| 2008-03-30 | @ WAS | 1 | L 2-3 | 0-1 | 2 | 39,389 | Tim Hudson | Odalis Perez | Jon Rauch | Peter Moylan | | 2 | 3 | -1 |
| 2008-03-31 | vs PIT | 2 | L 11-12 | 0-2 | 3 | 45,269 | Tom Glavine | Ian Snell | Franquelis Osoria | Blaine Boyer | | 13 | 15 | -2 |
| 2008-04-02 | vs PIT | 3 | W 10-2 | 1-2 | 3 | 17,893 | Jair Jurrjens | Tom Gorzelanny | Jair Jurrjens | Tom Gorzelanny | | 23 | 17 | 6 |
| 2008-04-03 | vs PIT | 4 | L 3-4 | 1-3 | 5 | 19,240 | Jeff Bennett | Zach Duke | Tyler Yates | Chris Resop | Matt Capps | 26 | 21 | 5 |
| 2008-04-05 | vs NYN | 5 | W 11-5 | 2-3 | 4 | 36,130 | Tim Hudson | John Maine | Tim Hudson | John Maine | | 37 | 26 | 11 |
| 2008-04-06 | vs NYN | 6 | W 3-1 | 3-3 | 1 | 39,414 | John Smoltz | Johan Santana | John Smoltz | Johan Santana | Rafael Soriano | 40 | 27 | 13 |
| 2008-04-07 | @ COL | 7 | L 1-2 | 3-4 | 2 | 24,304 | Tom Glavine | Aaron Cook | Matt Herges | Blaine Boyer | Manuel Corpas | 41 | 29 | 12 |
| 2008-04-08 | @ COL | 8 | L 3-4 | 3-5 | 3 | 24,640 | Jair Jurrjens | Ubaldo Jimenez | Ubaldo Jimenez | Jair Jurrjens | Manuel Corpas | 44 | 33 | 11 |
| 2008-04-09 | @ COL | 9 | L 6-12 | 3-6 | 4 | 23,210 | Chuck James | Mark Redman | Mark Redman | Chuck James | | 50 | 45 | 5 |
| 2008-04-11 | @ WAS | 10 | W 3-0 | 4-6 | 4 | 28,051 | Tim Hudson | Matt Chico | Tim Hudson | Matt Chico | Peter Moylan | 53 | 45 | 8 |
| 2008-04-12 | @ WAS | 11 | W 10-2 | 5-6 | 4 | 32,532 | John Smoltz | John Lannan | John Smoltz | John Lannan | | 63 | 47 | 16 |
| 2008-04-13 | @ WAS | 12 | L 4-5 | 5-7 | 4 | 29,151 | Tom Glavine | Tim Redding | Tim Redding | Tom Glavine | Jon Rauch | 67 | 52 | 15 |
| 2008-04-15 | @ FLO | 13 | L 0-4 | 5-8 | 4 | 10,462 | Jair Jurrjens | Scott Olsen | Scott Olsen | Jair Jurrjens | | 67 | 56 | 11 |
| 2008-04-16 | @ FLO | 14 | L 5-6 | 5-9 | 4 | 10,712 | Tim Hudson | Mark Hendrickson | Mark Hendrickson | Tim Hudson | Kevin Gregg | 72 | 62 | 10 |
| 2008-04-17 | @ FLO | 15 | W 8-0 | 6-9 | 4 | 11,237 | John Smoltz | Ricky Nolasco | John Smoltz | Ricky Nolasco | | 80 | 62 | 18 |
| 2008-04-18 | vs LAN | 16 | W 6-1 | 7-9 | 4 | 38,250 | Jeff Bennett | Derek Lowe | Will Ohman | Derek Lowe | | 86 | 63 | 23 |
| 2008-04-19 | vs LAN | 17 | W 4-1 | 8-9 | 3 | 40,451 | Chuck James | Chad Billingsley | Chuck James | Chad Billingsley | Manny Acosta | 90 | 64 | 26 |
| 2008-04-20 | vs LAN | 18 | W 6-1 | 9-9 | 3 | 36,772 | Jair Jurrjens | Hiroki Kuroda | Jair Jurrjens | Hiroki Kuroda | | 96 | 65 | 31 |
| 2008-04-21 | vs WAS | 19 | W 7-3 | 10-9 | 3 | 16,706 | Tim Hudson | Matt Chico | Tim Hudson | Matt Chico | | 103 | 68 | 35 |
| 2008-04-22 | vs WAS | 20 | L 0-6 | 10-10 | 4 | 23,482 | John Smoltz | John Lannan | John Lannan | John Smoltz | | 103 | 74 | 29 |
| 2008-04-23 | vs FLO | 21 | L 2-7 | 10-11 | 4 | 19,852 | Jeff Bennett | Andrew Miller | Andrew Miller | Jeff Bennett | | 105 | 81 | 24 |
| 2008-04-24 | vs FLO | 22 | W 7-4 | 11-11 | 4 | 19,903 | Chuck James | Burke Badenhop | Chuck James | Burke Badenhop | Manny Acosta | 112 | 85 | 27 |
| 2008-04-25 | @ NYN | 23 | W 6-3 | 12-11 | 3 | 52,495 | Jair Jurrjens | Mike Pelfrey | Jair Jurrjens | Mike Pelfrey | | 118 | 88 | 30 |
| 2008-04-26 | @ NYN | 24 | L 3-4 | 12-12 | 4 | 51,339 | Tim Hudson | John Maine | John Maine | Tim Hudson | Billy Wagner | 121 | 92 | 29 |
| 2008-04-27 | @ NYN | 25 | L 3-6 | 12-13 | 4 | 53,487 | John Smoltz | Nelson Figueroa | Nelson Figueroa | John Smoltz | Billy Wagner | 124 | 98 | 26 |
| 2008-04-29 | @ WAS | 26 | L 3-6 | 12-14 | 4 | 25,285 | Tom Glavine | Tim Redding | Saul Rivera | Blaine Boyer | Jon Rauch | 127 | 104 | 23 |
| 2008-04-30 | @ WAS | 27 | L 2-3 | 12-15 | 4 | 29,473 | Jair Jurrjens | Shawn Hill | Saul Rivera | Manny Acosta | | 129 | 107 | 22 |
| 2008-05-02 | vs CIN | 28 | W 2-0 | 13-15 | 4 | 32,057 | Tim Hudson | Edinson Volquez | Tim Hudson | Edinson Volquez | | 131 | 107 | 24 |
| 2008-05-03 | vs CIN | 29 | W 9-1 | 14-15 | 4 | 37,969 | Jo-Jo Reyes | Matt Belisle | Jo-Jo Reyes | Matt Belisle | | 140 | 108 | 32 |
| 2008-05-04 | vs CIN | 30 | W 14-7 | 15-15 | 4 | 33,750 | Tom Glavine | Bronson Arroyo | Royce Ring | Bronson Arroyo | | 154 | 115 | 39 |
| 2008-05-06 | vs SDN | 31 | W 5-3 | 16-15 | 3 | 21,657 | Jair Jurrjens | Chris Young | Jair Jurrjens | Chris Young | Jeff Bennett | 159 | 118 | 41 |
| 2008-05-07 | vs SDN | 32 | W 5-2 | 17-15 | 3 | 25,194 | Tim Hudson | Randy Wolf | Tim Hudson | Randy Wolf | | 164 | 120 | 44 |
| 2008-05-08 | vs SDN | 33 | W 5-4 | 18-15 | 3 | 28,337 | Jo-Jo Reyes | Wil Ledezma | Manny Acosta | Joe Thatcher | | 169 | 124 | 45 |
| 2008-05-09 | @ PIT | 34 | L 2-3 | 18-16 | 4 | 21,050 | Tom Glavine | Ian Snell | John Grabow | Jeff Bennett | | 171 | 127 | 44 |
| 2008-05-10 | @ PIT | 35 | L 2-5 | 18-17 | 4 | 28,141 | Chuck James | Tom Gorzelanny | Tom Gorzelanny | Chuck James | Matt Capps | 173 | 132 | 41 |
| 2008-05-12 | @ PIT | 36 | L 0-5 | 19-18 | 4 | 0 | Jair Jurrjens | Zach Duke | Zach Duke | Jair Jurrjens | | 173 | 137 | 36 |
| 2008-05-12 | @ PIT | 37 | W 8-1 | 19-18 | 4 | 16,669 | Tim Hudson | John Van Benschoten | Tim Hudson | John Van Benschoten | | 181 | 138 | 43 |
| 2008-05-13 | @ PHI | 38 | L 4-5 | 19-19 | 4 | 44,101 | Jo-Jo Reyes | Kyle Kendrick | Kyle Kendrick | Jo-Jo Reyes | Brad Lidge | 185 | 143 | 42 |
| 2008-05-14 | @ PHI | 39 | W 8-6 | 20-19 | 4 | 36,001 | Tom Glavine | Brett Myers | Tom Glavine | Brett Myers | Blaine Boyer | 193 | 149 | 44 |
| 2008-05-15 | @ PHI | 40 | L 0-5 | 20-20 | 4 | 34,120 | Chuck James | Cole Hamels | Cole Hamels | Chuck James | | 193 | 154 | 39 |
| 2008-05-16 | vs OAK | 41 | W 3-2 | 21-20 | 4 | 31,004 | Jair Jurrjens | Dana Eveland | Manny Acosta | Alan Embree | | 196 | 156 | 40 |
| 2008-05-17 | vs OAK | 42 | L 4-5 | 21-21 | 4 | 38,324 | Tim Hudson | Rich Harden | Rich Harden | Tim Hudson | | 200 | 161 | 39 |
| 2008-05-18 | vs OAK | 43 | W 5-2 | 22-21 | 4 | 31,025 | Jo-Jo Reyes | Justin Duchscherer | Jo-Jo Reyes | Justin Duchscherer | | 205 | 163 | 42 |
| 2008-05-20 | vs NYN | 44 | W 6-1 | 24-21 | 2 | 26,873 | Tom Glavine | John Maine | Tom Glavine | John Maine | | 211 | 164 | 47 |
| 2008-05-20 | vs NYN | 45 | W 6-2 | 24-21 | 2 | 25,590 | Jorge Campillo | Claudio Vargas | Jorge Campillo | Claudio Vargas | Manny Acosta | 217 | 166 | 51 |
| 2008-05-21 | vs NYN | 46 | W 11-4 | 25-21 | 2 | 30,335 | Jair Jurrjens | Mike Pelfrey | Jair Jurrjens | Mike Pelfrey | | 228 | 170 | 58 |
| 2008-05-22 | vs NYN | 47 | W 4-2 | 26-21 | 2 | 30,348 | Tim Hudson | Johan Santana | Tim Hudson | Johan Santana | Will Ohman | 232 | 172 | 60 |
| 2008-05-23 | vs ARI | 48 | L 1-11 | 26-22 | 2 | 27,263 | Jo-Jo Reyes | Doug Davis | Doug Davis | Jo-Jo Reyes | | 233 | 183 | 50 |
| 2008-05-24 | vs ARI | 49 | W 3-1 | 27-22 | 2 | 36,263 | Jorge Campillo | Randy Johnson | Blaine Boyer | Doug Slaten | | 236 | 184 | 52 |
| 2008-05-25 | vs ARI | 50 | L 3-9 | 27-23 | 2 | 35,628 | Tom Glavine | Micah Owings | Micah Owings | Tom Glavine | | 239 | 193 | 46 |
| 2008-05-26 | vs ARI | 51 | W 7-3 | 28-23 | 2 | 29,635 | Jair Jurrjens | Brandon Webb | Manny Acosta | Brandon Webb | | 246 | 196 | 50 |
| 2008-05-27 | @ MIL | 52 | L 2-3 | 28-24 | 3 | 28,872 | Tim Hudson | David Bush | Salomon Torres | Jeff Bennett | | 248 | 199 | 49 |
| 2008-05-28 | @ MIL | 53 | L 0-1 | 28-25 | 3 | 31,612 | Jo-Jo Reyes | Jeff Suppan | Jeff Suppan | Jo-Jo Reyes | Salomon Torres | 248 | 200 | 48 |
| 2008-05-29 | @ MIL | 54 | W 8-1 | 29-25 | 3 | 33,334 | Jorge Campillo | Seth McClung | Jorge Campillo | Seth McClung | | 256 | 201 | 55 |
| 2008-05-30 | @ CIN | 55 | L 2-3 | 29-26 | 3 | 37,015 | Tom Glavine | Edinson Volquez | Kent Mercker | Royce Ring | | 258 | 204 | 54 |
| 2008-05-31 | @ CIN | 56 | L 7-8 | 29-27 | 3 | 38,585 | Jair Jurrjens | Josh Fogg | Francisco Cordero | Manny Acosta | | 265 | 212 | 53 |
| 2008-06-01 | @ CIN | 57 | L 2-6 | 29-28 | 4 | 35,942 | Tim Hudson | Johnny Cueto | Johnny Cueto | Tim Hudson | | 267 | 218 | 49 |
| 2008-06-02 | vs FLO | 58 | W 7-5 | 30-28 | 3 | 20,896 | Jo-Jo Reyes | Scott Olsen | Will Ohman | Logan Kensing | | 274 | 223 | 51 |
| 2008-06-03 | vs FLO | 59 | W 5-4 | 31-28 | 3 | 25,476 | Jorge Campillo | Burke Badenhop | Will Ohman | Matt Lindstrom | Rafael Soriano | 279 | 227 | 52 |
| 2008-06-04 | vs FLO | 60 | L 4-6 | 31-29 | 4 | 26,917 | Tom Glavine | Mark Hendrickson | Justin Miller | Manny Acosta | Kevin Gregg | 283 | 233 | 50 |
| 2008-06-05 | vs FLO | 61 | W 7-5 | 32-29 | 3 | 27,238 | Jair Jurrjens | Ricky Nolasco | Jair Jurrjens | Ricky Nolasco | Rafael Soriano | 290 | 238 | 52 |
| 2008-06-06 | vs PHI | 62 | L 3-4 | 32-30 | 3 | 34,074 | Tim Hudson | Jamie Moyer | Tom Gordon | Manny Acosta | Brad Lidge | 293 | 242 | 51 |
| 2008-06-07 | vs PHI | 63 | L 2-6 | 32-31 | 3 | 43,854 | Jo-Jo Reyes | Kyle Kendrick | J.C. Romero | Jo-Jo Reyes | | 295 | 248 | 47 |
| 2008-06-08 | vs PHI | 64 | L 3-6 | 32-32 | 3 | 33,370 | Jorge Campillo | Adam Eaton | Chad Durbin | Blaine Boyer | Brad Lidge | 298 | 254 | 44 |
| 2008-06-10 | @ CHN | 65 | L 5-10 | 32-33 | 3 | 41,624 | Tom Glavine | Ted Lilly | Ted Lilly | Tom Glavine | | 303 | 264 | 39 |
| 2008-06-11 | @ CHN | 66 | L 2-7 | 32-34 | 3 | 41,497 | Jeff Bennett | Ryan Dempster | Ryan Dempster | Jeff Bennett | | 305 | 271 | 34 |
| 2008-06-12 | @ CHN | 67 | L 2-3 | 32-35 | 3 | 41,517 | Tim Hudson | Carlos Zambrano | Kerry Wood | Manny Acosta | | 307 | 274 | 33 |
| 2008-06-13 | @ ANA | 68 | W 5-2 | 33-35 | 3 | 43,919 | Jo-Jo Reyes | Jon Garland | Jo-Jo Reyes | Jon Garland | Jeff Bennett | 312 | 276 | 36 |
| 2008-06-14 | @ ANA | 69 | W 9-4 | 34-35 | 3 | 43,894 | Charlie Morton | Ervin Santana | Charlie Morton | Ervin Santana | | 321 | 280 | 41 |
| 2008-06-15 | @ ANA | 70 | L 0-2 | 34-36 | 3 | 43,723 | Jorge Campillo | Joe Saunders | Joe Saunders | Jorge Campillo | Francisco Rodriguez | 321 | 282 | 39 |
| 2008-06-16 | @ COL | 71 | W 7-1 | 35-36 | 3 | 25,120 | Jair Jurrjens | Ubaldo Jimenez | Jair Jurrjens | Ubaldo Jimenez | | 328 | 283 | 45 |
| 2008-06-17 | @ TEX | 72 | L 5-7 | 35-37 | 3 | 33,558 | Tim Hudson | Vicente Padilla | Vicente Padilla | Tim Hudson | C.J. Wilson | 333 | 290 | 43 |
| 2008-06-18 | @ TEX | 73 | W 5-2 | 36-37 | 3 | 38,545 | Jo-Jo Reyes | Eric Hurley | Jeff Bennett | C.J. Wilson | Mike Gonzalez | 338 | 292 | 46 |
| 2008-06-19 | @ TEX | 74 | L 4-5 | 36-38 | 4 | 28,853 | Charlie Morton | Scott Feldman | Jamey Wright | Blaine Boyer | | 342 | 297 | 45 |
| 2008-06-20 | vs SEA | 75 | L 2-10 | 36-39 | 4 | 40,268 | Jorge Campillo | Erik Bedard | Ryan Rowland-Smith | Jorge Campillo | | 344 | 307 | 37 |
| 2008-06-21 | vs SEA | 76 | W 5-4 | 37-39 | 4 | 47,158 | Jair Jurrjens | Jarrod Washburn | Blaine Boyer | Miguel Batista | | 349 | 311 | 38 |
| 2008-06-22 | vs SEA | 77 | W 8-3 | 38-39 | 4 | 30,965 | Tim Hudson | Carlos Silva | Tim Hudson | Carlos Silva | | 357 | 314 | 43 |
| 2008-06-23 | vs MIL | 78 | L 1-4 | 38-40 | 4 | 25,661 | Jo-Jo Reyes | Ben Sheets | Ben Sheets | Jo-Jo Reyes | | 358 | 318 | 40 |
| 2008-06-24 | vs MIL | 79 | L 3-4 | 38-41 | 4 | 29,224 | Charlie Morton | David Bush | David Bush | Charlie Morton | Salomon Torres | 361 | 322 | 39 |
| 2008-06-25 | vs MIL | 80 | W 4-2 | 39-41 | 4 | 34,829 | Jorge Campillo | Jeff Suppan | Jorge Campillo | Jeff Suppan | Mike Gonzalez | 365 | 324 | 41 |
| 2008-06-27 | @ TOR | 81 | W 4-0 | 40-41 | 3 | 24,282 | Jair Jurrjens | Dustin McGowan | Jair Jurrjens | Dustin McGowan | | 369 | 324 | 45 |
| 2008-06-28 | @ TOR | 82 | L 5-9 | 40-42 | 3 | 28,518 | Tim Hudson | John Parrish | John Parrish | Tim Hudson | | 374 | 333 | 41 |
| 2008-06-29 | @ TOR | 83 | L 0-1 | 40-43 | 4 | 30,514 | Jo-Jo Reyes | A.J. Burnett | A.J. Burnett | Jo-Jo Reyes | B.J. Ryan | 374 | 334 | 40 |
| 2008-07-01 | vs PHI | 84 | L 3-8 | 40-44 | 4 | 29,206 | Charlie Morton | Kyle Kendrick | Kyle Kendrick | Charlie Morton | | 377 | 342 | 35 |
| 2008-07-02 | vs PHI | 85 | L 3-7 | 40-45 | 4 | 30,138 | Jorge Campillo | Adam Eaton | Adam Eaton | Jorge Campillo | | 380 | 349 | 31 |
| 2008-07-03 | vs PHI | 86 | L 1-4 | 40-46 | 4 | 28,805 | Jair Jurrjens | Cole Hamels | Cole Hamels | Jair Jurrjens | Tom Gordon | 381 | 353 | 28 |
| 2008-07-04 | vs HOU | 87 | W 6-2 | 41-46 | 4 | 48,045 | Tim Hudson | Brian Moehler | Tim Hudson | Brian Moehler | | 387 | 355 | 32 |
| 2008-07-05 | vs HOU | 88 | L 1-6 | 41-47 | 4 | 37,049 | Jo-Jo Reyes | Chris Sampson | Chris Sampson | Jo-Jo Reyes | | 388 | 361 | 27 |
| 2008-07-06 | vs HOU | 89 | W 7-6 | 42-47 | 4 | 24,169 | Charlie Morton | Wandy Rodriguez | Royce Ring | Tim Byrdak | | 395 | 367 | 28 |
| 2008-07-07 | @ LAN | 90 | L 0-3 | 42-48 | 4 | 39,896 | Jorge Campillo | Hiroki Kuroda | Hiroki Kuroda | Jorge Campillo | | 395 | 370 | 25 |
| 2008-07-08 | @ LAN | 91 | W 9-3 | 43-48 | 4 | 39,702 | Jair Jurrjens | Chad Billingsley | Jair Jurrjens | Chad Billingsley | | 404 | 373 | 31 |
| 2008-07-09 | @ LAN | 92 | L 1-2 | 43-49 | 4 | 39,815 | Tim Hudson | Derek Lowe | Derek Lowe | Tim Hudson | Takashi Saito | 405 | 375 | 30 |
| 2008-07-11 | @ SDN | 93 | L 0-4 | 43-50 | 4 | 40,232 | Jo-Jo Reyes | Jake Peavy | Jake Peavy | Jo-Jo Reyes | Trevor Hoffman | 405 | 379 | 26 |
| 2008-07-12 | @ SDN | 94 | W 4-1 | 44-50 | 4 | 42,438 | Charlie Morton | Greg Maddux | Charlie Morton | Greg Maddux | Mike Gonzalez | 409 | 380 | 29 |
| 2008-07-13 | @ SDN | 95 | W 12-3 | 45-50 | 4 | 31,347 | Jorge Campillo | Randy Wolf | Jorge Campillo | Randy Wolf | | 421 | 383 | 38 |
| 2008-07-18 | vs WAS | 96 | W 7-6 | 46-50 | 4 | 39,861 | Tim Hudson | Tim Redding | Tim Hudson | Tim Redding | Mike Gonzalez | 428 | 389 | 39 |
| 2008-07-19 | vs WAS | 97 | L 2-8 | 46-51 | 4 | 43,285 | Jair Jurrjens | John Lannan | John Lannan | Jair Jurrjens | | 430 | 397 | 33 |
| 2008-07-20 | vs WAS | 98 | L 6-15 | 46-52 | 4 | 29,320 | Jo-Jo Reyes | Odalis Perez | Odalis Perez | Jo-Jo Reyes | | 436 | 412 | 24 |
| 2008-07-21 | @ FLO | 99 | W 4-0 | 47-52 | 4 | 14,155 | Jorge Campillo | Chris Volstad | Jorge Campillo | Chris Volstad | | 440 | 412 | 28 |
| 2008-07-22 | @ FLO | 100 | L 0-4 | 47-53 | 4 | 14,721 | Charlie Morton | Rick Vanden Hurk | Rick Vanden Hurk | Charlie Morton | | 440 | 416 | 24 |
| 2008-07-23 | @ FLO | 101 | W 9-4 | 48-53 | 4 | 16,068 | Tim Hudson | Ricky Nolasco | Tim Hudson | Ricky Nolasco | | 449 | 420 | 29 |
| 2008-07-25 | @ PHI | 102 | W 8-2 | 49-53 | 4 | 45,114 | Jair Jurrjens | Kyle Kendrick | Jair Jurrjens | Kyle Kendrick | | 457 | 422 | 35 |
| 2008-07-26 | @ PHI | 103 | L 9-10 | 49-54 | 4 | 45,107 | Mike Hampton | Cole Hamels | Adam Eaton | Blaine Boyer | Brad Lidge | 466 | 432 | 34 |
| 2008-07-27 | @ PHI | 104 | L 10-12 | 49-55 | 4 | 45,096 | Jorge Campillo | Joe Blanton | Clay Condrey | Julian Tavarez | Brad Lidge | 476 | 444 | 32 |
| 2008-07-28 | vs SLN | 105 | L 3-12 | 49-56 | 4 | 28,705 | Charlie Morton | Braden Looper | Braden Looper | Charlie Morton | | 479 | 456 | 23 |
| 2008-07-29 | vs SLN | 106 | L 3-8 | 49-57 | 4 | 29,541 | Jorge Campillo | Todd Wellemeyer | Ryan Franklin | Rafael Soriano | | 482 | 464 | 18 |
| 2008-07-30 | vs SLN | 107 | L 2-7 | 49-58 | 4 | 35,257 | Jair Jurrjens | Chris Carpenter | Brad Thompson | Jair Jurrjens | Ron Villone | 484 | 471 | 13 |
| 2008-07-31 | vs SLN | 108 | W 9-4 | 50-58 | 4 | 40,653 | Mike Hampton | Joel Pineiro | Jeff Bennett | Joel Pineiro | | 493 | 475 | 18 |
| 2008-08-01 | vs MIL | 109 | L 0-9 | 50-59 | 4 | 32,238 | Chuck James | Jeff Suppan | Jeff Suppan | Chuck James | | 493 | 484 | 9 |
| 2008-08-02 | vs MIL | 110 | L 2-4 | 50-60 | 4 | 42,096 | Charlie Morton | CC Sabathia | CC Sabathia | Charlie Morton | Salomon Torres | 495 | 488 | 7 |
| 2008-08-03 | vs MIL | 111 | W 5-0 | 51-60 | 4 | 29,177 | Jorge Campillo | Ben Sheets | Jorge Campillo | Ben Sheets | | 500 | 488 | 12 |
| 2008-08-04 | @ SFN | 112 | L 2-4 | 51-61 | 4 | 37,473 | Jair Jurrjens | Matt Cain | Matt Cain | Jair Jurrjens | Brian Wilson | 502 | 492 | 10 |
| 2008-08-05 | @ SFN | 113 | W 11-4 | 52-61 | 4 | 36,098 | Mike Hampton | Jonathan Sanchez | Mike Hampton | Jonathan Sanchez | | 513 | 496 | 17 |
| 2008-08-06 | @ SFN | 114 | L 2-3 | 52-62 | 4 | 39,955 | Chuck James | Tim Lincecum | Tim Lincecum | Chuck James | Brian Wilson | 515 | 499 | 16 |
| 2008-08-07 | @ ARI | 115 | W 6-4 | 53-62 | 4 | 27,787 | Charlie Morton | Yusmeiro Petit | Charlie Morton | Yusmeiro Petit | Mike Gonzalez | 521 | 503 | 18 |
| 2008-08-08 | @ ARI | 116 | W 11-6 | 54-62 | 4 | 27,996 | Jorge Campillo | Doug Davis | Jorge Campillo | Doug Davis | Jeff Bennett | 532 | 509 | 23 |
| 2008-08-09 | @ ARI | 117 | W 11-4 | 55-62 | 4 | 36,613 | Jair Jurrjens | Dan Haren | Jair Jurrjens | Dan Haren | | 543 | 513 | 30 |
| 2008-08-10 | @ ARI | 118 | L 1-6 | 55-63 | 4 | 35,838 | Mike Hampton | Brandon Webb | Brandon Webb | Mike Hampton | | 544 | 519 | 25 |
| 2008-08-13 | vs CHN | 119 | L 2-10 | 55-65 | 4 | 27,220 | Charlie Morton | Jason Marquis | Jason Marquis | Charlie Morton | | 546 | 529 | 17 |
| 2008-08-13 | vs CHN | 120 | L 0-8 | 55-65 | 4 | 33,714 | Jorge Campillo | Rich Harden | Rich Harden | Jorge Campillo | | 546 | 537 | 9 |
| 2008-08-14 | vs CHN | 121 | L 7-11 | 55-66 | 4 | 36,365 | Tom Glavine | Ted Lilly | Ted Lilly | Tom Glavine | | 553 | 548 | 5 |
| 2008-08-15 | vs SFN | 122 | L 1-5 | 55-67 | 4 | 30,682 | Jair Jurrjens | Matt Cain | Matt Cain | Jair Jurrjens | | 554 | 553 | 1 |
| 2008-08-16 | vs SFN | 123 | W 11-5 | 56-67 | 4 | 41,893 | Mike Hampton | Matt Palmer | Mike Hampton | Matt Palmer | | 565 | 558 | 7 |
| 2008-08-17 | vs SFN | 124 | L 1-3 | 56-68 | 4 | 30,503 | Charlie Morton | Tim Lincecum | Tim Lincecum | Charlie Morton | Brian Wilson | 566 | 561 | 5 |
| 2008-08-18 | vs SFN | 125 | L 0-5 | 56-69 | 4 | 18,113 | Jorge Campillo | Barry Zito | Barry Zito | Jorge Campillo | | 566 | 566 | 0 |
| 2008-08-19 | @ NYN | 126 | L 3-7 | 56-70 | 4 | 50,589 | Jo-Jo Reyes | Oliver Perez | Aaron Heilman | Jeff Bennett | | 569 | 573 | -4 |
| 2008-08-20 | @ NYN | 127 | L 3-6 | 56-71 | 4 | 50,178 | Jair Jurrjens | Mike Pelfrey | Mike Pelfrey | Jair Jurrjens | | 572 | 579 | -7 |
| 2008-08-21 | @ NYN | 128 | L 4-5 | 56-72 | 4 | 51,952 | Mike Hampton | Pedro Martinez | Luis Ayala | Vladimir Nunez | | 576 | 584 | -8 |
| 2008-08-22 | @ SLN | 129 | L 3-18 | 56-73 | 4 | 43,926 | Charlie Morton | Adam Wainwright | Adam Wainwright | Charlie Morton | Joel Pineiro | 579 | 602 | -23 |
| 2008-08-23 | @ SLN | 130 | W 8-4 | 57-73 | 4 | 44,074 | Jorge Campillo | Kyle Lohse | Buddy Carlyle | Kyle McClellan | Mike Gonzalez | 587 | 606 | -19 |
| 2008-08-24 | @ SLN | 131 | L 3-6 | 57-74 | 4 | 43,361 | Jo-Jo Reyes | Braden Looper | Braden Looper | Jo-Jo Reyes | Chris Perez | 590 | 612 | -22 |
| 2008-08-26 | vs FLO | 132 | W 10-9 | 58-74 | 4 | 17,539 | Jair Jurrjens | Scott Olsen | Will Ohman | Kevin Gregg | | 600 | 621 | -21 |
| 2008-08-27 | vs FLO | 133 | L 1-4 | 58-75 | 4 | 19,755 | Mike Hampton | Josh Johnson | Josh Johnson | Mike Hampton | | 601 | 625 | -24 |
| 2008-08-28 | vs FLO | 134 | W 4-2 | 59-75 | 4 | 20,155 | Charlie Morton | Anibal Sanchez | Charlie Morton | Anibal Sanchez | Mike Gonzalez | 605 | 627 | -22 |
| 2008-08-29 | @ WAS | 135 | L 3-7 | 59-76 | 4 | 22,737 | Jorge Campillo | Odalis Perez | Odalis Perez | Jorge Campillo | Joel Hanrahan | 608 | 634 | -26 |
| 2008-08-30 | @ WAS | 136 | L 8-9 | 59-77 | 4 | 30,326 | Jo-Jo Reyes | Jason Bergmann | Steven Shell | Vladimir Nunez | | 616 | 643 | -27 |
| 2008-08-31 | @ WAS | 137 | L 4-8 | 59-78 | 4 | 31,090 | Jair Jurrjens | Collin Balester | Garrett Mock | Elmer Dessens | | 620 | 651 | -31 |
| 2008-09-01 | @ FLO | 138 | L 3-4 | 59-79 | 4 | 12,209 | Mike Hampton | Josh Johnson | Matt Lindstrom | Mike Gonzalez | | 623 | 655 | -32 |
| 2008-09-02 | @ FLO | 139 | W 16-14 | 60-79 | 4 | 14,092 | Charlie Morton | Anibal Sanchez | Jorge Julio | Matt Lindstrom | Mike Gonzalez | 639 | 669 | -30 |
| 2008-09-03 | @ FLO | 140 | L 3-5 | 60-80 | 4 | 11,211 | Jorge Campillo | Chris Volstad | Doug Waechter | Will Ohman | Joe Nelson | 642 | 674 | -32 |
| 2008-09-04 | vs WAS | 141 | W 2-0 | 61-80 | 4 | 18,708 | James Parr | Shairon Martis | James Parr | Shairon Martis | Mike Gonzalez | 644 | 674 | -30 |
| 2008-09-05 | vs WAS | 142 | W 10-5 | 62-80 | 4 | 25,064 | Jair Jurrjens | Jason Bergmann | Jair Jurrjens | Jason Bergmann | | 654 | 679 | -25 |
| 2008-09-06 | vs WAS | 143 | L 5-8 | 62-81 | 4 | 34,369 | Mike Hampton | Tim Redding | Joel Hanrahan | Mike Gonzalez | Steven Shell | 659 | 687 | -28 |
| 2008-09-07 | vs WAS | 144 | L 4-7 | 62-82 | 4 | 30,753 | Jo-Jo Reyes | Collin Balester | Steven Shell | Jeff Bennett | Joel Hanrahan | 663 | 694 | -31 |
| 2008-09-09 | vs COL | 145 | W 5-4 | 63-82 | 4 | 21,821 | Jorge Campillo | Aaron Cook | Julian Tavarez | Taylor Buchholz | | 668 | 698 | -30 |
| 2008-09-10 | vs COL | 146 | W 9-5 | 64-82 | 4 | 19,693 | James Parr | Livan Hernandez | Jeff Bennett | Luis Vizcaino | | 677 | 703 | -26 |
| 2008-09-11 | vs COL | 147 | W 8-4 | 65-82 | 4 | 20,039 | Jair Jurrjens | Ubaldo Jimenez | Jair Jurrjens | Glendon Rusch | | 685 | 707 | -22 |
| 2008-09-13 | @ NYN | 148 | W 3-2 | 66-83 | 4 | 0 | Mike Hampton | Johan Santana | Jeff Ridgway | Scott Schoeneweis | Mike Gonzalez | 688 | 709 | -21 |
| 2008-09-13 | @ NYN | 149 | L 0-5 | 66-83 | 4 | 54,705 | Jo-Jo Reyes | Jonathon Niese | Jonathon Niese | Jo-Jo Reyes | | 688 | 714 | -26 |
| 2008-09-14 | @ NYN | 150 | W 7-4 | 67-83 | 4 | 56,041 | Jorge Campillo | Oliver Perez | Jorge Julio | Luis Ayala | Mike Gonzalez | 695 | 718 | -23 |
| 2008-09-16 | vs PHI | 151 | L 7-8 | 67-84 | 4 | 30,319 | James Parr | Jamie Moyer | Ryan Madson | Mike Gonzalez | Brad Lidge | 702 | 726 | -24 |
| 2008-09-17 | vs PHI | 152 | L 1-6 | 67-85 | 4 | 32,821 | Jair Jurrjens | J.A. Happ | J.A. Happ | Jair Jurrjens | | 703 | 732 | -29 |
| 2008-09-18 | vs PHI | 153 | L 3-4 | 67-86 | 4 | 39,070 | Mike Hampton | Cole Hamels | Cole Hamels | Mike Hampton | Brad Lidge | 706 | 736 | -30 |
| 2008-09-19 | vs NYN | 154 | L 5-9 | 67-87 | 4 | 42,803 | Jo-Jo Reyes | Oliver Perez | Pedro Feliciano | Julian Tavarez | | 711 | 745 | -34 |
| 2008-09-20 | vs NYN | 155 | W 4-2 | 68-87 | 4 | 50,124 | Jorge Campillo | Pedro Martinez | Jorge Campillo | Pedro Martinez | Mike Gonzalez | 715 | 747 | -32 |
| 2008-09-21 | vs NYN | 156 | W 7-6 | 69-87 | 4 | 49,222 | James Parr | Mike Pelfrey | Jorge Julio | Scott Schoeneweis | Mike Gonzalez | 722 | 753 | -31 |
| 2008-09-22 | @ PHI | 157 | L 2-6 | 69-88 | 4 | 36,796 | Jair Jurrjens | J.A. Happ | Scott Eyre | Jeff Bennett | | 724 | 759 | -35 |
| 2008-09-23 | @ PHI | 158 | W 3-2 | 70-88 | 4 | 39,322 | Mike Hampton | Cole Hamels | Mike Hampton | Cole Hamels | Mike Gonzalez | 727 | 761 | -34 |
| 2008-09-24 | @ PHI | 159 | W 10-4 | 71-88 | 4 | 41,430 | Jo-Jo Reyes | Brett Myers | Buddy Carlyle | Brett Myers | | 737 | 765 | -28 |
| 2008-09-26 | @ HOU | 160 | L 4-5 | 71-89 | 4 | 33,477 | Jorge Campillo | Brian Moehler | Jose Valverde | Julian Tavarez | | 741 | 770 | -29 |
| 2008-09-27 | @ HOU | 161 | W 11-5 | 72-89 | 4 | 37,491 | James Parr | Brandon Backe | Vladimir Nunez | Brandon Backe | | 752 | 775 | -23 |
| 2008-09-28 | @ HOU | 162 | L 1-3 | 72-90 | 4 | 37,113 | Mike Hampton | Wandy Rodriguez | Wandy Rodriguez | Mike Hampton | Jose Valverde | 753 | 778 | -25 |