| 2009-04-06 | @ TOR | 1 | L 5-12 | 1-0 | 1 | 48,027 | Justin Verlander | Roy Halladay | Roy Halladay | Justin Verlander | | 5 | 12 | -7 |
| 2009-04-07 | @ TOR | 2 | L 4-5 | 1-1 | 2 | 16,790 | Edwin Jackson | David Purcey | B.J. Ryan | Brandon Lyon | | 9 | 17 | -8 |
| 2009-04-08 | @ TOR | 3 | W 5-1 | 2-1 | 1 | 12,145 | Zach Miner | Jesse Litsch | Zach Miner | Jesse Litsch | | 14 | 18 | -4 |
| 2009-04-09 | @ TOR | 4 | L 2-6 | 2-2 | 2 | 15,297 | Rick Porcello | Ricky Romero | Ricky Romero | Rick Porcello | | 16 | 24 | -8 |
| 2009-04-10 | vs TEX | 5 | W 15-2 | 2-3 | 4 | 44,588 | Armando Galarraga | Kris Benson | Armando Galarraga | Kris Benson | | 31 | 26 | 5 |
| 2009-04-11 | vs TEX | 6 | W 4-3 | 3-3 | 2 | 28,693 | Justin Verlander | Matt Harrison | Nate Robertson | Matt Harrison | Fernando Rodney | 35 | 29 | 6 |
| 2009-04-12 | vs TEX | 7 | W 6-4 | 4-3 | 2 | 18,905 | Edwin Jackson | Kevin Millwood | Brandon Lyon | C.J. Wilson | Fernando Rodney | 41 | 33 | 8 |
| 2009-04-13 | vs CHA | 8 | L 6-10 | 5-3 | 1 | 21,850 | Zach Miner | Gavin Floyd | Gavin Floyd | Zach Miner | | 47 | 43 | 4 |
| 2009-04-15 | vs CHA | 9 | W 9-0 | 6-3 | 1 | 20,212 | Armando Galarraga | Jose Contreras | Armando Galarraga | Jose Contreras | | 56 | 43 | 13 |
| 2009-04-17 | @ SEA | 10 | L 3-6 | 6-4 | 1 | 35,824 | Justin Verlander | Felix Hernandez | Felix Hernandez | Justin Verlander | Brandon Morrow | 59 | 49 | 10 |
| 2009-04-18 | @ SEA | 11 | W 2-0 | 7-4 | 1 | 31,966 | Edwin Jackson | Erik Bedard | Edwin Jackson | Erik Bedard | Fernando Rodney | 61 | 49 | 12 |
| 2009-04-19 | @ SEA | 12 | W 8-2 | 8-4 | 1 | 30,450 | Rick Porcello | Carlos Silva | Rick Porcello | Carlos Silva | | 69 | 51 | 18 |
| 2009-04-21 | @ ANA | 13 | L 3-4 | 8-5 | 1 | 41,627 | Armando Galarraga | Jered Weaver | Jose Arredondo | Brandon Lyon | Brian Fuentes | 72 | 55 | 17 |
| 2009-04-22 | @ ANA | 14 | W 12-10 | 9-5 | 1 | 43,047 | Justin Verlander | Joe Saunders | Juan Rincon | Scot Shields | | 84 | 65 | 19 |
| 2009-04-23 | @ ANA | 15 | L 5-10 | 10-5 | 1 | 38,543 | Edwin Jackson | Matt Palmer | Matt Palmer | Edwin Jackson | | 89 | 75 | 14 |
| 2009-04-24 | @ KCA | 16 | L 1-6 | 10-6 | 1 | 36,363 | Rick Porcello | Zack Greinke | Zack Greinke | Rick Porcello | | 90 | 81 | 9 |
| 2009-04-25 | @ KCA | 17 | W 9-1 | 11-6 | 1 | 37,647 | Zach Miner | Kyle Davies | Zach Miner | Kyle Davies | | 99 | 82 | 17 |
| 2009-04-26 | @ KCA | 18 | W 3-2 | 12-6 | 1 | 13,520 | Armando Galarraga | Sidney Ponson | Armando Galarraga | Sidney Ponson | Fernando Rodney | 102 | 84 | 18 |
| 2009-04-27 | vs NYA | 19 | W 4-2 | 13-6 | 1 | 28,784 | Justin Verlander | CC Sabathia | Justin Verlander | CC Sabathia | | 106 | 86 | 20 |
| 2009-04-28 | vs NYA | 20 | L 0-11 | 13-7 | 1 | 25,519 | Edwin Jackson | Phil Hughes | Phil Hughes | Ryan Perry | | 106 | 97 | 9 |
| 2009-04-29 | vs NYA | 21 | L 6-8 | 13-8 | 1 | 28,348 | Rick Porcello | Joba Chamberlain | Joba Chamberlain | Rick Porcello | | 112 | 105 | 7 |
| 2009-05-01 | vs CLE | 22 | L 5-6 | 13-9 | 1 | 22,288 | Armando Galarraga | Carl Pavano | Carl Pavano | Armando Galarraga | Kerry Wood | 117 | 111 | 6 |
| 2009-05-02 | vs CLE | 23 | W 9-7 | 14-9 | 1 | 34,646 | Zach Miner | Aaron Laffey | Joel Zumaya | Rafael Betancourt | Fernando Rodney | 126 | 118 | 8 |
| 2009-05-03 | vs CLE | 24 | W 3-1 | 15-9 | 1 | 27,411 | Justin Verlander | Cliff Lee | Justin Verlander | Cliff Lee | Fernando Rodney | 129 | 119 | 10 |
| 2009-05-04 | vs MIN | 25 | L 2-7 | 15-10 | 1 | 21,298 | Edwin Jackson | Francisco Liriano | Francisco Liriano | Edwin Jackson | | 131 | 126 | 5 |
| 2009-05-05 | vs MIN | 26 | W 9-0 | 16-10 | 1 | 23,754 | Rick Porcello | Nick Blackburn | Rick Porcello | Nick Blackburn | | 140 | 126 | 14 |
| 2009-05-07 | @ CHA | 27 | L 0-6 | 16-11 | 1 | 27,475 | Armando Galarraga | Mark Buehrle | Mark Buehrle | Armando Galarraga | | 140 | 132 | 8 |
| 2009-05-08 | @ CLE | 28 | W 1-0 | 17-11 | 1 | 27,492 | Justin Verlander | Cliff Lee | Justin Verlander | Cliff Lee | | 141 | 132 | 9 |
| 2009-05-09 | @ CLE | 29 | W 4-0 | 18-11 | 1 | 33,640 | Edwin Jackson | Fausto Carmona | Edwin Jackson | Fausto Carmona | | 145 | 132 | 13 |
| 2009-05-10 | @ CLE | 30 | W 5-3 | 19-11 | 1 | 25,705 | Rick Porcello | Anthony Reyes | Rick Porcello | Anthony Reyes | | 150 | 135 | 15 |
| 2009-05-12 | @ MIN | 31 | L 2-6 | 19-12 | 1 | 24,807 | Armando Galarraga | Kevin Slowey | Kevin Slowey | Armando Galarraga | | 152 | 141 | 11 |
| 2009-05-13 | @ MIN | 32 | L 10-14 | 19-13 | 1 | 22,178 | Dontrelle Willis | Glen Perkins | Jesse Crain | Brandon Lyon | | 162 | 155 | 7 |
| 2009-05-14 | @ MIN | 33 | L 5-6 | 19-14 | 1 | 26,046 | Justin Verlander | Scott Baker | Craig Breslow | Bobby Seay | Joe Nathan | 167 | 161 | 6 |
| 2009-05-15 | vs OAK | 34 | W 14-1 | 20-14 | 1 | 26,770 | Edwin Jackson | Brett Anderson | Edwin Jackson | Brett Anderson | | 181 | 162 | 19 |
| 2009-05-16 | vs OAK | 35 | W 9-1 | 21-14 | 1 | 31,554 | Rick Porcello | Dallas Braden | Rick Porcello | Dallas Braden | | 190 | 163 | 27 |
| 2009-05-17 | vs OAK | 36 | W 11-7 | 21-15 | 1 | 27,535 | Armando Galarraga | Trevor Cahill | Zach Miner | Trevor Cahill | | 201 | 170 | 31 |
| 2009-05-19 | vs TEX | 37 | W 4-0 | 22-15 | 1 | 23,756 | Dontrelle Willis | Brandon McCarthy | Dontrelle Willis | Brandon McCarthy | | 205 | 170 | 35 |
| 2009-05-20 | vs TEX | 38 | W 5-3 | 23-15 | 1 | 23,417 | Justin Verlander | Matt Harrison | Justin Verlander | Matt Harrison | Fernando Rodney | 210 | 173 | 37 |
| 2009-05-21 | vs TEX | 39 | W 4-3 | 24-15 | 1 | 34,356 | Edwin Jackson | Kevin Millwood | Edwin Jackson | Kevin Millwood | Fernando Rodney | 214 | 176 | 38 |
| 2009-05-22 | vs COL | 40 | W 4-3 | 25-15 | 1 | 28,264 | Rick Porcello | Ubaldo Jimenez | Rick Porcello | Ubaldo Jimenez | Joel Zumaya | 218 | 179 | 39 |
| 2009-05-23 | vs COL | 41 | L 3-4 | 25-16 | 1 | 37,035 | Armando Galarraga | Jason Marquis | Jason Marquis | Armando Galarraga | Huston Street | 221 | 183 | 38 |
| 2009-05-24 | vs COL | 42 | L 1-3 | 25-17 | 1 | 34,606 | Dontrelle Willis | Jason Hammel | Jason Hammel | Dontrelle Willis | Huston Street | 222 | 186 | 36 |
| 2009-05-25 | @ KCA | 43 | W 13-1 | 26-17 | 1 | 34,524 | Justin Verlander | Gil Meche | Justin Verlander | Gil Meche | | 235 | 187 | 48 |
| 2009-05-26 | @ KCA | 44 | L 1-6 | 26-18 | 1 | 16,366 | Edwin Jackson | Zack Greinke | Zack Greinke | Edwin Jackson | | 236 | 193 | 43 |
| 2009-05-27 | @ KCA | 45 | W 8-3 | 27-18 | 1 | 16,568 | Rick Porcello | Kyle Davies | Rick Porcello | Kyle Davies | | 244 | 196 | 48 |
| 2009-05-28 | @ BAL | 46 | L 1-5 | 27-19 | 1 | 11,937 | Armando Galarraga | David Hernandez | David Hernandez | Armando Galarraga | | 245 | 201 | 44 |
| 2009-05-29 | @ BAL | 47 | L 2-7 | 27-20 | 1 | 42,704 | Dontrelle Willis | Brad Bergesen | Brad Bergesen | Dontrelle Willis | | 247 | 208 | 39 |
| 2009-05-30 | @ BAL | 48 | W 6-3 | 28-20 | 1 | 34,567 | Justin Verlander | Jeremy Guthrie | Justin Verlander | Matt Albers | Fernando Rodney | 253 | 211 | 42 |
| 2009-05-31 | @ BAL | 49 | W 3-0 | 29-20 | 1 | 32,233 | Edwin Jackson | Jason Berken | Edwin Jackson | Jason Berken | Fernando Rodney | 256 | 211 | 45 |
| 2009-06-02 | vs BOS | 50 | L 1-5 | 29-21 | 1 | 25,914 | Rick Porcello | Daisuke Matsuzaka | Daisuke Matsuzaka | Rick Porcello | | 257 | 216 | 41 |
| 2009-06-03 | vs BOS | 51 | L 5-10 | 30-21 | 1 | 29,240 | Armando Galarraga | Josh Beckett | Josh Beckett | Armando Galarraga | | 262 | 226 | 36 |
| 2009-06-04 | vs BOS | 52 | L 3-6 | 30-22 | 1 | 31,353 | Dontrelle Willis | Tim Wakefield | Tim Wakefield | Dontrelle Willis | Jonathan Papelbon | 265 | 232 | 33 |
| 2009-06-05 | vs ANA | 53 | L 1-2 | 30-23 | 1 | 31,187 | Justin Verlander | Ervin Santana | Ervin Santana | Fernando Rodney | Brian Fuentes | 266 | 234 | 32 |
| 2009-06-06 | vs ANA | 54 | W 2-1 | 31-23 | 1 | 32,367 | Edwin Jackson | Kelvim Escobar | Edwin Jackson | Kelvim Escobar | | 268 | 235 | 33 |
| 2009-06-07 | vs ANA | 55 | W 9-6 | 32-23 | 1 | 32,074 | Rick Porcello | Joe Saunders | Joel Zumaya | Jose Arredondo | | 277 | 241 | 36 |
| 2009-06-08 | @ CHA | 56 | W 5-4 | 33-24 | 2 | 24,408 | Armando Galarraga | Clayton Richard | Joel Zumaya | Scott Linebrink | Fernando Rodney | 282 | 245 | 37 |
| 2009-06-08 | @ CHA | 57 | L 1-6 | 33-24 | 2 | 30,809 | Jeremy Bonderman | Jose Contreras | Jose Contreras | Jeremy Bonderman | | 283 | 251 | 32 |
| 2009-06-09 | @ CHA | 58 | W 7-6 | 34-24 | 1 | 25,676 | Dontrelle Willis | Mark Buehrle | Brandon Lyon | Scott Linebrink | | 290 | 257 | 33 |
| 2009-06-10 | @ CHA | 59 | W 2-1 | 35-24 | 1 | 28,079 | Justin Verlander | John Danks | Justin Verlander | John Danks | | 292 | 258 | 34 |
| 2009-06-11 | @ CHA | 60 | L 3-4 | 35-25 | 1 | 20,824 | Edwin Jackson | Gavin Floyd | Bobby Jenks | Joel Zumaya | | 295 | 262 | 33 |
| 2009-06-12 | @ PIT | 61 | W 3-1 | 36-25 | 1 | 18,369 | Rick Porcello | Ian Snell | Rick Porcello | Ian Snell | Fernando Rodney | 298 | 263 | 35 |
| 2009-06-13 | @ PIT | 62 | L 3-9 | 36-26 | 1 | 31,411 | Armando Galarraga | Zach Duke | Zach Duke | Armando Galarraga | | 301 | 272 | 29 |
| 2009-06-14 | @ PIT | 63 | L 3-6 | 36-27 | 1 | 27,565 | Dontrelle Willis | Ross Ohlendorf | Ross Ohlendorf | Dontrelle Willis | Matt Capps | 304 | 278 | 26 |
| 2009-06-16 | @ SLN | 64 | L 2-11 | 37-27 | 1 | 44,021 | Justin Verlander | Adam Wainwright | Adam Wainwright | Justin Verlander | | 306 | 289 | 17 |
| 2009-06-17 | @ SLN | 65 | L 3-4 | 37-28 | 1 | 39,699 | Edwin Jackson | Todd Wellemeyer | Todd Wellemeyer | Edwin Jackson | Ryan Franklin | 309 | 293 | 16 |
| 2009-06-18 | @ SLN | 66 | W 6-3 | 38-28 | 1 | 41,323 | Rick Porcello | Joel Pineiro | Rick Porcello | Joel Pineiro | Fernando Rodney | 315 | 296 | 19 |
| 2009-06-19 | vs MIL | 67 | W 10-4 | 38-29 | 1 | 34,112 | Armando Galarraga | Braden Looper | Zach Miner | Braden Looper | | 325 | 300 | 25 |
| 2009-06-20 | vs MIL | 68 | W 9-5 | 39-29 | 1 | 39,156 | Alfredo Figaro | David Bush | Alfredo Figaro | David Bush | | 334 | 305 | 29 |
| 2009-06-21 | vs MIL | 69 | W 3-2 | 40-29 | 1 | 41,163 | Justin Verlander | Yovani Gallardo | Justin Verlander | Yovani Gallardo | Fernando Rodney | 337 | 307 | 30 |
| 2009-06-23 | vs CHN | 70 | W 5-4 | 41-29 | 1 | 38,046 | Edwin Jackson | Carlos Zambrano | Brandon Lyon | Kevin Gregg | | 342 | 311 | 31 |
| 2009-06-24 | vs CHN | 71 | W 5-3 | 42-29 | 1 | 36,438 | Rick Porcello | Rich Harden | Zach Miner | Rich Harden | Fernando Rodney | 347 | 314 | 33 |
| 2009-06-25 | vs CHN | 72 | W 6-5 | 43-29 | 1 | 42,332 | Armando Galarraga | Ted Lilly | Armando Galarraga | Ted Lilly | Fernando Rodney | 353 | 319 | 34 |
| 2009-06-26 | @ HOU | 73 | L 4-5 | 43-30 | 1 | 33,052 | Justin Verlander | Wandy Rodriguez | Chris Sampson | Joel Zumaya | LaTroy Hawkins | 357 | 324 | 33 |
| 2009-06-27 | @ HOU | 74 | L 1-8 | 43-31 | 1 | 37,123 | Alfredo Figaro | Felipe Paulino | Felipe Paulino | Alfredo Figaro | | 358 | 332 | 26 |
| 2009-06-28 | @ HOU | 75 | W 4-3 | 44-31 | 1 | 34,041 | Edwin Jackson | Russ Ortiz | Bobby Seay | Jose Valverde | Fernando Rodney | 362 | 335 | 27 |
| 2009-06-29 | @ OAK | 76 | L 1-7 | 44-32 | 1 | 10,563 | Rick Porcello | Brett Anderson | Brett Anderson | Rick Porcello | | 363 | 342 | 21 |
| 2009-06-30 | @ OAK | 77 | W 5-3 | 45-32 | 1 | 12,126 | Armando Galarraga | Gio Gonzalez | Armando Galarraga | Gio Gonzalez | | 368 | 345 | 23 |
| 2009-07-01 | @ OAK | 78 | L 1-5 | 45-33 | 1 | 21,238 | Justin Verlander | Dallas Braden | Dallas Braden | Justin Verlander | | 369 | 350 | 19 |
| 2009-07-03 | @ MIN | 79 | W 11-9 | 45-34 | 1 | 33,368 | Lucas French | Kevin Slowey | Freddy Dolsi | R.A. Dickey | | 380 | 359 | 21 |
| 2009-07-04 | @ MIN | 80 | L 3-4 | 45-35 | 1 | 27,238 | Edwin Jackson | Francisco Liriano | Matt Guerrier | Brandon Lyon | Joe Nathan | 383 | 363 | 20 |
| 2009-07-05 | @ MIN | 81 | L 2-6 | 45-36 | 1 | 33,274 | Rick Porcello | Nick Blackburn | Nick Blackburn | Rick Porcello | | 385 | 369 | 16 |
| 2009-07-06 | vs KCA | 82 | L 3-4 | 45-37 | 1 | 32,134 | Armando Galarraga | Gil Meche | Roman Colon | Fernando Rodney | Joakim Soria | 388 | 373 | 15 |
| 2009-07-07 | vs KCA | 83 | W 8-5 | 46-37 | 1 | 29,751 | Justin Verlander | Bruce Chen | Justin Verlander | Bruce Chen | Fernando Rodney | 396 | 378 | 18 |
| 2009-07-08 | vs KCA | 84 | W 3-1 | 47-37 | 1 | 29,104 | Lucas French | Zack Greinke | Lucas French | Zack Greinke | Fernando Rodney | 399 | 379 | 20 |
| 2009-07-10 | vs CLE | 85 | W 5-1 | 48-37 | 1 | 35,592 | Edwin Jackson | Cliff Lee | Edwin Jackson | Cliff Lee | | 404 | 380 | 24 |
| 2009-07-11 | vs CLE | 86 | L 4-5 | 48-38 | 1 | 41,782 | Armando Galarraga | Carl Pavano | Carl Pavano | Armando Galarraga | Kerry Wood | 408 | 385 | 23 |
| 2009-07-12 | vs CLE | 87 | W 10-1 | 49-38 | 1 | 39,680 | Justin Verlander | Tomo Ohka | Justin Verlander | Tomo Ohka | | 418 | 386 | 32 |
| 2009-07-17 | @ NYA | 88 | L 3-5 | 49-39 | 1 | 46,197 | Lucas French | A.J. Burnett | Phil Hughes | Joel Zumaya | Mariano Rivera | 421 | 391 | 30 |
| 2009-07-18 | @ NYA | 89 | L 1-2 | 49-40 | 1 | 46,423 | Justin Verlander | CC Sabathia | CC Sabathia | Justin Verlander | Mariano Rivera | 422 | 393 | 29 |
| 2009-07-19 | @ NYA | 90 | L 1-2 | 49-41 | 1 | 46,937 | Edwin Jackson | Joba Chamberlain | Joba Chamberlain | Edwin Jackson | Mariano Rivera | 423 | 395 | 28 |
| 2009-07-21 | vs SEA | 91 | W 9-7 | 50-41 | 1 | 32,906 | Rick Porcello | Garrett Olson | Rick Porcello | Garrett Olson | Fernando Rodney | 432 | 402 | 30 |
| 2009-07-22 | vs SEA | 92 | L 1-2 | 50-42 | 1 | 29,758 | Armando Galarraga | Felix Hernandez | Felix Hernandez | Bobby Seay | David Aardsma | 433 | 404 | 29 |
| 2009-07-23 | vs SEA | 93 | L 1-2 | 50-43 | 1 | 32,177 | Lucas French | Jarrod Washburn | Jarrod Washburn | Lucas French | David Aardsma | 434 | 406 | 28 |
| 2009-07-24 | vs CHA | 94 | W 5-1 | 51-43 | 2 | 27,844 | Justin Verlander | Jose Contreras | Justin Verlander | Jose Contreras | | 439 | 407 | 32 |
| 2009-07-24 | vs CHA | 95 | W 4-3 | 51-43 | 2 | 39,375 | Eddie Bonine | Bartolo Colon | Brandon Lyon | Scott Linebrink | Fernando Rodney | 443 | 410 | 33 |
| 2009-07-25 | vs CHA | 96 | W 4-3 | 53-43 | 1 | 41,378 | Edwin Jackson | Gavin Floyd | Fernando Rodney | D.J. Carrasco | | 447 | 413 | 34 |
| 2009-07-26 | vs CHA | 97 | L 1-5 | 53-44 | 1 | 38,255 | Rick Porcello | Clayton Richard | Clayton Richard | Rick Porcello | | 448 | 418 | 30 |
| 2009-07-27 | @ TEX | 98 | L 2-5 | 53-45 | 1 | 17,173 | Armando Galarraga | Tommy Hunter | Tommy Hunter | Armando Galarraga | C.J. Wilson | 450 | 423 | 27 |
| 2009-07-28 | @ TEX | 99 | L 3-7 | 53-46 | 1 | 21,615 | Lucas French | Doug Mathis | Jason Grilli | Lucas French | | 453 | 430 | 23 |
| 2009-07-29 | @ TEX | 100 | W 13-5 | 53-47 | 1 | 33,235 | Justin Verlander | Scott Feldman | Justin Verlander | Scott Feldman | | 466 | 435 | 31 |
| 2009-07-31 | @ CLE | 101 | L 5-6 | 53-48 | 1 | 35,273 | Edwin Jackson | Fausto Carmona | Tomo Ohka | Casey Fien | | 471 | 441 | 30 |
| 2009-08-01 | @ CLE | 102 | W 4-3 | 54-48 | 1 | 31,353 | Rick Porcello | Jeremy Sowers | Bobby Seay | Jose Veras | Zach Miner | 475 | 444 | 31 |
| 2009-08-02 | @ CLE | 103 | L 1-11 | 54-49 | 1 | 24,718 | Armando Galarraga | Carl Pavano | Carl Pavano | Armando Galarraga | | 476 | 455 | 21 |
| 2009-08-03 | vs BAL | 104 | W 6-5 | 55-49 | 1 | 27,857 | Justin Verlander | Chris Tillman | Fernando Rodney | Danys Baez | | 482 | 460 | 22 |
| 2009-08-04 | vs BAL | 105 | L 2-8 | 55-50 | 1 | 29,295 | Jarrod Washburn | Brian Matusz | Brian Matusz | Jarrod Washburn | | 484 | 468 | 16 |
| 2009-08-05 | vs BAL | 106 | W 4-2 | 56-50 | 1 | 28,978 | Edwin Jackson | Jeremy Guthrie | Edwin Jackson | Jeremy Guthrie | Fernando Rodney | 488 | 470 | 18 |
| 2009-08-06 | vs BAL | 107 | W 7-3 | 57-50 | 1 | 31,165 | Rick Porcello | David Hernandez | Rick Porcello | David Hernandez | Brandon Lyon | 495 | 473 | 22 |
| 2009-08-07 | vs MIN | 108 | W 10-8 | 57-51 | 1 | 36,444 | Armando Galarraga | Anthony Swarzak | Armando Galarraga | Anthony Swarzak | | 505 | 481 | 24 |
| 2009-08-08 | vs MIN | 109 | L 0-11 | 57-52 | 1 | 39,685 | Justin Verlander | Carl Pavano | Carl Pavano | Justin Verlander | | 505 | 492 | 13 |
| 2009-08-09 | vs MIN | 110 | W 8-7 | 58-52 | 1 | 35,423 | Jarrod Washburn | Scott Baker | Brandon Lyon | Matt Guerrier | Fernando Rodney | 513 | 499 | 14 |
| 2009-08-10 | @ BOS | 111 | L 5-6 | 58-53 | 1 | 37,960 | Edwin Jackson | Brad Penny | Ramon Ramirez | Zach Miner | Jonathan Papelbon | 518 | 505 | 13 |
| 2009-08-11 | @ BOS | 112 | L 5-7 | 58-54 | 1 | 38,013 | Rick Porcello | Junichi Tazawa | Junichi Tazawa | Chris Lambert | | 523 | 512 | 11 |
| 2009-08-12 | @ BOS | 113 | L 2-8 | 58-55 | 2 | 38,124 | Zach Miner | Josh Beckett | Josh Beckett | Zach Miner | | 525 | 520 | 5 |
| 2009-08-13 | @ BOS | 114 | W 2-0 | 59-55 | 1 | 37,556 | Justin Verlander | Clay Buchholz | Justin Verlander | Clay Buchholz | Fernando Rodney | 527 | 520 | 7 |
| 2009-08-14 | vs KCA | 115 | W 1-0 | 60-55 | 1 | 34,799 | Jarrod Washburn | Zack Greinke | Brandon Lyon | Roman Colon | | 528 | 520 | 8 |
| 2009-08-15 | vs KCA | 116 | W 10-3 | 60-56 | 1 | 37,276 | Edwin Jackson | Luke Hochevar | Edwin Jackson | Luke Hochevar | | 538 | 523 | 15 |
| 2009-08-16 | vs KCA | 117 | L 2-3 | 60-57 | 1 | 32,888 | Armando Galarraga | Kyle Davies | Joakim Soria | Fernando Rodney | | 540 | 526 | 14 |
| 2009-08-18 | vs SEA | 118 | W 5-3 | 61-57 | 1 | 33,710 | Rick Porcello | Felix Hernandez | Bobby Seay | Mark Lowe | Fernando Rodney | 545 | 529 | 16 |
| 2009-08-19 | vs SEA | 119 | L 1-3 | 61-58 | 2 | 33,194 | Justin Verlander | Ian Snell | Ian Snell | Justin Verlander | David Aardsma | 546 | 532 | 14 |
| 2009-08-20 | vs SEA | 120 | W 7-6 | 62-58 | 1 | 31,167 | Jarrod Washburn | Ryan Rowland-Smith | Bobby Seay | David Aardsma | | 553 | 538 | 15 |
| 2009-08-21 | @ OAK | 121 | W 3-2 | 63-58 | 1 | 15,927 | Edwin Jackson | Gio Gonzalez | Edwin Jackson | Gio Gonzalez | Fernando Rodney | 556 | 540 | 16 |
| 2009-08-22 | @ OAK | 122 | L 2-3 | 63-59 | 2 | 26,266 | Armando Galarraga | Trevor Cahill | Andrew Bailey | Zach Miner | | 558 | 543 | 15 |
| 2009-08-23 | @ OAK | 123 | L 4-9 | 63-60 | 2 | 17,690 | Rick Porcello | Brett Tomko | Brett Tomko | Rick Porcello | | 562 | 552 | 10 |
| 2009-08-24 | @ ANA | 124 | W 10-7 | 63-61 | 2 | 38,421 | Justin Verlander | Jered Weaver | Justin Verlander | Jered Weaver | Fernando Rodney | 572 | 559 | 13 |
| 2009-08-25 | @ ANA | 125 | W 5-3 | 64-61 | 2 | 42,970 | Jarrod Washburn | John Lackey | Jarrod Washburn | John Lackey | Fernando Rodney | 577 | 562 | 15 |
| 2009-08-26 | @ ANA | 126 | L 2-4 | 64-62 | 2 | 36,329 | Edwin Jackson | Joe Saunders | Joe Saunders | Edwin Jackson | Brian Fuentes | 579 | 566 | 13 |
| 2009-08-28 | vs TBA | 127 | W 6-2 | 65-62 | 2 | 35,030 | Rick Porcello | Matt Garza | Rick Porcello | Matt Garza | | 585 | 568 | 17 |
| 2009-08-29 | vs TBA | 128 | L 1-3 | 65-63 | 2 | 39,296 | Nate Robertson | David Price | David Price | Nate Robertson | J.P. Howell | 586 | 571 | 15 |
| 2009-08-30 | vs TBA | 129 | W 4-3 | 66-63 | 2 | 36,067 | Justin Verlander | Jeff Niemann | Justin Verlander | Grant Balfour | Fernando Rodney | 590 | 574 | 16 |
| 2009-08-31 | vs TBA | 130 | L 7-11 | 67-63 | 2 | 26,533 | Jarrod Washburn | James Shields | James Shields | Jarrod Washburn | | 597 | 585 | 12 |
| 2009-09-01 | vs CLE | 131 | W 8-5 | 68-63 | 2 | 24,225 | Edwin Jackson | Carlos Carrasco | Edwin Jackson | Carlos Carrasco | Fernando Rodney | 605 | 590 | 15 |
| 2009-09-02 | vs CLE | 132 | W 4-2 | 69-63 | 2 | 25,840 | Rick Porcello | Aaron Laffey | Rick Porcello | Aaron Laffey | Fernando Rodney | 609 | 592 | 17 |
| 2009-09-03 | vs CLE | 133 | W 4-3 | 70-63 | 1 | 28,267 | Nate Robertson | Fausto Carmona | Zach Miner | Rafael Perez | | 613 | 595 | 18 |
| 2009-09-04 | @ TBA | 134 | W 4-3 | 71-63 | 1 | 18,596 | Justin Verlander | Jeff Niemann | Justin Verlander | J.P. Howell | Fernando Rodney | 617 | 598 | 19 |
| 2009-09-05 | @ TBA | 135 | W 8-6 | 72-63 | 1 | 36,973 | Armando Galarraga | James Shields | Bobby Seay | Grant Balfour | Brandon Lyon | 625 | 604 | 21 |
| 2009-09-06 | @ TBA | 136 | W 5-3 | 73-63 | 1 | 28,059 | Edwin Jackson | Wade Davis | Edwin Jackson | Russ Springer | Brandon Lyon | 630 | 607 | 23 |
| 2009-09-08 | @ KCA | 137 | L 5-7 | 73-64 | 1 | 12,032 | Rick Porcello | Bruce Chen | Yasuhiko Yabuta | Bobby Seay | Joakim Soria | 635 | 614 | 21 |
| 2009-09-09 | @ KCA | 138 | L 1-5 | 73-65 | 1 | 10,584 | Justin Verlander | Rob Tejeda | Rob Tejeda | Justin Verlander | Joakim Soria | 636 | 619 | 17 |
| 2009-09-10 | @ KCA | 139 | L 4-7 | 73-66 | 1 | 12,029 | Jarrod Washburn | Lenny DiNardo | Roman Colon | Zach Miner | Carlos Rosa | 640 | 626 | 14 |
| 2009-09-11 | vs TOR | 140 | L 4-6 | 73-67 | 2 | 31,575 | Nate Robertson | Brian Tallet | Brian Tallet | Nate Robertson | Jason Frasor | 644 | 632 | 12 |
| 2009-09-12 | vs TOR | 141 | L 6-8 | 73-68 | 2 | 36,142 | Edwin Jackson | Scott Richmond | Brandon League | Fernando Rodney | Jason Frasor | 650 | 640 | 10 |
| 2009-09-13 | vs TOR | 142 | W 7-2 | 74-68 | 2 | 32,468 | Rick Porcello | Ricky Romero | Rick Porcello | Ricky Romero | | 657 | 642 | 15 |
| 2009-09-14 | vs TOR | 143 | W 6-5 | 75-68 | 2 | 24,375 | Justin Verlander | David Purcey | Bobby Seay | Brian Wolfe | | 663 | 647 | 16 |
| 2009-09-15 | vs KCA | 144 | L 1-11 | 75-69 | 2 | 20,422 | Jarrod Washburn | Rob Tejeda | Rob Tejeda | Jarrod Washburn | | 664 | 658 | 6 |
| 2009-09-16 | vs KCA | 145 | W 4-3 | 76-69 | 2 | 25,400 | Eddie Bonine | Lenny DiNardo | Zach Miner | Lenny DiNardo | Fernando Rodney | 668 | 661 | 7 |
| 2009-09-17 | vs KCA | 146 | L 2-9 | 76-70 | 2 | 26,457 | Edwin Jackson | Zack Greinke | Zack Greinke | Edwin Jackson | | 670 | 670 | 0 |
| 2009-09-18 | @ MIN | 147 | L 0-3 | 76-71 | 2 | 32,693 | Rick Porcello | Brian Duensing | Brian Duensing | Rick Porcello | Joe Nathan | 670 | 673 | -3 |
| 2009-09-19 | @ MIN | 148 | L 2-6 | 76-72 | 2 | 43,338 | Justin Verlander | Carl Pavano | Jesse Crain | Justin Verlander | | 672 | 679 | -7 |
| 2009-09-20 | @ MIN | 149 | W 6-2 | 77-72 | 2 | 36,335 | Nate Robertson | Scott Baker | Nate Robertson | Scott Baker | | 678 | 681 | -3 |
| 2009-09-22 | @ CLE | 150 | W 3-1 | 78-72 | 2 | 23,217 | Edwin Jackson | Aaron Laffey | Edwin Jackson | Aaron Laffey | Fernando Rodney | 681 | 682 | -1 |
| 2009-09-23 | @ CLE | 151 | W 11-3 | 78-73 | 2 | 13,971 | Rick Porcello | Justin Masterson | Rick Porcello | Justin Masterson | | 692 | 685 | 7 |
| 2009-09-24 | @ CLE | 152 | W 6-5 | 79-73 | 2 | 23,516 | Justin Verlander | Carlos Carrasco | Justin Verlander | Carlos Carrasco | Fernando Rodney | 698 | 690 | 8 |
| 2009-09-25 | @ CHA | 153 | L 0-2 | 79-74 | 2 | 30,794 | Eddie Bonine | Jake Peavy | Jake Peavy | Eddie Bonine | Matt Thornton | 698 | 692 | 6 |
| 2009-09-26 | @ CHA | 154 | W 12-5 | 79-75 | 2 | 35,590 | Nate Robertson | Freddy Garcia | Alfredo Figaro | Freddy Garcia | | 710 | 697 | 13 |
| 2009-09-27 | @ CHA | 155 | L 4-8 | 79-76 | 2 | 33,685 | Edwin Jackson | Daniel Hudson | Daniel Hudson | Edwin Jackson | Matt Thornton | 714 | 705 | 9 |
| 2009-09-29 | vs MIN | 156 | L 2-3 | 79-77 | 4 | 35,243 | Rick Porcello | Nick Blackburn | Jon Rauch | Brandon Lyon | Joe Nathan | 716 | 708 | 8 |
| 2009-09-29 | vs MIN | 157 | W 6-5 | 79-77 | 4 | 30,240 | Justin Verlander | Brian Duensing | Justin Verlander | Brian Duensing | Fernando Rodney | 722 | 713 | 9 |
| 2009-09-30 | vs MIN | 158 | W 7-2 | 81-77 | 2 | 34,775 | Eddie Bonine | Carl Pavano | Eddie Bonine | Carl Pavano | | 729 | 715 | 14 |
| 2009-10-01 | vs MIN | 159 | L 3-8 | 81-78 | 2 | 40,533 | Nate Robertson | Scott Baker | Scott Baker | Nate Robertson | | 732 | 723 | 9 |
| 2009-10-02 | vs CHA | 160 | L 0-8 | 81-79 | 2 | 34,726 | Edwin Jackson | Jake Peavy | Jake Peavy | Edwin Jackson | | 732 | 731 | 1 |
| 2009-10-03 | vs CHA | 161 | L 1-5 | 81-80 | 2 | 35,184 | Alfredo Figaro | Freddy Garcia | Freddy Garcia | Alfredo Figaro | | 733 | 736 | -3 |
| 2009-10-04 | vs CHA | 162 | W 5-3 | 82-80 | 2 | 35,806 | Justin Verlander | John Danks | Justin Verlander | John Danks | Fernando Rodney | 738 | 739 | -1 |
| 2009-10-06 | @ MIN | 163 | L 5-6 | 82-81 | 2 | 54,088 | Rick Porcello | Scott Baker | Bobby Keppel | Fernando Rodney | | 743 | 745 | -2 |