| 2009-04-06 | vs OAK | 1 | W 3-0 | 1-0 | 1 | 43,220 | Joe Saunders | Dallas Braden | Joe Saunders | Dallas Braden | Brian Fuentes | 3 | 0 | 3 |
| 2009-04-07 | vs OAK | 2 | L 4-6 | 1-1 | 2 | 43,396 | Dustin Moseley | Trevor Cahill | Michael Wuertz | Kevin Jepsen | Brad Ziegler | 7 | 6 | 1 |
| 2009-04-08 | vs OAK | 3 | L 4-6 | 1-2 | 3 | 43,283 | Nick Adenhart | Dana Eveland | Andrew Bailey | Brian Fuentes | Brad Ziegler | 11 | 12 | -1 |
| 2009-04-10 | vs BOS | 4 | W 6-3 | 2-2 | 3 | 41,385 | Jered Weaver | Tim Wakefield | Jered Weaver | Tim Wakefield | Scot Shields | 17 | 15 | 2 |
| 2009-04-11 | vs BOS | 5 | L 4-5 | 2-3 | 3 | 40,163 | Joe Saunders | Brad Penny | Brad Penny | Joe Saunders | Jonathan Papelbon | 21 | 20 | 1 |
| 2009-04-12 | vs BOS | 6 | W 5-4 | 3-3 | 2 | 38,076 | Dustin Moseley | Josh Beckett | Dustin Moseley | Josh Beckett | Brian Fuentes | 26 | 24 | 2 |
| 2009-04-14 | @ SEA | 7 | L 2-3 | 3-4 | 4 | 45,958 | Shane Loux | Carlos Silva | Roy Corcoran | Scot Shields | | 28 | 27 | 1 |
| 2009-04-15 | @ SEA | 8 | L 3-11 | 4-4 | 2 | 18,516 | Jered Weaver | Jarrod Washburn | Jarrod Washburn | Jered Weaver | | 31 | 38 | -7 |
| 2009-04-16 | @ SEA | 9 | W 5-1 | 5-4 | 2 | 18,528 | Joe Saunders | Chris Jakubauskas | Joe Saunders | Chris Jakubauskas | | 36 | 39 | -3 |
| 2009-04-17 | @ MIN | 10 | L 9-11 | 6-4 | 2 | 24,168 | Dustin Moseley | Nick Blackburn | Matt Guerrier | Jason Bulger | Joe Nathan | 45 | 50 | -5 |
| 2009-04-18 | @ MIN | 11 | L 2-9 | 6-5 | 2 | 34,286 | Darren Oliver | Kevin Slowey | Kevin Slowey | Kevin Jepsen | | 47 | 59 | -12 |
| 2009-04-19 | @ MIN | 12 | L 1-3 | 6-6 | 2 | 28,302 | Shane Loux | Glen Perkins | Glen Perkins | Shane Loux | Joe Nathan | 48 | 62 | -14 |
| 2009-04-21 | vs DET | 13 | W 4-3 | 7-6 | 2 | 41,627 | Jered Weaver | Armando Galarraga | Jose Arredondo | Brandon Lyon | Brian Fuentes | 52 | 65 | -13 |
| 2009-04-22 | vs DET | 14 | L 10-12 | 7-7 | 2 | 43,047 | Joe Saunders | Justin Verlander | Juan Rincon | Scot Shields | | 62 | 77 | -15 |
| 2009-04-23 | vs DET | 15 | W 10-5 | 7-8 | 2 | 38,543 | Matt Palmer | Edwin Jackson | Matt Palmer | Edwin Jackson | | 72 | 82 | -10 |
| 2009-04-24 | vs SEA | 16 | L 3-8 | 7-9 | 3 | 43,083 | Shane Loux | Erik Bedard | Erik Bedard | Shane Loux | | 75 | 90 | -15 |
| 2009-04-25 | vs SEA | 17 | L 8-9 | 7-10 | 3 | 43,542 | Anthony Ortega | Carlos Silva | Carlos Silva | Anthony Ortega | David Aardsma | 83 | 99 | -16 |
| 2009-04-26 | vs SEA | 18 | W 8-0 | 8-10 | 3 | 43,057 | Jered Weaver | Jarrod Washburn | Jered Weaver | Jarrod Washburn | | 91 | 99 | -8 |
| 2009-04-28 | @ BAL | 19 | W 7-5 | 9-10 | 4 | 11,857 | Joe Saunders | Adam Eaton | Joe Saunders | Adam Eaton | Brian Fuentes | 98 | 104 | -6 |
| 2009-04-29 | @ BAL | 20 | W 3-2 | 10-10 | 3 | 14,203 | Shane Loux | Koji Uehara | Shane Loux | Koji Uehara | Brian Fuentes | 101 | 106 | -5 |
| 2009-04-30 | @ NYA | 21 | L 4-7 | 10-11 | 3 | 43,388 | Anthony Ortega | A.J. Burnett | Phil Coke | Justin Speier | Mariano Rivera | 105 | 113 | -8 |
| 2009-05-01 | @ NYA | 22 | L 9-10 | 11-11 | 2 | 44,058 | Jered Weaver | Andy Pettitte | Jonathan Albaladejo | Brian Fuentes | | 114 | 123 | -9 |
| 2009-05-02 | @ NYA | 23 | W 8-4 | 12-11 | 2 | 44,970 | Matt Palmer | CC Sabathia | Matt Palmer | CC Sabathia | | 122 | 127 | -5 |
| 2009-05-04 | @ OAK | 24 | W 5-2 | 13-11 | 2 | 10,397 | Joe Saunders | Brett Anderson | Joe Saunders | Brett Anderson | Brian Fuentes | 127 | 129 | -2 |
| 2009-05-05 | @ OAK | 25 | W 5-3 | 14-11 | 2 | 13,298 | Shane Loux | Dallas Braden | Shane Loux | Dallas Braden | Brian Fuentes | 132 | 132 | 0 |
| 2009-05-06 | vs TOR | 26 | L 1-13 | 14-12 | 2 | 41,123 | Anthony Ortega | Roy Halladay | Roy Halladay | Anthony Ortega | | 133 | 145 | -12 |
| 2009-05-07 | vs TOR | 27 | W 6-1 | 15-12 | 2 | 41,007 | Jered Weaver | Robert Ray | Jered Weaver | Robert Ray | | 139 | 146 | -7 |
| 2009-05-08 | vs KCA | 28 | W 4-1 | 16-12 | 2 | 41,019 | Matt Palmer | Gil Meche | Matt Palmer | Gil Meche | Brian Fuentes | 143 | 147 | -4 |
| 2009-05-09 | vs KCA | 29 | W 1-0 | 17-12 | 1 | 39,776 | Joe Saunders | Zack Greinke | Joe Saunders | Zack Greinke | | 144 | 147 | -3 |
| 2009-05-10 | vs KCA | 30 | W 4-3 | 18-12 | 1 | 43,646 | Shane Loux | Kyle Davies | Scot Shields | Jamey Wright | Brian Fuentes | 148 | 150 | -2 |
| 2009-05-12 | vs BOS | 31 | L 3-4 | 18-13 | 2 | 33,411 | Jered Weaver | Justin Masterson | Ramon Ramirez | Scot Shields | Jonathan Papelbon | 151 | 154 | -3 |
| 2009-05-13 | vs BOS | 32 | W 8-4 | 19-13 | 2 | 35,666 | Matt Palmer | Tim Wakefield | Matt Palmer | Tim Wakefield | | 159 | 158 | 1 |
| 2009-05-14 | vs BOS | 33 | W 5-4 | 20-13 | 2 | 35,124 | Ervin Santana | Brad Penny | Jason Bulger | Manny Delcarmen | | 164 | 162 | 2 |
| 2009-05-15 | @ TEX | 34 | L 8-10 | 21-13 | 1 | 33,429 | Joe Saunders | Kevin Millwood | Kevin Millwood | Joe Saunders | C.J. Wilson | 172 | 172 | 0 |
| 2009-05-16 | @ TEX | 35 | L 3-5 | 21-14 | 2 | 34,284 | John Lackey | Vicente Padilla | Vicente Padilla | Shane Loux | C.J. Wilson | 175 | 177 | -2 |
| 2009-05-17 | @ TEX | 36 | L 0-3 | 21-15 | 2 | 37,146 | Jered Weaver | Scott Feldman | Jason Jennings | Jered Weaver | Darren O'Day | 175 | 180 | -5 |
| 2009-05-18 | @ SEA | 37 | W 10-6 | 21-16 | 2 | 17,340 | John Lackey | Jarrod Washburn | John Lackey | Jarrod Washburn | | 185 | 186 | -1 |
| 2009-05-19 | @ SEA | 38 | W 6-5 | 22-16 | 2 | 16,002 | Matt Palmer | Felix Hernandez | Matt Palmer | Felix Hernandez | Brian Fuentes | 191 | 191 | 0 |
| 2009-05-20 | @ SEA | 39 | L 0-1 | 22-17 | 2 | 18,580 | Ervin Santana | Chris Jakubauskas | Chris Jakubauskas | Ervin Santana | David Aardsma | 191 | 192 | -1 |
| 2009-05-21 | @ SEA | 40 | W 3-0 | 23-17 | 1 | 18,468 | Joe Saunders | Erik Bedard | Joe Saunders | Erik Bedard | Brian Fuentes | 194 | 192 | 2 |
| 2009-05-22 | @ LAN | 41 | W 3-1 | 24-17 | 1 | 55,053 | Jered Weaver | Clayton Kershaw | Darren Oliver | Cory Wade | Brian Fuentes | 197 | 193 | 4 |
| 2009-05-23 | @ LAN | 42 | L 4-5 | 24-18 | 2 | 55,301 | John Lackey | Randy Wolf | Jonathan Broxton | Jose Arredondo | | 201 | 198 | 3 |
| 2009-05-24 | @ LAN | 43 | W 10-7 | 24-19 | 2 | 54,122 | Matt Palmer | Chad Billingsley | Jason Bulger | Chad Billingsley | | 211 | 205 | 6 |
| 2009-05-25 | vs CHA | 44 | L 3-17 | 25-19 | 2 | 43,177 | Ervin Santana | John Danks | John Danks | Ervin Santana | | 214 | 222 | -8 |
| 2009-05-26 | vs CHA | 45 | L 2-4 | 25-20 | 2 | 38,040 | Joe Saunders | Bartolo Colon | Bartolo Colon | Joe Saunders | Scott Linebrink | 216 | 226 | -10 |
| 2009-05-27 | vs CHA | 46 | W 3-1 | 26-20 | 2 | 40,169 | Jered Weaver | Gavin Floyd | Jered Weaver | Gavin Floyd | Brian Fuentes | 219 | 227 | -8 |
| 2009-05-29 | vs SEA | 47 | L 2-5 | 26-21 | 3 | 38,492 | John Lackey | Jason Vargas | Jason Vargas | John Lackey | David Aardsma | 221 | 232 | -11 |
| 2009-05-30 | vs SEA | 48 | L 3-4 | 26-22 | 2 | 39,329 | Matt Palmer | Felix Hernandez | Miguel Batista | Jose Arredondo | David Aardsma | 224 | 236 | -12 |
| 2009-05-31 | vs SEA | 49 | W 9-8 | 27-22 | 2 | 38,632 | Ervin Santana | Garrett Olson | Justin Speier | David Aardsma | | 233 | 244 | -11 |
| 2009-06-02 | @ TOR | 50 | L 4-6 | 27-23 | 2 | 26,809 | Joe Saunders | Roy Halladay | Roy Halladay | Joe Saunders | | 237 | 250 | -13 |
| 2009-06-03 | @ TOR | 51 | W 8-1 | 28-23 | 2 | 17,127 | Jered Weaver | Casey Janssen | Jered Weaver | Casey Janssen | | 245 | 251 | -6 |
| 2009-06-04 | @ TOR | 52 | W 6-5 | 29-23 | 2 | 31,163 | John Lackey | Brian Tallet | Justin Speier | Brandon League | Brian Fuentes | 251 | 256 | -5 |
| 2009-06-05 | @ DET | 53 | W 2-1 | 30-23 | 2 | 31,187 | Ervin Santana | Justin Verlander | Ervin Santana | Fernando Rodney | Brian Fuentes | 253 | 257 | -4 |
| 2009-06-06 | @ DET | 54 | L 1-2 | 30-24 | 2 | 32,367 | Kelvim Escobar | Edwin Jackson | Edwin Jackson | Kelvim Escobar | | 254 | 259 | -5 |
| 2009-06-07 | @ DET | 55 | L 6-9 | 30-25 | 2 | 32,074 | Joe Saunders | Rick Porcello | Joel Zumaya | Jose Arredondo | | 260 | 268 | -8 |
| 2009-06-09 | @ TBA | 56 | W 4-3 | 31-25 | 2 | 16,087 | Jered Weaver | James Shields | Jered Weaver | James Shields | Brian Fuentes | 264 | 271 | -7 |
| 2009-06-10 | @ TBA | 57 | L 5-9 | 31-26 | 2 | 15,658 | John Lackey | Jeff Niemann | Lance Cormier | John Lackey | | 269 | 280 | -11 |
| 2009-06-11 | @ TBA | 58 | L 1-11 | 31-27 | 2 | 17,086 | Ervin Santana | David Price | Grant Balfour | Ervin Santana | | 270 | 291 | -21 |
| 2009-06-12 | vs SDN | 59 | W 11-6 | 31-28 | 2 | 41,597 | Matt Palmer | Chad Gaudin | Matt Palmer | Chad Gaudin | | 281 | 297 | -16 |
| 2009-06-13 | vs SDN | 60 | W 9-1 | 32-28 | 2 | 43,233 | Joe Saunders | Josh Geer | Joe Saunders | Josh Geer | | 290 | 298 | -8 |
| 2009-06-14 | vs SDN | 61 | W 6-0 | 33-28 | 2 | 40,163 | Jered Weaver | Chris Young | Jered Weaver | Chris Young | | 296 | 298 | -2 |
| 2009-06-15 | @ SFN | 62 | W 9-7 | 34-28 | 2 | 33,613 | John Lackey | Barry Zito | John Lackey | Barry Zito | Brian Fuentes | 305 | 305 | 0 |
| 2009-06-16 | @ SFN | 63 | W 8-1 | 35-28 | 2 | 34,716 | Sean O'Sullivan | Jonathan Sanchez | Sean O'Sullivan | Jonathan Sanchez | | 313 | 306 | 7 |
| 2009-06-17 | @ SFN | 64 | W 4-3 | 36-28 | 2 | 37,431 | Matt Palmer | Tim Lincecum | Kevin Jepsen | Tim Lincecum | Brian Fuentes | 317 | 309 | 8 |
| 2009-06-19 | vs LAN | 65 | W 5-4 | 37-28 | 2 | 44,222 | Joe Saunders | Chad Billingsley | Justin Speier | Guillermo Mota | Brian Fuentes | 322 | 313 | 9 |
| 2009-06-20 | vs LAN | 66 | L 4-6 | 37-29 | 2 | 44,148 | Jered Weaver | Jeff Weaver | Jeff Weaver | Jered Weaver | | 326 | 319 | 7 |
| 2009-06-21 | vs LAN | 67 | L 3-5 | 37-30 | 2 | 43,891 | John Lackey | Clayton Kershaw | Clayton Kershaw | John Lackey | Jonathan Broxton | 329 | 324 | 5 |
| 2009-06-22 | vs COL | 68 | L 1-11 | 37-31 | 2 | 39,557 | Matt Palmer | Aaron Cook | Aaron Cook | Matt Palmer | | 330 | 335 | -5 |
| 2009-06-23 | vs COL | 69 | W 4-3 | 38-31 | 1 | 42,233 | Sean O'Sullivan | Ubaldo Jimenez | Kevin Jepsen | Ubaldo Jimenez | Brian Fuentes | 334 | 338 | -4 |
| 2009-06-24 | vs COL | 70 | W 11-3 | 38-32 | 2 | 43,551 | Joe Saunders | Jason Marquis | Joe Saunders | Jason Marquis | | 345 | 341 | 4 |
| 2009-06-26 | @ ARI | 71 | W 12-3 | 38-33 | 2 | 24,870 | Jered Weaver | Billy Buckner | Jered Weaver | Billy Buckner | | 357 | 344 | 13 |
| 2009-06-27 | @ ARI | 72 | W 2-1 | 39-33 | 2 | 27,742 | John Lackey | Doug Davis | Darren Oliver | Chad Qualls | Brian Fuentes | 359 | 345 | 14 |
| 2009-06-28 | @ ARI | 73 | W 12-8 | 39-34 | 2 | 25,684 | Matt Palmer | Max Scherzer | Matt Palmer | Max Scherzer | | 371 | 353 | 18 |
| 2009-06-29 | @ TEX | 74 | W 5-2 | 40-34 | 1 | 16,985 | Sean O'Sullivan | Vicente Padilla | Sean O'Sullivan | Vicente Padilla | Brian Fuentes | 376 | 355 | 21 |
| 2009-06-30 | @ TEX | 75 | L 5-9 | 40-35 | 2 | 20,042 | Joe Saunders | Scott Feldman | Scott Feldman | Joe Saunders | | 381 | 364 | 17 |
| 2009-07-01 | @ TEX | 76 | L 7-9 | 40-36 | 2 | 27,142 | Jered Weaver | Kevin Millwood | Frank Francisco | Justin Speier | | 388 | 373 | 15 |
| 2009-07-02 | vs BAL | 77 | W 5-2 | 41-36 | 2 | 39,180 | John Lackey | Jeremy Guthrie | John Lackey | Jeremy Guthrie | Brian Fuentes | 393 | 375 | 18 |
| 2009-07-03 | vs BAL | 78 | L 4-6 | 41-37 | 2 | 39,104 | Ervin Santana | David Hernandez | David Hernandez | Ervin Santana | George Sherrill | 397 | 381 | 16 |
| 2009-07-04 | vs BAL | 79 | W 11-4 | 41-38 | 3 | 41,764 | Sean O'Sullivan | Jason Berken | Jason Bulger | Danys Baez | | 408 | 385 | 23 |
| 2009-07-05 | vs BAL | 80 | W 9-6 | 42-38 | 2 | 35,912 | Joe Saunders | Rich Hill | Darren Oliver | Matt Albers | Brian Fuentes | 417 | 391 | 26 |
| 2009-07-06 | vs TEX | 81 | W 9-4 | 43-38 | 2 | 35,691 | Jered Weaver | Kevin Millwood | Jered Weaver | Kevin Millwood | | 426 | 395 | 31 |
| 2009-07-07 | vs TEX | 82 | L 5-8 | 43-39 | 3 | 42,088 | John Lackey | Dustin Nippert | Derek Holland | John Lackey | | 431 | 403 | 28 |
| 2009-07-08 | vs TEX | 83 | L 1-8 | 43-40 | 3 | 37,364 | Ervin Santana | Vicente Padilla | Vicente Padilla | Ervin Santana | | 432 | 411 | 21 |
| 2009-07-10 | vs NYA | 84 | W 10-6 | 43-41 | 3 | 44,076 | Joe Saunders | Joba Chamberlain | Jason Bulger | Mark Melancon | Brian Fuentes | 442 | 417 | 25 |
| 2009-07-11 | vs NYA | 85 | W 14-8 | 43-42 | 3 | 42,602 | Jered Weaver | Andy Pettitte | Jered Weaver | Andy Pettitte | | 456 | 425 | 31 |
| 2009-07-12 | vs NYA | 86 | W 5-4 | 44-42 | 3 | 41,532 | John Lackey | CC Sabathia | John Lackey | CC Sabathia | Brian Fuentes | 461 | 429 | 32 |
| 2009-07-16 | @ OAK | 87 | W 6-2 | 45-42 | 3 | 11,113 | Ervin Santana | Dallas Braden | Ervin Santana | Dallas Braden | Brian Fuentes | 467 | 431 | 36 |
| 2009-07-17 | @ OAK | 88 | L 3-7 | 45-43 | 3 | 17,147 | Joe Saunders | Trevor Cahill | Craig Breslow | Joe Saunders | | 470 | 438 | 32 |
| 2009-07-18 | @ OAK | 89 | W 11-6 | 45-44 | 3 | 16,475 | Jered Weaver | Vin Mazzaro | Darren Oliver | Vin Mazzaro | | 481 | 444 | 37 |
| 2009-07-19 | @ OAK | 90 | W 1-0 | 46-44 | 3 | 18,539 | John Lackey | Brett Anderson | John Lackey | Andrew Bailey | Brian Fuentes | 482 | 444 | 38 |
| 2009-07-21 | @ KCA | 91 | W 8-5 | 47-45 | 4 | 0 | Ervin Santana | Sidney Ponson | Ervin Santana | Sidney Ponson | Brian Fuentes | 490 | 449 | 41 |
| 2009-07-21 | @ KCA | 92 | W 10-2 | 47-45 | 4 | 23,874 | Sean O'Sullivan | Bruce Chen | Sean O'Sullivan | Bruce Chen | | 500 | 451 | 49 |
| 2009-07-22 | @ KCA | 93 | W 9-6 | 48-45 | 3 | 18,078 | Joe Saunders | Brian Bannister | Justin Speier | Roman Colon | Brian Fuentes | 509 | 457 | 52 |
| 2009-07-23 | vs MIN | 94 | W 6-5 | 49-45 | 3 | 38,145 | Jered Weaver | Scott Baker | Brian Fuentes | Jesse Crain | | 515 | 462 | 53 |
| 2009-07-24 | vs MIN | 95 | W 6-3 | 50-45 | 3 | 39,272 | John Lackey | Francisco Liriano | John Lackey | Francisco Liriano | | 521 | 465 | 56 |
| 2009-07-25 | vs MIN | 96 | W 11-5 | 50-46 | 3 | 35,922 | Matt Palmer | Nick Blackburn | Matt Palmer | Nick Blackburn | | 532 | 470 | 62 |
| 2009-07-26 | vs MIN | 97 | L 1-10 | 50-47 | 3 | 36,386 | Ervin Santana | Anthony Swarzak | Anthony Swarzak | Ervin Santana | | 533 | 480 | 53 |
| 2009-07-27 | vs CLE | 98 | L 6-8 | 50-48 | 3 | 35,371 | Joe Saunders | Carl Pavano | Jose Veras | Brian Fuentes | Kerry Wood | 539 | 488 | 51 |
| 2009-07-28 | vs CLE | 99 | W 7-6 | 51-48 | 3 | 43,270 | Jered Weaver | David Huff | Matt Palmer | David Huff | Jason Bulger | 546 | 494 | 52 |
| 2009-07-29 | vs CLE | 100 | W 9-3 | 52-48 | 3 | 39,196 | John Lackey | Aaron Laffey | John Lackey | Aaron Laffey | | 555 | 497 | 58 |
| 2009-07-31 | @ MIN | 101 | W 11-5 | 52-49 | 3 | 31,767 | Ervin Santana | Nick Blackburn | Kevin Jepsen | Bobby Keppel | | 566 | 502 | 64 |
| 2009-08-01 | @ MIN | 102 | W 11-6 | 52-50 | 3 | 40,828 | Joe Saunders | Anthony Swarzak | Joe Saunders | Anthony Swarzak | | 577 | 508 | 69 |
| 2009-08-02 | @ MIN | 103 | W 13-4 | 52-51 | 3 | 41,079 | Jered Weaver | Glen Perkins | Jered Weaver | Glen Perkins | | 590 | 512 | 78 |
| 2009-08-04 | @ CHA | 104 | L 4-5 | 52-52 | 3 | 30,228 | John Lackey | Jose Contreras | Matt Thornton | Kevin Jepsen | | 594 | 517 | 77 |
| 2009-08-05 | @ CHA | 105 | L 2-6 | 52-53 | 3 | 32,167 | Sean O'Sullivan | Gavin Floyd | Gavin Floyd | Sean O'Sullivan | | 596 | 523 | 73 |
| 2009-08-06 | @ CHA | 106 | W 9-5 | 53-53 | 3 | 27,487 | Ervin Santana | John Danks | Ervin Santana | John Danks | | 605 | 528 | 77 |
| 2009-08-07 | vs TEX | 107 | L 6-11 | 54-53 | 3 | 43,624 | Joe Saunders | Scott Feldman | Scott Feldman | Joe Saunders | | 611 | 539 | 72 |
| 2009-08-08 | vs TEX | 108 | W 3-2 | 55-53 | 3 | 37,166 | Jered Weaver | Kevin Millwood | Jered Weaver | Eddie Guardado | Brian Fuentes | 614 | 541 | 73 |
| 2009-08-09 | vs TEX | 109 | L 0-7 | 55-54 | 3 | 35,706 | John Lackey | Derek Holland | Derek Holland | John Lackey | | 614 | 548 | 66 |
| 2009-08-10 | vs TBA | 110 | W 8-7 | 56-54 | 3 | 37,388 | Sean O'Sullivan | Matt Garza | Kevin Jepsen | Russ Springer | Brian Fuentes | 622 | 555 | 67 |
| 2009-08-11 | vs TBA | 111 | W 6-0 | 57-54 | 3 | 43,559 | Ervin Santana | David Price | Ervin Santana | David Price | | 628 | 555 | 73 |
| 2009-08-12 | vs TBA | 112 | W 10-5 | 57-55 | 3 | 37,859 | Trevor Bell | Jeff Niemann | Jason Bulger | Grant Balfour | | 638 | 560 | 78 |
| 2009-08-14 | @ BAL | 113 | L 6-16 | 58-55 | 3 | 25,836 | Jered Weaver | Chris Tillman | Chris Tillman | Jered Weaver | | 644 | 576 | 68 |
| 2009-08-15 | @ BAL | 114 | W 5-1 | 59-55 | 3 | 28,770 | John Lackey | Brian Matusz | John Lackey | Brian Matusz | Brian Fuentes | 649 | 577 | 72 |
| 2009-08-16 | @ BAL | 115 | W 17-8 | 59-56 | 3 | 26,529 | Sean O'Sullivan | Jeremy Guthrie | Jason Bulger | Brian Bass | | 666 | 585 | 81 |
| 2009-08-17 | @ BAL | 116 | W 8-5 | 60-56 | 3 | 18,460 | Ervin Santana | David Hernandez | Ervin Santana | David Hernandez | Brian Fuentes | 674 | 590 | 84 |
| 2009-08-18 | @ CLE | 117 | W 5-4 | 61-56 | 3 | 18,341 | Trevor Bell | Fausto Carmona | Trevor Bell | Fausto Carmona | Brian Fuentes | 679 | 594 | 85 |
| 2009-08-19 | @ CLE | 118 | W 3-0 | 62-56 | 3 | 16,868 | Jered Weaver | Jeremy Sowers | Jered Weaver | Jeremy Sowers | | 682 | 594 | 88 |
| 2009-08-20 | @ CLE | 119 | L 3-11 | 63-56 | 2 | 16,804 | John Lackey | Justin Masterson | Justin Masterson | John Lackey | | 685 | 605 | 80 |
| 2009-08-21 | @ TOR | 120 | L 4-5 | 63-57 | 3 | 15,993 | Sean O'Sullivan | Marc Rzepczynski | Marc Rzepczynski | Sean O'Sullivan | Casey Janssen | 689 | 610 | 79 |
| 2009-08-22 | @ TOR | 121 | W 7-3 | 64-57 | 2 | 23,235 | Ervin Santana | Scott Richmond | Ervin Santana | Scott Richmond | | 696 | 613 | 83 |
| 2009-08-23 | @ TOR | 122 | L 3-8 | 64-58 | 2 | 23,935 | Trevor Bell | Ricky Romero | Ricky Romero | Trevor Bell | | 699 | 621 | 78 |
| 2009-08-24 | vs DET | 123 | L 7-10 | 65-58 | 2 | 38,421 | Jered Weaver | Justin Verlander | Justin Verlander | Jered Weaver | Fernando Rodney | 706 | 631 | 75 |
| 2009-08-25 | vs DET | 124 | L 3-5 | 65-59 | 3 | 42,970 | John Lackey | Jarrod Washburn | Jarrod Washburn | John Lackey | Fernando Rodney | 709 | 636 | 73 |
| 2009-08-26 | vs DET | 125 | W 4-2 | 66-59 | 3 | 36,329 | Joe Saunders | Edwin Jackson | Joe Saunders | Edwin Jackson | Brian Fuentes | 713 | 638 | 75 |
| 2009-08-27 | vs OAK | 126 | L 0-2 | 66-60 | 3 | 43,139 | Ervin Santana | Trevor Cahill | Trevor Cahill | Ervin Santana | Andrew Bailey | 713 | 640 | 73 |
| 2009-08-28 | vs OAK | 127 | W 11-7 | 66-61 | 3 | 41,912 | Trevor Bell | Brett Tomko | Jose Arredondo | Brad Ziegler | Brian Fuentes | 724 | 647 | 77 |
| 2009-08-29 | vs OAK | 128 | L 3-4 | 66-62 | 3 | 43,011 | Jered Weaver | Vin Mazzaro | Brad Ziegler | Rafael Rodriguez | Andrew Bailey | 727 | 651 | 76 |
| 2009-08-30 | vs OAK | 129 | W 9-1 | 67-62 | 3 | 38,018 | John Lackey | Brett Anderson | John Lackey | Brett Anderson | | 736 | 652 | 84 |
| 2009-08-31 | @ SEA | 130 | W 10-0 | 68-62 | 3 | 18,959 | Joe Saunders | Lucas French | Joe Saunders | Lucas French | | 746 | 652 | 94 |
| 2009-09-01 | @ SEA | 131 | L 1-2 | 68-63 | 4 | 18,542 | Ervin Santana | Doug Fister | Doug Fister | Darren Oliver | David Aardsma | 747 | 654 | 93 |
| 2009-09-02 | @ SEA | 132 | L 0-3 | 68-64 | 3 | 22,130 | Scott Kazmir | Felix Hernandez | Felix Hernandez | Scott Kazmir | David Aardsma | 747 | 657 | 90 |
| 2009-09-04 | @ KCA | 133 | W 2-1 | 69-64 | 3 | 17,447 | Jered Weaver | Rob Tejeda | Jered Weaver | Jamey Wright | Brian Fuentes | 749 | 658 | 91 |
| 2009-09-05 | @ KCA | 134 | W 2-1 | 70-64 | 3 | 22,628 | John Lackey | Zack Greinke | Kevin Jepsen | Yasuhiko Yabuta | Brian Fuentes | 751 | 659 | 92 |
| 2009-09-06 | @ KCA | 135 | W 7-2 | 71-64 | 3 | 16,745 | Joe Saunders | Luke Hochevar | Joe Saunders | Luke Hochevar | | 758 | 661 | 97 |
| 2009-09-07 | @ KCA | 136 | L 3-6 | 71-65 | 3 | 18,453 | Ervin Santana | Kyle Davies | Kyle Davies | Ervin Santana | Joakim Soria | 761 | 667 | 94 |
| 2009-09-08 | vs SEA | 137 | W 3-2 | 72-65 | 4 | 37,725 | Scott Kazmir | Felix Hernandez | Matt Palmer | Miguel Batista | | 764 | 669 | 95 |
| 2009-09-09 | vs SEA | 138 | W 6-3 | 73-65 | 2 | 36,340 | Jered Weaver | Ian Snell | Jered Weaver | Ian Snell | Brian Fuentes | 770 | 672 | 98 |
| 2009-09-10 | vs SEA | 139 | W 3-0 | 74-65 | 2 | 37,412 | John Lackey | Ryan Rowland-Smith | John Lackey | Ryan Rowland-Smith | | 773 | 672 | 101 |
| 2009-09-11 | vs CHA | 140 | W 7-1 | 75-65 | 2 | 38,375 | Joe Saunders | Gavin Floyd | Joe Saunders | Gavin Floyd | | 780 | 673 | 107 |
| 2009-09-12 | vs CHA | 141 | L 3-4 | 75-66 | 2 | 37,390 | Ervin Santana | John Danks | Bobby Jenks | Brian Fuentes | Tony Pena | 783 | 677 | 106 |
| 2009-09-13 | vs CHA | 142 | W 3-2 | 76-66 | 2 | 37,512 | Scott Kazmir | Mark Buehrle | Darren Oliver | Mark Buehrle | Brian Fuentes | 786 | 679 | 107 |
| 2009-09-14 | @ NYA | 143 | L 3-5 | 76-67 | 1 | 44,701 | Jered Weaver | Joba Chamberlain | Phil Hughes | Jered Weaver | Mariano Rivera | 789 | 684 | 105 |
| 2009-09-15 | @ BOS | 144 | L 1-4 | 76-68 | 1 | 37,942 | John Lackey | Daisuke Matsuzaka | Daisuke Matsuzaka | John Lackey | | 790 | 688 | 102 |
| 2009-09-16 | @ BOS | 145 | L 8-9 | 76-69 | 2 | 37,706 | Joe Saunders | Paul Byrd | Daniel Bard | Brian Fuentes | | 798 | 697 | 101 |
| 2009-09-17 | @ BOS | 146 | W 4-3 | 77-69 | 2 | 38,157 | Ervin Santana | Josh Beckett | Kevin Jepsen | Billy Wagner | Brian Fuentes | 802 | 700 | 102 |
| 2009-09-18 | @ TEX | 147 | W 2-0 | 78-69 | 2 | 34,240 | Scott Kazmir | Tommy Hunter | Scott Kazmir | Tommy Hunter | Brian Fuentes | 804 | 700 | 104 |
| 2009-09-19 | @ TEX | 148 | L 2-3 | 78-70 | 2 | 46,596 | Jered Weaver | Scott Feldman | Scott Feldman | Jered Weaver | Frank Francisco | 806 | 703 | 103 |
| 2009-09-20 | @ TEX | 149 | W 10-5 | 78-71 | 3 | 33,688 | John Lackey | Derek Holland | John Lackey | Derek Holland | | 816 | 708 | 108 |
| 2009-09-21 | vs NYA | 150 | W 5-2 | 79-71 | 2 | 38,667 | Joe Saunders | Andy Pettitte | Joe Saunders | Andy Pettitte | Brian Fuentes | 821 | 710 | 111 |
| 2009-09-22 | vs NYA | 151 | L 5-6 | 79-72 | 2 | 40,374 | Ervin Santana | Chad Gaudin | Phil Hughes | Matt Palmer | Mariano Rivera | 826 | 716 | 110 |
| 2009-09-23 | vs NYA | 152 | L 2-3 | 79-73 | 3 | 35,760 | Scott Kazmir | A.J. Burnett | A.J. Burnett | Scott Kazmir | Mariano Rivera | 828 | 719 | 109 |
| 2009-09-25 | vs OAK | 153 | L 0-3 | 79-74 | 3 | 43,242 | Jered Weaver | Gio Gonzalez | Gio Gonzalez | Jered Weaver | Andrew Bailey | 828 | 722 | 106 |
| 2009-09-26 | vs OAK | 154 | L 10-15 | 79-75 | 3 | 41,014 | John Lackey | Dana Eveland | Craig Breslow | Kevin Jepsen | | 838 | 737 | 101 |
| 2009-09-27 | vs OAK | 155 | W 7-4 | 80-75 | 3 | 38,718 | Joe Saunders | Edgar Gonzalez | Joe Saunders | Edgar Gonzalez | Brian Fuentes | 845 | 741 | 104 |
| 2009-09-28 | vs TEX | 156 | W 11-0 | 81-75 | 2 | 40,484 | Ervin Santana | Tommy Hunter | Ervin Santana | Tommy Hunter | | 856 | 741 | 115 |
| 2009-09-29 | vs TEX | 157 | W 5-2 | 82-75 | 2 | 38,600 | Sean O'Sullivan | Scott Feldman | Sean O'Sullivan | Scott Feldman | Brian Fuentes | 861 | 743 | 118 |
| 2009-09-30 | vs TEX | 158 | W 5-0 | 83-75 | 2 | 40,616 | Matt Palmer | Derek Holland | Matt Palmer | Derek Holland | | 866 | 743 | 123 |
| 2009-10-01 | vs TEX | 159 | L 3-11 | 84-75 | 2 | 38,552 | John Lackey | Kevin Millwood | Kevin Millwood | Trevor Bell | | 869 | 754 | 115 |
| 2009-10-02 | @ OAK | 160 | W 5-2 | 85-75 | 1 | 14,554 | Jered Weaver | Gio Gonzalez | Jered Weaver | Gio Gonzalez | Brian Fuentes | 874 | 756 | 118 |
| 2009-10-03 | @ OAK | 161 | W 4-2 | 86-75 | 1 | 16,539 | Scott Kazmir | Dana Eveland | Scott Kazmir | Dana Eveland | Brian Fuentes | 878 | 758 | 120 |
| 2009-10-04 | @ OAK | 162 | W 5-3 | 87-75 | 1 | 16,591 | Joe Saunders | Brad Kilby | Joe Saunders | Jeff Gray | Kevin Jepsen | 883 | 761 | 122 |