| 2007-04-02 | vs CHN | 1 | W 5-1 | 1-0 | 1 | 42,720 | Aaron Harang | Carlos Zambrano | Aaron Harang | Carlos Zambrano | | 5 | 1 | 4 |
| 2007-04-04 | vs CHN | 2 | L 1-4 | 1-1 | 4 | 25,965 | Bronson Arroyo | Ted Lilly | Ted Lilly | Bronson Arroyo | Ryan Dempster | 6 | 5 | 1 |
| 2007-04-05 | vs CHN | 3 | W 5-2 | 2-1 | 2 | 25,070 | Kyle Lohse | Jason Marquis | Victor Santos | Bob Howry | David Weathers | 11 | 7 | 4 |
| 2007-04-06 | vs PIT | 4 | W 6-1 | 3-1 | 1 | 17,837 | Matt Belisle | Paul Maholm | Matt Belisle | Paul Maholm | | 17 | 8 | 9 |
| 2007-04-07 | vs PIT | 5 | W 7-5 | 4-1 | 1 | 15,825 | Aaron Harang | Tony Armas | Aaron Harang | Tony Armas | David Weathers | 24 | 13 | 11 |
| 2007-04-08 | vs PIT | 6 | L 3-6 | 4-2 | 1 | 14,001 | Eric Milton | Zach Duke | Zach Duke | Eric Milton | Salomon Torres | 27 | 19 | 8 |
| 2007-04-09 | @ ARI | 7 | L 2-3 | 4-3 | 1 | 41,803 | Bronson Arroyo | Doug Davis | Brandon Lyon | Kirk Saarloos | Jose Valverde | 29 | 22 | 7 |
| 2007-04-10 | @ ARI | 8 | L 4-5 | 4-4 | 1 | 21,225 | Kyle Lohse | Edgar Gonzalez | Juan Cruz | David Weathers | | 33 | 27 | 6 |
| 2007-04-11 | @ ARI | 9 | W 3-2 | 5-4 | 1 | 19,534 | Matt Belisle | Micah Owings | Matt Belisle | Micah Owings | David Weathers | 36 | 29 | 7 |
| 2007-04-13 | @ CHN | 10 | W 6-5 | 6-4 | 1 | 37,267 | Aaron Harang | Carlos Zambrano | Todd Coffey | Carlos Zambrano | David Weathers | 42 | 34 | 8 |
| 2007-04-14 | @ CHN | 11 | L 0-7 | 6-5 | 2 | 38,598 | Bronson Arroyo | Rich Hill | Rich Hill | Bronson Arroyo | | 42 | 41 | 1 |
| 2007-04-15 | @ CHN | 12 | W 1-0 | 7-5 | 1 | 39,820 | Kyle Lohse | Ted Lilly | Kyle Lohse | Ted Lilly | David Weathers | 43 | 41 | 2 |
| 2007-04-16 | vs MIL | 13 | L 6-10 | 7-6 | 2 | 12,521 | Eric Milton | Chris Capuano | Chris Capuano | Eric Milton | | 49 | 51 | -2 |
| 2007-04-17 | vs MIL | 14 | W 11-5 | 8-6 | 1 | 14,492 | Matt Belisle | David Bush | Mike Stanton | Brian Shouse | | 60 | 56 | 4 |
| 2007-04-18 | vs HOU | 15 | L 2-7 | 8-7 | 3 | 13,772 | Aaron Harang | Chris Sampson | Chris Sampson | Todd Coffey | | 62 | 63 | -1 |
| 2007-04-19 | vs HOU | 16 | L 6-8 | 8-8 | 3 | 14,222 | Bronson Arroyo | Woody Williams | Brad Lidge | David Weathers | Dan Wheeler | 68 | 71 | -3 |
| 2007-04-20 | vs PHI | 17 | W 2-1 | 9-8 | 3 | 32,962 | Kyle Lohse | Jon Lieber | Jon Coutlangus | Tom Gordon | | 70 | 72 | -2 |
| 2007-04-21 | vs PHI | 18 | L 1-4 | 9-9 | 3 | 39,353 | Eric Milton | Cole Hamels | Cole Hamels | Eric Milton | | 71 | 76 | -5 |
| 2007-04-22 | vs PHI | 19 | L 3-9 | 9-10 | 3 | 29,717 | Matt Belisle | Freddy Garcia | Freddy Garcia | Matt Belisle | | 74 | 85 | -11 |
| 2007-04-24 | @ SLN | 20 | W 10-3 | 10-10 | 2 | 42,309 | Aaron Harang | Kip Wells | Aaron Harang | Kip Wells | | 84 | 88 | -4 |
| 2007-04-25 | @ SLN | 21 | L 2-5 | 10-11 | 2 | 42,225 | Bronson Arroyo | Braden Looper | Randy Flores | Kirk Saarloos | Jason Isringhausen | 86 | 93 | -7 |
| 2007-04-26 | @ SLN | 22 | L 5-7 | 10-12 | 4 | 42,503 | Kyle Lohse | Randy Keisler | Russ Springer | Kyle Lohse | Jason Isringhausen | 91 | 100 | -9 |
| 2007-04-27 | @ PIT | 23 | L 1-3 | 10-13 | 4 | 22,638 | Eric Milton | Ian Snell | Ian Snell | Eric Milton | Salomon Torres | 92 | 103 | -11 |
| 2007-04-28 | @ PIT | 24 | W 8-1 | 11-13 | 3 | 29,514 | Matt Belisle | Tom Gorzelanny | Matt Belisle | Tom Gorzelanny | | 100 | 104 | -4 |
| 2007-04-29 | @ PIT | 25 | W 9-5 | 12-13 | 2 | 18,409 | Aaron Harang | Paul Maholm | Aaron Harang | Paul Maholm | | 109 | 109 | 0 |
| 2007-05-01 | @ HOU | 26 | W 11-2 | 13-13 | 2 | 30,361 | Bronson Arroyo | Matt Albers | Bronson Arroyo | Matt Albers | | 120 | 111 | 9 |
| 2007-05-02 | @ HOU | 27 | L 1-3 | 13-14 | 2 | 29,468 | Kyle Lohse | Roy Oswalt | Roy Oswalt | Kyle Lohse | Dan Wheeler | 121 | 114 | 7 |
| 2007-05-03 | @ HOU | 28 | L 5-7 | 13-15 | 3 | 29,931 | Eric Milton | Wandy Rodriguez | Chad Qualls | Mike Stanton | Dan Wheeler | 126 | 121 | 5 |
| 2007-05-04 | vs COL | 29 | L 5-6 | 13-16 | 4 | 23,920 | Matt Belisle | Jason Hirsh | Denny Bautista | Mike Stanton | Brian Fuentes | 131 | 127 | 4 |
| 2007-05-05 | vs COL | 30 | L 7-9 | 13-17 | 5 | 26,663 | Aaron Harang | Aaron Cook | Aaron Cook | Aaron Harang | Brian Fuentes | 138 | 136 | 2 |
| 2007-05-06 | vs COL | 31 | W 9-3 | 14-17 | 3 | 27,915 | Bronson Arroyo | Josh Fogg | Bronson Arroyo | Josh Fogg | David Weathers | 147 | 139 | 8 |
| 2007-05-07 | vs HOU | 32 | L 4-5 | 14-18 | 4 | 17,362 | Kyle Lohse | Roy Oswalt | Roy Oswalt | Kyle Lohse | Dan Wheeler | 151 | 144 | 7 |
| 2007-05-08 | vs HOU | 33 | L 6-7 | 14-19 | 5 | 16,264 | Eric Milton | Wandy Rodriguez | Brad Lidge | Brad Salmon | Dan Wheeler | 157 | 151 | 6 |
| 2007-05-09 | vs HOU | 34 | L 2-3 | 14-20 | 6 | 16,278 | Matt Belisle | Woody Williams | Woody Williams | Matt Belisle | Dan Wheeler | 159 | 154 | 5 |
| 2007-05-10 | vs HOU | 35 | W 9-5 | 15-20 | 6 | 25,796 | Aaron Harang | Matt Albers | Aaron Harang | Matt Albers | David Weathers | 168 | 159 | 9 |
| 2007-05-11 | @ LAN | 36 | L 0-2 | 15-21 | 6 | 49,588 | Bronson Arroyo | Randy Wolf | Randy Wolf | Bronson Arroyo | Takashi Saito | 168 | 161 | 7 |
| 2007-05-12 | @ LAN | 37 | L 3-7 | 15-22 | 6 | 51,776 | Kyle Lohse | Brad Penny | Brad Penny | Kyle Lohse | | 171 | 168 | 3 |
| 2007-05-13 | @ LAN | 38 | L 5-10 | 15-23 | 6 | 41,399 | Bobby Livingston | Mark Hendrickson | Jonathan Broxton | Kirk Saarloos | | 176 | 178 | -2 |
| 2007-05-14 | @ SDN | 39 | L 1-7 | 15-24 | 6 | 20,262 | Matt Belisle | Greg Maddux | Greg Maddux | Matt Belisle | | 177 | 185 | -8 |
| 2007-05-15 | @ SDN | 40 | W 2-1 | 16-24 | 6 | 26,694 | Aaron Harang | David Wells | David Weathers | Heath Bell | | 179 | 186 | -7 |
| 2007-05-16 | @ SDN | 41 | L 2-3 | 16-25 | 6 | 23,856 | Bronson Arroyo | Jake Peavy | Trevor Hoffman | Bronson Arroyo | | 181 | 189 | -8 |
| 2007-05-18 | @ CLE | 42 | L 4-9 | 16-26 | 6 | 34,230 | Kyle Lohse | Cliff Lee | Cliff Lee | Kyle Lohse | | 185 | 198 | -13 |
| 2007-05-19 | @ CLE | 43 | W 10-5 | 17-26 | 6 | 35,262 | Matt Belisle | Jeremy Sowers | Matt Belisle | Jeremy Sowers | David Weathers | 195 | 203 | -8 |
| 2007-05-20 | @ CLE | 44 | L 3-5 | 17-27 | 6 | 32,524 | Aaron Harang | Paul Byrd | Paul Byrd | Aaron Harang | Joe Borowski | 198 | 208 | -10 |
| 2007-05-21 | vs WAS | 45 | W 8-7 | 18-27 | 5 | 15,271 | Bronson Arroyo | Levale Speigner | Jon Coutlangus | Jon Rauch | David Weathers | 206 | 215 | -9 |
| 2007-05-22 | vs WAS | 46 | L 4-8 | 18-28 | 6 | 16,732 | Kirk Saarloos | Matt Chico | Jesus Colome | Jon Coutlangus | | 210 | 223 | -13 |
| 2007-05-23 | vs WAS | 47 | L 7-12 | 18-29 | 6 | 31,971 | Kyle Lohse | Jason Simontacchi | Jason Simontacchi | Kyle Lohse | | 217 | 235 | -18 |
| 2007-05-24 | vs WAS | 48 | L 3-4 | 18-30 | 6 | 19,541 | Matt Belisle | Michael Bacsik | Michael Bacsik | Matt Belisle | Chad Cordero | 220 | 239 | -19 |
| 2007-05-25 | vs PIT | 49 | L 4-10 | 18-31 | 6 | 36,455 | Aaron Harang | Paul Maholm | Jonah Bayliss | David Weathers | | 224 | 249 | -25 |
| 2007-05-26 | vs PIT | 50 | L 5-9 | 18-32 | 6 | 32,380 | Bronson Arroyo | Shawn Chacon | John Grabow | Bronson Arroyo | | 229 | 258 | -29 |
| 2007-05-27 | vs PIT | 51 | L 10-14 | 18-33 | 6 | 27,209 | Kirk Saarloos | Zach Duke | Zach Duke | Kirk Saarloos | | 239 | 272 | -33 |
| 2007-05-28 | vs PIT | 52 | W 4-0 | 19-33 | 6 | 17,905 | Kyle Lohse | Ian Snell | Kyle Lohse | Ian Snell | | 243 | 272 | -29 |
| 2007-05-29 | @ HOU | 53 | W 2-1 | 20-33 | 6 | 33,565 | Matt Belisle | Jason Jennings | Matt Belisle | Chad Qualls | David Weathers | 245 | 273 | -28 |
| 2007-05-30 | @ HOU | 54 | W 4-3 | 21-33 | 6 | 31,904 | Aaron Harang | Wandy Rodriguez | Aaron Harang | Wandy Rodriguez | | 249 | 276 | -27 |
| 2007-05-31 | @ HOU | 55 | L 2-10 | 21-34 | 6 | 30,336 | Bronson Arroyo | Woody Williams | Woody Williams | Bronson Arroyo | | 251 | 286 | -35 |
| 2007-06-01 | @ COL | 56 | W 4-2 | 22-34 | 6 | 22,265 | Bobby Livingston | Taylor Buchholz | Bobby Livingston | Taylor Buchholz | David Weathers | 255 | 288 | -33 |
| 2007-06-02 | @ COL | 57 | L 1-4 | 22-35 | 6 | 30,076 | Kyle Lohse | Jeff Francis | Jeff Francis | Kyle Lohse | Brian Fuentes | 256 | 292 | -36 |
| 2007-06-03 | @ COL | 58 | L 9-10 | 22-36 | 6 | 26,071 | Matt Belisle | Rodrigo Lopez | Manuel Corpas | Victor Santos | | 265 | 302 | -37 |
| 2007-06-05 | @ SLN | 59 | L 3-4 | 22-37 | 6 | 43,532 | Aaron Harang | Todd Wellemeyer | Jason Isringhausen | Jared Burton | | 268 | 306 | -38 |
| 2007-06-06 | @ SLN | 60 | L 4-6 | 22-38 | 6 | 42,029 | Bronson Arroyo | Brad Thompson | Tyler Johnson | Bronson Arroyo | Jason Isringhausen | 272 | 312 | -40 |
| 2007-06-07 | @ SLN | 61 | W 5-1 | 23-38 | 6 | 43,597 | Kyle Lohse | Adam Wainwright | Kyle Lohse | Adam Wainwright | | 277 | 313 | -36 |
| 2007-06-08 | vs CLE | 62 | W 4-3 | 24-38 | 6 | 38,696 | Homer Bailey | Cliff Lee | Homer Bailey | Cliff Lee | David Weathers | 281 | 316 | -35 |
| 2007-06-09 | vs CLE | 63 | L 6-8 | 24-39 | 6 | 37,935 | Matt Belisle | Jeremy Sowers | Tom Mastny | Victor Santos | Joe Borowski | 287 | 324 | -37 |
| 2007-06-10 | vs CLE | 64 | W 1-0 | 25-39 | 6 | 30,842 | Aaron Harang | CC Sabathia | Marcus McBeth | Aaron Fultz | | 288 | 324 | -36 |
| 2007-06-12 | vs ANA | 65 | W 5-3 | 26-39 | 6 | 23,153 | Bronson Arroyo | Kelvim Escobar | Jon Coutlangus | Dustin Moseley | David Weathers | 293 | 327 | -34 |
| 2007-06-13 | vs ANA | 66 | L 3-6 | 26-40 | 6 | 29,655 | Kyle Lohse | John Lackey | John Lackey | Kyle Lohse | Francisco Rodriguez | 296 | 333 | -37 |
| 2007-06-14 | vs ANA | 67 | L 7-9 | 26-41 | 6 | 32,860 | Homer Bailey | Bartolo Colon | Bartolo Colon | Gary Majewski | Francisco Rodriguez | 303 | 342 | -39 |
| 2007-06-15 | vs TEX | 68 | L 6-7 | 26-42 | 6 | 27,747 | Matt Belisle | Vicente Padilla | Vicente Padilla | Matt Belisle | Eric Gagne | 309 | 349 | -40 |
| 2007-06-16 | vs TEX | 69 | W 8-4 | 27-42 | 6 | 37,413 | Aaron Harang | Jamey Wright | Aaron Harang | Jamey Wright | | 317 | 353 | -36 |
| 2007-06-17 | vs TEX | 70 | L 4-11 | 27-43 | 6 | 31,162 | Bronson Arroyo | Kevin Millwood | Kevin Millwood | Bronson Arroyo | | 321 | 364 | -43 |
| 2007-06-18 | @ OAK | 71 | L 1-6 | 27-44 | 6 | 16,466 | Kyle Lohse | Joe Blanton | Joe Blanton | Kyle Lohse | | 322 | 370 | -48 |
| 2007-06-19 | @ OAK | 72 | W 5-2 | 28-44 | 6 | 19,351 | Homer Bailey | Chad Gaudin | Homer Bailey | Chad Gaudin | David Weathers | 327 | 372 | -45 |
| 2007-06-20 | @ OAK | 73 | L 3-5 | 28-45 | 6 | 25,872 | Matt Belisle | Dan Haren | Dan Haren | Marcus McBeth | Alan Embree | 330 | 377 | -47 |
| 2007-06-22 | @ SEA | 74 | W 16-1 | 29-45 | 6 | 46,340 | Aaron Harang | Ryan Feierabend | Aaron Harang | Ryan Feierabend | | 346 | 378 | -32 |
| 2007-06-23 | @ SEA | 75 | L 1-9 | 29-46 | 6 | 45,939 | Kyle Lohse | Jarrod Washburn | Jarrod Washburn | Kyle Lohse | | 347 | 387 | -40 |
| 2007-06-24 | @ SEA | 76 | L 2-3 | 29-47 | 6 | 46,064 | Bronson Arroyo | Miguel Batista | Eric O'Flaherty | Bronson Arroyo | J.J. Putz | 349 | 390 | -41 |
| 2007-06-26 | @ PHI | 77 | L 4-11 | 29-48 | 6 | 35,314 | Homer Bailey | Kyle Kendrick | Kyle Kendrick | Homer Bailey | | 353 | 401 | -48 |
| 2007-06-27 | @ PHI | 78 | W 9-6 | 30-48 | 6 | 31,803 | Aaron Harang | Jamie Moyer | Marcus McBeth | Brian Sanches | David Weathers | 362 | 407 | -45 |
| 2007-06-28 | @ PHI | 79 | L 7-8 | 30-49 | 6 | 44,323 | Matt Belisle | Adam Eaton | Clay Condrey | Victor Santos | | 369 | 415 | -46 |
| 2007-06-29 | vs SLN | 80 | L 2-4 | 30-50 | 6 | 35,508 | Bronson Arroyo | Brad Thompson | Troy Percival | Marcus McBeth | Jason Isringhausen | 371 | 419 | -48 |
| 2007-06-30 | vs SLN | 81 | W 5-1 | 31-50 | 6 | 32,538 | Kyle Lohse | Adam Wainwright | Kyle Lohse | Adam Wainwright | | 376 | 420 | -44 |
| 2007-07-01 | vs SLN | 82 | L 7-11 | 31-51 | 6 | 24,126 | Homer Bailey | Mike Maroth | Troy Percival | Homer Bailey | | 383 | 431 | -48 |
| 2007-07-03 | vs SFN | 83 | W 7-3 | 32-51 | 6 | 37,299 | Aaron Harang | Barry Zito | Aaron Harang | Kevin Correia | | 390 | 434 | -44 |
| 2007-07-04 | vs SFN | 84 | L 5-9 | 32-52 | 6 | 24,092 | Matt Belisle | Matt Cain | Matt Cain | Matt Belisle | | 395 | 443 | -48 |
| 2007-07-05 | vs SFN | 85 | W 6-3 | 33-52 | 6 | 30,080 | Bronson Arroyo | Matt Morris | Bronson Arroyo | Matt Morris | David Weathers | 401 | 446 | -45 |
| 2007-07-06 | vs ARI | 86 | W 8-1 | 34-52 | 6 | 20,445 | Kyle Lohse | Micah Owings | Kyle Lohse | Micah Owings | | 409 | 447 | -38 |
| 2007-07-07 | vs ARI | 87 | W 5-4 | 35-52 | 6 | 34,410 | Homer Bailey | Brandon Webb | Jon Coutlangus | Tony Pena | David Weathers | 414 | 451 | -37 |
| 2007-07-08 | vs ARI | 88 | W 4-3 | 36-52 | 6 | 28,169 | Aaron Harang | Yusmeiro Petit | Kirk Saarloos | Jose Valverde | | 418 | 454 | -36 |
| 2007-07-12 | @ NYN | 89 | L 2-3 | 36-53 | 6 | 48,282 | Bronson Arroyo | Orlando Hernandez | Orlando Hernandez | Bronson Arroyo | Billy Wagner | 420 | 457 | -37 |
| 2007-07-13 | @ NYN | 90 | W 8-4 | 37-53 | 6 | 51,305 | Aaron Harang | John Maine | Aaron Harang | John Maine | | 428 | 461 | -33 |
| 2007-07-14 | @ NYN | 91 | L 1-2 | 37-54 | 6 | 51,742 | Matt Belisle | Tom Glavine | Tom Glavine | Mike Stanton | Billy Wagner | 429 | 463 | -34 |
| 2007-07-15 | @ NYN | 92 | L 2-5 | 37-55 | 6 | 52,186 | Kyle Lohse | Oliver Perez | Oliver Perez | Kyle Lohse | Billy Wagner | 431 | 468 | -37 |
| 2007-07-16 | @ ATL | 93 | W 10-3 | 38-55 | 6 | 24,442 | Bobby Livingston | Kyle Davies | Bobby Livingston | Kyle Davies | | 441 | 471 | -30 |
| 2007-07-17 | @ ATL | 94 | W 6-5 | 39-55 | 6 | 30,072 | Bronson Arroyo | Jo-Jo Reyes | Bronson Arroyo | Jo-Jo Reyes | David Weathers | 447 | 476 | -29 |
| 2007-07-18 | @ ATL | 95 | W 5-4 | 40-55 | 5 | 33,789 | Aaron Harang | John Smoltz | Mike Gosling | Jose Ascanio | | 452 | 480 | -28 |
| 2007-07-19 | @ FLO | 96 | W 7-5 | 41-55 | 4 | 10,344 | Matt Belisle | Sergio Mitre | Todd Coffey | Armando Benitez | David Weathers | 459 | 485 | -26 |
| 2007-07-20 | @ FLO | 97 | L 2-10 | 41-56 | 5 | 15,313 | Kyle Lohse | Scott Olsen | Scott Olsen | Kyle Lohse | | 461 | 495 | -34 |
| 2007-07-21 | @ FLO | 98 | L 1-11 | 41-57 | 6 | 21,823 | Bobby Livingston | Byung-Hyun Kim | Byung-Hyun Kim | Bobby Livingston | | 462 | 506 | -44 |
| 2007-07-22 | @ FLO | 99 | L 3-9 | 41-58 | 6 | 14,123 | Bronson Arroyo | Rick Vanden Hurk | Renyel Pinto | Bronson Arroyo | | 465 | 515 | -50 |
| 2007-07-23 | vs MIL | 100 | W 2-1 | 42-58 | 6 | 23,489 | Aaron Harang | Chris Capuano | Jared Burton | Grant Balfour | | 467 | 516 | -49 |
| 2007-07-24 | vs MIL | 101 | L 3-5 | 42-59 | 6 | 18,284 | Matt Belisle | Yovani Gallardo | Yovani Gallardo | Matt Belisle | Francisco Cordero | 470 | 521 | -51 |
| 2007-07-25 | vs MIL | 102 | W 7-3 | 43-59 | 5 | 30,976 | Kyle Lohse | Jeff Suppan | Kyle Lohse | Jeff Suppan | David Weathers | 477 | 524 | -47 |
| 2007-07-26 | vs MIL | 103 | W 6-5 | 44-59 | 5 | 24,170 | Bobby Livingston | David Bush | Jared Burton | Francisco Cordero | | 483 | 529 | -46 |
| 2007-07-27 | vs CHN | 104 | W 5-4 | 45-59 | 5 | 36,635 | Bronson Arroyo | Rich Hill | David Weathers | Bob Howry | | 488 | 533 | -45 |
| 2007-07-28 | vs CHN | 105 | L 1-8 | 45-60 | 5 | 42,365 | Aaron Harang | Sean Marshall | Sean Marshall | Aaron Harang | | 489 | 541 | -52 |
| 2007-07-29 | vs CHN | 106 | L 0-6 | 45-61 | 5 | 33,061 | Matt Belisle | Carlos Zambrano | Carlos Zambrano | Matt Belisle | | 489 | 547 | -58 |
| 2007-07-31 | @ WAS | 107 | L 3-6 | 45-62 | 5 | 20,165 | Bobby Livingston | Matt Chico | Matt Chico | Bobby Livingston | Chad Cordero | 492 | 553 | -61 |
| 2007-08-01 | @ WAS | 108 | L 2-7 | 45-63 | 5 | 28,944 | Bronson Arroyo | John Lannan | John Lannan | Bronson Arroyo | | 494 | 560 | -66 |
| 2007-08-02 | @ WAS | 109 | L 3-7 | 45-64 | 6 | 26,223 | Phil Dumatrait | Michael Bacsik | Michael Bacsik | Phil Dumatrait | | 497 | 567 | -70 |
| 2007-08-03 | @ PIT | 110 | W 13-4 | 46-64 | 5 | 22,874 | Matt Belisle | Ian Snell | Matt Belisle | Ian Snell | | 510 | 571 | -61 |
| 2007-08-04 | @ PIT | 111 | W 9-8 | 47-64 | 5 | 33,466 | Bobby Livingston | Matt Morris | Jared Burton | Matt Capps | David Weathers | 519 | 579 | -60 |
| 2007-08-07 | vs LAN | 112 | W 4-0 | 48-64 | 5 | 22,057 | Bronson Arroyo | Mark Hendrickson | Bronson Arroyo | Mark Hendrickson | | 523 | 579 | -56 |
| 2007-08-08 | vs LAN | 113 | W 1-0 | 49-64 | 5 | 20,462 | Aaron Harang | Chad Billingsley | Aaron Harang | Chad Billingsley | David Weathers | 524 | 579 | -55 |
| 2007-08-09 | vs LAN | 114 | L 4-5 | 49-65 | 5 | 25,965 | Phil Dumatrait | Brett Tomko | Scott Proctor | Victor Santos | Takashi Saito | 528 | 584 | -56 |
| 2007-08-10 | vs SDN | 115 | L 7-12 | 49-66 | 5 | 21,594 | Matt Belisle | Wil Ledezma | Kevin Cameron | David Weathers | | 535 | 596 | -61 |
| 2007-08-11 | vs SDN | 116 | W 8-3 | 50-66 | 5 | 27,381 | Bobby Livingston | Justin Germano | Bobby Livingston | Justin Hampson | | 543 | 599 | -56 |
| 2007-08-12 | vs SDN | 117 | L 4-10 | 50-67 | 5 | 31,297 | Bronson Arroyo | Jake Peavy | Jake Peavy | Bronson Arroyo | | 547 | 609 | -62 |
| 2007-08-14 | @ CHN | 118 | W 6-5 | 51-67 | 5 | 40,750 | Aaron Harang | Carlos Zambrano | Aaron Harang | Carlos Zambrano | David Weathers | 553 | 614 | -61 |
| 2007-08-15 | @ CHN | 119 | W 11-9 | 52-67 | 5 | 40,162 | Phil Dumatrait | Ted Lilly | Bill Bray | Bob Howry | David Weathers | 564 | 623 | -59 |
| 2007-08-16 | @ CHN | 120 | L 4-12 | 52-68 | 5 | 40,372 | Bobby Livingston | Jason Marquis | Jason Marquis | Bobby Livingston | | 568 | 635 | -67 |
| 2007-08-17 | @ MIL | 121 | W 8-3 | 53-68 | 5 | 41,008 | Bronson Arroyo | Jeff Suppan | Bronson Arroyo | Jeff Suppan | | 576 | 638 | -62 |
| 2007-08-18 | @ MIL | 122 | L 4-8 | 53-69 | 5 | 43,087 | Elizardo Ramirez | Claudio Vargas | Claudio Vargas | Elizardo Ramirez | | 580 | 646 | -66 |
| 2007-08-19 | @ MIL | 123 | W 7-6 | 54-69 | 5 | 42,398 | Aaron Harang | Chris Capuano | Bill Bray | Scott Linebrink | David Weathers | 587 | 652 | -65 |
| 2007-08-20 | vs ATL | 124 | L 4-14 | 54-70 | 5 | 24,477 | Phil Dumatrait | Tim Hudson | Tim Hudson | Phil Dumatrait | | 591 | 666 | -75 |
| 2007-08-21 | vs ATL | 125 | W 8-7 | 55-70 | 5 | 21,039 | Bobby Livingston | Jo-Jo Reyes | Bill Bray | Peter Moylan | David Weathers | 599 | 673 | -74 |
| 2007-08-22 | vs ATL | 126 | W 4-2 | 56-70 | 5 | 22,924 | Bronson Arroyo | Lance Cormier | Bronson Arroyo | Lance Cormier | David Weathers | 603 | 675 | -72 |
| 2007-08-23 | vs ATL | 127 | W 9-7 | 57-70 | 4 | 22,052 | Elizardo Ramirez | Buddy Carlyle | Mike Gosling | Bob Wickman | | 612 | 682 | -70 |
| 2007-08-24 | vs FLO | 128 | W 5-3 | 58-70 | 4 | 25,773 | Aaron Harang | Dontrelle Willis | Aaron Harang | Dontrelle Willis | David Weathers | 617 | 685 | -68 |
| 2007-08-25 | vs FLO | 129 | W 11-7 | 59-70 | 4 | 32,288 | Matt Belisle | Sergio Mitre | Matt Belisle | Sergio Mitre | | 628 | 692 | -64 |
| 2007-08-26 | vs FLO | 130 | W 9-3 | 60-70 | 4 | 23,122 | Tom Shearn | Daniel Barone | Tom Shearn | Daniel Barone | | 637 | 695 | -58 |
| 2007-08-28 | @ PIT | 131 | L 4-6 | 60-71 | 4 | 0 | Elizardo Ramirez | Tom Gorzelanny | Tom Gorzelanny | Elizardo Ramirez | Matt Capps | 641 | 701 | -60 |
| 2007-08-28 | @ PIT | 132 | L 2-3 | 60-71 | 4 | 17,669 | Bronson Arroyo | Paul Maholm | Shawn Chacon | Bill Bray | Matt Capps | 643 | 704 | -61 |
| 2007-08-29 | @ PIT | 133 | W 8-0 | 61-71 | 4 | 14,191 | Aaron Harang | Ian Snell | Aaron Harang | Ian Snell | | 651 | 704 | -53 |
| 2007-08-30 | @ PIT | 134 | W 5-4 | 62-71 | 4 | 12,643 | Matt Belisle | Matt Morris | Jared Burton | Matt Capps | David Weathers | 656 | 708 | -52 |
| 2007-08-31 | @ SLN | 135 | L 5-8 | 62-72 | 4 | 43,564 | Tom Shearn | Anthony Reyes | Randy Flores | Gary Majewski | | 661 | 716 | -55 |
| 2007-09-01 | @ SLN | 136 | L 3-11 | 62-73 | 4 | 42,356 | Phil Dumatrait | Adam Wainwright | Adam Wainwright | Phil Dumatrait | | 664 | 727 | -63 |
| 2007-09-02 | @ SLN | 137 | L 2-3 | 62-74 | 4 | 44,223 | Bronson Arroyo | Braden Looper | Braden Looper | Bronson Arroyo | Jason Isringhausen | 666 | 730 | -64 |
| 2007-09-03 | vs NYN | 138 | L 4-10 | 62-75 | 4 | 29,290 | Aaron Harang | Pedro Martinez | Pedro Martinez | Aaron Harang | | 670 | 740 | -70 |
| 2007-09-04 | vs NYN | 139 | L 7-11 | 62-76 | 4 | 20,655 | Matt Belisle | Oliver Perez | Oliver Perez | Bill Bray | | 677 | 751 | -74 |
| 2007-09-05 | vs NYN | 140 | W 7-0 | 63-76 | 4 | 15,704 | Tom Shearn | John Maine | Tom Shearn | John Maine | | 684 | 751 | -67 |
| 2007-09-07 | vs MIL | 141 | W 11-4 | 64-76 | 4 | 21,006 | Bronson Arroyo | David Bush | Bronson Arroyo | David Bush | | 695 | 755 | -60 |
| 2007-09-08 | vs MIL | 142 | L 3-4 | 64-77 | 4 | 22,758 | Aaron Harang | Jeff Suppan | Derrick Turnbow | David Weathers | Francisco Cordero | 698 | 759 | -61 |
| 2007-09-09 | vs MIL | 143 | L 5-10 | 64-78 | 4 | 21,534 | Phil Dumatrait | Ben Sheets | Ben Sheets | Phil Dumatrait | | 703 | 769 | -66 |
| 2007-09-11 | vs SLN | 144 | W 7-2 | 65-78 | 4 | 14,027 | Matt Belisle | Mark Mulder | Matt Belisle | Mark Mulder | | 710 | 771 | -61 |
| 2007-09-12 | vs SLN | 145 | W 5-1 | 66-78 | 4 | 16,167 | Bronson Arroyo | Anthony Reyes | Bronson Arroyo | Anthony Reyes | | 715 | 772 | -57 |
| 2007-09-13 | vs SLN | 146 | W 5-4 | 67-78 | 4 | 18,018 | Aaron Harang | Kip Wells | Aaron Harang | Kip Wells | David Weathers | 720 | 776 | -56 |
| 2007-09-14 | @ MIL | 147 | W 6-5 | 68-78 | 4 | 42,944 | Tom Shearn | Ben Sheets | Tom Shearn | Ben Sheets | Bill Bray | 726 | 781 | -55 |
| 2007-09-15 | @ MIL | 148 | L 3-5 | 68-79 | 4 | 40,710 | Kirk Saarloos | Jeff Suppan | Jeff Suppan | Kirk Saarloos | Francisco Cordero | 729 | 786 | -57 |
| 2007-09-16 | @ MIL | 149 | L 2-5 | 68-80 | 4 | 31,150 | Matt Belisle | Carlos Villanueva | Carlos Villanueva | Matt Belisle | Francisco Cordero | 731 | 791 | -60 |
| 2007-09-17 | @ CHN | 150 | L 6-7 | 68-81 | 4 | 39,075 | Bronson Arroyo | Rich Hill | Will Ohman | David Weathers | | 737 | 798 | -61 |
| 2007-09-18 | @ CHN | 151 | W 5-2 | 69-81 | 4 | 40,801 | Aaron Harang | Carlos Zambrano | Aaron Harang | Carlos Zambrano | David Weathers | 742 | 800 | -58 |
| 2007-09-19 | @ CHN | 152 | L 2-3 | 69-82 | 4 | 40,805 | Tom Shearn | Ted Lilly | Bob Howry | Gary Majewski | | 744 | 803 | -59 |
| 2007-09-20 | @ SFN | 153 | W 4-2 | 70-82 | 4 | 35,019 | Homer Bailey | Matt Cain | Homer Bailey | Matt Cain | David Weathers | 748 | 805 | -57 |
| 2007-09-21 | @ SFN | 154 | W 9-8 | 71-82 | 3 | 35,502 | Matt Belisle | Pat Misch | Marcus McBeth | Scott Munter | David Weathers | 757 | 813 | -56 |
| 2007-09-22 | @ SFN | 155 | L 0-2 | 71-83 | 4 | 36,375 | Bronson Arroyo | Kevin Correia | Brad Hennessey | Bill Bray | Brian Wilson | 757 | 815 | -58 |
| 2007-09-23 | @ SFN | 156 | L 4-5 | 71-84 | 4 | 38,029 | Aaron Harang | Travis Blackley | Randy Messenger | Aaron Harang | Brian Wilson | 761 | 820 | -59 |
| 2007-09-25 | vs HOU | 157 | L 5-8 | 71-85 | 4 | 13,261 | Homer Bailey | Felipe Paulino | Felipe Paulino | Jon Coutlangus | Brad Lidge | 766 | 828 | -62 |
| 2007-09-26 | vs HOU | 158 | L 6-7 | 71-86 | 4 | 13,138 | Tom Shearn | Juan Gutierrez | Dennis Sarfate | Jared Burton | Chad Qualls | 772 | 835 | -63 |
| 2007-09-27 | vs HOU | 159 | L 3-4 | 71-87 | 4 | 13,626 | Matt Belisle | Wandy Rodriguez | Dave Borkowski | Gary Majewski | Brad Lidge | 775 | 839 | -64 |
| 2007-09-28 | vs CHN | 160 | L 0-6 | 71-88 | 4 | 32,193 | Bronson Arroyo | Carlos Zambrano | Carlos Zambrano | Bronson Arroyo | | 775 | 845 | -70 |
| 2007-09-29 | vs CHN | 161 | L 0-4 | 71-89 | 5 | 38,936 | Aaron Harang | Rich Hill | Rich Hill | Aaron Harang | | 775 | 849 | -74 |
| 2007-09-30 | vs CHN | 162 | W 8-4 | 72-89 | 5 | 32,620 | Homer Bailey | Ted Lilly | Homer Bailey | Ryan Dempster | | 783 | 853 | -70 |