| 2008-04-01 | vs COL | 1 | L 1-2 | 0-1 | 6 | 45,996 | Kyle Lohse | Kip Wells | Taylor Buchholz | Ryan Franklin | Manuel Corpas | 1 | 2 | -1 |
| 2008-04-02 | vs COL | 2 | W 8-3 | 1-1 | 4 | 39,915 | Todd Wellemeyer | Aaron Cook | Todd Wellemeyer | Aaron Cook | | 9 | 5 | 4 |
| 2008-04-03 | vs COL | 3 | W 3-0 | 2-1 | 4 | 33,748 | Brad Thompson | Ubaldo Jimenez | Brad Thompson | Ubaldo Jimenez | Jason Isringhausen | 12 | 5 | 7 |
| 2008-04-04 | vs WAS | 4 | W 5-4 | 3-1 | 2 | 37,191 | Braden Looper | Odalis Perez | Braden Looper | Odalis Perez | Jason Isringhausen | 17 | 9 | 8 |
| 2008-04-05 | vs WAS | 5 | W 5-4 | 4-1 | 2 | 41,463 | Adam Wainwright | Matt Chico | Adam Wainwright | Matt Chico | Randy Flores | 22 | 13 | 9 |
| 2008-04-06 | vs WAS | 6 | W 3-0 | 5-1 | 2 | 41,912 | Kyle Lohse | John Lannan | Kyle Lohse | John Lannan | Jason Isringhausen | 25 | 13 | 12 |
| 2008-04-07 | @ HOU | 7 | L 3-5 | 5-2 | 2 | 43,483 | Todd Wellemeyer | Wandy Rodriguez | Jose Valverde | Kyle McClellan | | 28 | 18 | 10 |
| 2008-04-08 | @ HOU | 8 | W 5-3 | 6-2 | 2 | 30,184 | Brad Thompson | Shawn Chacon | Anthony Reyes | Geoff Geary | Jason Isringhausen | 33 | 21 | 12 |
| 2008-04-09 | @ HOU | 9 | W 6-4 | 7-2 | 1 | 29,187 | Braden Looper | Chris Sampson | Braden Looper | Chris Sampson | Jason Isringhausen | 39 | 25 | 14 |
| 2008-04-10 | @ SFN | 10 | L 1-5 | 7-3 | 1 | 30,333 | Adam Wainwright | Kevin Correia | Kevin Correia | Adam Wainwright | Brian Wilson | 40 | 30 | 10 |
| 2008-04-11 | @ SFN | 11 | W 8-2 | 8-3 | 1 | 33,954 | Kyle Lohse | Barry Zito | Kyle Lohse | Barry Zito | | 48 | 32 | 16 |
| 2008-04-12 | @ SFN | 12 | W 8-7 | 9-3 | 1 | 35,717 | Todd Wellemeyer | Matt Cain | Jason Isringhausen | Erick Threets | Anthony Reyes | 56 | 39 | 17 |
| 2008-04-13 | @ SFN | 13 | L 4-7 | 9-4 | 1 | 37,195 | Joel Pineiro | Tim Lincecum | Tim Lincecum | Joel Pineiro | Brian Wilson | 60 | 46 | 14 |
| 2008-04-15 | vs MIL | 14 | W 6-1 | 10-4 | 1 | 39,438 | Braden Looper | David Bush | Braden Looper | David Bush | | 66 | 47 | 19 |
| 2008-04-16 | vs MIL | 15 | W 5-4 | 11-4 | 1 | 40,712 | Adam Wainwright | Carlos Villanueva | Adam Wainwright | Carlos Villanueva | Jason Isringhausen | 71 | 51 | 20 |
| 2008-04-17 | vs MIL | 16 | L 3-5 | 11-5 | 1 | 36,850 | Kyle Lohse | Manny Parra | Brian Shouse | Brad Thompson | Eric Gagne | 74 | 56 | 18 |
| 2008-04-18 | vs SFN | 17 | W 11-1 | 12-5 | 1 | 40,684 | Todd Wellemeyer | Matt Cain | Todd Wellemeyer | Matt Cain | | 85 | 57 | 28 |
| 2008-04-19 | vs SFN | 18 | L 0-3 | 12-6 | 1 | 41,707 | Joel Pineiro | Tim Lincecum | Tim Lincecum | Joel Pineiro | Brian Wilson | 85 | 60 | 25 |
| 2008-04-20 | vs SFN | 19 | L 2-8 | 12-7 | 2 | 41,127 | Braden Looper | Jonathan Sanchez | Jonathan Sanchez | Braden Looper | | 87 | 68 | 19 |
| 2008-04-21 | @ MIL | 20 | W 4-3 | 13-7 | 2 | 31,240 | Adam Wainwright | Carlos Villanueva | Ryan Franklin | Derrick Turnbow | Jason Isringhausen | 91 | 71 | 20 |
| 2008-04-22 | @ MIL | 21 | L 8-9 | 13-8 | 2 | 23,748 | Kyle Lohse | Manny Parra | Seth McClung | Jason Isringhausen | | 99 | 80 | 19 |
| 2008-04-23 | @ PIT | 22 | L 4-7 | 13-9 | 3 | 10,487 | Todd Wellemeyer | Ian Snell | Damaso Marte | Anthony Reyes | Matt Capps | 103 | 87 | 16 |
| 2008-04-24 | @ PIT | 23 | W 6-2 | 14-9 | 2 | 9,544 | Joel Pineiro | Tom Gorzelanny | Joel Pineiro | Tom Gorzelanny | Jason Isringhausen | 109 | 89 | 20 |
| 2008-04-25 | vs HOU | 24 | L 2-3 | 14-10 | 2 | 41,193 | Braden Looper | Shawn Chacon | Wesley Wright | Jason Isringhausen | Jose Valverde | 111 | 92 | 19 |
| 2008-04-26 | vs HOU | 25 | W 4-3 | 15-10 | 2 | 43,040 | Adam Wainwright | Roy Oswalt | Adam Wainwright | Dave Borkowski | | 115 | 95 | 20 |
| 2008-04-27 | vs HOU | 26 | W 5-1 | 16-10 | 2 | 44,222 | Kyle Lohse | Brandon Backe | Kyle Lohse | Brandon Backe | Kyle McClellan | 120 | 96 | 24 |
| 2008-04-28 | vs CIN | 27 | L 3-4 | 16-11 | 2 | 37,229 | Todd Wellemeyer | Bronson Arroyo | Bronson Arroyo | Todd Wellemeyer | Francisco Cordero | 123 | 100 | 23 |
| 2008-04-29 | vs CIN | 28 | W 7-2 | 17-11 | 2 | 35,356 | Joel Pineiro | Johnny Cueto | Joel Pineiro | Johnny Cueto | | 130 | 102 | 28 |
| 2008-04-30 | vs CIN | 29 | W 5-2 | 18-11 | 2 | 40,629 | Braden Looper | Aaron Harang | Braden Looper | Aaron Harang | Jason Isringhausen | 135 | 104 | 31 |
| 2008-05-02 | vs CHN | 30 | W 5-3 | 19-11 | 1 | 45,077 | Adam Wainwright | Rich Hill | Ron Villone | Chad Fox | | 140 | 107 | 33 |
| 2008-05-03 | vs CHN | 31 | L 3-9 | 19-12 | 1 | 46,792 | Kyle Lohse | Ted Lilly | Ted Lilly | Kyle Lohse | | 143 | 116 | 27 |
| 2008-05-04 | vs CHN | 32 | W 5-3 | 20-12 | 1 | 44,969 | Todd Wellemeyer | Jason Marquis | Todd Wellemeyer | Jason Marquis | Jason Isringhausen | 148 | 119 | 29 |
| 2008-05-05 | @ COL | 33 | W 6-5 | 21-12 | 1 | 28,183 | Joel Pineiro | Ubaldo Jimenez | Randy Flores | Brian Fuentes | Jason Isringhausen | 154 | 124 | 30 |
| 2008-05-06 | @ COL | 34 | W 6-5 | 22-12 | 1 | 25,460 | Braden Looper | Mark Redman | Braden Looper | Mark Redman | Ryan Franklin | 160 | 129 | 31 |
| 2008-05-07 | @ COL | 35 | L 3-4 | 22-13 | 1 | 25,432 | Adam Wainwright | Jeff Francis | Ryan Speier | Jason Isringhausen | Brian Fuentes | 163 | 133 | 30 |
| 2008-05-08 | @ COL | 36 | L 3-9 | 22-14 | 1 | 25,376 | Kyle Lohse | Jorge de la Rosa | Jorge de la Rosa | Kyle Lohse | | 166 | 142 | 24 |
| 2008-05-09 | @ MIL | 37 | L 3-4 | 22-15 | 1 | 42,705 | Todd Wellemeyer | Manny Parra | Brian Shouse | Jason Isringhausen | | 169 | 146 | 23 |
| 2008-05-10 | @ MIL | 38 | W 5-3 | 23-15 | 1 | 43,382 | Joel Pineiro | Ben Sheets | Russ Springer | Eric Gagne | Ryan Franklin | 174 | 149 | 25 |
| 2008-05-11 | @ MIL | 39 | L 3-5 | 23-16 | 2 | 41,197 | Braden Looper | Jeff Suppan | Jeff Suppan | Braden Looper | Brian Shouse | 177 | 154 | 23 |
| 2008-05-12 | @ MIL | 40 | L 3-8 | 23-17 | 2 | 25,757 | Adam Wainwright | David Bush | David Bush | Adam Wainwright | Guillermo Mota | 180 | 162 | 18 |
| 2008-05-13 | vs PIT | 41 | L 4-8 | 23-18 | 2 | 38,800 | Kyle Lohse | Phil Dumatrait | Marino Salas | Ron Villone | | 184 | 170 | 14 |
| 2008-05-14 | vs PIT | 42 | W 5-1 | 24-18 | 2 | 38,720 | Todd Wellemeyer | Paul Maholm | Todd Wellemeyer | Paul Maholm | | 189 | 171 | 18 |
| 2008-05-15 | vs PIT | 43 | L 5-11 | 24-19 | 3 | 41,244 | Joel Pineiro | Ian Snell | John Grabow | Jason Isringhausen | | 194 | 182 | 12 |
| 2008-05-16 | vs TBA | 44 | L 1-3 | 24-20 | 3 | 43,136 | Braden Looper | Andy Sonnanstine | Andy Sonnanstine | Braden Looper | Troy Percival | 195 | 185 | 10 |
| 2008-05-17 | vs TBA | 45 | W 9-8 | 25-20 | 2 | 43,907 | Adam Wainwright | Matt Garza | Ryan Franklin | Dan Wheeler | | 204 | 193 | 11 |
| 2008-05-18 | vs TBA | 46 | W 5-4 | 26-20 | 2 | 46,392 | Kyle Lohse | Edwin Jackson | Chris Perez | Gary Glover | | 209 | 197 | 12 |
| 2008-05-19 | @ SDN | 47 | W 8-2 | 27-20 | 2 | 22,638 | Todd Wellemeyer | Wil Ledezma | Todd Wellemeyer | Wil Ledezma | | 217 | 199 | 18 |
| 2008-05-20 | @ SDN | 48 | L 2-3 | 27-21 | 2 | 27,181 | Joel Pineiro | Greg Maddux | Bryan Corey | Joel Pineiro | Trevor Hoffman | 219 | 202 | 17 |
| 2008-05-21 | @ SDN | 49 | W 11-3 | 28-21 | 2 | 21,011 | Braden Looper | Chris Young | Braden Looper | Chris Young | | 230 | 205 | 25 |
| 2008-05-23 | @ LAN | 50 | W 2-1 | 29-21 | 2 | 52,281 | Adam Wainwright | Derek Lowe | Adam Wainwright | Derek Lowe | Ryan Franklin | 232 | 206 | 26 |
| 2008-05-24 | @ LAN | 51 | W 4-0 | 30-21 | 2 | 44,785 | Kyle Lohse | Brad Penny | Kyle Lohse | Brad Penny | | 236 | 206 | 30 |
| 2008-05-25 | @ LAN | 52 | L 3-4 | 30-22 | 2 | 46,566 | Todd Wellemeyer | Clayton Kershaw | Takashi Saito | Mike Parisi | | 239 | 210 | 29 |
| 2008-05-27 | vs HOU | 53 | L 2-8 | 30-23 | 3 | 41,104 | Braden Looper | Shawn Chacon | Shawn Chacon | Braden Looper | | 241 | 218 | 23 |
| 2008-05-28 | vs HOU | 54 | W 6-1 | 31-23 | 2 | 41,115 | Adam Wainwright | Wandy Rodriguez | Adam Wainwright | Wandy Rodriguez | | 247 | 219 | 28 |
| 2008-05-29 | vs HOU | 55 | W 3-2 | 32-23 | 2 | 41,786 | Kyle Lohse | Roy Oswalt | Kyle Lohse | Roy Oswalt | Ryan Franklin | 250 | 221 | 29 |
| 2008-05-30 | vs PIT | 56 | W 5-4 | 33-23 | 2 | 42,791 | Todd Wellemeyer | Zach Duke | Todd Wellemeyer | Zach Duke | Ryan Franklin | 255 | 225 | 30 |
| 2008-05-31 | vs PIT | 57 | L 4-14 | 33-24 | 2 | 44,302 | Mike Parisi | Paul Maholm | Paul Maholm | Mike Parisi | | 259 | 239 | 20 |
| 2008-06-01 | vs PIT | 58 | W 7-4 | 34-24 | 2 | 43,462 | Braden Looper | Ian Snell | Braden Looper | Ian Snell | Ryan Franklin | 266 | 243 | 23 |
| 2008-06-02 | vs PIT | 59 | L 4-5 | 34-25 | 2 | 42,129 | Adam Wainwright | Tom Gorzelanny | Franquelis Osoria | Adam Wainwright | Matt Capps | 270 | 248 | 22 |
| 2008-06-03 | @ WAS | 60 | W 6-1 | 35-25 | 2 | 26,875 | Kyle Lohse | Odalis Perez | Kyle Lohse | Odalis Perez | | 276 | 249 | 27 |
| 2008-06-05 | @ WAS | 61 | W 4-1 | 36-26 | 2 | 27,264 | Todd Wellemeyer | John Lannan | Todd Wellemeyer | John Lannan | Ryan Franklin | 280 | 250 | 30 |
| 2008-06-05 | @ WAS | 62 | L 9-10 | 36-26 | 2 | 32,357 | Mike Parisi | Tim Redding | Brian Sanches | Ryan Franklin | | 289 | 260 | 29 |
| 2008-06-06 | @ HOU | 63 | L 1-6 | 36-27 | 2 | 38,596 | Braden Looper | Brian Moehler | Brian Moehler | Braden Looper | | 290 | 266 | 24 |
| 2008-06-07 | @ HOU | 64 | W 8-4 | 37-27 | 2 | 39,811 | Adam Wainwright | Shawn Chacon | Adam Wainwright | Shawn Chacon | | 298 | 270 | 28 |
| 2008-06-08 | @ HOU | 65 | W 5-4 | 38-27 | 2 | 39,923 | Kyle Lohse | Wandy Rodriguez | Kyle Lohse | Wandy Rodriguez | Ryan Franklin | 303 | 274 | 29 |
| 2008-06-10 | @ CIN | 66 | W 7-2 | 39-27 | 2 | 34,234 | Mitchell Boggs | Homer Bailey | Mitchell Boggs | Homer Bailey | | 310 | 276 | 34 |
| 2008-06-11 | @ CIN | 67 | W 10-0 | 40-27 | 2 | 19,851 | Braden Looper | Johnny Cueto | Braden Looper | Johnny Cueto | | 320 | 276 | 44 |
| 2008-06-12 | @ CIN | 68 | L 2-6 | 40-28 | 2 | 22,121 | Joel Pineiro | Bronson Arroyo | Jared Burton | Mark Worrell | | 322 | 282 | 40 |
| 2008-06-13 | vs PHI | 69 | L 2-20 | 40-29 | 2 | 44,376 | Todd Wellemeyer | Kyle Kendrick | Kyle Kendrick | Todd Wellemeyer | | 324 | 302 | 22 |
| 2008-06-14 | vs PHI | 70 | W 3-2 | 41-29 | 2 | 45,089 | Kyle Lohse | Adam Eaton | Kyle Lohse | Adam Eaton | Ryan Franklin | 327 | 304 | 23 |
| 2008-06-15 | vs PHI | 71 | W 7-6 | 42-29 | 2 | 45,391 | Mitchell Boggs | Brett Myers | Anthony Reyes | Tom Gordon | | 334 | 310 | 24 |
| 2008-06-17 | vs KCA | 72 | L 1-2 | 42-30 | 2 | 43,793 | Joel Pineiro | Kyle Davies | Kyle Davies | Ron Villone | Joakim Soria | 335 | 312 | 23 |
| 2008-06-18 | vs KCA | 73 | L 2-3 | 42-31 | 2 | 43,810 | Braden Looper | Brian Bannister | Brian Bannister | Kyle McClellan | Joakim Soria | 337 | 315 | 22 |
| 2008-06-19 | vs KCA | 74 | L 1-4 | 42-32 | 2 | 44,277 | Brad Thompson | Zack Greinke | Zack Greinke | Brad Thompson | Joakim Soria | 338 | 319 | 19 |
| 2008-06-20 | @ BOS | 75 | W 5-4 | 43-32 | 2 | 37,671 | Kyle Lohse | Tim Wakefield | Kyle Lohse | Tim Wakefield | Ryan Franklin | 343 | 323 | 20 |
| 2008-06-21 | @ BOS | 76 | W 9-3 | 44-32 | 2 | 37,227 | Mitchell Boggs | Daisuke Matsuzaka | Mitchell Boggs | Daisuke Matsuzaka | | 352 | 326 | 26 |
| 2008-06-22 | @ BOS | 77 | L 3-5 | 44-33 | 2 | 37,085 | Joel Pineiro | Jon Lester | Javier Lopez | Mike Parisi | | 355 | 331 | 24 |
| 2008-06-24 | @ DET | 78 | W 8-4 | 45-33 | 2 | 44,446 | Braden Looper | Kenny Rogers | Braden Looper | Kenny Rogers | | 363 | 335 | 28 |
| 2008-06-25 | @ DET | 79 | L 7-8 | 45-34 | 2 | 40,091 | Kyle Lohse | Armando Galarraga | Todd Jones | Kyle McClellan | | 370 | 343 | 27 |
| 2008-06-26 | @ DET | 80 | L 2-3 | 45-35 | 2 | 41,022 | Todd Wellemeyer | Nate Robertson | Bobby Seay | Mike Parisi | | 372 | 346 | 26 |
| 2008-06-27 | @ KCA | 81 | L 2-7 | 45-36 | 2 | 36,360 | Joel Pineiro | Gil Meche | Gil Meche | Joel Pineiro | | 374 | 353 | 21 |
| 2008-06-28 | @ KCA | 82 | W 5-1 | 46-36 | 2 | 37,537 | Mitchell Boggs | Kyle Davies | Mitchell Boggs | Kyle Davies | | 379 | 354 | 25 |
| 2008-06-29 | @ KCA | 83 | W 9-6 | 47-36 | 2 | 31,803 | Braden Looper | Brian Bannister | Chris Perez | Brian Bannister | Ryan Franklin | 388 | 360 | 28 |
| 2008-06-30 | vs NYN | 84 | W 7-1 | 48-36 | 2 | 42,206 | Kyle Lohse | John Maine | Kyle Lohse | John Maine | | 395 | 361 | 34 |
| 2008-07-01 | vs NYN | 85 | L 4-7 | 48-37 | 2 | 42,425 | Todd Wellemeyer | Tony Armas | Tony Armas | Todd Wellemeyer | Billy Wagner | 399 | 368 | 31 |
| 2008-07-02 | vs NYN | 86 | W 8-7 | 49-37 | 2 | 40,995 | Joel Pineiro | Pedro Martinez | Ryan Franklin | Carlos Muniz | | 407 | 375 | 32 |
| 2008-07-03 | vs NYN | 87 | L 1-11 | 49-38 | 2 | 43,099 | Mitchell Boggs | Mike Pelfrey | Mike Pelfrey | Mitchell Boggs | | 408 | 386 | 22 |
| 2008-07-04 | vs CHN | 88 | L 1-2 | 49-39 | 2 | 46,450 | Braden Looper | Carlos Zambrano | Carlos Zambrano | Braden Looper | Kerry Wood | 409 | 388 | 21 |
| 2008-07-05 | vs CHN | 89 | W 5-4 | 50-39 | 2 | 46,865 | Kyle Lohse | Ted Lilly | Kyle McClellan | Kerry Wood | | 414 | 392 | 22 |
| 2008-07-06 | vs CHN | 90 | L 1-7 | 50-40 | 3 | 46,752 | Todd Wellemeyer | Sean Marshall | Sean Marshall | Todd Wellemeyer | | 415 | 399 | 16 |
| 2008-07-08 | @ PHI | 91 | W 2-0 | 51-40 | 2 | 41,519 | Joel Pineiro | Cole Hamels | Joel Pineiro | Cole Hamels | Ryan Franklin | 417 | 399 | 18 |
| 2008-07-09 | @ PHI | 92 | L 2-4 | 51-41 | 2 | 44,951 | Mark Mulder | J.A. Happ | Clay Condrey | Kyle McClellan | Brad Lidge | 419 | 403 | 16 |
| 2008-07-10 | @ PHI | 93 | L 1-4 | 51-42 | 3 | 44,241 | Braden Looper | Jamie Moyer | Jamie Moyer | Braden Looper | J.C. Romero | 420 | 407 | 13 |
| 2008-07-11 | @ PIT | 94 | W 6-0 | 52-42 | 2 | 37,113 | Kyle Lohse | Zach Duke | Kyle Lohse | Zach Duke | | 426 | 407 | 19 |
| 2008-07-12 | @ PIT | 95 | L 11-12 | 52-43 | 2 | 29,387 | Todd Wellemeyer | Yoslan Herrera | Denny Bautista | Chris Perez | | 437 | 419 | 18 |
| 2008-07-13 | @ PIT | 96 | W 11-6 | 53-43 | 2 | 21,052 | Joel Pineiro | Ian Snell | Russ Springer | Franquelis Osoria | | 448 | 425 | 23 |
| 2008-07-17 | vs SDN | 97 | W 4-3 | 54-43 | 2 | 42,148 | Kyle Lohse | Jake Peavy | Kyle Lohse | Jake Peavy | Ryan Franklin | 452 | 428 | 24 |
| 2008-07-18 | vs SDN | 98 | W 11-7 | 55-43 | 2 | 44,398 | Braden Looper | Greg Maddux | Kyle McClellan | Heath Bell | | 463 | 435 | 28 |
| 2008-07-19 | vs SDN | 99 | W 6-5 | 56-43 | 2 | 45,399 | Todd Wellemeyer | Randy Wolf | Todd Wellemeyer | Randy Wolf | Ryan Franklin | 469 | 440 | 29 |
| 2008-07-20 | vs SDN | 100 | W 9-5 | 57-43 | 2 | 44,214 | Jaime Garcia | Cha-Seung Baek | Brad Thompson | Bryan Corey | | 478 | 445 | 33 |
| 2008-07-21 | vs MIL | 101 | L 3-6 | 57-44 | 3 | 41,006 | Joel Pineiro | Seth McClung | Salomon Torres | Ryan Franklin | | 481 | 451 | 30 |
| 2008-07-22 | vs MIL | 102 | L 3-4 | 57-45 | 3 | 41,955 | Kyle Lohse | Jeff Suppan | Brian Shouse | Kyle McClellan | Salomon Torres | 484 | 455 | 29 |
| 2008-07-23 | vs MIL | 103 | L 0-3 | 57-46 | 3 | 41,513 | Braden Looper | CC Sabathia | CC Sabathia | Braden Looper | | 484 | 458 | 26 |
| 2008-07-24 | vs MIL | 104 | L 3-4 | 57-47 | 3 | 41,233 | Todd Wellemeyer | Ben Sheets | Eric Gagne | Ryan Franklin | Salomon Torres | 487 | 462 | 25 |
| 2008-07-25 | @ NYN | 105 | L 2-7 | 57-48 | 3 | 55,372 | Mitchell Boggs | Mike Pelfrey | Mike Pelfrey | Mitchell Boggs | | 489 | 469 | 20 |
| 2008-07-26 | @ NYN | 106 | W 10-8 | 58-48 | 3 | 53,799 | Joel Pineiro | Brandon Knight | Brad Thompson | Aaron Heilman | | 499 | 477 | 22 |
| 2008-07-27 | @ NYN | 107 | L 1-9 | 58-49 | 3 | 53,691 | Kyle Lohse | Johan Santana | Johan Santana | Kyle Lohse | | 500 | 486 | 14 |
| 2008-07-28 | @ ATL | 108 | W 12-3 | 59-49 | 3 | 28,705 | Braden Looper | Charlie Morton | Braden Looper | Charlie Morton | | 512 | 489 | 23 |
| 2008-07-29 | @ ATL | 109 | W 8-3 | 60-49 | 3 | 29,541 | Todd Wellemeyer | Jorge Campillo | Ryan Franklin | Rafael Soriano | | 520 | 492 | 28 |
| 2008-07-30 | @ ATL | 110 | W 7-2 | 61-49 | 3 | 35,257 | Chris Carpenter | Jair Jurrjens | Brad Thompson | Jair Jurrjens | Ron Villone | 527 | 494 | 33 |
| 2008-07-31 | @ ATL | 111 | L 4-9 | 61-50 | 3 | 40,653 | Joel Pineiro | Mike Hampton | Jeff Bennett | Joel Pineiro | | 531 | 503 | 28 |
| 2008-08-01 | vs PHI | 112 | W 6-3 | 62-50 | 3 | 44,234 | Kyle Lohse | Cole Hamels | Kyle Lohse | Cole Hamels | Jason Isringhausen | 537 | 506 | 31 |
| 2008-08-02 | vs PHI | 113 | L 1-2 | 62-51 | 3 | 45,450 | Braden Looper | Joe Blanton | Joe Blanton | Braden Looper | Brad Lidge | 538 | 508 | 30 |
| 2008-08-03 | vs PHI | 114 | L 4-5 | 62-52 | 3 | 44,655 | Todd Wellemeyer | Brett Myers | Chad Durbin | Jaime Garcia | Brad Lidge | 542 | 513 | 29 |
| 2008-08-05 | vs LAN | 115 | W 6-4 | 63-52 | 3 | 40,773 | Chris Carpenter | Chad Billingsley | Jaime Garcia | Jason Johnson | | 548 | 517 | 31 |
| 2008-08-06 | vs LAN | 116 | W 9-6 | 64-52 | 3 | 42,581 | Joel Pineiro | Derek Lowe | Joel Pineiro | Derek Lowe | Chris Perez | 557 | 523 | 34 |
| 2008-08-07 | vs LAN | 117 | L 1-4 | 64-53 | 3 | 40,500 | Kyle Lohse | Clayton Kershaw | Clayton Kershaw | Kyle Lohse | Jonathan Broxton | 558 | 527 | 31 |
| 2008-08-08 | @ CHN | 118 | L 2-3 | 64-54 | 3 | 41,539 | Braden Looper | Ted Lilly | Bob Howry | Ryan Franklin | | 560 | 530 | 30 |
| 2008-08-09 | @ CHN | 119 | W 12-3 | 65-54 | 3 | 41,436 | Todd Wellemeyer | Carlos Zambrano | Todd Wellemeyer | Carlos Zambrano | | 572 | 533 | 39 |
| 2008-08-10 | @ CHN | 120 | L 2-6 | 65-55 | 3 | 41,268 | Chris Carpenter | Ryan Dempster | Ryan Dempster | Chris Carpenter | | 574 | 539 | 35 |
| 2008-08-11 | @ FLO | 121 | W 4-2 | 66-55 | 3 | 13,419 | Joel Pineiro | Anibal Sanchez | Joel Pineiro | Anibal Sanchez | Chris Perez | 578 | 541 | 37 |
| 2008-08-12 | @ FLO | 122 | L 3-4 | 66-56 | 3 | 14,211 | Kyle Lohse | Chris Volstad | Chris Volstad | Kyle Lohse | Kevin Gregg | 581 | 545 | 36 |
| 2008-08-13 | @ FLO | 123 | W 6-4 | 67-56 | 3 | 15,223 | Braden Looper | Ricky Nolasco | Braden Looper | Renyel Pinto | Chris Perez | 587 | 549 | 38 |
| 2008-08-14 | @ FLO | 124 | W 3-0 | 68-56 | 3 | 15,609 | Todd Wellemeyer | Scott Olsen | Todd Wellemeyer | Scott Olsen | | 590 | 549 | 41 |
| 2008-08-15 | @ CIN | 125 | W 5-3 | 69-56 | 3 | 26,234 | Brad Thompson | Bronson Arroyo | Brad Thompson | Bronson Arroyo | Chris Perez | 595 | 552 | 43 |
| 2008-08-16 | @ CIN | 126 | W 9-3 | 70-56 | 3 | 30,713 | Joel Pineiro | Aaron Harang | Joel Pineiro | Aaron Harang | | 604 | 555 | 49 |
| 2008-08-17 | @ CIN | 127 | L 3-7 | 70-57 | 3 | 37,468 | Kyle Lohse | Edinson Volquez | Edinson Volquez | Kyle Lohse | | 607 | 562 | 45 |
| 2008-08-19 | vs PIT | 128 | L 1-4 | 70-58 | 3 | 39,502 | Braden Looper | Ian Snell | Ian Snell | Braden Looper | T.J. Beam | 608 | 566 | 42 |
| 2008-08-20 | vs PIT | 129 | W 11-2 | 71-58 | 3 | 37,269 | Todd Wellemeyer | Jason Davis | Todd Wellemeyer | Jason Davis | | 619 | 568 | 51 |
| 2008-08-22 | vs ATL | 130 | W 18-3 | 72-58 | 3 | 43,926 | Adam Wainwright | Charlie Morton | Adam Wainwright | Charlie Morton | Joel Pineiro | 637 | 571 | 66 |
| 2008-08-23 | vs ATL | 131 | L 4-8 | 72-59 | 3 | 44,074 | Kyle Lohse | Jorge Campillo | Buddy Carlyle | Kyle McClellan | Mike Gonzalez | 641 | 579 | 62 |
| 2008-08-24 | vs ATL | 132 | W 6-3 | 73-59 | 3 | 43,361 | Braden Looper | Jo-Jo Reyes | Braden Looper | Jo-Jo Reyes | Chris Perez | 647 | 582 | 65 |
| 2008-08-26 | vs MIL | 133 | L 0-12 | 73-60 | 3 | 41,121 | Todd Wellemeyer | Ben Sheets | Ben Sheets | Todd Wellemeyer | | 647 | 594 | 53 |
| 2008-08-27 | vs MIL | 134 | W 5-3 | 74-60 | 3 | 41,433 | Adam Wainwright | Manny Parra | Ryan Franklin | David Riske | Chris Perez | 652 | 597 | 55 |
| 2008-08-29 | @ HOU | 135 | L 2-3 | 74-61 | 3 | 33,347 | Kyle Lohse | Randy Wolf | Doug Brocail | Russ Springer | | 654 | 600 | 54 |
| 2008-08-30 | @ HOU | 136 | L 5-8 | 74-62 | 3 | 37,569 | Braden Looper | Brian Moehler | Brian Moehler | Braden Looper | Jose Valverde | 659 | 608 | 51 |
| 2008-08-31 | @ HOU | 137 | L 0-3 | 74-63 | 3 | 35,638 | Todd Wellemeyer | Wandy Rodriguez | Wandy Rodriguez | Todd Wellemeyer | Jose Valverde | 659 | 611 | 48 |
| 2008-09-01 | @ ARI | 138 | L 6-8 | 74-64 | 3 | 35,075 | Joel Pineiro | Randy Johnson | Chad Qualls | Kyle McClellan | Brandon Lyon | 665 | 619 | 46 |
| 2008-09-02 | @ ARI | 139 | W 8-2 | 75-64 | 3 | 27,568 | Adam Wainwright | Yusmeiro Petit | Adam Wainwright | Yusmeiro Petit | | 673 | 621 | 52 |
| 2008-09-03 | @ ARI | 140 | L 3-4 | 75-65 | 3 | 24,350 | Kyle Lohse | Doug Davis | Chad Qualls | Chris Perez | | 676 | 625 | 51 |
| 2008-09-05 | vs FLO | 141 | L 1-4 | 75-66 | 3 | 42,633 | Braden Looper | Ricky Nolasco | Arthur Rhodes | Ryan Franklin | Matt Lindstrom | 677 | 629 | 48 |
| 2008-09-06 | vs FLO | 142 | W 5-3 | 76-66 | 3 | 42,814 | Todd Wellemeyer | Scott Olsen | Todd Wellemeyer | Scott Olsen | Ryan Franklin | 682 | 632 | 50 |
| 2008-09-07 | vs FLO | 143 | W 3-1 | 77-66 | 3 | 46,045 | Adam Wainwright | Josh Johnson | Adam Wainwright | Josh Johnson | Chris Perez | 685 | 633 | 52 |
| 2008-09-09 | vs CHN | 144 | W 4-3 | 78-66 | 3 | 43,806 | Kyle Lohse | Ryan Dempster | Chris Perez | Carlos Marmol | | 689 | 636 | 53 |
| 2008-09-10 | vs CHN | 145 | L 3-4 | 78-67 | 4 | 43,955 | Braden Looper | Ted Lilly | Ted Lilly | Braden Looper | Kerry Wood | 692 | 640 | 52 |
| 2008-09-11 | vs CHN | 146 | L 2-3 | 78-68 | 4 | 44,155 | Todd Wellemeyer | Rich Harden | Rich Harden | Todd Wellemeyer | Kerry Wood | 694 | 643 | 51 |
| 2008-09-12 | @ PIT | 147 | L 2-10 | 78-69 | 4 | 14,903 | Joel Pineiro | Paul Maholm | Paul Maholm | Joel Pineiro | | 696 | 653 | 43 |
| 2008-09-13 | @ PIT | 148 | L 6-7 | 78-70 | 4 | 17,132 | Adam Wainwright | Ian Snell | Craig Hansen | Chris Perez | | 702 | 660 | 42 |
| 2008-09-14 | @ PIT | 149 | L 2-7 | 78-71 | 4 | 18,994 | Brad Thompson | Jason Davis | T.J. Beam | Brad Thompson | | 704 | 667 | 37 |
| 2008-09-16 | @ CIN | 150 | L 2-7 | 78-72 | 4 | 19,708 | Braden Looper | Bronson Arroyo | Bronson Arroyo | Braden Looper | | 706 | 674 | 32 |
| 2008-09-17 | @ CIN | 151 | L 0-3 | 78-73 | 4 | 14,850 | Todd Wellemeyer | Aaron Harang | Aaron Harang | Todd Wellemeyer | | 706 | 677 | 29 |
| 2008-09-18 | @ CIN | 152 | W 5-4 | 79-73 | 4 | 14,041 | Kyle Lohse | Edinson Volquez | Kyle Lohse | Edinson Volquez | Jason Motte | 711 | 681 | 30 |
| 2008-09-19 | @ CHN | 153 | W 12-6 | 80-73 | 4 | 40,972 | Adam Wainwright | Carlos Zambrano | Adam Wainwright | Carlos Zambrano | | 723 | 687 | 36 |
| 2008-09-20 | @ CHN | 154 | L 4-5 | 80-74 | 4 | 41,597 | Joel Pineiro | Ted Lilly | Ted Lilly | Joel Pineiro | Kerry Wood | 727 | 692 | 35 |
| 2008-09-21 | @ CHN | 155 | L 1-5 | 80-75 | 4 | 40,551 | Braden Looper | Ryan Dempster | Ryan Dempster | Braden Looper | | 728 | 697 | 31 |
| 2008-09-22 | vs ARI | 156 | L 2-4 | 80-76 | 4 | 40,349 | Todd Wellemeyer | Brandon Webb | Brandon Webb | Todd Wellemeyer | Chad Qualls | 730 | 701 | 29 |
| 2008-09-23 | vs ARI | 157 | W 7-4 | 81-76 | 4 | 40,013 | Kyle Lohse | Randy Johnson | Kyle Lohse | Randy Johnson | Ryan Franklin | 737 | 705 | 32 |
| 2008-09-24 | vs ARI | 158 | W 4-2 | 82-76 | 4 | 40,029 | Adam Wainwright | Max Scherzer | Adam Wainwright | Max Scherzer | Ryan Franklin | 741 | 707 | 34 |
| 2008-09-25 | vs ARI | 159 | W 12-3 | 83-76 | 4 | 40,502 | Joel Pineiro | Doug Davis | Joel Pineiro | Leo Rosales | | 753 | 710 | 43 |
| 2008-09-26 | vs CIN | 160 | W 7-6 | 84-76 | 4 | 44,709 | Braden Looper | Bronson Arroyo | Ryan Franklin | Bill Bray | | 760 | 716 | 44 |
| 2008-09-27 | vs CIN | 161 | W 8-5 | 85-76 | 4 | 43,682 | Todd Wellemeyer | Aaron Harang | Todd Wellemeyer | Aaron Harang | | 768 | 721 | 47 |
| 2008-09-28 | vs CIN | 162 | W 11-4 | 86-76 | 4 | 43,300 | Brad Thompson | Adam Pettyjohn | Brad Thompson | Adam Pettyjohn | | 779 | 725 | 54 |