| 2008-03-31 | @ CHN | 1 | W 4-3 | 1-0 | 1 | 41,089 | Ben Sheets | Carlos Zambrano | Eric Gagne | Bob Howry | David Riske | 4 | 3 | 1 |
| 2008-04-02 | @ CHN | 2 | W 8-2 | 2-0 | 1 | 39,468 | Jeff Suppan | Ted Lilly | Jeff Suppan | Ted Lilly | | 12 | 5 | 7 |
| 2008-04-03 | @ CHN | 3 | L 3-6 | 2-1 | 2 | 37,973 | David Bush | Ryan Dempster | Ryan Dempster | David Bush | Kerry Wood | 15 | 11 | 4 |
| 2008-04-04 | vs SFN | 4 | W 13-4 | 3-1 | 1 | 45,212 | Carlos Villanueva | Jonathan Sanchez | Carlos Villanueva | Jonathan Sanchez | Salomon Torres | 28 | 15 | 13 |
| 2008-04-05 | vs SFN | 5 | W 5-4 | 4-1 | 1 | 30,574 | Manny Parra | Kevin Correia | Manny Parra | Kevin Correia | Eric Gagne | 33 | 19 | 14 |
| 2008-04-06 | vs SFN | 6 | W 7-0 | 5-1 | 1 | 44,014 | Ben Sheets | Barry Zito | Ben Sheets | Barry Zito | | 40 | 19 | 21 |
| 2008-04-08 | vs CIN | 7 | W 3-2 | 6-1 | 1 | 27,717 | Jeff Suppan | Johnny Cueto | Salomon Torres | David Weathers | | 43 | 21 | 22 |
| 2008-04-09 | vs CIN | 8 | L 4-12 | 6-2 | 2 | 31,313 | David Bush | Josh Fogg | Josh Fogg | David Bush | | 47 | 33 | 14 |
| 2008-04-10 | vs CIN | 9 | L 1-4 | 6-3 | 3 | 25,023 | Carlos Villanueva | Aaron Harang | Aaron Harang | Carlos Villanueva | Francisco Cordero | 48 | 37 | 11 |
| 2008-04-11 | @ NYN | 10 | L 2-4 | 6-4 | 3 | 46,214 | Manny Parra | Nelson Figueroa | Nelson Figueroa | Manny Parra | Billy Wagner | 50 | 41 | 9 |
| 2008-04-12 | @ NYN | 11 | W 5-3 | 7-4 | 2 | 54,701 | Ben Sheets | Johan Santana | Ben Sheets | Johan Santana | Eric Gagne | 55 | 44 | 11 |
| 2008-04-13 | @ NYN | 12 | W 9-7 | 8-4 | 2 | 52,794 | Jeff Suppan | Oliver Perez | Salomon Torres | Jorge Sosa | Eric Gagne | 64 | 51 | 13 |
| 2008-04-15 | @ SLN | 13 | L 1-6 | 8-5 | 3 | 39,438 | David Bush | Braden Looper | Braden Looper | David Bush | | 65 | 57 | 8 |
| 2008-04-16 | @ SLN | 14 | L 4-5 | 8-6 | 3 | 40,712 | Carlos Villanueva | Adam Wainwright | Adam Wainwright | Carlos Villanueva | Jason Isringhausen | 69 | 62 | 7 |
| 2008-04-17 | @ SLN | 15 | W 5-3 | 9-6 | 3 | 36,850 | Manny Parra | Kyle Lohse | Brian Shouse | Brad Thompson | Eric Gagne | 74 | 65 | 9 |
| 2008-04-18 | @ CIN | 16 | W 5-2 | 10-6 | 3 | 32,629 | Ben Sheets | Bronson Arroyo | Ben Sheets | Bronson Arroyo | Eric Gagne | 79 | 67 | 12 |
| 2008-04-19 | @ CIN | 17 | W 5-3 | 11-6 | 3 | 26,410 | Jeff Suppan | Johnny Cueto | Guillermo Mota | David Weathers | Eric Gagne | 84 | 70 | 14 |
| 2008-04-20 | @ CIN | 18 | L 3-4 | 11-7 | 3 | 26,902 | Yovani Gallardo | Aaron Harang | Jared Burton | Eric Gagne | | 87 | 74 | 13 |
| 2008-04-21 | vs SLN | 19 | L 3-4 | 11-8 | 3 | 31,240 | Carlos Villanueva | Adam Wainwright | Ryan Franklin | Derrick Turnbow | Jason Isringhausen | 90 | 78 | 12 |
| 2008-04-22 | vs SLN | 20 | W 9-8 | 12-8 | 3 | 23,748 | Manny Parra | Kyle Lohse | Seth McClung | Jason Isringhausen | | 99 | 86 | 13 |
| 2008-04-23 | vs PHI | 21 | W 5-4 | 13-8 | 2 | 30,548 | David Bush | Cole Hamels | Mitch Stetter | Cole Hamels | Derrick Turnbow | 104 | 90 | 14 |
| 2008-04-24 | vs PHI | 22 | L 1-3 | 13-9 | 3 | 23,905 | Jeff Suppan | Jamie Moyer | Tom Gordon | David Riske | Brad Lidge | 105 | 93 | 12 |
| 2008-04-25 | vs FLO | 23 | L 0-3 | 13-10 | 3 | 40,088 | Yovani Gallardo | Scott Olsen | Kevin Gregg | Guillermo Mota | | 105 | 96 | 9 |
| 2008-04-26 | vs FLO | 24 | W 4-3 | 14-10 | 3 | 44,169 | Carlos Villanueva | Mark Hendrickson | Salomon Torres | Renyel Pinto | Eric Gagne | 109 | 99 | 10 |
| 2008-04-27 | vs FLO | 25 | L 2-3 | 14-11 | 3 | 41,656 | Manny Parra | Ricky Nolasco | Matt Lindstrom | Seth McClung | Kevin Gregg | 111 | 102 | 9 |
| 2008-04-29 | @ CHN | 26 | W 10-7 | 15-11 | 3 | 39,543 | Ben Sheets | Jason Marquis | Ben Sheets | Jason Marquis | Eric Gagne | 121 | 109 | 12 |
| 2008-04-30 | @ CHN | 27 | L 5-19 | 15-12 | 3 | 39,908 | Jeff Suppan | Ryan Dempster | Ryan Dempster | Jeff Suppan | | 126 | 128 | -2 |
| 2008-05-01 | @ CHN | 28 | W 4-3 | 16-12 | 3 | 40,849 | Yovani Gallardo | Carlos Zambrano | Brian Shouse | Kerry Wood | Eric Gagne | 130 | 131 | -1 |
| 2008-05-02 | @ HOU | 29 | L 4-7 | 16-13 | 3 | 39,715 | Carlos Villanueva | Roy Oswalt | Roy Oswalt | Carlos Villanueva | Jose Valverde | 134 | 138 | -4 |
| 2008-05-03 | @ HOU | 30 | L 2-6 | 16-14 | 3 | 35,002 | Manny Parra | Brandon Backe | Brandon Backe | Manny Parra | | 136 | 144 | -8 |
| 2008-05-04 | @ HOU | 31 | L 6-8 | 16-15 | 3 | 38,301 | Ben Sheets | Chris Sampson | Tim Byrdak | Mitch Stetter | | 142 | 152 | -10 |
| 2008-05-06 | @ FLO | 32 | L 0-3 | 16-16 | 4 | 10,113 | Jeff Suppan | Scott Olsen | Scott Olsen | Jeff Suppan | Kevin Gregg | 142 | 155 | -13 |
| 2008-05-07 | @ FLO | 33 | L 2-6 | 16-17 | 4 | 10,405 | David Bush | Burke Badenhop | Burke Badenhop | David Bush | | 144 | 161 | -17 |
| 2008-05-08 | @ FLO | 34 | L 2-7 | 16-18 | 4 | 12,321 | Carlos Villanueva | Mark Hendrickson | Logan Kensing | Carlos Villanueva | | 146 | 168 | -22 |
| 2008-05-09 | vs SLN | 35 | W 4-3 | 17-18 | 4 | 42,705 | Manny Parra | Todd Wellemeyer | Brian Shouse | Jason Isringhausen | | 150 | 171 | -21 |
| 2008-05-10 | vs SLN | 36 | L 3-5 | 17-19 | 4 | 43,382 | Ben Sheets | Joel Pineiro | Russ Springer | Eric Gagne | Ryan Franklin | 153 | 176 | -23 |
| 2008-05-11 | vs SLN | 37 | W 5-3 | 18-19 | 4 | 41,197 | Jeff Suppan | Braden Looper | Jeff Suppan | Braden Looper | Brian Shouse | 158 | 179 | -21 |
| 2008-05-12 | vs SLN | 38 | W 8-3 | 19-19 | 4 | 25,757 | David Bush | Adam Wainwright | David Bush | Adam Wainwright | Guillermo Mota | 166 | 182 | -16 |
| 2008-05-13 | vs LAN | 39 | W 5-3 | 20-19 | 4 | 26,465 | Carlos Villanueva | Brad Penny | Carlos Villanueva | Brad Penny | Eric Gagne | 171 | 185 | -14 |
| 2008-05-14 | vs LAN | 40 | L 4-6 | 20-20 | 4 | 27,562 | Manny Parra | Derek Lowe | Jonathan Broxton | Guillermo Mota | Takashi Saito | 175 | 191 | -16 |
| 2008-05-15 | vs LAN | 41 | L 2-7 | 20-21 | 4 | 30,444 | Ben Sheets | Chad Billingsley | Chad Billingsley | Ben Sheets | | 177 | 198 | -21 |
| 2008-05-17 | @ BOS | 42 | L 3-5 | 20-23 | 6 | 37,409 | Jeff Suppan | Daisuke Matsuzaka | Daisuke Matsuzaka | Jeff Suppan | Jonathan Papelbon | 180 | 203 | -23 |
| 2008-05-17 | @ BOS | 43 | L 6-7 | 20-23 | 6 | 37,847 | David Bush | Tim Wakefield | Craig Hansen | Salomon Torres | Mike Timlin | 186 | 210 | -24 |
| 2008-05-18 | @ BOS | 44 | L 7-11 | 20-24 | 6 | 37,204 | Carlos Villanueva | Josh Beckett | Josh Beckett | Carlos Villanueva | | 193 | 221 | -28 |
| 2008-05-20 | @ PIT | 45 | W 7-2 | 21-24 | 4 | 11,761 | Manny Parra | Paul Maholm | Manny Parra | Paul Maholm | | 200 | 223 | -23 |
| 2008-05-21 | @ PIT | 46 | W 4-1 | 22-24 | 4 | 8,805 | Ben Sheets | Ian Snell | Ben Sheets | Ian Snell | | 204 | 224 | -20 |
| 2008-05-22 | @ PIT | 47 | L 4-8 | 22-25 | 4 | 12,887 | David Bush | Tom Gorzelanny | Tom Gorzelanny | David Bush | | 208 | 232 | -24 |
| 2008-05-23 | @ WAS | 48 | L 1-5 | 22-26 | 4 | 28,007 | Jeff Suppan | Odalis Perez | Brian Sanches | Jeff Suppan | | 209 | 237 | -28 |
| 2008-05-24 | @ WAS | 49 | W 5-2 | 23-26 | 4 | 30,029 | Seth McClung | John Lannan | Seth McClung | John Lannan | Salomon Torres | 214 | 239 | -25 |
| 2008-05-25 | @ WAS | 50 | L 6-7 | 23-27 | 5 | 35,567 | Manny Parra | Tim Redding | Jon Rauch | Guillermo Mota | | 220 | 246 | -26 |
| 2008-05-26 | @ WAS | 51 | W 4-3 | 24-27 | 5 | 28,552 | Ben Sheets | Jason Bergmann | Carlos Villanueva | Saul Rivera | Salomon Torres | 224 | 249 | -25 |
| 2008-05-27 | vs ATL | 52 | W 3-2 | 25-27 | 4 | 28,872 | David Bush | Tim Hudson | Salomon Torres | Jeff Bennett | | 227 | 251 | -24 |
| 2008-05-28 | vs ATL | 53 | W 1-0 | 26-27 | 4 | 31,612 | Jeff Suppan | Jo-Jo Reyes | Jeff Suppan | Jo-Jo Reyes | Salomon Torres | 228 | 251 | -23 |
| 2008-05-29 | vs ATL | 54 | L 1-8 | 26-28 | 4 | 33,334 | Seth McClung | Jorge Campillo | Jorge Campillo | Seth McClung | | 229 | 259 | -30 |
| 2008-05-30 | vs HOU | 55 | W 5-1 | 27-28 | 4 | 32,039 | Manny Parra | Brandon Backe | Manny Parra | Brandon Backe | | 234 | 260 | -26 |
| 2008-05-31 | vs HOU | 56 | W 4-1 | 28-28 | 4 | 42,913 | Ben Sheets | Brian Moehler | Ben Sheets | Brian Moehler | Salomon Torres | 238 | 261 | -23 |
| 2008-06-01 | vs HOU | 57 | W 10-1 | 29-28 | 4 | 44,613 | David Bush | Shawn Chacon | David Bush | Shawn Chacon | | 248 | 262 | -14 |
| 2008-06-02 | vs ARI | 58 | W 4-3 | 30-28 | 4 | 27,562 | Jeff Suppan | Doug Davis | Guillermo Mota | Doug Slaten | Salomon Torres | 252 | 265 | -13 |
| 2008-06-03 | vs ARI | 59 | W 7-1 | 31-28 | 4 | 29,478 | Seth McClung | Randy Johnson | Seth McClung | Randy Johnson | Brian Shouse | 259 | 266 | -7 |
| 2008-06-04 | vs ARI | 60 | W 10-1 | 32-28 | 3 | 27,539 | Manny Parra | Micah Owings | Manny Parra | Micah Owings | | 269 | 267 | 2 |
| 2008-06-06 | @ COL | 61 | L 4-6 | 32-29 | 3 | 30,558 | Ben Sheets | Ubaldo Jimenez | Manuel Corpas | Guillermo Mota | Brian Fuentes | 273 | 273 | 0 |
| 2008-06-07 | @ COL | 62 | L 2-7 | 32-30 | 3 | 37,283 | David Bush | Greg Reynolds | Greg Reynolds | David Bush | | 275 | 280 | -5 |
| 2008-06-08 | @ COL | 63 | W 3-2 | 33-30 | 3 | 32,256 | Jeff Suppan | Jeff Francis | Jeff Suppan | Jeff Francis | Salomon Torres | 278 | 282 | -4 |
| 2008-06-10 | @ HOU | 64 | L 1-6 | 33-31 | 3 | 35,058 | Seth McClung | Roy Oswalt | Roy Oswalt | Seth McClung | | 279 | 288 | -9 |
| 2008-06-11 | @ HOU | 65 | W 10-6 | 34-31 | 3 | 33,806 | Manny Parra | Brandon Backe | Manny Parra | Brandon Backe | | 289 | 294 | -5 |
| 2008-06-12 | @ HOU | 66 | W 9-6 | 35-31 | 3 | 35,709 | Ben Sheets | Brian Moehler | Ben Sheets | Brian Moehler | | 298 | 300 | -2 |
| 2008-06-13 | vs MIN | 67 | L 2-10 | 35-32 | 3 | 38,586 | David Bush | Kevin Slowey | Kevin Slowey | David Bush | | 300 | 310 | -10 |
| 2008-06-14 | vs MIN | 68 | L 4-9 | 35-33 | 3 | 43,812 | Jeff Suppan | Glen Perkins | Brian Bass | Julian Tavarez | | 304 | 319 | -15 |
| 2008-06-15 | vs MIN | 69 | W 4-2 | 36-33 | 3 | 41,693 | Seth McClung | Scott Baker | Seth McClung | Scott Baker | Salomon Torres | 308 | 321 | -13 |
| 2008-06-17 | vs TOR | 70 | W 7-0 | 37-33 | 3 | 37,065 | Manny Parra | Dustin McGowan | Manny Parra | Dustin McGowan | | 315 | 321 | -6 |
| 2008-06-18 | vs TOR | 71 | W 5-4 | 38-33 | 3 | 34,442 | Ben Sheets | Shaun Marcum | Ben Sheets | Shaun Marcum | Salomon Torres | 320 | 325 | -5 |
| 2008-06-19 | vs TOR | 72 | W 8-7 | 39-33 | 3 | 35,173 | David Bush | A.J. Burnett | David Bush | A.J. Burnett | Salomon Torres | 328 | 332 | -4 |
| 2008-06-20 | vs BAL | 73 | L 5-8 | 39-34 | 3 | 36,526 | Jeff Suppan | Radhames Liz | Lance Cormier | Jeff Suppan | George Sherrill | 333 | 340 | -7 |
| 2008-06-21 | vs BAL | 74 | W 3-2 | 40-34 | 3 | 42,521 | Seth McClung | Daniel Cabrera | Seth McClung | Daniel Cabrera | Salomon Torres | 336 | 342 | -6 |
| 2008-06-22 | vs BAL | 75 | W 7-3 | 41-34 | 3 | 43,517 | Manny Parra | Garrett Olson | Manny Parra | Garrett Olson | Salomon Torres | 343 | 345 | -2 |
| 2008-06-23 | @ ATL | 76 | W 4-1 | 42-34 | 3 | 25,661 | Ben Sheets | Jo-Jo Reyes | Ben Sheets | Jo-Jo Reyes | | 347 | 346 | 1 |
| 2008-06-24 | @ ATL | 77 | W 4-3 | 43-34 | 3 | 29,224 | David Bush | Charlie Morton | David Bush | Charlie Morton | Salomon Torres | 351 | 349 | 2 |
| 2008-06-25 | @ ATL | 78 | L 2-4 | 43-35 | 3 | 34,829 | Jeff Suppan | Jorge Campillo | Jorge Campillo | Jeff Suppan | Mike Gonzalez | 353 | 353 | 0 |
| 2008-06-27 | @ MIN | 79 | L 6-7 | 43-36 | 3 | 30,104 | Seth McClung | Nick Blackburn | Matt Guerrier | Guillermo Mota | Joe Nathan | 359 | 360 | -1 |
| 2008-06-28 | @ MIN | 80 | W 5-1 | 44-36 | 3 | 38,963 | Manny Parra | Livan Hernandez | Manny Parra | Livan Hernandez | | 364 | 361 | 3 |
| 2008-06-29 | @ MIN | 81 | L 0-5 | 44-37 | 3 | 30,655 | Ben Sheets | Kevin Slowey | Kevin Slowey | Ben Sheets | | 364 | 366 | -2 |
| 2008-06-30 | @ ARI | 82 | L 3-6 | 44-38 | 3 | 23,040 | David Bush | Doug Davis | Doug Davis | David Bush | Brandon Lyon | 367 | 372 | -5 |
| 2008-07-01 | @ ARI | 83 | W 8-6 | 45-38 | 3 | 21,736 | Jeff Suppan | Randy Johnson | Jeff Suppan | Randy Johnson | Salomon Torres | 375 | 378 | -3 |
| 2008-07-02 | @ ARI | 84 | W 4-3 | 46-38 | 3 | 22,324 | Seth McClung | Yusmeiro Petit | David Riske | Brandon Lyon | Salomon Torres | 379 | 381 | -2 |
| 2008-07-03 | @ ARI | 85 | L 5-6 | 46-39 | 3 | 23,842 | Manny Parra | Brandon Webb | Leo Rosales | Salomon Torres | | 384 | 387 | -3 |
| 2008-07-04 | vs PIT | 86 | W 9-1 | 47-39 | 3 | 41,463 | Ben Sheets | Tom Gorzelanny | Ben Sheets | Tom Gorzelanny | Carlos Villanueva | 393 | 388 | 5 |
| 2008-07-05 | vs PIT | 87 | W 2-1 | 48-39 | 3 | 39,176 | David Bush | Paul Maholm | Eric Gagne | Tyler Yates | | 395 | 389 | 6 |
| 2008-07-06 | vs PIT | 88 | W 11-6 | 49-39 | 2 | 42,163 | Jeff Suppan | Zach Duke | Mitch Stetter | Denny Bautista | | 406 | 395 | 11 |
| 2008-07-07 | vs COL | 89 | L 3-4 | 49-40 | 3 | 35,161 | Seth McClung | Ubaldo Jimenez | Ubaldo Jimenez | Seth McClung | Brian Fuentes | 409 | 399 | 10 |
| 2008-07-08 | vs COL | 90 | W 7-3 | 50-40 | 3 | 42,533 | CC Sabathia | Mark Redman | CC Sabathia | Mark Redman | | 416 | 402 | 14 |
| 2008-07-09 | vs COL | 91 | L 3-8 | 50-41 | 3 | 37,092 | Ben Sheets | Glendon Rusch | Glendon Rusch | Ben Sheets | | 419 | 410 | 9 |
| 2008-07-10 | vs COL | 92 | W 11-1 | 51-41 | 2 | 43,389 | David Bush | Jorge de la Rosa | David Bush | Jorge de la Rosa | | 430 | 411 | 19 |
| 2008-07-11 | vs CIN | 93 | L 5-6 | 51-42 | 3 | 41,229 | Manny Parra | Josh Fogg | Mike Lincoln | Brian Shouse | Francisco Cordero | 435 | 417 | 18 |
| 2008-07-12 | vs CIN | 94 | L 2-8 | 51-43 | 3 | 43,556 | Seth McClung | Edinson Volquez | Edinson Volquez | Seth McClung | | 437 | 425 | 12 |
| 2008-07-13 | vs CIN | 95 | W 3-2 | 52-43 | 3 | 42,108 | CC Sabathia | Homer Bailey | CC Sabathia | David Weathers | | 440 | 427 | 13 |
| 2008-07-18 | @ SFN | 96 | W 9-1 | 53-43 | 3 | 40,882 | CC Sabathia | Matt Cain | CC Sabathia | Matt Cain | | 449 | 428 | 21 |
| 2008-07-19 | @ SFN | 97 | W 8-5 | 54-43 | 3 | 36,852 | Ben Sheets | Jonathan Sanchez | Carlos Villanueva | Osiris Matos | Salomon Torres | 457 | 433 | 24 |
| 2008-07-20 | @ SFN | 98 | W 7-4 | 55-43 | 3 | 37,507 | Manny Parra | Tim Lincecum | Manny Parra | Tim Lincecum | Salomon Torres | 464 | 437 | 27 |
| 2008-07-21 | @ SLN | 99 | W 6-3 | 56-43 | 2 | 41,006 | Seth McClung | Joel Pineiro | Salomon Torres | Ryan Franklin | | 470 | 440 | 30 |
| 2008-07-22 | @ SLN | 100 | W 4-3 | 57-43 | 2 | 41,955 | Jeff Suppan | Kyle Lohse | Brian Shouse | Kyle McClellan | Salomon Torres | 474 | 443 | 31 |
| 2008-07-23 | @ SLN | 101 | W 3-0 | 58-43 | 2 | 41,513 | CC Sabathia | Braden Looper | CC Sabathia | Braden Looper | | 477 | 443 | 34 |
| 2008-07-24 | @ SLN | 102 | W 4-3 | 59-43 | 2 | 41,233 | Ben Sheets | Todd Wellemeyer | Eric Gagne | Ryan Franklin | Salomon Torres | 481 | 446 | 35 |
| 2008-07-25 | vs HOU | 103 | L 1-3 | 59-44 | 2 | 41,357 | Manny Parra | Wandy Rodriguez | Wandy Rodriguez | Manny Parra | Jose Valverde | 482 | 449 | 33 |
| 2008-07-26 | vs HOU | 104 | W 6-4 | 60-44 | 2 | 43,489 | David Bush | Brandon Backe | Eric Gagne | Doug Brocail | Salomon Torres | 488 | 453 | 35 |
| 2008-07-27 | vs HOU | 105 | L 6-11 | 60-45 | 2 | 41,565 | Jeff Suppan | Randy Wolf | Chris Sampson | Jeff Suppan | | 494 | 464 | 30 |
| 2008-07-28 | vs CHN | 106 | L 4-6 | 60-46 | 2 | 45,311 | CC Sabathia | Ted Lilly | Chad Gaudin | Salomon Torres | Carlos Marmol | 498 | 470 | 28 |
| 2008-07-29 | vs CHN | 107 | L 1-7 | 60-47 | 2 | 45,069 | Ben Sheets | Carlos Zambrano | Carlos Zambrano | Ben Sheets | | 499 | 477 | 22 |
| 2008-07-30 | vs CHN | 108 | L 2-7 | 60-48 | 2 | 44,871 | Manny Parra | Ryan Dempster | Ryan Dempster | Manny Parra | | 501 | 484 | 17 |
| 2008-07-31 | vs CHN | 109 | L 4-11 | 60-49 | 2 | 45,346 | David Bush | Rich Harden | Rich Harden | David Bush | | 505 | 495 | 10 |
| 2008-08-01 | @ ATL | 110 | W 9-0 | 61-49 | 2 | 32,238 | Jeff Suppan | Chuck James | Jeff Suppan | Chuck James | | 514 | 495 | 19 |
| 2008-08-02 | @ ATL | 111 | W 4-2 | 62-49 | 2 | 42,096 | CC Sabathia | Charlie Morton | CC Sabathia | Charlie Morton | Salomon Torres | 518 | 497 | 21 |
| 2008-08-03 | @ ATL | 112 | L 0-5 | 62-50 | 2 | 29,177 | Ben Sheets | Jorge Campillo | Jorge Campillo | Ben Sheets | | 518 | 502 | 16 |
| 2008-08-04 | @ CIN | 113 | L 3-6 | 62-51 | 2 | 24,706 | Manny Parra | Bronson Arroyo | Bronson Arroyo | Manny Parra | Francisco Cordero | 521 | 508 | 13 |
| 2008-08-05 | @ CIN | 114 | W 8-1 | 63-51 | 2 | 24,739 | David Bush | Edinson Volquez | David Bush | Edinson Volquez | | 529 | 509 | 20 |
| 2008-08-06 | @ CIN | 115 | W 6-3 | 64-51 | 2 | 26,602 | Jeff Suppan | Homer Bailey | Jeff Suppan | Homer Bailey | Salomon Torres | 535 | 512 | 23 |
| 2008-08-08 | vs WAS | 116 | W 5-0 | 65-51 | 2 | 43,209 | CC Sabathia | Collin Balester | CC Sabathia | Collin Balester | | 540 | 512 | 28 |
| 2008-08-09 | vs WAS | 117 | W 6-0 | 66-51 | 2 | 42,974 | Ben Sheets | Tim Redding | Ben Sheets | Tim Redding | | 546 | 512 | 34 |
| 2008-08-10 | vs WAS | 118 | W 5-4 | 67-51 | 2 | 42,423 | Manny Parra | John Lannan | Guillermo Mota | Luis Ayala | | 551 | 516 | 35 |
| 2008-08-11 | vs WAS | 119 | W 7-1 | 68-51 | 2 | 42,196 | David Bush | Garrett Mock | David Bush | Garrett Mock | | 558 | 517 | 41 |
| 2008-08-12 | @ SDN | 120 | W 5-2 | 69-51 | 2 | 28,373 | Jeff Suppan | Cha-Seung Baek | Jeff Suppan | Cha-Seung Baek | Salomon Torres | 563 | 519 | 44 |
| 2008-08-13 | @ SDN | 121 | W 7-1 | 70-51 | 2 | 32,771 | CC Sabathia | Josh Banks | CC Sabathia | Josh Banks | | 570 | 520 | 50 |
| 2008-08-14 | @ SDN | 122 | L 2-3 | 70-52 | 2 | 30,145 | Ben Sheets | Jake Peavy | Jake Peavy | Ben Sheets | Trevor Hoffman | 572 | 523 | 49 |
| 2008-08-15 | @ LAN | 123 | L 3-5 | 70-53 | 2 | 44,547 | Manny Parra | Chad Billingsley | Chad Billingsley | Manny Parra | Jonathan Broxton | 575 | 528 | 47 |
| 2008-08-16 | @ LAN | 124 | W 4-3 | 71-53 | 2 | 52,889 | David Bush | Derek Lowe | Salomon Torres | Jonathan Broxton | David Riske | 579 | 531 | 48 |
| 2008-08-17 | @ LAN | 125 | L 5-7 | 71-54 | 2 | 45,267 | Jeff Suppan | Clayton Kershaw | Joe Beimel | Carlos Villanueva | | 584 | 538 | 46 |
| 2008-08-18 | vs HOU | 126 | W 9-3 | 72-54 | 2 | 41,991 | CC Sabathia | Randy Wolf | CC Sabathia | Randy Wolf | | 593 | 541 | 52 |
| 2008-08-19 | vs HOU | 127 | L 2-5 | 72-55 | 2 | 41,622 | Ben Sheets | Brian Moehler | Brian Moehler | Ben Sheets | Jose Valverde | 595 | 546 | 49 |
| 2008-08-20 | vs HOU | 128 | W 5-2 | 73-55 | 2 | 41,419 | Manny Parra | Wandy Rodriguez | Manny Parra | Wandy Rodriguez | Salomon Torres | 600 | 548 | 52 |
| 2008-08-22 | vs PIT | 129 | W 10-4 | 74-55 | 2 | 41,637 | David Bush | Zach Duke | David Bush | Zach Duke | | 610 | 552 | 58 |
| 2008-08-23 | vs PIT | 130 | W 6-3 | 75-55 | 2 | 43,293 | Jeff Suppan | Tom Gorzelanny | Jeff Suppan | Tom Gorzelanny | Salomon Torres | 616 | 555 | 61 |
| 2008-08-24 | vs PIT | 131 | W 4-3 | 76-55 | 2 | 45,163 | CC Sabathia | Paul Maholm | Guillermo Mota | Jason Davis | | 620 | 558 | 62 |
| 2008-08-26 | @ SLN | 132 | W 12-0 | 77-55 | 2 | 41,121 | Ben Sheets | Todd Wellemeyer | Ben Sheets | Todd Wellemeyer | | 632 | 558 | 74 |
| 2008-08-27 | @ SLN | 133 | L 3-5 | 77-56 | 2 | 41,433 | Manny Parra | Adam Wainwright | Ryan Franklin | David Riske | Chris Perez | 635 | 563 | 72 |
| 2008-08-29 | @ PIT | 134 | W 3-1 | 78-56 | 2 | 18,086 | David Bush | Tom Gorzelanny | David Bush | Tom Gorzelanny | Salomon Torres | 638 | 564 | 74 |
| 2008-08-30 | @ PIT | 135 | W 11-3 | 79-56 | 2 | 21,931 | Jeff Suppan | Paul Maholm | Jeff Suppan | Paul Maholm | | 649 | 567 | 82 |
| 2008-08-31 | @ PIT | 136 | W 7-0 | 80-56 | 2 | 21,293 | CC Sabathia | Jeff Karstens | CC Sabathia | Jeff Karstens | | 656 | 567 | 89 |
| 2008-09-01 | vs NYN | 137 | L 2-4 | 80-57 | 2 | 41,476 | Ben Sheets | Johan Santana | Nelson Figueroa | Eric Gagne | Luis Ayala | 658 | 571 | 87 |
| 2008-09-02 | vs NYN | 138 | L 5-6 | 80-58 | 2 | 36,587 | Manny Parra | Jonathon Niese | Joe Smith | Salomon Torres | Luis Ayala | 663 | 577 | 86 |
| 2008-09-03 | vs NYN | 139 | L 2-9 | 80-59 | 2 | 26,236 | David Bush | Oliver Perez | Oliver Perez | David Bush | | 665 | 586 | 79 |
| 2008-09-04 | vs SDN | 140 | L 2-5 | 80-60 | 2 | 33,182 | Jeff Suppan | Shawn Estes | Shawn Estes | Jeff Suppan | Trevor Hoffman | 667 | 591 | 76 |
| 2008-09-05 | vs SDN | 141 | W 3-2 | 81-60 | 2 | 41,519 | CC Sabathia | Josh Geer | Brian Shouse | Brian Falkenborg | | 670 | 593 | 77 |
| 2008-09-06 | vs SDN | 142 | W 1-0 | 82-60 | 2 | 42,667 | Ben Sheets | Jake Peavy | Ben Sheets | Jake Peavy | | 671 | 593 | 78 |
| 2008-09-07 | vs SDN | 143 | L 1-10 | 82-61 | 2 | 44,568 | Manny Parra | Chris Young | Chris Young | Manny Parra | | 672 | 603 | 69 |
| 2008-09-08 | vs CIN | 144 | L 4-5 | 82-62 | 2 | 30,867 | David Bush | Edinson Volquez | Jared Burton | Salomon Torres | Francisco Cordero | 676 | 608 | 68 |
| 2008-09-09 | vs CIN | 145 | L 4-5 | 82-63 | 2 | 30,312 | Jeff Suppan | Ramon Ramirez | Jon Adkins | Seth McClung | Francisco Cordero | 680 | 613 | 67 |
| 2008-09-10 | vs CIN | 146 | W 4-3 | 83-63 | 2 | 30,124 | CC Sabathia | Bronson Arroyo | Guillermo Mota | David Weathers | Salomon Torres | 684 | 616 | 68 |
| 2008-09-11 | @ PHI | 147 | L 3-6 | 83-64 | 2 | 39,994 | Ben Sheets | Jamie Moyer | Jamie Moyer | Ben Sheets | Brad Lidge | 687 | 622 | 65 |
| 2008-09-13 | @ PHI | 148 | L 3-7 | 83-65 | 2 | 45,105 | Manny Parra | Cole Hamels | Cole Hamels | Manny Parra | | 690 | 629 | 61 |
| 2008-09-14 | @ PHI | 149 | L 3-7 | 83-67 | 2 | 43,950 | David Bush | Joe Blanton | Scott Eyre | Guillermo Mota | | 693 | 636 | 57 |
| 2008-09-14 | @ PHI | 150 | L 1-6 | 83-67 | 2 | 39,776 | Jeff Suppan | Brett Myers | Brett Myers | Jeff Suppan | | 694 | 642 | 52 |
| 2008-09-16 | @ CHN | 151 | L 4-5 | 83-68 | 2 | 40,738 | CC Sabathia | Ryan Dempster | Ryan Dempster | CC Sabathia | Kerry Wood | 698 | 647 | 51 |
| 2008-09-17 | @ CHN | 152 | W 6-2 | 84-68 | 2 | 41,200 | Ben Sheets | Jason Marquis | Mark DiFelice | Jason Marquis | | 704 | 649 | 55 |
| 2008-09-18 | @ CHN | 153 | L 6-7 | 84-69 | 2 | 40,678 | David Bush | Rich Harden | Kerry Wood | Carlos Villanueva | | 710 | 656 | 54 |
| 2008-09-19 | @ CIN | 154 | L 2-11 | 84-70 | 2 | 20,855 | Jeff Suppan | Ramon Ramirez | Ramon Ramirez | Jeff Suppan | | 712 | 667 | 45 |
| 2008-09-20 | @ CIN | 155 | L 3-4 | 84-71 | 2 | 24,440 | CC Sabathia | Johnny Cueto | Johnny Cueto | CC Sabathia | Francisco Cordero | 715 | 671 | 44 |
| 2008-09-21 | @ CIN | 156 | W 8-1 | 85-71 | 2 | 22,624 | Seth McClung | Bronson Arroyo | Todd Coffey | Bronson Arroyo | | 723 | 672 | 51 |
| 2008-09-23 | vs PIT | 157 | W 7-5 | 86-71 | 2 | 36,612 | David Bush | Jeff Karstens | Salomon Torres | T.J. Beam | | 730 | 677 | 53 |
| 2008-09-24 | vs PIT | 158 | W 4-2 | 87-71 | 2 | 31,164 | CC Sabathia | Paul Maholm | CC Sabathia | Paul Maholm | Salomon Torres | 734 | 679 | 55 |
| 2008-09-25 | vs PIT | 159 | W 5-1 | 88-71 | 2 | 40,102 | Yovani Gallardo | Zach Duke | Mitch Stetter | Jesse Chavez | | 739 | 680 | 59 |
| 2008-09-26 | vs CHN | 160 | W 5-1 | 89-71 | 2 | 44,084 | Jeff Suppan | Ryan Dempster | Seth McClung | Sean Marshall | | 744 | 681 | 63 |
| 2008-09-27 | vs CHN | 161 | L 3-7 | 89-72 | 2 | 45,288 | Ben Sheets | Ted Lilly | Ted Lilly | Ben Sheets | | 747 | 688 | 59 |
| 2008-09-28 | vs CHN | 162 | W 3-1 | 90-72 | 2 | 45,299 | CC Sabathia | Angel Guzman | CC Sabathia | Bob Howry | | 750 | 689 | 61 |