| 2008-03-31 | vs ANA | 1 | W 3-2 | 1-0 | 3 | 49,596 | Livan Hernandez | Jered Weaver | Livan Hernandez | Jered Weaver | Joe Nathan | 3 | 2 | 1 |
| 2008-04-01 | vs ANA | 2 | L 1-9 | 1-1 | 3 | 24,586 | Boof Bonser | Jon Garland | Jon Garland | Boof Bonser | | 4 | 11 | -7 |
| 2008-04-02 | vs ANA | 3 | L 0-1 | 1-2 | 3 | 21,932 | Nick Blackburn | Joe Saunders | Joe Saunders | Nick Blackburn | Francisco Rodriguez | 4 | 12 | -8 |
| 2008-04-03 | vs ANA | 4 | L 4-5 | 1-3 | 4 | 17,084 | Kevin Slowey | Ervin Santana | Ervin Santana | Kevin Slowey | Francisco Rodriguez | 8 | 17 | -9 |
| 2008-04-04 | vs KCA | 5 | W 4-3 | 2-3 | 4 | 21,847 | Scott Baker | John Bale | Scott Baker | John Bale | Joe Nathan | 12 | 20 | -8 |
| 2008-04-05 | vs KCA | 6 | W 6-4 | 3-3 | 3 | 21,262 | Livan Hernandez | Gil Meche | Livan Hernandez | Gil Meche | Joe Nathan | 18 | 24 | -6 |
| 2008-04-06 | vs KCA | 7 | L 1-3 | 3-4 | 4 | 21,765 | Boof Bonser | Brett Tomko | Brett Tomko | Boof Bonser | Joakim Soria | 19 | 27 | -8 |
| 2008-04-07 | @ CHA | 8 | L 4-7 | 3-5 | 4 | 38,082 | Nick Blackburn | Javier Vazquez | Javier Vazquez | Matt Guerrier | Bobby Jenks | 23 | 34 | -11 |
| 2008-04-09 | @ CHA | 9 | W 12-5 | 4-5 | 4 | 16,499 | Scott Baker | John Danks | Scott Baker | John Danks | Brian Bass | 35 | 39 | -4 |
| 2008-04-11 | @ KCA | 10 | W 5-0 | 5-5 | 3 | 16,691 | Livan Hernandez | Gil Meche | Livan Hernandez | Gil Meche | | 40 | 39 | 1 |
| 2008-04-12 | @ KCA | 11 | W 2-0 | 6-5 | 3 | 36,300 | Boof Bonser | Brett Tomko | Boof Bonser | Brett Tomko | Joe Nathan | 42 | 39 | 3 |
| 2008-04-13 | @ KCA | 12 | L 1-5 | 6-6 | 3 | 13,886 | Francisco Liriano | Brian Bannister | Brian Bannister | Francisco Liriano | | 43 | 44 | -1 |
| 2008-04-14 | @ DET | 13 | L 9-11 | 6-7 | 3 | 32,002 | Nick Blackburn | Jeremy Bonderman | Francis Beltran | Pat Neshek | Todd Jones | 52 | 55 | -3 |
| 2008-04-15 | @ DET | 14 | L 5-6 | 6-8 | 3 | 30,901 | Scott Baker | Nate Robertson | Clay Rapada | Jesse Crain | Todd Jones | 57 | 61 | -4 |
| 2008-04-16 | vs TBA | 15 | W 6-5 | 7-8 | 3 | 20,209 | Livan Hernandez | James Shields | Juan Rincon | Dan Wheeler | Joe Nathan | 63 | 66 | -3 |
| 2008-04-17 | vs TBA | 16 | L 3-7 | 7-9 | 3 | 14,781 | Boof Bonser | Jason Hammel | Jason Hammel | Boof Bonser | J.P. Howell | 66 | 73 | -7 |
| 2008-04-18 | vs CLE | 17 | L 0-4 | 7-10 | 4 | 22,366 | Francisco Liriano | Cliff Lee | Cliff Lee | Francisco Liriano | | 66 | 77 | -11 |
| 2008-04-19 | vs CLE | 18 | W 3-0 | 8-10 | 3 | 34,210 | Nick Blackburn | Jake Westbrook | Nick Blackburn | Jake Westbrook | Joe Nathan | 69 | 77 | -8 |
| 2008-04-20 | vs CLE | 19 | W 2-1 | 9-10 | 3 | 27,703 | Scott Baker | Paul Byrd | Matt Guerrier | Rafael Perez | | 71 | 78 | -7 |
| 2008-04-22 | @ OAK | 20 | W 5-4 | 10-10 | 2 | 10,267 | Livan Hernandez | Joe Blanton | Juan Rincon | Joe Blanton | Joe Nathan | 76 | 82 | -6 |
| 2008-04-23 | @ OAK | 21 | L 0-3 | 10-11 | 2 | 15,242 | Boof Bonser | Chad Gaudin | Chad Gaudin | Boof Bonser | Huston Street | 76 | 85 | -9 |
| 2008-04-24 | @ OAK | 22 | L 2-11 | 10-12 | 3 | 12,593 | Francisco Liriano | Greg Smith | Greg Smith | Francisco Liriano | | 78 | 96 | -18 |
| 2008-04-25 | @ TEX | 23 | L 5-6 | 10-13 | 4 | 19,016 | Nick Blackburn | Kevin Millwood | Joaquin Benoit | Juan Rincon | | 83 | 102 | -19 |
| 2008-04-26 | @ TEX | 24 | W 12-6 | 11-13 | 4 | 33,053 | Scott Baker | Sidney Ponson | Dennys Reyes | Jamey Wright | | 95 | 108 | -13 |
| 2008-04-27 | @ TEX | 25 | L 0-10 | 11-14 | 4 | 19,911 | Livan Hernandez | Vicente Padilla | Vicente Padilla | Livan Hernandez | | 95 | 118 | -23 |
| 2008-04-29 | vs CHA | 26 | W 3-1 | 12-14 | 3 | 20,891 | Boof Bonser | Gavin Floyd | Boof Bonser | Gavin Floyd | Joe Nathan | 98 | 119 | -21 |
| 2008-04-30 | vs CHA | 27 | W 4-3 | 13-14 | 2 | 19,137 | Nick Blackburn | Nick Masset | Nick Blackburn | Ehren Wassermann | Joe Nathan | 102 | 122 | -20 |
| 2008-05-02 | vs DET | 28 | W 11-1 | 14-14 | 2 | 33,628 | Livan Hernandez | Armando Galarraga | Livan Hernandez | Armando Galarraga | | 113 | 123 | -10 |
| 2008-05-03 | vs DET | 29 | W 4-1 | 15-14 | 1 | 28,985 | Scott Baker | Justin Verlander | Brian Bass | Justin Verlander | Joe Nathan | 117 | 124 | -7 |
| 2008-05-04 | vs DET | 30 | W 7-6 | 16-14 | 1 | 29,821 | Boof Bonser | Kenny Rogers | Matt Guerrier | Zach Miner | Joe Nathan | 124 | 130 | -6 |
| 2008-05-06 | @ CHA | 31 | L 1-7 | 16-15 | 1 | 23,480 | Nick Blackburn | Gavin Floyd | Gavin Floyd | Nick Blackburn | | 125 | 137 | -12 |
| 2008-05-07 | @ CHA | 32 | W 13-1 | 17-15 | 1 | 21,092 | Livan Hernandez | Mark Buehrle | Livan Hernandez | Mark Buehrle | | 138 | 138 | 0 |
| 2008-05-08 | @ CHA | 33 | L 2-6 | 17-16 | 1 | 25,193 | Kevin Slowey | John Danks | John Danks | Kevin Slowey | | 140 | 144 | -4 |
| 2008-05-09 | vs BOS | 34 | W 7-6 | 18-16 | 1 | 25,477 | Boof Bonser | Jon Lester | Jesse Crain | Jonathan Papelbon | | 147 | 150 | -3 |
| 2008-05-10 | vs BOS | 35 | L 2-5 | 18-17 | 1 | 33,839 | Glen Perkins | Daisuke Matsuzaka | Daisuke Matsuzaka | Glen Perkins | Jonathan Papelbon | 149 | 155 | -6 |
| 2008-05-11 | vs BOS | 36 | W 9-8 | 19-17 | 1 | 26,511 | Nick Blackburn | Tim Wakefield | Nick Blackburn | Tim Wakefield | Joe Nathan | 158 | 163 | -5 |
| 2008-05-12 | vs BOS | 37 | W 7-3 | 20-17 | 1 | 18,782 | Livan Hernandez | Clay Buchholz | Livan Hernandez | Clay Buchholz | | 165 | 166 | -1 |
| 2008-05-13 | vs TOR | 38 | L 3-5 | 20-18 | 1 | 18,110 | Kevin Slowey | Jesse Litsch | Jesse Litsch | Kevin Slowey | B.J. Ryan | 168 | 171 | -3 |
| 2008-05-14 | vs TOR | 39 | L 5-6 | 20-19 | 2 | 21,026 | Boof Bonser | Roy Halladay | Roy Halladay | Boof Bonser | Scott Downs | 173 | 177 | -4 |
| 2008-05-15 | vs TOR | 40 | L 2-3 | 20-20 | 2 | 18,701 | Glen Perkins | Dustin McGowan | Shawn Camp | Jesse Crain | B.J. Ryan | 175 | 180 | -5 |
| 2008-05-16 | @ COL | 41 | W 4-2 | 21-20 | 2 | 35,336 | Nick Blackburn | Ubaldo Jimenez | Nick Blackburn | Ubaldo Jimenez | Joe Nathan | 179 | 182 | -3 |
| 2008-05-17 | @ COL | 42 | L 2-3 | 21-21 | 3 | 43,149 | Livan Hernandez | Greg Reynolds | Matt Herges | Livan Hernandez | Brian Fuentes | 181 | 185 | -4 |
| 2008-05-18 | @ COL | 43 | L 2-6 | 21-22 | 4 | 40,326 | Kevin Slowey | Jeff Francis | Jeff Francis | Kevin Slowey | | 183 | 191 | -8 |
| 2008-05-19 | vs TEX | 44 | W 7-6 | 22-22 | 3 | 16,680 | Boof Bonser | Scott Feldman | Bobby Korecky | Franklyn German | | 190 | 197 | -7 |
| 2008-05-20 | vs TEX | 45 | W 11-4 | 23-22 | 2 | 19,376 | Glen Perkins | Doug Mathis | Glen Perkins | Doug Mathis | | 201 | 201 | 0 |
| 2008-05-21 | vs TEX | 46 | L 1-10 | 23-23 | 2 | 22,032 | Nick Blackburn | Sidney Ponson | Sidney Ponson | Nick Blackburn | | 202 | 211 | -9 |
| 2008-05-22 | vs TEX | 47 | L 7-8 | 23-24 | 2 | 23,126 | Livan Hernandez | Vicente Padilla | Joaquin Benoit | Brian Bass | C.J. Wilson | 209 | 219 | -10 |
| 2008-05-23 | @ DET | 48 | W 9-4 | 24-24 | 2 | 40,732 | Kevin Slowey | Armando Galarraga | Kevin Slowey | Armando Galarraga | | 218 | 223 | -5 |
| 2008-05-24 | @ DET | 49 | L 3-19 | 24-25 | 2 | 41,137 | Boof Bonser | Nate Robertson | Nate Robertson | Boof Bonser | | 221 | 242 | -21 |
| 2008-05-25 | @ DET | 50 | W 6-1 | 25-25 | 2 | 42,413 | Glen Perkins | Justin Verlander | Glen Perkins | Francisco Cruceta | | 227 | 243 | -16 |
| 2008-05-27 | @ KCA | 51 | W 4-3 | 26-25 | 2 | 17,191 | Nick Blackburn | Brian Bannister | Jesse Crain | Leo Nunez | Matt Guerrier | 231 | 246 | -15 |
| 2008-05-28 | @ KCA | 52 | W 9-8 | 27-25 | 2 | 13,621 | Livan Hernandez | Zack Greinke | Jesse Crain | Joel Peralta | Joe Nathan | 240 | 254 | -14 |
| 2008-05-29 | @ KCA | 53 | W 5-1 | 28-25 | 2 | 12,336 | Kevin Slowey | Luke Hochevar | Kevin Slowey | Luke Hochevar | | 245 | 255 | -10 |
| 2008-05-30 | vs NYA | 54 | L 5-6 | 28-26 | 2 | 30,188 | Glen Perkins | Mike Mussina | Mike Mussina | Glen Perkins | Mariano Rivera | 250 | 261 | -11 |
| 2008-05-31 | vs NYA | 55 | L 6-7 | 28-27 | 2 | 36,441 | Boof Bonser | Chien-Ming Wang | Ross Ohlendorf | Juan Rincon | Mariano Rivera | 256 | 268 | -12 |
| 2008-06-01 | vs NYA | 56 | W 5-1 | 29-27 | 2 | 27,479 | Nick Blackburn | Darrell Rasner | Brian Bass | Darrell Rasner | | 261 | 269 | -8 |
| 2008-06-02 | vs NYA | 57 | W 6-5 | 30-27 | 2 | 20,168 | Livan Hernandez | Andy Pettitte | Matt Guerrier | Kyle Farnsworth | Joe Nathan | 267 | 274 | -7 |
| 2008-06-03 | vs BAL | 58 | L 3-5 | 30-28 | 2 | 18,802 | Kevin Slowey | Radhames Liz | Radhames Liz | Kevin Slowey | George Sherrill | 270 | 279 | -9 |
| 2008-06-04 | vs BAL | 59 | W 7-5 | 31-28 | 2 | 22,057 | Glen Perkins | Daniel Cabrera | Boof Bonser | Daniel Cabrera | Joe Nathan | 277 | 284 | -7 |
| 2008-06-05 | vs BAL | 60 | L 2-3 | 31-29 | 2 | 19,621 | Scott Baker | Garrett Olson | Garrett Olson | Brian Bass | George Sherrill | 279 | 287 | -8 |
| 2008-06-06 | @ CHA | 61 | L 6-10 | 31-30 | 2 | 26,459 | Nick Blackburn | Javier Vazquez | Javier Vazquez | Nick Blackburn | | 285 | 297 | -12 |
| 2008-06-07 | @ CHA | 62 | L 2-11 | 31-31 | 2 | 32,930 | Livan Hernandez | Mark Buehrle | Mark Buehrle | Livan Hernandez | | 287 | 308 | -21 |
| 2008-06-08 | @ CHA | 63 | L 2-12 | 31-32 | 2 | 30,565 | Kevin Slowey | Gavin Floyd | Gavin Floyd | Kevin Slowey | | 289 | 320 | -31 |
| 2008-06-09 | @ CHA | 64 | L 5-7 | 31-33 | 2 | 21,126 | Glen Perkins | John Danks | Matt Thornton | Matt Guerrier | Bobby Jenks | 294 | 327 | -33 |
| 2008-06-10 | @ CLE | 65 | L 0-1 | 31-34 | 2 | 26,874 | Scott Baker | CC Sabathia | CC Sabathia | Scott Baker | | 294 | 328 | -34 |
| 2008-06-11 | @ CLE | 66 | W 8-5 | 32-34 | 2 | 18,742 | Nick Blackburn | Paul Byrd | Nick Blackburn | Paul Byrd | Joe Nathan | 302 | 333 | -31 |
| 2008-06-12 | @ CLE | 67 | L 2-12 | 32-35 | 2 | 21,716 | Livan Hernandez | Aaron Laffey | Aaron Laffey | Livan Hernandez | | 304 | 345 | -41 |
| 2008-06-13 | @ MIL | 68 | W 10-2 | 33-35 | 2 | 38,586 | Kevin Slowey | David Bush | Kevin Slowey | David Bush | | 314 | 347 | -33 |
| 2008-06-14 | @ MIL | 69 | W 9-4 | 34-35 | 2 | 43,812 | Glen Perkins | Jeff Suppan | Brian Bass | Julian Tavarez | | 323 | 351 | -28 |
| 2008-06-15 | @ MIL | 70 | L 2-4 | 34-36 | 2 | 41,693 | Scott Baker | Seth McClung | Seth McClung | Scott Baker | Salomon Torres | 325 | 355 | -30 |
| 2008-06-17 | vs WAS | 71 | W 2-1 | 35-36 | 2 | 20,920 | Livan Hernandez | John Lannan | Livan Hernandez | John Lannan | Joe Nathan | 327 | 356 | -29 |
| 2008-06-18 | vs WAS | 72 | W 11-2 | 36-36 | 2 | 23,841 | Kevin Slowey | Jason Bergmann | Kevin Slowey | Jason Bergmann | | 338 | 358 | -20 |
| 2008-06-19 | vs WAS | 73 | W 9-3 | 37-36 | 2 | 24,793 | Glen Perkins | Shawn Hill | Glen Perkins | Shawn Hill | | 347 | 361 | -14 |
| 2008-06-20 | vs ARI | 74 | W 7-2 | 38-36 | 2 | 29,069 | Scott Baker | Randy Johnson | Scott Baker | Randy Johnson | | 354 | 363 | -9 |
| 2008-06-21 | vs ARI | 75 | W 6-1 | 39-36 | 2 | 25,505 | Nick Blackburn | Micah Owings | Nick Blackburn | Micah Owings | | 360 | 364 | -4 |
| 2008-06-22 | vs ARI | 76 | W 5-3 | 40-36 | 2 | 31,497 | Livan Hernandez | Brandon Webb | Livan Hernandez | Brandon Webb | Joe Nathan | 365 | 367 | -2 |
| 2008-06-24 | @ SDN | 77 | W 3-1 | 41-36 | 2 | 36,948 | Kevin Slowey | Jake Peavy | Dennys Reyes | Trevor Hoffman | Joe Nathan | 368 | 368 | 0 |
| 2008-06-25 | @ SDN | 78 | W 9-3 | 42-36 | 2 | 22,324 | Glen Perkins | Greg Maddux | Glen Perkins | Greg Maddux | | 377 | 371 | 6 |
| 2008-06-26 | @ SDN | 79 | W 4-3 | 43-36 | 2 | 28,789 | Scott Baker | Josh Banks | Scott Baker | Josh Banks | Joe Nathan | 381 | 374 | 7 |
| 2008-06-27 | vs MIL | 80 | W 7-6 | 44-36 | 2 | 30,104 | Nick Blackburn | Seth McClung | Matt Guerrier | Guillermo Mota | Joe Nathan | 388 | 380 | 8 |
| 2008-06-28 | vs MIL | 81 | L 1-5 | 44-37 | 2 | 38,963 | Livan Hernandez | Manny Parra | Manny Parra | Livan Hernandez | | 389 | 385 | 4 |
| 2008-06-29 | vs MIL | 82 | W 5-0 | 45-37 | 2 | 30,655 | Kevin Slowey | Ben Sheets | Kevin Slowey | Ben Sheets | | 394 | 385 | 9 |
| 2008-06-30 | vs DET | 83 | L 4-5 | 45-38 | 2 | 22,196 | Glen Perkins | Armando Galarraga | Casey Fossum | Matt Guerrier | Joel Zumaya | 398 | 390 | 8 |
| 2008-07-01 | vs DET | 84 | W 6-4 | 46-38 | 2 | 23,754 | Scott Baker | Nate Robertson | Scott Baker | Nate Robertson | Joe Nathan | 404 | 394 | 10 |
| 2008-07-02 | vs DET | 85 | W 7-0 | 47-38 | 2 | 30,102 | Nick Blackburn | Eddie Bonine | Nick Blackburn | Eddie Bonine | | 411 | 394 | 17 |
| 2008-07-04 | vs CLE | 86 | W 12-3 | 48-38 | 2 | 22,634 | Livan Hernandez | Paul Byrd | Livan Hernandez | Paul Byrd | | 423 | 397 | 26 |
| 2008-07-05 | vs CLE | 87 | W 9-6 | 49-38 | 2 | 31,887 | Kevin Slowey | Aaron Laffey | Kevin Slowey | Tom Mastny | Joe Nathan | 432 | 403 | 29 |
| 2008-07-06 | vs CLE | 88 | W 4-3 | 50-38 | 2 | 30,258 | Glen Perkins | Cliff Lee | Glen Perkins | Cliff Lee | Joe Nathan | 436 | 406 | 30 |
| 2008-07-07 | @ BOS | 89 | L 0-1 | 50-39 | 2 | 37,912 | Scott Baker | Daisuke Matsuzaka | Hideki Okajima | Brian Bass | Jonathan Papelbon | 436 | 407 | 29 |
| 2008-07-08 | @ BOS | 90 | L 5-6 | 50-40 | 2 | 37,925 | Nick Blackburn | Jon Lester | David Aardsma | Matt Guerrier | Jonathan Papelbon | 441 | 413 | 28 |
| 2008-07-09 | @ BOS | 91 | L 5-18 | 50-41 | 2 | 37,470 | Livan Hernandez | Josh Beckett | Josh Beckett | Livan Hernandez | | 446 | 431 | 15 |
| 2008-07-10 | @ DET | 92 | W 7-6 | 51-41 | 2 | 41,952 | Kevin Slowey | Kenny Rogers | Matt Guerrier | Freddy Dolsi | | 453 | 437 | 16 |
| 2008-07-11 | @ DET | 93 | W 3-2 | 52-41 | 2 | 42,352 | Glen Perkins | Armando Galarraga | Glen Perkins | Armando Galarraga | Joe Nathan | 456 | 439 | 17 |
| 2008-07-12 | @ DET | 94 | W 6-5 | 53-41 | 2 | 41,301 | Scott Baker | Nate Robertson | Scott Baker | Nate Robertson | Joe Nathan | 462 | 444 | 18 |
| 2008-07-13 | @ DET | 95 | L 2-4 | 53-42 | 2 | 41,453 | Nick Blackburn | Justin Verlander | Justin Verlander | Nick Blackburn | Todd Jones | 464 | 448 | 16 |
| 2008-07-18 | vs TEX | 96 | W 6-0 | 54-42 | 2 | 30,134 | Glen Perkins | Kevin Millwood | Glen Perkins | Kevin Millwood | | 470 | 448 | 22 |
| 2008-07-19 | vs TEX | 97 | W 14-2 | 55-42 | 2 | 35,085 | Livan Hernandez | Matt Harrison | Livan Hernandez | Matt Harrison | | 484 | 450 | 34 |
| 2008-07-20 | vs TEX | 98 | L 0-1 | 55-43 | 2 | 36,029 | Scott Baker | Vicente Padilla | Vicente Padilla | Scott Baker | C.J. Wilson | 484 | 451 | 33 |
| 2008-07-21 | @ NYA | 99 | L 4-12 | 55-44 | 2 | 53,484 | Nick Blackburn | Sidney Ponson | Sidney Ponson | Nick Blackburn | | 488 | 463 | 25 |
| 2008-07-22 | @ NYA | 100 | L 2-8 | 55-45 | 2 | 53,406 | Kevin Slowey | Darrell Rasner | David Robertson | Kevin Slowey | | 490 | 471 | 19 |
| 2008-07-23 | @ NYA | 101 | L 1-5 | 55-46 | 2 | 54,114 | Glen Perkins | Mike Mussina | Mike Mussina | Glen Perkins | Mariano Rivera | 491 | 476 | 15 |
| 2008-07-25 | @ CLE | 102 | L 4-5 | 55-47 | 2 | 33,512 | Livan Hernandez | Cliff Lee | Cliff Lee | Livan Hernandez | Rafael Perez | 495 | 481 | 14 |
| 2008-07-26 | @ CLE | 103 | W 11-4 | 56-47 | 2 | 35,390 | Scott Baker | Fausto Carmona | Scott Baker | Fausto Carmona | | 506 | 485 | 21 |
| 2008-07-27 | @ CLE | 104 | W 4-2 | 57-47 | 2 | 31,562 | Nick Blackburn | Jeremy Sowers | Matt Guerrier | Rafael Perez | Joe Nathan | 510 | 487 | 23 |
| 2008-07-28 | vs CHA | 105 | W 7-0 | 58-47 | 2 | 30,126 | Kevin Slowey | Mark Buehrle | Kevin Slowey | Mark Buehrle | | 517 | 487 | 30 |
| 2008-07-29 | vs CHA | 106 | W 6-5 | 59-47 | 2 | 35,999 | Glen Perkins | Clayton Richard | Glen Perkins | Clayton Richard | Joe Nathan | 523 | 492 | 31 |
| 2008-07-30 | vs CHA | 107 | L 3-8 | 59-48 | 2 | 42,705 | Livan Hernandez | Gavin Floyd | Gavin Floyd | Livan Hernandez | | 526 | 500 | 26 |
| 2008-07-31 | vs CHA | 108 | W 10-6 | 60-48 | 2 | 31,493 | Scott Baker | John Danks | Jesse Crain | Matt Thornton | | 536 | 506 | 30 |
| 2008-08-01 | vs CLE | 109 | W 4-1 | 61-48 | 2 | 33,709 | Nick Blackburn | Jeremy Sowers | Nick Blackburn | Jeremy Sowers | Joe Nathan | 540 | 507 | 33 |
| 2008-08-02 | vs CLE | 110 | L 1-5 | 61-49 | 2 | 40,937 | Kevin Slowey | Paul Byrd | Paul Byrd | Kevin Slowey | | 541 | 512 | 29 |
| 2008-08-03 | vs CLE | 111 | W 6-2 | 62-49 | 1 | 39,818 | Francisco Liriano | Matt Ginter | Francisco Liriano | Matt Ginter | | 547 | 514 | 33 |
| 2008-08-04 | @ SEA | 112 | L 6-11 | 62-50 | 1 | 27,758 | Glen Perkins | Miguel Batista | Roy Corcoran | Brian Bass | | 553 | 525 | 28 |
| 2008-08-05 | @ SEA | 113 | L 7-8 | 62-51 | 2 | 26,083 | Scott Baker | R.A. Dickey | J.J. Putz | Matt Guerrier | | 560 | 533 | 27 |
| 2008-08-06 | @ SEA | 114 | W 7-3 | 63-51 | 2 | 30,441 | Nick Blackburn | Jarrod Washburn | Nick Blackburn | Jarrod Washburn | | 567 | 536 | 31 |
| 2008-08-08 | @ KCA | 115 | W 4-1 | 64-51 | 2 | 33,653 | Kevin Slowey | Kyle Davies | Kevin Slowey | Kyle Davies | Joe Nathan | 571 | 537 | 34 |
| 2008-08-09 | @ KCA | 116 | W 7-3 | 65-51 | 1 | 27,960 | Francisco Liriano | Zack Greinke | Francisco Liriano | Zack Greinke | | 578 | 540 | 38 |
| 2008-08-10 | @ KCA | 117 | L 4-5 | 65-52 | 2 | 23,163 | Scott Baker | Gil Meche | Rob Tejeda | Craig Breslow | | 582 | 545 | 37 |
| 2008-08-11 | vs NYA | 118 | W 4-0 | 66-52 | 1 | 30,126 | Glen Perkins | Sidney Ponson | Glen Perkins | Sidney Ponson | | 586 | 545 | 41 |
| 2008-08-12 | vs NYA | 119 | L 6-9 | 66-53 | 2 | 33,036 | Nick Blackburn | Mike Mussina | Jose Veras | Matt Guerrier | Edwar Ramirez | 592 | 554 | 38 |
| 2008-08-13 | vs NYA | 120 | W 4-2 | 67-53 | 2 | 35,187 | Kevin Slowey | Darrell Rasner | Kevin Slowey | Darrell Rasner | Joe Nathan | 596 | 556 | 40 |
| 2008-08-15 | vs SEA | 121 | W 9-3 | 68-53 | 1 | 32,208 | Francisco Liriano | Carlos Silva | Francisco Liriano | Carlos Silva | | 605 | 559 | 46 |
| 2008-08-16 | vs SEA | 122 | W 7-6 | 69-53 | 1 | 36,316 | Scott Baker | Ryan Rowland-Smith | Dennys Reyes | Cesar Jimenez | | 612 | 565 | 47 |
| 2008-08-17 | vs SEA | 123 | W 11-8 | 70-53 | 1 | 35,478 | Glen Perkins | Ryan Feierabend | Glen Perkins | Ryan Feierabend | Joe Nathan | 623 | 573 | 50 |
| 2008-08-18 | vs OAK | 124 | L 2-3 | 70-54 | 2 | 25,024 | Nick Blackburn | Justin Duchscherer | Kirk Saarloos | Nick Blackburn | Brad Ziegler | 625 | 576 | 49 |
| 2008-08-19 | vs OAK | 125 | W 13-2 | 71-54 | 2 | 35,256 | Kevin Slowey | Sean Gallagher | Kevin Slowey | Sean Gallagher | | 638 | 578 | 60 |
| 2008-08-20 | vs OAK | 126 | W 3-1 | 72-54 | 2 | 30,888 | Francisco Liriano | Dallas Braden | Francisco Liriano | Dallas Braden | Joe Nathan | 641 | 579 | 62 |
| 2008-08-21 | @ ANA | 127 | W 2-1 | 73-54 | 2 | 41,367 | Scott Baker | John Lackey | Jesse Crain | Justin Speier | Joe Nathan | 643 | 580 | 63 |
| 2008-08-22 | @ ANA | 128 | W 9-0 | 74-54 | 1 | 43,819 | Glen Perkins | Joe Saunders | Glen Perkins | Joe Saunders | | 652 | 580 | 72 |
| 2008-08-23 | @ ANA | 129 | L 5-7 | 74-55 | 1 | 43,906 | Nick Blackburn | Jon Garland | Darren Oliver | Nick Blackburn | Francisco Rodriguez | 657 | 587 | 70 |
| 2008-08-24 | @ ANA | 130 | L 3-5 | 74-56 | 2 | 40,011 | Kevin Slowey | Ervin Santana | Jose Arredondo | Jesse Crain | Francisco Rodriguez | 660 | 592 | 68 |
| 2008-08-25 | @ SEA | 131 | L 2-4 | 74-57 | 2 | 23,277 | Francisco Liriano | Miguel Batista | R.A. Dickey | Jesse Crain | | 662 | 596 | 66 |
| 2008-08-26 | @ SEA | 132 | L 2-3 | 74-58 | 2 | 26,292 | Scott Baker | Ryan Rowland-Smith | Ryan Rowland-Smith | Scott Baker | Roy Corcoran | 664 | 599 | 65 |
| 2008-08-27 | @ SEA | 133 | W 6-5 | 75-58 | 2 | 23,581 | Glen Perkins | Ryan Feierabend | Glen Perkins | Sean Green | Joe Nathan | 670 | 604 | 66 |
| 2008-08-28 | @ OAK | 134 | L 2-3 | 75-59 | 2 | 12,357 | Nick Blackburn | Dana Eveland | Joey Devine | Craig Breslow | | 672 | 607 | 65 |
| 2008-08-29 | @ OAK | 135 | W 12-2 | 76-59 | 2 | 22,355 | Kevin Slowey | Dan Meyer | Kevin Slowey | Dan Meyer | Craig Breslow | 684 | 609 | 75 |
| 2008-08-30 | @ OAK | 136 | L 2-3 | 76-60 | 2 | 25,238 | Francisco Liriano | Dallas Braden | Huston Street | Joe Nathan | | 686 | 612 | 74 |
| 2008-08-31 | @ OAK | 137 | W 12-4 | 77-60 | 2 | 18,427 | Scott Baker | Greg Smith | Scott Baker | Greg Smith | | 698 | 616 | 82 |
| 2008-09-02 | @ TOR | 138 | L 5-7 | 77-61 | 2 | 21,254 | Glen Perkins | David Purcey | Jesse Carlson | Boof Bonser | B.J. Ryan | 703 | 623 | 80 |
| 2008-09-03 | @ TOR | 139 | L 4-5 | 77-62 | 2 | 21,475 | Nick Blackburn | A.J. Burnett | Jesse Carlson | Eddie Guardado | | 707 | 628 | 79 |
| 2008-09-04 | @ TOR | 140 | L 0-9 | 77-63 | 2 | 25,128 | Kevin Slowey | Jesse Litsch | Jesse Litsch | Kevin Slowey | | 707 | 637 | 70 |
| 2008-09-05 | vs DET | 141 | W 10-2 | 78-63 | 2 | 24,424 | Francisco Liriano | Armando Galarraga | Francisco Liriano | Armando Galarraga | | 717 | 639 | 78 |
| 2008-09-06 | vs DET | 142 | L 4-6 | 78-64 | 2 | 42,606 | Scott Baker | Justin Verlander | Clay Rapada | Matt Guerrier | Fernando Rodney | 721 | 645 | 76 |
| 2008-09-07 | vs DET | 143 | L 5-7 | 78-65 | 2 | 31,236 | Glen Perkins | Chris Lambert | Chris Lambert | Glen Perkins | Fernando Rodney | 726 | 652 | 74 |
| 2008-09-09 | vs KCA | 144 | W 7-2 | 79-65 | 2 | 17,015 | Nick Blackburn | Brian Bannister | Nick Blackburn | Brian Bannister | | 733 | 654 | 79 |
| 2008-09-10 | vs KCA | 145 | W 7-1 | 80-65 | 2 | 20,421 | Kevin Slowey | Kyle Davies | Kevin Slowey | Kyle Davies | | 740 | 655 | 85 |
| 2008-09-11 | vs KCA | 146 | L 2-3 | 80-66 | 2 | 20,138 | Francisco Liriano | Brandon Duckworth | Ramon Ramirez | Matt Guerrier | Joakim Soria | 742 | 658 | 84 |
| 2008-09-13 | @ BAL | 147 | W 12-2 | 82-66 | 2 | 0 | Scott Baker | Daniel Cabrera | Scott Baker | Daniel Cabrera | | 754 | 660 | 94 |
| 2008-09-13 | @ BAL | 148 | W 12-6 | 82-66 | 2 | 21,712 | Glen Perkins | Garrett Olson | Bobby Korecky | Garrett Olson | | 766 | 666 | 100 |
| 2008-09-14 | @ BAL | 149 | L 3-7 | 82-67 | 2 | 18,559 | Nick Blackburn | Radhames Liz | Radhames Liz | Nick Blackburn | | 769 | 673 | 96 |
| 2008-09-15 | @ CLE | 150 | L 1-3 | 82-68 | 2 | 19,607 | Kevin Slowey | Scott Lewis | Scott Lewis | Kevin Slowey | Jensen Lewis | 770 | 676 | 94 |
| 2008-09-16 | @ CLE | 151 | L 9-12 | 82-69 | 2 | 21,295 | Francisco Liriano | Zach Jackson | Tom Mastny | Joe Nathan | | 779 | 688 | 91 |
| 2008-09-17 | @ CLE | 152 | L 4-6 | 82-70 | 2 | 22,904 | Scott Baker | Cliff Lee | Edward Mujica | Jose Mijares | Jensen Lewis | 783 | 694 | 89 |
| 2008-09-18 | @ TBA | 153 | W 11-8 | 83-70 | 2 | 17,296 | Glen Perkins | James Shields | Eddie Guardado | Dan Wheeler | Joe Nathan | 794 | 702 | 92 |
| 2008-09-19 | @ TBA | 154 | L 1-11 | 83-71 | 2 | 28,306 | Nick Blackburn | Edwin Jackson | Edwin Jackson | Nick Blackburn | | 795 | 713 | 82 |
| 2008-09-20 | @ TBA | 155 | L 2-7 | 83-72 | 2 | 36,048 | Kevin Slowey | Scott Kazmir | Scott Kazmir | Kevin Slowey | | 797 | 720 | 77 |
| 2008-09-21 | @ TBA | 156 | W 4-1 | 84-72 | 2 | 36,048 | Francisco Liriano | Andy Sonnanstine | Francisco Liriano | Andy Sonnanstine | Joe Nathan | 801 | 721 | 80 |
| 2008-09-23 | vs CHA | 157 | W 9-3 | 85-72 | 2 | 35,225 | Scott Baker | Javier Vazquez | Scott Baker | Javier Vazquez | | 810 | 724 | 86 |
| 2008-09-24 | vs CHA | 158 | W 3-2 | 86-72 | 2 | 42,126 | Nick Blackburn | Mark Buehrle | Nick Blackburn | Mark Buehrle | Joe Nathan | 813 | 726 | 87 |
| 2008-09-25 | vs CHA | 159 | W 7-6 | 87-72 | 1 | 43,601 | Kevin Slowey | Gavin Floyd | Joe Nathan | Bobby Jenks | | 820 | 732 | 88 |
| 2008-09-26 | vs KCA | 160 | L 1-8 | 87-73 | 1 | 30,674 | Francisco Liriano | Kyle Davies | Kyle Davies | Francisco Liriano | | 821 | 740 | 81 |
| 2008-09-27 | vs KCA | 161 | L 2-4 | 87-74 | 1 | 38,072 | Glen Perkins | Gil Meche | Gil Meche | Matt Guerrier | Joakim Soria | 823 | 744 | 79 |
| 2008-09-28 | vs KCA | 162 | W 6-0 | 88-74 | 1 | 42,942 | Scott Baker | Brandon Duckworth | Scott Baker | Brandon Duckworth | | 829 | 744 | 85 |
| 2008-09-30 | @ CHA | 163 | L 0-1 | 88-75 | 2 | 40,354 | Nick Blackburn | John Danks | John Danks | Nick Blackburn | Bobby Jenks | 829 | 745 | 84 |