan Dempster | Jeff Francis | Ryan Dempster | | 495 | 453 | 42 |
| 2010-07-31 | vs CHN | 104 | W 6-5 | 50-54 | 4 | 48,065 | Jason Hammel | Tom Gorzelanny | Huston Street | Sean Marshall | | 501 | 458 | 43 |
| 2010-08-01 | vs CHN | 105 | W 8-7 | 51-54 | 4 | 38,256 | Jorge de la Rosa | Carlos Silva | Jorge de la Rosa | Carlos Silva | | 509 | 465 | 44 |
| 2010-08-03 | vs SFN | 106 | L 0-10 | 51-55 | 4 | 43,549 | Aaron Cook | Jonathan Sanchez | Jonathan Sanchez | Aaron Cook | | 509 | 475 | 34 |
| 2010-08-04 | vs SFN | 107 | W 6-1 | 52-55 | 4 | 37,278 | Ubaldo Jimenez | Madison Bumgarner | Ubaldo Jimenez | Madison Bumgarner | | 515 | 476 | 39 |
| 2010-08-05 | @ PIT | 108 | L 1-5 | 52-56 | 4 | 17,131 | Jeff Francis | James McDonald | James McDonald | Jeff Francis | | 516 | 481 | 35 |
| 2010-08-06 | @ PIT | 109 | W 6-3 | 53-56 | 4 | 30,711 | Jason Hammel | Zach Duke | Jason Hammel | Chan Ho Park | Huston Street | 522 | 484 | 38 |
| 2010-08-07 | @ PIT | 110 | L 7-8 | 53-57 | 4 | 38,147 | Jorge de la Rosa | Ross Ohlendorf | Sean Gallagher | Huston Street | | 529 | 492 | 37 |
| 2010-08-08 | @ PIT | 111 | W 8-4 | 54-57 | 4 | 22,716 | Esmil Rogers | Paul Maholm | Esmil Rogers | Paul Maholm | | 537 | 496 | 41 |
| 2010-08-10 | @ NYN | 112 | L 0-1 | 54-58 | 4 | 30,036 | Ubaldo Jimenez | Mike Pelfrey | Mike Pelfrey | Ubaldo Jimenez | Francisco Rodriguez | 537 | 497 | 40 |
| 2010-08-11 | @ NYN | 113 | W 6-2 | 55-58 | 4 | 30,554 | Jeff Francis | Jonathon Niese | Matt Belisle | Hisanori Takahashi | | 543 | 499 | 44 |
| 2010-08-12 | @ NYN | 114 | L 0-4 | 55-59 | 4 | 32,272 | Jason Hammel | Johan Santana | Johan Santana | Jason Hammel | | 543 | 503 | 40 |
| 2010-08-13 | vs MIL | 115 | W 5-4 | 56-59 | 4 | 39,142 | Jorge de la Rosa | Yovani Gallardo | Taylor Buchholz | Kameron Loe | Huston Street | 548 | 507 | 41 |
| 2010-08-14 | vs MIL | 116 | L 4-5 | 56-60 | 4 | 45,264 | Esmil Rogers | Chris Narveson | John Axford | Huston Street | | 552 | 512 | 40 |
| 2010-08-15 | vs MIL | 117 | W 6-5 | 57-60 | 4 | 48,133 | Ubaldo Jimenez | Manny Parra | Rafael Betancourt | Trevor Hoffman | | 558 | 517 | 41 |
| 2010-08-17 | @ LAN | 118 | L 0-6 | 57-61 | 4 | 49,540 | Jhoulis Chacin | Clayton Kershaw | Clayton Kershaw | Jhoulis Chacin | | 558 | 523 | 35 |
| 2010-08-18 | @ LAN | 119 | W 3-2 | 58-61 | 4 | 44,268 | Jason Hammel | Hiroki Kuroda | Rafael Betancourt | Octavio Dotel | Huston Street | 561 | 525 | 36 |
| 2010-08-19 | @ LAN | 120 | L 0-2 | 58-62 | 4 | 45,104 | Jorge de la Rosa | Ted Lilly | Ted Lilly | Jorge de la Rosa | | 561 | 527 | 34 |
| 2010-08-20 | @ ARI | 121 | L 3-4 | 58-63 | 4 | 26,294 | Esmil Rogers | Ian Kennedy | Aaron Heilman | Joe Beimel | | 564 | 531 | 33 |
| 2010-08-21 | @ ARI | 122 | L 1-3 | 58-64 | 4 | 37,631 | Ubaldo Jimenez | Barry Enright | Barry Enright | Ubaldo Jimenez | Juan Gutierrez | 565 | 534 | 31 |
| 2010-08-22 | @ ARI | 123 | W 1-0 | 59-64 | 4 | 30,397 | Jhoulis Chacin | Daniel Hudson | Jhoulis Chacin | Aaron Heilman | Huston Street | 566 | 534 | 32 |
| 2010-08-23 | vs ATL | 124 | W 5-4 | 60-64 | 4 | 34,172 | Jason Hammel | Tim Hudson | Rafael Betancourt | Jonny Venters | Huston Street | 571 | 538 | 33 |
| 2010-08-24 | vs ATL | 125 | W 5-2 | 61-64 | 4 | 34,485 | Jorge de la Rosa | Derek Lowe | Jorge de la Rosa | Derek Lowe | Huston Street | 576 | 540 | 36 |
| 2010-08-25 | vs ATL | 126 | W 12-10 | 62-64 | 4 | 27,675 | Esmil Rogers | Jair Jurrjens | Matt Belisle | Jonny Venters | | 588 | 550 | 38 |
| 2010-08-27 | vs LAN | 127 | L 2-6 | 62-65 | 4 | 41,964 | Ubaldo Jimenez | Clayton Kershaw | Jonathan Broxton | Ubaldo Jimenez | Hong-Chih Kuo | 590 | 556 | 34 |
| 2010-08-28 | vs LAN | 128 | W 5-3 | 63-65 | 4 | 45,322 | Jhoulis Chacin | Chad Billingsley | Jhoulis Chacin | Chad Billingsley | | 595 | 559 | 36 |
| 2010-08-29 | vs LAN | 129 | W 10-5 | 63-66 | 4 | 38,343 | Jason Hammel | Ted Lilly | Jason Hammel | Ted Lilly | | 605 | 564 | 41 |
| 2010-08-30 | @ SFN | 130 | W 2-1 | 64-66 | 4 | 30,224 | Jorge de la Rosa | Jonathan Sanchez | Rafael Betancourt | Brian Wilson | Huston Street | 607 | 565 | 42 |
| 2010-08-31 | @ SFN | 131 | L 2-5 | 64-67 | 4 | 31,099 | Esmil Rogers | Madison Bumgarner | Jeremy Affeldt | Matt Belisle | Brian Wilson | 609 | 570 | 39 |
| 2010-09-01 | @ SFN | 132 | L 1-2 | 64-68 | 4 | 31,186 | Ubaldo Jimenez | Tim Lincecum | Tim Lincecum | Ubaldo Jimenez | Brian Wilson | 610 | 572 | 38 |
| 2010-09-02 | vs PHI | 133 | L 11-12 | 64-69 | 4 | 30,179 | Jhoulis Chacin | Joe Blanton | Antonio Bastardo | Manny Delcarmen | Brad Lidge | 621 | 584 | 37 |
| 2010-09-03 | @ SDN | 134 | W 4-3 | 65-69 | 4 | 21,877 | Aaron Cook | Cory Luebke | Aaron Cook | Cory Luebke | Huston Street | 625 | 587 | 38 |
| 2010-09-04 | @ SDN | 135 | W 6-2 | 66-69 | 4 | 26,168 | Jason Hammel | Jon Garland | Jason Hammel | Jon Garland | | 631 | 589 | 42 |
| 2010-09-05 | @ SDN | 136 | W 4-2 | 67-69 | 4 | 23,250 | Jorge de la Rosa | Clayton Richard | Jorge de la Rosa | Tim Stauffer | Huston Street | 635 | 591 | 44 |
| 2010-09-06 | vs CIN | 137 | W 10-5 | 67-70 | 4 | 40,237 | Ubaldo Jimenez | Aaron Harang | Ubaldo Jimenez | Bill Bray | | 645 | 596 | 49 |
| 2010-09-07 | vs CIN | 138 | W 4-3 | 68-70 | 4 | 29,164 | Jhoulis Chacin | Johnny Cueto | Jhoulis Chacin | Johnny Cueto | Huston Street | 649 | 599 | 50 |
| 2010-09-08 | vs CIN | 139 | W 9-2 | 69-70 | 4 | 28,271 | Aaron Cook | Bronson Arroyo | Aaron Cook | Bronson Arroyo | | 658 | 601 | 57 |
| 2010-09-09 | vs CIN | 140 | W 6-5 | 70-70 | 4 | 25,213 | Jason Hammel | Travis Wood | Matt Belisle | Nick Masset | Huston Street | 664 | 606 | 58 |
| 2010-09-10 | vs ARI | 141 | W 13-4 | 70-71 | 4 | 37,265 | Jorge de la Rosa | Joe Saunders | Jorge de la Rosa | Joe Saunders | | 677 | 610 | 67 |
| 2010-09-11 | vs ARI | 142 | W 2-1 | 71-71 | 4 | 48,023 | Ubaldo Jimenez | Rodrigo Lopez | Matt Reynolds | Rodrigo Lopez | Huston Street | 679 | 611 | 68 |
| 2010-09-12 | vs ARI | 143 | W 4-2 | 72-71 | 4 | 41,504 | Jhoulis Chacin | Ian Kennedy | Huston Street | Sam Demel | | 683 | 613 | 70 |
| 2010-09-13 | vs SDN | 144 | L 4-6 | 72-72 | 4 | 34,089 | Jeff Francis | Cory Luebke | Ernesto Frieri | Jeff Francis | Heath Bell | 687 | 619 | 68 |
| 2010-09-14 | vs SDN | 145 | L 6-7 | 72-73 | 4 | 40,532 | Jason Hammel | Jon Garland | Jon Garland | Jason Hammel | Heath Bell | 693 | 626 | 67 |
| 2010-09-15 | vs SDN | 146 | W 9-6 | 73-73 | 4 | 30,218 | Jorge de la Rosa | Clayton Richard | Jorge de la Rosa | Clayton Richard | Huston Street | 702 | 632 | 70 |
| 2010-09-17 | @ LAN | 147 | W 7-5 | 74-73 | 4 | 38,449 | Ubaldo Jimenez | Hiroki Kuroda | Ubaldo Jimenez | Hiroki Kuroda | Huston Street | 709 | 637 | 72 |
| 2010-09-18 | @ LAN | 148 | W 12-2 | 74-74 | 4 | 40,191 | Jhoulis Chacin | John Ely | Jhoulis Chacin | John Ely | | 721 | 639 | 82 |
| 2010-09-19 | @ LAN | 149 | L 6-7 | 74-75 | 4 | 37,402 | Jason Hammel | Clayton Kershaw | George Sherrill | Manny Delcarmen | | 727 | 646 | 81 |
| 2010-09-21 | @ ARI | 150 | L 1-3 | 74-76 | 4 | 37,460 | Jorge de la Rosa | Joe Saunders | Joe Saunders | Jorge de la Rosa | Juan Gutierrez | 728 | 649 | 79 |
| 2010-09-22 | @ ARI | 151 | L 4-8 | 74-77 | 4 | 29,903 | Ubaldo Jimenez | Rodrigo Lopez | Rodrigo Lopez | Ubaldo Jimenez | Sam Demel | 732 | 657 | 75 |
| 2010-09-23 | @ ARI | 152 | L 9-10 | 75-77 | 4 | 30,093 | Jeff Francis | Ian Kennedy | D.J. Carrasco | Jeff Francis | Juan Gutierrez | 741 | 667 | 74 |
| 2010-09-24 | vs SFN | 153 | L 1-2 | 75-78 | 4 | 49,071 | Jhoulis Chacin | Tim Lincecum | Tim Lincecum | Jhoulis Chacin | Brian Wilson | 742 | 669 | 73 |
| 2010-09-25 | vs SFN | 154 | W 10-9 | 75-79 | 4 | 43,402 | Jason Hammel | Barry Zito | Huston Street | Brian Wilson | | 752 | 678 | 74 |
| 2010-09-26 | vs SFN | 155 | L 2-4 | 75-80 | 4 | 32,594 | Jorge de la Rosa | Matt Cain | Matt Cain | Jorge de la Rosa | | 754 | 682 | 72 |
| 2010-09-27 | vs LAN | 156 | L 1-3 | 75-81 | 4 | 32,085 | Ubaldo Jimenez | Ted Lilly | Ted Lilly | Ubaldo Jimenez | Hong-Chih Kuo | 755 | 685 | 70 |
| 2010-09-28 | vs LAN | 157 | L 7-9 | 75-82 | 4 | 34,430 | Jeff Francis | Hiroki Kuroda | Ronald Belisario | Octavio Dotel | Kenley Jansen | 762 | 694 | 68 |
| 2010-09-29 | vs LAN | 158 | L 6-7 | 75-83 | 4 | 33,296 | Jhoulis Chacin | Carlos Monasterios | Ramon Troncoso | Jhoulis Chacin | Ronald Belisario | 768 | 701 | 67 |
| 2010-09-30 | @ SLN | 159 | L 1-6 | 75-84 | 4 | 36,739 | Jason Hammel | Chris Carpenter | Chris Carpenter | Jason Hammel | | 769 | 707 | 62 |
| 2010-10-01 | @ SLN | 160 | L 0-3 | 75-85 | 4 | 36,293 | Jorge de la Rosa | Jake Westbrook | Jake Westbrook | Jorge de la Rosa | Ryan Franklin | 769 | 710 | 59 |
| 2010-10-02 | @ SLN | 161 | L 0-1 | 75-86 | 4 | 39,633 | Ubaldo Jimenez | Kyle Lohse | Jason Motte | Franklin Morales | | 769 | 711 | 58 |
| 2010-10-03 | @ SLN | 162 | L 1-6 | 75-87 | 4 | 42,409 | Esmil Rogers | Jeff Suppan | Jeff Suppan | Esmil Rogers | | 770 | 717 | 53 |