| 2008-03-31 | vs SFN | 1 | W 5-0 | 1-0 | 2 | 56,000 | Brad Penny | Barry Zito | Brad Penny | Barry Zito | | 5 | 0 | 5 |
| 2008-04-01 | vs SFN | 2 | W 3-2 | 2-0 | 3 | 44,054 | Derek Lowe | Matt Cain | Takashi Saito | Keiichi Yabu | | 8 | 2 | 6 |
| 2008-04-02 | vs SFN | 3 | L 1-2 | 2-1 | 1 | 43,217 | Hong-Chih Kuo | Merkin Valdez | Tim Lincecum | Esteban Loaiza | Brian Wilson | 9 | 4 | 5 |
| 2008-04-04 | @ SDN | 4 | W 7-1 | 3-1 | 1 | 42,474 | Hiroki Kuroda | Justin Germano | Hiroki Kuroda | Joe Thatcher | | 16 | 5 | 11 |
| 2008-04-05 | @ SDN | 5 | L 1-4 | 3-2 | 3 | 38,819 | Brad Penny | Jake Peavy | Jake Peavy | Brad Penny | | 17 | 9 | 8 |
| 2008-04-06 | @ SDN | 6 | W 3-2 | 4-2 | 2 | 44,165 | Derek Lowe | Chris Young | Jonathan Broxton | Trevor Hoffman | Takashi Saito | 20 | 11 | 9 |
| 2008-04-07 | @ ARI | 7 | L 3-9 | 4-3 | 3 | 49,057 | Esteban Loaiza | Dan Haren | Dan Haren | Esteban Loaiza | | 23 | 20 | 3 |
| 2008-04-08 | @ ARI | 8 | L 5-10 | 4-4 | 3 | 28,973 | Chad Billingsley | Doug Davis | Doug Davis | Chad Billingsley | | 28 | 30 | -2 |
| 2008-04-09 | @ ARI | 9 | L 3-4 | 4-5 | 4 | 23,331 | Hiroki Kuroda | Micah Owings | Micah Owings | Hiroki Kuroda | Brandon Lyon | 31 | 34 | -3 |
| 2008-04-11 | vs SDN | 10 | L 5-7 | 4-6 | 4 | 54,052 | Brad Penny | Jake Peavy | Jake Peavy | Brad Penny | Trevor Hoffman | 36 | 41 | -5 |
| 2008-04-12 | vs SDN | 11 | W 11-1 | 5-6 | 3 | 54,955 | Derek Lowe | Chris Young | Derek Lowe | Chris Young | | 47 | 42 | 5 |
| 2008-04-13 | vs SDN | 12 | L 0-1 | 5-7 | 4 | 47,357 | Chad Billingsley | Greg Maddux | Greg Maddux | Chad Billingsley | Trevor Hoffman | 47 | 43 | 4 |
| 2008-04-14 | vs PIT | 13 | L 4-6 | 5-8 | 5 | 37,334 | Hiroki Kuroda | Zach Duke | Tyler Yates | Takashi Saito | Matt Capps | 51 | 49 | 2 |
| 2008-04-15 | vs PIT | 14 | W 11-2 | 6-8 | 3 | 37,896 | Hong-Chih Kuo | Matt Morris | Esteban Loaiza | Matt Morris | | 62 | 51 | 11 |
| 2008-04-16 | vs PIT | 15 | W 8-1 | 7-8 | 3 | 53,629 | Brad Penny | Paul Maholm | Brad Penny | Paul Maholm | | 70 | 52 | 18 |
| 2008-04-18 | @ ATL | 16 | L 1-6 | 7-9 | 4 | 38,250 | Derek Lowe | Jeff Bennett | Will Ohman | Derek Lowe | | 71 | 58 | 13 |
| 2008-04-19 | @ ATL | 17 | L 1-4 | 7-10 | 4 | 40,451 | Chad Billingsley | Chuck James | Chuck James | Chad Billingsley | Manny Acosta | 72 | 62 | 10 |
| 2008-04-20 | @ ATL | 18 | L 1-6 | 7-11 | 5 | 36,772 | Hiroki Kuroda | Jair Jurrjens | Jair Jurrjens | Hiroki Kuroda | | 73 | 68 | 5 |
| 2008-04-21 | @ CIN | 19 | W 9-3 | 8-11 | 4 | 14,446 | Brad Penny | Matt Belisle | Brad Penny | Matt Belisle | Chan Ho Park | 82 | 71 | 11 |
| 2008-04-22 | @ CIN | 20 | L 1-8 | 8-12 | 4 | 14,763 | Hong-Chih Kuo | Edinson Volquez | Edinson Volquez | Hong-Chih Kuo | | 83 | 79 | 4 |
| 2008-04-23 | vs ARI | 21 | W 8-3 | 9-12 | 3 | 42,590 | Derek Lowe | Dan Haren | Derek Lowe | Dan Haren | Takashi Saito | 91 | 82 | 9 |
| 2008-04-24 | vs ARI | 22 | L 4-6 | 9-13 | 4 | 38,350 | Chad Billingsley | Edgar Gonzalez | Edgar Gonzalez | Chad Billingsley | Brandon Lyon | 95 | 88 | 7 |
| 2008-04-25 | vs COL | 23 | W 8-7 | 10-13 | 4 | 53,205 | Hiroki Kuroda | Ubaldo Jimenez | Chan Ho Park | Taylor Buchholz | | 103 | 95 | 8 |
| 2008-04-26 | vs COL | 24 | W 11-3 | 11-13 | 2 | 50,469 | Brad Penny | Mark Redman | Brad Penny | Mark Redman | | 114 | 98 | 16 |
| 2008-04-27 | vs COL | 25 | W 3-2 | 12-13 | 2 | 50,670 | Esteban Loaiza | Jeff Francis | Joe Beimel | Manuel Corpas | | 117 | 100 | 17 |
| 2008-04-29 | @ FLO | 26 | W 7-6 | 13-13 | 2 | 11,334 | Derek Lowe | Andrew Miller | Joe Beimel | Kevin Gregg | Takashi Saito | 124 | 106 | 18 |
| 2008-04-30 | @ FLO | 27 | W 13-1 | 14-13 | 2 | 10,792 | Chad Billingsley | Scott Olsen | Chad Billingsley | Scott Olsen | | 137 | 107 | 30 |
| 2008-05-01 | @ FLO | 28 | W 5-3 | 15-13 | 2 | 15,556 | Hiroki Kuroda | Burke Badenhop | Joe Beimel | Kevin Gregg | Takashi Saito | 142 | 110 | 32 |
| 2008-05-02 | @ COL | 29 | W 11-6 | 16-13 | 2 | 30,291 | Brad Penny | Jeff Francis | Brad Penny | Jeff Francis | | 153 | 116 | 37 |
| 2008-05-03 | @ COL | 30 | W 12-7 | 17-13 | 2 | 38,597 | Esteban Loaiza | Jorge de la Rosa | Hong-Chih Kuo | Jorge de la Rosa | | 165 | 123 | 42 |
| 2008-05-04 | @ COL | 31 | L 2-7 | 17-14 | 2 | 43,726 | Derek Lowe | Aaron Cook | Aaron Cook | Derek Lowe | Taylor Buchholz | 167 | 130 | 37 |
| 2008-05-05 | vs NYN | 32 | W 5-1 | 18-14 | 2 | 44,181 | Chad Billingsley | Oliver Perez | Chad Billingsley | Oliver Perez | | 172 | 131 | 41 |
| 2008-05-06 | vs NYN | 33 | W 5-4 | 19-14 | 2 | 43,927 | Hiroki Kuroda | Nelson Figueroa | Hong-Chih Kuo | Nelson Figueroa | Takashi Saito | 177 | 135 | 42 |
| 2008-05-07 | vs NYN | 34 | L 1-12 | 19-15 | 2 | 40,696 | Brad Penny | John Maine | John Maine | Brad Penny | | 178 | 147 | 31 |
| 2008-05-09 | vs HOU | 35 | L 1-7 | 19-16 | 2 | 52,658 | Derek Lowe | Brian Moehler | Brian Moehler | Derek Lowe | | 179 | 154 | 25 |
| 2008-05-10 | vs HOU | 36 | L 0-5 | 19-17 | 2 | 45,212 | Chad Billingsley | Chris Sampson | Chris Sampson | Chad Billingsley | | 179 | 159 | 20 |
| 2008-05-11 | vs HOU | 37 | L 5-8 | 19-18 | 2 | 40,217 | Hiroki Kuroda | Shawn Chacon | Geoff Geary | Jonathan Broxton | Jose Valverde | 184 | 167 | 17 |
| 2008-05-13 | @ MIL | 38 | L 3-5 | 19-19 | 2 | 26,465 | Brad Penny | Carlos Villanueva | Carlos Villanueva | Brad Penny | Eric Gagne | 187 | 172 | 15 |
| 2008-05-14 | @ MIL | 39 | W 6-4 | 20-19 | 2 | 27,562 | Derek Lowe | Manny Parra | Jonathan Broxton | Guillermo Mota | Takashi Saito | 193 | 176 | 17 |
| 2008-05-15 | @ MIL | 40 | W 7-2 | 21-19 | 2 | 30,444 | Chad Billingsley | Ben Sheets | Chad Billingsley | Ben Sheets | | 200 | 178 | 22 |
| 2008-05-16 | @ ANA | 41 | L 2-4 | 21-20 | 2 | 44,047 | Hiroki Kuroda | Joe Saunders | Joe Saunders | Hiroki Kuroda | Francisco Rodriguez | 202 | 182 | 20 |
| 2008-05-17 | @ ANA | 42 | W 6-3 | 22-20 | 2 | 43,906 | Chan Ho Park | Ervin Santana | Hong-Chih Kuo | Ervin Santana | | 208 | 185 | 23 |
| 2008-05-18 | @ ANA | 43 | L 2-10 | 22-21 | 2 | 44,007 | Derek Lowe | Jered Weaver | Jered Weaver | Derek Lowe | | 210 | 195 | 15 |
| 2008-05-19 | vs CIN | 44 | W 6-5 | 23-21 | 2 | 34,669 | Brad Penny | Bronson Arroyo | Takashi Saito | David Weathers | | 216 | 200 | 16 |
| 2008-05-20 | vs CIN | 45 | W 4-1 | 24-21 | 2 | 34,306 | Chad Billingsley | Matt Belisle | Chad Billingsley | Matt Belisle | Takashi Saito | 220 | 201 | 19 |
| 2008-05-21 | vs CIN | 46 | W 5-2 | 25-21 | 2 | 33,224 | Hiroki Kuroda | Johnny Cueto | Hiroki Kuroda | Johnny Cueto | Takashi Saito | 225 | 203 | 22 |
| 2008-05-23 | vs SLN | 47 | L 1-2 | 25-22 | 2 | 52,281 | Derek Lowe | Adam Wainwright | Adam Wainwright | Derek Lowe | Ryan Franklin | 226 | 205 | 21 |
| 2008-05-24 | vs SLN | 48 | L 0-4 | 25-23 | 2 | 44,785 | Brad Penny | Kyle Lohse | Kyle Lohse | Brad Penny | | 226 | 209 | 17 |
| 2008-05-25 | vs SLN | 49 | W 4-3 | 26-23 | 2 | 46,566 | Clayton Kershaw | Todd Wellemeyer | Takashi Saito | Mike Parisi | | 230 | 212 | 18 |
| 2008-05-26 | @ CHN | 50 | L 1-3 | 26-24 | 2 | 41,583 | Chad Billingsley | Ryan Dempster | Ryan Dempster | Chad Billingsley | Kerry Wood | 231 | 215 | 16 |
| 2008-05-27 | @ CHN | 51 | L 1-3 | 26-25 | 2 | 39,894 | Hiroki Kuroda | Sean Gallagher | Sean Gallagher | Hiroki Kuroda | Kerry Wood | 232 | 218 | 14 |
| 2008-05-28 | @ CHN | 52 | L 1-2 | 26-26 | 2 | 39,945 | Derek Lowe | Carlos Zambrano | Bob Howry | Chan Ho Park | | 233 | 220 | 13 |
| 2008-05-29 | @ NYN | 53 | L 4-8 | 26-27 | 2 | 52,886 | Brad Penny | Claudio Vargas | Claudio Vargas | Brad Penny | | 237 | 228 | 9 |
| 2008-05-30 | @ NYN | 54 | W 9-5 | 27-27 | 2 | 52,176 | Clayton Kershaw | John Maine | Chan Ho Park | Aaron Heilman | | 246 | 233 | 13 |
| 2008-05-31 | @ NYN | 55 | L 2-3 | 27-28 | 2 | 53,528 | Chad Billingsley | Mike Pelfrey | Duaner Sanchez | Jonathan Broxton | Billy Wagner | 248 | 236 | 12 |
| 2008-06-01 | @ NYN | 56 | L 1-6 | 27-29 | 2 | 50,263 | Hiroki Kuroda | Johan Santana | Johan Santana | Hiroki Kuroda | | 249 | 242 | 7 |
| 2008-06-02 | vs COL | 57 | W 8-2 | 28-29 | 2 | 39,098 | Derek Lowe | Greg Reynolds | Derek Lowe | Greg Reynolds | | 257 | 244 | 13 |
| 2008-06-03 | vs COL | 58 | L 0-3 | 28-30 | 2 | 38,548 | Brad Penny | Jeff Francis | Jeff Francis | Brad Penny | Brian Fuentes | 257 | 247 | 10 |
| 2008-06-04 | vs COL | 59 | L 1-2 | 28-31 | 2 | 36,393 | Clayton Kershaw | Aaron Cook | Aaron Cook | Clayton Kershaw | Brian Fuentes | 258 | 249 | 9 |
| 2008-06-05 | vs CHN | 60 | L 4-5 | 28-32 | 2 | 44,988 | Chad Billingsley | Ryan Dempster | Bob Howry | Takashi Saito | Kerry Wood | 262 | 254 | 8 |
| 2008-06-06 | vs CHN | 61 | W 3-0 | 29-32 | 2 | 52,484 | Hiroki Kuroda | Sean Gallagher | Hiroki Kuroda | Sean Gallagher | | 265 | 254 | 11 |
| 2008-06-07 | vs CHN | 62 | W 7-3 | 30-32 | 2 | 50,020 | Derek Lowe | Carlos Zambrano | Derek Lowe | Carlos Zambrano | | 272 | 257 | 15 |
| 2008-06-08 | vs CHN | 63 | L 1-3 | 30-33 | 2 | 49,994 | Brad Penny | Jason Marquis | Jason Marquis | Brad Penny | Kerry Wood | 273 | 260 | 13 |
| 2008-06-10 | @ SDN | 64 | W 7-2 | 31-33 | 2 | 26,860 | Clayton Kershaw | Greg Maddux | Scott Proctor | Justin Hampson | | 280 | 262 | 18 |
| 2008-06-11 | @ SDN | 65 | L 1-4 | 31-34 | 2 | 29,218 | Chad Billingsley | Randy Wolf | Randy Wolf | Chad Billingsley | Trevor Hoffman | 281 | 266 | 15 |
| 2008-06-12 | @ SDN | 66 | L 0-9 | 31-35 | 2 | 39,354 | Hiroki Kuroda | Jake Peavy | Jake Peavy | Hiroki Kuroda | | 281 | 275 | 6 |
| 2008-06-13 | @ DET | 67 | L 0-5 | 31-36 | 2 | 40,430 | Derek Lowe | Armando Galarraga | Armando Galarraga | Derek Lowe | Freddy Dolsi | 281 | 280 | 1 |
| 2008-06-14 | @ DET | 68 | L 7-12 | 31-37 | 2 | 42,348 | Brad Penny | Eddie Bonine | Eddie Bonine | Brad Penny | | 288 | 292 | -4 |
| 2008-06-15 | @ DET | 69 | L 4-5 | 31-38 | 2 | 41,189 | Clayton Kershaw | Nate Robertson | Nate Robertson | Chan Ho Park | Todd Jones | 292 | 297 | -5 |
| 2008-06-17 | @ CIN | 70 | W 3-1 | 32-38 | 2 | 26,906 | Chad Billingsley | Johnny Cueto | Chad Billingsley | Johnny Cueto | Takashi Saito | 295 | 298 | -3 |
| 2008-06-18 | @ CIN | 71 | W 6-1 | 33-38 | 2 | 20,055 | Derek Lowe | Bronson Arroyo | Derek Lowe | Bronson Arroyo | | 301 | 299 | 2 |
| 2008-06-19 | @ CIN | 72 | W 7-4 | 34-38 | 2 | 30,136 | Eric Stults | Aaron Harang | Eric Stults | Aaron Harang | Takashi Saito | 308 | 303 | 5 |
| 2008-06-20 | vs CLE | 73 | L 4-6 | 34-39 | 2 | 50,667 | Clayton Kershaw | Cliff Lee | Joe Borowski | Takashi Saito | Masahide Kobayashi | 312 | 309 | 3 |
| 2008-06-21 | vs CLE | 74 | L 2-7 | 34-40 | 2 | 45,036 | Chan Ho Park | CC Sabathia | Masahide Kobayashi | Cory Wade | | 314 | 316 | -2 |
| 2008-06-22 | vs CLE | 75 | W 4-3 | 35-40 | 2 | 39,993 | Chad Billingsley | Paul Byrd | Chad Billingsley | Paul Byrd | Takashi Saito | 318 | 319 | -1 |
| 2008-06-24 | vs CHA | 76 | L 1-6 | 35-41 | 2 | 43,900 | Derek Lowe | Mark Buehrle | Mark Buehrle | Derek Lowe | | 319 | 325 | -6 |
| 2008-06-25 | vs CHA | 77 | W 5-0 | 36-41 | 2 | 40,162 | Eric Stults | Gavin Floyd | Eric Stults | Gavin Floyd | | 324 | 325 | -1 |
| 2008-06-26 | vs CHA | 78 | L 0-2 | 36-42 | 2 | 37,956 | Clayton Kershaw | John Danks | John Danks | Clayton Kershaw | Bobby Jenks | 324 | 327 | -3 |
| 2008-06-27 | vs ANA | 79 | W 6-0 | 37-42 | 2 | 50,419 | Chan Ho Park | Joe Saunders | Chan Ho Park | Joe Saunders | | 330 | 327 | 3 |
| 2008-06-28 | vs ANA | 80 | W 1-0 | 38-42 | 2 | 55,784 | Chad Billingsley | Jered Weaver | Chad Billingsley | Jered Weaver | Takashi Saito | 331 | 327 | 4 |
| 2008-06-29 | vs ANA | 81 | L 0-1 | 38-43 | 2 | 48,155 | Derek Lowe | John Lackey | John Lackey | Derek Lowe | Francisco Rodriguez | 331 | 328 | 3 |
| 2008-06-30 | @ HOU | 82 | L 1-4 | 38-44 | 2 | 28,827 | Eric Stults | Roy Oswalt | Roy Oswalt | Eric Stults | Jose Valverde | 332 | 332 | 0 |
| 2008-07-01 | @ HOU | 83 | W 7-6 | 39-44 | 2 | 31,914 | Clayton Kershaw | Wandy Rodriguez | Chan Ho Park | Wesley Wright | Takashi Saito | 339 | 338 | 1 |
| 2008-07-02 | @ HOU | 84 | W 4-1 | 40-44 | 2 | 34,058 | Hiroki Kuroda | Runelvys Hernandez | Hiroki Kuroda | Runelvys Hernandez | | 343 | 339 | 4 |
| 2008-07-03 | @ HOU | 85 | W 5-2 | 41-44 | 2 | 35,696 | Chad Billingsley | Brandon Backe | Chad Billingsley | Brandon Backe | Takashi Saito | 348 | 341 | 7 |
| 2008-07-04 | @ SFN | 86 | W 10-7 | 42-44 | 2 | 40,447 | Derek Lowe | Jonathan Sanchez | Derek Lowe | Osiris Matos | Takashi Saito | 358 | 348 | 10 |
| 2008-07-05 | @ SFN | 87 | L 2-5 | 42-45 | 2 | 40,741 | Chan Ho Park | Barry Zito | Barry Zito | Brian Falkenborg | Brian Wilson | 360 | 353 | 7 |
| 2008-07-06 | @ SFN | 88 | W 5-3 | 43-45 | 2 | 38,290 | Eric Stults | Matt Cain | Brian Falkenborg | Matt Cain | Takashi Saito | 365 | 356 | 9 |
| 2008-07-07 | vs ATL | 89 | W 3-0 | 44-45 | 2 | 39,896 | Hiroki Kuroda | Jorge Campillo | Hiroki Kuroda | Jorge Campillo | | 368 | 356 | 12 |
| 2008-07-08 | vs ATL | 90 | L 3-9 | 44-46 | 2 | 39,702 | Chad Billingsley | Jair Jurrjens | Jair Jurrjens | Chad Billingsley | | 371 | 365 | 6 |
| 2008-07-09 | vs ATL | 91 | W 2-1 | 45-46 | 2 | 39,815 | Derek Lowe | Tim Hudson | Derek Lowe | Tim Hudson | Takashi Saito | 373 | 366 | 7 |
| 2008-07-10 | vs FLO | 92 | L 4-5 | 45-47 | 2 | 40,417 | Chan Ho Park | Josh Johnson | Joe Nelson | Brian Falkenborg | Kevin Gregg | 377 | 371 | 6 |
| 2008-07-11 | vs FLO | 93 | L 1-3 | 45-48 | 2 | 49,545 | Eric Stults | Chris Volstad | Chris Volstad | Eric Stults | Kevin Gregg | 378 | 374 | 4 |
| 2008-07-12 | vs FLO | 94 | L 3-5 | 45-49 | 2 | 55,220 | Hiroki Kuroda | Ricky Nolasco | Doug Waechter | Ramon Troncoso | Kevin Gregg | 381 | 379 | 2 |
| 2008-07-13 | vs FLO | 95 | W 9-1 | 46-49 | 2 | 42,213 | Chad Billingsley | Andrew Miller | Chad Billingsley | Andrew Miller | | 390 | 380 | 10 |
| 2008-07-18 | @ ARI | 96 | W 8-7 | 47-49 | 2 | 38,561 | Hiroki Kuroda | Doug Davis | Cory Wade | Doug Slaten | Jonathan Broxton | 398 | 387 | 11 |
| 2008-07-19 | @ ARI | 97 | L 2-3 | 47-50 | 2 | 41,458 | Chad Billingsley | Dan Haren | Dan Haren | Chad Billingsley | Brandon Lyon | 400 | 390 | 10 |
| 2008-07-20 | @ ARI | 98 | W 6-5 | 48-50 | 2 | 39,217 | Derek Lowe | Brandon Webb | Ramon Troncoso | Brandon Lyon | Jonathan Broxton | 406 | 395 | 11 |
| 2008-07-21 | @ COL | 99 | W 16-10 | 49-50 | 2 | 38,291 | Eric Stults | Kip Wells | Brian Falkenborg | Kip Wells | | 422 | 405 | 17 |
| 2008-07-22 | @ COL | 100 | L 1-10 | 49-51 | 2 | 41,567 | Clayton Kershaw | Ubaldo Jimenez | Ubaldo Jimenez | Clayton Kershaw | | 423 | 415 | 8 |
| 2008-07-23 | @ COL | 101 | L 3-5 | 49-52 | 2 | 36,305 | Hiroki Kuroda | Glendon Rusch | Glendon Rusch | Hiroki Kuroda | Brian Fuentes | 426 | 420 | 6 |
| 2008-07-25 | vs WAS | 102 | W 3-2 | 50-52 | 2 | 47,313 | Chad Billingsley | John Lannan | Chad Billingsley | John Lannan | Jonathan Broxton | 429 | 422 | 7 |
| 2008-07-26 | vs WAS | 103 | W 6-0 | 51-52 | 2 | 42,122 | Derek Lowe | Odalis Perez | Derek Lowe | Odalis Perez | | 435 | 422 | 13 |
| 2008-07-27 | vs WAS | 104 | W 2-0 | 52-52 | 2 | 38,660 | Clayton Kershaw | Jason Bergmann | Clayton Kershaw | Jason Bergmann | Jonathan Broxton | 437 | 422 | 15 |
| 2008-07-28 | vs SFN | 105 | L 6-7 | 52-53 | 2 | 37,483 | Hiroki Kuroda | Kevin Correia | Kevin Correia | Hiroki Kuroda | Brian Wilson | 443 | 429 | 14 |
| 2008-07-29 | vs SFN | 106 | W 2-0 | 53-53 | 2 | 40,110 | Jason Johnson | Matt Cain | Jason Johnson | Matt Cain | Jonathan Broxton | 445 | 429 | 16 |
| 2008-07-30 | vs SFN | 107 | W 4-0 | 54-53 | 2 | 41,282 | Chad Billingsley | Jonathan Sanchez | Chad Billingsley | Jonathan Sanchez | | 449 | 429 | 20 |
| 2008-07-31 | vs ARI | 108 | L 1-2 | 54-54 | 2 | 42,440 | Derek Lowe | Brandon Webb | Brandon Webb | Derek Lowe | Brandon Lyon | 450 | 431 | 19 |
| 2008-08-01 | vs ARI | 109 | L 1-2 | 54-55 | 2 | 55,239 | Clayton Kershaw | Randy Johnson | Randy Johnson | Chan Ho Park | Brandon Lyon | 451 | 433 | 18 |
| 2008-08-02 | vs ARI | 110 | W 4-2 | 55-55 | 2 | 54,544 | Hiroki Kuroda | Yusmeiro Petit | Hiroki Kuroda | Yusmeiro Petit | Chan Ho Park | 455 | 435 | 20 |
| 2008-08-03 | vs ARI | 111 | W 9-3 | 56-55 | 2 | 52,972 | Jason Johnson | Doug Davis | Cory Wade | Doug Davis | | 464 | 438 | 26 |
| 2008-08-05 | @ SLN | 112 | L 4-6 | 56-56 | 2 | 40,773 | Chad Billingsley | Chris Carpenter | Jaime Garcia | Jason Johnson | | 468 | 444 | 24 |
| 2008-08-06 | @ SLN | 113 | L 6-9 | 56-57 | 2 | 42,581 | Derek Lowe | Joel Pineiro | Joel Pineiro | Derek Lowe | Chris Perez | 474 | 453 | 21 |
| 2008-08-07 | @ SLN | 114 | W 4-1 | 57-57 | 2 | 40,500 | Clayton Kershaw | Kyle Lohse | Clayton Kershaw | Kyle Lohse | Jonathan Broxton | 478 | 454 | 24 |
| 2008-08-08 | @ SFN | 115 | W 6-2 | 58-57 | 2 | 40,142 | Brad Penny | Barry Zito | Brad Penny | Barry Zito | Jonathan Broxton | 484 | 456 | 28 |
| 2008-08-09 | @ SFN | 116 | L 2-3 | 58-58 | 2 | 41,963 | Hiroki Kuroda | Kevin Correia | Tyler Walker | Jonathan Broxton | | 486 | 459 | 27 |
| 2008-08-10 | @ SFN | 117 | L 4-5 | 58-59 | 2 | 41,804 | Chad Billingsley | Matt Cain | Jack Taschner | Hong-Chih Kuo | | 490 | 464 | 26 |
| 2008-08-11 | vs PHI | 118 | W 8-6 | 59-59 | 2 | 45,547 | Derek Lowe | Kyle Kendrick | Derek Lowe | Kyle Kendrick | Jonathan Broxton | 498 | 470 | 28 |
| 2008-08-12 | vs PHI | 119 | W 4-3 | 60-59 | 2 | 47,586 | Clayton Kershaw | Cole Hamels | Hong-Chih Kuo | J.C. Romero | | 502 | 473 | 29 |
| 2008-08-13 | vs PHI | 120 | W 7-6 | 61-59 | 2 | 45,786 | Brad Penny | Joe Blanton | Jonathan Broxton | Clay Condrey | | 509 | 479 | 30 |
| 2008-08-14 | vs PHI | 121 | W 3-1 | 62-59 | 2 | 51,060 | Hiroki Kuroda | Brett Myers | Hiroki Kuroda | Brett Myers | Hong-Chih Kuo | 512 | 480 | 32 |
| 2008-08-15 | vs MIL | 122 | W 5-3 | 63-59 | 2 | 44,547 | Chad Billingsley | Manny Parra | Chad Billingsley | Manny Parra | Jonathan Broxton | 517 | 483 | 34 |
| 2008-08-16 | vs MIL | 123 | L 3-4 | 63-60 | 2 | 52,889 | Derek Lowe | David Bush | Salomon Torres | Jonathan Broxton | David Riske | 520 | 487 | 33 |
| 2008-08-17 | vs MIL | 124 | W 7-5 | 64-60 | 2 | 45,267 | Clayton Kershaw | Jeff Suppan | Joe Beimel | Carlos Villanueva | | 527 | 492 | 35 |
| 2008-08-19 | vs COL | 125 | L 3-8 | 64-61 | 2 | 46,687 | Hiroki Kuroda | Ubaldo Jimenez | Ubaldo Jimenez | Hiroki Kuroda | | 530 | 500 | 30 |
| 2008-08-20 | vs COL | 126 | L 3-4 | 64-62 | 2 | 48,183 | Chad Billingsley | Jeff Francis | Taylor Buchholz | Jonathan Broxton | Brian Fuentes | 533 | 504 | 29 |
| 2008-08-21 | vs COL | 127 | W 3-1 | 65-62 | 2 | 44,885 | Derek Lowe | Jorge de la Rosa | Derek Lowe | Jorge de la Rosa | Jonathan Broxton | 536 | 505 | 31 |
| 2008-08-22 | @ PHI | 128 | L 1-8 | 65-63 | 2 | 42,620 | Greg Maddux | Kyle Kendrick | Kyle Kendrick | Greg Maddux | | 537 | 513 | 24 |
| 2008-08-23 | @ PHI | 129 | L 2-9 | 65-64 | 2 | 45,019 | Clayton Kershaw | Cole Hamels | Cole Hamels | Clayton Kershaw | | 539 | 522 | 17 |
| 2008-08-24 | @ PHI | 130 | L 2-5 | 65-65 | 2 | 43,039 | Hiroki Kuroda | Joe Blanton | Chad Durbin | Joe Beimel | | 541 | 527 | 14 |
| 2008-08-25 | @ PHI | 131 | L 0-5 | 65-66 | 2 | 40,873 | Chad Billingsley | Brett Myers | Brett Myers | Chad Billingsley | | 541 | 532 | 9 |
| 2008-08-26 | @ WAS | 132 | L 1-2 | 65-67 | 2 | 26,110 | Derek Lowe | Collin Balester | Collin Balester | Derek Lowe | Joel Hanrahan | 542 | 534 | 8 |
| 2008-08-27 | @ WAS | 133 | L 4-5 | 65-68 | 2 | 22,907 | Greg Maddux | Tim Redding | Tim Redding | Greg Maddux | Joel Hanrahan | 546 | 539 | 7 |
| 2008-08-28 | @ WAS | 134 | L 2-11 | 65-69 | 2 | 26,338 | Clayton Kershaw | John Lannan | John Lannan | Clayton Kershaw | | 548 | 550 | -2 |
| 2008-08-29 | @ ARI | 135 | L 3-9 | 65-70 | 2 | 32,610 | Hiroki Kuroda | Doug Davis | Doug Davis | Hiroki Kuroda | | 551 | 559 | -8 |
| 2008-08-30 | @ ARI | 136 | W 6-2 | 66-70 | 2 | 49,045 | Chad Billingsley | Dan Haren | Chad Billingsley | Dan Haren | | 557 | 561 | -4 |
| 2008-08-31 | @ ARI | 137 | W 8-1 | 67-70 | 2 | 43,456 | Derek Lowe | Brandon Webb | Derek Lowe | Brandon Webb | | 565 | 562 | 3 |
| 2008-09-01 | vs SDN | 138 | W 5-2 | 68-70 | 2 | 44,087 | Greg Maddux | Chris Young | Greg Maddux | Chris Young | Jonathan Broxton | 570 | 564 | 6 |
| 2008-09-02 | vs SDN | 139 | W 8-4 | 69-70 | 2 | 39,330 | Clayton Kershaw | Cha-Seung Baek | Clayton Kershaw | Cha-Seung Baek | | 578 | 568 | 10 |
| 2008-09-03 | vs SDN | 140 | W 6-4 | 70-70 | 2 | 48,822 | Hiroki Kuroda | Wade LeBlanc | Hiroki Kuroda | Wade LeBlanc | Jonathan Broxton | 584 | 572 | 12 |
| 2008-09-05 | vs ARI | 141 | W 7-0 | 71-70 | 2 | 52,270 | Derek Lowe | Dan Haren | Derek Lowe | Dan Haren | | 591 | 572 | 19 |
| 2008-09-06 | vs ARI | 142 | W 7-2 | 72-70 | 1 | 47,543 | Chad Billingsley | Brandon Webb | Chad Billingsley | Brandon Webb | | 598 | 574 | 24 |
| 2008-09-07 | vs ARI | 143 | W 5-3 | 73-70 | 1 | 54,137 | Clayton Kershaw | Max Scherzer | Hong-Chih Kuo | Jon Rauch | Jonathan Broxton | 603 | 577 | 26 |
| 2008-09-08 | @ SDN | 144 | L 0-4 | 73-71 | 1 | 25,942 | Greg Maddux | Cha-Seung Baek | Cha-Seung Baek | Greg Maddux | | 603 | 581 | 22 |
| 2008-09-09 | @ SDN | 145 | W 6-2 | 74-71 | 1 | 26,614 | Hiroki Kuroda | Wade LeBlanc | Joe Beimel | Heath Bell | | 609 | 583 | 26 |
| 2008-09-10 | @ SDN | 146 | W 7-2 | 75-71 | 1 | 27,208 | Derek Lowe | Shawn Estes | Derek Lowe | Shawn Estes | | 616 | 585 | 31 |
| 2008-09-12 | @ COL | 147 | W 7-2 | 76-71 | 1 | 30,147 | Chad Billingsley | Jeff Francis | Chad Billingsley | Jeff Francis | | 623 | 587 | 36 |
| 2008-09-13 | @ COL | 148 | W 5-1 | 77-71 | 1 | 40,291 | Clayton Kershaw | Jorge de la Rosa | Clayton Kershaw | Jorge de la Rosa | | 628 | 588 | 40 |
| 2008-09-14 | @ COL | 149 | L 0-1 | 77-72 | 1 | 28,910 | Greg Maddux | Aaron Cook | Manuel Corpas | Hong-Chih Kuo | | 628 | 589 | 39 |
| 2008-09-15 | @ PIT | 150 | W 8-2 | 78-72 | 1 | 13,147 | Hiroki Kuroda | Ross Ohlendorf | Hiroki Kuroda | Ross Ohlendorf | | 636 | 591 | 45 |
| 2008-09-16 | @ PIT | 151 | W 6-2 | 79-72 | 1 | 12,741 | Derek Lowe | Jeff Karstens | Derek Lowe | Jeff Karstens | | 642 | 593 | 49 |
| 2008-09-17 | @ PIT | 152 | L 8-15 | 79-73 | 1 | 11,883 | Chad Billingsley | Zach Duke | John Grabow | Scott Elbert | | 650 | 608 | 42 |
| 2008-09-18 | @ PIT | 153 | W 4-3 | 80-73 | 1 | 12,709 | Clayton Kershaw | Paul Maholm | Scott Proctor | Craig Hansen | Jonathan Broxton | 654 | 611 | 43 |
| 2008-09-19 | vs SFN | 154 | L 1-7 | 80-74 | 1 | 55,589 | Greg Maddux | Barry Zito | Barry Zito | Greg Maddux | | 655 | 618 | 37 |
| 2008-09-20 | vs SFN | 155 | W 10-7 | 81-74 | 1 | 55,724 | Hiroki Kuroda | Brad Hennessey | Takashi Saito | Tyler Walker | | 665 | 625 | 40 |
| 2008-09-21 | vs SFN | 156 | L 0-1 | 81-75 | 1 | 55,294 | Derek Lowe | Matt Cain | Sergio Romo | Takashi Saito | Brian Wilson | 665 | 626 | 39 |
| 2008-09-23 | vs SDN | 157 | W 10-1 | 82-75 | 1 | 48,905 | Chad Billingsley | Wade LeBlanc | Chad Billingsley | Wade LeBlanc | | 675 | 627 | 48 |
| 2008-09-24 | vs SDN | 158 | W 12-4 | 83-75 | 1 | 44,776 | Clayton Kershaw | Shawn Estes | Clayton Kershaw | Mike Ekstrom | | 687 | 631 | 56 |
| 2008-09-25 | vs SDN | 159 | L 5-7 | 83-76 | 1 | 52,569 | Eric Stults | Jake Peavy | Jake Peavy | Eric Stults | Trevor Hoffman | 692 | 638 | 54 |
| 2008-09-26 | @ SFN | 160 | L 5-6 | 83-77 | 1 | 33,920 | Derek Lowe | Brad Hennessey | Tyler Walker | Jason Johnson | | 697 | 644 | 53 |
| 2008-09-27 | @ SFN | 161 | W 2-1 | 84-77 | 1 | 38,673 | Greg Maddux | Matt Cain | Greg Maddux | Matt Cain | Takashi Saito | 699 | 645 | 54 |
| 2008-09-28 | @ SFN | 162 | L 1-3 | 84-78 | 1 | 39,167 | Hiroki Kuroda | Tim Lincecum | Tim Lincecum | Chan Ho Park | Brian Wilson | 700 | 648 | 52 |