| 2009-04-06 | vs CHN | 1 | L 2-4 | - | | 43,827 | Roy Oswalt | Carlos Zambrano | Carlos Zambrano | Roy Oswalt | Kevin Gregg | 2 | 4 | -2 |
| 2009-04-07 | vs CHN | 2 | W 3-2 | - | | 31,121 | Wandy Rodriguez | Ryan Dempster | Doug Brocail | Neal Cotts | | 5 | 6 | -1 |
| 2009-04-08 | vs CHN | 3 | L 6-11 | - | | 30,047 | Brian Moehler | Ted Lilly | Ted Lilly | Brian Moehler | | 11 | 17 | -6 |
| 2009-04-10 | @ SLN | 4 | L 3-5 | - | | 37,224 | Mike Hampton | Joel Pineiro | Joel Pineiro | Mike Hampton | Kyle McClellan | 14 | 22 | -8 |
| 2009-04-11 | @ SLN | 5 | L 2-11 | - | | 43,454 | Roy Oswalt | Adam Wainwright | Adam Wainwright | Roy Oswalt | | 16 | 33 | -17 |
| 2009-04-12 | @ SLN | 6 | L 0-3 | - | | 36,310 | Wandy Rodriguez | Kyle Lohse | Kyle Lohse | Wandy Rodriguez | | 16 | 36 | -20 |
| 2009-04-13 | @ PIT | 7 | L 0-7 | - | | 38,411 | Brian Moehler | Zach Duke | Zach Duke | Brian Moehler | | 16 | 43 | -27 |
| 2009-04-15 | @ PIT | 8 | W 4-1 | - | | 20,690 | Mike Hampton | Ross Ohlendorf | Mike Hampton | Ross Ohlendorf | | 20 | 44 | -24 |
| 2009-04-16 | @ PIT | 9 | W 6-3 | - | | 13,877 | Russ Ortiz | Jeff Karstens | Wesley Wright | Sean Burnett | LaTroy Hawkins | 26 | 47 | -21 |
| 2009-04-17 | vs CIN | 10 | L 1-2 | - | | 32,268 | Roy Oswalt | Johnny Cueto | Nick Masset | Jose Valverde | Francisco Cordero | 27 | 49 | -22 |
| 2009-04-18 | vs CIN | 11 | W 7-0 | - | | 30,141 | Wandy Rodriguez | Aaron Harang | Wandy Rodriguez | Aaron Harang | | 34 | 49 | -15 |
| 2009-04-19 | vs CIN | 12 | L 2-4 | - | | 29,372 | Felipe Paulino | Edinson Volquez | Edinson Volquez | Geoff Geary | Francisco Cordero | 36 | 53 | -17 |
| 2009-04-20 | vs CIN | 13 | L 3-4 | - | | 23,308 | Mike Hampton | Bronson Arroyo | Bronson Arroyo | Geoff Geary | Francisco Cordero | 39 | 57 | -18 |
| 2009-04-21 | vs LAN | 14 | W 8-5 | - | | 26,360 | Russ Ortiz | Clayton Kershaw | Russ Ortiz | Clayton Kershaw | Jose Valverde | 47 | 62 | -15 |
| 2009-04-22 | vs LAN | 15 | W 6-5 | - | | 26,725 | Roy Oswalt | Randy Wolf | Chris Sampson | Ronald Belisario | LaTroy Hawkins | 53 | 67 | -14 |
| 2009-04-23 | vs LAN | 16 | L 0-2 | - | | 26,081 | Wandy Rodriguez | Chad Billingsley | Chad Billingsley | Wandy Rodriguez | Jonathan Broxton | 53 | 69 | -16 |
| 2009-04-24 | vs MIL | 17 | L 2-5 | - | | 25,316 | Felipe Paulino | Yovani Gallardo | Yovani Gallardo | Felipe Paulino | | 55 | 74 | -19 |
| 2009-04-25 | vs MIL | 18 | L 8-9 | - | | 31,355 | Mike Hampton | Jeff Suppan | Mark DiFelice | Geoff Geary | | 63 | 83 | -20 |
| 2009-04-26 | vs MIL | 19 | W 3-2 | - | | 27,690 | Russ Ortiz | Manny Parra | Russ Ortiz | Manny Parra | Jose Valverde | 66 | 85 | -19 |
| 2009-04-27 | @ CIN | 20 | W 4-1 | - | | 12,365 | Roy Oswalt | Johnny Cueto | Chris Sampson | Francisco Cordero | | 70 | 86 | -16 |
| 2009-04-28 | @ CIN | 21 | W 8-3 | - | | 9,878 | Wandy Rodriguez | Aaron Harang | Wandy Rodriguez | Aaron Harang | | 78 | 89 | -11 |
| 2009-04-29 | @ CIN | 22 | L 0-3 | - | | 12,681 | Felipe Paulino | Edinson Volquez | Edinson Volquez | Felipe Paulino | Francisco Cordero | 78 | 92 | -14 |
| 2009-05-01 | @ ATL | 23 | L 2-7 | - | | 29,309 | Mike Hampton | Derek Lowe | Derek Lowe | Mike Hampton | | 80 | 99 | -19 |
| 2009-05-02 | @ ATL | 24 | W 5-1 | - | | 28,203 | Roy Oswalt | Jair Jurrjens | Felipe Paulino | Buddy Carlyle | | 85 | 100 | -15 |
| 2009-05-03 | @ ATL | 25 | W 7-5 | - | | 27,921 | Wandy Rodriguez | Jo-Jo Reyes | Geoff Geary | Peter Moylan | LaTroy Hawkins | 92 | 105 | -13 |
| 2009-05-04 | @ WAS | 26 | L 4-9 | - | | 14,115 | Brian Moehler | John Lannan | John Lannan | Wesley Wright | | 96 | 114 | -18 |
| 2009-05-05 | @ WAS | 27 | L 10-11 | - | | 19,328 | Roy Oswalt | Scott Olsen | Joel Hanrahan | LaTroy Hawkins | | 106 | 125 | -19 |
| 2009-05-06 | vs CHN | 28 | L 3-6 | - | | 29,415 | Mike Hampton | Rich Harden | Rich Harden | Mike Hampton | Kevin Gregg | 109 | 131 | -22 |
| 2009-05-07 | vs CHN | 29 | L 5-8 | - | | 28,625 | Russ Ortiz | Ted Lilly | Ted Lilly | Russ Ortiz | | 114 | 139 | -25 |
| 2009-05-08 | vs SDN | 30 | W 2-0 | - | | 28,139 | Wandy Rodriguez | Chad Gaudin | Wandy Rodriguez | Chad Gaudin | LaTroy Hawkins | 116 | 139 | -23 |
| 2009-05-09 | vs SDN | 31 | W 5-4 | - | | 29,141 | Brian Moehler | Kevin Correia | LaTroy Hawkins | Luke Gregerson | | 121 | 143 | -22 |
| 2009-05-10 | vs SDN | 32 | W 12-5 | - | | 30,023 | Roy Oswalt | Josh Geer | Roy Oswalt | Josh Geer | | 133 | 148 | -15 |
| 2009-05-12 | @ COL | 33 | L 1-12 | - | | 23,233 | Felipe Paulino | Ubaldo Jimenez | Ubaldo Jimenez | Felipe Paulino | | 134 | 160 | -26 |
| 2009-05-13 | @ COL | 34 | W 15-11 | - | | 19,226 | Mike Hampton | Jason Marquis | Mike Hampton | Jason Marquis | | 149 | 171 | -22 |
| 2009-05-14 | @ COL | 35 | W 5-3 | - | | 22,696 | Wandy Rodriguez | Jason Hammel | Wandy Rodriguez | Jason Hammel | LaTroy Hawkins | 154 | 174 | -20 |
| 2009-05-16 | @ CHN | 36 | L 4-5 | - | | 40,549 | Roy Oswalt | Randy Wells | Sean Marshall | LaTroy Hawkins | | 158 | 179 | -21 |
| 2009-05-17 | @ CHN | 37 | W 6-5 | - | | 40,478 | Brian Moehler | Rich Harden | Brian Moehler | Rich Harden | Chris Sampson | 164 | 184 | -20 |
| 2009-05-19 | vs MIL | 38 | L 2-4 | - | | 29,343 | Mike Hampton | David Bush | David Bush | Russ Ortiz | Trevor Hoffman | 166 | 188 | -22 |
| 2009-05-20 | vs MIL | 39 | W 6-4 | - | | 27,160 | Wandy Rodriguez | Yovani Gallardo | Wandy Rodriguez | Yovani Gallardo | Chris Sampson | 172 | 192 | -20 |
| 2009-05-21 | vs MIL | 40 | L 3-4 | - | | 25,037 | Roy Oswalt | Jeff Suppan | Seth McClung | Jeff Fulchino | Trevor Hoffman | 175 | 196 | -21 |
| 2009-05-22 | vs TEX | 41 | L 5-6 | - | | 36,017 | Felipe Paulino | Derek Holland | Darren O'Day | LaTroy Hawkins | Frank Francisco | 180 | 202 | -22 |
| 2009-05-23 | vs TEX | 42 | L 3-6 | - | | 36,019 | Brian Moehler | Scott Feldman | Scott Feldman | Brian Moehler | C.J. Wilson | 183 | 208 | -25 |
| 2009-05-24 | vs TEX | 43 | L 0-5 | - | | 36,749 | Mike Hampton | Brandon McCarthy | Brandon McCarthy | Mike Hampton | | 183 | 213 | -30 |
| 2009-05-25 | @ CIN | 44 | L 5-8 | - | | 17,818 | Wandy Rodriguez | Aaron Harang | Aaron Harang | Wandy Rodriguez | Francisco Cordero | 188 | 221 | -33 |
| 2009-05-26 | @ CIN | 45 | L 4-6 | - | | 15,619 | Roy Oswalt | Micah Owings | Nick Masset | Tim Byrdak | Francisco Cordero | 192 | 227 | -35 |
| 2009-05-27 | @ CIN | 46 | L 1-6 | - | | 17,602 | Felipe Paulino | Bronson Arroyo | Bronson Arroyo | Felipe Paulino | | 193 | 233 | -40 |
| 2009-05-29 | @ PIT | 47 | W 6-1 | - | | 18,236 | Brian Moehler | Ross Ohlendorf | Brian Moehler | Ross Ohlendorf | | 199 | 234 | -35 |
| 2009-05-30 | @ PIT | 48 | L 4-7 | - | | 37,167 | Wandy Rodriguez | Jeff Karstens | Jeff Karstens | Wandy Rodriguez | Matt Capps | 203 | 241 | -38 |
| 2009-05-31 | @ PIT | 49 | W 2-1 | - | | 19,566 | Mike Hampton | Paul Maholm | Mike Hampton | Paul Maholm | LaTroy Hawkins | 205 | 242 | -37 |
| 2009-06-01 | vs COL | 50 | W 4-1 | - | | 24,016 | Roy Oswalt | Aaron Cook | Roy Oswalt | Aaron Cook | LaTroy Hawkins | 209 | 243 | -34 |
| 2009-06-02 | vs COL | 51 | W 3-2 | - | | 24,041 | Felipe Paulino | Ubaldo Jimenez | Russ Ortiz | Josh Fogg | | 212 | 245 | -33 |
| 2009-06-03 | vs COL | 52 | W 6-4 | - | | 22,032 | Brian Moehler | Jason Marquis | Tim Byrdak | Jason Marquis | Chris Sampson | 218 | 249 | -31 |
| 2009-06-04 | vs COL | 53 | L 3-10 | - | | 26,671 | Wandy Rodriguez | Jason Hammel | Jason Hammel | Wandy Rodriguez | | 221 | 259 | -38 |
| 2009-06-05 | vs PIT | 54 | W 9-1 | - | | 26,222 | Mike Hampton | Jeff Karstens | Mike Hampton | Jeff Karstens | | 230 | 260 | -30 |
| 2009-06-06 | vs PIT | 55 | L 4-6 | - | | 26,099 | Roy Oswalt | Paul Maholm | Paul Maholm | Roy Oswalt | Matt Capps | 234 | 266 | -32 |
| 2009-06-07 | vs PIT | 56 | W 6-4 | - | | 25,729 | Felipe Paulino | Ian Snell | Jeff Fulchino | Steven Jackson | LaTroy Hawkins | 240 | 270 | -30 |
| 2009-06-09 | vs CHN | 57 | L 1-7 | - | | 29,669 | Brian Moehler | Ted Lilly | Ted Lilly | Brian Moehler | | 241 | 277 | -36 |
| 2009-06-10 | vs CHN | 58 | W 2-1 | - | | 29,840 | Wandy Rodriguez | Carlos Zambrano | Chris Sampson | Angel Guzman | | 243 | 278 | -35 |
| 2009-06-11 | vs CHN | 59 | W 2-1 | - | | 34,250 | Russ Ortiz | Ryan Dempster | Jeff Fulchino | Jose Ascanio | | 245 | 279 | -34 |
| 2009-06-12 | @ ARI | 60 | L 1-8 | - | | 22,225 | Mike Hampton | Dan Haren | Dan Haren | Mike Hampton | | 246 | 287 | -41 |
| 2009-06-13 | @ ARI | 61 | W 6-4 | - | | 29,206 | Roy Oswalt | Jon Garland | Roy Oswalt | Jon Garland | LaTroy Hawkins | 252 | 291 | -39 |
| 2009-06-14 | @ ARI | 62 | W 8-3 | - | | 26,937 | Brian Moehler | Billy Buckner | Brian Moehler | Billy Buckner | | 260 | 294 | -34 |
| 2009-06-16 | @ TEX | 63 | L 1-6 | - | | 21,676 | Wandy Rodriguez | Kevin Millwood | Kevin Millwood | Wandy Rodriguez | | 261 | 300 | -39 |
| 2009-06-17 | @ TEX | 64 | L 4-5 | - | | 32,425 | Russ Ortiz | Matt Harrison | C.J. Wilson | Jeff Fulchino | | 265 | 305 | -40 |
| 2009-06-18 | @ TEX | 65 | W 5-3 | - | | 25,445 | Brandon Backe | Vicente Padilla | Alberto Arias | Jason Jennings | Jose Valverde | 270 | 308 | -38 |
| 2009-06-19 | @ MIN | 66 | L 2-5 | - | | 32,218 | Roy Oswalt | Kevin Slowey | Kevin Slowey | Roy Oswalt | Joe Nathan | 272 | 313 | -41 |
| 2009-06-20 | @ MIN | 67 | W 6-5 | - | | 34,710 | Brian Moehler | Scott Baker | Brian Moehler | Sean Henn | Jose Valverde | 278 | 318 | -40 |
| 2009-06-21 | @ MIN | 68 | W 4-1 | - | | 39,659 | Wandy Rodriguez | Glen Perkins | Wandy Rodriguez | Glen Perkins | Jose Valverde | 282 | 319 | -37 |
| 2009-06-23 | vs KCA | 69 | L 1-2 | - | | 30,049 | Russ Ortiz | Zack Greinke | Zack Greinke | Russ Ortiz | Joakim Soria | 283 | 321 | -38 |
| 2009-06-24 | vs KCA | 70 | L 3-4 | - | | 28,602 | Roy Oswalt | Luke Hochevar | Joakim Soria | Jeff Fulchino | John Bale | 286 | 325 | -39 |
| 2009-06-25 | vs KCA | 71 | W 5-4 | - | | 32,048 | Brian Moehler | Brian Bannister | Wesley Wright | Brian Bannister | Jose Valverde | 291 | 329 | -38 |
| 2009-06-26 | vs DET | 72 | W 5-4 | - | | 33,052 | Wandy Rodriguez | Justin Verlander | Chris Sampson | Joel Zumaya | LaTroy Hawkins | 296 | 333 | -37 |
| 2009-06-27 | vs DET | 73 | W 8-1 | - | | 37,123 | Felipe Paulino | Alfredo Figaro | Felipe Paulino | Alfredo Figaro | | 304 | 334 | -30 |
| 2009-06-28 | vs DET | 74 | L 3-4 | - | | 34,041 | Russ Ortiz | Edwin Jackson | Bobby Seay | Jose Valverde | Fernando Rodney | 307 | 338 | -31 |
| 2009-06-29 | @ SDN | 75 | W 3-1 | - | | 15,671 | Roy Oswalt | Josh Geer | Roy Oswalt | Josh Geer | | 310 | 339 | -29 |
| 2009-06-30 | @ SDN | 76 | L 3-4 | - | | 15,276 | Mike Hampton | Josh Banks | Josh Banks | Chris Sampson | Heath Bell | 313 | 343 | -30 |
| 2009-07-01 | @ SDN | 77 | W 7-1 | - | | 16,670 | Brian Moehler | Walter Silva | Brian Moehler | Walter Silva | | 320 | 344 | -24 |
| 2009-07-02 | @ SDN | 78 | W 7-2 | - | | 23,284 | Wandy Rodriguez | Kevin Correia | Wandy Rodriguez | Kevin Correia | | 327 | 346 | -19 |
| 2009-07-03 | @ SFN | 79 | L 0-13 | - | | 42,199 | Felipe Paulino | Ryan Sadowski | Ryan Sadowski | Felipe Paulino | | 327 | 359 | -32 |
| 2009-07-04 | @ SFN | 80 | L 0-9 | - | | 34,582 | Russ Ortiz | Tim Lincecum | Tim Lincecum | Russ Ortiz | | 327 | 368 | -41 |
| 2009-07-05 | @ SFN | 81 | W 7-1 | - | | 30,157 | Roy Oswalt | Randy Johnson | Roy Oswalt | Randy Johnson | | 334 | 369 | -35 |
| 2009-07-06 | vs PIT | 82 | W 4-1 | - | | 26,834 | Mike Hampton | Virgil Vasquez | Mike Hampton | Virgil Vasquez | Jose Valverde | 338 | 370 | -32 |
| 2009-07-07 | vs PIT | 83 | L 3-6 | - | | 27,142 | Brian Moehler | Paul Maholm | Paul Maholm | Brian Moehler | Matt Capps | 341 | 376 | -35 |
| 2009-07-08 | vs PIT | 84 | W 5-0 | - | | 29,243 | Wandy Rodriguez | Charlie Morton | Wandy Rodriguez | Charlie Morton | | 346 | 376 | -30 |
| 2009-07-09 | vs WAS | 85 | W 9-4 | - | | 25,490 | Russ Ortiz | John Lannan | Alberto Arias | John Lannan | | 355 | 380 | -25 |
| 2009-07-10 | vs WAS | 86 | W 6-5 | - | | 33,085 | Roy Oswalt | Scott Olsen | Jeff Fulchino | Joe Beimel | | 361 | 385 | -24 |
| 2009-07-11 | vs WAS | 87 | L 2-13 | - | | 30,052 | Mike Hampton | Craig Stammen | Craig Stammen | Mike Hampton | | 363 | 398 | -35 |
| 2009-07-12 | vs WAS | 88 | W 5-0 | - | | 28,680 | Brian Moehler | Jordan Zimmermann | Brian Moehler | Jordan Zimmermann | Jose Valverde | 368 | 398 | -30 |
| 2009-07-16 | @ LAN | 89 | W 3-0 | - | | 45,970 | Wandy Rodriguez | Randy Wolf | Wandy Rodriguez | Randy Wolf | Jose Valverde | 371 | 398 | -27 |
| 2009-07-17 | @ LAN | 90 | W 8-1 | - | | 51,209 | Roy Oswalt | Chad Billingsley | Roy Oswalt | Chad Billingsley | | 379 | 399 | -20 |
| 2009-07-18 | @ LAN | 91 | L 2-5 | - | | 48,298 | Mike Hampton | Clayton Kershaw | Clayton Kershaw | Mike Hampton | Jonathan Broxton | 381 | 404 | -23 |
| 2009-07-19 | @ LAN | 92 | L 3-4 | - | | 40,340 | Russ Ortiz | Hiroki Kuroda | Ramon Troncoso | LaTroy Hawkins | Jonathan Broxton | 384 | 408 | -24 |
| 2009-07-20 | vs SLN | 93 | W 3-2 | - | | 36,437 | Brian Moehler | Kyle Lohse | Brian Moehler | Kyle Lohse | Jose Valverde | 387 | 410 | -23 |
| 2009-07-21 | vs SLN | 94 | W 11-6 | - | | 33,140 | Wandy Rodriguez | Todd Wellemeyer | Wandy Rodriguez | Todd Wellemeyer | | 398 | 416 | -18 |
| 2009-07-22 | vs SLN | 95 | W 4-3 | - | | 37,619 | Roy Oswalt | Chris Carpenter | Jose Valverde | Ryan Franklin | | 402 | 419 | -17 |
| 2009-07-24 | vs NYN | 96 | W 5-4 | - | | 42,967 | Mike Hampton | Johan Santana | Mike Hampton | Johan Santana | Jose Valverde | 407 | 423 | -16 |
| 2009-07-25 | vs NYN | 97 | L 3-10 | - | | 43,302 | Russ Ortiz | Jonathon Niese | Jonathon Niese | Russ Ortiz | | 410 | 433 | -23 |
| 2009-07-26 | vs NYN | 98 | L 3-8 | - | | 34,642 | Brian Moehler | Livan Hernandez | Livan Hernandez | Brian Moehler | Sean Green | 413 | 441 | -28 |
| 2009-07-27 | @ CHN | 99 | L 1-5 | - | | 40,794 | Wandy Rodriguez | Carlos Zambrano | Jeff Samardzija | Chris Sampson | | 414 | 446 | -32 |
| 2009-07-28 | @ CHN | 100 | W 11-6 | - | | 40,814 | Roy Oswalt | Ryan Dempster | Jeff Fulchino | Angel Guzman | | 425 | 452 | -27 |
| 2009-07-29 | @ CHN | 101 | L 0-12 | - | | 41,538 | Mike Hampton | Randy Wells | Randy Wells | Mike Hampton | | 425 | 464 | -39 |
| 2009-07-30 | @ CHN | 102 | L 3-12 | - | | 41,524 | Russ Ortiz | Kevin Hart | Kevin Hart | Russ Ortiz | | 428 | 476 | -48 |
| 2009-07-31 | @ SLN | 103 | L 3-4 | - | | 43,760 | Brian Moehler | Mitchell Boggs | Trever Miller | Alberto Arias | Ryan Franklin | 431 | 480 | -49 |
| 2009-08-01 | @ SLN | 104 | L 1-3 | - | | 45,074 | Wandy Rodriguez | Chris Carpenter | Chris Carpenter | Jeff Fulchino | | 432 | 483 | -51 |
| 2009-08-02 | @ SLN | 105 | W 2-0 | - | | 45,227 | Bud Norris | Adam Wainwright | Bud Norris | Adam Wainwright | Jose Valverde | 434 | 483 | -49 |
| 2009-08-03 | vs SFN | 106 | W 4-3 | - | | 29,835 | Mike Hampton | Matt Cain | Mike Hampton | Matt Cain | Jose Valverde | 438 | 486 | -48 |
| 2009-08-04 | vs SFN | 107 | L 1-8 | - | | 29,747 | Felipe Paulino | Jonathan Sanchez | Jonathan Sanchez | Felipe Paulino | | 439 | 494 | -55 |
| 2009-08-05 | vs SFN | 108 | L 6-10 | - | | 31,710 | Brian Moehler | Joe Martinez | Joe Martinez | Brian Moehler | | 445 | 504 | -59 |
| 2009-08-07 | vs MIL | 109 | W 6-3 | - | | 34,691 | Bud Norris | Carlos Villanueva | Bud Norris | Carlos Villanueva | Jose Valverde | 451 | 507 | -56 |
| 2009-08-08 | vs MIL | 110 | L 5-12 | - | | 35,216 | Mike Hampton | Manny Parra | Manny Parra | Mike Hampton | | 456 | 519 | -63 |
| 2009-08-09 | vs MIL | 111 | W 2-0 | - | | 32,262 | Wandy Rodriguez | Yovani Gallardo | Wandy Rodriguez | Yovani Gallardo | Jose Valverde | 458 | 519 | -61 |
| 2009-08-10 | @ FLO | 112 | L 6-8 | - | | 12,325 | Brian Moehler | Rick Vanden Hurk | Rick Vanden Hurk | Brian Moehler | Leo Nunez | 464 | 527 | -63 |
| 2009-08-11 | @ FLO | 113 | L 8-9 | - | | 13,312 | Roy Oswalt | Chris Volstad | Brian Sanches | Wesley Wright | | 472 | 536 | -64 |
| 2009-08-12 | @ FLO | 114 | W 14-6 | - | | 21,122 | Bud Norris | Ricky Nolasco | Bud Norris | Ricky Nolasco | | 486 | 542 | -56 |
| 2009-08-13 | @ FLO | 115 | L 2-9 | - | | 14,047 | Mike Hampton | Sean West | Sean West | Mike Hampton | | 488 | 551 | -63 |
| 2009-08-14 | @ MIL | 116 | L 2-11 | - | | 37,715 | Wandy Rodriguez | Yovani Gallardo | Yovani Gallardo | Wandy Rodriguez | | 490 | 562 | -72 |
| 2009-08-15 | @ MIL | 117 | L 2-6 | - | | 42,952 | Brian Moehler | Mike Burns | Mike Burns | Brian Moehler | | 492 | 568 | -76 |
| 2009-08-16 | @ MIL | 118 | W 8-5 | - | | 41,863 | Roy Oswalt | Braden Looper | Jeff Fulchino | David Weathers | Jose Valverde | 500 | 573 | -73 |
| 2009-08-18 | vs FLO | 119 | L 2-6 | - | | 30,189 | Bud Norris | Ricky Nolasco | Ricky Nolasco | Bud Norris | | 502 | 579 | -77 |
| 2009-08-19 | vs FLO | 120 | W 6-3 | - | | 30,101 | Yorman Bazardo | Sean West | Samuel Gervacio | Sean West | Jose Valverde | 508 | 582 | -74 |
| 2009-08-20 | vs FLO | 121 | W 4-1 | - | | 30,039 | Wandy Rodriguez | Josh Johnson | Wandy Rodriguez | Josh Johnson | Jose Valverde | 512 | 583 | -71 |
| 2009-08-21 | vs ARI | 122 | W 1-0 | - | | 30,032 | Roy Oswalt | Yusmeiro Petit | Roy Oswalt | Yusmeiro Petit | Jose Valverde | 513 | 583 | -70 |
| 2009-08-22 | vs ARI | 123 | W 4-2 | - | | 39,412 | Brian Moehler | Max Scherzer | Brian Moehler | Max Scherzer | LaTroy Hawkins | 517 | 585 | -68 |
| 2009-08-23 | vs ARI | 124 | L 5-7 | - | | 30,612 | Bud Norris | Jon Garland | Jon Garland | Bud Norris | Chad Qualls | 522 | 592 | -70 |
| 2009-08-25 | @ SLN | 125 | L 0-1 | - | | 40,512 | Wandy Rodriguez | Adam Wainwright | Adam Wainwright | Wandy Rodriguez | Ryan Franklin | 522 | 593 | -71 |
| 2009-08-26 | @ SLN | 126 | L 2-3 | - | | 40,311 | Roy Oswalt | Joel Pineiro | Joel Pineiro | Roy Oswalt | Ryan Franklin | 524 | 596 | -72 |
| 2009-08-27 | @ SLN | 127 | W 4-3 | - | | 40,348 | Brian Moehler | Chris Carpenter | Jose Valverde | Kyle McClellan | | 528 | 599 | -71 |
| 2009-08-28 | @ ARI | 128 | L 7-14 | - | | 26,190 | Yorman Bazardo | Max Scherzer | Max Scherzer | Yorman Bazardo | | 535 | 613 | -78 |
| 2009-08-29 | @ ARI | 129 | L 0-9 | - | | 37,190 | Bud Norris | Jon Garland | Jon Garland | Bud Norris | | 535 | 622 | -87 |
| 2009-08-30 | @ ARI | 130 | L 3-4 | - | | 29,062 | Wandy Rodriguez | Dan Haren | Dan Haren | Wandy Rodriguez | Chad Qualls | 538 | 626 | -88 |
| 2009-08-31 | @ CHN | 131 | W 5-3 | - | | 36,990 | Roy Oswalt | Rich Harden | Roy Oswalt | Rich Harden | Jose Valverde | 543 | 629 | -86 |
| 2009-09-01 | @ CHN | 132 | L 1-4 | - | | 36,332 | Brian Moehler | Randy Wells | Randy Wells | Brian Moehler | Carlos Marmol | 544 | 633 | -89 |
| 2009-09-02 | @ CHN | 133 | L 0-2 | - | | 39,192 | Felipe Paulino | Ted Lilly | Ted Lilly | Felipe Paulino | Carlos Marmol | 544 | 635 | -91 |
| 2009-09-04 | vs PHI | 134 | W 7-0 | - | | 30,043 | Wandy Rodriguez | Cliff Lee | Wandy Rodriguez | Cliff Lee | | 551 | 635 | -84 |
| 2009-09-05 | vs PHI | 135 | W 5-4 | - | | 35,195 | Roy Oswalt | Joe Blanton | Jose Valverde | Brad Lidge | | 556 | 639 | -83 |
| 2009-09-06 | vs PHI | 136 | W 4-3 | - | | 34,754 | Bud Norris | Cole Hamels | Bud Norris | Cole Hamels | Jose Valverde | 560 | 642 | -82 |
| 2009-09-07 | vs PHI | 137 | W 4-3 | - | | 29,040 | Brian Moehler | Jamie Moyer | Wesley Wright | Chan Ho Park | Jose Valverde | 564 | 645 | -81 |
| 2009-09-08 | vs ATL | 138 | L 1-2 | - | | 26,081 | Felipe Paulino | Javier Vazquez | Javier Vazquez | Felipe Paulino | Rafael Soriano | 565 | 647 | -82 |
| 2009-09-09 | vs ATL | 139 | W 2-1 | - | | 22,392 | Wandy Rodriguez | Tommy Hanson | Jose Valverde | Rafael Soriano | | 567 | 648 | -81 |
| 2009-09-10 | vs ATL | 140 | L 7-9 | - | | 26,552 | Roy Oswalt | Derek Lowe | Derek Lowe | Roy Oswalt | Mike Gonzalez | 574 | 657 | -83 |
| 2009-09-11 | vs PIT | 141 | W 9-1 | - | | 31,302 | Bud Norris | Charlie Morton | Bud Norris | Charlie Morton | | 583 | 658 | -75 |
| 2009-09-12 | vs PIT | 142 | W 4-2 | - | | 35,213 | Brian Moehler | Ross Ohlendorf | Jeff Fulchino | Ross Ohlendorf | Jose Valverde | 587 | 660 | -73 |
| 2009-09-13 | vs PIT | 143 | L 1-2 | - | | 34,405 | Felipe Paulino | Paul Maholm | Paul Maholm | Felipe Paulino | Matt Capps | 588 | 662 | -74 |
| 2009-09-14 | @ CIN | 144 | L 1-3 | - | | 9,852 | Wandy Rodriguez | Bronson Arroyo | Bronson Arroyo | Wandy Rodriguez | Francisco Cordero | 589 | 665 | -76 |
| 2009-09-15 | @ CIN | 145 | L 4-5 | - | | 11,923 | Roy Oswalt | Kip Wells | Danny Herrera | Samuel Gervacio | Francisco Cordero | 593 | 670 | -77 |
| 2009-09-16 | @ CIN | 146 | L 5-6 | - | | 10,662 | Yorman Bazardo | Justin Lehr | Jared Burton | Wesley Wright | Francisco Cordero | 598 | 676 | -78 |
| 2009-09-18 | @ MIL | 147 | L 2-3 | - | | 39,057 | Bud Norris | Chris Narveson | David Weathers | Wesley Wright | Trevor Hoffman | 600 | 679 | -79 |
| 2009-09-19 | @ MIL | 148 | L 2-7 | - | | 36,399 | Brian Moehler | Jeff Suppan | Jeff Suppan | Tim Byrdak | | 602 | 686 | -84 |
| 2009-09-20 | @ MIL | 149 | L 0-6 | - | | 30,024 | Felipe Paulino | Yovani Gallardo | Yovani Gallardo | Felipe Paulino | | 602 | 692 | -90 |
| 2009-09-21 | vs SLN | 150 | L 3-7 | - | | 34,705 | Wandy Rodriguez | Kyle Lohse | Kyle Lohse | Wandy Rodriguez | | 605 | 699 | -94 |
| 2009-09-22 | vs SLN | 151 | L 2-11 | - | | 32,644 | Yorman Bazardo | Joel Pineiro | Joel Pineiro | Yorman Bazardo | | 607 | 710 | -103 |
| 2009-09-23 | vs SLN | 152 | W 3-0 | - | | 38,732 | Bud Norris | John Smoltz | Bud Norris | John Smoltz | Jose Valverde | 610 | 710 | -100 |
| 2009-09-25 | vs CIN | 153 | L 4-10 | - | | 37,710 | Brian Moehler | Matt Maloney | Matt Maloney | Brian Moehler | | 614 | 720 | -106 |
| 2009-09-26 | vs CIN | 154 | L 4-10 | - | | 39,476 | Felipe Paulino | Justin Lehr | Justin Lehr | Felipe Paulino | | 618 | 730 | -112 |
| 2009-09-27 | vs CIN | 155 | W 3-2 | - | | 37,595 | Wandy Rodriguez | Johnny Cueto | Wandy Rodriguez | Johnny Cueto | Jose Valverde | 621 | 732 | -111 |
| 2009-09-28 | @ PHI | 156 | W 8-2 | - | | 45,146 | Yorman Bazardo | Cole Hamels | Yorman Bazardo | Cole Hamels | | 629 | 734 | -105 |
| 2009-09-29 | @ PHI | 157 | L 4-7 | - | | 45,082 | Wilton Lopez | J.A. Happ | J.A. Happ | Wilton Lopez | Ryan Madson | 633 | 741 | -108 |
| 2009-09-30 | @ PHI | 158 | L 3-10 | - | | 45,207 | Brian Moehler | Pedro Martinez | Kyle Kendrick | Brian Moehler | | 636 | 751 | -115 |
| 2009-10-01 | @ PHI | 159 | W 5-3 | - | | 44,905 | Felipe Paulino | Cliff Lee | Felipe Paulino | Cliff Lee | | 641 | 754 | -113 |
| 2009-10-02 | @ NYN | 160 | L 1-7 | - | | 37,576 | Wandy Rodriguez | John Maine | John Maine | Wandy Rodriguez | | 642 | 761 | -119 |
| 2009-10-03 | @ NYN | 161 | L 1-5 | - | | 37,578 | Yorman Bazardo | Pat Misch | Pat Misch | Yorman Bazardo | Francisco Rodriguez | 643 | 766 | -123 |
| 2009-10-04 | @ NYN | 162 | L 0-4 | - | | 38,135 | Wilton Lopez | Nelson Figueroa | Nelson Figueroa | Wilton Lopez | | 643 | 770 | -127 |