| 2008-03-31 | vs WAS | 1 | L 6-11 | 0-1 | 5 | 44,553 | Brett Myers | Matt Chico | Saul Rivera | Tom Gordon | | 6 | 11 | -5 |
| 2008-04-02 | vs WAS | 2 | L 0-1 | 0-2 | 5 | 44,986 | Cole Hamels | Tim Redding | Tim Redding | Cole Hamels | Jon Rauch | 6 | 12 | -6 |
| 2008-04-03 | vs WAS | 3 | W 8-7 | 1-2 | 4 | 25,831 | Jamie Moyer | Jason Bergmann | Clay Condrey | Jesus Colome | | 14 | 19 | -5 |
| 2008-04-04 | @ CIN | 4 | W 8-4 | 2-2 | 4 | 17,905 | Kyle Kendrick | Josh Fogg | Kyle Kendrick | Josh Fogg | | 22 | 23 | -1 |
| 2008-04-05 | @ CIN | 5 | L 3-4 | 2-3 | 5 | 23,069 | Adam Eaton | Aaron Harang | Francisco Cordero | Chad Durbin | | 25 | 27 | -2 |
| 2008-04-06 | @ CIN | 6 | L 2-8 | 2-4 | 5 | 26,566 | Brett Myers | Edinson Volquez | Edinson Volquez | Brett Myers | | 27 | 35 | -8 |
| 2008-04-07 | @ CIN | 7 | W 5-3 | 3-4 | 3 | 14,647 | Cole Hamels | Bronson Arroyo | Cole Hamels | Bronson Arroyo | Brad Lidge | 32 | 38 | -6 |
| 2008-04-08 | @ NYN | 8 | W 5-2 | 4-4 | 2 | 56,350 | Jamie Moyer | Oliver Perez | Jamie Moyer | Scott Schoeneweis | Tom Gordon | 37 | 40 | -3 |
| 2008-04-09 | @ NYN | 9 | L 2-8 | 4-5 | 2 | 47,127 | Kyle Kendrick | Mike Pelfrey | Mike Pelfrey | Kyle Kendrick | | 39 | 48 | -9 |
| 2008-04-10 | @ NYN | 10 | L 3-4 | 4-6 | 3 | 49,045 | Adam Eaton | John Maine | Jorge Sosa | Tom Gordon | | 42 | 52 | -10 |
| 2008-04-11 | vs CHN | 11 | W 5-3 | 5-6 | 3 | 37,368 | Brett Myers | Carlos Zambrano | Brett Myers | Carlos Zambrano | Brad Lidge | 47 | 55 | -8 |
| 2008-04-12 | vs CHN | 12 | W 7-1 | 6-6 | 3 | 45,072 | Cole Hamels | Ted Lilly | Cole Hamels | Ted Lilly | | 54 | 56 | -2 |
| 2008-04-13 | vs CHN | 13 | L 5-6 | 6-7 | 2 | 40,095 | Jamie Moyer | Jason Marquis | Kerry Wood | Rudy Seanez | Bob Howry | 59 | 62 | -3 |
| 2008-04-15 | vs HOU | 14 | W 4-3 | 7-7 | 3 | 34,609 | Adam Eaton | Shawn Chacon | Rudy Seanez | Jose Valverde | | 63 | 65 | -2 |
| 2008-04-16 | vs HOU | 15 | L 1-2 | 7-8 | 3 | 31,644 | Kyle Kendrick | Roy Oswalt | Roy Oswalt | Kyle Kendrick | Doug Brocail | 64 | 67 | -3 |
| 2008-04-17 | vs HOU | 16 | W 10-2 | 8-8 | 3 | 33,526 | Brett Myers | Brandon Backe | Brett Myers | Brandon Backe | | 74 | 69 | 5 |
| 2008-04-18 | vs NYN | 17 | L 4-6 | 8-9 | 3 | 45,156 | Cole Hamels | Johan Santana | Johan Santana | Cole Hamels | Billy Wagner | 78 | 75 | 3 |
| 2008-04-19 | vs NYN | 18 | L 2-4 | 8-10 | 4 | 45,149 | Jamie Moyer | Oliver Perez | Oliver Perez | Jamie Moyer | Billy Wagner | 80 | 79 | 1 |
| 2008-04-20 | vs NYN | 19 | W 5-4 | 9-10 | 4 | 45,173 | Adam Eaton | Mike Pelfrey | J.C. Romero | Pedro Feliciano | Brad Lidge | 85 | 83 | 2 |
| 2008-04-21 | @ COL | 20 | W 9-5 | 10-10 | 4 | 24,886 | Kyle Kendrick | Mark Redman | Rudy Seanez | Taylor Buchholz | | 94 | 88 | 6 |
| 2008-04-22 | @ COL | 21 | W 8-6 | 11-10 | 3 | 26,665 | Brett Myers | Jeff Francis | Ryan Madson | Manuel Corpas | Brad Lidge | 102 | 94 | 8 |
| 2008-04-23 | @ MIL | 22 | L 4-5 | 11-11 | 3 | 30,548 | Cole Hamels | David Bush | Mitch Stetter | Cole Hamels | Derrick Turnbow | 106 | 99 | 7 |
| 2008-04-24 | @ MIL | 23 | W 3-1 | 12-11 | 3 | 23,905 | Jamie Moyer | Jeff Suppan | Tom Gordon | David Riske | Brad Lidge | 109 | 100 | 9 |
| 2008-04-25 | @ PIT | 24 | W 6-5 | 13-11 | 2 | 23,930 | Adam Eaton | Zach Duke | Tom Gordon | Zach Duke | Brad Lidge | 115 | 105 | 10 |
| 2008-04-26 | @ PIT | 25 | W 8-4 | 14-11 | 2 | 24,791 | Kyle Kendrick | Matt Morris | Kyle Kendrick | Matt Morris | | 123 | 109 | 14 |
| 2008-04-27 | @ PIT | 26 | L 1-5 | 14-12 | 3 | 17,588 | Brett Myers | Paul Maholm | Paul Maholm | Brett Myers | | 124 | 114 | 10 |
| 2008-04-29 | vs SDN | 27 | W 7-4 | 15-12 | 3 | 34,207 | Cole Hamels | Greg Maddux | Cole Hamels | Greg Maddux | | 131 | 118 | 13 |
| 2008-04-30 | vs SDN | 28 | L 2-4 | 15-13 | 3 | 36,648 | Jamie Moyer | Chris Young | Chris Young | Jamie Moyer | Trevor Hoffman | 133 | 122 | 11 |
| 2008-05-01 | vs SDN | 29 | W 3-2 | 16-13 | 1 | 33,001 | Adam Eaton | Randy Wolf | Tom Gordon | Joe Thatcher | Brad Lidge | 136 | 124 | 12 |
| 2008-05-02 | vs SFN | 30 | W 6-5 | 17-13 | 1 | 38,270 | Kyle Kendrick | Pat Misch | J.C. Romero | Brian Wilson | | 142 | 129 | 13 |
| 2008-05-03 | vs SFN | 31 | L 2-3 | 17-14 | 1 | 43,804 | Brett Myers | Matt Cain | Jack Taschner | Rudy Seanez | Brian Wilson | 144 | 132 | 12 |
| 2008-05-04 | vs SFN | 32 | W 6-5 | 18-14 | 1 | 45,110 | Cole Hamels | Tim Lincecum | Brad Lidge | Keiichi Yabu | | 150 | 137 | 13 |
| 2008-05-05 | @ ARI | 33 | W 11-4 | 19-14 | 1 | 21,266 | Jamie Moyer | Max Scherzer | Jamie Moyer | Max Scherzer | | 161 | 141 | 20 |
| 2008-05-06 | @ ARI | 34 | L 4-6 | 19-15 | 2 | 26,234 | Adam Eaton | Randy Johnson | Randy Johnson | Adam Eaton | Brandon Lyon | 165 | 147 | 18 |
| 2008-05-07 | @ ARI | 35 | W 5-4 | 20-15 | 2 | 21,260 | Kyle Kendrick | Micah Owings | J.C. Romero | Chad Qualls | Brad Lidge | 170 | 151 | 19 |
| 2008-05-08 | @ ARI | 36 | L 3-8 | 20-16 | 2 | 21,942 | Brett Myers | Brandon Webb | Brandon Webb | Brett Myers | | 173 | 159 | 14 |
| 2008-05-09 | @ SFN | 37 | W 7-4 | 21-16 | 2 | 33,796 | Cole Hamels | Pat Misch | Cole Hamels | Tyler Walker | Brad Lidge | 180 | 163 | 17 |
| 2008-05-10 | @ SFN | 38 | L 2-8 | 21-17 | 2 | 34,064 | Jamie Moyer | Tim Lincecum | Tim Lincecum | Jamie Moyer | | 182 | 171 | 11 |
| 2008-05-11 | @ SFN | 39 | L 3-4 | 21-18 | 3 | 35,999 | Adam Eaton | Jonathan Sanchez | Jack Taschner | J.C. Romero | Brian Wilson | 185 | 175 | 10 |
| 2008-05-13 | vs ATL | 40 | W 5-4 | 22-18 | 2 | 44,101 | Kyle Kendrick | Jo-Jo Reyes | Kyle Kendrick | Jo-Jo Reyes | Brad Lidge | 190 | 179 | 11 |
| 2008-05-14 | vs ATL | 41 | L 6-8 | 22-19 | 2 | 36,001 | Brett Myers | Tom Glavine | Tom Glavine | Brett Myers | Blaine Boyer | 196 | 187 | 9 |
| 2008-05-15 | vs ATL | 42 | W 5-0 | 23-19 | 2 | 34,120 | Cole Hamels | Chuck James | Cole Hamels | Chuck James | | 201 | 187 | 14 |
| 2008-05-16 | vs TOR | 43 | W 10-3 | 24-19 | 2 | 36,600 | Jamie Moyer | David Purcey | Jamie Moyer | David Purcey | | 211 | 190 | 21 |
| 2008-05-17 | vs TOR | 44 | L 3-6 | 24-20 | 2 | 42,604 | Adam Eaton | A.J. Burnett | A.J. Burnett | Adam Eaton | B.J. Ryan | 214 | 196 | 18 |
| 2008-05-18 | vs TOR | 45 | L 5-6 | 24-21 | 3 | 42,858 | Kyle Kendrick | Shaun Marcum | Jason Frasor | Rudy Seanez | B.J. Ryan | 219 | 202 | 17 |
| 2008-05-19 | @ WAS | 46 | L 0-4 | 24-22 | 3 | 25,394 | Brett Myers | Tim Redding | Tim Redding | Brett Myers | | 219 | 206 | 13 |
| 2008-05-20 | @ WAS | 47 | W 1-0 | 25-22 | 3 | 28,105 | Cole Hamels | Jason Bergmann | Tom Gordon | Jon Rauch | Brad Lidge | 220 | 206 | 14 |
| 2008-05-21 | @ WAS | 48 | W 12-2 | 26-22 | 3 | 28,055 | Jamie Moyer | Matt Chico | Jamie Moyer | Matt Chico | Clay Condrey | 232 | 208 | 24 |
| 2008-05-22 | @ HOU | 49 | W 7-5 | 27-22 | 3 | 29,263 | Kyle Kendrick | Roy Oswalt | Chad Durbin | Wesley Wright | Brad Lidge | 239 | 213 | 26 |
| 2008-05-23 | @ HOU | 50 | L 3-4 | 27-23 | 3 | 41,152 | Adam Eaton | Brandon Backe | Brandon Backe | Adam Eaton | Jose Valverde | 242 | 217 | 25 |
| 2008-05-24 | @ HOU | 51 | L 3-4 | 27-24 | 3 | 42,660 | Brett Myers | Brian Moehler | Brian Moehler | Brett Myers | Doug Brocail | 245 | 221 | 24 |
| 2008-05-25 | @ HOU | 52 | W 15-6 | 28-24 | 3 | 43,079 | Cole Hamels | Chris Sampson | Rudy Seanez | Fernando Nieve | | 260 | 227 | 33 |
| 2008-05-26 | vs COL | 53 | W 20-5 | 29-24 | 3 | 44,764 | Jamie Moyer | Jorge de la Rosa | Jamie Moyer | Jorge de la Rosa | | 280 | 232 | 48 |
| 2008-05-27 | vs COL | 54 | W 7-4 | 30-24 | 2 | 34,716 | Kyle Kendrick | Ubaldo Jimenez | Kyle Kendrick | Ubaldo Jimenez | | 287 | 236 | 51 |
| 2008-05-28 | vs COL | 55 | W 6-1 | 31-24 | 2 | 39,845 | Adam Eaton | Greg Reynolds | Adam Eaton | Greg Reynolds | | 293 | 237 | 56 |
| 2008-05-30 | vs FLO | 56 | W 12-3 | 32-24 | 1 | 45,118 | Brett Myers | Mark Hendrickson | Brett Myers | Mark Hendrickson | | 305 | 240 | 65 |
| 2008-05-31 | vs FLO | 57 | L 3-7 | 32-25 | 2 | 45,261 | Cole Hamels | Ricky Nolasco | Ricky Nolasco | Cole Hamels | | 308 | 247 | 61 |
| 2008-06-01 | vs FLO | 58 | W 7-5 | 33-25 | 1 | 45,312 | Jamie Moyer | Andrew Miller | Jamie Moyer | Doug Waechter | Brad Lidge | 315 | 252 | 63 |
| 2008-06-02 | vs CIN | 59 | W 5-4 | 34-25 | 1 | 38,530 | Kyle Kendrick | Bronson Arroyo | Kyle Kendrick | Bronson Arroyo | Brad Lidge | 320 | 256 | 64 |
| 2008-06-03 | vs CIN | 60 | W 3-2 | 35-25 | 1 | 45,096 | Adam Eaton | Aaron Harang | Adam Eaton | Aaron Harang | Brad Lidge | 323 | 258 | 65 |
| 2008-06-04 | vs CIN | 61 | L 0-2 | 35-26 | 1 | 45,223 | Brett Myers | Edinson Volquez | Edinson Volquez | Brett Myers | Francisco Cordero | 323 | 260 | 63 |
| 2008-06-05 | vs CIN | 62 | W 5-0 | 36-26 | 1 | 45,492 | Cole Hamels | Homer Bailey | Cole Hamels | Homer Bailey | | 328 | 260 | 68 |
| 2008-06-06 | @ ATL | 63 | W 4-3 | 37-26 | 1 | 34,074 | Jamie Moyer | Tim Hudson | Tom Gordon | Manny Acosta | Brad Lidge | 332 | 263 | 69 |
| 2008-06-07 | @ ATL | 64 | W 6-2 | 38-26 | 1 | 43,854 | Kyle Kendrick | Jo-Jo Reyes | J.C. Romero | Jo-Jo Reyes | | 338 | 265 | 73 |
| 2008-06-08 | @ ATL | 65 | W 6-3 | 39-26 | 1 | 33,370 | Adam Eaton | Jorge Campillo | Chad Durbin | Blaine Boyer | Brad Lidge | 344 | 268 | 76 |
| 2008-06-10 | @ FLO | 66 | L 4-5 | 39-27 | 1 | 12,411 | Brett Myers | Ricky Nolasco | Ricky Nolasco | Brett Myers | Kevin Gregg | 348 | 273 | 75 |
| 2008-06-11 | @ FLO | 67 | L 2-6 | 39-28 | 1 | 14,122 | Cole Hamels | Andrew Miller | Kevin Gregg | Tom Gordon | | 350 | 279 | 71 |
| 2008-06-12 | @ FLO | 68 | W 3-0 | 40-28 | 1 | 15,202 | Jamie Moyer | Scott Olsen | Jamie Moyer | Scott Olsen | Brad Lidge | 353 | 279 | 74 |
| 2008-06-13 | @ SLN | 69 | W 20-2 | 41-28 | 1 | 44,376 | Kyle Kendrick | Todd Wellemeyer | Kyle Kendrick | Todd Wellemeyer | | 373 | 281 | 92 |
| 2008-06-14 | @ SLN | 70 | L 2-3 | 41-29 | 1 | 45,089 | Adam Eaton | Kyle Lohse | Kyle Lohse | Adam Eaton | Ryan Franklin | 375 | 284 | 91 |
| 2008-06-15 | @ SLN | 71 | L 6-7 | 41-30 | 1 | 45,391 | Brett Myers | Mitchell Boggs | Anthony Reyes | Tom Gordon | | 381 | 291 | 90 |
| 2008-06-16 | vs BOS | 72 | W 8-2 | 42-30 | 1 | 45,026 | Cole Hamels | Bartolo Colon | Cole Hamels | Bartolo Colon | | 389 | 293 | 96 |
| 2008-06-17 | vs BOS | 73 | L 0-3 | 42-31 | 1 | 45,160 | Jamie Moyer | Jon Lester | Jon Lester | Jamie Moyer | Jonathan Papelbon | 389 | 296 | 93 |
| 2008-06-18 | vs BOS | 74 | L 4-7 | 42-32 | 1 | 45,187 | Kyle Kendrick | Justin Masterson | Justin Masterson | Kyle Kendrick | Jonathan Papelbon | 393 | 303 | 90 |
| 2008-06-20 | vs ANA | 75 | L 1-7 | 42-33 | 1 | 45,033 | Adam Eaton | Ervin Santana | Ervin Santana | Adam Eaton | | 394 | 310 | 84 |
| 2008-06-21 | vs ANA | 76 | L 2-6 | 42-34 | 1 | 45,196 | Brett Myers | Joe Saunders | Joe Saunders | Brett Myers | Francisco Rodriguez | 396 | 316 | 80 |
| 2008-06-22 | vs ANA | 77 | L 2-3 | 42-35 | 1 | 44,571 | Cole Hamels | Jered Weaver | Jered Weaver | Cole Hamels | Francisco Rodriguez | 398 | 319 | 79 |
| 2008-06-24 | @ OAK | 78 | L 2-5 | 42-36 | 1 | 13,348 | Jamie Moyer | Joe Blanton | Joe Blanton | Jamie Moyer | Huston Street | 400 | 324 | 76 |
| 2008-06-25 | @ OAK | 79 | W 4-0 | 43-36 | 1 | 22,231 | Kyle Kendrick | Greg Smith | Kyle Kendrick | Greg Smith | | 404 | 324 | 80 |
| 2008-06-26 | @ OAK | 80 | L 0-5 | 43-37 | 1 | 17,228 | Adam Eaton | Rich Harden | Rich Harden | Adam Eaton | | 404 | 329 | 75 |
| 2008-06-27 | @ TEX | 81 | L 7-8 | 43-38 | 1 | 28,623 | Brett Myers | Kason Gabbard | Josh Rupe | Clay Condrey | C.J. Wilson | 411 | 337 | 74 |
| 2008-06-28 | @ TEX | 82 | W 8-6 | 44-38 | 1 | 35,039 | Cole Hamels | Vicente Padilla | Cole Hamels | Vicente Padilla | Brad Lidge | 419 | 343 | 76 |
| 2008-06-29 | @ TEX | 83 | L 1-5 | 44-39 | 1 | 26,283 | Jamie Moyer | Eric Hurley | Eric Hurley | Jamie Moyer | | 420 | 348 | 72 |
| 2008-07-01 | @ ATL | 84 | W 8-3 | 45-39 | 1 | 29,206 | Kyle Kendrick | Charlie Morton | Kyle Kendrick | Charlie Morton | | 428 | 351 | 77 |
| 2008-07-02 | @ ATL | 85 | W 7-3 | 46-39 | 1 | 30,138 | Adam Eaton | Jorge Campillo | Adam Eaton | Jorge Campillo | | 435 | 354 | 81 |
| 2008-07-03 | @ ATL | 86 | W 4-1 | 47-39 | 1 | 28,805 | Cole Hamels | Jair Jurrjens | Cole Hamels | Jair Jurrjens | Tom Gordon | 439 | 355 | 84 |
| 2008-07-04 | vs NYN | 87 | W 3-2 | 48-39 | 1 | 44,922 | J.A. Happ | Johan Santana | Brad Lidge | Duaner Sanchez | | 442 | 357 | 85 |
| 2008-07-05 | vs NYN | 88 | L 4-9 | 48-40 | 1 | 45,190 | Jamie Moyer | John Maine | Pedro Feliciano | J.C. Romero | | 446 | 366 | 80 |
| 2008-07-06 | vs NYN | 89 | L 2-4 | 48-41 | 1 | 45,203 | Kyle Kendrick | Oliver Perez | Joe Smith | Chad Durbin | | 448 | 370 | 78 |
| 2008-07-07 | vs NYN | 90 | L 9-10 | 48-42 | 1 | 44,655 | Adam Eaton | Pedro Martinez | Pedro Martinez | Adam Eaton | Billy Wagner | 457 | 380 | 77 |
| 2008-07-08 | vs SLN | 91 | L 0-2 | 48-43 | 1 | 41,519 | Cole Hamels | Joel Pineiro | Joel Pineiro | Cole Hamels | Ryan Franklin | 457 | 382 | 75 |
| 2008-07-09 | vs SLN | 92 | W 4-2 | 49-43 | 1 | 44,951 | J.A. Happ | Mark Mulder | Clay Condrey | Kyle McClellan | Brad Lidge | 461 | 384 | 77 |
| 2008-07-10 | vs SLN | 93 | W 4-1 | 50-43 | 1 | 44,241 | Jamie Moyer | Braden Looper | Jamie Moyer | Braden Looper | J.C. Romero | 465 | 385 | 80 |
| 2008-07-11 | vs ARI | 94 | W 6-5 | 51-43 | 1 | 45,028 | Kyle Kendrick | Doug Davis | Rudy Seanez | Connor Robertson | | 471 | 390 | 81 |
| 2008-07-12 | vs ARI | 95 | L 4-10 | 51-44 | 1 | 45,006 | Adam Eaton | Randy Johnson | Randy Johnson | Adam Eaton | | 475 | 400 | 75 |
| 2008-07-13 | vs ARI | 96 | W 6-3 | 52-44 | 1 | 45,277 | Cole Hamels | Brandon Webb | Ryan Madson | Chad Qualls | | 481 | 403 | 78 |
| 2008-07-18 | @ FLO | 97 | W 4-2 | 53-44 | 1 | 23,124 | Jamie Moyer | Ricky Nolasco | Jamie Moyer | Ricky Nolasco | Brad Lidge | 485 | 405 | 80 |
| 2008-07-19 | @ FLO | 98 | L 5-9 | 53-45 | 1 | 26,520 | Kyle Kendrick | Scott Olsen | Scott Olsen | Kyle Kendrick | | 490 | 414 | 76 |
| 2008-07-20 | @ FLO | 99 | L 2-3 | 53-46 | 2 | 17,724 | Cole Hamels | Josh Johnson | Doug Waechter | Clay Condrey | | 492 | 417 | 75 |
| 2008-07-22 | @ NYN | 100 | W 8-6 | 54-46 | 1 | 55,081 | Joe Blanton | Johan Santana | Chad Durbin | Joe Smith | Brad Lidge | 500 | 423 | 77 |
| 2008-07-23 | @ NYN | 101 | L 3-6 | 54-47 | 2 | 53,444 | Brett Myers | John Maine | John Maine | Ryan Madson | Billy Wagner | 503 | 429 | 74 |
| 2008-07-24 | @ NYN | 102 | L 1-3 | 54-48 | 2 | 50,962 | Jamie Moyer | Oliver Perez | Aaron Heilman | J.C. Romero | Billy Wagner | 504 | 432 | 72 |
| 2008-07-25 | vs ATL | 103 | L 2-8 | 54-49 | 3 | 45,114 | Kyle Kendrick | Jair Jurrjens | Jair Jurrjens | Kyle Kendrick | | 506 | 440 | 66 |
| 2008-07-26 | vs ATL | 104 | W 10-9 | 55-49 | 3 | 45,107 | Cole Hamels | Mike Hampton | Adam Eaton | Blaine Boyer | Brad Lidge | 516 | 449 | 67 |
| 2008-07-27 | vs ATL | 105 | W 12-10 | 56-49 | 2 | 45,096 | Joe Blanton | Jorge Campillo | Clay Condrey | Julian Tavarez | Brad Lidge | 528 | 459 | 69 |
| 2008-07-29 | @ WAS | 106 | W 2-1 | 57-49 | 2 | 34,039 | Brett Myers | Collin Balester | Brett Myers | Collin Balester | Brad Lidge | 530 | 460 | 70 |
| 2008-07-30 | @ WAS | 107 | W 8-5 | 58-49 | 1 | 31,798 | Jamie Moyer | Tim Redding | Jamie Moyer | Tim Redding | Brad Lidge | 538 | 465 | 73 |
| 2008-07-31 | @ WAS | 108 | W 8-4 | 59-49 | 1 | 31,658 | Kyle Kendrick | John Lannan | Kyle Kendrick | John Lannan | | 546 | 469 | 77 |
| 2008-08-01 | @ SLN | 109 | L 3-6 | 59-50 | 1 | 44,234 | Cole Hamels | Kyle Lohse | Kyle Lohse | Cole Hamels | Jason Isringhausen | 549 | 475 | 74 |
| 2008-08-02 | @ SLN | 110 | W 2-1 | 60-50 | 1 | 45,450 | Joe Blanton | Braden Looper | Joe Blanton | Braden Looper | Brad Lidge | 551 | 476 | 75 |
| 2008-08-03 | @ SLN | 111 | W 5-4 | 61-50 | 1 | 44,655 | Brett Myers | Todd Wellemeyer | Chad Durbin | Jaime Garcia | Brad Lidge | 556 | 480 | 76 |
| 2008-08-05 | vs FLO | 112 | L 2-8 | 61-51 | 1 | 44,896 | Jamie Moyer | Josh Johnson | Josh Johnson | Jamie Moyer | | 558 | 488 | 70 |
| 2008-08-06 | vs FLO | 113 | W 5-0 | 62-51 | 1 | 45,078 | Kyle Kendrick | Anibal Sanchez | Kyle Kendrick | Anibal Sanchez | | 563 | 488 | 75 |
| 2008-08-07 | vs FLO | 114 | L 0-3 | 62-52 | 1 | 45,521 | Cole Hamels | Chris Volstad | Chris Volstad | Cole Hamels | Kevin Gregg | 563 | 491 | 72 |
| 2008-08-08 | vs PIT | 115 | L 0-2 | 62-53 | 1 | 43,891 | Joe Blanton | Paul Maholm | T.J. Beam | Les Walrond | Craig Hansen | 563 | 493 | 70 |
| 2008-08-09 | vs PIT | 116 | W 4-2 | 63-53 | 1 | 45,060 | Brett Myers | Ian Snell | Brett Myers | Ian Snell | Chad Durbin | 567 | 495 | 72 |
| 2008-08-10 | vs PIT | 117 | W 6-3 | 64-53 | 1 | 45,262 | Jamie Moyer | Jason Davis | Scott Eyre | Tyler Yates | Ryan Madson | 573 | 498 | 75 |
| 2008-08-11 | @ LAN | 118 | L 6-8 | 64-54 | 1 | 45,547 | Kyle Kendrick | Derek Lowe | Derek Lowe | Kyle Kendrick | Jonathan Broxton | 579 | 506 | 73 |
| 2008-08-12 | @ LAN | 119 | L 3-4 | 64-55 | 1 | 47,586 | Cole Hamels | Clayton Kershaw | Hong-Chih Kuo | J.C. Romero | | 582 | 510 | 72 |
| 2008-08-13 | @ LAN | 120 | L 6-7 | 64-56 | 2 | 45,786 | Joe Blanton | Brad Penny | Jonathan Broxton | Clay Condrey | | 588 | 517 | 71 |
| 2008-08-14 | @ LAN | 121 | L 1-3 | 64-57 | 2 | 51,060 | Brett Myers | Hiroki Kuroda | Hiroki Kuroda | Brett Myers | Hong-Chih Kuo | 589 | 520 | 69 |
| 2008-08-15 | @ SDN | 122 | W 1-0 | 65-57 | 2 | 37,558 | Jamie Moyer | Greg Maddux | Jamie Moyer | Greg Maddux | Brad Lidge | 590 | 520 | 70 |
| 2008-08-16 | @ SDN | 123 | L 3-8 | 65-58 | 2 | 33,956 | Kyle Kendrick | Chad Reineke | Chad Reineke | Kyle Kendrick | | 593 | 528 | 65 |
| 2008-08-17 | @ SDN | 124 | W 2-1 | 66-58 | 2 | 34,756 | Cole Hamels | Cha-Seung Baek | Cole Hamels | Cha-Seung Baek | Brad Lidge | 595 | 529 | 66 |
| 2008-08-19 | vs WAS | 125 | W 5-4 | 67-58 | 2 | 44,143 | Joe Blanton | Jason Bergmann | Ryan Madson | Steven Shell | Brad Lidge | 600 | 533 | 67 |
| 2008-08-20 | vs WAS | 126 | W 4-0 | 68-58 | 2 | 45,166 | Brett Myers | Collin Balester | Brett Myers | Collin Balester | | 604 | 533 | 71 |
| 2008-08-21 | vs WAS | 127 | L 3-4 | 68-59 | 2 | 41,568 | Jamie Moyer | Tim Redding | Saul Rivera | Ryan Madson | Joel Hanrahan | 607 | 537 | 70 |
| 2008-08-22 | vs LAN | 128 | W 8-1 | 69-59 | 2 | 42,620 | Kyle Kendrick | Greg Maddux | Kyle Kendrick | Greg Maddux | | 615 | 538 | 77 |
| 2008-08-23 | vs LAN | 129 | W 9-2 | 70-59 | 2 | 45,019 | Cole Hamels | Clayton Kershaw | Cole Hamels | Clayton Kershaw | | 624 | 540 | 84 |
| 2008-08-24 | vs LAN | 130 | W 5-2 | 71-59 | 2 | 43,039 | Joe Blanton | Hiroki Kuroda | Chad Durbin | Joe Beimel | | 629 | 542 | 87 |
| 2008-08-25 | vs LAN | 131 | W 5-0 | 72-59 | 2 | 40,873 | Brett Myers | Chad Billingsley | Brett Myers | Chad Billingsley | | 634 | 542 | 92 |
| 2008-08-26 | vs NYN | 132 | W 8-7 | 73-59 | 1 | 45,204 | Jamie Moyer | Pedro Martinez | Rudy Seanez | Scott Schoeneweis | | 642 | 549 | 93 |
| 2008-08-27 | vs NYN | 133 | L 3-6 | 73-60 | 2 | 45,138 | Kyle Kendrick | Johan Santana | Brian Stokes | Rudy Seanez | Luis Ayala | 645 | 555 | 90 |
| 2008-08-28 | @ CHN | 134 | L 4-6 | 73-61 | 2 | 40,362 | Cole Hamels | Ryan Dempster | Bob Howry | Chad Durbin | Kerry Wood | 649 | 561 | 88 |
| 2008-08-29 | @ CHN | 135 | L 2-3 | 73-62 | 2 | 40,844 | Joe Blanton | Rich Harden | Jeff Samardzija | Clay Condrey | Carlos Marmol | 651 | 564 | 87 |
| 2008-08-30 | @ CHN | 136 | W 5-2 | 74-62 | 2 | 41,511 | Brett Myers | Ted Lilly | Brett Myers | Ted Lilly | Brad Lidge | 656 | 566 | 90 |
| 2008-08-31 | @ CHN | 137 | W 5-3 | 75-62 | 2 | 41,544 | Jamie Moyer | Sean Marshall | Jamie Moyer | Sean Marshall | Brad Lidge | 661 | 569 | 92 |
| 2008-09-01 | @ WAS | 138 | L 4-7 | 75-63 | 2 | 28,393 | Kyle Kendrick | Tim Redding | Tim Redding | Kyle Kendrick | | 665 | 576 | 89 |
| 2008-09-02 | @ WAS | 139 | W 4-0 | 76-63 | 2 | 23,150 | Cole Hamels | John Lannan | Cole Hamels | John Lannan | | 669 | 576 | 93 |
| 2008-09-03 | @ WAS | 140 | L 7-9 | 76-64 | 2 | 23,122 | Joe Blanton | Odalis Perez | Saul Rivera | Chad Durbin | | 676 | 585 | 91 |
| 2008-09-05 | @ NYN | 141 | W 3-0 | 77-64 | 2 | 48,302 | Brett Myers | Mike Pelfrey | Brett Myers | Mike Pelfrey | Brad Lidge | 679 | 585 | 94 |
| 2008-09-07 | @ NYN | 142 | W 6-2 | 78-65 | 2 | 55,797 | Jamie Moyer | Pedro Martinez | Jamie Moyer | Pedro Martinez | | 685 | 587 | 98 |
| 2008-09-07 | @ NYN | 143 | L 3-6 | 78-65 | 2 | 54,980 | Cole Hamels | Johan Santana | Johan Santana | Cole Hamels | | 688 | 593 | 95 |
| 2008-09-08 | vs FLO | 144 | W 8-6 | 79-65 | 2 | 38,921 | Joe Blanton | Anibal Sanchez | Joe Blanton | Anibal Sanchez | Brad Lidge | 696 | 599 | 97 |
| 2008-09-09 | vs FLO | 145 | L 8-10 | 79-66 | 2 | 40,554 | Kyle Kendrick | Chris Volstad | Kevin Gregg | Kyle Kendrick | Matt Lindstrom | 704 | 609 | 95 |
| 2008-09-10 | vs FLO | 146 | L 3-7 | 79-67 | 2 | 38,665 | Brett Myers | Ricky Nolasco | Ricky Nolasco | Brett Myers | | 707 | 616 | 91 |
| 2008-09-11 | vs MIL | 147 | W 6-3 | 80-67 | 2 | 39,994 | Jamie Moyer | Ben Sheets | Jamie Moyer | Ben Sheets | Brad Lidge | 713 | 619 | 94 |
| 2008-09-13 | vs MIL | 148 | W 7-3 | 81-67 | 2 | 45,105 | Cole Hamels | Manny Parra | Cole Hamels | Manny Parra | | 720 | 622 | 98 |
| 2008-09-14 | vs MIL | 149 | W 7-3 | 83-67 | 2 | 43,950 | Joe Blanton | David Bush | Scott Eyre | Guillermo Mota | | 727 | 625 | 102 |
| 2008-09-14 | vs MIL | 150 | W 6-1 | 83-67 | 2 | 39,776 | Brett Myers | Jeff Suppan | Brett Myers | Jeff Suppan | | 733 | 626 | 107 |
| 2008-09-16 | @ ATL | 151 | W 8-7 | 84-67 | 1 | 30,319 | Jamie Moyer | James Parr | Ryan Madson | Mike Gonzalez | Brad Lidge | 741 | 633 | 108 |
| 2008-09-17 | @ ATL | 152 | W 6-1 | 85-67 | 1 | 32,821 | J.A. Happ | Jair Jurrjens | J.A. Happ | Jair Jurrjens | | 747 | 634 | 113 |
| 2008-09-18 | @ ATL | 153 | W 4-3 | 86-67 | 1 | 39,070 | Cole Hamels | Mike Hampton | Cole Hamels | Mike Hampton | Brad Lidge | 751 | 637 | 114 |
| 2008-09-19 | @ FLO | 154 | L 8-14 | 86-68 | 2 | 20,202 | Brett Myers | Josh Johnson | Josh Johnson | Brett Myers | | 759 | 651 | 108 |
| 2008-09-20 | @ FLO | 155 | W 3-2 | 87-68 | 1 | 28,757 | Joe Blanton | Anibal Sanchez | Joe Blanton | Anibal Sanchez | Brad Lidge | 762 | 653 | 109 |
| 2008-09-21 | @ FLO | 156 | W 5-2 | 88-68 | 1 | 28,173 | Jamie Moyer | Chris Volstad | Jamie Moyer | Chris Volstad | Brad Lidge | 767 | 655 | 112 |
| 2008-09-22 | vs ATL | 157 | W 6-2 | 89-68 | 1 | 36,796 | J.A. Happ | Jair Jurrjens | Scott Eyre | Jeff Bennett | | 773 | 657 | 116 |
| 2008-09-23 | vs ATL | 158 | L 2-3 | 89-69 | 1 | 39,322 | Cole Hamels | Mike Hampton | Mike Hampton | Cole Hamels | Mike Gonzalez | 775 | 660 | 115 |
| 2008-09-24 | vs ATL | 159 | L 4-10 | 89-70 | 1 | 41,430 | Brett Myers | Jo-Jo Reyes | Buddy Carlyle | Brett Myers | | 779 | 670 | 109 |
| 2008-09-26 | vs WAS | 160 | W 8-4 | 90-70 | 1 | 44,145 | Joe Blanton | Collin Balester | Joe Blanton | Collin Balester | | 787 | 674 | 113 |
| 2008-09-27 | vs WAS | 161 | W 4-3 | 91-70 | 1 | 45,177 | Jamie Moyer | John Lannan | Jamie Moyer | John Lannan | Brad Lidge | 791 | 677 | 114 |
| 2008-09-28 | vs WAS | 162 | W 8-3 | 92-70 | 1 | 44,945 | Kyle Kendrick | Odalis Perez | Les Walrond | Odalis Perez | | 799 | 680 | 119 |