| 2008-03-31 | @ LAN | 1 | L 0-5 | 0-1 | 5 | 56,000 | Barry Zito | Brad Penny | Brad Penny | Barry Zito | | 0 | 5 | -5 |
| 2008-04-01 | @ LAN | 2 | L 2-3 | 0-2 | 5 | 44,054 | Matt Cain | Derek Lowe | Takashi Saito | Keiichi Yabu | | 2 | 8 | -6 |
| 2008-04-02 | @ LAN | 3 | W 2-1 | 1-2 | 5 | 43,217 | Merkin Valdez | Hong-Chih Kuo | Tim Lincecum | Esteban Loaiza | Brian Wilson | 4 | 9 | -5 |
| 2008-04-04 | @ MIL | 4 | L 4-13 | 1-3 | 5 | 45,212 | Jonathan Sanchez | Carlos Villanueva | Carlos Villanueva | Jonathan Sanchez | Salomon Torres | 8 | 22 | -14 |
| 2008-04-05 | @ MIL | 5 | L 4-5 | 1-4 | 5 | 30,574 | Kevin Correia | Manny Parra | Manny Parra | Kevin Correia | Eric Gagne | 12 | 27 | -15 |
| 2008-04-06 | @ MIL | 6 | L 0-7 | 1-5 | 5 | 44,014 | Barry Zito | Ben Sheets | Ben Sheets | Barry Zito | | 12 | 34 | -22 |
| 2008-04-07 | vs SDN | 7 | L 4-8 | 1-6 | 5 | 42,861 | Matt Cain | Greg Maddux | Greg Maddux | Matt Cain | | 16 | 42 | -26 |
| 2008-04-08 | vs SDN | 8 | W 3-2 | 2-6 | 5 | 35,795 | Tim Lincecum | Randy Wolf | Brad Hennessey | Cla Meredith | | 19 | 44 | -25 |
| 2008-04-09 | vs SDN | 9 | W 1-0 | 3-6 | 5 | 30,310 | Jonathan Sanchez | Justin Germano | Tyler Walker | Heath Bell | | 20 | 44 | -24 |
| 2008-04-10 | vs SLN | 10 | W 5-1 | 4-6 | 5 | 30,333 | Kevin Correia | Adam Wainwright | Kevin Correia | Adam Wainwright | Brian Wilson | 25 | 45 | -20 |
| 2008-04-11 | vs SLN | 11 | L 2-8 | 4-7 | 5 | 33,954 | Barry Zito | Kyle Lohse | Kyle Lohse | Barry Zito | | 27 | 53 | -26 |
| 2008-04-12 | vs SLN | 12 | L 7-8 | 4-8 | 5 | 35,717 | Matt Cain | Todd Wellemeyer | Jason Isringhausen | Erick Threets | Anthony Reyes | 34 | 61 | -27 |
| 2008-04-13 | vs SLN | 13 | W 7-4 | 5-8 | 5 | 37,195 | Tim Lincecum | Joel Pineiro | Tim Lincecum | Joel Pineiro | Brian Wilson | 41 | 65 | -24 |
| 2008-04-14 | vs ARI | 14 | W 5-4 | 6-8 | 3 | 30,371 | Jonathan Sanchez | Randy Johnson | Keiichi Yabu | Chad Qualls | Brian Wilson | 46 | 69 | -23 |
| 2008-04-15 | vs ARI | 15 | L 2-8 | 6-9 | 4 | 30,068 | Kevin Correia | Micah Owings | Micah Owings | Kevin Correia | | 48 | 77 | -29 |
| 2008-04-16 | vs ARI | 16 | L 1-4 | 6-10 | 5 | 30,510 | Barry Zito | Brandon Webb | Brandon Webb | Barry Zito | Brandon Lyon | 49 | 81 | -32 |
| 2008-04-18 | @ SLN | 17 | L 1-11 | 6-11 | 5 | 40,684 | Matt Cain | Todd Wellemeyer | Todd Wellemeyer | Matt Cain | | 50 | 92 | -42 |
| 2008-04-19 | @ SLN | 18 | W 3-0 | 7-11 | 5 | 41,707 | Tim Lincecum | Joel Pineiro | Tim Lincecum | Joel Pineiro | Brian Wilson | 53 | 92 | -39 |
| 2008-04-20 | @ SLN | 19 | W 8-2 | 8-11 | 4 | 41,127 | Jonathan Sanchez | Braden Looper | Jonathan Sanchez | Braden Looper | | 61 | 94 | -33 |
| 2008-04-21 | @ ARI | 20 | L 2-4 | 8-12 | 5 | 22,097 | Kevin Correia | Micah Owings | Micah Owings | Kevin Correia | Brandon Lyon | 63 | 98 | -35 |
| 2008-04-22 | @ ARI | 21 | L 4-5 | 8-13 | 5 | 25,074 | Barry Zito | Brandon Webb | Brandon Webb | Barry Zito | Brandon Lyon | 67 | 103 | -36 |
| 2008-04-23 | @ SDN | 22 | W 3-2 | 9-13 | 5 | 25,506 | Matt Cain | Greg Maddux | Keiichi Yabu | Glendon Rusch | Brian Wilson | 70 | 105 | -35 |
| 2008-04-24 | @ SDN | 23 | W 1-0 | 10-13 | 3 | 26,789 | Tim Lincecum | Chris Young | Tim Lincecum | Chris Young | Brian Wilson | 71 | 105 | -34 |
| 2008-04-25 | vs CIN | 24 | W 3-1 | 11-13 | 2 | 34,657 | Jonathan Sanchez | Aaron Harang | Jonathan Sanchez | Aaron Harang | Brian Wilson | 74 | 106 | -32 |
| 2008-04-26 | vs CIN | 25 | L 9-10 | 11-14 | 3 | 34,215 | Kevin Correia | Matt Belisle | Matt Belisle | Brad Hennessey | Francisco Cordero | 83 | 116 | -33 |
| 2008-04-27 | vs CIN | 26 | L 1-10 | 11-15 | 3 | 39,050 | Barry Zito | Edinson Volquez | Edinson Volquez | Barry Zito | | 84 | 126 | -42 |
| 2008-04-28 | vs COL | 27 | W 4-0 | 12-15 | 3 | 30,153 | Matt Cain | Franklin Morales | Matt Cain | Franklin Morales | | 88 | 126 | -38 |
| 2008-04-29 | vs COL | 28 | L 2-3 | 12-16 | 3 | 32,176 | Tim Lincecum | Aaron Cook | Aaron Cook | Tim Lincecum | Brian Fuentes | 90 | 129 | -39 |
| 2008-04-30 | vs COL | 29 | W 3-2 | 13-16 | 3 | 30,509 | Jonathan Sanchez | Ubaldo Jimenez | Merkin Valdez | Ryan Speier | Brian Wilson | 93 | 131 | -38 |
| 2008-05-02 | @ PHI | 30 | L 5-6 | 13-17 | 3 | 38,270 | Pat Misch | Kyle Kendrick | J.C. Romero | Brian Wilson | | 98 | 137 | -39 |
| 2008-05-03 | @ PHI | 31 | W 3-2 | 14-17 | 3 | 43,804 | Matt Cain | Brett Myers | Jack Taschner | Rudy Seanez | Brian Wilson | 101 | 139 | -38 |
| 2008-05-04 | @ PHI | 32 | L 5-6 | 14-18 | 3 | 45,110 | Tim Lincecum | Cole Hamels | Brad Lidge | Keiichi Yabu | | 106 | 145 | -39 |
| 2008-05-06 | @ PIT | 33 | L 6-12 | 14-19 | 3 | 12,030 | Jonathan Sanchez | Zach Duke | Zach Duke | Jonathan Sanchez | | 112 | 157 | -45 |
| 2008-05-07 | @ PIT | 34 | L 1-3 | 14-20 | 3 | 9,788 | Barry Zito | Phil Dumatrait | Phil Dumatrait | Barry Zito | Matt Capps | 113 | 160 | -47 |
| 2008-05-08 | @ PIT | 35 | L 4-5 | 14-21 | 4 | 16,816 | Matt Cain | Paul Maholm | Franquelis Osoria | Matt Cain | Matt Capps | 117 | 165 | -48 |
| 2008-05-09 | vs PHI | 36 | L 4-7 | 14-22 | 4 | 33,796 | Pat Misch | Cole Hamels | Cole Hamels | Tyler Walker | Brad Lidge | 121 | 172 | -51 |
| 2008-05-10 | vs PHI | 37 | W 8-2 | 15-22 | 4 | 34,064 | Tim Lincecum | Jamie Moyer | Tim Lincecum | Jamie Moyer | | 129 | 174 | -45 |
| 2008-05-11 | vs PHI | 38 | W 4-3 | 16-22 | 3 | 35,999 | Jonathan Sanchez | Adam Eaton | Jack Taschner | J.C. Romero | Brian Wilson | 133 | 177 | -44 |
| 2008-05-12 | vs HOU | 39 | L 3-7 | 16-23 | 3 | 30,165 | Barry Zito | Roy Oswalt | Roy Oswalt | Vinnie Chulk | Jose Valverde | 136 | 184 | -48 |
| 2008-05-13 | vs HOU | 40 | W 4-2 | 17-23 | 3 | 30,858 | Matt Cain | Brandon Backe | Matt Cain | Brandon Backe | Brian Wilson | 140 | 186 | -46 |
| 2008-05-14 | vs HOU | 41 | L 3-6 | 17-24 | 3 | 33,070 | Pat Misch | Brian Moehler | Oscar Villarreal | Jack Taschner | Jose Valverde | 143 | 192 | -49 |
| 2008-05-15 | vs HOU | 42 | L 7-8 | 17-25 | 3 | 33,771 | Tim Lincecum | Chris Sampson | Tim Byrdak | Vinnie Chulk | Jose Valverde | 150 | 200 | -50 |
| 2008-05-16 | vs CHA | 43 | L 0-2 | 17-26 | 3 | 35,482 | Jonathan Sanchez | Gavin Floyd | Gavin Floyd | Jonathan Sanchez | Bobby Jenks | 150 | 202 | -52 |
| 2008-05-17 | vs CHA | 44 | L 1-3 | 17-27 | 3 | 37,006 | Barry Zito | Mark Buehrle | Mark Buehrle | Barry Zito | Bobby Jenks | 151 | 205 | -54 |
| 2008-05-18 | vs CHA | 45 | L 8-13 | 17-28 | 4 | 34,331 | Matt Cain | John Danks | Matt Thornton | Tyler Walker | Nick Masset | 159 | 218 | -59 |
| 2008-05-19 | @ COL | 46 | L 3-4 | 17-29 | 4 | 28,362 | Pat Misch | Jorge de la Rosa | Jason Grilli | Vinnie Chulk | Brian Fuentes | 162 | 222 | -60 |
| 2008-05-20 | @ COL | 47 | W 6-5 | 18-29 | 4 | 28,361 | Tim Lincecum | Aaron Cook | Tim Lincecum | Aaron Cook | Brian Wilson | 168 | 227 | -59 |
| 2008-05-21 | @ COL | 48 | W 3-2 | 19-29 | 3 | 27,081 | Jonathan Sanchez | Ubaldo Jimenez | Tyler Walker | Matt Herges | Brian Wilson | 171 | 229 | -58 |
| 2008-05-23 | @ FLO | 49 | W 8-2 | 20-29 | 3 | 15,003 | Barry Zito | Scott Olsen | Barry Zito | Scott Olsen | | 179 | 231 | -52 |
| 2008-05-25 | @ FLO | 50 | L 6-8 | 20-31 | 4 | 0 | Pat Misch | Mark Hendrickson | Mark Hendrickson | Pat Misch | Kevin Gregg | 185 | 239 | -54 |
| 2008-05-25 | @ FLO | 51 | L 4-5 | 20-31 | 4 | 14,674 | Matt Cain | Eulogio de la Cruz | Kevin Gregg | Tyler Walker | | 189 | 244 | -55 |
| 2008-05-27 | @ ARI | 52 | W 6-3 | 21-31 | 3 | 23,604 | Tim Lincecum | Dan Haren | Tim Lincecum | Dan Haren | Brian Wilson | 195 | 247 | -52 |
| 2008-05-28 | @ ARI | 53 | W 11-3 | 22-31 | 3 | 24,336 | Jonathan Sanchez | Doug Davis | Jonathan Sanchez | Doug Davis | | 206 | 250 | -44 |
| 2008-05-29 | @ ARI | 54 | W 4-3 | 23-31 | 3 | 21,037 | Barry Zito | Randy Johnson | Tyler Walker | Chad Qualls | Brian Wilson | 210 | 253 | -43 |
| 2008-05-30 | vs SDN | 55 | L 3-7 | 23-32 | 3 | 37,178 | Matt Cain | Greg Maddux | Cha-Seung Baek | Billy Sadler | | 213 | 260 | -47 |
| 2008-05-31 | vs SDN | 56 | L 1-5 | 23-33 | 3 | 34,921 | Pat Misch | Josh Banks | Josh Banks | Pat Misch | | 214 | 265 | -51 |
| 2008-06-01 | vs SDN | 57 | W 4-3 | 24-33 | 3 | 33,867 | Tim Lincecum | Randy Wolf | Alex Hinshaw | Trevor Hoffman | | 218 | 268 | -50 |
| 2008-06-02 | vs NYN | 58 | W 10-2 | 25-33 | 3 | 36,126 | Jonathan Sanchez | Oliver Perez | Jonathan Sanchez | Oliver Perez | | 228 | 270 | -42 |
| 2008-06-03 | vs NYN | 59 | L 6-9 | 25-34 | 3 | 35,233 | Barry Zito | Pedro Martinez | Pedro Martinez | Barry Zito | Billy Wagner | 234 | 279 | -45 |
| 2008-06-04 | vs NYN | 60 | L 3-5 | 25-35 | 3 | 35,646 | Matt Cain | John Maine | John Maine | Matt Cain | Billy Wagner | 237 | 284 | -47 |
| 2008-06-06 | @ WAS | 61 | W 10-1 | 26-35 | 3 | 25,987 | Tim Lincecum | Jason Bergmann | Tim Lincecum | Jason Bergmann | | 247 | 285 | -38 |
| 2008-06-07 | @ WAS | 62 | W 6-0 | 27-35 | 3 | 30,652 | Jonathan Sanchez | Shawn Hill | Jonathan Sanchez | Shawn Hill | | 253 | 285 | -32 |
| 2008-06-08 | @ WAS | 63 | W 6-3 | 28-35 | 3 | 30,224 | Barry Zito | Garrett Mock | Barry Zito | Garrett Mock | Brian Wilson | 259 | 288 | -29 |
| 2008-06-09 | @ WAS | 64 | W 3-2 | 29-35 | 3 | 26,209 | Matt Cain | Tyler Clippard | Matt Cain | Tyler Clippard | Brian Wilson | 262 | 290 | -28 |
| 2008-06-10 | @ COL | 65 | L 5-10 | 29-36 | 3 | 28,359 | Pat Misch | Aaron Cook | Aaron Cook | Pat Misch | | 267 | 300 | -33 |
| 2008-06-11 | @ COL | 66 | L 0-1 | 29-37 | 3 | 26,235 | Tim Lincecum | Ubaldo Jimenez | Brian Fuentes | Keiichi Yabu | | 267 | 301 | -34 |
| 2008-06-12 | @ COL | 67 | W 10-7 | 30-37 | 3 | 30,376 | Jonathan Sanchez | Greg Reynolds | Jonathan Sanchez | Greg Reynolds | Brian Wilson | 277 | 308 | -31 |
| 2008-06-13 | vs OAK | 68 | L 1-5 | 30-38 | 3 | 42,445 | Barry Zito | Greg Smith | Greg Smith | Barry Zito | | 278 | 313 | -35 |
| 2008-06-14 | vs OAK | 69 | L 0-4 | 30-39 | 4 | 40,873 | Matt Cain | Rich Harden | Rich Harden | Matt Cain | | 278 | 317 | -39 |
| 2008-06-15 | vs OAK | 70 | L 3-5 | 30-40 | 4 | 41,547 | Kevin Correia | Dana Eveland | Dana Eveland | Kevin Correia | Huston Street | 281 | 322 | -41 |
| 2008-06-16 | vs DET | 71 | W 8-6 | 31-40 | 4 | 33,317 | Tim Lincecum | Justin Verlander | Keiichi Yabu | Freddy Dolsi | | 289 | 328 | -39 |
| 2008-06-17 | vs DET | 72 | L 1-5 | 31-41 | 4 | 33,636 | Jonathan Sanchez | Kenny Rogers | Kenny Rogers | Jonathan Sanchez | | 290 | 333 | -43 |
| 2008-06-18 | vs DET | 73 | L 2-7 | 31-42 | 4 | 38,194 | Barry Zito | Armando Galarraga | Armando Galarraga | Barry Zito | | 292 | 340 | -48 |
| 2008-06-20 | @ KCA | 74 | W 9-4 | 32-42 | 3 | 34,588 | Matt Cain | Luke Hochevar | Matt Cain | Yasuhiko Yabuta | | 301 | 344 | -43 |
| 2008-06-21 | @ KCA | 75 | L 3-5 | 32-43 | 4 | 28,903 | Kevin Correia | Gil Meche | Gil Meche | Kevin Correia | Joakim Soria | 304 | 349 | -45 |
| 2008-06-22 | @ KCA | 76 | L 10-11 | 32-44 | 4 | 20,499 | Tim Lincecum | Kyle Davies | Ron Mahay | Alex Hinshaw | Joakim Soria | 314 | 360 | -46 |
| 2008-06-24 | @ CLE | 77 | W 3-2 | 33-44 | 3 | 29,024 | Jonathan Sanchez | Aaron Laffey | Jonathan Sanchez | Rafael Betancourt | Brian Wilson | 317 | 362 | -45 |
| 2008-06-25 | @ CLE | 78 | W 4-1 | 34-44 | 3 | 25,654 | Barry Zito | Jeremy Sowers | Barry Zito | Jeremy Sowers | Brian Wilson | 321 | 363 | -42 |
| 2008-06-26 | @ CLE | 79 | L 1-4 | 34-45 | 3 | 25,257 | Matt Cain | Cliff Lee | Cliff Lee | Matt Cain | Joe Borowski | 322 | 367 | -45 |
| 2008-06-27 | @ OAK | 80 | L 1-4 | 34-46 | 3 | 27,125 | Kevin Correia | Dana Eveland | Dana Eveland | Keiichi Yabu | Huston Street | 323 | 371 | -48 |
| 2008-06-28 | @ OAK | 81 | W 1-0 | 35-46 | 3 | 36,067 | Tim Lincecum | Justin Duchscherer | Tim Lincecum | Justin Duchscherer | Brian Wilson | 324 | 371 | -47 |
| 2008-06-29 | @ OAK | 82 | W 11-1 | 36-46 | 3 | 33,841 | Jonathan Sanchez | Joe Blanton | Jonathan Sanchez | Joe Blanton | | 335 | 372 | -37 |
| 2008-06-30 | vs CHN | 83 | L 2-9 | 36-47 | 3 | 35,311 | Barry Zito | Ted Lilly | Ted Lilly | Barry Zito | | 337 | 381 | -44 |
| 2008-07-01 | vs CHN | 84 | W 2-1 | 37-47 | 3 | 33,858 | Matt Cain | Jason Marquis | Matt Cain | Jason Marquis | Brian Wilson | 339 | 382 | -43 |
| 2008-07-02 | vs CHN | 85 | L 5-6 | 37-48 | 3 | 41,345 | Kevin Correia | Ryan Dempster | Carlos Marmol | Tyler Walker | Kerry Wood | 344 | 388 | -44 |
| 2008-07-03 | vs CHN | 86 | W 8-3 | 38-48 | 3 | 40,511 | Tim Lincecum | Sean Gallagher | Tim Lincecum | Sean Gallagher | | 352 | 391 | -39 |
| 2008-07-04 | vs LAN | 87 | L 7-10 | 38-49 | 3 | 40,447 | Jonathan Sanchez | Derek Lowe | Derek Lowe | Osiris Matos | Takashi Saito | 359 | 401 | -42 |
| 2008-07-05 | vs LAN | 88 | W 5-2 | 39-49 | 3 | 40,741 | Barry Zito | Chan Ho Park | Barry Zito | Brian Falkenborg | Brian Wilson | 364 | 403 | -39 |
| 2008-07-06 | vs LAN | 89 | L 3-5 | 39-50 | 3 | 38,290 | Matt Cain | Eric Stults | Brian Falkenborg | Matt Cain | Takashi Saito | 367 | 408 | -41 |
| 2008-07-08 | @ NYN | 90 | L 0-7 | 39-51 | 3 | 48,887 | Tim Lincecum | Mike Pelfrey | Mike Pelfrey | Tim Lincecum | | 367 | 415 | -48 |
| 2008-07-09 | @ NYN | 91 | L 0-5 | 39-52 | 3 | 48,896 | Jonathan Sanchez | Johan Santana | Johan Santana | Jonathan Sanchez | | 367 | 420 | -53 |
| 2008-07-10 | @ NYN | 92 | L 3-7 | 39-53 | 3 | 48,755 | Barry Zito | John Maine | Scott Schoeneweis | Sergio Romo | | 370 | 427 | -57 |
| 2008-07-11 | @ CHN | 93 | L 1-3 | 39-54 | 3 | 41,605 | Matt Cain | Jason Marquis | Bob Howry | Tyler Walker | Kerry Wood | 371 | 430 | -59 |
| 2008-07-12 | @ CHN | 94 | L 7-8 | 39-55 | 3 | 41,555 | Kevin Correia | Rich Harden | Sean Marshall | Brian Wilson | | 378 | 438 | -60 |
| 2008-07-13 | @ CHN | 95 | W 4-2 | 40-55 | 3 | 41,574 | Tim Lincecum | Ryan Dempster | Tim Lincecum | Ryan Dempster | Brian Wilson | 382 | 440 | -58 |
| 2008-07-18 | vs MIL | 96 | L 1-9 | 40-56 | 4 | 40,882 | Matt Cain | CC Sabathia | CC Sabathia | Matt Cain | | 383 | 449 | -66 |
| 2008-07-19 | vs MIL | 97 | L 5-8 | 40-57 | 4 | 36,852 | Jonathan Sanchez | Ben Sheets | Carlos Villanueva | Osiris Matos | Salomon Torres | 388 | 457 | -69 |
| 2008-07-20 | vs MIL | 98 | L 4-7 | 40-58 | 4 | 37,507 | Tim Lincecum | Manny Parra | Manny Parra | Tim Lincecum | Salomon Torres | 392 | 464 | -72 |
| 2008-07-22 | vs WAS | 99 | W 6-3 | 41-58 | 4 | 34,813 | Barry Zito | Jason Bergmann | Barry Zito | Jason Bergmann | Brian Wilson | 398 | 467 | -69 |
| 2008-07-23 | vs WAS | 100 | W 6-4 | 42-58 | 4 | 35,539 | Kevin Correia | Collin Balester | Geno Espineli | Luis Ayala | Brian Wilson | 404 | 471 | -67 |
| 2008-07-24 | vs WAS | 101 | W 1-0 | 43-58 | 4 | 36,963 | Matt Cain | Tim Redding | Matt Cain | Tim Redding | | 405 | 471 | -66 |
| 2008-07-25 | vs ARI | 102 | L 2-10 | 43-59 | 4 | 32,851 | Jonathan Sanchez | Dan Haren | Dan Haren | Jonathan Sanchez | | 407 | 481 | -74 |
| 2008-07-26 | vs ARI | 103 | L 3-5 | 43-60 | 4 | 37,094 | Tim Lincecum | Brandon Webb | Brandon Webb | Tyler Walker | Brandon Lyon | 410 | 486 | -76 |
| 2008-07-27 | vs ARI | 104 | L 2-7 | 43-61 | 4 | 40,071 | Barry Zito | Randy Johnson | Randy Johnson | Barry Zito | | 412 | 493 | -81 |
| 2008-07-28 | @ LAN | 105 | W 7-6 | 44-61 | 4 | 37,483 | Kevin Correia | Hiroki Kuroda | Kevin Correia | Hiroki Kuroda | Brian Wilson | 419 | 499 | -80 |
| 2008-07-29 | @ LAN | 106 | L 0-2 | 44-62 | 4 | 40,110 | Matt Cain | Jason Johnson | Jason Johnson | Matt Cain | Jonathan Broxton | 419 | 501 | -82 |
| 2008-07-30 | @ LAN | 107 | L 0-4 | 44-63 | 4 | 41,282 | Jonathan Sanchez | Chad Billingsley | Chad Billingsley | Jonathan Sanchez | | 419 | 505 | -86 |
| 2008-08-01 | @ SDN | 108 | W 3-2 | 45-63 | 4 | 33,926 | Tim Lincecum | Josh Banks | Sergio Romo | Trevor Hoffman | Brian Wilson | 422 | 507 | -85 |
| 2008-08-02 | @ SDN | 109 | W 2-0 | 46-63 | 4 | 41,688 | Barry Zito | Jake Peavy | Barry Zito | Jake Peavy | Brian Wilson | 424 | 507 | -83 |
| 2008-08-03 | @ SDN | 110 | L 1-4 | 46-64 | 4 | 33,060 | Kevin Correia | Greg Maddux | Greg Maddux | Kevin Correia | Trevor Hoffman | 425 | 511 | -86 |
| 2008-08-04 | vs ATL | 111 | W 4-2 | 47-64 | 4 | 37,473 | Matt Cain | Jair Jurrjens | Matt Cain | Jair Jurrjens | Brian Wilson | 429 | 513 | -84 |
| 2008-08-05 | vs ATL | 112 | L 4-11 | 47-65 | 4 | 36,098 | Jonathan Sanchez | Mike Hampton | Mike Hampton | Jonathan Sanchez | | 433 | 524 | -91 |
| 2008-08-06 | vs ATL | 113 | W 3-2 | 48-65 | 4 | 39,955 | Tim Lincecum | Chuck James | Tim Lincecum | Chuck James | Brian Wilson | 436 | 526 | -90 |
| 2008-08-08 | vs LAN | 114 | L 2-6 | 48-66 | 4 | 40,142 | Barry Zito | Brad Penny | Brad Penny | Barry Zito | Jonathan Broxton | 438 | 532 | -94 |
| 2008-08-09 | vs LAN | 115 | W 3-2 | 49-66 | 4 | 41,963 | Kevin Correia | Hiroki Kuroda | Tyler Walker | Jonathan Broxton | | 441 | 534 | -93 |
| 2008-08-10 | vs LAN | 116 | W 5-4 | 50-66 | 4 | 41,804 | Matt Cain | Chad Billingsley | Jack Taschner | Hong-Chih Kuo | | 446 | 538 | -92 |
| 2008-08-11 | @ HOU | 117 | L 1-3 | 50-67 | 4 | 28,220 | Jonathan Sanchez | Brandon Backe | Brandon Backe | Jonathan Sanchez | Jose Valverde | 447 | 541 | -94 |
| 2008-08-12 | @ HOU | 118 | L 4-12 | 50-68 | 4 | 29,451 | Tim Lincecum | Roy Oswalt | Roy Oswalt | Tyler Walker | | 451 | 553 | -102 |
| 2008-08-13 | @ HOU | 119 | L 2-6 | 50-69 | 4 | 30,330 | Barry Zito | Randy Wolf | Randy Wolf | Barry Zito | | 453 | 559 | -106 |
| 2008-08-14 | @ HOU | 120 | L 4-7 | 50-70 | 4 | 33,612 | Kevin Correia | Brian Moehler | LaTroy Hawkins | Keiichi Yabu | Jose Valverde | 457 | 566 | -109 |
| 2008-08-15 | @ ATL | 121 | W 5-1 | 51-70 | 4 | 30,682 | Matt Cain | Jair Jurrjens | Matt Cain | Jair Jurrjens | | 462 | 567 | -105 |
| 2008-08-16 | @ ATL | 122 | L 5-11 | 51-71 | 4 | 41,893 | Matt Palmer | Mike Hampton | Mike Hampton | Matt Palmer | | 467 | 578 | -111 |
| 2008-08-17 | @ ATL | 123 | W 3-1 | 52-71 | 4 | 30,503 | Tim Lincecum | Charlie Morton | Tim Lincecum | Charlie Morton | Brian Wilson | 470 | 579 | -109 |
| 2008-08-18 | @ ATL | 124 | W 5-0 | 53-71 | 4 | 18,113 | Barry Zito | Jorge Campillo | Barry Zito | Jorge Campillo | | 475 | 579 | -104 |
| 2008-08-19 | vs FLO | 125 | L 0-6 | 53-72 | 4 | 33,098 | Kevin Correia | Ricky Nolasco | Ricky Nolasco | Kevin Correia | | 475 | 585 | -110 |
| 2008-08-20 | vs FLO | 126 | W 6-5 | 54-72 | 4 | 30,399 | Matt Cain | Scott Olsen | Brian Wilson | Matt Lindstrom | | 481 | 590 | -109 |
| 2008-08-21 | vs FLO | 127 | W 4-3 | 55-72 | 4 | 32,515 | Matt Palmer | Josh Johnson | Brian Wilson | Kevin Gregg | | 485 | 593 | -108 |
| 2008-08-22 | vs SDN | 128 | W 5-0 | 56-72 | 4 | 33,615 | Tim Lincecum | Cha-Seung Baek | Tim Lincecum | Cha-Seung Baek | | 490 | 593 | -103 |
| 2008-08-23 | vs SDN | 129 | W 4-3 | 57-72 | 4 | 37,081 | Barry Zito | Dirk Hayhurst | Barry Zito | Mike Adams | Brian Wilson | 494 | 596 | -102 |
| 2008-08-24 | vs SDN | 130 | W 7-4 | 58-72 | 4 | 37,174 | Kevin Correia | Josh Banks | Kevin Correia | Mike Adams | Brian Wilson | 501 | 600 | -99 |
| 2008-08-25 | vs COL | 131 | L 2-4 | 58-73 | 4 | 31,132 | Matt Cain | Jeff Francis | Jeff Francis | Matt Cain | Brian Fuentes | 503 | 604 | -101 |
| 2008-08-26 | vs COL | 132 | L 2-7 | 58-74 | 4 | 32,695 | Matt Palmer | Jorge de la Rosa | Jorge de la Rosa | Matt Palmer | Jason Grilli | 505 | 611 | -106 |
| 2008-08-27 | vs COL | 133 | W 4-1 | 59-74 | 4 | 31,627 | Tim Lincecum | Livan Hernandez | Tim Lincecum | Livan Hernandez | Brian Wilson | 509 | 612 | -103 |
| 2008-08-29 | @ CIN | 134 | L 7-11 | 59-75 | 4 | 25,445 | Barry Zito | Edinson Volquez | Edinson Volquez | Barry Zito | | 516 | 623 | -107 |
| 2008-08-30 | @ CIN | 135 | L 6-7 | 59-76 | 4 | 21,729 | Kevin Correia | Ramon Ramirez | Mike Lincoln | Jack Taschner | Francisco Cordero | 522 | 630 | -108 |
| 2008-08-31 | @ CIN | 136 | L 3-9 | 59-77 | 4 | 26,519 | Matt Cain | Bronson Arroyo | Bronson Arroyo | Matt Cain | | 525 | 639 | -114 |
| 2008-09-01 | @ COL | 137 | L 0-4 | 59-78 | 4 | 31,388 | Jonathan Sanchez | Jorge de la Rosa | Jorge de la Rosa | Jonathan Sanchez | | 525 | 643 | -118 |
| 2008-09-02 | @ COL | 138 | L 5-6 | 59-79 | 4 | 23,710 | Tim Lincecum | Livan Hernandez | Jason Grilli | Keiichi Yabu | | 530 | 649 | -119 |
| 2008-09-03 | @ COL | 139 | W 9-2 | 60-79 | 4 | 23,481 | Barry Zito | Aaron Cook | Barry Zito | Aaron Cook | | 539 | 651 | -112 |
| 2008-09-05 | vs PIT | 140 | L 0-7 | 60-80 | 4 | 31,133 | Kevin Correia | Zach Duke | Zach Duke | Kevin Correia | | 539 | 658 | -119 |
| 2008-09-06 | vs PIT | 141 | W 7-6 | 61-80 | 4 | 38,094 | Matt Cain | Paul Maholm | Geno Espineli | Denny Bautista | Brian Wilson | 546 | 664 | -118 |
| 2008-09-07 | vs PIT | 142 | W 11-6 | 62-80 | 4 | 34,122 | Jonathan Sanchez | Jeff Karstens | Osiris Matos | Jeff Karstens | | 557 | 670 | -113 |
| 2008-09-08 | vs ARI | 143 | W 6-2 | 63-80 | 4 | 30,252 | Tim Lincecum | Yusmeiro Petit | Tim Lincecum | Yusmeiro Petit | | 563 | 672 | -109 |
| 2008-09-09 | vs ARI | 144 | W 5-4 | 64-80 | 4 | 30,518 | Barry Zito | Doug Davis | Brian Wilson | Jon Rauch | | 568 | 676 | -108 |
| 2008-09-10 | vs ARI | 145 | W 4-3 | 65-80 | 4 | 30,992 | Brad Hennessey | Dan Haren | Alex Hinshaw | Brandon Lyon | | 572 | 679 | -107 |
| 2008-09-11 | @ SDN | 146 | L 3-11 | 65-81 | 4 | 30,497 | Matt Cain | Josh Geer | Josh Geer | Matt Cain | | 575 | 690 | -115 |
| 2008-09-12 | @ SDN | 147 | W 5-2 | 66-81 | 4 | 24,610 | Jonathan Sanchez | Jake Peavy | Jonathan Sanchez | Jake Peavy | Brian Wilson | 580 | 692 | -112 |
| 2008-09-13 | @ SDN | 148 | W 7-0 | 67-81 | 3 | 31,015 | Tim Lincecum | Chris Young | Tim Lincecum | Chris Young | | 587 | 692 | -105 |
| 2008-09-14 | @ SDN | 149 | W 8-6 | 68-81 | 3 | 25,476 | Barry Zito | Cha-Seung Baek | Sergio Romo | Dirk Hayhurst | Brian Wilson | 595 | 698 | -103 |
| 2008-09-15 | @ ARI | 150 | L 1-3 | 68-82 | 3 | 25,969 | Brad Hennessey | Doug Davis | Tony Pena | Brad Hennessey | Chad Qualls | 596 | 701 | -105 |
| 2008-09-16 | @ ARI | 151 | L 0-2 | 68-83 | 4 | 33,195 | Matt Cain | Dan Haren | Dan Haren | Matt Cain | | 596 | 703 | -107 |
| 2008-09-17 | @ ARI | 152 | L 6-7 | 68-84 | 4 | 22,618 | Jonathan Sanchez | Brandon Webb | Brandon Webb | Jonathan Sanchez | Tony Pena | 602 | 710 | -108 |
| 2008-09-18 | @ ARI | 153 | L 2-3 | 68-85 | 4 | 34,323 | Tim Lincecum | Randy Johnson | Juan Cruz | Tim Lincecum | Chad Qualls | 604 | 713 | -109 |
| 2008-09-19 | @ LAN | 154 | W 7-1 | 69-85 | 4 | 55,589 | Barry Zito | Greg Maddux | Barry Zito | Greg Maddux | | 611 | 714 | -103 |
| 2008-09-20 | @ LAN | 155 | L 7-10 | 69-86 | 4 | 55,724 | Brad Hennessey | Hiroki Kuroda | Takashi Saito | Tyler Walker | | 618 | 724 | -106 |
| 2008-09-21 | @ LAN | 156 | W 1-0 | 70-86 | 4 | 55,294 | Matt Cain | Derek Lowe | Sergio Romo | Takashi Saito | Brian Wilson | 619 | 724 | -105 |
| 2008-09-23 | vs COL | 157 | L 4-9 | 70-87 | 4 | 33,922 | Tim Lincecum | Ubaldo Jimenez | Ubaldo Jimenez | Tim Lincecum | | 623 | 733 | -110 |
| 2008-09-24 | vs COL | 158 | L 6-15 | 70-88 | 4 | 31,942 | Jonathan Sanchez | Livan Hernandez | Livan Hernandez | Jonathan Sanchez | | 629 | 748 | -119 |
| 2008-09-25 | vs COL | 159 | L 1-3 | 70-89 | 4 | 31,857 | Barry Zito | Jorge de la Rosa | Jorge de la Rosa | Barry Zito | Brian Fuentes | 630 | 751 | -121 |
| 2008-09-26 | vs LAN | 160 | W 6-5 | 71-89 | 4 | 33,920 | Brad Hennessey | Derek Lowe | Tyler Walker | Jason Johnson | | 636 | 756 | -120 |
| 2008-09-27 | vs LAN | 161 | L 1-2 | 71-90 | 4 | 38,673 | Matt Cain | Greg Maddux | Greg Maddux | Matt Cain | Takashi Saito | 637 | 758 | -121 |
| 2008-09-28 | vs LAN | 162 | W 3-1 | 72-90 | 4 | 39,167 | Tim Lincecum | Hiroki Kuroda | Tim Lincecum | Chan Ho Park | Brian Wilson | 640 | 759 | -119 |