| 2009-04-06 | @ FLO | 1 | L 6-12 | 1-0 | 2 | 34,323 | John Lannan | Ricky Nolasco | Ricky Nolasco | John Lannan | | 6 | 12 | -6 |
| 2009-04-07 | @ FLO | 2 | L 3-8 | 1-1 | 4 | 11,124 | Scott Olsen | Josh Johnson | Josh Johnson | Scott Olsen | | 9 | 20 | -11 |
| 2009-04-08 | @ FLO | 3 | L 4-6 | 1-2 | 5 | 13,308 | Daniel Cabrera | Chris Volstad | Chris Volstad | Daniel Cabrera | Matt Lindstrom | 13 | 26 | -13 |
| 2009-04-10 | @ ATL | 4 | L 5-6 | 1-3 | 5 | 48,327 | Shairon Martis | Derek Lowe | Jorge Campillo | Joe Beimel | | 18 | 32 | -14 |
| 2009-04-11 | @ ATL | 5 | L 3-5 | 1-4 | 5 | 34,325 | John Lannan | Kenshin Kawakami | Kenshin Kawakami | John Lannan | Mike Gonzalez | 21 | 37 | -16 |
| 2009-04-12 | @ ATL | 6 | L 5-8 | 1-5 | 5 | 19,873 | Scott Olsen | Jair Jurrjens | Jair Jurrjens | Scott Olsen | Rafael Soriano | 26 | 45 | -19 |
| 2009-04-13 | vs PHI | 7 | L 8-9 | 1-6 | 5 | 40,386 | Daniel Cabrera | Jamie Moyer | Jamie Moyer | Saul Rivera | Brad Lidge | 34 | 54 | -20 |
| 2009-04-16 | vs PHI | 8 | W 8-2 | 2-6 | 5 | 20,494 | Shairon Martis | Joe Blanton | Shairon Martis | Joe Blanton | | 42 | 56 | -14 |
| 2009-04-17 | vs FLO | 9 | L 2-3 | 2-7 | 5 | 19,026 | John Lannan | Ricky Nolasco | Leo Nunez | Saul Rivera | Matt Lindstrom | 44 | 59 | -15 |
| 2009-04-18 | vs FLO | 10 | L 6-9 | 2-8 | 5 | 19,864 | Scott Olsen | Josh Johnson | Kiko Calero | Julian Tavarez | | 50 | 68 | -18 |
| 2009-04-19 | vs FLO | 11 | L 4-7 | 2-9 | 5 | 16,974 | Daniel Cabrera | Chris Volstad | Leo Nunez | Saul Rivera | Matt Lindstrom | 54 | 75 | -21 |
| 2009-04-20 | vs ATL | 12 | W 3-2 | 3-9 | 5 | 12,473 | Jordan Zimmermann | Derek Lowe | Jordan Zimmermann | Derek Lowe | Joel Hanrahan | 57 | 77 | -20 |
| 2009-04-21 | vs ATL | 13 | W 4-3 | 4-9 | 5 | 15,439 | Shairon Martis | Kenshin Kawakami | Shairon Martis | Kenshin Kawakami | Joel Hanrahan | 61 | 80 | -19 |
| 2009-04-22 | vs ATL | 14 | L 0-1 | 4-10 | 5 | 15,567 | John Lannan | Jair Jurrjens | Mike Gonzalez | Garrett Mock | Rafael Soriano | 61 | 81 | -20 |
| 2009-04-24 | @ NYN | 15 | L 3-4 | 4-11 | 5 | 40,522 | Scott Olsen | Johan Santana | Johan Santana | Scott Olsen | Francisco Rodriguez | 64 | 85 | -21 |
| 2009-04-25 | @ NYN | 16 | L 2-8 | 4-12 | 5 | 39,960 | Daniel Cabrera | Mike Pelfrey | Mike Pelfrey | Daniel Cabrera | | 66 | 93 | -27 |
| 2009-04-26 | @ NYN | 17 | W 8-1 | 5-12 | 5 | 40,023 | Jordan Zimmermann | Oliver Perez | Jordan Zimmermann | Oliver Perez | | 74 | 94 | -20 |
| 2009-04-27 | @ PHI | 18 | L 11-13 | 5-13 | 5 | 41,620 | Shairon Martis | Joe Blanton | J.A. Happ | Joel Hanrahan | Ryan Madson | 85 | 107 | -22 |
| 2009-04-28 | @ PHI | 19 | L 1-7 | 5-14 | 5 | 43,930 | John Lannan | Cole Hamels | Chad Durbin | John Lannan | | 86 | 114 | -28 |
| 2009-04-29 | @ PHI | 20 | W 4-1 | 6-14 | 5 | 36,351 | Scott Olsen | Brett Myers | Scott Olsen | Brett Myers | Julian Tavarez | 90 | 115 | -25 |
| 2009-04-30 | vs SLN | 21 | L 4-9 | 6-15 | 5 | 18,007 | Daniel Cabrera | Mitchell Boggs | Chris Perez | Julian Tavarez | | 94 | 124 | -30 |
| 2009-05-01 | vs SLN | 22 | L 2-6 | 6-16 | 5 | 20,697 | Jordan Zimmermann | Todd Wellemeyer | Todd Wellemeyer | Jordan Zimmermann | | 96 | 130 | -34 |
| 2009-05-02 | vs SLN | 23 | W 6-1 | 7-16 | 5 | 19,950 | Shairon Martis | Joel Pineiro | Shairon Martis | Joel Pineiro | | 102 | 131 | -29 |
| 2009-05-04 | vs HOU | 24 | W 9-4 | 8-16 | 5 | 14,115 | John Lannan | Brian Moehler | John Lannan | Wesley Wright | | 111 | 135 | -24 |
| 2009-05-05 | vs HOU | 25 | W 11-10 | 9-16 | 5 | 19,328 | Scott Olsen | Roy Oswalt | Joel Hanrahan | LaTroy Hawkins | | 122 | 145 | -23 |
| 2009-05-06 | @ LAN | 26 | L 3-10 | 10-16 | 5 | 31,348 | Daniel Cabrera | Clayton Kershaw | Clayton Kershaw | Daniel Cabrera | | 125 | 155 | -30 |
| 2009-05-07 | @ LAN | 27 | W 11-9 | 10-17 | 5 | 37,074 | Jordan Zimmermann | Randy Wolf | Ron Villone | Cory Wade | | 136 | 164 | -28 |
| 2009-05-08 | @ ARI | 28 | W 5-4 | 11-17 | 5 | 28,640 | Shairon Martis | Yusmeiro Petit | Shairon Martis | Yusmeiro Petit | Kip Wells | 141 | 168 | -27 |
| 2009-05-09 | @ ARI | 29 | W 2-1 | 12-17 | 5 | 27,233 | John Lannan | Doug Davis | John Lannan | Doug Davis | Joel Hanrahan | 143 | 169 | -26 |
| 2009-05-10 | @ ARI | 30 | L 8-10 | 13-17 | 4 | 25,086 | Scott Olsen | Max Scherzer | Esmerling Vasquez | Logan Kensing | Chad Qualls | 151 | 179 | -28 |
| 2009-05-11 | @ SFN | 31 | L 7-11 | 14-17 | 4 | 23,934 | Daniel Cabrera | Randy Johnson | Randy Johnson | Daniel Cabrera | Brian Wilson | 158 | 190 | -32 |
| 2009-05-12 | @ SFN | 32 | L 7-9 | 14-18 | 4 | 25,701 | Jordan Zimmermann | Matt Cain | Brandon Medders | Joe Beimel | | 165 | 199 | -34 |
| 2009-05-13 | @ SFN | 33 | W 6-3 | 15-18 | 4 | 30,120 | Shairon Martis | Barry Zito | Shairon Martis | Barry Zito | Kip Wells | 171 | 202 | -31 |
| 2009-05-15 | vs PHI | 34 | L 6-10 | 16-18 | 3 | 23,430 | John Lannan | Joe Blanton | J.A. Happ | Kip Wells | | 177 | 212 | -35 |
| 2009-05-16 | vs PHI | 35 | L 5-8 | 16-20 | 5 | 19,910 | Scott Olsen | Brett Myers | Brett Myers | Scott Olsen | Brad Lidge | 182 | 220 | -38 |
| 2009-05-16 | vs PHI | 36 | L 5-7 | 16-20 | 5 | 23,896 | Daniel Cabrera | Andrew Carpenter | Andrew Carpenter | Daniel Cabrera | Clay Condrey | 187 | 227 | -40 |
| 2009-05-17 | vs PHI | 37 | L 6-8 | 16-21 | 5 | 29,577 | Jordan Zimmermann | Chan Ho Park | Sergio Escalona | Julian Tavarez | Brad Lidge | 193 | 235 | -42 |
| 2009-05-18 | vs PIT | 38 | L 7-12 | 17-21 | 4 | 14,549 | Ross Detwiler | Ross Ohlendorf | Ross Ohlendorf | Garrett Mock | | 200 | 247 | -47 |
| 2009-05-19 | vs PIT | 39 | L 5-8 | 17-22 | 5 | 18,579 | Shairon Martis | Jeff Karstens | Tom Gorzelanny | Joe Beimel | | 205 | 255 | -50 |
| 2009-05-20 | vs PIT | 40 | L 1-2 | 17-23 | 6 | 17,854 | John Lannan | Paul Maholm | John Grabow | Joel Hanrahan | Matt Capps | 206 | 257 | -51 |
| 2009-05-21 | vs PIT | 41 | W 5-4 | 18-23 | 4 | 17,816 | Craig Stammen | Ian Snell | Julian Tavarez | Tom Gorzelanny | Joel Hanrahan | 211 | 261 | -50 |
| 2009-05-22 | vs BAL | 42 | L 2-4 | 18-24 | 5 | 22,556 | Jordan Zimmermann | Rich Hill | Danys Baez | Kip Wells | George Sherrill | 213 | 265 | -52 |
| 2009-05-23 | vs BAL | 43 | L 1-2 | 18-25 | 5 | 31,833 | Ross Detwiler | Koji Uehara | Brian Bass | Julian Tavarez | George Sherrill | 214 | 267 | -53 |
| 2009-05-24 | vs BAL | 44 | W 8-5 | 19-25 | 5 | 30,880 | Shairon Martis | Brad Bergesen | Ron Villone | Chris Ray | Joel Hanrahan | 222 | 272 | -50 |
| 2009-05-25 | @ NYN | 45 | L 2-5 | 19-26 | 5 | 41,103 | John Lannan | John Maine | John Maine | John Lannan | Francisco Rodriguez | 224 | 277 | -53 |
| 2009-05-26 | @ NYN | 46 | L 1-6 | 19-27 | 5 | 39,376 | Craig Stammen | Livan Hernandez | Livan Hernandez | Craig Stammen | | 225 | 283 | -58 |
| 2009-05-27 | @ NYN | 47 | L 4-7 | 19-28 | 5 | 40,171 | Jordan Zimmermann | Johan Santana | Johan Santana | Jordan Zimmermann | | 229 | 290 | -61 |
| 2009-05-29 | @ PHI | 48 | L 4-5 | 19-29 | 5 | 45,202 | Ross Detwiler | J.A. Happ | J.A. Happ | Ross Detwiler | Brad Lidge | 233 | 295 | -62 |
| 2009-05-30 | @ PHI | 49 | L 6-9 | 19-30 | 5 | 45,121 | Shairon Martis | Cole Hamels | Cole Hamels | Shairon Martis | Brad Lidge | 239 | 304 | -65 |
| 2009-05-31 | @ PHI | 50 | L 2-4 | 19-31 | 5 | 45,239 | John Lannan | Jamie Moyer | Jamie Moyer | John Lannan | Brad Lidge | 241 | 308 | -67 |
| 2009-06-02 | vs SFN | 51 | W 10-6 | 19-32 | 5 | 17,331 | Craig Stammen | Tim Lincecum | Ron Villone | Bob Howry | | 251 | 314 | -63 |
| 2009-06-04 | vs SFN | 52 | L 1-5 | 19-34 | 6 | 0 | Jordan Zimmermann | Randy Johnson | Randy Johnson | Jordan Zimmermann | Brian Wilson | 252 | 319 | -67 |
| 2009-06-04 | vs SFN | 53 | L 1-4 | 19-34 | 6 | 16,787 | Ross Detwiler | Matt Cain | Matt Cain | Ross Detwiler | | 253 | 323 | -70 |
| 2009-06-05 | vs NYN | 54 | L 1-3 | 19-35 | 5 | 20,353 | Shairon Martis | Tim Redding | Sean Green | Joel Hanrahan | Francisco Rodriguez | 254 | 326 | -72 |
| 2009-06-06 | vs NYN | 55 | W 7-1 | 20-35 | 5 | 31,456 | John Lannan | John Maine | John Lannan | John Maine | | 261 | 327 | -66 |
| 2009-06-07 | vs NYN | 56 | L 0-7 | 20-36 | 5 | 31,841 | Craig Stammen | Livan Hernandez | Livan Hernandez | Craig Stammen | | 261 | 334 | -73 |
| 2009-06-09 | vs CIN | 57 | L 2-3 | 20-37 | 5 | 16,274 | Ross Detwiler | Johnny Cueto | Johnny Cueto | Ross Detwiler | Francisco Cordero | 263 | 337 | -74 |
| 2009-06-10 | vs CIN | 58 | L 2-4 | 20-38 | 5 | 19,790 | Shairon Martis | Aaron Harang | Nick Masset | Ron Villone | David Weathers | 265 | 341 | -76 |
| 2009-06-11 | vs CIN | 59 | W 3-2 | 21-38 | 5 | 19,703 | John Lannan | Micah Owings | Julian Tavarez | Danny Herrera | Joe Beimel | 268 | 343 | -75 |
| 2009-06-12 | @ TBA | 60 | L 3-4 | 21-39 | 5 | 18,273 | Craig Stammen | Matt Garza | J.P. Howell | Ron Villone | | 271 | 347 | -76 |
| 2009-06-13 | @ TBA | 61 | L 3-8 | 21-40 | 5 | 30,586 | Jordan Zimmermann | Andy Sonnanstine | Andy Sonnanstine | Jason Bergmann | | 274 | 355 | -81 |
| 2009-06-14 | @ TBA | 62 | L 4-5 | 21-41 | 5 | 25,841 | Ross Detwiler | James Shields | Dan Wheeler | Ron Villone | J.P. Howell | 278 | 360 | -82 |
| 2009-06-16 | @ NYA | 63 | L 3-5 | 21-42 | 5 | 44,873 | Shairon Martis | CC Sabathia | CC Sabathia | Ron Villone | Mariano Rivera | 281 | 365 | -84 |
| 2009-06-17 | @ NYA | 64 | W 3-2 | 22-42 | 5 | 46,052 | John Lannan | Chien-Ming Wang | John Lannan | Chien-Ming Wang | Mike MacDougal | 284 | 367 | -83 |
| 2009-06-18 | @ NYA | 65 | W 3-0 | 23-42 | 5 | 45,143 | Craig Stammen | Joba Chamberlain | Craig Stammen | Joba Chamberlain | Mike MacDougal | 287 | 367 | -80 |
| 2009-06-19 | vs TOR | 66 | W 2-1 | 24-42 | 5 | 20,860 | Jordan Zimmermann | Brian Tallet | Jesus Colome | Jason Frasor | | 289 | 368 | -79 |
| 2009-06-20 | vs TOR | 67 | W 5-3 | 25-42 | 5 | 22,142 | Ross Detwiler | Brett Cecil | Julian Tavarez | Scott Richmond | | 294 | 371 | -77 |
| 2009-06-21 | vs TOR | 68 | L 4-9 | 25-43 | 5 | 26,610 | Shairon Martis | Ricky Romero | Ricky Romero | Shairon Martis | | 298 | 380 | -82 |
| 2009-06-23 | vs BOS | 69 | L 3-11 | 26-43 | 5 | 41,517 | John Lannan | Brad Penny | Manny Delcarmen | Julian Tavarez | | 301 | 391 | -90 |
| 2009-06-24 | vs BOS | 70 | L 4-6 | 26-44 | 5 | 41,530 | Craig Stammen | Jon Lester | Jon Lester | Craig Stammen | Jonathan Papelbon | 305 | 397 | -92 |
| 2009-06-25 | vs BOS | 71 | W 9-3 | 27-44 | 5 | 41,985 | Jordan Zimmermann | John Smoltz | Jordan Zimmermann | John Smoltz | | 314 | 400 | -86 |
| 2009-06-26 | @ BAL | 72 | L 1-11 | 27-45 | 5 | 45,024 | Ross Detwiler | Brad Bergesen | Brad Bergesen | Ross Detwiler | | 315 | 411 | -96 |
| 2009-06-27 | @ BAL | 73 | L 3-6 | 27-46 | 5 | 39,633 | Shairon Martis | Jeremy Guthrie | Jeremy Guthrie | Shairon Martis | George Sherrill | 318 | 417 | -99 |
| 2009-06-28 | @ BAL | 74 | W 5-3 | 28-46 | 5 | 25,068 | John Lannan | David Hernandez | John Lannan | David Hernandez | Mike MacDougal | 323 | 420 | -97 |
| 2009-06-29 | @ FLO | 75 | L 2-4 | 28-47 | 5 | 10,623 | Scott Olsen | Ricky Nolasco | Ricky Nolasco | Ron Villone | Leo Nunez | 325 | 424 | -99 |
| 2009-06-30 | @ FLO | 76 | L 5-7 | 28-48 | 5 | 11,821 | Craig Stammen | Sean West | Renyel Pinto | Joe Beimel | | 330 | 431 | -101 |
| 2009-07-01 | @ FLO | 77 | L 3-5 | 28-49 | 5 | 27,032 | Jordan Zimmermann | Josh Johnson | Dan Meyer | Julian Tavarez | Leo Nunez | 333 | 436 | -103 |
| 2009-07-03 | vs ATL | 78 | L 8-9 | 28-50 | 5 | 33,982 | Ross Detwiler | Kenshin Kawakami | Boone Logan | Jesus Colome | Rafael Soriano | 341 | 445 | -104 |
| 2009-07-04 | vs ATL | 79 | W 5-3 | 29-50 | 5 | 23,708 | John Lannan | Tommy Hanson | John Lannan | Mike Gonzalez | Mike MacDougal | 346 | 448 | -102 |
| 2009-07-05 | vs ATL | 80 | W 5-3 | 30-50 | 5 | 22,677 | Scott Olsen | Derek Lowe | Scott Olsen | Derek Lowe | Mike MacDougal | 351 | 451 | -100 |
| 2009-07-06 | @ COL | 81 | L 0-1 | 30-51 | 5 | 25,205 | Craig Stammen | Jason Marquis | Jason Marquis | Craig Stammen | Huston Street | 351 | 452 | -101 |
| 2009-07-07 | @ COL | 82 | L 4-5 | 30-52 | 5 | 25,314 | Jordan Zimmermann | Jason Hammel | Alan Embree | Julian Tavarez | Huston Street | 355 | 457 | -102 |
| 2009-07-08 | @ COL | 83 | L 4-10 | 31-52 | 5 | 23,098 | Ross Detwiler | Jorge de la Rosa | Jorge de la Rosa | Ross Detwiler | | 359 | 467 | -108 |
| 2009-07-09 | @ HOU | 84 | L 4-9 | 31-53 | 5 | 25,490 | John Lannan | Russ Ortiz | Alberto Arias | John Lannan | | 363 | 476 | -113 |
| 2009-07-10 | @ HOU | 85 | L 5-6 | 31-54 | 5 | 33,085 | Scott Olsen | Roy Oswalt | Jeff Fulchino | Joe Beimel | | 368 | 482 | -114 |
| 2009-07-11 | @ HOU | 86 | W 13-2 | 31-55 | 5 | 30,052 | Craig Stammen | Mike Hampton | Craig Stammen | Mike Hampton | | 381 | 484 | -103 |
| 2009-07-12 | @ HOU | 87 | L 0-5 | 31-56 | 5 | 28,680 | Jordan Zimmermann | Brian Moehler | Brian Moehler | Jordan Zimmermann | Jose Valverde | 381 | 489 | -108 |
| 2009-07-16 | vs CHN | 88 | L 2-6 | 31-57 | 5 | 26,980 | John Lannan | Rich Harden | Rich Harden | John Lannan | | 383 | 495 | -112 |
| 2009-07-17 | vs CHN | 89 | L 1-3 | 31-58 | 5 | 27,581 | Craig Stammen | Carlos Zambrano | Carlos Zambrano | Craig Stammen | Kevin Gregg | 384 | 498 | -114 |
| 2009-07-18 | vs CHN | 90 | L 5-6 | 31-59 | 5 | 36,014 | Jordan Zimmermann | Randy Wells | Randy Wells | Jordan Zimmermann | Kevin Gregg | 389 | 504 | -115 |
| 2009-07-19 | vs CHN | 91 | L 3-11 | 32-59 | 5 | 34,574 | Garrett Mock | Kevin Hart | Kevin Hart | Garrett Mock | | 392 | 515 | -123 |
| 2009-07-20 | vs NYN | 92 | L 2-6 | 32-60 | 5 | 19,169 | J.D. Martin | Livan Hernandez | Livan Hernandez | J.D. Martin | | 394 | 521 | -127 |
| 2009-07-21 | vs NYN | 93 | W 4-0 | 33-60 | 5 | 23,414 | John Lannan | Oliver Perez | John Lannan | Oliver Perez | | 398 | 521 | -123 |
| 2009-07-22 | vs NYN | 94 | W 3-1 | 34-60 | 5 | 23,583 | Craig Stammen | Mike Pelfrey | Craig Stammen | Mike Pelfrey | Mike MacDougal | 401 | 522 | -121 |
| 2009-07-23 | vs SLN | 95 | L 1-4 | 34-61 | 5 | 25,359 | Collin Balester | Adam Wainwright | Adam Wainwright | Collin Balester | | 402 | 526 | -124 |
| 2009-07-24 | vs SDN | 96 | L 2-6 | 34-62 | 5 | 23,506 | Garrett Mock | Mat Latos | Mat Latos | Garrett Mock | | 404 | 532 | -128 |
| 2009-07-25 | vs SDN | 97 | W 13-1 | 35-62 | 5 | 21,834 | J.D. Martin | Tim Stauffer | Tyler Clippard | Tim Stauffer | | 417 | 533 | -116 |
| 2009-07-26 | vs SDN | 98 | W 3-2 | 36-62 | 5 | 20,747 | John Lannan | Chad Gaudin | Joe Beimel | Greg Burke | | 420 | 535 | -115 |
| 2009-07-27 | @ MIL | 99 | W 14-6 | 36-63 | 5 | 37,311 | Craig Stammen | Jeff Suppan | Jason Bergmann | Jeff Suppan | | 434 | 541 | -107 |
| 2009-07-28 | @ MIL | 100 | W 8-3 | 37-63 | 5 | 36,502 | Collin Balester | Carlos Villanueva | Collin Balester | Carlos Villanueva | | 442 | 544 | -102 |
| 2009-07-29 | @ MIL | 101 | L 5-7 | 37-64 | 5 | 32,992 | Garrett Mock | Manny Parra | Manny Parra | Tyler Clippard | Trevor Hoffman | 447 | 551 | -104 |
| 2009-07-30 | @ MIL | 102 | L 3-7 | 37-65 | 6 | 39,890 | J.D. Martin | Yovani Gallardo | Yovani Gallardo | J.D. Martin | | 450 | 558 | -108 |
| 2009-07-31 | @ PIT | 103 | L 4-5 | 37-66 | 5 | 23,363 | John Lannan | Ross Ohlendorf | Ross Ohlendorf | John Lannan | Matt Capps | 454 | 563 | -109 |
| 2009-08-01 | @ PIT | 104 | L 6-11 | 38-66 | 5 | 26,855 | Craig Stammen | Virgil Vasquez | Virgil Vasquez | Craig Stammen | | 460 | 574 | -114 |
| 2009-08-02 | @ PIT | 105 | W 5-3 | 39-66 | 5 | 21,894 | Collin Balester | Paul Maholm | Sean Burnett | Paul Maholm | Mike MacDougal | 465 | 577 | -112 |
| 2009-08-03 | @ PIT | 106 | W 8-4 | 40-66 | 5 | 11,630 | Garrett Mock | Charlie Morton | Tyler Clippard | Charlie Morton | Mike MacDougal | 473 | 581 | -108 |
| 2009-08-04 | vs FLO | 107 | W 6-4 | 41-66 | 5 | 19,828 | J.D. Martin | Josh Johnson | Ron Villone | Kiko Calero | Mike MacDougal | 479 | 585 | -106 |
| 2009-08-05 | vs FLO | 108 | W 5-4 | 42-66 | 5 | 18,312 | John Lannan | Rick Vanden Hurk | John Lannan | Rick Vanden Hurk | Mike MacDougal | 484 | 589 | -105 |
| 2009-08-06 | vs FLO | 109 | W 12-8 | 42-67 | 5 | 23,691 | Craig Stammen | Chris Volstad | Jorge Sosa | Luis Ayala | | 496 | 597 | -101 |
| 2009-08-07 | vs ARI | 110 | W 7-6 | 43-67 | 5 | 22,674 | Collin Balester | Jon Garland | Jason Bergmann | Juan Gutierrez | Mike MacDougal | 503 | 603 | -100 |
| 2009-08-08 | vs ARI | 111 | W 5-2 | 44-67 | 5 | 24,551 | Garrett Mock | Dan Haren | Garrett Mock | Dan Haren | Jorge Sosa | 508 | 605 | -97 |
| 2009-08-09 | vs ARI | 112 | W 9-2 | 45-67 | 5 | 19,938 | J.D. Martin | Yusmeiro Petit | J.D. Martin | Yusmeiro Petit | Jorge Sosa | 517 | 607 | -90 |
| 2009-08-11 | @ ATL | 113 | L 1-8 | 45-68 | 5 | 19,273 | John Lannan | Tommy Hanson | Tommy Hanson | John Lannan | | 518 | 615 | -97 |
| 2009-08-12 | @ ATL | 114 | L 2-6 | 45-69 | 5 | 17,886 | Craig Stammen | Derek Lowe | Derek Lowe | Jorge Sosa | | 520 | 621 | -101 |
| 2009-08-13 | @ CIN | 115 | L 0-7 | 45-70 | 5 | 16,889 | Collin Balester | Bronson Arroyo | Bronson Arroyo | Collin Balester | | 520 | 628 | -108 |
| 2009-08-14 | @ CIN | 116 | W 2-0 | 46-70 | 5 | 19,606 | Garrett Mock | Aaron Harang | Garrett Mock | Aaron Harang | Mike MacDougal | 522 | 628 | -106 |
| 2009-08-15 | @ CIN | 117 | W 10-6 | 46-71 | 5 | 30,494 | J.D. Martin | Johnny Cueto | J.D. Martin | Johnny Cueto | | 532 | 634 | -102 |
| 2009-08-16 | @ CIN | 118 | W 5-4 | 47-71 | 6 | 18,030 | John Lannan | Justin Lehr | Jorge Sosa | Arthur Rhodes | Mike MacDougal | 537 | 638 | -101 |
| 2009-08-18 | vs COL | 119 | L 3-4 | 47-72 | 5 | 18,192 | Craig Stammen | Ubaldo Jimenez | Ubaldo Jimenez | Sean Burnett | Huston Street | 540 | 642 | -102 |
| 2009-08-19 | vs COL | 120 | L 4-5 | 47-73 | 5 | 16,187 | Collin Balester | Jason Marquis | Jason Marquis | Collin Balester | Huston Street | 544 | 647 | -103 |
| 2009-08-20 | vs COL | 121 | L 1-4 | 47-74 | 5 | 18,036 | Garrett Mock | Jason Hammel | Jason Hammel | Garrett Mock | Huston Street | 545 | 651 | -106 |
| 2009-08-21 | vs MIL | 122 | L 3-7 | 47-75 | 5 | 26,307 | J.D. Martin | Braden Looper | Braden Looper | J.D. Martin | | 548 | 658 | -110 |
| 2009-08-22 | vs MIL | 123 | L 9-11 | 48-75 | 5 | 19,374 | John Lannan | Mike Burns | Chris Narveson | Jason Bergmann | Trevor Hoffman | 557 | 669 | -112 |
| 2009-08-23 | vs MIL | 124 | W 8-3 | 49-75 | 5 | 21,484 | Craig Stammen | Manny Parra | Craig Stammen | Manny Parra | | 565 | 672 | -107 |
| 2009-08-24 | vs MIL | 125 | L 1-7 | 49-76 | 5 | 17,805 | Collin Balester | Yovani Gallardo | Yovani Gallardo | Collin Balester | | 566 | 679 | -113 |
| 2009-08-25 | @ CHN | 126 | W 15-6 | 49-77 | 5 | 37,297 | Garrett Mock | Carlos Zambrano | Garrett Mock | Carlos Zambrano | | 581 | 685 | -104 |
| 2009-08-26 | @ CHN | 127 | L 4-9 | 49-78 | 5 | 36,562 | Livan Hernandez | Rich Harden | Angel Guzman | Jason Bergmann | | 585 | 694 | -109 |
| 2009-08-27 | @ CHN | 128 | W 5-4 | 50-78 | 5 | 35,174 | J.D. Martin | Randy Wells | J.D. Martin | Randy Wells | Mike MacDougal | 590 | 698 | -108 |
| 2009-08-28 | @ SLN | 129 | L 2-3 | 50-79 | 5 | 40,033 | John Lannan | John Smoltz | Jason Motte | Jason Bergmann | | 592 | 701 | -109 |
| 2009-08-29 | @ SLN | 130 | L 4-9 | 50-80 | 5 | 44,028 | Craig Stammen | Mitchell Boggs | Mitchell Boggs | Craig Stammen | | 596 | 710 | -114 |
| 2009-08-30 | @ SLN | 131 | L 1-2 | 50-81 | 5 | 41,083 | Garrett Mock | Adam Wainwright | Adam Wainwright | Garrett Mock | Ryan Franklin | 597 | 712 | -115 |
| 2009-08-31 | @ SDN | 132 | L 1-3 | 50-82 | 5 | 19,867 | Livan Hernandez | Tim Stauffer | Tim Stauffer | Livan Hernandez | Heath Bell | 598 | 715 | -117 |
| 2009-09-01 | @ SDN | 133 | L 1-4 | 50-83 | 5 | 15,131 | J.D. Martin | Clayton Richard | Clayton Richard | J.D. Martin | Heath Bell | 599 | 719 | -120 |
| 2009-09-02 | @ SDN | 134 | L 0-7 | 50-84 | 5 | 14,468 | John Lannan | Kevin Correia | Kevin Correia | John Lannan | | 599 | 726 | -127 |
| 2009-09-04 | vs FLO | 135 | L 6-9 | 50-85 | 5 | 16,364 | Garrett Mock | Sean West | Burke Badenhop | Garrett Mock | Leo Nunez | 605 | 735 | -130 |
| 2009-09-05 | vs FLO | 136 | L 5-9 | 50-86 | 5 | 18,111 | Livan Hernandez | Josh Johnson | Josh Johnson | Livan Hernandez | | 610 | 744 | -134 |
| 2009-09-06 | vs FLO | 137 | W 5-4 | 51-86 | 5 | 22,325 | J.D. Martin | Anibal Sanchez | Mike MacDougal | Leo Nunez | | 615 | 748 | -133 |
| 2009-09-08 | vs PHI | 138 | L 3-5 | 51-87 | 5 | 17,153 | John Lannan | Pedro Martinez | Pedro Martinez | John Lannan | Ryan Madson | 618 | 753 | -135 |
| 2009-09-09 | vs PHI | 139 | L 5-6 | 51-88 | 5 | 16,818 | Garrett Mock | Cliff Lee | Cliff Lee | Tyler Clippard | Ryan Madson | 623 | 759 | -136 |
| 2009-09-10 | vs PHI | 140 | W 8-7 | 52-88 | 5 | 18,706 | Livan Hernandez | Joe Blanton | Livan Hernandez | Joe Blanton | Ron Villone | 631 | 766 | -135 |
| 2009-09-11 | @ FLO | 141 | W 5-3 | 53-88 | 5 | 15,247 | J.D. Martin | Josh Johnson | J.D. Martin | Brian Sanches | Mike MacDougal | 636 | 769 | -133 |
| 2009-09-12 | @ FLO | 142 | L 3-11 | 54-88 | 5 | 38,214 | Marco Estrada | Anibal Sanchez | Tim Wood | Marco Estrada | | 639 | 780 | -141 |
| 2009-09-13 | @ FLO | 143 | W 7-2 | 55-88 | 7 | 15,065 | John Lannan | Chris Volstad | John Lannan | Chris Volstad | | 646 | 782 | -136 |
| 2009-09-15 | @ PHI | 144 | L 0-5 | 55-89 | 5 | 44,521 | Garrett Mock | Cliff Lee | Cliff Lee | Garrett Mock | | 646 | 787 | -141 |
| 2009-09-16 | @ PHI | 145 | L 1-6 | 55-90 | 5 | 44,223 | Livan Hernandez | Joe Blanton | Joe Blanton | Livan Hernandez | | 647 | 793 | -146 |
| 2009-09-17 | @ PHI | 146 | L 2-4 | 55-91 | 5 | 45,210 | Ross Detwiler | Cole Hamels | Cole Hamels | Ross Detwiler | Brad Lidge | 649 | 797 | -148 |
| 2009-09-18 | @ NYN | 147 | W 6-5 | 56-91 | 5 | 38,063 | J.D. Martin | Mike Pelfrey | J.D. Martin | Mike Pelfrey | Mike MacDougal | 655 | 802 | -147 |
| 2009-09-19 | @ NYN | 148 | L 2-3 | 56-92 | 5 | 37,906 | John Lannan | Tim Redding | Tim Redding | John Lannan | Francisco Rodriguez | 657 | 805 | -148 |
| 2009-09-20 | @ NYN | 149 | L 2-6 | 56-93 | 5 | 38,347 | Garrett Mock | John Maine | John Maine | Garrett Mock | Francisco Rodriguez | 659 | 811 | -152 |
| 2009-09-22 | vs LAN | 150 | L 2-14 | 57-93 | 7 | 18,518 | Livan Hernandez | Hiroki Kuroda | Hiroki Kuroda | Livan Hernandez | | 661 | 825 | -164 |
| 2009-09-23 | vs LAN | 151 | W 5-4 | 58-93 | 5 | 18,635 | Ross Detwiler | Chad Billingsley | Saul Rivera | James McDonald | | 666 | 829 | -163 |
| 2009-09-24 | vs LAN | 152 | L 6-7 | 58-94 | 5 | 22,432 | J.D. Martin | Vicente Padilla | Ramon Troncoso | Ron Villone | Jonathan Broxton | 672 | 836 | -164 |
| 2009-09-25 | vs ATL | 153 | L 1-4 | 58-95 | 5 | 28,276 | John Lannan | Javier Vazquez | Javier Vazquez | John Lannan | | 673 | 840 | -167 |
| 2009-09-26 | vs ATL | 154 | L 5-11 | 59-95 | 5 | 29,058 | Garrett Mock | Tommy Hanson | Tommy Hanson | Garrett Mock | | 678 | 851 | -173 |
| 2009-09-27 | vs ATL | 155 | L 3-6 | 59-96 | 5 | 27,840 | Livan Hernandez | Derek Lowe | Mike Gonzalez | Mike MacDougal | Rafael Soriano | 681 | 857 | -176 |
| 2009-09-28 | vs NYN | 156 | W 2-1 | 60-96 | 5 | 18,600 | Ross Detwiler | Nelson Figueroa | Ross Detwiler | Nelson Figueroa | Mike MacDougal | 683 | 858 | -175 |
| 2009-09-29 | vs NYN | 157 | W 4-3 | 61-96 | 5 | 19,614 | J.D. Martin | Mike Pelfrey | Tyler Clippard | Sean Green | Mike MacDougal | 687 | 861 | -174 |
| 2009-09-30 | vs NYN | 158 | W 7-4 | 62-96 | 5 | 23,944 | John Lannan | Tim Redding | Ron Villone | Francisco Rodriguez | | 694 | 865 | -171 |
| 2009-10-01 | @ ATL | 159 | W 2-1 | 63-96 | 5 | 38,237 | Garrett Mock | Tommy Hanson | Tyler Clippard | Rafael Soriano | Mike MacDougal | 696 | 866 | -170 |
| 2009-10-02 | @ ATL | 160 | W 6-3 | 64-96 | 5 | 33,124 | Livan Hernandez | Derek Lowe | Livan Hernandez | Derek Lowe | Mike MacDougal | 702 | 869 | -167 |
| 2009-10-03 | @ ATL | 161 | W 6-4 | 65-96 | 5 | 28,278 | Ross Detwiler | Jair Jurrjens | Zack Segovia | Manny Acosta | Logan Kensing | 708 | 873 | -165 |
| 2009-10-04 | @ ATL | 162 | W 2-1 | 66-96 | 5 | 36,307 | J.D. Martin | Tim Hudson | Logan Kensing | Boone Logan | | 710 | 874 | -164 |