| 2008-03-31 | vs KCA | 1 | L 4-5 | 0-1 | 5 | 44,934 | Justin Verlander | Gil Meche | Leo Nunez | Denny Bautista | Joakim Soria | 4 | 5 | -1 |
| 2008-04-02 | vs KCA | 2 | L 0-4 | 0-2 | 5 | 32,348 | Kenny Rogers | Brian Bannister | Brian Bannister | Kenny Rogers | | 4 | 9 | -5 |
| 2008-04-03 | vs KCA | 3 | L 1-4 | 0-3 | 5 | 32,735 | Jeremy Bonderman | Zack Greinke | Zack Greinke | Jeremy Bonderman | Joakim Soria | 5 | 13 | -8 |
| 2008-04-04 | vs CHA | 4 | L 5-8 | 0-4 | 5 | 34,569 | Nate Robertson | Jose Contreras | Boone Logan | Jason Grilli | Bobby Jenks | 10 | 21 | -11 |
| 2008-04-05 | vs CHA | 5 | L 3-5 | 0-5 | 5 | 42,381 | Dontrelle Willis | Gavin Floyd | Gavin Floyd | Zach Miner | Bobby Jenks | 13 | 26 | -13 |
| 2008-04-06 | vs CHA | 6 | L 2-13 | 0-6 | 5 | 35,230 | Justin Verlander | Mark Buehrle | Mark Buehrle | Justin Verlander | | 15 | 39 | -24 |
| 2008-04-08 | @ BOS | 7 | L 0-5 | 0-7 | 5 | 36,567 | Kenny Rogers | Daisuke Matsuzaka | Daisuke Matsuzaka | Kenny Rogers | | 15 | 44 | -29 |
| 2008-04-09 | @ BOS | 8 | W 7-2 | 1-7 | 5 | 37,190 | Jeremy Bonderman | Jon Lester | Jeremy Bonderman | Jon Lester | | 22 | 46 | -24 |
| 2008-04-10 | @ BOS | 9 | L 6-12 | 1-8 | 5 | 37,612 | Nate Robertson | Tim Wakefield | Tim Wakefield | Nate Robertson | Jonathan Papelbon | 28 | 58 | -30 |
| 2008-04-11 | @ CHA | 10 | W 5-2 | 2-8 | 5 | 26,094 | Dontrelle Willis | Jose Contreras | Aquilino Lopez | Jose Contreras | Todd Jones | 33 | 60 | -27 |
| 2008-04-12 | @ CHA | 11 | L 0-7 | 2-9 | 5 | 29,649 | Justin Verlander | Gavin Floyd | Gavin Floyd | Justin Verlander | | 33 | 67 | -34 |
| 2008-04-13 | @ CHA | 12 | L 0-11 | 2-10 | 5 | 26,294 | Kenny Rogers | Javier Vazquez | Javier Vazquez | Kenny Rogers | | 33 | 78 | -45 |
| 2008-04-14 | vs MIN | 13 | W 11-9 | 3-10 | 5 | 32,002 | Jeremy Bonderman | Nick Blackburn | Francis Beltran | Pat Neshek | Todd Jones | 44 | 87 | -43 |
| 2008-04-15 | vs MIN | 14 | W 6-5 | 4-10 | 5 | 30,901 | Nate Robertson | Scott Baker | Clay Rapada | Jesse Crain | Todd Jones | 50 | 92 | -42 |
| 2008-04-16 | @ CLE | 15 | W 13-2 | 5-10 | 5 | 17,644 | Armando Galarraga | CC Sabathia | Armando Galarraga | CC Sabathia | | 63 | 94 | -31 |
| 2008-04-17 | @ CLE | 16 | L 1-11 | 5-11 | 5 | 21,547 | Justin Verlander | Fausto Carmona | Fausto Carmona | Justin Verlander | | 64 | 105 | -41 |
| 2008-04-18 | @ TOR | 17 | W 8-4 | 6-11 | 5 | 24,294 | Kenny Rogers | David Purcey | Kenny Rogers | Jeremy Accardo | | 72 | 109 | -37 |
| 2008-04-19 | @ TOR | 18 | L 2-3 | 6-12 | 5 | 31,052 | Jeremy Bonderman | Dustin McGowan | Dustin McGowan | Jeremy Bonderman | B.J. Ryan | 74 | 112 | -38 |
| 2008-04-20 | @ TOR | 19 | L 3-5 | 6-13 | 5 | 30,139 | Nate Robertson | A.J. Burnett | A.J. Burnett | Nate Robertson | Jeremy Accardo | 77 | 117 | -40 |
| 2008-04-21 | @ TOR | 20 | W 5-1 | 7-13 | 5 | 25,287 | Armando Galarraga | Shaun Marcum | Armando Galarraga | Shaun Marcum | | 82 | 118 | -36 |
| 2008-04-22 | vs TEX | 21 | W 10-2 | 8-13 | 5 | 33,629 | Justin Verlander | Vicente Padilla | Justin Verlander | Vicente Padilla | | 92 | 120 | -28 |
| 2008-04-23 | vs TEX | 22 | W 19-6 | 9-13 | 4 | 34,245 | Kenny Rogers | Luis Mendoza | Clay Rapada | Frank Francisco | | 111 | 126 | -15 |
| 2008-04-24 | vs TEX | 23 | W 8-2 | 10-13 | 4 | 39,058 | Jeremy Bonderman | Jason Jennings | Zach Miner | Jason Jennings | | 119 | 128 | -9 |
| 2008-04-25 | vs ANA | 24 | L 3-4 | 10-14 | 5 | 40,380 | Nate Robertson | Ervin Santana | Ervin Santana | Nate Robertson | Francisco Rodriguez | 122 | 132 | -10 |
| 2008-04-26 | vs ANA | 25 | W 6-4 | 11-14 | 5 | 42,068 | Armando Galarraga | Dustin Moseley | Aquilino Lopez | Darren O'Day | Todd Jones | 128 | 136 | -8 |
| 2008-04-27 | vs ANA | 26 | L 2-6 | 11-15 | 5 | 36,347 | Justin Verlander | Jered Weaver | Jered Weaver | Justin Verlander | | 130 | 142 | -12 |
| 2008-04-29 | @ NYA | 27 | W 6-4 | 12-15 | 5 | 49,194 | Kenny Rogers | Phil Hughes | Kenny Rogers | Phil Hughes | Todd Jones | 136 | 146 | -10 |
| 2008-04-30 | @ NYA | 28 | W 6-2 | 13-15 | 4 | 49,513 | Jeremy Bonderman | Andy Pettitte | Jeremy Bonderman | Andy Pettitte | | 142 | 148 | -6 |
| 2008-05-01 | @ NYA | 29 | W 8-4 | 14-15 | 3 | 50,993 | Nate Robertson | Ian Kennedy | Nate Robertson | Jonathan Albaladejo | | 150 | 152 | -2 |
| 2008-05-02 | @ MIN | 30 | L 1-11 | 14-16 | 4 | 33,628 | Armando Galarraga | Livan Hernandez | Livan Hernandez | Armando Galarraga | | 151 | 163 | -12 |
| 2008-05-03 | @ MIN | 31 | L 1-4 | 14-17 | 4 | 28,985 | Justin Verlander | Scott Baker | Brian Bass | Justin Verlander | Joe Nathan | 152 | 167 | -15 |
| 2008-05-04 | @ MIN | 32 | L 6-7 | 14-18 | 5 | 29,821 | Kenny Rogers | Boof Bonser | Matt Guerrier | Zach Miner | Joe Nathan | 158 | 174 | -16 |
| 2008-05-05 | vs BOS | 33 | L 3-6 | 14-19 | 5 | 39,478 | Jeremy Bonderman | Daisuke Matsuzaka | Daisuke Matsuzaka | Jeremy Bonderman | Jonathan Papelbon | 161 | 180 | -19 |
| 2008-05-06 | vs BOS | 34 | L 0-5 | 14-20 | 5 | 38,564 | Nate Robertson | Tim Wakefield | Tim Wakefield | Nate Robertson | | 161 | 185 | -24 |
| 2008-05-07 | vs BOS | 35 | W 10-9 | 15-20 | 5 | 38,062 | Armando Galarraga | Clay Buchholz | Todd Jones | Jonathan Papelbon | | 171 | 194 | -23 |
| 2008-05-08 | vs BOS | 36 | L 1-5 | 15-21 | 5 | 38,952 | Justin Verlander | Josh Beckett | Josh Beckett | Justin Verlander | | 172 | 199 | -27 |
| 2008-05-09 | vs NYA | 37 | W 6-5 | 16-21 | 4 | 44,062 | Kenny Rogers | Kei Igawa | Kenny Rogers | Kei Igawa | | 178 | 204 | -26 |
| 2008-05-10 | vs NYA | 38 | L 2-5 | 16-22 | 4 | 44,580 | Jeremy Bonderman | Darrell Rasner | Darrell Rasner | Jeremy Bonderman | Mariano Rivera | 180 | 209 | -29 |
| 2008-05-13 | @ KCA | 39 | L 2-3 | 16-23 | 5 | 11,703 | Nate Robertson | Zack Greinke | Leo Nunez | Francisco Cruceta | Joakim Soria | 182 | 212 | -30 |
| 2008-05-14 | @ KCA | 40 | L 0-2 | 16-24 | 5 | 14,053 | Justin Verlander | Luke Hochevar | Luke Hochevar | Justin Verlander | Joakim Soria | 182 | 214 | -32 |
| 2008-05-15 | @ KCA | 41 | L 4-8 | 16-25 | 5 | 34,734 | Kenny Rogers | Gil Meche | Gil Meche | Kenny Rogers | | 186 | 222 | -36 |
| 2008-05-16 | @ ARI | 42 | L 3-4 | 16-26 | 5 | 33,531 | Jeremy Bonderman | Dan Haren | Dan Haren | Zach Miner | Tony Pena | 189 | 226 | -37 |
| 2008-05-17 | @ ARI | 43 | W 3-2 | 17-26 | 5 | 48,804 | Armando Galarraga | Max Scherzer | Armando Galarraga | Max Scherzer | Todd Jones | 192 | 228 | -36 |
| 2008-05-18 | @ ARI | 44 | L 0-4 | 17-27 | 5 | 38,793 | Nate Robertson | Randy Johnson | Randy Johnson | Nate Robertson | | 192 | 232 | -40 |
| 2008-05-20 | vs SEA | 45 | W 12-8 | 18-27 | 5 | 39,463 | Justin Verlander | Carlos Silva | Justin Verlander | Carlos Silva | Todd Jones | 204 | 240 | -36 |
| 2008-05-21 | vs SEA | 46 | W 9-4 | 19-27 | 5 | 36,495 | Kenny Rogers | Jarrod Washburn | Kenny Rogers | Jarrod Washburn | | 213 | 244 | -31 |
| 2008-05-22 | vs SEA | 47 | W 9-2 | 20-27 | 5 | 40,166 | Jeremy Bonderman | Miguel Batista | Jeremy Bonderman | Miguel Batista | Freddy Dolsi | 222 | 246 | -24 |
| 2008-05-23 | vs MIN | 48 | L 4-9 | 20-28 | 5 | 40,732 | Armando Galarraga | Kevin Slowey | Kevin Slowey | Armando Galarraga | | 226 | 255 | -29 |
| 2008-05-24 | vs MIN | 49 | W 19-3 | 21-28 | 4 | 41,137 | Nate Robertson | Boof Bonser | Nate Robertson | Boof Bonser | | 245 | 258 | -13 |
| 2008-05-25 | vs MIN | 50 | L 1-6 | 21-29 | 4 | 42,413 | Justin Verlander | Glen Perkins | Glen Perkins | Francisco Cruceta | | 246 | 264 | -18 |
| 2008-05-26 | @ ANA | 51 | L 0-1 | 21-30 | 4 | 41,031 | Kenny Rogers | Jon Garland | Jose Arredondo | Freddy Dolsi | | 246 | 265 | -19 |
| 2008-05-27 | @ ANA | 52 | L 2-3 | 21-31 | 4 | 36,569 | Jeremy Bonderman | Ervin Santana | Ervin Santana | Aquilino Lopez | | 248 | 268 | -20 |
| 2008-05-28 | @ ANA | 53 | W 6-2 | 22-31 | 4 | 42,191 | Armando Galarraga | Joe Saunders | Armando Galarraga | Joe Saunders | | 254 | 270 | -16 |
| 2008-05-30 | @ SEA | 54 | W 7-4 | 23-31 | 4 | 34,019 | Nate Robertson | Carlos Silva | Nate Robertson | Carlos Silva | Todd Jones | 261 | 274 | -13 |
| 2008-05-31 | @ SEA | 55 | L 0-5 | 23-32 | 4 | 33,441 | Justin Verlander | Felix Hernandez | Felix Hernandez | Justin Verlander | | 261 | 279 | -18 |
| 2008-06-01 | @ SEA | 56 | W 7-5 | 24-32 | 4 | 38,610 | Jeremy Bonderman | Miguel Batista | Zach Miner | J.J. Putz | | 268 | 284 | -16 |
| 2008-06-02 | @ OAK | 57 | L 2-3 | 24-33 | 4 | 11,772 | Kenny Rogers | Rich Harden | Huston Street | Francisco Cruceta | | 270 | 287 | -17 |
| 2008-06-03 | @ OAK | 58 | L 4-5 | 24-34 | 4 | 10,871 | Dontrelle Willis | Dana Eveland | Chad Gaudin | Bobby Seay | | 274 | 292 | -18 |
| 2008-06-04 | @ OAK | 59 | L 2-10 | 24-35 | 4 | 19,258 | Nate Robertson | Justin Duchscherer | Justin Duchscherer | Nate Robertson | | 276 | 302 | -26 |
| 2008-06-06 | vs CLE | 60 | L 2-4 | 24-36 | 4 | 40,990 | Justin Verlander | Paul Byrd | Paul Byrd | Justin Verlander | Joe Borowski | 278 | 306 | -28 |
| 2008-06-07 | vs CLE | 61 | W 8-4 | 25-36 | 4 | 42,193 | Kenny Rogers | Aaron Laffey | Zach Miner | Masahide Kobayashi | Todd Jones | 286 | 310 | -24 |
| 2008-06-08 | vs CLE | 62 | W 5-2 | 26-36 | 4 | 39,941 | Armando Galarraga | Jeremy Sowers | Armando Galarraga | Jeremy Sowers | Todd Jones | 291 | 312 | -21 |
| 2008-06-09 | vs CLE | 63 | L 2-8 | 26-37 | 4 | 38,440 | Dontrelle Willis | Cliff Lee | Cliff Lee | Dontrelle Willis | | 293 | 320 | -27 |
| 2008-06-10 | vs CHA | 64 | W 6-4 | 27-37 | 4 | 38,295 | Nate Robertson | Jose Contreras | Nate Robertson | Jose Contreras | Todd Jones | 299 | 324 | -25 |
| 2008-06-11 | vs CHA | 65 | W 5-1 | 28-37 | 4 | 38,693 | Justin Verlander | Javier Vazquez | Justin Verlander | Javier Vazquez | | 304 | 325 | -21 |
| 2008-06-12 | vs CHA | 66 | W 2-1 | 29-37 | 4 | 40,297 | Kenny Rogers | Mark Buehrle | Todd Jones | Octavio Dotel | | 306 | 326 | -20 |
| 2008-06-13 | vs LAN | 67 | W 5-0 | 30-37 | 4 | 40,430 | Armando Galarraga | Derek Lowe | Armando Galarraga | Derek Lowe | Freddy Dolsi | 311 | 326 | -15 |
| 2008-06-14 | vs LAN | 68 | W 12-7 | 31-37 | 4 | 42,348 | Eddie Bonine | Brad Penny | Eddie Bonine | Brad Penny | | 323 | 333 | -10 |
| 2008-06-15 | vs LAN | 69 | W 5-4 | 32-37 | 4 | 41,189 | Nate Robertson | Clayton Kershaw | Nate Robertson | Chan Ho Park | Todd Jones | 328 | 337 | -9 |
| 2008-06-16 | @ SFN | 70 | L 6-8 | 32-38 | 4 | 33,317 | Justin Verlander | Tim Lincecum | Keiichi Yabu | Freddy Dolsi | | 334 | 345 | -11 |
| 2008-06-17 | @ SFN | 71 | W 5-1 | 33-38 | 4 | 33,636 | Kenny Rogers | Jonathan Sanchez | Kenny Rogers | Jonathan Sanchez | | 339 | 346 | -7 |
| 2008-06-18 | @ SFN | 72 | W 7-2 | 34-38 | 3 | 38,194 | Armando Galarraga | Barry Zito | Armando Galarraga | Barry Zito | | 346 | 348 | -2 |
| 2008-06-20 | @ SDN | 73 | L 2-6 | 34-39 | 3 | 40,683 | Eddie Bonine | Greg Maddux | Heath Bell | Fernando Rodney | | 348 | 354 | -6 |
| 2008-06-21 | @ SDN | 74 | W 7-5 | 35-39 | 3 | 34,749 | Nate Robertson | Cha-Seung Baek | Nate Robertson | Cha-Seung Baek | Todd Jones | 355 | 359 | -4 |
| 2008-06-22 | @ SDN | 75 | W 5-3 | 36-39 | 3 | 28,779 | Justin Verlander | Randy Wolf | Justin Verlander | Randy Wolf | Todd Jones | 360 | 362 | -2 |
| 2008-06-24 | vs SLN | 76 | L 4-8 | 36-40 | 3 | 44,446 | Kenny Rogers | Braden Looper | Braden Looper | Kenny Rogers | | 364 | 370 | -6 |
| 2008-06-25 | vs SLN | 77 | W 8-7 | 37-40 | 3 | 40,091 | Armando Galarraga | Kyle Lohse | Todd Jones | Kyle McClellan | | 372 | 377 | -5 |
| 2008-06-26 | vs SLN | 78 | W 3-2 | 38-40 | 3 | 41,022 | Nate Robertson | Todd Wellemeyer | Bobby Seay | Mike Parisi | | 375 | 379 | -4 |
| 2008-06-27 | vs COL | 79 | W 7-1 | 39-40 | 3 | 40,842 | Eddie Bonine | Ubaldo Jimenez | Eddie Bonine | Ubaldo Jimenez | | 382 | 380 | 2 |
| 2008-06-28 | vs COL | 80 | W 7-6 | 40-40 | 3 | 42,729 | Justin Verlander | Jeff Francis | Freddy Dolsi | Brian Fuentes | | 389 | 386 | 3 |
| 2008-06-29 | vs COL | 81 | W 4-3 | 41-40 | 3 | 41,305 | Kenny Rogers | Greg Reynolds | Kenny Rogers | Greg Reynolds | Todd Jones | 393 | 389 | 4 |
| 2008-06-30 | @ MIN | 82 | W 5-4 | 42-40 | 3 | 22,196 | Armando Galarraga | Glen Perkins | Casey Fossum | Matt Guerrier | Joel Zumaya | 398 | 393 | 5 |
| 2008-07-01 | @ MIN | 83 | L 4-6 | 42-41 | 3 | 23,754 | Nate Robertson | Scott Baker | Scott Baker | Nate Robertson | Joe Nathan | 402 | 399 | 3 |
| 2008-07-02 | @ MIN | 84 | L 0-7 | 42-42 | 3 | 30,102 | Eddie Bonine | Nick Blackburn | Nick Blackburn | Eddie Bonine | | 402 | 406 | -4 |
| 2008-07-03 | @ SEA | 85 | W 8-4 | 43-42 | 3 | 22,523 | Justin Verlander | Carlos Silva | Justin Verlander | Carlos Silva | Fernando Rodney | 410 | 410 | 0 |
| 2008-07-04 | @ SEA | 86 | L 1-4 | 43-43 | 3 | 30,564 | Kenny Rogers | Erik Bedard | Erik Bedard | Kenny Rogers | Brandon Morrow | 411 | 414 | -3 |
| 2008-07-05 | @ SEA | 87 | L 2-3 | 43-44 | 3 | 30,373 | Armando Galarraga | R.A. Dickey | Miguel Batista | Fernando Rodney | Brandon Morrow | 413 | 417 | -4 |
| 2008-07-06 | @ SEA | 88 | W 2-1 | 44-44 | 3 | 29,083 | Nate Robertson | Ryan Rowland-Smith | Aquilino Lopez | Jamie Burke | Todd Jones | 415 | 418 | -3 |
| 2008-07-08 | vs CLE | 89 | W 9-2 | 45-44 | 3 | 40,443 | Justin Verlander | Jeremy Sowers | Justin Verlander | Jeremy Sowers | | 424 | 420 | 4 |
| 2008-07-09 | vs CLE | 90 | W 8-6 | 46-44 | 3 | 41,062 | Eddie Bonine | Paul Byrd | Todd Jones | Jensen Lewis | | 432 | 426 | 6 |
| 2008-07-10 | vs MIN | 91 | L 6-7 | 46-45 | 3 | 41,952 | Kenny Rogers | Kevin Slowey | Matt Guerrier | Freddy Dolsi | | 438 | 433 | 5 |
| 2008-07-11 | vs MIN | 92 | L 2-3 | 46-46 | 3 | 42,352 | Armando Galarraga | Glen Perkins | Glen Perkins | Armando Galarraga | Joe Nathan | 440 | 436 | 4 |
| 2008-07-12 | vs MIN | 93 | L 5-6 | 46-47 | 3 | 41,301 | Nate Robertson | Scott Baker | Scott Baker | Nate Robertson | Joe Nathan | 445 | 442 | 3 |
| 2008-07-13 | vs MIN | 94 | W 4-2 | 47-47 | 3 | 41,453 | Justin Verlander | Nick Blackburn | Justin Verlander | Nick Blackburn | Todd Jones | 449 | 444 | 5 |
| 2008-07-17 | @ BAL | 95 | W 6-5 | 48-47 | 3 | 23,224 | Kenny Rogers | Garrett Olson | Kenny Rogers | Garrett Olson | Todd Jones | 455 | 449 | 6 |
| 2008-07-18 | @ BAL | 96 | L 4-7 | 48-48 | 3 | 29,111 | Armando Galarraga | Jeremy Guthrie | Jeremy Guthrie | Armando Galarraga | George Sherrill | 459 | 456 | 3 |
| 2008-07-19 | @ BAL | 97 | L 10-11 | 48-49 | 3 | 31,525 | Nate Robertson | Daniel Cabrera | George Sherrill | Freddy Dolsi | | 469 | 467 | 2 |
| 2008-07-20 | @ BAL | 98 | W 5-1 | 49-49 | 3 | 23,278 | Justin Verlander | Brian Burres | Justin Verlander | Brian Burres | | 474 | 468 | 6 |
| 2008-07-21 | @ KCA | 99 | W 19-4 | 50-49 | 3 | 14,137 | Zach Miner | Luke Hochevar | Zach Miner | Luke Hochevar | | 493 | 472 | 21 |
| 2008-07-22 | @ KCA | 100 | W 7-1 | 51-49 | 3 | 22,074 | Kenny Rogers | Kyle Davies | Kenny Rogers | Kyle Davies | | 500 | 473 | 27 |
| 2008-07-23 | @ KCA | 101 | W 7-1 | 52-49 | 3 | 16,594 | Armando Galarraga | Zack Greinke | Armando Galarraga | Zack Greinke | | 507 | 474 | 33 |
| 2008-07-25 | vs CHA | 102 | L 5-6 | 52-50 | 3 | 44,393 | Nate Robertson | Gavin Floyd | D.J. Carrasco | Todd Jones | Bobby Jenks | 512 | 480 | 32 |
| 2008-07-26 | vs CHA | 103 | L 6-7 | 52-51 | 3 | 45,280 | Justin Verlander | John Danks | John Danks | Justin Verlander | Bobby Jenks | 518 | 487 | 31 |
| 2008-07-27 | vs CHA | 104 | W 6-4 | 53-51 | 3 | 41,790 | Zach Miner | Javier Vazquez | Zach Miner | Javier Vazquez | | 524 | 491 | 33 |
| 2008-07-28 | @ CLE | 105 | L 0-5 | 53-52 | 3 | 24,689 | Kenny Rogers | Paul Byrd | Paul Byrd | Kenny Rogers | | 524 | 496 | 28 |
| 2008-07-29 | @ CLE | 106 | W 8-5 | 54-52 | 3 | 30,625 | Armando Galarraga | Matt Ginter | Armando Galarraga | Matt Ginter | | 532 | 501 | 31 |
| 2008-07-30 | @ CLE | 107 | W 14-12 | 55-52 | 3 | 26,596 | Nate Robertson | Cliff Lee | Casey Fossum | Juan Rincon | | 546 | 513 | 33 |
| 2008-07-31 | @ CLE | 108 | L 4-9 | 55-53 | 3 | 34,186 | Justin Verlander | Fausto Carmona | Fausto Carmona | Justin Verlander | | 550 | 522 | 28 |
| 2008-08-01 | @ TBA | 109 | L 2-5 | 55-54 | 3 | 26,403 | Zach Miner | Scott Kazmir | Grant Balfour | Zach Miner | Troy Percival | 552 | 527 | 25 |
| 2008-08-02 | @ TBA | 110 | L 3-9 | 55-55 | 3 | 36,048 | Kenny Rogers | Andy Sonnanstine | Andy Sonnanstine | Kenny Rogers | | 555 | 536 | 19 |
| 2008-08-03 | @ TBA | 111 | L 5-6 | 55-56 | 3 | 33,438 | Armando Galarraga | James Shields | Trever Miller | Fernando Rodney | | 560 | 542 | 18 |
| 2008-08-05 | @ CHA | 112 | L 8-10 | 55-57 | 3 | 35,371 | Nate Robertson | Gavin Floyd | Adam Russell | Joel Zumaya | | 568 | 552 | 16 |
| 2008-08-06 | @ CHA | 113 | L 1-5 | 55-58 | 3 | 34,124 | Justin Verlander | John Danks | John Danks | Justin Verlander | | 569 | 557 | 12 |
| 2008-08-07 | @ CHA | 114 | W 8-3 | 56-58 | 3 | 36,383 | Zach Miner | Javier Vazquez | Zach Miner | Javier Vazquez | Fernando Rodney | 577 | 560 | 17 |
| 2008-08-08 | vs OAK | 115 | L 2-4 | 56-59 | 3 | 41,457 | Kenny Rogers | Dallas Braden | Dallas Braden | Kenny Rogers | Brad Ziegler | 579 | 564 | 15 |
| 2008-08-09 | vs OAK | 116 | W 10-2 | 57-59 | 3 | 41,308 | Armando Galarraga | Dan Meyer | Armando Galarraga | Dan Meyer | | 589 | 566 | 23 |
| 2008-08-10 | vs OAK | 117 | W 6-1 | 58-59 | 3 | 40,743 | Nate Robertson | Greg Smith | Nate Robertson | Greg Smith | Fernando Rodney | 595 | 567 | 28 |
| 2008-08-11 | vs TOR | 118 | L 2-7 | 58-60 | 3 | 39,718 | Justin Verlander | Shaun Marcum | Shaun Marcum | Justin Verlander | | 597 | 574 | 23 |
| 2008-08-12 | vs TOR | 119 | L 4-6 | 58-61 | 3 | 39,790 | Zach Miner | A.J. Burnett | A.J. Burnett | Joel Zumaya | B.J. Ryan | 601 | 580 | 21 |
| 2008-08-13 | vs TOR | 120 | L 3-4 | 58-62 | 3 | 39,073 | Kenny Rogers | David Purcey | David Purcey | Kenny Rogers | Brandon League | 604 | 584 | 20 |
| 2008-08-14 | vs TOR | 121 | W 5-1 | 59-62 | 3 | 41,259 | Armando Galarraga | Jesse Litsch | Armando Galarraga | Jason Frasor | | 609 | 585 | 24 |
| 2008-08-15 | vs BAL | 122 | L 2-11 | 59-63 | 3 | 40,546 | Nate Robertson | Chris Waters | Lance Cormier | Nate Robertson | | 611 | 596 | 15 |
| 2008-08-16 | vs BAL | 123 | W 5-3 | 60-63 | 3 | 41,727 | Justin Verlander | Dennis Sarfate | Justin Verlander | Dennis Sarfate | Fernando Rodney | 616 | 599 | 17 |
| 2008-08-17 | vs BAL | 124 | L 8-16 | 60-64 | 3 | 40,586 | Zach Miner | Garrett Olson | Fernando Cabrera | Casey Fossum | | 624 | 615 | 9 |
| 2008-08-18 | @ TEX | 125 | W 8-7 | 61-64 | 3 | 17,786 | Kenny Rogers | Scott Feldman | Kenny Rogers | Frank Francisco | Fernando Rodney | 632 | 622 | 10 |
| 2008-08-19 | @ TEX | 126 | W 11-3 | 62-64 | 3 | 18,470 | Armando Galarraga | Vicente Padilla | Armando Galarraga | Vicente Padilla | | 643 | 625 | 18 |
| 2008-08-20 | @ TEX | 127 | L 1-9 | 62-65 | 3 | 19,403 | Nate Robertson | Kevin Millwood | Kevin Millwood | Nate Robertson | | 644 | 634 | 10 |
| 2008-08-22 | @ KCA | 128 | W 4-3 | 63-65 | 3 | 18,361 | Justin Verlander | Brian Bannister | Justin Verlander | Brian Bannister | Fernando Rodney | 648 | 637 | 11 |
| 2008-08-23 | @ KCA | 129 | W 4-0 | 64-65 | 3 | 27,346 | Zach Miner | Kyle Davies | Zach Miner | Kyle Davies | | 652 | 637 | 15 |
| 2008-08-24 | @ KCA | 130 | L 3-7 | 64-66 | 3 | 16,663 | Kenny Rogers | Brandon Duckworth | Brandon Duckworth | Kenny Rogers | | 655 | 644 | 11 |
| 2008-08-25 | vs CLE | 131 | L 3-4 | 64-67 | 3 | 39,196 | Armando Galarraga | Zach Jackson | Brendan Donnelly | Gary Glover | Jensen Lewis | 658 | 648 | 10 |
| 2008-08-26 | vs CLE | 132 | L 4-10 | 64-68 | 4 | 38,774 | Chris Lambert | Cliff Lee | Cliff Lee | Chris Lambert | | 662 | 658 | 4 |
| 2008-08-27 | vs CLE | 133 | L 7-9 | 64-69 | 4 | 38,519 | Justin Verlander | Fausto Carmona | Fausto Carmona | Justin Verlander | | 669 | 667 | 2 |
| 2008-08-29 | vs KCA | 134 | W 6-3 | 65-69 | 4 | 40,206 | Zach Miner | Kyle Davies | Zach Miner | Kyle Davies | | 675 | 670 | 5 |
| 2008-08-30 | vs KCA | 135 | L 3-13 | 65-70 | 4 | 40,623 | Kenny Rogers | Brandon Duckworth | Brandon Duckworth | Kenny Rogers | | 678 | 683 | -5 |
| 2008-08-31 | vs KCA | 136 | W 4-2 | 66-70 | 3 | 39,782 | Armando Galarraga | Gil Meche | Gary Glover | Kip Wells | Fernando Rodney | 682 | 685 | -3 |
| 2008-09-01 | vs NYA | 137 | L 9-13 | 66-71 | 4 | 44,336 | Justin Verlander | Sidney Ponson | Brian Bruney | Justin Verlander | | 691 | 698 | -7 |
| 2008-09-02 | vs ANA | 138 | L 4-5 | 66-72 | 4 | 35,320 | Chris Lambert | Joe Saunders | Scot Shields | Fernando Rodney | Francisco Rodriguez | 695 | 703 | -8 |
| 2008-09-03 | vs ANA | 139 | W 9-6 | 67-72 | 4 | 36,671 | Zach Miner | Jon Garland | Kyle Farnsworth | Jose Arredondo | Fernando Rodney | 704 | 709 | -5 |
| 2008-09-04 | vs ANA | 140 | L 1-7 | 67-73 | 4 | 37,890 | Kenny Rogers | Ervin Santana | Ervin Santana | Kenny Rogers | | 705 | 716 | -11 |
| 2008-09-05 | @ MIN | 141 | L 2-10 | 67-74 | 4 | 24,424 | Armando Galarraga | Francisco Liriano | Francisco Liriano | Armando Galarraga | | 707 | 726 | -19 |
| 2008-09-06 | @ MIN | 142 | W 6-4 | 68-74 | 4 | 42,606 | Justin Verlander | Scott Baker | Clay Rapada | Matt Guerrier | Fernando Rodney | 713 | 730 | -17 |
| 2008-09-07 | @ MIN | 143 | W 7-5 | 69-74 | 4 | 31,236 | Chris Lambert | Glen Perkins | Chris Lambert | Glen Perkins | Fernando Rodney | 720 | 735 | -15 |
| 2008-09-08 | vs OAK | 144 | W 14-8 | 70-74 | 3 | 37,981 | Zach Miner | Gio Gonzalez | Casey Fossum | Gio Gonzalez | | 734 | 743 | -9 |
| 2008-09-09 | vs OAK | 145 | L 2-3 | 70-75 | 4 | 37,240 | Nate Robertson | Dana Eveland | Joey Devine | Fernando Rodney | Brad Ziegler | 736 | 746 | -10 |
| 2008-09-10 | vs OAK | 146 | L 2-5 | 70-76 | 4 | 37,194 | Armando Galarraga | Sean Gallagher | Huston Street | Armando Galarraga | Brad Ziegler | 738 | 751 | -13 |
| 2008-09-14 | @ CHA | 147 | L 2-4 | 70-78 | 4 | 0 | Justin Verlander | Javier Vazquez | Javier Vazquez | Justin Verlander | | 740 | 755 | -15 |
| 2008-09-14 | @ CHA | 148 | L 7-11 | 70-78 | 4 | 28,238 | Kenny Rogers | John Danks | Matt Thornton | Bobby Seay | | 747 | 766 | -19 |
| 2008-09-15 | @ TEX | 149 | L 8-11 | 70-79 | 4 | 13,536 | Dontrelle Willis | Brandon McCarthy | Frank Francisco | Kyle Farnsworth | | 755 | 777 | -22 |
| 2008-09-16 | @ TEX | 150 | L 4-5 | 70-80 | 4 | 14,659 | Zach Miner | Kevin Millwood | Jamey Wright | Fernando Rodney | | 759 | 782 | -23 |
| 2008-09-17 | @ TEX | 151 | W 17-4 | 71-80 | 4 | 17,808 | Freddy Garcia | Dustin Nippert | Freddy Garcia | Dustin Nippert | | 776 | 786 | -10 |
| 2008-09-19 | @ CLE | 152 | L 5-6 | 71-81 | 4 | 33,733 | Armando Galarraga | Fausto Carmona | Rafael Perez | Freddy Dolsi | | 781 | 792 | -11 |
| 2008-09-20 | @ CLE | 153 | L 3-6 | 71-82 | 4 | 36,869 | Justin Verlander | Jeremy Sowers | Jeremy Sowers | Justin Verlander | Jensen Lewis | 784 | 798 | -14 |
| 2008-09-21 | @ CLE | 154 | L 5-10 | 71-83 | 4 | 36,957 | Dontrelle Willis | Scott Lewis | Scott Lewis | Dontrelle Willis | | 789 | 808 | -19 |
| 2008-09-22 | vs KCA | 155 | L 2-6 | 71-84 | 4 | 36,482 | Zach Miner | Gil Meche | Gil Meche | Zach Miner | | 791 | 814 | -23 |
| 2008-09-23 | vs KCA | 156 | L 0-5 | 71-85 | 5 | 35,121 | Freddy Garcia | Zack Greinke | Zack Greinke | Freddy Garcia | | 791 | 819 | -28 |
| 2008-09-24 | vs KCA | 157 | L 4-10 | 71-86 | 5 | 35,899 | Nate Robertson | Brian Bannister | Brian Bannister | Nate Robertson | | 795 | 829 | -34 |
| 2008-09-25 | vs TBA | 158 | W 7-5 | 72-86 | 5 | 36,259 | Armando Galarraga | Scott Kazmir | Armando Galarraga | Scott Kazmir | Fernando Rodney | 802 | 834 | -32 |
| 2008-09-26 | vs TBA | 159 | W 6-4 | 73-86 | 5 | 39,617 | Justin Verlander | Andy Sonnanstine | Justin Verlander | Andy Sonnanstine | Fernando Rodney | 808 | 838 | -30 |
| 2008-09-27 | vs TBA | 160 | W 4-3 | 74-86 | 5 | 40,756 | Dontrelle Willis | Matt Garza | Aquilino Lopez | Jeff Niemann | Fernando Rodney | 812 | 841 | -29 |
| 2008-09-28 | vs TBA | 161 | L 7-8 | 74-87 | 5 | 40,373 | Zach Miner | James Shields | Edwin Jackson | Chris Lambert | Jason Hammel | 819 | 849 | -30 |
| 2008-09-29 | @ CHA | 162 | L 2-8 | 74-88 | 5 | 35,923 | Freddy Garcia | Gavin Floyd | Gavin Floyd | Armando Galarraga | | 821 | 857 | -36 |