| East | W | L | Pct | GB |
| Boston | 96 | 66 | .593 | -- |
| NY Yankees | 94 | 68 | .580 | 2.0 |
| Toronto | 83 | 79 | .512 | 13.0 |
| Baltimore | 69 | 93 | .426 | 27.0 |
| Tampa Bay | 66 | 96 | .407 | 30.0 |
| Player | Age | P | C | 1B | 2B | 3B | SS | LF | CF | RF | OF | DH | P % | C % | 1B % | 2B % | 3B % | SS % | LF % | CF % | RF % | OF % | PO | A | E |
| Jeff Bailey | 28 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -- | -- | 1.000 | -- | -- | -- | -- | -- | -- | -- | 16 | 2 | 0 |
| Josh Beckett | 27 | 30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | .937 | -- | -- | -- | -- | -- | -- | -- | -- | -- | 18 | 12 | 2 |
| Clay Buchholz | 22 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | .800 | -- | -- | -- | -- | -- | -- | -- | -- | -- | 1 | 3 | 1 |
| Kevin Cash | 29 | 0 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -- | .985 | -- | -- | -- | -- | -- | -- | -- | -- | 56 | 8 | 1 |
| Royce Clayton | 37 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 3 | -- | -- | -- | -- | 1.000 | .750 | -- | -- | -- | -- | 0 | 5 | 1 |
| Alex Cora | 31 | 0 | 0 | 1 | 47 | 0 | 33 | 0 | 0 | 0 | 0 | 5 | -- | -- | .500 | .994 | -- | .969 | -- | -- | -- | -- | 93 | 164 | 5 |
| Bryan Corey | 33 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.000 | -- | -- | -- | -- | -- | -- | -- | -- | -- | 0 | 4 | 0 |
| Coco Crisp | 27 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 144 | 0 | 0 | 0 | -- | -- | -- | -- | -- | -- | -- | .998 | -- | -- | 408 | 7 | 1 |
| Manny Delcarmen | 25 | 44 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.000 | -- | -- | -- | -- | -- | -- | -- | -- | -- | 2 | 6 | 0 |
| Brendan Donnelly | 35 | 27 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.000 | -- | -- | -- | -- | -- | -- | -- | -- | -- | 0 | 1 | 0 |
| J.D. Drew | 31 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 133 | 0 | 1 | -- | -- | -- | -- | -- | -- | -- | .923 | .977 | -- | 224 | 3 | 6 |
| Jacoby Ellsbury | 23 | 0 | 0 | 0 | 0 | 0 | 0 | 22 | 16 | 1 | 0 | 0 | -- | -- | -- | -- | -- | -- | 1.000 | 1.000 | -- | -- | 75 | 0 | 0 |
| Kason Gabbard | 25 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.000 | -- | -- | -- | -- | -- | -- | -- | -- | -- | 2 | 8 | 0 |
| Eric Gagne | 31 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.000 | -- | -- | -- | -- | -- | -- | -- | -- | -- | 2 | 2 | 0 |
| Devern Hansack | 29 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.000 | -- | -- | -- | -- | -- | -- | -- | -- | -- | 0 | 2 | 0 |
| Eric Hinske | 29 | 0 | 0 | 43 | 0 | 0 | 0 | 24 | 0 | 12 | 0 | 3 | -- | -- | .989 | -- | -- | -- | 1.000 | -- | 1.000 | -- | 298 | 23 | 3 |
| Bobby Kielty | 30 | 0 | 0 | 0 | 0 | 0 | 0 | 10 | 0 | 10 | 0 | 0 | -- | -- | -- | -- | -- | -- | 1.000 | -- | 1.000 | -- | 28 | 1 | 0 |
| Jon Lester | 23 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | .909 | -- | -- | -- | -- | -- | -- | -- | -- | -- | 6 | 4 | 1 |
| Javier Lopez | 29 | 61 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.000 | -- | -- | -- | -- | -- | -- | -- | -- | -- | 5 | 6 | 0 |
| Mike Lowell | 33 | 0 | 0 | 0 | 0 | 154 | 0 | 0 | 0 | 0 | 0 | 0 | -- | -- | -- | -- | .961 | -- | -- | -- | -- | -- | 105 | 264 | 15 |
| Julio Lugo | 31 | 0 | 0 | 0 | 0 | 0 | 145 | 0 | 0 | 0 | 0 | 1 | -- | -- | -- | -- | -- | .968 | -- | -- | -- | -- | 214 | 360 | 19 |
| Daisuke Matsuzaka | 26 | 32 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.000 | -- | -- | -- | -- | -- | -- | -- | -- | -- | 11 | 23 | 0 |
| Doug Mirabelli | 36 | 0 | 46 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | -- | .995 | -- | -- | -- | -- | -- | -- | -- | -- | 194 | 19 | 1 |
| Brandon Moss | 23 | 0 | 0 | 0 | 0 | 0 | 0 | 13 | 0 | 4 | 0 | 0 | -- | -- | -- | -- | -- | -- | 1.000 | -- | 1.000 | -- | 12 | 1 | 0 |
| David Murphy | 25 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | -- | -- | -- | -- | -- | -- | 1.000 | -- | 1.000 | -- | 2 | 0 | 0 |
| Hideki Okajima | 31 | 66 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.000 | -- | -- | -- | -- | -- | -- | -- | -- | -- | 1 | 11 | 0 |
| David Ortiz | 31 | 0 | 0 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 140 | -- | -- | 1.000 | -- | -- | -- | -- | -- | -- | -- | 37 | 3 | 0 |
| Jonathan Papelbon | 26 | 59 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.000 | -- | -- | -- | -- | -- | -- | -- | -- | -- | 4 | 0 | 0 |
| Dustin Pedroia | 23 | 0 | 0 | 0 | 137 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | -- | -- | -- | .990 | -- | -- | -- | -- | -- | -- | 259 | 360 | 6 |
| Wily Mo Pena | 25 | 0 | 0 | 0 | 0 | 0 | 0 | 22 | 12 | 36 | 0 | 2 | -- | -- | -- | -- | -- | -- | 1.000 | .926 | .977 | -- | 79 | 3 | 3 |
| Joel Pineiro | 28 | 31 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.000 | -- | -- | -- | -- | -- | -- | -- | -- | -- | 3 | 7 | 0 |
| Manny Ramirez | 35 | 0 | 0 | 0 | 0 | 0 | 0 | 120 | 0 | 0 | 0 | 11 | -- | -- | -- | -- | -- | -- | .990 | -- | -- | -- | 182 | 8 | 2 |
| J.C. Romero | 31 | 23 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | .833 | -- | -- | -- | -- | -- | -- | -- | -- | -- | 2 | 3 | 1 |
| Curt Schilling | 40 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.000 | -- | -- | -- | -- | -- | -- | -- | -- | -- | 12 | 9 | 0 |
| Kyle Snyder | 29 | 46 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | .917 | -- | -- | -- | -- | -- | -- | -- | -- | -- | 4 | 7 | 1 |
| Julian Tavarez | 34 | 34 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | .952 | -- | -- | -- | -- | -- | -- | -- | -- | -- | 11 | 9 | 1 |
| Mike Timlin | 41 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | .867 | -- | -- | -- | -- | -- | -- | -- | -- | -- | 4 | 9 | 2 |
| Jason Varitek | 35 | 0 | 125 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -- | .994 | -- | -- | -- | -- | -- | -- | -- | -- | 937 | 39 | 6 |
| Tim Wakefield | 40 | 31 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.000 | -- | -- | -- | -- | -- | -- | -- | -- | -- | 14 | 22 | 0 |
| Kevin Youkilis | 28 | 0 | 0 | 135 | 0 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | -- | -- | 1.000 | -- | .921 | -- | -- | -- | -- | -- | 995 | 120 | 3 |