| 2009-04-06 | vs SEA | 1 | L 1-6 | 0-1 | 3 | 48,514 | Francisco Liriano | Felix Hernandez | Felix Hernandez | Francisco Liriano | | 1 | 6 | -5 |
| 2009-04-07 | vs SEA | 2 | W 6-5 | 1-1 | 3 | 23,755 | Nick Blackburn | Erik Bedard | Luis Ayala | Brandon Morrow | | 7 | 11 | -4 |
| 2009-04-08 | vs SEA | 3 | W 6-5 | 2-1 | 2 | 22,270 | Kevin Slowey | Carlos Silva | Kevin Slowey | Carlos Silva | Joe Nathan | 13 | 16 | -3 |
| 2009-04-09 | vs SEA | 4 | L 0-2 | 2-2 | 3 | 20,105 | Glen Perkins | Jarrod Washburn | Jarrod Washburn | Glen Perkins | Brandon Morrow | 13 | 18 | -5 |
| 2009-04-10 | @ CHA | 5 | W 12-5 | 2-3 | 5 | 25,422 | R.A. Dickey | Jose Contreras | R.A. Dickey | Jose Contreras | | 25 | 23 | 2 |
| 2009-04-11 | @ CHA | 6 | L 0-8 | 2-4 | 5 | 33,935 | Francisco Liriano | Bartolo Colon | Bartolo Colon | Francisco Liriano | | 25 | 31 | -6 |
| 2009-04-12 | @ CHA | 7 | L 1-6 | 2-5 | 5 | 25,571 | Nick Blackburn | Mark Buehrle | Mark Buehrle | Nick Blackburn | Bobby Jenks | 26 | 37 | -11 |
| 2009-04-13 | vs TOR | 8 | L 6-8 | 2-6 | 5 | 16,410 | Kevin Slowey | Jesse Litsch | Jason Frasor | Luis Ayala | B.J. Ryan | 32 | 45 | -13 |
| 2009-04-14 | vs TOR | 9 | W 3-2 | 3-6 | 5 | 15,375 | Glen Perkins | Ricky Romero | Jesse Crain | Jesse Carlson | | 35 | 47 | -12 |
| 2009-04-15 | vs TOR | 10 | L 2-12 | 4-6 | 5 | 19,471 | Scott Baker | Scott Richmond | Scott Richmond | Scott Baker | | 37 | 59 | -22 |
| 2009-04-16 | vs TOR | 11 | L 2-9 | 4-7 | 5 | 15,169 | Francisco Liriano | Roy Halladay | Roy Halladay | Francisco Liriano | | 39 | 68 | -29 |
| 2009-04-17 | vs ANA | 12 | W 11-9 | 4-8 | 5 | 24,168 | Nick Blackburn | Dustin Moseley | Matt Guerrier | Jason Bulger | Joe Nathan | 50 | 77 | -27 |
| 2009-04-18 | vs ANA | 13 | W 9-2 | 5-8 | 4 | 34,286 | Kevin Slowey | Darren Oliver | Kevin Slowey | Kevin Jepsen | | 59 | 79 | -20 |
| 2009-04-19 | vs ANA | 14 | W 3-1 | 6-8 | 4 | 28,302 | Glen Perkins | Shane Loux | Glen Perkins | Shane Loux | Joe Nathan | 62 | 80 | -18 |
| 2009-04-22 | @ BOS | 15 | L 1-10 | 6-10 | 5 | 37,608 | Scott Baker | Tim Wakefield | Tim Wakefield | Scott Baker | | 63 | 90 | -27 |
| 2009-04-22 | @ BOS | 16 | L 3-7 | 6-10 | 5 | 37,494 | Francisco Liriano | Brad Penny | Brad Penny | Francisco Liriano | | 66 | 97 | -31 |
| 2009-04-24 | @ CLE | 17 | W 5-1 | 7-10 | 4 | 20,219 | Nick Blackburn | Fausto Carmona | Nick Blackburn | Fausto Carmona | | 71 | 98 | -27 |
| 2009-04-25 | @ CLE | 18 | W 7-1 | 8-10 | 4 | 23,186 | Kevin Slowey | Carl Pavano | Kevin Slowey | Carl Pavano | | 78 | 99 | -21 |
| 2009-04-26 | @ CLE | 19 | L 2-4 | 8-11 | 4 | 20,153 | Glen Perkins | Aaron Laffey | Aaron Laffey | Glen Perkins | Kerry Wood | 80 | 103 | -23 |
| 2009-04-27 | vs TBA | 20 | L 1-7 | 8-12 | 4 | 17,988 | Scott Baker | Jeff Niemann | Jeff Niemann | Scott Baker | | 81 | 110 | -29 |
| 2009-04-28 | vs TBA | 21 | W 4-3 | 9-12 | 5 | 18,974 | Francisco Liriano | James Shields | Joe Nathan | J.P. Howell | | 85 | 113 | -28 |
| 2009-04-29 | vs TBA | 22 | W 8-3 | 10-12 | 3 | 21,715 | Nick Blackburn | Scott Kazmir | Nick Blackburn | Scott Kazmir | | 93 | 116 | -23 |
| 2009-05-01 | vs KCA | 23 | W 7-5 | 11-12 | 3 | 24,727 | Kevin Slowey | Sidney Ponson | Kevin Slowey | Sidney Ponson | Joe Nathan | 100 | 121 | -21 |
| 2009-05-02 | vs KCA | 24 | L 7-10 | 12-12 | 2 | 29,061 | Glen Perkins | Brian Bannister | Joakim Soria | Craig Breslow | | 107 | 131 | -24 |
| 2009-05-03 | vs KCA | 25 | L 5-7 | 12-13 | 2 | 31,845 | Scott Baker | Gil Meche | Gil Meche | Scott Baker | Joakim Soria | 112 | 138 | -26 |
| 2009-05-04 | @ DET | 26 | W 7-2 | 13-13 | 2 | 21,298 | Francisco Liriano | Edwin Jackson | Francisco Liriano | Edwin Jackson | | 119 | 140 | -21 |
| 2009-05-05 | @ DET | 27 | L 0-9 | 13-14 | 3 | 23,754 | Nick Blackburn | Rick Porcello | Rick Porcello | Nick Blackburn | | 119 | 149 | -30 |
| 2009-05-06 | @ BAL | 28 | L 1-4 | 13-15 | 3 | 10,566 | Kevin Slowey | Mark Hendrickson | Brian Bass | Kevin Slowey | | 120 | 153 | -33 |
| 2009-05-07 | @ BAL | 29 | L 4-5 | 13-16 | 4 | 11,399 | Glen Perkins | Brad Bergesen | Jim Johnson | Jose Mijares | George Sherrill | 124 | 158 | -34 |
| 2009-05-08 | vs SEA | 30 | W 11-0 | 14-16 | 3 | 29,714 | Scott Baker | Chris Jakubauskas | Scott Baker | Chris Jakubauskas | | 135 | 158 | -23 |
| 2009-05-09 | vs SEA | 31 | W 9-6 | 15-16 | 3 | 29,552 | Francisco Liriano | Felix Hernandez | Francisco Liriano | Felix Hernandez | Joe Nathan | 144 | 164 | -20 |
| 2009-05-10 | vs SEA | 32 | L 3-5 | 15-17 | 3 | 25,555 | Nick Blackburn | Erik Bedard | Miguel Batista | Jesse Crain | Brandon Morrow | 147 | 169 | -22 |
| 2009-05-12 | vs DET | 33 | W 6-2 | 16-17 | 3 | 24,807 | Kevin Slowey | Armando Galarraga | Kevin Slowey | Armando Galarraga | | 153 | 171 | -18 |
| 2009-05-13 | vs DET | 34 | W 14-10 | 17-17 | 2 | 22,178 | Glen Perkins | Dontrelle Willis | Jesse Crain | Brandon Lyon | | 167 | 181 | -14 |
| 2009-05-14 | vs DET | 35 | W 6-5 | 18-17 | 2 | 26,046 | Scott Baker | Justin Verlander | Craig Breslow | Bobby Seay | Joe Nathan | 173 | 186 | -13 |
| 2009-05-15 | @ NYA | 36 | L 4-5 | 18-18 | 2 | 43,856 | Francisco Liriano | Phil Hughes | Jose Veras | Joe Nathan | | 177 | 191 | -14 |
| 2009-05-16 | @ NYA | 37 | L 4-6 | 18-19 | 2 | 45,455 | Nick Blackburn | Joba Chamberlain | Alfredo Aceves | Craig Breslow | | 181 | 197 | -16 |
| 2009-05-17 | @ NYA | 38 | L 2-3 | 18-20 | 3 | 44,804 | Kevin Slowey | A.J. Burnett | Alfredo Aceves | Jesse Crain | | 183 | 200 | -17 |
| 2009-05-18 | @ NYA | 39 | L 6-7 | 18-21 | 3 | 43,244 | Glen Perkins | Andy Pettitte | Andy Pettitte | Glen Perkins | Phil Coke | 189 | 207 | -18 |
| 2009-05-19 | @ CHA | 40 | L 2-6 | 18-22 | 3 | 26,696 | Scott Baker | Mark Buehrle | Mark Buehrle | Scott Baker | | 191 | 213 | -22 |
| 2009-05-20 | @ CHA | 41 | L 4-7 | 18-23 | 3 | 29,044 | Francisco Liriano | John Danks | John Danks | Francisco Liriano | Bobby Jenks | 195 | 220 | -25 |
| 2009-05-21 | @ CHA | 42 | W 20-1 | 19-23 | 3 | 23,048 | Nick Blackburn | Bartolo Colon | Nick Blackburn | Bartolo Colon | | 215 | 221 | -6 |
| 2009-05-22 | vs MIL | 43 | W 11-3 | 19-24 | 3 | 30,297 | Kevin Slowey | Manny Parra | Kevin Slowey | Manny Parra | | 226 | 224 | 2 |
| 2009-05-23 | vs MIL | 44 | W 6-2 | 20-24 | 2 | 40,547 | Anthony Swarzak | Braden Looper | Anthony Swarzak | Braden Looper | | 232 | 226 | 6 |
| 2009-05-24 | vs MIL | 45 | W 6-3 | 21-24 | 2 | 38,959 | Scott Baker | David Bush | Scott Baker | David Bush | | 238 | 229 | 9 |
| 2009-05-25 | vs BOS | 46 | L 5-6 | 21-25 | 2 | 27,636 | Francisco Liriano | Brad Penny | Brad Penny | Francisco Liriano | Jonathan Papelbon | 243 | 235 | 8 |
| 2009-05-26 | vs BOS | 47 | W 5-2 | 22-25 | 2 | 20,019 | Nick Blackburn | Jon Lester | Nick Blackburn | Jon Lester | Joe Nathan | 248 | 237 | 11 |
| 2009-05-27 | vs BOS | 48 | W 4-2 | 23-25 | 2 | 28,221 | Kevin Slowey | Daisuke Matsuzaka | Kevin Slowey | Daisuke Matsuzaka | Joe Nathan | 252 | 239 | 13 |
| 2009-05-28 | vs BOS | 49 | L 1-3 | 23-26 | 2 | 23,958 | Anthony Swarzak | Josh Beckett | Josh Beckett | Anthony Swarzak | Jonathan Papelbon | 253 | 242 | 11 |
| 2009-05-29 | @ TBA | 50 | L 3-5 | 23-27 | 2 | 19,358 | Scott Baker | James Shields | James Shields | Scott Baker | Randy Choate | 256 | 247 | 9 |
| 2009-05-30 | @ TBA | 51 | L 2-5 | 23-28 | 2 | 36,052 | Francisco Liriano | David Price | David Price | Francisco Liriano | Randy Choate | 258 | 252 | 6 |
| 2009-05-31 | @ TBA | 52 | W 3-2 | 24-28 | 2 | 26,579 | Nick Blackburn | Matt Garza | Nick Blackburn | Matt Garza | Joe Nathan | 261 | 254 | 7 |
| 2009-06-02 | vs CLE | 53 | W 4-3 | 25-28 | 2 | 26,530 | Kevin Slowey | David Huff | Kevin Slowey | David Huff | Joe Nathan | 265 | 257 | 8 |
| 2009-06-03 | vs CLE | 54 | L 1-10 | 25-29 | 2 | 29,336 | Anthony Swarzak | Cliff Lee | Cliff Lee | Anthony Swarzak | | 266 | 267 | -1 |
| 2009-06-04 | vs CLE | 55 | W 11-3 | 25-30 | 2 | 20,897 | Scott Baker | Fausto Carmona | Scott Baker | Fausto Carmona | | 277 | 270 | 7 |
| 2009-06-05 | @ SEA | 56 | W 2-1 | 26-30 | 2 | 35,808 | Francisco Liriano | Felix Hernandez | Matt Guerrier | Mark Lowe | Joe Nathan | 279 | 271 | 8 |
| 2009-06-06 | @ SEA | 57 | L 1-2 | 26-31 | 2 | 30,600 | Nick Blackburn | Jarrod Washburn | Chris Jakubauskas | Sean Henn | David Aardsma | 280 | 273 | 7 |
| 2009-06-07 | @ SEA | 58 | L 2-4 | 26-32 | 3 | 37,714 | Kevin Slowey | Erik Bedard | Erik Bedard | Kevin Slowey | Sean White | 282 | 277 | 5 |
| 2009-06-08 | @ OAK | 59 | L 3-4 | 26-33 | 4 | 10,181 | Anthony Swarzak | Josh Outman | Josh Outman | Luis Ayala | Andrew Bailey | 285 | 281 | 4 |
| 2009-06-09 | @ OAK | 60 | W 10-5 | 26-34 | 3 | 10,127 | Scott Baker | Brett Anderson | Scott Baker | Brett Anderson | Joe Nathan | 295 | 286 | 9 |
| 2009-06-10 | @ OAK | 61 | W 6-3 | 27-34 | 3 | 18,074 | Francisco Liriano | Dallas Braden | Matt Guerrier | Andrew Bailey | Joe Nathan | 301 | 289 | 12 |
| 2009-06-11 | @ OAK | 62 | L 3-4 | 27-35 | 3 | 13,383 | Nick Blackburn | Trevor Cahill | Brad Ziegler | Sean Henn | | 304 | 293 | 11 |
| 2009-06-12 | @ CHN | 63 | W 7-4 | 28-35 | 3 | 41,509 | Kevin Slowey | Randy Wells | Kevin Slowey | Randy Wells | Joe Nathan | 311 | 297 | 14 |
| 2009-06-13 | @ CHN | 64 | W 2-0 | 29-35 | 3 | 40,899 | Anthony Swarzak | Rich Harden | Anthony Swarzak | Rich Harden | Joe Nathan | 313 | 297 | 16 |
| 2009-06-14 | @ CHN | 65 | L 2-3 | 29-36 | 3 | 40,814 | Scott Baker | Ted Lilly | Carlos Marmol | Jesse Crain | | 315 | 300 | 15 |
| 2009-06-16 | vs PIT | 66 | W 8-2 | 30-36 | 3 | 25,351 | Glen Perkins | Paul Maholm | Glen Perkins | Paul Maholm | | 323 | 302 | 21 |
| 2009-06-17 | vs PIT | 67 | L 2-8 | 30-37 | 4 | 30,057 | Francisco Liriano | Ian Snell | Ian Snell | Francisco Liriano | | 325 | 310 | 15 |
| 2009-06-18 | vs PIT | 68 | W 5-1 | 31-37 | 3 | 30,670 | Nick Blackburn | Zach Duke | Nick Blackburn | Zach Duke | | 330 | 311 | 19 |
| 2009-06-19 | vs HOU | 69 | W 5-2 | 32-37 | 3 | 32,218 | Kevin Slowey | Roy Oswalt | Kevin Slowey | Roy Oswalt | Joe Nathan | 335 | 313 | 22 |
| 2009-06-20 | vs HOU | 70 | L 5-6 | 32-38 | 3 | 34,710 | Scott Baker | Brian Moehler | Brian Moehler | Sean Henn | Jose Valverde | 340 | 319 | 21 |
| 2009-06-21 | vs HOU | 71 | L 1-4 | 32-39 | 3 | 39,659 | Glen Perkins | Wandy Rodriguez | Wandy Rodriguez | Glen Perkins | Jose Valverde | 341 | 323 | 18 |
| 2009-06-23 | @ MIL | 72 | W 7-3 | 33-39 | 3 | 42,008 | Francisco Liriano | Jeff Suppan | Francisco Liriano | Jeff Suppan | | 348 | 326 | 22 |
| 2009-06-24 | @ MIL | 73 | L 3-4 | 33-40 | 4 | 34,480 | Nick Blackburn | Braden Looper | Todd Coffey | Nick Blackburn | Trevor Hoffman | 351 | 330 | 21 |
| 2009-06-25 | @ MIL | 74 | W 6-4 | 34-40 | 3 | 40,524 | Scott Baker | Mike Burns | Scott Baker | Mike Burns | Joe Nathan | 357 | 334 | 23 |
| 2009-06-26 | @ SLN | 75 | W 3-1 | 35-40 | 3 | 44,159 | Glen Perkins | Adam Wainwright | Glen Perkins | Adam Wainwright | Joe Nathan | 360 | 335 | 25 |
| 2009-06-27 | @ SLN | 76 | L 3-5 | 35-41 | 3 | 42,986 | Kevin Slowey | Todd Wellemeyer | Josh Kinney | Kevin Slowey | Ryan Franklin | 363 | 340 | 23 |
| 2009-06-28 | @ SLN | 77 | W 6-2 | 36-41 | 3 | 42,705 | Francisco Liriano | Joel Pineiro | Francisco Liriano | Joel Pineiro | Joe Nathan | 369 | 342 | 27 |
| 2009-06-29 | @ KCA | 78 | L 2-4 | 36-42 | 3 | 22,066 | Nick Blackburn | Luke Hochevar | Luke Hochevar | Nick Blackburn | Joakim Soria | 371 | 346 | 25 |
| 2009-06-30 | @ KCA | 79 | W 2-1 | 37-42 | 3 | 19,310 | Scott Baker | Brian Bannister | Scott Baker | Brian Bannister | Joe Nathan | 373 | 347 | 26 |
| 2009-07-01 | @ KCA | 80 | W 5-1 | 38-42 | 2 | 18,906 | Glen Perkins | Gil Meche | Glen Perkins | Gil Meche | Joe Nathan | 378 | 348 | 30 |
| 2009-07-03 | vs DET | 81 | L 9-11 | 39-42 | 2 | 33,368 | Kevin Slowey | Lucas French | Freddy Dolsi | R.A. Dickey | | 387 | 359 | 28 |
| 2009-07-04 | vs DET | 82 | W 4-3 | 40-42 | 2 | 27,238 | Francisco Liriano | Edwin Jackson | Matt Guerrier | Brandon Lyon | Joe Nathan | 391 | 362 | 29 |
| 2009-07-05 | vs DET | 83 | W 6-2 | 41-42 | 2 | 33,274 | Nick Blackburn | Rick Porcello | Nick Blackburn | Rick Porcello | | 397 | 364 | 33 |
| 2009-07-07 | vs NYA | 84 | L 2-10 | 42-42 | 2 | 29,540 | Scott Baker | CC Sabathia | CC Sabathia | Scott Baker | | 399 | 374 | 25 |
| 2009-07-08 | vs NYA | 85 | L 3-4 | 42-43 | 2 | 38,115 | Anthony Swarzak | A.J. Burnett | A.J. Burnett | Anthony Swarzak | Mariano Rivera | 402 | 378 | 24 |
| 2009-07-09 | vs NYA | 86 | L 4-6 | 42-44 | 2 | 40,142 | Francisco Liriano | Alfredo Aceves | Jonathan Albaladejo | Francisco Liriano | Mariano Rivera | 406 | 384 | 22 |
| 2009-07-10 | vs CHA | 87 | W 6-4 | 43-44 | 2 | 29,628 | Nick Blackburn | John Danks | Nick Blackburn | Octavio Dotel | Joe Nathan | 412 | 388 | 24 |
| 2009-07-11 | vs CHA | 88 | L 7-8 | 43-45 | 2 | 41,146 | Glen Perkins | Gavin Floyd | Gavin Floyd | Glen Perkins | Bobby Jenks | 419 | 396 | 23 |
| 2009-07-12 | vs CHA | 89 | W 13-7 | 43-46 | 2 | 36,254 | Scott Baker | Mark Buehrle | Scott Baker | Mark Buehrle | | 432 | 403 | 29 |
| 2009-07-17 | @ TEX | 90 | W 5-3 | 44-46 | 2 | 34,662 | Glen Perkins | Vicente Padilla | Glen Perkins | Vicente Padilla | Joe Nathan | 437 | 406 | 31 |
| 2009-07-18 | @ TEX | 91 | W 4-1 | 45-46 | 2 | 31,041 | Scott Baker | Scott Feldman | Scott Baker | Scott Feldman | Joe Nathan | 441 | 407 | 34 |
| 2009-07-19 | @ TEX | 92 | L 3-5 | 45-47 | 2 | 27,204 | Francisco Liriano | Derek Holland | Dustin Nippert | Brian Duensing | | 444 | 412 | 32 |
| 2009-07-20 | @ OAK | 93 | L 13-14 | 45-48 | 2 | 10,283 | Nick Blackburn | Gio Gonzalez | Craig Breslow | Jose Mijares | Michael Wuertz | 457 | 426 | 31 |
| 2009-07-21 | @ OAK | 94 | W 3-2 | 46-48 | 2 | 12,027 | Anthony Swarzak | Dallas Braden | Matt Guerrier | Andrew Bailey | Joe Nathan | 460 | 428 | 32 |
| 2009-07-22 | @ OAK | 95 | L 1-16 | 46-49 | 2 | 22,031 | Glen Perkins | Trevor Cahill | Trevor Cahill | Glen Perkins | | 461 | 444 | 17 |
| 2009-07-23 | @ ANA | 96 | L 5-6 | 46-50 | 2 | 38,145 | Scott Baker | Jered Weaver | Brian Fuentes | Jesse Crain | | 466 | 450 | 16 |
| 2009-07-24 | @ ANA | 97 | L 3-6 | 46-51 | 3 | 39,272 | Francisco Liriano | John Lackey | John Lackey | Francisco Liriano | | 469 | 456 | 13 |
| 2009-07-25 | @ ANA | 98 | L 5-11 | 47-51 | 2 | 35,922 | Nick Blackburn | Matt Palmer | Matt Palmer | Nick Blackburn | | 474 | 467 | 7 |
| 2009-07-26 | @ ANA | 99 | W 10-1 | 48-51 | 2 | 36,386 | Anthony Swarzak | Ervin Santana | Anthony Swarzak | Ervin Santana | | 484 | 468 | 16 |
| 2009-07-27 | vs CHA | 100 | W 4-3 | 49-51 | 2 | 32,354 | Glen Perkins | John Danks | Glen Perkins | John Danks | Joe Nathan | 488 | 471 | 17 |
| 2009-07-28 | vs CHA | 101 | W 5-3 | 50-51 | 2 | 34,642 | Scott Baker | Mark Buehrle | Jose Mijares | Mark Buehrle | Joe Nathan | 493 | 474 | 19 |
| 2009-07-29 | vs CHA | 102 | W 3-2 | 51-51 | 2 | 39,002 | Brian Duensing | Jose Contreras | Jesse Crain | Jose Contreras | Joe Nathan | 496 | 476 | 20 |
| 2009-07-31 | vs ANA | 103 | L 5-11 | 52-51 | 2 | 31,767 | Nick Blackburn | Ervin Santana | Kevin Jepsen | Bobby Keppel | | 501 | 487 | 14 |
| 2009-08-01 | vs ANA | 104 | L 6-11 | 53-51 | 2 | 40,828 | Anthony Swarzak | Joe Saunders | Joe Saunders | Anthony Swarzak | | 507 | 498 | 9 |
| 2009-08-02 | vs ANA | 105 | L 4-13 | 54-51 | 2 | 41,079 | Glen Perkins | Jered Weaver | Jered Weaver | Glen Perkins | | 511 | 511 | 0 |
| 2009-08-04 | @ CLE | 106 | W 10-1 | 55-51 | 2 | 17,518 | Scott Baker | David Huff | Scott Baker | David Huff | | 521 | 512 | 9 |
| 2009-08-05 | @ CLE | 107 | L 1-8 | 55-52 | 2 | 17,683 | Francisco Liriano | Aaron Laffey | Aaron Laffey | Francisco Liriano | | 522 | 520 | 2 |
| 2009-08-06 | @ CLE | 108 | L 1-2 | 55-53 | 2 | 21,657 | Nick Blackburn | Fausto Carmona | Tony Sipp | Nick Blackburn | Kerry Wood | 523 | 522 | 1 |
| 2009-08-07 | @ DET | 109 | L 8-10 | 56-53 | 2 | 36,444 | Anthony Swarzak | Armando Galarraga | Armando Galarraga | Anthony Swarzak | | 531 | 532 | -1 |
| 2009-08-08 | @ DET | 110 | W 11-0 | 57-53 | 2 | 39,685 | Carl Pavano | Justin Verlander | Carl Pavano | Justin Verlander | | 542 | 532 | 10 |
| 2009-08-09 | @ DET | 111 | L 7-8 | 57-54 | 2 | 35,423 | Scott Baker | Jarrod Washburn | Brandon Lyon | Matt Guerrier | Fernando Rodney | 549 | 540 | 9 |
| 2009-08-11 | vs KCA | 112 | L 6-14 | 58-54 | 2 | 32,121 | Nick Blackburn | Kyle Davies | Kyle Davies | Nick Blackburn | | 555 | 554 | 1 |
| 2009-08-12 | vs KCA | 113 | W 7-1 | 59-54 | 1 | 30,105 | Francisco Liriano | Brian Bannister | Francisco Liriano | Brian Bannister | | 562 | 555 | 7 |
| 2009-08-13 | vs KCA | 114 | L 4-5 | 59-55 | 2 | 32,373 | Carl Pavano | Gil Meche | Gil Meche | Carl Pavano | Joakim Soria | 566 | 560 | 6 |
| 2009-08-14 | vs CLE | 115 | W 11-0 | 60-55 | 2 | 34,845 | Scott Baker | Justin Masterson | Scott Baker | Justin Masterson | | 577 | 560 | 17 |
| 2009-08-15 | vs CLE | 116 | L 3-7 | 60-56 | 2 | 33,931 | Anthony Swarzak | David Huff | David Huff | Anthony Swarzak | | 580 | 567 | 13 |
| 2009-08-16 | vs CLE | 117 | L 4-7 | 60-57 | 2 | 30,260 | Nick Blackburn | Aaron Laffey | Aaron Laffey | Nick Blackburn | | 584 | 574 | 10 |
| 2009-08-17 | @ TEX | 118 | L 5-8 | 60-58 | 2 | 17,940 | Francisco Liriano | Tommy Hunter | Tommy Hunter | Francisco Liriano | Frank Francisco | 589 | 582 | 7 |
| 2009-08-18 | @ TEX | 119 | W 9-6 | 61-58 | 2 | 20,931 | Carl Pavano | Scott Feldman | Jesse Crain | Jason Jennings | Joe Nathan | 598 | 588 | 10 |
| 2009-08-19 | @ TEX | 120 | W 5-4 | 62-58 | 1 | 33,479 | Scott Baker | Kevin Millwood | Scott Baker | Kevin Millwood | Joe Nathan | 603 | 592 | 11 |
| 2009-08-20 | @ TEX | 121 | L 1-11 | 62-59 | 2 | 21,870 | Anthony Swarzak | Derek Holland | Derek Holland | Anthony Swarzak | | 604 | 603 | 1 |
| 2009-08-21 | @ KCA | 122 | W 5-4 | 63-59 | 2 | 22,283 | Nick Blackburn | Luke Hochevar | Joe Nathan | Joakim Soria | | 609 | 607 | 2 |
| 2009-08-22 | @ KCA | 123 | W 8-7 | 64-59 | 1 | 33,811 | Brian Duensing | Kyle Davies | Brian Duensing | Kyle Davies | Matt Guerrier | 617 | 614 | 3 |
| 2009-08-23 | @ KCA | 124 | W 10-3 | 64-60 | 1 | 18,680 | Carl Pavano | Brian Bannister | Carl Pavano | Brian Bannister | | 627 | 617 | 10 |
| 2009-08-24 | vs BAL | 125 | W 2-1 | 65-60 | 1 | 20,271 | Scott Baker | Chris Tillman | Scott Baker | Chris Tillman | Joe Nathan | 629 | 618 | 11 |
| 2009-08-25 | vs BAL | 126 | W 7-6 | 66-60 | 1 | 23,696 | Armando Gabino | Brian Matusz | Jose Mijares | Kameron Mickolio | | 636 | 624 | 12 |
| 2009-08-26 | vs BAL | 127 | L 1-5 | 66-61 | 1 | 28,446 | Nick Blackburn | Jeremy Guthrie | Jeremy Guthrie | Nick Blackburn | | 637 | 629 | 8 |
| 2009-08-28 | vs TEX | 128 | W 3-2 | 67-61 | 1 | 21,641 | Brian Duensing | Tommy Hunter | Brian Duensing | Tommy Hunter | Joe Nathan | 640 | 631 | 9 |
| 2009-08-29 | vs TEX | 129 | L 0-3 | 67-62 | 1 | 28,516 | Carl Pavano | Scott Feldman | Scott Feldman | Carl Pavano | Frank Francisco | 640 | 634 | 6 |
| 2009-08-30 | vs TEX | 130 | W 5-3 | 68-62 | 1 | 29,282 | Scott Baker | Kevin Millwood | Jon Rauch | C.J. Wilson | Joe Nathan | 645 | 637 | 8 |
| 2009-08-31 | vs CHA | 131 | W 4-1 | 69-62 | 1 | 19,426 | Nick Blackburn | Gavin Floyd | Nick Blackburn | Gavin Floyd | Joe Nathan | 649 | 638 | 11 |
| 2009-09-01 | vs CHA | 132 | W 4-3 | 70-62 | 1 | 22,599 | Jeff Manship | John Danks | Jon Rauch | Matt Thornton | | 653 | 641 | 12 |
| 2009-09-02 | vs CHA | 133 | L 2-4 | 70-63 | 1 | 21,007 | Brian Duensing | Mark Buehrle | D.J. Carrasco | Joe Nathan | Bobby Jenks | 655 | 645 | 10 |
| 2009-09-04 | @ CLE | 134 | L 2-5 | 70-64 | 2 | 24,402 | Carl Pavano | Jeremy Sowers | Jeremy Sowers | Carl Pavano | Kerry Wood | 657 | 650 | 7 |
| 2009-09-05 | @ CLE | 135 | W 4-1 | 71-64 | 2 | 19,455 | Scott Baker | Justin Masterson | Scott Baker | Justin Masterson | Joe Nathan | 661 | 651 | 10 |
| 2009-09-06 | @ CLE | 136 | L 1-3 | 71-65 | 2 | 17,911 | Nick Blackburn | David Huff | David Huff | Nick Blackburn | Kerry Wood | 662 | 654 | 8 |
| 2009-09-07 | @ TOR | 137 | W 6-3 | 72-65 | 2 | 13,153 | Jeff Manship | Scott Richmond | Jesse Crain | Scott Richmond | Joe Nathan | 668 | 657 | 11 |
| 2009-09-08 | @ TOR | 138 | L 3-6 | 72-66 | 2 | 13,488 | Brian Duensing | Ricky Romero | Ricky Romero | Jon Rauch | Jason Frasor | 671 | 663 | 8 |
| 2009-09-09 | @ TOR | 139 | W 4-1 | 73-66 | 2 | 11,159 | Carl Pavano | Roy Halladay | Carl Pavano | Roy Halladay | Joe Nathan | 675 | 664 | 11 |
| 2009-09-10 | @ TOR | 140 | L 2-3 | 73-67 | 2 | 11,461 | Scott Baker | Brett Cecil | Brett Cecil | Scott Baker | Jason Frasor | 677 | 667 | 10 |
| 2009-09-11 | vs OAK | 141 | L 5-12 | 74-67 | 1 | 21,084 | Nick Blackburn | Clayton Mortenson | Clayton Mortenson | Nick Blackburn | | 682 | 679 | 3 |
| 2009-09-12 | vs OAK | 142 | L 2-4 | 74-68 | 1 | 24,283 | Jeff Manship | Brett Anderson | Brett Anderson | Jeff Manship | Andrew Bailey | 684 | 683 | 1 |
| 2009-09-13 | vs OAK | 143 | W 8-0 | 75-68 | 1 | 21,850 | Brian Duensing | Gio Gonzalez | Brian Duensing | Gio Gonzalez | | 692 | 683 | 9 |
| 2009-09-14 | vs CLE | 144 | W 6-3 | 76-68 | 1 | 20,640 | Carl Pavano | Jeremy Sowers | Ron Mahay | Chris Perez | Joe Nathan | 698 | 686 | 12 |
| 2009-09-15 | vs CLE | 145 | W 5-4 | 77-68 | 1 | 19,035 | Scott Baker | Fausto Carmona | Jon Rauch | Fausto Carmona | Joe Nathan | 703 | 690 | 13 |
| 2009-09-16 | vs CLE | 146 | W 7-3 | 78-68 | 1 | 16,921 | Nick Blackburn | Aaron Laffey | Nick Blackburn | Aaron Laffey | Joe Nathan | 710 | 693 | 17 |
| 2009-09-18 | vs DET | 147 | W 3-0 | 79-68 | 1 | 32,693 | Brian Duensing | Rick Porcello | Brian Duensing | Rick Porcello | Joe Nathan | 713 | 693 | 20 |
| 2009-09-19 | vs DET | 148 | W 6-2 | 80-68 | 1 | 43,338 | Carl Pavano | Justin Verlander | Jesse Crain | Justin Verlander | | 719 | 695 | 24 |
| 2009-09-20 | vs DET | 149 | L 2-6 | 80-69 | 1 | 36,335 | Scott Baker | Nate Robertson | Nate Robertson | Scott Baker | | 721 | 701 | 20 |
| 2009-09-21 | @ CHA | 150 | W 7-0 | 81-69 | 1 | 26,541 | Nick Blackburn | Daniel Hudson | Nick Blackburn | Daniel Hudson | | 728 | 701 | 27 |
| 2009-09-22 | @ CHA | 151 | W 8-6 | 82-69 | 1 | 25,290 | Jeff Manship | John Danks | Jesse Crain | John Danks | Joe Nathan | 736 | 707 | 29 |
| 2009-09-23 | @ CHA | 152 | W 8-6 | 83-69 | 1 | 26,097 | Brian Duensing | Mark Buehrle | Brian Duensing | Mark Buehrle | Joe Nathan | 744 | 713 | 31 |
| 2009-09-25 | @ KCA | 153 | W 9-4 | 84-69 | 1 | 23,307 | Carl Pavano | Rob Tejeda | Carl Pavano | Rob Tejeda | | 753 | 717 | 36 |
| 2009-09-26 | @ KCA | 154 | W 11-6 | 84-70 | 1 | 30,690 | Scott Baker | Lenny DiNardo | Scott Baker | Lenny DiNardo | | 764 | 723 | 41 |
| 2009-09-27 | @ KCA | 155 | L 1-4 | 84-71 | 1 | 28,721 | Francisco Liriano | Zack Greinke | Zack Greinke | Francisco Liriano | Joakim Soria | 765 | 727 | 38 |
| 2009-09-29 | @ DET | 156 | W 3-2 | 85-72 | 2 | 35,243 | Nick Blackburn | Rick Porcello | Jon Rauch | Brandon Lyon | Joe Nathan | 768 | 729 | 39 |
| 2009-09-29 | @ DET | 157 | L 5-6 | 85-72 | 2 | 30,240 | Brian Duensing | Justin Verlander | Justin Verlander | Brian Duensing | Fernando Rodney | 773 | 735 | 38 |
| 2009-09-30 | @ DET | 158 | L 2-7 | 85-73 | 1 | 34,775 | Carl Pavano | Eddie Bonine | Eddie Bonine | Carl Pavano | | 775 | 742 | 33 |
| 2009-10-01 | @ DET | 159 | W 8-3 | 86-73 | 1 | 40,533 | Scott Baker | Nate Robertson | Scott Baker | Nate Robertson | | 783 | 745 | 38 |
| 2009-10-02 | vs KCA | 160 | W 10-7 | 86-74 | 1 | 40,223 | Jeff Manship | Lenny DiNardo | Jeff Manship | Lenny DiNardo | Joe Nathan | 793 | 752 | 41 |
| 2009-10-03 | vs KCA | 161 | W 5-4 | 87-74 | 1 | 48,644 | Nick Blackburn | Zack Greinke | Jon Rauch | Dusty Hughes | Joe Nathan | 798 | 756 | 42 |
| 2009-10-04 | vs KCA | 162 | W 13-4 | 87-75 | 1 | 51,155 | Carl Pavano | Luke Hochevar | Carl Pavano | Luke Hochevar | | 811 | 760 | 51 |
| 2009-10-06 | vs DET | 163 | W 6-5 | 88-75 | 1 | 54,088 | Scott Baker | Rick Porcello | Bobby Keppel | Fernando Rodney | | 817 | 765 | 52 |