| 2007-04-02 | @ KCA | 1 | L 1-7 | 0-1 | 4 | 41,257 | Curt Schilling | Gil Meche | Gil Meche | Curt Schilling | | 1 | 7 | -6 |
| 2007-04-04 | @ KCA | 2 | W 7-1 | 1-1 | 2 | 22,348 | Josh Beckett | Odalis Perez | Josh Beckett | Odalis Perez | | 8 | 8 | 0 |
| 2007-04-05 | @ KCA | 3 | W 4-1 | 2-1 | 1 | 23,170 | Daisuke Matsuzaka | Zack Greinke | Daisuke Matsuzaka | Zack Greinke | Jonathan Papelbon | 12 | 9 | 3 |
| 2007-04-06 | @ TEX | 4 | L 0-2 | 2-2 | 2 | 51,548 | Tim Wakefield | Rob Tejeda | Rob Tejeda | Tim Wakefield | Akinori Otsuka | 12 | 11 | 1 |
| 2007-04-07 | @ TEX | 5 | L 4-8 | 2-3 | 4 | 40,865 | Julian Tavarez | Kevin Millwood | Kevin Millwood | Julian Tavarez | | 16 | 19 | -3 |
| 2007-04-08 | @ TEX | 6 | W 3-2 | 3-3 | 2 | 28,347 | Curt Schilling | Vicente Padilla | Curt Schilling | Vicente Padilla | Jonathan Papelbon | 19 | 21 | -2 |
| 2007-04-10 | vs SEA | 7 | W 14-3 | 4-3 | 1 | 35,847 | Josh Beckett | Jeff Weaver | Josh Beckett | Jeff Weaver | | 33 | 24 | 9 |
| 2007-04-11 | vs SEA | 8 | L 0-3 | 4-4 | 2 | 36,630 | Daisuke Matsuzaka | Felix Hernandez | Felix Hernandez | Daisuke Matsuzaka | | 33 | 27 | 6 |
| 2007-04-13 | vs ANA | 9 | W 10-1 | 5-4 | 2 | 35,946 | Tim Wakefield | John Lackey | Tim Wakefield | John Lackey | | 43 | 28 | 15 |
| 2007-04-14 | vs ANA | 10 | W 8-0 | 6-4 | 1 | 36,300 | Curt Schilling | Hector Carrasco | Curt Schilling | Hector Carrasco | | 51 | 28 | 23 |
| 2007-04-16 | vs ANA | 11 | W 7-2 | 7-4 | 1 | 35,424 | Josh Beckett | Ervin Santana | Josh Beckett | Ervin Santana | | 58 | 30 | 28 |
| 2007-04-17 | @ TOR | 12 | L 1-2 | 7-5 | 2 | 42,162 | Daisuke Matsuzaka | Gustavo Chacin | Gustavo Chacin | Daisuke Matsuzaka | Jason Frasor | 59 | 32 | 27 |
| 2007-04-18 | @ TOR | 13 | W 4-1 | 8-5 | 1 | 20,188 | Tim Wakefield | Tomo Ohka | Tim Wakefield | Tomo Ohka | Jonathan Papelbon | 63 | 33 | 30 |
| 2007-04-19 | @ TOR | 14 | W 5-3 | 9-5 | 1 | 33,297 | Julian Tavarez | Roy Halladay | Mike Timlin | Shaun Marcum | Jonathan Papelbon | 68 | 36 | 32 |
| 2007-04-20 | vs NYA | 15 | W 7-6 | 10-5 | 1 | 36,786 | Curt Schilling | Andy Pettitte | Kyle Snyder | Mariano Rivera | Hideki Okajima | 75 | 42 | 33 |
| 2007-04-21 | vs NYA | 16 | W 7-5 | 11-5 | 1 | 36,342 | Josh Beckett | Jeff Karstens | Josh Beckett | Jeff Karstens | Jonathan Papelbon | 82 | 47 | 35 |
| 2007-04-22 | vs NYA | 17 | W 7-6 | 12-5 | 1 | 36,905 | Daisuke Matsuzaka | Chase Wright | Daisuke Matsuzaka | Scott Proctor | Jonathan Papelbon | 89 | 53 | 36 |
| 2007-04-23 | vs TOR | 18 | L 3-7 | 12-6 | 1 | 36,669 | Tim Wakefield | Tomo Ohka | Tomo Ohka | Tim Wakefield | Jason Frasor | 92 | 60 | 32 |
| 2007-04-24 | vs TOR | 19 | L 3-10 | 12-7 | 1 | 37,161 | Julian Tavarez | Roy Halladay | Roy Halladay | Julian Tavarez | | 95 | 70 | 25 |
| 2007-04-25 | @ BAL | 20 | W 6-1 | 13-7 | 1 | 27,613 | Curt Schilling | Daniel Cabrera | Curt Schilling | Daniel Cabrera | | 101 | 71 | 30 |
| 2007-04-26 | @ BAL | 21 | W 5-2 | 14-7 | 1 | 33,522 | Josh Beckett | Adam Loewen | Josh Beckett | Chris Ray | Jonathan Papelbon | 106 | 73 | 33 |
| 2007-04-27 | @ NYA | 22 | W 11-4 | 15-7 | 1 | 55,005 | Daisuke Matsuzaka | Andy Pettitte | Daisuke Matsuzaka | Andy Pettitte | | 117 | 77 | 40 |
| 2007-04-28 | @ NYA | 23 | L 1-3 | 15-8 | 1 | 55,026 | Tim Wakefield | Jeff Karstens | Kei Igawa | Tim Wakefield | Mariano Rivera | 118 | 80 | 38 |
| 2007-04-29 | @ NYA | 24 | W 7-4 | 16-8 | 1 | 54,856 | Julian Tavarez | Chien-Ming Wang | Julian Tavarez | Chien-Ming Wang | Jonathan Papelbon | 125 | 84 | 41 |
| 2007-05-01 | vs OAK | 25 | L 4-5 | 16-9 | 1 | 37,052 | Curt Schilling | Joe Blanton | Justin Duchscherer | Brendan Donnelly | Huston Street | 129 | 89 | 40 |
| 2007-05-02 | vs OAK | 26 | W 6-4 | 17-9 | 1 | 37,006 | Josh Beckett | Chad Gaudin | Josh Beckett | Jay Marshall | Mike Timlin | 135 | 93 | 42 |
| 2007-05-03 | vs SEA | 27 | W 8-7 | 18-9 | 1 | 37,216 | Daisuke Matsuzaka | Horacio Ramirez | Brendan Donnelly | Chris Reitsma | J.C. Romero | 143 | 100 | 43 |
| 2007-05-04 | @ MIN | 28 | W 2-0 | 19-9 | 1 | 34,951 | Tim Wakefield | Carlos Silva | Tim Wakefield | Carlos Silva | Jonathan Papelbon | 145 | 100 | 45 |
| 2007-05-05 | @ MIN | 29 | L 1-2 | 19-10 | 1 | 40,088 | Julian Tavarez | Johan Santana | Johan Santana | Julian Tavarez | Joe Nathan | 146 | 102 | 44 |
| 2007-05-06 | @ MIN | 30 | W 4-3 | 20-10 | 1 | 27,807 | Curt Schilling | Sidney Ponson | Curt Schilling | Sidney Ponson | Jonathan Papelbon | 150 | 105 | 45 |
| 2007-05-08 | @ TOR | 31 | W 9-2 | 21-10 | 1 | 41,203 | Josh Beckett | Victor Zambrano | Josh Beckett | Victor Zambrano | | 159 | 107 | 52 |
| 2007-05-09 | @ TOR | 32 | W 9-3 | 22-10 | 1 | 21,784 | Daisuke Matsuzaka | Tomo Ohka | Daisuke Matsuzaka | Tomo Ohka | | 168 | 110 | 58 |
| 2007-05-10 | @ TOR | 33 | W 8-0 | 23-10 | 1 | 22,290 | Tim Wakefield | Roy Halladay | Tim Wakefield | Roy Halladay | | 176 | 110 | 66 |
| 2007-05-11 | vs BAL | 34 | L 3-6 | 23-11 | 1 | 37,039 | Julian Tavarez | Brian Burres | Brian Burres | Julian Tavarez | Chris Ray | 179 | 116 | 63 |
| 2007-05-12 | vs BAL | 35 | W 13-4 | 24-11 | 1 | 36,503 | Curt Schilling | Steve Trachsel | Javier Lopez | Jon Leicester | | 192 | 120 | 72 |
| 2007-05-13 | vs BAL | 36 | W 6-5 | 25-11 | 1 | 36,379 | Josh Beckett | Jeremy Guthrie | J.C. Romero | Chris Ray | | 198 | 125 | 73 |
| 2007-05-14 | vs DET | 37 | W 7-1 | 26-11 | 1 | 36,935 | Daisuke Matsuzaka | Nate Robertson | Daisuke Matsuzaka | Nate Robertson | | 205 | 126 | 79 |
| 2007-05-15 | vs DET | 38 | L 2-7 | 26-12 | 1 | 37,031 | Tim Wakefield | Justin Verlander | Justin Verlander | Tim Wakefield | | 207 | 133 | 74 |
| 2007-05-17 | vs DET | 39 | W 2-1 | 27-12 | 1 | 36,767 | Julian Tavarez | Zach Miner | Julian Tavarez | Zach Miner | Jonathan Papelbon | 209 | 134 | 75 |
| 2007-05-17 | vs DET | 40 | W 4-2 | 27-12 | 1 | 37,006 | Curt Schilling | Chad Durbin | Brendan Donnelly | Wil Ledezma | Hideki Okajima | 213 | 136 | 77 |
| 2007-05-19 | vs ATL | 41 | W 13-3 | 27-13 | 1 | 36,358 | Daisuke Matsuzaka | Anthony Lerew | Daisuke Matsuzaka | Anthony Lerew | | 226 | 139 | 87 |
| 2007-05-19 | vs ATL | 42 | L 0-14 | 27-13 | 1 | 36,792 | Devern Hansack | John Smoltz | John Smoltz | Devern Hansack | | 226 | 153 | 73 |
| 2007-05-20 | vs ATL | 43 | W 6-3 | 29-12 | 1 | 36,140 | Kason Gabbard | Tim Hudson | Kason Gabbard | Tim Hudson | | 232 | 156 | 76 |
| 2007-05-21 | @ NYA | 44 | L 2-6 | 29-13 | 1 | 55,078 | Tim Wakefield | Chien-Ming Wang | Chien-Ming Wang | Tim Wakefield | | 234 | 162 | 72 |
| 2007-05-22 | @ NYA | 45 | W 7-3 | 30-13 | 1 | 54,739 | Julian Tavarez | Mike Mussina | Julian Tavarez | Mike Mussina | | 241 | 165 | 76 |
| 2007-05-23 | @ NYA | 46 | L 3-8 | 30-14 | 1 | 55,000 | Curt Schilling | Andy Pettitte | Andy Pettitte | Curt Schilling | | 244 | 173 | 71 |
| 2007-05-25 | @ TEX | 47 | W 10-6 | 31-14 | 1 | 33,552 | Daisuke Matsuzaka | Brandon McCarthy | Daisuke Matsuzaka | Wes Littleton | | 254 | 179 | 75 |
| 2007-05-26 | @ TEX | 48 | W 7-4 | 32-14 | 1 | 37,974 | Tim Wakefield | Vicente Padilla | Tim Wakefield | Vicente Padilla | Jonathan Papelbon | 261 | 183 | 78 |
| 2007-05-27 | @ TEX | 49 | W 6-5 | 33-14 | 1 | 40,323 | Julian Tavarez | Kameron Loe | Joel Pineiro | Akinori Otsuka | Hideki Okajima | 267 | 188 | 79 |
| 2007-05-28 | vs CLE | 50 | W 5-3 | 34-14 | 1 | 36,910 | Curt Schilling | Cliff Lee | Curt Schilling | Cliff Lee | Jonathan Papelbon | 272 | 191 | 81 |
| 2007-05-29 | vs CLE | 51 | W 4-2 | 35-14 | 1 | 37,076 | Josh Beckett | Jeremy Sowers | Josh Beckett | Jeremy Sowers | Hideki Okajima | 276 | 193 | 83 |
| 2007-05-30 | vs CLE | 52 | L 4-8 | 35-15 | 1 | 37,091 | Daisuke Matsuzaka | Paul Byrd | Paul Byrd | Daisuke Matsuzaka | | 280 | 201 | 79 |
| 2007-06-01 | vs NYA | 53 | L 5-9 | 35-16 | 1 | 36,785 | Tim Wakefield | Chien-Ming Wang | Chien-Ming Wang | Tim Wakefield | | 285 | 210 | 75 |
| 2007-06-02 | vs NYA | 54 | W 11-6 | 36-16 | 1 | 36,294 | Curt Schilling | Mike Mussina | Hideki Okajima | Scott Proctor | | 296 | 216 | 80 |
| 2007-06-03 | vs NYA | 55 | L 5-6 | 36-17 | 1 | 36,793 | Josh Beckett | Andy Pettitte | Brian Bruney | Jonathan Papelbon | Mariano Rivera | 301 | 222 | 79 |
| 2007-06-04 | @ OAK | 56 | L 4-5 | 36-18 | 1 | 28,177 | Julian Tavarez | Dan Haren | Santiago Casilla | Kyle Snyder | | 305 | 227 | 78 |
| 2007-06-05 | @ OAK | 57 | L 0-2 | 36-19 | 1 | 31,127 | Daisuke Matsuzaka | Lenny DiNardo | Lenny DiNardo | Daisuke Matsuzaka | Alan Embree | 305 | 229 | 76 |
| 2007-06-06 | @ OAK | 58 | L 2-3 | 36-20 | 1 | 32,280 | Tim Wakefield | Joe Kennedy | Joe Kennedy | Tim Wakefield | Santiago Casilla | 307 | 232 | 75 |
| 2007-06-07 | @ OAK | 59 | W 1-0 | 37-20 | 1 | 31,211 | Curt Schilling | Joe Blanton | Curt Schilling | Joe Blanton | | 308 | 232 | 76 |
| 2007-06-08 | @ ARI | 60 | W 10-3 | 38-20 | 1 | 40,435 | Josh Beckett | Doug Davis | Josh Beckett | Doug Davis | | 318 | 235 | 83 |
| 2007-06-09 | @ ARI | 61 | W 4-3 | 39-20 | 1 | 49,826 | Julian Tavarez | Micah Owings | Hideki Okajima | Juan Cruz | Jonathan Papelbon | 322 | 238 | 84 |
| 2007-06-10 | @ ARI | 62 | L 1-5 | 39-21 | 1 | 46,622 | Daisuke Matsuzaka | Randy Johnson | Randy Johnson | Daisuke Matsuzaka | | 323 | 243 | 80 |
| 2007-06-12 | vs COL | 63 | W 2-1 | 40-21 | 1 | 37,008 | Tim Wakefield | Aaron Cook | Tim Wakefield | Aaron Cook | Jonathan Papelbon | 325 | 244 | 81 |
| 2007-06-13 | vs COL | 64 | L 2-12 | 40-22 | 1 | 36,808 | Curt Schilling | Josh Fogg | Josh Fogg | Curt Schilling | | 327 | 256 | 71 |
| 2007-06-14 | vs COL | 65 | L 1-7 | 40-23 | 1 | 36,939 | Josh Beckett | Jeff Francis | Jeff Francis | Josh Beckett | | 328 | 263 | 65 |
| 2007-06-15 | vs SFN | 66 | W 10-2 | 41-23 | 1 | 36,508 | Julian Tavarez | Barry Zito | Julian Tavarez | Barry Zito | | 338 | 265 | 73 |
| 2007-06-16 | vs SFN | 67 | W 1-0 | 42-23 | 1 | 36,381 | Daisuke Matsuzaka | Matt Cain | Daisuke Matsuzaka | Matt Cain | Jonathan Papelbon | 339 | 265 | 74 |
| 2007-06-17 | vs SFN | 68 | W 9-5 | 43-23 | 1 | 36,137 | Tim Wakefield | Matt Morris | Tim Wakefield | Matt Morris | | 348 | 270 | 78 |
| 2007-06-18 | @ ATL | 69 | L 4-9 | 43-24 | 1 | 47,562 | Curt Schilling | Chuck James | Chuck James | Curt Schilling | | 352 | 279 | 73 |
| 2007-06-19 | @ ATL | 70 | W 4-0 | 44-24 | 1 | 47,910 | Josh Beckett | Tim Hudson | Josh Beckett | Tim Hudson | | 356 | 279 | 77 |
| 2007-06-20 | @ ATL | 71 | W 11-0 | 45-24 | 1 | 49,585 | Julian Tavarez | Buddy Carlyle | Julian Tavarez | Buddy Carlyle | | 367 | 279 | 88 |
| 2007-06-22 | @ SDN | 72 | W 2-1 | 46-24 | 1 | 44,405 | Daisuke Matsuzaka | Greg Maddux | Daisuke Matsuzaka | Greg Maddux | Jonathan Papelbon | 369 | 280 | 89 |
| 2007-06-23 | @ SDN | 73 | L 1-6 | 46-25 | 1 | 44,457 | Tim Wakefield | Chris Young | Chris Young | Tim Wakefield | | 370 | 286 | 84 |
| 2007-06-24 | @ SDN | 74 | W 4-2 | 47-25 | 1 | 44,449 | Josh Beckett | Jake Peavy | Josh Beckett | Jake Peavy | Jonathan Papelbon | 374 | 288 | 86 |
| 2007-06-25 | @ SEA | 75 | L 4-9 | 47-26 | 1 | 33,830 | Julian Tavarez | Jeff Weaver | Jeff Weaver | Julian Tavarez | | 378 | 297 | 81 |
| 2007-06-26 | @ SEA | 76 | L 7-8 | 47-27 | 1 | 35,045 | Kason Gabbard | Felix Hernandez | Eric O'Flaherty | Javier Lopez | J.J. Putz | 385 | 305 | 80 |
| 2007-06-27 | @ SEA | 77 | L 1-2 | 47-28 | 1 | 43,448 | Daisuke Matsuzaka | Ryan Feierabend | Jason Davis | Joel Pineiro | | 386 | 307 | 79 |
| 2007-06-29 | vs TEX | 78 | W 2-1 | 48-28 | 1 | 36,756 | Tim Wakefield | Jamey Wright | Tim Wakefield | Jamey Wright | Jonathan Papelbon | 388 | 308 | 80 |
| 2007-06-30 | vs TEX | 79 | L 4-5 | 48-29 | 1 | 36,747 | Josh Beckett | Rob Tejeda | Ron Mahay | Josh Beckett | Eric Gagne | 392 | 313 | 79 |
| 2007-07-01 | vs TEX | 80 | L 1-2 | 48-30 | 1 | 36,378 | Julian Tavarez | Kameron Loe | Kameron Loe | Julian Tavarez | Eric Gagne | 393 | 315 | 78 |
| 2007-07-02 | vs TEX | 81 | W 7-3 | 49-30 | 1 | 36,778 | Kason Gabbard | Brandon McCarthy | Kason Gabbard | Brandon McCarthy | | 400 | 318 | 82 |
| 2007-07-03 | vs TBA | 82 | W 4-1 | 50-30 | 1 | 37,005 | Daisuke Matsuzaka | Scott Kazmir | Daisuke Matsuzaka | Scott Kazmir | | 404 | 319 | 85 |
| 2007-07-04 | vs TBA | 83 | W 7-5 | 51-30 | 1 | 36,629 | Tim Wakefield | Edwin Jackson | Tim Wakefield | Edwin Jackson | Jonathan Papelbon | 411 | 324 | 87 |
| 2007-07-05 | vs TBA | 84 | W 15-4 | 52-30 | 1 | 37,044 | Josh Beckett | J.P. Howell | Josh Beckett | J.P. Howell | | 426 | 328 | 98 |
| 2007-07-06 | @ DET | 85 | L 2-9 | 52-31 | 1 | 43,839 | Julian Tavarez | Andrew Miller | Andrew Miller | Julian Tavarez | | 428 | 337 | 91 |
| 2007-07-07 | @ DET | 86 | L 2-3 | 52-32 | 1 | 44,193 | Kason Gabbard | Jeremy Bonderman | Jason Grilli | Jonathan Papelbon | | 430 | 340 | 90 |
| 2007-07-08 | @ DET | 87 | L 5-6 | 52-33 | 1 | 41,943 | Daisuke Matsuzaka | Nate Robertson | Nate Robertson | Daisuke Matsuzaka | Todd Jones | 435 | 346 | 89 |
| 2007-07-12 | vs TOR | 88 | W 7-4 | 53-33 | 1 | 36,887 | Tim Wakefield | Roy Halladay | Tim Wakefield | Roy Halladay | Jonathan Papelbon | 442 | 350 | 92 |
| 2007-07-13 | vs TOR | 89 | L 5-6 | 53-34 | 1 | 36,908 | Julian Tavarez | Shaun Marcum | Shaun Marcum | Kyle Snyder | Jeremy Accardo | 447 | 356 | 91 |
| 2007-07-14 | vs TOR | 90 | W 9-4 | 54-34 | 1 | 36,830 | Daisuke Matsuzaka | Dustin McGowan | Daisuke Matsuzaka | Dustin McGowan | | 456 | 360 | 96 |
| 2007-07-15 | vs TOR | 91 | L 1-2 | 54-35 | 1 | 36,301 | Josh Beckett | Jesse Litsch | Jesse Litsch | Josh Beckett | Jeremy Accardo | 457 | 362 | 95 |
| 2007-07-16 | vs KCA | 92 | W 4-0 | 55-35 | 1 | 37,099 | Kason Gabbard | Brian Bannister | Kason Gabbard | Brian Bannister | | 461 | 362 | 99 |
| 2007-07-17 | vs KCA | 93 | L 3-9 | 55-36 | 1 | 37,001 | Tim Wakefield | Leo Nunez | Jimmy Gobble | Tim Wakefield | | 464 | 371 | 93 |
| 2007-07-18 | vs KCA | 94 | L 5-6 | 55-37 | 1 | 36,681 | Julian Tavarez | Odalis Perez | Odalis Perez | Julian Tavarez | Octavio Dotel | 469 | 377 | 92 |
| 2007-07-19 | vs CHA | 95 | L 2-4 | 55-38 | 1 | 36,913 | Daisuke Matsuzaka | Javier Vazquez | Javier Vazquez | Daisuke Matsuzaka | Bobby Jenks | 471 | 381 | 90 |
| 2007-07-20 | vs CHA | 96 | W 10-3 | 56-38 | 1 | 36,737 | Josh Beckett | Jose Contreras | Josh Beckett | Jose Contreras | | 481 | 384 | 97 |
| 2007-07-21 | vs CHA | 97 | W 11-2 | 57-38 | 1 | 36,283 | Kason Gabbard | John Danks | Kason Gabbard | John Danks | | 492 | 386 | 106 |
| 2007-07-22 | vs CHA | 98 | W 8-5 | 58-38 | 1 | 36,346 | Tim Wakefield | Jon Garland | Tim Wakefield | Jon Garland | Jonathan Papelbon | 500 | 391 | 109 |
| 2007-07-23 | @ CLE | 99 | W 6-2 | 59-38 | 1 | 32,439 | Jon Lester | Jake Westbrook | Jon Lester | Jake Westbrook | Manny Delcarmen | 506 | 393 | 113 |
| 2007-07-24 | @ CLE | 100 | W 1-0 | 60-38 | 1 | 39,339 | Daisuke Matsuzaka | CC Sabathia | Daisuke Matsuzaka | CC Sabathia | Jonathan Papelbon | 507 | 393 | 114 |
| 2007-07-25 | @ CLE | 101 | L 0-1 | 60-39 | 1 | 29,614 | Josh Beckett | Fausto Carmona | Fausto Carmona | Josh Beckett | Joe Borowski | 507 | 394 | 113 |
| 2007-07-26 | @ CLE | 102 | W 14-9 | 61-39 | 1 | 34,286 | Kason Gabbard | Cliff Lee | Julian Tavarez | Cliff Lee | | 521 | 403 | 118 |
| 2007-07-27 | @ TBA | 103 | W 7-1 | 62-39 | 1 | 33,144 | Tim Wakefield | Jason Hammel | Tim Wakefield | Jason Hammel | | 528 | 404 | 124 |
| 2007-07-28 | @ TBA | 104 | W 12-6 | 63-39 | 1 | 36,048 | Jon Lester | James Shields | Kyle Snyder | Brian Stokes | | 540 | 410 | 130 |
| 2007-07-29 | @ TBA | 105 | L 2-5 | 63-40 | 1 | 34,813 | Daisuke Matsuzaka | Scott Kazmir | Gary Glover | Daisuke Matsuzaka | | 542 | 415 | 127 |
| 2007-07-31 | vs BAL | 106 | L 3-5 | 63-41 | 1 | 36,866 | Josh Beckett | Erik Bedard | Erik Bedard | Josh Beckett | Jamie Walker | 545 | 420 | 125 |
| 2007-08-01 | vs BAL | 107 | W 5-4 | 64-41 | 1 | 36,649 | Julian Tavarez | Steve Trachsel | Javier Lopez | John Parrish | Jonathan Papelbon | 550 | 424 | 126 |
| 2007-08-02 | vs BAL | 108 | W 7-4 | 65-41 | 1 | 36,457 | Tim Wakefield | Jeremy Guthrie | Tim Wakefield | Rob Bell | | 557 | 428 | 129 |
| 2007-08-03 | @ SEA | 109 | L 4-7 | 65-42 | 1 | 46,235 | Jon Lester | Horacio Ramirez | Sean Green | Mike Timlin | J.J. Putz | 561 | 435 | 126 |
| 2007-08-04 | @ SEA | 110 | W 4-3 | 66-42 | 1 | 46,313 | Daisuke Matsuzaka | Jarrod Washburn | Daisuke Matsuzaka | Jarrod Washburn | Jonathan Papelbon | 565 | 438 | 127 |
| 2007-08-05 | @ SEA | 111 | W 9-2 | 67-42 | 1 | 46,377 | Josh Beckett | Miguel Batista | Josh Beckett | Miguel Batista | | 574 | 440 | 134 |
| 2007-08-06 | @ ANA | 112 | L 2-4 | 67-43 | 1 | 44,142 | Curt Schilling | Jered Weaver | Justin Speier | Curt Schilling | Francisco Rodriguez | 576 | 444 | 132 |
| 2007-08-07 | @ ANA | 113 | L 4-10 | 67-44 | 1 | 44,177 | Tim Wakefield | Joe Saunders | Joe Saunders | Tim Wakefield | | 580 | 454 | 126 |
| 2007-08-08 | @ ANA | 114 | W 9-6 | 68-44 | 1 | 44,243 | Jon Lester | Dustin Moseley | Hideki Okajima | Justin Speier | Jonathan Papelbon | 589 | 460 | 129 |
| 2007-08-10 | @ BAL | 115 | L 5-6 | 68-45 | 1 | 48,993 | Daisuke Matsuzaka | Erik Bedard | Jim Hoey | Hideki Okajima | | 594 | 466 | 128 |
| 2007-08-11 | @ BAL | 116 | W 6-2 | 69-45 | 1 | 49,242 | Josh Beckett | Garrett Olson | Josh Beckett | Garrett Olson | Jonathan Papelbon | 600 | 468 | 132 |
| 2007-08-12 | @ BAL | 117 | L 3-6 | 69-46 | 1 | 48,551 | Curt Schilling | Steve Trachsel | Chad Bradford | Kyle Snyder | | 603 | 474 | 129 |
| 2007-08-13 | vs TBA | 118 | W 3-0 | 70-46 | 1 | 36,808 | Tim Wakefield | James Shields | Tim Wakefield | James Shields | Jonathan Papelbon | 606 | 474 | 132 |
| 2007-08-14 | vs TBA | 119 | W 2-1 | 71-46 | 1 | 36,837 | Jon Lester | Scott Kazmir | Eric Gagne | Alberto Reyes | | 608 | 475 | 133 |
| 2007-08-15 | vs TBA | 120 | L 5-6 | 71-47 | 1 | 36,413 | Daisuke Matsuzaka | Andy Sonnanstine | Andy Sonnanstine | Daisuke Matsuzaka | Alberto Reyes | 613 | 481 | 132 |
| 2007-08-17 | vs ANA | 121 | W 8-4 | 71-48 | 1 | 36,686 | Clay Buchholz | John Lackey | Clay Buchholz | John Lackey | Jonathan Papelbon | 621 | 485 | 136 |
| 2007-08-17 | vs ANA | 122 | L 5-7 | 71-48 | 1 | 36,538 | Josh Beckett | Ervin Santana | Francisco Rodriguez | Eric Gagne | | 626 | 492 | 134 |
| 2007-08-18 | vs ANA | 123 | W 10-5 | 72-48 | 1 | 36,652 | Curt Schilling | Jered Weaver | Curt Schilling | Jered Weaver | | 636 | 497 | 139 |
| 2007-08-19 | vs ANA | 124 | L 1-3 | 72-49 | 1 | 36,346 | Julian Tavarez | Joe Saunders | Joe Saunders | Julian Tavarez | Francisco Rodriguez | 637 | 500 | 137 |
| 2007-08-20 | @ TBA | 125 | W 6-0 | 73-49 | 1 | 16,843 | Tim Wakefield | Scott Kazmir | Tim Wakefield | Scott Kazmir | | 643 | 500 | 143 |
| 2007-08-21 | @ TBA | 126 | W 8-6 | 74-49 | 1 | 16,393 | Jon Lester | Andy Sonnanstine | Jon Lester | Andy Sonnanstine | Jonathan Papelbon | 651 | 506 | 145 |
| 2007-08-22 | @ TBA | 127 | L 1-2 | 74-50 | 1 | 17,839 | Daisuke Matsuzaka | Edwin Jackson | Edwin Jackson | Daisuke Matsuzaka | Alberto Reyes | 652 | 508 | 144 |
| 2007-08-24 | @ CHA | 128 | W 11-3 | 75-50 | 1 | 30,581 | Josh Beckett | Jon Garland | Josh Beckett | Jon Garland | | 663 | 511 | 152 |
| 2007-08-24 | @ CHA | 129 | W 10-1 | 75-50 | 1 | 37,639 | Curt Schilling | John Danks | Curt Schilling | John Danks | | 673 | 512 | 161 |
| 2007-08-25 | @ CHA | 130 | W 14-2 | 76-50 | 1 | 38,874 | Tim Wakefield | Mark Buehrle | Tim Wakefield | Mark Buehrle | | 687 | 514 | 173 |
| 2007-08-26 | @ CHA | 131 | W 11-1 | 77-50 | 1 | 36,745 | Julian Tavarez | Javier Vazquez | Julian Tavarez | Javier Vazquez | | 698 | 515 | 183 |
| 2007-08-28 | @ NYA | 132 | L 3-5 | 77-51 | 1 | 55,037 | Daisuke Matsuzaka | Andy Pettitte | Andy Pettitte | Daisuke Matsuzaka | Mariano Rivera | 701 | 520 | 181 |
| 2007-08-29 | @ NYA | 133 | L 3-4 | 77-52 | 1 | 54,986 | Josh Beckett | Roger Clemens | Roger Clemens | Josh Beckett | Mariano Rivera | 704 | 524 | 180 |
| 2007-08-30 | @ NYA | 134 | L 0-5 | 77-53 | 1 | 55,067 | Curt Schilling | Chien-Ming Wang | Chien-Ming Wang | Curt Schilling | | 704 | 529 | 175 |
| 2007-08-31 | vs BAL | 135 | L 8-9 | 77-54 | 1 | 36,810 | Julian Tavarez | Radhames Liz | Kurt Birkins | Julian Tavarez | Danys Baez | 712 | 538 | 174 |
| 2007-09-01 | vs BAL | 136 | W 10-0 | 78-54 | 1 | 36,819 | Clay Buchholz | Garrett Olson | Clay Buchholz | Garrett Olson | | 722 | 538 | 184 |
| 2007-09-02 | vs BAL | 137 | W 3-2 | 79-54 | 1 | 36,340 | Jon Lester | Daniel Cabrera | Jon Lester | Daniel Cabrera | Jonathan Papelbon | 725 | 540 | 185 |
| 2007-09-03 | vs TOR | 138 | W 13-10 | 80-54 | 1 | 36,639 | Daisuke Matsuzaka | Jesse Litsch | Daisuke Matsuzaka | Jesse Litsch | Jonathan Papelbon | 738 | 550 | 188 |
| 2007-09-04 | vs TOR | 139 | W 5-3 | 81-54 | 1 | 36,839 | Josh Beckett | Roy Halladay | Josh Beckett | Roy Halladay | Jonathan Papelbon | 743 | 553 | 190 |
| 2007-09-05 | vs TOR | 140 | L 4-6 | 81-55 | 1 | 37,106 | Curt Schilling | Shaun Marcum | Jeremy Accardo | Hideki Okajima | | 747 | 559 | 188 |
| 2007-09-06 | @ BAL | 141 | W 7-6 | 82-55 | 1 | 27,472 | Tim Wakefield | Garrett Olson | Clay Buchholz | Danys Baez | Jonathan Papelbon | 754 | 565 | 189 |
| 2007-09-07 | @ BAL | 142 | W 4-0 | 83-55 | 1 | 34,091 | Jon Lester | Daniel Cabrera | Jon Lester | Daniel Cabrera | | 758 | 565 | 193 |
| 2007-09-08 | @ BAL | 143 | L 5-11 | 83-56 | 1 | 48,043 | Daisuke Matsuzaka | Jon Leicester | Jon Leicester | Daisuke Matsuzaka | | 763 | 576 | 187 |
| 2007-09-09 | @ BAL | 144 | W 3-2 | 84-56 | 1 | 39,234 | Josh Beckett | Jeremy Guthrie | Josh Beckett | Chad Bradford | Jonathan Papelbon | 766 | 578 | 188 |
| 2007-09-10 | vs TBA | 145 | L 0-1 | 84-57 | 1 | 36,907 | Curt Schilling | Scott Kazmir | Scott Kazmir | Curt Schilling | Alberto Reyes | 766 | 579 | 187 |
| 2007-09-11 | vs TBA | 146 | W 16-10 | 85-57 | 1 | 36,640 | Tim Wakefield | Andy Sonnanstine | Bryan Corey | Jon Switzer | | 782 | 589 | 193 |
| 2007-09-12 | vs TBA | 147 | W 5-4 | 86-57 | 1 | 36,931 | Jon Lester | Edwin Jackson | Jonathan Papelbon | Alberto Reyes | | 787 | 593 | 194 |
| 2007-09-14 | vs NYA | 148 | L 7-8 | 86-58 | 1 | 36,590 | Daisuke Matsuzaka | Andy Pettitte | Brian Bruney | Jonathan Papelbon | Mariano Rivera | 794 | 601 | 193 |
| 2007-09-15 | vs NYA | 149 | W 10-1 | 87-58 | 1 | 36,215 | Josh Beckett | Chien-Ming Wang | Josh Beckett | Chien-Ming Wang | | 804 | 602 | 202 |
| 2007-09-16 | vs NYA | 150 | L 3-4 | 87-59 | 1 | 36,533 | Curt Schilling | Roger Clemens | Joba Chamberlain | Curt Schilling | Mariano Rivera | 807 | 606 | 201 |
| 2007-09-17 | @ TOR | 151 | L 1-6 | 87-60 | 1 | 29,316 | Tim Wakefield | Dustin McGowan | Dustin McGowan | Tim Wakefield | | 808 | 612 | 196 |
| 2007-09-18 | @ TOR | 152 | L 3-4 | 87-61 | 1 | 32,290 | Jon Lester | A.J. Burnett | A.J. Burnett | Eric Gagne | Scott Downs | 811 | 616 | 195 |
| 2007-09-19 | @ TOR | 153 | L 1-6 | 87-62 | 1 | 34,927 | Clay Buchholz | Jesse Litsch | Jesse Litsch | Clay Buchholz | Jeremy Accardo | 812 | 622 | 190 |
| 2007-09-21 | @ TBA | 154 | W 8-1 | 88-62 | 1 | 27,369 | Josh Beckett | Scott Kazmir | Josh Beckett | Scott Kazmir | | 820 | 623 | 197 |
| 2007-09-22 | @ TBA | 155 | W 8-6 | 89-62 | 1 | 34,626 | Daisuke Matsuzaka | Andy Sonnanstine | Eric Gagne | Alberto Reyes | Jonathan Papelbon | 828 | 629 | 199 |
| 2007-09-23 | @ TBA | 156 | L 4-5 | 89-63 | 1 | 30,310 | Tim Wakefield | Edwin Jackson | Edwin Jackson | Tim Wakefield | Alberto Reyes | 832 | 634 | 198 |
| 2007-09-25 | vs OAK | 157 | W 7-3 | 90-63 | 1 | 36,708 | Curt Schilling | Chad Gaudin | Curt Schilling | Chad Gaudin | | 839 | 637 | 202 |
| 2007-09-26 | vs OAK | 158 | W 11-6 | 91-63 | 1 | 36,570 | Jon Lester | Joe Blanton | Mike Timlin | Jerry Blevins | | 850 | 643 | 207 |
| 2007-09-27 | vs MIN | 159 | L 4-5 | 91-64 | 1 | 36,743 | Josh Beckett | Boof Bonser | Boof Bonser | Josh Beckett | Joe Nathan | 854 | 648 | 206 |
| 2007-09-28 | vs MIN | 160 | W 5-2 | 92-64 | 1 | 36,843 | Daisuke Matsuzaka | Kevin Slowey | Daisuke Matsuzaka | Kevin Slowey | Jonathan Papelbon | 859 | 650 | 209 |
| 2007-09-29 | vs MIN | 161 | W 6-4 | 93-64 | 1 | 36,619 | Tim Wakefield | Carlos Silva | Tim Wakefield | Nick Blackburn | Hideki Okajima | 865 | 654 | 211 |
| 2007-09-30 | vs MIN | 162 | L 2-3 | 93-65 | 1 | 36,364 | Julian Tavarez | Matt Garza | Matt Garza | Julian Tavarez | Joe Nathan | 867 | 657 | 210 |