| 2009-04-07 | @ CHA | 1 | L 2-4 | 0-1 | 4 | 37,449 | Gil Meche | Mark Buehrle | Octavio Dotel | Kyle Farnsworth | Bobby Jenks | 2 | 4 | -2 |
| 2009-04-08 | @ CHA | 2 | W 2-0 | 1-1 | 4 | 22,817 | Zack Greinke | Gavin Floyd | Zack Greinke | Gavin Floyd | Joakim Soria | 4 | 4 | 0 |
| 2009-04-09 | @ CHA | 3 | W 2-1 | 2-1 | 1 | 18,091 | Kyle Davies | John Danks | Ron Mahay | Bobby Jenks | Joakim Soria | 6 | 5 | 1 |
| 2009-04-10 | vs NYA | 4 | L 1-4 | 2-2 | 3 | 38,098 | Sidney Ponson | Andy Pettitte | Andy Pettitte | Sidney Ponson | Mariano Rivera | 7 | 9 | -2 |
| 2009-04-11 | vs NYA | 5 | L 1-6 | 2-3 | 4 | 31,271 | Horacio Ramirez | CC Sabathia | CC Sabathia | Horacio Ramirez | | 8 | 15 | -7 |
| 2009-04-12 | vs NYA | 6 | W 6-4 | 3-3 | 4 | 17,629 | Gil Meche | Joba Chamberlain | Juan Cruz | Phil Coke | Joakim Soria | 14 | 19 | -5 |
| 2009-04-13 | vs CLE | 7 | W 4-2 | 4-3 | 3 | 10,061 | Zack Greinke | Fausto Carmona | Zack Greinke | Fausto Carmona | Joakim Soria | 18 | 21 | -3 |
| 2009-04-14 | vs CLE | 8 | W 9-3 | 5-3 | 1 | 11,756 | Kyle Davies | Carl Pavano | Kyle Davies | Carl Pavano | | 27 | 24 | 3 |
| 2009-04-15 | vs CLE | 9 | L 4-5 | 5-4 | 2 | 13,589 | Sidney Ponson | Aaron Laffey | Jensen Lewis | Kyle Farnsworth | Kerry Wood | 31 | 29 | 2 |
| 2009-04-17 | @ TEX | 10 | W 12-3 | 5-5 | 3 | 24,062 | Gil Meche | Matt Harrison | Gil Meche | Matt Harrison | | 43 | 32 | 11 |
| 2009-04-18 | @ TEX | 11 | W 2-0 | 6-5 | 3 | 37,635 | Zack Greinke | Kevin Millwood | Zack Greinke | Kevin Millwood | | 45 | 32 | 13 |
| 2009-04-19 | @ TEX | 12 | L 5-6 | 6-6 | 3 | 27,635 | Kyle Davies | Vicente Padilla | Frank Francisco | Kyle Farnsworth | | 50 | 38 | 12 |
| 2009-04-21 | @ CLE | 13 | L 7-8 | 6-7 | 3 | 11,408 | Sidney Ponson | Aaron Laffey | Aaron Laffey | Sidney Ponson | Kerry Wood | 57 | 46 | 11 |
| 2009-04-22 | @ CLE | 14 | W 2-0 | 7-7 | 3 | 13,509 | Brian Bannister | Cliff Lee | Brian Bannister | Cliff Lee | Joakim Soria | 59 | 46 | 13 |
| 2009-04-23 | @ CLE | 15 | L 2-5 | 7-8 | 3 | 12,852 | Gil Meche | Anthony Reyes | Jensen Lewis | Gil Meche | Kerry Wood | 61 | 51 | 10 |
| 2009-04-24 | vs DET | 16 | W 6-1 | 8-8 | 3 | 36,363 | Zack Greinke | Rick Porcello | Zack Greinke | Rick Porcello | | 67 | 52 | 15 |
| 2009-04-25 | vs DET | 17 | L 1-9 | 8-9 | 3 | 37,647 | Kyle Davies | Zach Miner | Zach Miner | Kyle Davies | | 68 | 61 | 7 |
| 2009-04-26 | vs DET | 18 | L 2-3 | 8-10 | 3 | 13,520 | Sidney Ponson | Armando Galarraga | Armando Galarraga | Sidney Ponson | Fernando Rodney | 70 | 64 | 6 |
| 2009-04-27 | vs TOR | 19 | W 7-1 | 9-10 | 2 | 9,685 | Brian Bannister | David Purcey | Brian Bannister | David Purcey | | 77 | 65 | 12 |
| 2009-04-28 | vs TOR | 20 | L 1-8 | 9-11 | 4 | 15,191 | Gil Meche | Scott Richmond | Scott Richmond | Gil Meche | | 78 | 73 | 5 |
| 2009-04-29 | vs TOR | 21 | W 11-3 | 9-12 | 4 | 10,619 | Zack Greinke | Brian Tallet | Zack Greinke | Brian Tallet | | 89 | 76 | 13 |
| 2009-04-30 | vs TOR | 22 | W 8-6 | 10-12 | 3 | 11,896 | Kyle Davies | Brian Burres | Kyle Davies | Brian Burres | Juan Cruz | 97 | 82 | 15 |
| 2009-05-01 | @ MIN | 23 | L 5-7 | 10-13 | 4 | 24,727 | Sidney Ponson | Kevin Slowey | Kevin Slowey | Sidney Ponson | Joe Nathan | 102 | 89 | 13 |
| 2009-05-02 | @ MIN | 24 | W 10-7 | 10-14 | 4 | 29,061 | Brian Bannister | Glen Perkins | Joakim Soria | Craig Breslow | | 112 | 96 | 16 |
| 2009-05-03 | @ MIN | 25 | W 7-5 | 11-14 | 4 | 31,845 | Gil Meche | Scott Baker | Gil Meche | Scott Baker | Joakim Soria | 119 | 101 | 18 |
| 2009-05-04 | vs CHA | 26 | W 3-0 | 12-14 | 3 | 21,843 | Zack Greinke | Bartolo Colon | Zack Greinke | Bartolo Colon | | 122 | 101 | 21 |
| 2009-05-05 | vs CHA | 27 | W 8-7 | 13-14 | 2 | 13,419 | Kyle Davies | Gavin Floyd | Juan Cruz | Lance Broadway | | 130 | 108 | 22 |
| 2009-05-06 | vs SEA | 28 | W 9-1 | 14-14 | 2 | 15,324 | Sidney Ponson | Carlos Silva | Sidney Ponson | Carlos Silva | | 139 | 109 | 30 |
| 2009-05-07 | vs SEA | 29 | W 3-1 | 15-14 | 2 | 32,714 | Brian Bannister | Jarrod Washburn | Brian Bannister | Jarrod Washburn | Joakim Soria | 142 | 110 | 32 |
| 2009-05-08 | @ ANA | 30 | L 1-4 | 15-15 | 2 | 41,019 | Gil Meche | Matt Palmer | Matt Palmer | Gil Meche | Brian Fuentes | 143 | 114 | 29 |
| 2009-05-09 | @ ANA | 31 | L 0-1 | 15-16 | 2 | 39,776 | Zack Greinke | Joe Saunders | Joe Saunders | Zack Greinke | | 143 | 115 | 28 |
| 2009-05-10 | @ ANA | 32 | L 3-4 | 15-17 | 2 | 43,646 | Kyle Davies | Shane Loux | Scot Shields | Jamey Wright | Brian Fuentes | 146 | 119 | 27 |
| 2009-05-12 | @ OAK | 33 | L 3-12 | 16-17 | 2 | 10,156 | Luke Hochevar | Trevor Cahill | Trevor Cahill | Luke Hochevar | | 149 | 131 | 18 |
| 2009-05-13 | @ OAK | 34 | L 2-7 | 16-18 | 3 | 16,057 | Brian Bannister | Josh Outman | Josh Outman | Brian Bannister | | 151 | 138 | 13 |
| 2009-05-14 | vs BAL | 35 | L 5-9 | 16-19 | 3 | 24,431 | Gil Meche | Jeremy Guthrie | Jeremy Guthrie | Gil Meche | | 156 | 147 | 9 |
| 2009-05-15 | vs BAL | 36 | W 8-1 | 17-19 | 3 | 38,353 | Zack Greinke | Adam Eaton | Zack Greinke | Adam Eaton | | 164 | 148 | 16 |
| 2009-05-16 | vs BAL | 37 | L 2-3 | 17-20 | 3 | 26,720 | Kyle Davies | Rich Hill | Rich Hill | Kyle Davies | George Sherrill | 166 | 151 | 15 |
| 2009-05-17 | vs BAL | 38 | W 7-4 | 18-20 | 2 | 22,791 | Luke Hochevar | Koji Uehara | Juan Cruz | Jim Johnson | | 173 | 155 | 18 |
| 2009-05-19 | vs CLE | 39 | W 6-5 | 19-20 | 2 | 25,024 | Brian Bannister | Cliff Lee | Kyle Farnsworth | Kerry Wood | | 179 | 160 | 19 |
| 2009-05-20 | vs CLE | 40 | L 5-6 | 19-21 | 2 | 19,652 | Gil Meche | Fausto Carmona | Aaron Laffey | Sidney Ponson | Kerry Wood | 184 | 166 | 18 |
| 2009-05-21 | vs CLE | 41 | L 3-8 | 19-22 | 2 | 23,095 | Zack Greinke | Carl Pavano | Carl Pavano | Horacio Ramirez | Rafael Betancourt | 187 | 174 | 13 |
| 2009-05-22 | @ SLN | 42 | L 0-5 | 19-23 | 2 | 43,429 | Kyle Davies | Todd Wellemeyer | Todd Wellemeyer | Kyle Davies | | 187 | 179 | 8 |
| 2009-05-23 | @ SLN | 43 | L 0-5 | 19-24 | 3 | 43,829 | Luke Hochevar | Kyle Lohse | Kyle Lohse | Luke Hochevar | | 187 | 184 | 3 |
| 2009-05-24 | @ SLN | 44 | W 3-2 | 20-24 | 3 | 44,213 | Brian Bannister | Joel Pineiro | Brian Bannister | Joel Pineiro | Juan Cruz | 190 | 186 | 4 |
| 2009-05-25 | vs DET | 45 | L 1-13 | 20-25 | 3 | 34,524 | Gil Meche | Justin Verlander | Justin Verlander | Gil Meche | | 191 | 199 | -8 |
| 2009-05-26 | vs DET | 46 | W 6-1 | 21-25 | 3 | 16,366 | Zack Greinke | Edwin Jackson | Zack Greinke | Edwin Jackson | | 197 | 200 | -3 |
| 2009-05-27 | vs DET | 47 | L 3-8 | 21-26 | 3 | 16,568 | Kyle Davies | Rick Porcello | Rick Porcello | Kyle Davies | | 200 | 208 | -8 |
| 2009-05-29 | vs CHA | 48 | L 2-11 | 22-26 | 3 | 26,495 | Brian Bannister | Clayton Richard | Clayton Richard | Brian Bannister | | 202 | 219 | -17 |
| 2009-05-30 | vs CHA | 49 | L 3-5 | 22-27 | 3 | 37,894 | Gil Meche | Mark Buehrle | Scott Linebrink | Juan Cruz | Bobby Jenks | 205 | 224 | -19 |
| 2009-05-31 | vs CHA | 50 | L 4-7 | 22-28 | 4 | 19,855 | Zack Greinke | John Danks | Matt Thornton | John Bale | Bobby Jenks | 209 | 231 | -22 |
| 2009-06-02 | @ TBA | 51 | L 2-6 | 22-29 | 4 | 13,604 | Kyle Davies | Andy Sonnanstine | Andy Sonnanstine | Kyle Davies | | 211 | 237 | -26 |
| 2009-06-03 | @ TBA | 52 | L 0-9 | 22-30 | 5 | 15,256 | Brian Bannister | Jeff Niemann | Jeff Niemann | Brian Bannister | | 211 | 246 | -35 |
| 2009-06-04 | @ TBA | 53 | L 2-3 | 22-31 | 5 | 16,103 | Gil Meche | James Shields | James Shields | Jamey Wright | J.P. Howell | 213 | 249 | -36 |
| 2009-06-05 | @ TOR | 54 | L 3-9 | 22-32 | 5 | 15,435 | Zack Greinke | Ricky Romero | Ricky Romero | Zack Greinke | | 216 | 258 | -42 |
| 2009-06-06 | @ TOR | 55 | W 6-2 | 23-32 | 5 | 16,552 | Luke Hochevar | Scott Richmond | Luke Hochevar | Scott Richmond | | 222 | 260 | -38 |
| 2009-06-07 | @ TOR | 56 | L 0-4 | 23-33 | 5 | 21,071 | Kyle Davies | Roy Halladay | Roy Halladay | Kyle Davies | | 222 | 264 | -42 |
| 2009-06-09 | @ CLE | 57 | L 4-8 | 23-34 | 5 | 15,038 | Brian Bannister | Cliff Lee | Rafael Perez | Juan Cruz | | 226 | 272 | -46 |
| 2009-06-10 | @ CLE | 58 | W 9-0 | 24-34 | 4 | 16,257 | Gil Meche | Carl Pavano | Gil Meche | Carl Pavano | | 235 | 272 | -37 |
| 2009-06-11 | @ CLE | 59 | L 3-4 | 24-35 | 5 | 14,342 | Zack Greinke | Jeremy Sowers | Matt Herges | Kyle Farnsworth | | 238 | 276 | -38 |
| 2009-06-12 | vs CIN | 60 | W 4-1 | 25-35 | 4 | 32,959 | Luke Hochevar | Matt Maloney | Luke Hochevar | Matt Maloney | | 242 | 277 | -35 |
| 2009-06-13 | vs CIN | 61 | W 7-4 | 26-35 | 4 | 29,574 | Kyle Davies | Bronson Arroyo | Kyle Davies | Bronson Arroyo | | 249 | 281 | -32 |
| 2009-06-14 | vs CIN | 62 | W 7-1 | 27-35 | 4 | 24,525 | Brian Bannister | Johnny Cueto | Brian Bannister | Johnny Cueto | | 256 | 282 | -26 |
| 2009-06-16 | vs ARI | 63 | W 5-0 | 28-35 | 4 | 26,974 | Gil Meche | Doug Davis | Gil Meche | Doug Davis | | 261 | 282 | -21 |
| 2009-06-17 | vs ARI | 64 | L 5-12 | 29-35 | 3 | 29,777 | Zack Greinke | Max Scherzer | Max Scherzer | Zack Greinke | | 266 | 294 | -28 |
| 2009-06-18 | vs ARI | 65 | L 5-12 | 30-35 | 2 | 14,129 | Luke Hochevar | Dan Haren | Dan Haren | Luke Hochevar | | 271 | 306 | -35 |
| 2009-06-19 | vs SLN | 66 | L 5-10 | 31-35 | 2 | 37,660 | Kyle Davies | Brad Thompson | Brad Thompson | Kyle Davies | | 276 | 316 | -40 |
| 2009-06-20 | vs SLN | 67 | L 1-7 | 31-36 | 2 | 38,769 | Brian Bannister | Chris Carpenter | Chris Carpenter | Brian Bannister | Ryan Franklin | 277 | 323 | -46 |
| 2009-06-21 | vs SLN | 68 | L 5-12 | 32-36 | 2 | 33,805 | Gil Meche | Adam Wainwright | Adam Wainwright | Gil Meche | | 282 | 335 | -53 |
| 2009-06-23 | @ HOU | 69 | W 2-1 | 33-36 | 2 | 30,049 | Zack Greinke | Russ Ortiz | Zack Greinke | Russ Ortiz | Joakim Soria | 284 | 336 | -52 |
| 2009-06-24 | @ HOU | 70 | W 4-3 | 34-36 | 2 | 28,602 | Luke Hochevar | Roy Oswalt | Joakim Soria | Jeff Fulchino | John Bale | 288 | 339 | -51 |
| 2009-06-25 | @ HOU | 71 | L 4-5 | 34-37 | 2 | 32,048 | Brian Bannister | Brian Moehler | Wesley Wright | Brian Bannister | Jose Valverde | 292 | 344 | -52 |
| 2009-06-26 | @ PIT | 72 | L 3-5 | 34-38 | 2 | 18,458 | Gil Meche | Virgil Vasquez | Virgil Vasquez | Gil Meche | Matt Capps | 295 | 349 | -54 |
| 2009-06-27 | @ PIT | 73 | L 2-6 | 34-39 | 2 | 36,032 | Bruce Chen | Paul Maholm | Paul Maholm | Bruce Chen | | 297 | 355 | -58 |
| 2009-06-28 | @ PIT | 74 | W 3-2 | 35-39 | 2 | 25,888 | Zack Greinke | Charlie Morton | Zack Greinke | Charlie Morton | Joakim Soria | 300 | 357 | -57 |
| 2009-06-29 | vs MIN | 75 | W 4-2 | 36-39 | 2 | 22,066 | Luke Hochevar | Nick Blackburn | Luke Hochevar | Nick Blackburn | Joakim Soria | 304 | 359 | -55 |
| 2009-06-30 | vs MIN | 76 | L 1-2 | 36-40 | 2 | 19,310 | Brian Bannister | Scott Baker | Scott Baker | Brian Bannister | Joe Nathan | 305 | 361 | -56 |
| 2009-07-01 | vs MIN | 77 | L 1-5 | 36-41 | 3 | 18,906 | Gil Meche | Glen Perkins | Glen Perkins | Gil Meche | Joe Nathan | 306 | 366 | -60 |
| 2009-07-02 | vs CHA | 78 | L 1-4 | 36-42 | 3 | 17,964 | Bruce Chen | Mark Buehrle | Mark Buehrle | Bruce Chen | Bobby Jenks | 307 | 370 | -63 |
| 2009-07-03 | vs CHA | 79 | L 0-5 | 36-43 | 3 | 39,026 | Zack Greinke | John Danks | John Danks | Zack Greinke | Scott Linebrink | 307 | 375 | -68 |
| 2009-07-04 | vs CHA | 80 | W 6-4 | 37-43 | 3 | 18,182 | Luke Hochevar | Gavin Floyd | Luke Hochevar | Gavin Floyd | Joakim Soria | 313 | 379 | -66 |
| 2009-07-05 | vs CHA | 81 | W 6-3 | 38-43 | 3 | 15,915 | Brian Bannister | Clayton Richard | Brian Bannister | Clayton Richard | Joakim Soria | 319 | 382 | -63 |
| 2009-07-06 | @ DET | 82 | W 4-3 | 39-43 | 3 | 32,134 | Gil Meche | Armando Galarraga | Roman Colon | Fernando Rodney | Joakim Soria | 323 | 385 | -62 |
| 2009-07-07 | @ DET | 83 | L 5-8 | 39-44 | 3 | 29,751 | Bruce Chen | Justin Verlander | Justin Verlander | Bruce Chen | Fernando Rodney | 328 | 393 | -65 |
| 2009-07-08 | @ DET | 84 | L 1-3 | 39-45 | 3 | 29,104 | Zack Greinke | Lucas French | Lucas French | Zack Greinke | Fernando Rodney | 329 | 396 | -67 |
| 2009-07-09 | @ BOS | 85 | W 8-6 | 40-45 | 3 | 38,189 | Luke Hochevar | Brad Penny | Luke Hochevar | Justin Masterson | Joakim Soria | 337 | 402 | -65 |
| 2009-07-10 | @ BOS | 86 | L 0-1 | 40-46 | 3 | 38,116 | Brian Bannister | Jon Lester | Jon Lester | Brian Bannister | Jonathan Papelbon | 337 | 403 | -66 |
| 2009-07-11 | @ BOS | 87 | L 9-15 | 41-46 | 3 | 37,825 | Gil Meche | John Smoltz | John Smoltz | Gil Meche | | 346 | 418 | -72 |
| 2009-07-12 | @ BOS | 88 | L 0-6 | 41-47 | 3 | 37,612 | Bruce Chen | Josh Beckett | Josh Beckett | Bruce Chen | | 346 | 424 | -78 |
| 2009-07-17 | vs TBA | 89 | L 7-8 | 41-48 | 3 | 33,568 | Brian Bannister | James Shields | Joe Nelson | Juan Cruz | J.P. Howell | 353 | 432 | -79 |
| 2009-07-18 | vs TBA | 90 | L 2-4 | 41-49 | 4 | 30,288 | Zack Greinke | Scott Kazmir | Chad Bradford | Juan Cruz | J.P. Howell | 355 | 436 | -81 |
| 2009-07-19 | vs TBA | 91 | L 3-4 | 41-50 | 4 | 18,934 | Luke Hochevar | Matt Garza | Grant Balfour | Jamey Wright | J.P. Howell | 358 | 440 | -82 |
| 2009-07-21 | vs ANA | 92 | L 5-8 | 41-51 | 5 | 0 | Sidney Ponson | Ervin Santana | Ervin Santana | Sidney Ponson | Brian Fuentes | 363 | 448 | -85 |
| 2009-07-21 | vs ANA | 93 | L 2-10 | 41-51 | 5 | 23,874 | Bruce Chen | Sean O'Sullivan | Sean O'Sullivan | Bruce Chen | | 365 | 458 | -93 |
| 2009-07-22 | vs ANA | 94 | L 6-9 | 42-52 | 4 | 18,078 | Brian Bannister | Joe Saunders | Justin Speier | Roman Colon | Brian Fuentes | 371 | 467 | -96 |
| 2009-07-24 | vs TEX | 95 | L 0-2 | 42-53 | 7 | 25,012 | Zack Greinke | Scott Feldman | Scott Feldman | Zack Greinke | C.J. Wilson | 371 | 469 | -98 |
| 2009-07-25 | vs TEX | 96 | W 6-3 | 43-53 | 4 | 27,602 | Luke Hochevar | Derek Holland | Luke Hochevar | Derek Holland | Joakim Soria | 377 | 472 | -95 |
| 2009-07-26 | vs TEX | 97 | L 2-7 | 43-54 | 4 | 16,847 | Sidney Ponson | Kevin Millwood | Dustin Nippert | Ron Mahay | | 379 | 479 | -100 |
| 2009-07-27 | @ BAL | 98 | W 5-3 | 44-54 | 4 | 15,169 | Bruce Chen | Rich Hill | Rob Tejeda | Matt Albers | Joakim Soria | 384 | 482 | -98 |
| 2009-07-28 | @ BAL | 99 | W 4-3 | 45-54 | 4 | 21,545 | Brian Bannister | Jason Berken | Jamey Wright | Danys Baez | Joakim Soria | 388 | 485 | -97 |
| 2009-07-29 | @ BAL | 100 | L 3-7 | 45-55 | 4 | 19,741 | Zack Greinke | Chris Tillman | Matt Albers | Rob Tejeda | Jim Johnson | 391 | 492 | -101 |
| 2009-07-30 | @ BAL | 101 | L 3-7 | 45-56 | 4 | 19,194 | Luke Hochevar | Brad Bergesen | Brad Bergesen | Luke Hochevar | | 394 | 499 | -105 |
| 2009-07-31 | @ TBA | 102 | L 2-8 | 45-57 | 4 | 26,596 | Sidney Ponson | David Price | David Price | Sidney Ponson | | 396 | 507 | -111 |
| 2009-08-01 | @ TBA | 103 | L 1-7 | 45-58 | 4 | 36,973 | Bruce Chen | Jeff Niemann | Jeff Niemann | Bruce Chen | | 397 | 514 | -117 |
| 2009-08-02 | @ TBA | 104 | W 4-1 | 46-58 | 4 | 27,930 | Brian Bannister | James Shields | Brian Bannister | James Shields | Joakim Soria | 401 | 515 | -114 |
| 2009-08-03 | @ TBA | 105 | L 4-10 | 47-58 | 3 | 24,219 | Zack Greinke | Scott Kazmir | Scott Kazmir | Zack Greinke | | 405 | 525 | -120 |
| 2009-08-04 | vs SEA | 106 | L 6-7 | 47-59 | 4 | 15,057 | Luke Hochevar | Ryan Rowland-Smith | Shawn Kelley | Jamey Wright | David Aardsma | 411 | 532 | -121 |
| 2009-08-05 | vs SEA | 107 | L 6-11 | 48-59 | 4 | 27,805 | Kyle Davies | Lucas French | Lucas French | Kyle Davies | | 417 | 543 | -126 |
| 2009-08-06 | vs SEA | 108 | W 8-2 | 49-59 | 3 | 15,103 | Bruce Chen | Jason Vargas | Bruce Chen | Jason Vargas | | 425 | 545 | -120 |
| 2009-08-07 | vs OAK | 109 | L 4-9 | 49-60 | 4 | 21,918 | Brian Bannister | Vin Mazzaro | Vin Mazzaro | Brian Bannister | | 429 | 554 | -125 |
| 2009-08-08 | vs OAK | 110 | W 12-6 | 49-61 | 5 | 29,818 | Zack Greinke | Clayton Mortenson | Zack Greinke | Clayton Mortenson | | 441 | 560 | -119 |
| 2009-08-09 | vs OAK | 111 | L 3-6 | 49-62 | 5 | 19,439 | Luke Hochevar | Brett Anderson | Brett Anderson | Luke Hochevar | Andrew Bailey | 444 | 566 | -122 |
| 2009-08-11 | @ MIN | 112 | W 14-6 | 49-63 | 5 | 32,121 | Kyle Davies | Nick Blackburn | Kyle Davies | Nick Blackburn | | 458 | 572 | -114 |
| 2009-08-12 | @ MIN | 113 | L 1-7 | 49-64 | 5 | 30,105 | Brian Bannister | Francisco Liriano | Francisco Liriano | Brian Bannister | | 459 | 579 | -120 |
| 2009-08-13 | @ MIN | 114 | W 5-4 | 50-64 | 5 | 32,373 | Gil Meche | Carl Pavano | Gil Meche | Carl Pavano | Joakim Soria | 464 | 583 | -119 |
| 2009-08-14 | @ DET | 115 | L 0-1 | 50-65 | 5 | 34,799 | Zack Greinke | Jarrod Washburn | Brandon Lyon | Roman Colon | | 464 | 584 | -120 |
| 2009-08-15 | @ DET | 116 | L 3-10 | 51-65 | 5 | 37,276 | Luke Hochevar | Edwin Jackson | Edwin Jackson | Luke Hochevar | | 467 | 594 | -127 |
| 2009-08-16 | @ DET | 117 | W 3-2 | 52-65 | 5 | 32,888 | Kyle Davies | Armando Galarraga | Joakim Soria | Fernando Rodney | | 470 | 596 | -126 |
| 2009-08-17 | @ CHA | 118 | L 7-8 | 52-66 | 5 | 36,703 | Brian Bannister | Mark Buehrle | Scott Linebrink | Roman Colon | Bobby Jenks | 477 | 604 | -127 |
| 2009-08-18 | @ CHA | 119 | W 5-4 | 53-66 | 5 | 28,812 | Gil Meche | Freddy Garcia | Gil Meche | Freddy Garcia | Joakim Soria | 482 | 608 | -126 |
| 2009-08-19 | @ CHA | 120 | L 2-4 | 53-67 | 5 | 25,786 | Zack Greinke | Jose Contreras | Jose Contreras | Zack Greinke | Bobby Jenks | 484 | 612 | -128 |
| 2009-08-21 | vs MIN | 121 | L 4-5 | 53-68 | 5 | 22,283 | Luke Hochevar | Nick Blackburn | Joe Nathan | Joakim Soria | | 488 | 617 | -129 |
| 2009-08-22 | vs MIN | 122 | L 7-8 | 53-69 | 5 | 33,811 | Kyle Davies | Brian Duensing | Brian Duensing | Kyle Davies | Matt Guerrier | 495 | 625 | -130 |
| 2009-08-23 | vs MIN | 123 | L 3-10 | 54-69 | 5 | 18,680 | Brian Bannister | Carl Pavano | Carl Pavano | Brian Bannister | | 498 | 635 | -137 |
| 2009-08-24 | vs CLE | 124 | L 6-10 | 55-69 | 5 | 11,101 | Gil Meche | Jeremy Sowers | Jeremy Sowers | Joakim Soria | | 504 | 645 | -141 |
| 2009-08-25 | vs CLE | 125 | W 6-2 | 56-69 | 4 | 17,353 | Zack Greinke | Justin Masterson | Zack Greinke | Justin Masterson | | 510 | 647 | -137 |
| 2009-08-26 | vs CLE | 126 | L 2-4 | 56-70 | 5 | 10,751 | Luke Hochevar | David Huff | David Huff | Luke Hochevar | Kerry Wood | 512 | 651 | -139 |
| 2009-08-27 | @ SEA | 127 | W 8-4 | 57-70 | 5 | 19,345 | Kyle Davies | Doug Fister | Kyle Davies | Doug Fister | | 520 | 655 | -135 |
| 2009-08-28 | @ SEA | 128 | L 3-6 | 57-71 | 5 | 26,714 | Brian Bannister | Felix Hernandez | Felix Hernandez | Brian Bannister | David Aardsma | 523 | 661 | -138 |
| 2009-08-29 | @ SEA | 129 | L 4-8 | 57-72 | 5 | 26,457 | Gil Meche | Ian Snell | Ian Snell | Gil Meche | | 527 | 669 | -142 |
| 2009-08-30 | @ SEA | 130 | W 3-0 | 58-72 | 4 | 30,286 | Zack Greinke | Ryan Rowland-Smith | Zack Greinke | Ryan Rowland-Smith | | 530 | 669 | -139 |
| 2009-08-31 | @ OAK | 131 | L 5-8 | 58-73 | 4 | 10,376 | Luke Hochevar | Gio Gonzalez | Craig Breslow | Luke Hochevar | Andrew Bailey | 535 | 677 | -142 |
| 2009-09-01 | @ OAK | 132 | W 4-3 | 59-73 | 4 | 10,039 | Kyle Davies | Edgar Gonzalez | Kyle Davies | Jay Marshall | Joakim Soria | 539 | 680 | -141 |
| 2009-09-02 | @ OAK | 133 | L 4-10 | 60-73 | 3 | 13,920 | Brian Bannister | Trevor Cahill | Trevor Cahill | Brian Bannister | | 543 | 690 | -147 |
| 2009-09-04 | vs ANA | 134 | L 1-2 | 60-74 | 4 | 17,447 | Rob Tejeda | Jered Weaver | Jered Weaver | Jamey Wright | Brian Fuentes | 544 | 692 | -148 |
| 2009-09-05 | vs ANA | 135 | L 1-2 | 60-75 | 5 | 22,628 | Zack Greinke | John Lackey | Kevin Jepsen | Yasuhiko Yabuta | Brian Fuentes | 545 | 694 | -149 |
| 2009-09-06 | vs ANA | 136 | L 2-7 | 60-76 | 5 | 16,745 | Luke Hochevar | Joe Saunders | Joe Saunders | Luke Hochevar | | 547 | 701 | -154 |
| 2009-09-07 | vs ANA | 137 | W 6-3 | 61-76 | 5 | 18,453 | Kyle Davies | Ervin Santana | Kyle Davies | Ervin Santana | Joakim Soria | 553 | 704 | -151 |
| 2009-09-08 | vs DET | 138 | W 7-5 | 62-76 | 6 | 12,032 | Bruce Chen | Rick Porcello | Yasuhiko Yabuta | Bobby Seay | Joakim Soria | 560 | 709 | -149 |
| 2009-09-09 | vs DET | 139 | W 5-1 | 63-76 | 5 | 10,584 | Rob Tejeda | Justin Verlander | Rob Tejeda | Justin Verlander | Joakim Soria | 565 | 710 | -145 |
| 2009-09-10 | vs DET | 140 | W 7-4 | 64-76 | 3 | 12,029 | Lenny DiNardo | Jarrod Washburn | Roman Colon | Zach Miner | Carlos Rosa | 572 | 714 | -142 |
| 2009-09-11 | @ CLE | 141 | W 2-1 | 65-76 | 3 | 26,006 | Zack Greinke | Justin Masterson | Jamey Wright | Jose Veras | Joakim Soria | 574 | 715 | -141 |
| 2009-09-12 | @ CLE | 142 | L 6-13 | 66-76 | 3 | 24,842 | Luke Hochevar | David Huff | David Huff | Luke Hochevar | | 580 | 728 | -148 |
| 2009-09-13 | @ CLE | 143 | W 7-0 | 67-76 | 3 | 21,153 | Kyle Davies | Carlos Carrasco | Kyle Davies | Carlos Carrasco | | 587 | 728 | -141 |
| 2009-09-15 | @ DET | 144 | W 11-1 | 68-76 | 3 | 20,422 | Rob Tejeda | Jarrod Washburn | Rob Tejeda | Jarrod Washburn | | 598 | 729 | -131 |
| 2009-09-16 | @ DET | 145 | L 3-4 | 68-77 | 3 | 25,400 | Lenny DiNardo | Eddie Bonine | Zach Miner | Lenny DiNardo | Fernando Rodney | 601 | 733 | -132 |
| 2009-09-17 | @ DET | 146 | W 9-2 | 69-77 | 3 | 26,457 | Zack Greinke | Edwin Jackson | Zack Greinke | Edwin Jackson | | 610 | 735 | -125 |
| 2009-09-18 | @ CHA | 147 | W 11-0 | 70-77 | 3 | 29,179 | Luke Hochevar | Mark Buehrle | Luke Hochevar | Mark Buehrle | | 621 | 735 | -114 |
| 2009-09-19 | @ CHA | 148 | L 3-13 | 71-77 | 3 | 28,329 | Dusty Hughes | Jake Peavy | Jake Peavy | Dusty Hughes | | 624 | 748 | -124 |
| 2009-09-20 | @ CHA | 149 | W 2-1 | 72-77 | 3 | 22,798 | Rob Tejeda | Freddy Garcia | Rob Tejeda | Freddy Garcia | Joakim Soria | 626 | 749 | -123 |
| 2009-09-21 | vs BOS | 150 | W 12-9 | 72-78 | 3 | 16,770 | Lenny DiNardo | Tim Wakefield | Yasuhiko Yabuta | Daniel Bard | Joakim Soria | 638 | 758 | -120 |
| 2009-09-22 | vs BOS | 151 | W 5-1 | 73-78 | 3 | 21,228 | Zack Greinke | Paul Byrd | Zack Greinke | Paul Byrd | Joakim Soria | 643 | 759 | -116 |
| 2009-09-23 | vs BOS | 152 | L 2-9 | 73-79 | 3 | 18,989 | Luke Hochevar | Josh Beckett | Josh Beckett | Luke Hochevar | | 645 | 768 | -123 |
| 2009-09-24 | vs BOS | 153 | L 3-10 | 74-79 | 3 | 20,807 | Anthony Lerew | Clay Buchholz | Clay Buchholz | Anthony Lerew | | 648 | 778 | -130 |
| 2009-09-25 | vs MIN | 154 | L 4-9 | 74-80 | 3 | 23,307 | Rob Tejeda | Carl Pavano | Carl Pavano | Rob Tejeda | | 652 | 787 | -135 |
| 2009-09-26 | vs MIN | 155 | L 6-11 | 75-80 | 3 | 30,690 | Lenny DiNardo | Scott Baker | Scott Baker | Lenny DiNardo | | 658 | 798 | -140 |
| 2009-09-27 | vs MIN | 156 | W 4-1 | 76-80 | 3 | 28,721 | Zack Greinke | Francisco Liriano | Zack Greinke | Francisco Liriano | Joakim Soria | 662 | 799 | -137 |
| 2009-09-28 | @ NYA | 157 | L 2-8 | 76-81 | 3 | 45,348 | Luke Hochevar | Chad Gaudin | Chad Gaudin | Luke Hochevar | | 664 | 807 | -143 |
| 2009-09-29 | @ NYA | 158 | L 3-4 | 76-82 | 5 | 44,794 | Anthony Lerew | A.J. Burnett | Brian Bruney | Kyle Farnsworth | | 667 | 811 | -144 |
| 2009-09-30 | @ NYA | 159 | W 4-3 | 77-82 | 3 | 46,956 | Rob Tejeda | Joba Chamberlain | Jamey Wright | Damaso Marte | Joakim Soria | 671 | 814 | -143 |
| 2009-10-02 | @ MIN | 160 | L 7-10 | 78-82 | 3 | 40,223 | Lenny DiNardo | Jeff Manship | Jeff Manship | Lenny DiNardo | Joe Nathan | 678 | 824 | -146 |
| 2009-10-03 | @ MIN | 161 | L 4-5 | 78-83 | 3 | 48,644 | Zack Greinke | Nick Blackburn | Jon Rauch | Dusty Hughes | Joe Nathan | 682 | 829 | -147 |
| 2009-10-04 | @ MIN | 162 | L 4-13 | 79-83 | 3 | 51,155 | Luke Hochevar | Carl Pavano | Carl Pavano | Luke Hochevar | | 686 | 842 | -156 |