| 2009-04-06 | vs WAS | 1 | W 12-6 | 0-1 | 4 | 34,323 | Ricky Nolasco | John Lannan | Ricky Nolasco | John Lannan | | 12 | 6 | 6 |
| 2009-04-07 | vs WAS | 2 | W 8-3 | 1-1 | 3 | 11,124 | Josh Johnson | Scott Olsen | Josh Johnson | Scott Olsen | | 20 | 9 | 11 |
| 2009-04-08 | vs WAS | 3 | W 6-4 | 2-1 | 3 | 13,308 | Chris Volstad | Daniel Cabrera | Chris Volstad | Daniel Cabrera | Matt Lindstrom | 26 | 13 | 13 |
| 2009-04-10 | vs NYN | 4 | W 5-4 | 3-1 | 2 | 24,070 | Anibal Sanchez | John Maine | Matt Lindstrom | Pedro Feliciano | | 31 | 17 | 14 |
| 2009-04-11 | vs NYN | 5 | L 4-8 | 3-2 | 2 | 39,412 | Ricky Nolasco | Livan Hernandez | Livan Hernandez | Ricky Nolasco | | 35 | 25 | 10 |
| 2009-04-12 | vs NYN | 6 | W 2-1 | 4-2 | 2 | 18,109 | Josh Johnson | Johan Santana | Josh Johnson | Johan Santana | | 37 | 26 | 11 |
| 2009-04-14 | @ ATL | 7 | W 5-1 | 5-2 | 2 | 16,293 | Chris Volstad | Javier Vazquez | Chris Volstad | Javier Vazquez | | 42 | 27 | 15 |
| 2009-04-15 | @ ATL | 8 | W 10-4 | 5-3 | 3 | 19,204 | Andrew Miller | Derek Lowe | Hayden Penn | Peter Moylan | | 52 | 31 | 21 |
| 2009-04-16 | @ ATL | 9 | W 6-2 | 6-3 | 2 | 21,072 | Anibal Sanchez | Kenshin Kawakami | Anibal Sanchez | Kenshin Kawakami | | 58 | 33 | 25 |
| 2009-04-17 | @ WAS | 10 | W 3-2 | 7-3 | 1 | 19,026 | Ricky Nolasco | John Lannan | Leo Nunez | Saul Rivera | Matt Lindstrom | 61 | 35 | 26 |
| 2009-04-18 | @ WAS | 11 | W 9-6 | 8-3 | 1 | 19,864 | Josh Johnson | Scott Olsen | Kiko Calero | Julian Tavarez | | 70 | 41 | 29 |
| 2009-04-19 | @ WAS | 12 | W 7-4 | 9-3 | 1 | 16,974 | Chris Volstad | Daniel Cabrera | Leo Nunez | Saul Rivera | Matt Lindstrom | 77 | 45 | 32 |
| 2009-04-20 | @ PIT | 13 | L 0-8 | 9-4 | 1 | 8,790 | Andrew Miller | Ross Ohlendorf | Ross Ohlendorf | Andrew Miller | | 77 | 53 | 24 |
| 2009-04-21 | @ PIT | 14 | L 2-3 | 9-5 | 1 | 9,917 | Anibal Sanchez | Jeff Karstens | Jeff Karstens | Anibal Sanchez | Matt Capps | 79 | 56 | 23 |
| 2009-04-22 | @ PIT | 15 | L 4-7 | 9-6 | 1 | 10,655 | Ricky Nolasco | Paul Maholm | Paul Maholm | Ricky Nolasco | Matt Capps | 83 | 63 | 20 |
| 2009-04-24 | vs PHI | 16 | L 3-7 | 9-7 | 2 | 29,032 | Josh Johnson | Brett Myers | Clay Condrey | Matt Lindstrom | | 86 | 70 | 16 |
| 2009-04-25 | vs PHI | 17 | L 4-6 | 9-8 | 2 | 26,412 | Chris Volstad | Chan Ho Park | Ryan Madson | Logan Kensing | Brad Lidge | 90 | 76 | 14 |
| 2009-04-26 | vs PHI | 18 | L 2-13 | 10-8 | 1 | 17,177 | Graham Taylor | Jamie Moyer | Jamie Moyer | Graham Taylor | | 92 | 89 | 3 |
| 2009-04-27 | @ NYN | 19 | L 1-7 | 10-9 | 1 | 38,573 | Anibal Sanchez | John Maine | John Maine | Anibal Sanchez | | 93 | 96 | -3 |
| 2009-04-28 | @ NYN | 20 | W 7-4 | 11-9 | 1 | 38,546 | Ricky Nolasco | Livan Hernandez | Burke Badenhop | Sean Green | Matt Lindstrom | 100 | 100 | 0 |
| 2009-04-29 | @ NYN | 21 | W 4-3 | 12-9 | 1 | 39,339 | Josh Johnson | Johan Santana | Renyel Pinto | J.J. Putz | Matt Lindstrom | 104 | 103 | 1 |
| 2009-04-30 | @ CHN | 22 | W 8-2 | 13-9 | 1 | 37,956 | Chris Volstad | Sean Marshall | Renyel Pinto | Aaron Heilman | | 112 | 105 | 7 |
| 2009-05-01 | @ CHN | 23 | L 6-8 | 13-10 | 1 | 38,336 | Graham Taylor | Rich Harden | David Patton | Burke Badenhop | Kevin Gregg | 118 | 113 | 5 |
| 2009-05-02 | @ CHN | 24 | L 1-6 | 13-11 | 1 | 40,083 | Anibal Sanchez | Ted Lilly | Ted Lilly | Anibal Sanchez | | 119 | 119 | 0 |
| 2009-05-03 | @ CHN | 25 | L 4-6 | 13-12 | 1 | 40,457 | Ricky Nolasco | Carlos Zambrano | Carlos Zambrano | Ricky Nolasco | Kevin Gregg | 123 | 125 | -2 |
| 2009-05-04 | vs CIN | 26 | W 3-2 | 14-12 | 1 | 10,825 | Josh Johnson | Aaron Harang | Burke Badenhop | Danny Herrera | | 126 | 127 | -1 |
| 2009-05-05 | vs CIN | 27 | L 0-7 | 14-13 | 2 | 11,087 | Chris Volstad | Edinson Volquez | Edinson Volquez | Chris Volstad | | 126 | 134 | -8 |
| 2009-05-06 | vs ATL | 28 | L 6-8 | 14-14 | 2 | 12,725 | Graham Taylor | Derek Lowe | Derek Lowe | Graham Taylor | Mike Gonzalez | 132 | 142 | -10 |
| 2009-05-07 | vs ATL | 29 | L 2-4 | 14-15 | 2 | 17,759 | Anibal Sanchez | Jair Jurrjens | Jair Jurrjens | Anibal Sanchez | Mike Gonzalez | 134 | 146 | -12 |
| 2009-05-08 | @ COL | 30 | W 8-3 | 15-15 | 2 | 27,398 | Ricky Nolasco | Jason Hammel | Ricky Nolasco | Jason Hammel | | 142 | 149 | -7 |
| 2009-05-09 | @ COL | 31 | W 3-1 | 16-15 | 2 | 28,227 | Josh Johnson | Jorge de la Rosa | Josh Johnson | Jorge de la Rosa | Matt Lindstrom | 145 | 150 | -5 |
| 2009-05-10 | @ COL | 32 | L 2-3 | 16-16 | 3 | 30,197 | Chris Volstad | Aaron Cook | Aaron Cook | Chris Volstad | Huston Street | 147 | 153 | -6 |
| 2009-05-12 | @ MIL | 33 | L 3-6 | 16-17 | 3 | 29,331 | John Koronka | Manny Parra | Manny Parra | John Koronka | Trevor Hoffman | 150 | 159 | -9 |
| 2009-05-13 | @ MIL | 34 | L 6-8 | 16-18 | 3 | 32,825 | Ricky Nolasco | Braden Looper | Braden Looper | Ricky Nolasco | Trevor Hoffman | 156 | 167 | -11 |
| 2009-05-14 | @ MIL | 35 | L 3-5 | 16-19 | 3 | 35,658 | Josh Johnson | David Bush | David Bush | Burke Badenhop | Trevor Hoffman | 159 | 172 | -13 |
| 2009-05-15 | vs LAN | 36 | L 4-6 | 16-20 | 4 | 20,039 | Chris Volstad | Eric Stults | Jeff Weaver | Chris Volstad | Jonathan Broxton | 163 | 178 | -15 |
| 2009-05-16 | vs LAN | 37 | W 6-3 | 17-20 | 3 | 25,132 | Andrew Miller | Eric Milton | Andrew Miller | Jeff Weaver | Matt Lindstrom | 169 | 181 | -12 |
| 2009-05-17 | vs LAN | 38 | L 5-12 | 18-20 | 3 | 16,332 | John Koronka | Clayton Kershaw | Clayton Kershaw | John Koronka | | 174 | 193 | -19 |
| 2009-05-19 | vs ARI | 39 | L 3-5 | 18-21 | 3 | 10,131 | Josh Johnson | Jon Garland | Jon Garland | Josh Johnson | Chad Qualls | 177 | 198 | -21 |
| 2009-05-20 | vs ARI | 40 | W 8-6 | 19-21 | 4 | 0 | Chris Volstad | Doug Davis | Chris Volstad | Doug Davis | Matt Lindstrom | 185 | 204 | -19 |
| 2009-05-20 | vs ARI | 41 | L 9-11 | 19-21 | 4 | 14,426 | Hayden Penn | Bryan Augenstein | Chad Qualls | Leo Nunez | Jon Rauch | 194 | 215 | -21 |
| 2009-05-21 | vs ARI | 42 | L 3-4 | 20-22 | 3 | 12,045 | Andrew Miller | Max Scherzer | Clay Zavada | Cristhian Martinez | Chad Qualls | 197 | 219 | -22 |
| 2009-05-22 | vs TBA | 43 | L 2-15 | 21-22 | 3 | 16,226 | Ricky Nolasco | Andy Sonnanstine | Andy Sonnanstine | Ricky Nolasco | Dale Thayer | 199 | 234 | -35 |
| 2009-05-23 | vs TBA | 44 | L 3-10 | 22-22 | 3 | 20,253 | Sean West | Jeff Niemann | Grant Balfour | Leo Nunez | | 202 | 244 | -42 |
| 2009-05-24 | vs TBA | 45 | W 5-4 | 23-22 | 3 | 12,839 | Josh Johnson | James Shields | Brian Sanches | Lance Cormier | | 207 | 248 | -41 |
| 2009-05-25 | @ PHI | 46 | W 5-3 | 24-22 | 2 | 45,186 | Chris Volstad | Jamie Moyer | Chris Volstad | Jamie Moyer | Matt Lindstrom | 212 | 251 | -39 |
| 2009-05-26 | @ PHI | 47 | L 3-5 | 24-23 | 2 | 42,249 | Andrew Miller | Joe Blanton | Joe Blanton | Andrew Miller | Brad Lidge | 215 | 256 | -41 |
| 2009-05-27 | @ PHI | 48 | W 6-2 | 25-23 | 2 | 45,256 | Burke Badenhop | Brett Myers | Burke Badenhop | Brett Myers | | 221 | 258 | -37 |
| 2009-05-29 | @ NYN | 49 | L 1-2 | 25-24 | 2 | 40,677 | Sean West | Mike Pelfrey | Pedro Feliciano | Brian Sanches | | 222 | 260 | -38 |
| 2009-05-30 | @ NYN | 50 | W 7-3 | 26-24 | 2 | 40,727 | Josh Johnson | Tim Redding | Josh Johnson | Tim Redding | Leo Nunez | 229 | 263 | -34 |
| 2009-05-31 | @ NYN | 51 | L 2-3 | 26-25 | 2 | 40,482 | Chris Volstad | John Maine | John Maine | Chris Volstad | Francisco Rodriguez | 231 | 266 | -35 |
| 2009-06-01 | vs MIL | 52 | W 7-4 | 27-25 | 2 | 10,509 | Andrew Miller | Jeff Suppan | Cristhian Martinez | Jorge Julio | Matt Lindstrom | 238 | 270 | -32 |
| 2009-06-02 | vs MIL | 53 | W 10-3 | 27-26 | 2 | 10,831 | Anibal Sanchez | Manny Parra | Burke Badenhop | Manny Parra | | 248 | 273 | -25 |
| 2009-06-03 | vs MIL | 54 | L 6-9 | 27-27 | 2 | 13,012 | Sean West | Braden Looper | Seth McClung | Sean West | Trevor Hoffman | 254 | 282 | -28 |
| 2009-06-04 | vs MIL | 55 | W 4-3 | 28-27 | 2 | 11,623 | Josh Johnson | David Bush | Josh Johnson | David Bush | Matt Lindstrom | 258 | 285 | -27 |
| 2009-06-05 | vs SFN | 56 | L 1-2 | 28-28 | 2 | 12,841 | Chris Volstad | Barry Zito | Barry Zito | Chris Volstad | Brian Wilson | 259 | 287 | -28 |
| 2009-06-06 | vs SFN | 57 | W 5-4 | 29-28 | 2 | 16,294 | Andrew Miller | Jonathan Sanchez | Andrew Miller | Jonathan Sanchez | Leo Nunez | 264 | 291 | -27 |
| 2009-06-07 | vs SFN | 58 | L 2-3 | 29-29 | 2 | 11,505 | Ricky Nolasco | Tim Lincecum | Tim Lincecum | Ricky Nolasco | Brian Wilson | 266 | 294 | -28 |
| 2009-06-08 | vs SFN | 59 | W 4-0 | 30-29 | 2 | 12,068 | Sean West | Randy Johnson | Sean West | Randy Johnson | | 270 | 294 | -24 |
| 2009-06-09 | vs SLN | 60 | W 4-3 | 31-29 | 2 | 13,103 | Josh Johnson | Chris Carpenter | Matt Lindstrom | Jason Motte | | 274 | 297 | -23 |
| 2009-06-10 | vs SLN | 61 | L 4-13 | 32-29 | 2 | 14,624 | Chris Volstad | Adam Wainwright | Adam Wainwright | Chris Volstad | | 278 | 310 | -32 |
| 2009-06-11 | vs SLN | 62 | L 5-6 | 32-30 | 2 | 19,112 | Andrew Miller | Todd Wellemeyer | Trever Miller | Leo Nunez | Ryan Franklin | 283 | 316 | -33 |
| 2009-06-12 | @ TOR | 63 | W 7-3 | 33-30 | 2 | 17,922 | Ricky Nolasco | Roy Halladay | Dan Meyer | Brandon League | | 290 | 319 | -29 |
| 2009-06-13 | @ TOR | 64 | W 6-5 | 34-30 | 2 | 20,634 | Sean West | Casey Janssen | Sean West | Casey Janssen | Matt Lindstrom | 296 | 324 | -28 |
| 2009-06-14 | @ TOR | 65 | W 11-3 | 34-31 | 2 | 20,985 | Josh Johnson | Brian Tallet | Josh Johnson | Brian Tallet | | 307 | 327 | -20 |
| 2009-06-16 | @ BOS | 66 | L 2-8 | 34-32 | 2 | 38,149 | Chris Volstad | Tim Wakefield | Tim Wakefield | Chris Volstad | | 309 | 335 | -26 |
| 2009-06-17 | @ BOS | 67 | L 1-6 | 34-33 | 2 | 38,196 | Andrew Miller | Brad Penny | Brad Penny | Andrew Miller | | 310 | 341 | -31 |
| 2009-06-18 | @ BOS | 68 | W 2-1 | 35-33 | 2 | 37,577 | Ricky Nolasco | Jon Lester | Ricky Nolasco | Jon Lester | | 312 | 342 | -30 |
| 2009-06-19 | vs NYA | 69 | L 1-5 | 35-34 | 2 | 35,027 | Sean West | Andy Pettitte | Andy Pettitte | Sean West | | 313 | 347 | -34 |
| 2009-06-20 | vs NYA | 70 | W 2-1 | 36-34 | 2 | 46,427 | Josh Johnson | A.J. Burnett | Josh Johnson | A.J. Burnett | Matt Lindstrom | 315 | 348 | -33 |
| 2009-06-21 | vs NYA | 71 | W 6-5 | 37-34 | 2 | 35,827 | Chris Volstad | CC Sabathia | Chris Volstad | Brett Tomko | Matt Lindstrom | 321 | 353 | -32 |
| 2009-06-23 | vs BAL | 72 | W 7-6 | 38-34 | 2 | 10,222 | Andrew Miller | Koji Uehara | Burke Badenhop | Brian Bass | | 328 | 359 | -31 |
| 2009-06-24 | vs BAL | 73 | W 5-2 | 39-34 | 2 | 12,469 | Ricky Nolasco | Jason Berken | Ricky Nolasco | Jason Berken | Dan Meyer | 333 | 361 | -28 |
| 2009-06-25 | vs BAL | 74 | W 11-3 | 39-35 | 2 | 12,822 | Sean West | Rich Hill | Sean West | Rich Hill | | 344 | 364 | -20 |
| 2009-06-26 | @ TBA | 75 | L 3-7 | 39-36 | 2 | 20,972 | Josh Johnson | James Shields | J.P. Howell | Renyel Pinto | | 347 | 371 | -24 |
| 2009-06-27 | @ TBA | 76 | L 2-3 | 39-37 | 2 | 35,790 | Chris Volstad | Scott Kazmir | J.P. Howell | Burke Badenhop | | 349 | 374 | -25 |
| 2009-06-28 | @ TBA | 77 | L 2-5 | 39-38 | 2 | 29,459 | Andrew Miller | David Price | David Price | Andrew Miller | J.P. Howell | 351 | 379 | -28 |
| 2009-06-29 | vs WAS | 78 | W 4-2 | 40-38 | 2 | 10,623 | Ricky Nolasco | Scott Olsen | Ricky Nolasco | Ron Villone | Leo Nunez | 355 | 381 | -26 |
| 2009-06-30 | vs WAS | 79 | W 7-5 | 41-38 | 2 | 11,821 | Sean West | Craig Stammen | Renyel Pinto | Joe Beimel | | 362 | 386 | -24 |
| 2009-07-01 | vs WAS | 80 | W 5-3 | 42-38 | 2 | 27,032 | Josh Johnson | Jordan Zimmermann | Dan Meyer | Julian Tavarez | Leo Nunez | 367 | 389 | -22 |
| 2009-07-03 | vs PIT | 81 | L 4-7 | 42-39 | 2 | 16,114 | Chris Volstad | Charlie Morton | Charlie Morton | Chris Volstad | | 371 | 396 | -25 |
| 2009-07-04 | vs PIT | 82 | W 5-3 | 43-39 | 2 | 25,303 | Andrew Miller | Zach Duke | Andrew Miller | Zach Duke | Dan Meyer | 376 | 399 | -23 |
| 2009-07-05 | vs PIT | 83 | W 5-0 | 44-39 | 2 | 13,287 | Ricky Nolasco | Ross Ohlendorf | Ricky Nolasco | Ross Ohlendorf | | 381 | 399 | -18 |
| 2009-07-06 | @ SFN | 84 | L 4-5 | 44-40 | 2 | 26,995 | Sean West | Matt Cain | Matt Cain | Sean West | Brian Wilson | 385 | 404 | -19 |
| 2009-07-07 | @ SFN | 85 | L 0-3 | 44-41 | 2 | 27,799 | Josh Johnson | Barry Zito | Barry Zito | Josh Johnson | Sergio Romo | 385 | 407 | -22 |
| 2009-07-08 | @ SFN | 86 | W 7-0 | 45-41 | 2 | 34,157 | Chris Volstad | Ryan Sadowski | Chris Volstad | Ryan Sadowski | | 392 | 407 | -15 |
| 2009-07-09 | @ ARI | 87 | W 14-7 | 45-42 | 2 | 21,558 | Andrew Miller | Yusmeiro Petit | Kiko Calero | Scott Schoeneweis | | 406 | 414 | -8 |
| 2009-07-10 | @ ARI | 88 | L 0-8 | 45-43 | 2 | 21,307 | Ricky Nolasco | Dan Haren | Dan Haren | Ricky Nolasco | | 406 | 422 | -16 |
| 2009-07-11 | @ ARI | 89 | L 1-5 | 45-44 | 2 | 29,477 | Sean West | Jon Garland | Jon Garland | Sean West | | 407 | 427 | -20 |
| 2009-07-12 | @ ARI | 90 | W 8-1 | 46-44 | 2 | 28,617 | Josh Johnson | Doug Davis | Josh Johnson | Doug Davis | | 415 | 428 | -13 |
| 2009-07-16 | vs PHI | 91 | L 0-4 | 46-45 | 3 | 15,171 | Chris Volstad | Jamie Moyer | Jamie Moyer | Chris Volstad | | 415 | 432 | -17 |
| 2009-07-17 | vs PHI | 92 | L 5-6 | 46-46 | 4 | 22,891 | Ricky Nolasco | Cole Hamels | Clay Condrey | Burke Badenhop | Brad Lidge | 420 | 438 | -18 |
| 2009-07-19 | vs PHI | 93 | L 0-5 | 46-47 | 4 | 15,033 | Andrew Miller | J.A. Happ | J.A. Happ | Andrew Miller | | 420 | 443 | -23 |
| 2009-07-20 | @ SDN | 94 | W 3-2 | 47-47 | 3 | 17,184 | Rick Vanden Hurk | Tim Stauffer | Rick Vanden Hurk | Greg Burke | Leo Nunez | 423 | 445 | -22 |
| 2009-07-21 | @ SDN | 95 | W 3-2 | 48-47 | 3 | 20,311 | Chris Volstad | Chad Gaudin | Chris Volstad | Chad Gaudin | Leo Nunez | 426 | 447 | -21 |
| 2009-07-22 | @ SDN | 96 | W 5-0 | 49-47 | 3 | 16,450 | Ricky Nolasco | Josh Geer | Ricky Nolasco | Josh Geer | | 431 | 447 | -16 |
| 2009-07-24 | @ LAN | 97 | W 6-3 | 50-47 | 3 | 51,565 | Josh Johnson | Clayton Kershaw | Josh Johnson | James McDonald | Leo Nunez | 437 | 450 | -13 |
| 2009-07-25 | @ LAN | 98 | L 3-4 | 50-48 | 3 | 50,248 | Rick Vanden Hurk | Hiroki Kuroda | Jonathan Broxton | Dan Meyer | | 440 | 454 | -14 |
| 2009-07-26 | @ LAN | 99 | W 8-6 | 51-48 | 3 | 48,597 | Chris Volstad | Jason Schmidt | Chris Volstad | Jason Schmidt | | 448 | 460 | -12 |
| 2009-07-28 | vs ATL | 100 | W 4-3 | 52-48 | 3 | 13,128 | Ricky Nolasco | Jair Jurrjens | Leo Nunez | Rafael Soriano | | 452 | 463 | -11 |
| 2009-07-29 | vs ATL | 101 | W 6-3 | 53-48 | 3 | 13,518 | Josh Johnson | Kenshin Kawakami | Josh Johnson | Kenshin Kawakami | Leo Nunez | 458 | 466 | -8 |
| 2009-07-30 | vs ATL | 102 | L 3-6 | 53-49 | 4 | 14,226 | Rick Vanden Hurk | Javier Vazquez | Peter Moylan | Luis Ayala | Rafael Soriano | 461 | 472 | -11 |
| 2009-07-31 | vs CHN | 103 | W 5-2 | 54-49 | 3 | 25,024 | Chris Volstad | Rich Harden | Brendan Donnelly | Carlos Marmol | Leo Nunez | 466 | 474 | -8 |
| 2009-08-01 | vs CHN | 104 | L 8-9 | 54-50 | 3 | 35,811 | Burke Badenhop | Carlos Zambrano | Kevin Gregg | Leo Nunez | Aaron Heilman | 474 | 483 | -9 |
| 2009-08-02 | vs CHN | 105 | W 3-2 | 55-50 | 3 | 25,969 | Ricky Nolasco | Ryan Dempster | Brendan Donnelly | Kevin Gregg | | 477 | 485 | -8 |
| 2009-08-04 | @ WAS | 106 | L 4-6 | 55-51 | 3 | 19,828 | Josh Johnson | J.D. Martin | Ron Villone | Kiko Calero | Mike MacDougal | 481 | 491 | -10 |
| 2009-08-05 | @ WAS | 107 | L 4-5 | 55-52 | 3 | 18,312 | Rick Vanden Hurk | John Lannan | John Lannan | Rick Vanden Hurk | Mike MacDougal | 485 | 496 | -11 |
| 2009-08-06 | @ WAS | 108 | L 8-12 | 56-52 | 3 | 23,691 | Chris Volstad | Craig Stammen | Jorge Sosa | Luis Ayala | | 493 | 508 | -15 |
| 2009-08-07 | @ PHI | 109 | W 3-2 | 57-52 | 2 | 45,114 | Ricky Nolasco | Joe Blanton | Ricky Nolasco | Joe Blanton | Leo Nunez | 496 | 510 | -14 |
| 2009-08-08 | @ PHI | 110 | W 6-4 | 58-52 | 1 | 45,086 | Sean West | Cole Hamels | Brian Sanches | Cole Hamels | Leo Nunez | 502 | 514 | -12 |
| 2009-08-09 | @ PHI | 111 | W 12-3 | 58-53 | 2 | 45,169 | Josh Johnson | Jamie Moyer | Josh Johnson | Jamie Moyer | | 514 | 517 | -3 |
| 2009-08-10 | vs HOU | 112 | W 8-6 | 59-53 | 1 | 12,325 | Rick Vanden Hurk | Brian Moehler | Rick Vanden Hurk | Brian Moehler | Leo Nunez | 522 | 523 | -1 |
| 2009-08-11 | vs HOU | 113 | W 9-8 | 60-53 | 1 | 13,312 | Chris Volstad | Roy Oswalt | Brian Sanches | Wesley Wright | | 531 | 531 | 0 |
| 2009-08-12 | vs HOU | 114 | L 6-14 | 61-53 | 1 | 21,122 | Ricky Nolasco | Bud Norris | Bud Norris | Ricky Nolasco | | 537 | 545 | -8 |
| 2009-08-13 | vs HOU | 115 | W 9-2 | 62-53 | 1 | 14,047 | Sean West | Mike Hampton | Sean West | Mike Hampton | | 546 | 547 | -1 |
| 2009-08-14 | vs COL | 116 | W 6-5 | 63-53 | 1 | 15,965 | Josh Johnson | Jason Hammel | Josh Johnson | Jason Hammel | Leo Nunez | 552 | 552 | 0 |
| 2009-08-16 | vs COL | 117 | W 10-3 | 63-55 | 2 | 0 | Chris Volstad | Aaron Cook | Chris Volstad | Aaron Cook | | 562 | 555 | 7 |
| 2009-08-16 | vs COL | 118 | L 3-7 | 63-55 | 2 | 20,089 | Rick Vanden Hurk | Jorge de la Rosa | Jorge de la Rosa | Rick Vanden Hurk | Huston Street | 565 | 562 | 3 |
| 2009-08-18 | @ HOU | 119 | W 6-2 | 64-55 | 1 | 30,189 | Ricky Nolasco | Bud Norris | Ricky Nolasco | Bud Norris | | 571 | 564 | 7 |
| 2009-08-19 | @ HOU | 120 | L 3-6 | 64-56 | 2 | 30,101 | Sean West | Yorman Bazardo | Samuel Gervacio | Sean West | Jose Valverde | 574 | 570 | 4 |
| 2009-08-20 | @ HOU | 121 | L 1-4 | 64-57 | 2 | 30,039 | Josh Johnson | Wandy Rodriguez | Wandy Rodriguez | Josh Johnson | Jose Valverde | 575 | 574 | 1 |
| 2009-08-21 | @ ATL | 122 | W 5-3 | 65-57 | 1 | 22,608 | Anibal Sanchez | Javier Vazquez | Anibal Sanchez | Javier Vazquez | Leo Nunez | 580 | 577 | 3 |
| 2009-08-22 | @ ATL | 123 | L 3-4 | 65-58 | 2 | 35,200 | Chris Volstad | Tommy Hanson | Tommy Hanson | Chris Volstad | Rafael Soriano | 583 | 581 | 2 |
| 2009-08-23 | @ ATL | 124 | L 5-7 | 65-59 | 2 | 30,478 | Ricky Nolasco | Derek Lowe | Peter Moylan | Kiko Calero | Rafael Soriano | 588 | 588 | 0 |
| 2009-08-25 | vs NYN | 125 | W 2-1 | 66-59 | 2 | 14,278 | Sean West | Nelson Figueroa | Sean West | Nelson Figueroa | Leo Nunez | 590 | 589 | 1 |
| 2009-08-26 | vs NYN | 126 | W 5-3 | 67-59 | 2 | 16,123 | Josh Johnson | Mike Pelfrey | Josh Johnson | Mike Pelfrey | Leo Nunez | 595 | 592 | 3 |
| 2009-08-27 | vs NYN | 127 | L 3-10 | 68-59 | 2 | 12,423 | Anibal Sanchez | Tim Redding | Tim Redding | Anibal Sanchez | | 598 | 602 | -4 |
| 2009-08-28 | vs SDN | 128 | L 5-9 | 68-60 | 2 | 14,402 | Chris Volstad | Kevin Correia | Kevin Correia | Chris Volstad | | 603 | 611 | -8 |
| 2009-08-29 | vs SDN | 129 | L 4-7 | 68-61 | 2 | 20,924 | Ricky Nolasco | Wade LeBlanc | Adam Russell | Luis Ayala | Heath Bell | 607 | 618 | -11 |
| 2009-08-30 | vs SDN | 130 | W 6-4 | 69-61 | 2 | 12,873 | Sean West | Mat Latos | Sean West | Mat Latos | Leo Nunez | 613 | 622 | -9 |
| 2009-08-31 | vs ATL | 131 | L 2-5 | 69-62 | 2 | 12,244 | Josh Johnson | Kenshin Kawakami | Kenshin Kawakami | Josh Johnson | | 615 | 627 | -12 |
| 2009-09-01 | vs ATL | 132 | L 3-4 | 69-63 | 2 | 14,024 | Anibal Sanchez | Tim Hudson | Tim Hudson | Anibal Sanchez | Rafael Soriano | 618 | 631 | -13 |
| 2009-09-02 | vs ATL | 133 | W 8-7 | 70-63 | 2 | 14,723 | Rick Vanden Hurk | Javier Vazquez | Leo Nunez | Mike Gonzalez | | 626 | 638 | -12 |
| 2009-09-03 | vs ATL | 134 | W 8-3 | 71-63 | 2 | 13,711 | Ricky Nolasco | Tommy Hanson | Ricky Nolasco | Kris Medlen | | 634 | 641 | -7 |
| 2009-09-04 | @ WAS | 135 | W 9-6 | 72-63 | 2 | 16,364 | Sean West | Garrett Mock | Burke Badenhop | Garrett Mock | Leo Nunez | 643 | 647 | -4 |
| 2009-09-05 | @ WAS | 136 | W 9-5 | 73-63 | 1 | 18,111 | Josh Johnson | Livan Hernandez | Josh Johnson | Livan Hernandez | | 652 | 652 | 0 |
| 2009-09-06 | @ WAS | 137 | L 4-5 | 73-64 | 1 | 22,325 | Anibal Sanchez | J.D. Martin | Mike MacDougal | Leo Nunez | | 656 | 657 | -1 |
| 2009-09-08 | @ NYN | 138 | W 4-2 | 74-64 | 1 | 37,474 | Rick Vanden Hurk | Tim Redding | Brian Sanches | Tim Redding | Leo Nunez | 660 | 659 | 1 |
| 2009-09-09 | @ NYN | 139 | W 6-3 | 75-64 | 1 | 37,312 | Ricky Nolasco | Pat Misch | Ricky Nolasco | Pat Misch | Leo Nunez | 666 | 662 | 4 |
| 2009-09-10 | @ NYN | 140 | W 13-4 | 75-65 | 1 | 37,620 | Sean West | Bobby Parnell | Burke Badenhop | Bobby Parnell | | 679 | 666 | 13 |
| 2009-09-11 | vs WAS | 141 | L 3-5 | 75-66 | 2 | 15,247 | Josh Johnson | J.D. Martin | J.D. Martin | Brian Sanches | Mike MacDougal | 682 | 671 | 11 |
| 2009-09-12 | vs WAS | 142 | W 11-3 | 75-67 | 2 | 38,214 | Anibal Sanchez | Marco Estrada | Tim Wood | Marco Estrada | | 693 | 674 | 19 |
| 2009-09-13 | vs WAS | 143 | L 2-7 | 75-68 | 3 | 15,065 | Chris Volstad | John Lannan | John Lannan | Chris Volstad | | 695 | 681 | 14 |
| 2009-09-14 | @ SLN | 144 | L 6-11 | 76-68 | 2 | 43,582 | Ricky Nolasco | Todd Wellemeyer | Blake Hawksworth | Ricky Nolasco | | 701 | 692 | 9 |
| 2009-09-15 | @ SLN | 145 | W 2-1 | 77-68 | 2 | 42,895 | Sean West | Adam Wainwright | Sean West | Adam Wainwright | Leo Nunez | 703 | 693 | 10 |
| 2009-09-16 | @ SLN | 146 | W 5-2 | 78-68 | 2 | 43,020 | Josh Johnson | Joel Pineiro | Josh Johnson | Joel Pineiro | Leo Nunez | 708 | 695 | 13 |
| 2009-09-17 | @ CIN | 147 | L 2-3 | 78-69 | 2 | 9,685 | Anibal Sanchez | Matt Maloney | Matt Maloney | Anibal Sanchez | Francisco Cordero | 710 | 698 | 12 |
| 2009-09-18 | @ CIN | 148 | W 4-3 | 79-69 | 2 | 15,882 | Rick Vanden Hurk | Homer Bailey | Brendan Donnelly | Francisco Cordero | Leo Nunez | 714 | 701 | 13 |
| 2009-09-19 | @ CIN | 149 | W 3-2 | 80-69 | 2 | 17,026 | Ricky Nolasco | Bronson Arroyo | Ricky Nolasco | Bronson Arroyo | Matt Lindstrom | 717 | 703 | 14 |
| 2009-09-20 | @ CIN | 150 | L 1-8 | 80-70 | 2 | 16,186 | Sean West | Kip Wells | Kip Wells | Sean West | | 718 | 711 | 7 |
| 2009-09-22 | vs PHI | 151 | L 3-9 | 80-71 | 4 | 0 | Josh Johnson | Joe Blanton | Joe Blanton | Josh Johnson | | 721 | 720 | 1 |
| 2009-09-22 | vs PHI | 152 | W 3-0 | 80-71 | 4 | 20,039 | Anibal Sanchez | Jamie Moyer | Anibal Sanchez | Jamie Moyer | Leo Nunez | 724 | 720 | 4 |
| 2009-09-23 | vs PHI | 153 | W 7-6 | 82-71 | 2 | 31,042 | Rick Vanden Hurk | Cole Hamels | Dan Meyer | Brad Lidge | | 731 | 726 | 5 |
| 2009-09-25 | vs NYN | 154 | L 5-6 | 82-72 | 2 | 39,031 | Ricky Nolasco | Tim Redding | Bobby Parnell | Leo Nunez | Francisco Rodriguez | 736 | 732 | 4 |
| 2009-09-26 | vs NYN | 155 | W 9-6 | 83-72 | 2 | 35,666 | Sean West | John Maine | Sean West | John Maine | Brendan Donnelly | 745 | 738 | 7 |
| 2009-09-27 | vs NYN | 156 | L 0-4 | 83-73 | 2 | 31,167 | Chris Volstad | Pat Misch | Pat Misch | Chris Volstad | | 745 | 742 | 3 |
| 2009-09-28 | @ ATL | 157 | L 0-4 | 83-74 | 2 | 25,046 | Anibal Sanchez | Jair Jurrjens | Jair Jurrjens | Anibal Sanchez | | 745 | 746 | -1 |
| 2009-09-29 | @ ATL | 158 | W 5-4 | 84-74 | 2 | 28,669 | Josh Johnson | Tim Hudson | Renyel Pinto | Kenshin Kawakami | Leo Nunez | 750 | 750 | 0 |
| 2009-09-30 | @ ATL | 159 | W 5-4 | 85-74 | 2 | 31,513 | Ricky Nolasco | Javier Vazquez | Ricky Nolasco | Javier Vazquez | Brendan Donnelly | 755 | 754 | 1 |
| 2009-10-02 | @ PHI | 160 | W 7-2 | 86-74 | 1 | 45,135 | Rick Vanden Hurk | Joe Blanton | Rick Vanden Hurk | Joe Blanton | | 762 | 756 | 6 |
| 2009-10-03 | @ PHI | 161 | W 4-3 | 87-74 | 1 | 45,141 | Anibal Sanchez | Cole Hamels | Anibal Sanchez | Cole Hamels | Leo Nunez | 766 | 759 | 7 |
| 2009-10-04 | @ PHI | 162 | L 6-7 | 87-75 | 1 | 45,211 | Josh Johnson | J.A. Happ | Chad Durbin | Dan Meyer | | 772 | 766 | 6 |