| 2007-04-02 | @ DET | 1 | W 5-3 | 1-0 | 2 | 44,297 | Roy Halladay | Jeremy Bonderman | Jason Frasor | Fernando Rodney | B.J. Ryan | 5 | 3 | 2 |
| 2007-04-04 | @ DET | 2 | L 9-10 | 1-1 | 3 | 24,881 | A.J. Burnett | Nate Robertson | Nate Robertson | A.J. Burnett | Todd Jones | 14 | 13 | 1 |
| 2007-04-06 | @ TBA | 3 | L 5-6 | 1-2 | 4 | 38,437 | Gustavo Chacin | James Shields | Jae Kuk Ryu | B.J. Ryan | | 19 | 19 | 0 |
| 2007-04-07 | @ TBA | 4 | W 8-5 | 2-2 | 3 | 18,495 | Tomo Ohka | Casey Fossum | Shaun Marcum | Casey Fossum | B.J. Ryan | 27 | 24 | 3 |
| 2007-04-08 | @ TBA | 5 | W 6-3 | 3-2 | 1 | 12,436 | Roy Halladay | Scott Kazmir | Roy Halladay | Scott Kazmir | Casey Janssen | 33 | 27 | 6 |
| 2007-04-09 | vs KCA | 6 | W 9-1 | 4-2 | 1 | 50,125 | A.J. Burnett | Odalis Perez | A.J. Burnett | Odalis Perez | | 42 | 28 | 14 |
| 2007-04-10 | vs KCA | 7 | L 3-6 | 4-3 | 3 | 22,106 | Josh Towers | Zack Greinke | Zack Greinke | Josh Towers | Joakim Soria | 45 | 34 | 11 |
| 2007-04-11 | vs KCA | 8 | W 7-4 | 5-3 | 1 | 15,218 | Gustavo Chacin | Jorge de la Rosa | Gustavo Chacin | Jorge de la Rosa | B.J. Ryan | 52 | 38 | 14 |
| 2007-04-12 | vs DET | 9 | L 4-5 | 5-4 | 1 | 20,416 | Tomo Ohka | Mike Maroth | Mike Maroth | Tomo Ohka | Joel Zumaya | 56 | 43 | 13 |
| 2007-04-13 | vs DET | 10 | W 2-1 | 6-4 | 1 | 26,268 | Roy Halladay | Jeremy Bonderman | Roy Halladay | Fernando Rodney | | 58 | 44 | 14 |
| 2007-04-14 | vs DET | 11 | L 7-10 | 6-5 | 2 | 28,203 | A.J. Burnett | Chad Durbin | Wil Ledezma | B.J. Ryan | Todd Jones | 65 | 54 | 11 |
| 2007-04-15 | vs DET | 12 | W 2-1 | 7-5 | 2 | 25,983 | Josh Towers | Nate Robertson | Josh Towers | Nate Robertson | Shaun Marcum | 67 | 55 | 12 |
| 2007-04-17 | vs BOS | 13 | W 2-1 | 8-5 | 1 | 42,162 | Gustavo Chacin | Daisuke Matsuzaka | Gustavo Chacin | Daisuke Matsuzaka | Jason Frasor | 69 | 56 | 13 |
| 2007-04-18 | vs BOS | 14 | L 1-4 | 8-6 | 2 | 20,188 | Tomo Ohka | Tim Wakefield | Tim Wakefield | Tomo Ohka | Jonathan Papelbon | 70 | 60 | 10 |
| 2007-04-19 | vs BOS | 15 | L 3-5 | 8-7 | 4 | 33,297 | Roy Halladay | Julian Tavarez | Mike Timlin | Shaun Marcum | Jonathan Papelbon | 73 | 65 | 8 |
| 2007-04-20 | @ BAL | 16 | L 4-5 | 8-8 | 4 | 25,025 | A.J. Burnett | Daniel Cabrera | Chris Ray | Victor Zambrano | | 77 | 70 | 7 |
| 2007-04-21 | @ BAL | 17 | L 2-5 | 8-9 | 4 | 25,898 | Josh Towers | Adam Loewen | Adam Loewen | Josh Towers | Chris Ray | 79 | 75 | 4 |
| 2007-04-22 | @ BAL | 18 | L 3-7 | 8-10 | 4 | 27,285 | Gustavo Chacin | Steve Trachsel | Steve Trachsel | Gustavo Chacin | | 82 | 82 | 0 |
| 2007-04-23 | @ BOS | 19 | W 7-3 | 9-10 | 3 | 36,669 | Tomo Ohka | Tim Wakefield | Tomo Ohka | Tim Wakefield | Jason Frasor | 89 | 85 | 4 |
| 2007-04-24 | @ BOS | 20 | W 10-3 | 10-10 | 3 | 37,161 | Roy Halladay | Julian Tavarez | Roy Halladay | Julian Tavarez | | 99 | 88 | 11 |
| 2007-04-26 | @ NYA | 21 | W 6-0 | 11-10 | 2 | 45,118 | A.J. Burnett | Phil Hughes | A.J. Burnett | Phil Hughes | | 105 | 88 | 17 |
| 2007-04-27 | vs TEX | 22 | L 3-5 | 11-11 | 2 | 24,795 | Josh Towers | Rob Tejeda | Rob Tejeda | Josh Towers | Akinori Otsuka | 108 | 93 | 15 |
| 2007-04-28 | vs TEX | 23 | L 8-9 | 11-12 | 3 | 24,119 | Gustavo Chacin | Kevin Millwood | Akinori Otsuka | Brian Tallet | Joaquin Benoit | 116 | 102 | 14 |
| 2007-04-29 | vs TEX | 24 | W 7-3 | 12-12 | 2 | 27,516 | Tomo Ohka | Brandon McCarthy | Tomo Ohka | Brandon McCarthy | | 123 | 105 | 18 |
| 2007-04-30 | vs TEX | 25 | W 6-1 | 13-12 | 2 | 19,041 | Roy Halladay | Vicente Padilla | Roy Halladay | Vicente Padilla | | 129 | 106 | 23 |
| 2007-05-01 | @ CLE | 26 | L 4-12 | 13-13 | 2 | 13,389 | A.J. Burnett | CC Sabathia | CC Sabathia | A.J. Burnett | | 133 | 118 | 15 |
| 2007-05-02 | @ CLE | 27 | L 6-7 | 13-14 | 2 | 14,163 | Victor Zambrano | Jake Westbrook | Tom Mastny | Shaun Marcum | | 139 | 125 | 14 |
| 2007-05-03 | @ CLE | 28 | L 5-6 | 13-15 | 3 | 16,284 | Dustin McGowan | Cliff Lee | Aaron Fultz | Jason Frasor | Joe Borowski | 144 | 131 | 13 |
| 2007-05-04 | @ TEX | 29 | L 1-7 | 13-16 | 4 | 24,342 | Tomo Ohka | Brandon McCarthy | Brandon McCarthy | Tomo Ohka | Willie Eyre | 145 | 138 | 7 |
| 2007-05-05 | @ TEX | 30 | L 4-11 | 13-17 | 5 | 27,421 | Roy Halladay | Vicente Padilla | Vicente Padilla | Roy Halladay | | 149 | 149 | 0 |
| 2007-05-06 | @ TEX | 31 | L 2-3 | 13-18 | 5 | 19,103 | A.J. Burnett | Kameron Loe | Joaquin Benoit | A.J. Burnett | Akinori Otsuka | 151 | 152 | -1 |
| 2007-05-08 | vs BOS | 32 | L 2-9 | 13-19 | 5 | 41,203 | Victor Zambrano | Josh Beckett | Josh Beckett | Victor Zambrano | | 153 | 161 | -8 |
| 2007-05-09 | vs BOS | 33 | L 3-9 | 13-20 | 5 | 21,784 | Tomo Ohka | Daisuke Matsuzaka | Daisuke Matsuzaka | Tomo Ohka | | 156 | 170 | -14 |
| 2007-05-10 | vs BOS | 34 | L 0-8 | 13-21 | 5 | 22,290 | Roy Halladay | Tim Wakefield | Tim Wakefield | Roy Halladay | | 156 | 178 | -22 |
| 2007-05-11 | vs TBA | 35 | W 5-1 | 14-21 | 5 | 20,542 | A.J. Burnett | Scott Kazmir | A.J. Burnett | Scott Kazmir | | 161 | 179 | -18 |
| 2007-05-12 | vs TBA | 36 | W 5-4 | 15-21 | 4 | 23,208 | Dustin McGowan | Edwin Jackson | Scott Downs | Brian Stokes | Jeremy Accardo | 166 | 183 | -17 |
| 2007-05-13 | vs TBA | 37 | L 1-2 | 15-22 | 5 | 25,453 | Shaun Marcum | Jae Weong Seo | Jae Weong Seo | Jason Frasor | Alberto Reyes | 167 | 185 | -18 |
| 2007-05-14 | vs BAL | 38 | W 5-3 | 16-22 | 4 | 19,819 | Tomo Ohka | Erik Bedard | Casey Janssen | Danys Baez | Jeremy Accardo | 172 | 188 | -16 |
| 2007-05-15 | vs BAL | 39 | W 2-1 | 17-22 | 4 | 30,958 | Jesse Litsch | Daniel Cabrera | Jesse Litsch | Daniel Cabrera | Jeremy Accardo | 174 | 189 | -15 |
| 2007-05-16 | vs BAL | 40 | W 2-1 | 18-22 | 3 | 24,339 | A.J. Burnett | Brian Burres | A.J. Burnett | Brian Burres | | 176 | 190 | -14 |
| 2007-05-18 | @ PHI | 41 | L 3-5 | 18-23 | 4 | 34,723 | Dustin McGowan | Jon Lieber | Jon Lieber | Dustin McGowan | Brett Myers | 179 | 195 | -16 |
| 2007-05-19 | @ PHI | 42 | W 13-2 | 19-23 | 3 | 32,004 | Shaun Marcum | Jamie Moyer | Shaun Marcum | Jamie Moyer | | 192 | 197 | -5 |
| 2007-05-20 | @ PHI | 43 | L 3-5 | 19-24 | 3 | 39,030 | Jesse Litsch | Adam Eaton | Adam Eaton | Jesse Litsch | Brett Myers | 195 | 202 | -7 |
| 2007-05-22 | @ BAL | 44 | W 6-4 | 20-24 | 2 | 17,852 | A.J. Burnett | Daniel Cabrera | A.J. Burnett | Daniel Cabrera | Jeremy Accardo | 201 | 206 | -5 |
| 2007-05-23 | @ BAL | 45 | L 2-5 | 20-25 | 3 | 16,938 | Dustin McGowan | Steve Trachsel | Steve Trachsel | Dustin McGowan | Chris Ray | 203 | 211 | -8 |
| 2007-05-24 | @ BAL | 46 | W 5-4 | 21-25 | 2 | 15,182 | Shaun Marcum | Jeremy Guthrie | Casey Janssen | Danys Baez | Jeremy Accardo | 208 | 215 | -7 |
| 2007-05-25 | @ MIN | 47 | L 3-4 | 21-26 | 2 | 26,781 | Jesse Litsch | Scott Baker | Matt Guerrier | Scott Downs | Joe Nathan | 211 | 219 | -8 |
| 2007-05-26 | @ MIN | 48 | W 9-8 | 22-26 | 2 | 31,434 | Tomo Ohka | Ramon Ortiz | Brian Tallet | Matt Guerrier | | 220 | 227 | -7 |
| 2007-05-27 | @ MIN | 49 | L 2-4 | 22-27 | 3 | 25,781 | A.J. Burnett | Carlos Silva | Carlos Silva | A.J. Burnett | Joe Nathan | 222 | 231 | -9 |
| 2007-05-28 | vs NYA | 50 | W 7-2 | 23-27 | 3 | 28,791 | Dustin McGowan | Matt DeSalvo | Dustin McGowan | Matt DeSalvo | | 229 | 233 | -4 |
| 2007-05-29 | vs NYA | 51 | W 3-2 | 24-27 | 3 | 30,116 | Shaun Marcum | Andy Pettitte | Jeremy Accardo | Andy Pettitte | | 232 | 235 | -3 |
| 2007-05-30 | vs NYA | 52 | L 5-10 | 24-28 | 3 | 29,187 | Jesse Litsch | Tyler Clippard | Tyler Clippard | Jesse Litsch | Mariano Rivera | 237 | 245 | -8 |
| 2007-05-31 | vs CHA | 53 | W 2-0 | 25-28 | 3 | 22,436 | Roy Halladay | Mark Buehrle | Roy Halladay | Mark Buehrle | Jeremy Accardo | 239 | 245 | -6 |
| 2007-06-01 | vs CHA | 54 | L 0-3 | 25-29 | 3 | 20,051 | A.J. Burnett | Javier Vazquez | Javier Vazquez | A.J. Burnett | Bobby Jenks | 239 | 248 | -9 |
| 2007-06-02 | vs CHA | 55 | W 9-3 | 26-29 | 3 | 25,691 | Dustin McGowan | Jose Contreras | Dustin McGowan | Mike MacDougal | Casey Janssen | 248 | 251 | -3 |
| 2007-06-03 | vs CHA | 56 | W 4-3 | 27-29 | 2 | 30,886 | Shaun Marcum | John Danks | Brian Tallet | Nick Masset | Jeremy Accardo | 252 | 254 | -2 |
| 2007-06-05 | vs TBA | 57 | W 12-11 | 28-29 | 2 | 19,063 | Roy Halladay | Andy Sonnanstine | Josh Towers | Casey Fossum | | 264 | 265 | -1 |
| 2007-06-06 | vs TBA | 58 | L 2-6 | 28-30 | 2 | 16,663 | Tomo Ohka | Scott Kazmir | Scott Kazmir | Tomo Ohka | | 266 | 271 | -5 |
| 2007-06-07 | vs TBA | 59 | L 3-5 | 28-31 | 2 | 37,105 | A.J. Burnett | Edwin Jackson | Gary Glover | Jeremy Accardo | Alberto Reyes | 269 | 276 | -7 |
| 2007-06-08 | @ LAN | 60 | L 3-4 | 28-32 | 3 | 52,173 | Dustin McGowan | Brad Penny | Rudy Seanez | Jeremy Accardo | | 272 | 280 | -8 |
| 2007-06-09 | @ LAN | 61 | W 1-0 | 29-32 | 2 | 51,057 | Shaun Marcum | Derek Lowe | Shaun Marcum | Derek Lowe | Casey Janssen | 273 | 280 | -7 |
| 2007-06-10 | @ LAN | 62 | W 11-5 | 30-32 | 2 | 50,183 | Roy Halladay | Jason Schmidt | Roy Halladay | Jason Schmidt | | 284 | 285 | -1 |
| 2007-06-11 | @ SFN | 63 | L 3-4 | 30-33 | 2 | 38,030 | Josh Towers | Matt Morris | Matt Morris | Josh Towers | | 287 | 289 | -2 |
| 2007-06-12 | @ SFN | 64 | L 2-3 | 30-34 | 3 | 37,574 | A.J. Burnett | Noah Lowry | Noah Lowry | A.J. Burnett | Brad Hennessey | 289 | 292 | -3 |
| 2007-06-13 | @ SFN | 65 | W 7-4 | 31-34 | 3 | 40,086 | Dustin McGowan | Tim Lincecum | Dustin McGowan | Tim Lincecum | Jeremy Accardo | 296 | 296 | 0 |
| 2007-06-15 | vs WAS | 66 | W 7-2 | 32-34 | 3 | 22,042 | Roy Halladay | Michael Bacsik | Roy Halladay | Michael Bacsik | | 303 | 298 | 5 |
| 2007-06-16 | vs WAS | 67 | W 7-3 | 33-34 | 3 | 26,342 | Shaun Marcum | Levale Speigner | Shaun Marcum | Levale Speigner | | 310 | 301 | 9 |
| 2007-06-17 | vs WAS | 68 | L 2-4 | 33-35 | 3 | 28,867 | Josh Towers | Micah Bowie | Micah Bowie | Josh Towers | Chad Cordero | 312 | 305 | 7 |
| 2007-06-19 | vs LAN | 69 | L 1-10 | 33-36 | 3 | 22,763 | Dustin McGowan | Brad Penny | Brad Penny | Dustin McGowan | | 313 | 315 | -2 |
| 2007-06-20 | vs LAN | 70 | W 12-1 | 34-36 | 3 | 24,413 | Roy Halladay | Hong-Chih Kuo | Roy Halladay | Hong-Chih Kuo | | 325 | 316 | 9 |
| 2007-06-21 | vs LAN | 71 | L 4-8 | 34-37 | 3 | 25,265 | Shaun Marcum | Chad Billingsley | Rudy Seanez | Casey Janssen | | 329 | 324 | 5 |
| 2007-06-22 | vs COL | 72 | W 9-8 | 35-37 | 3 | 27,369 | Josh Towers | Jason Hirsh | Brian Wolfe | Brian Fuentes | | 338 | 332 | 6 |
| 2007-06-23 | vs COL | 73 | W 11-6 | 36-37 | 2 | 32,482 | Ty Taubenheim | Aaron Cook | Brian Wolfe | Aaron Cook | | 349 | 338 | 11 |
| 2007-06-24 | vs COL | 74 | W 5-0 | 37-37 | 2 | 33,910 | Dustin McGowan | Josh Fogg | Dustin McGowan | Josh Fogg | | 354 | 338 | 16 |
| 2007-06-25 | @ MIN | 75 | W 8-5 | 38-37 | 2 | 24,240 | Roy Halladay | Kevin Slowey | Roy Halladay | Matt Guerrier | Jeremy Accardo | 362 | 343 | 19 |
| 2007-06-26 | @ MIN | 76 | L 1-2 | 38-38 | 2 | 27,000 | Shaun Marcum | Scott Baker | Juan Rincon | Brian Tallet | | 363 | 345 | 18 |
| 2007-06-27 | @ MIN | 77 | W 5-4 | 39-38 | 2 | 30,959 | Josh Towers | Boof Bonser | Josh Towers | Boof Bonser | Jeremy Accardo | 368 | 349 | 19 |
| 2007-06-28 | @ MIN | 78 | L 5-8 | 39-39 | 2 | 31,038 | A.J. Burnett | Carlos Silva | Carlos Silva | Jason Frasor | Joe Nathan | 373 | 357 | 16 |
| 2007-06-29 | @ SEA | 79 | L 3-5 | 39-40 | 2 | 41,862 | Dustin McGowan | Jarrod Washburn | Jarrod Washburn | Dustin McGowan | J.J. Putz | 376 | 362 | 14 |
| 2007-06-30 | @ SEA | 80 | L 3-8 | 39-41 | 2 | 36,102 | Roy Halladay | Miguel Batista | Miguel Batista | Roy Halladay | | 379 | 370 | 9 |
| 2007-07-01 | @ SEA | 81 | L 1-2 | 39-42 | 2 | 38,778 | Shaun Marcum | Jeff Weaver | J.J. Putz | Jeremy Accardo | | 380 | 372 | 8 |
| 2007-07-02 | @ OAK | 82 | W 11-7 | 40-42 | 2 | 13,281 | Josh Towers | Lenny DiNardo | Josh Towers | Lenny DiNardo | | 391 | 379 | 12 |
| 2007-07-03 | @ OAK | 83 | L 1-3 | 40-43 | 2 | 35,077 | Jesse Litsch | Joe Blanton | Joe Blanton | Jesse Litsch | | 392 | 382 | 10 |
| 2007-07-04 | @ OAK | 84 | W 10-3 | 41-43 | 2 | 26,566 | Dustin McGowan | Joe Kennedy | Dustin McGowan | Joe Kennedy | | 402 | 385 | 17 |
| 2007-07-06 | vs CLE | 85 | W 8-6 | 42-43 | 2 | 28,526 | Roy Halladay | Cliff Lee | Roy Halladay | Cliff Lee | Jeremy Accardo | 410 | 391 | 19 |
| 2007-07-07 | vs CLE | 86 | L 4-9 | 42-44 | 2 | 25,744 | Shaun Marcum | Fausto Carmona | Fausto Carmona | Shaun Marcum | | 414 | 400 | 14 |
| 2007-07-08 | vs CLE | 87 | W 1-0 | 43-44 | 2 | 28,239 | Josh Towers | Paul Byrd | Jeremy Accardo | Paul Byrd | | 415 | 400 | 15 |
| 2007-07-12 | @ BOS | 88 | L 4-7 | 43-45 | 3 | 36,887 | Roy Halladay | Tim Wakefield | Tim Wakefield | Roy Halladay | Jonathan Papelbon | 419 | 407 | 12 |
| 2007-07-13 | @ BOS | 89 | W 6-5 | 44-45 | 2 | 36,908 | Shaun Marcum | Julian Tavarez | Shaun Marcum | Kyle Snyder | Jeremy Accardo | 425 | 412 | 13 |
| 2007-07-14 | @ BOS | 90 | L 4-9 | 44-46 | 3 | 36,830 | Dustin McGowan | Daisuke Matsuzaka | Daisuke Matsuzaka | Dustin McGowan | | 429 | 421 | 8 |
| 2007-07-15 | @ BOS | 91 | W 2-1 | 45-46 | 3 | 36,301 | Jesse Litsch | Josh Beckett | Jesse Litsch | Josh Beckett | Jeremy Accardo | 431 | 422 | 9 |
| 2007-07-16 | @ NYA | 92 | L 4-6 | 45-47 | 3 | 52,993 | Josh Towers | Kei Igawa | Scott Proctor | Josh Towers | Mariano Rivera | 435 | 428 | 7 |
| 2007-07-17 | @ NYA | 93 | L 2-3 | 45-48 | 3 | 51,961 | Roy Halladay | Andy Pettitte | Luis Vizcaino | Casey Janssen | | 437 | 431 | 6 |
| 2007-07-18 | @ NYA | 94 | L 1-6 | 45-49 | 3 | 52,147 | Shaun Marcum | Roger Clemens | Mike Myers | Shaun Marcum | Mariano Rivera | 438 | 437 | 1 |
| 2007-07-19 | @ NYA | 95 | W 3-2 | 46-49 | 3 | 53,857 | Dustin McGowan | Chien-Ming Wang | Dustin McGowan | Chien-Ming Wang | Jeremy Accardo | 441 | 439 | 2 |
| 2007-07-20 | vs SEA | 96 | L 2-4 | 46-50 | 3 | 27,079 | Jesse Litsch | Miguel Batista | Miguel Batista | Jesse Litsch | J.J. Putz | 443 | 443 | 0 |
| 2007-07-21 | vs SEA | 97 | W 1-0 | 47-50 | 3 | 28,921 | Josh Towers | Jeff Weaver | Josh Towers | Jeff Weaver | Jeremy Accardo | 444 | 443 | 1 |
| 2007-07-22 | vs SEA | 98 | W 8-0 | 48-50 | 3 | 29,083 | Roy Halladay | Felix Hernandez | Roy Halladay | Felix Hernandez | | 452 | 443 | 9 |
| 2007-07-23 | vs MIN | 99 | W 6-4 | 49-50 | 3 | 26,091 | Shaun Marcum | Johan Santana | Shaun Marcum | Johan Santana | Jeremy Accardo | 458 | 447 | 11 |
| 2007-07-24 | vs MIN | 100 | W 7-0 | 50-50 | 3 | 30,669 | Dustin McGowan | Scott Baker | Dustin McGowan | Scott Baker | | 465 | 447 | 18 |
| 2007-07-25 | vs MIN | 101 | W 13-1 | 51-50 | 3 | 37,342 | Jesse Litsch | Carlos Silva | Jesse Litsch | Carlos Silva | | 478 | 448 | 30 |
| 2007-07-27 | @ CHA | 102 | L 3-4 | 51-51 | 3 | 34,590 | Josh Towers | Jon Garland | Jon Garland | Josh Towers | Bobby Jenks | 481 | 452 | 29 |
| 2007-07-28 | @ CHA | 103 | L 0-2 | 51-52 | 3 | 37,744 | Roy Halladay | Mark Buehrle | Mark Buehrle | Roy Halladay | Bobby Jenks | 481 | 454 | 27 |
| 2007-07-29 | @ CHA | 104 | W 4-1 | 52-52 | 3 | 36,571 | Shaun Marcum | Javier Vazquez | Shaun Marcum | Javier Vazquez | Jeremy Accardo | 485 | 455 | 30 |
| 2007-07-30 | @ TBA | 105 | L 4-5 | 52-53 | 3 | 8,807 | Dustin McGowan | Andy Sonnanstine | Scott Dohmann | Brian Wolfe | | 489 | 460 | 29 |
| 2007-07-31 | @ TBA | 106 | W 2-0 | 53-53 | 3 | 10,569 | Jesse Litsch | Edwin Jackson | Jesse Litsch | Edwin Jackson | Jeremy Accardo | 491 | 460 | 31 |
| 2007-08-01 | @ TBA | 107 | L 2-6 | 53-54 | 3 | 10,109 | Josh Towers | Jason Hammel | Gary Glover | Josh Towers | | 493 | 466 | 27 |
| 2007-08-03 | vs TEX | 108 | W 6-4 | 54-54 | 3 | 23,777 | Roy Halladay | Kevin Millwood | Roy Halladay | Jamey Wright | Jeremy Accardo | 499 | 470 | 29 |
| 2007-08-04 | vs TEX | 109 | W 9-5 | 55-54 | 3 | 25,231 | Shaun Marcum | Willie Eyre | Shaun Marcum | Willie Eyre | | 508 | 475 | 33 |
| 2007-08-05 | vs TEX | 110 | W 4-1 | 56-54 | 3 | 29,593 | Dustin McGowan | Brandon McCarthy | Dustin McGowan | Brandon McCarthy | Jeremy Accardo | 512 | 476 | 36 |
| 2007-08-06 | vs NYA | 111 | L 4-5 | 56-55 | 3 | 42,714 | Jesse Litsch | Andy Pettitte | Andy Pettitte | Scott Downs | Mariano Rivera | 516 | 481 | 35 |
| 2007-08-07 | vs NYA | 112 | L 2-9 | 56-56 | 3 | 38,078 | Josh Towers | Roger Clemens | Roger Clemens | Josh Towers | | 518 | 490 | 28 |
| 2007-08-08 | vs NYA | 113 | W 15-4 | 57-56 | 3 | 40,811 | Roy Halladay | Chien-Ming Wang | Roy Halladay | Chien-Ming Wang | | 533 | 494 | 39 |
| 2007-08-10 | @ KCA | 114 | W 2-1 | 58-56 | 3 | 21,276 | Shaun Marcum | Gil Meche | Shaun Marcum | Gil Meche | Jeremy Accardo | 535 | 495 | 40 |
| 2007-08-11 | @ KCA | 115 | L 1-4 | 58-57 | 3 | 25,934 | Dustin McGowan | Leo Nunez | Leo Nunez | Dustin McGowan | Joakim Soria | 536 | 499 | 37 |
| 2007-08-12 | @ KCA | 116 | W 4-1 | 59-57 | 3 | 18,381 | A.J. Burnett | Brian Bannister | A.J. Burnett | Brian Bannister | Jeremy Accardo | 540 | 500 | 40 |
| 2007-08-13 | @ KCA | 117 | L 2-6 | 59-58 | 3 | 14,845 | Jesse Litsch | Odalis Perez | Odalis Perez | Jesse Litsch | | 542 | 506 | 36 |
| 2007-08-14 | vs ANA | 118 | W 4-1 | 60-58 | 3 | 31,978 | Roy Halladay | Joe Saunders | Roy Halladay | Joe Saunders | | 546 | 507 | 39 |
| 2007-08-15 | vs ANA | 119 | W 2-1 | 61-58 | 3 | 30,353 | Shaun Marcum | Dustin Moseley | Shaun Marcum | Dustin Moseley | Jeremy Accardo | 548 | 508 | 40 |
| 2007-08-16 | vs ANA | 120 | L 3-4 | 61-59 | 3 | 27,861 | Dustin McGowan | Kelvim Escobar | Kelvim Escobar | Dustin McGowan | Francisco Rodriguez | 551 | 512 | 39 |
| 2007-08-17 | vs BAL | 121 | W 5-2 | 62-59 | 3 | 25,524 | A.J. Burnett | Garrett Olson | A.J. Burnett | Garrett Olson | Jeremy Accardo | 556 | 514 | 42 |
| 2007-08-18 | vs BAL | 122 | L 3-5 | 62-60 | 3 | 33,387 | Jesse Litsch | Steve Trachsel | Steve Trachsel | Jesse Litsch | Danys Baez | 559 | 519 | 40 |
| 2007-08-19 | vs BAL | 123 | W 3-2 | 63-60 | 3 | 38,132 | Roy Halladay | Jeremy Guthrie | Scott Downs | Chad Bradford | | 562 | 521 | 41 |
| 2007-08-20 | vs OAK | 124 | L 4-6 | 63-61 | 3 | 27,193 | Shaun Marcum | Joe Blanton | Joe Blanton | Shaun Marcum | Huston Street | 566 | 527 | 39 |
| 2007-08-21 | vs OAK | 125 | L 4-6 | 63-62 | 3 | 32,639 | Dustin McGowan | Dan Haren | Dan Haren | Brian Tallet | Huston Street | 570 | 533 | 37 |
| 2007-08-22 | vs OAK | 126 | L 1-4 | 63-63 | 3 | 31,145 | A.J. Burnett | Esteban Loaiza | Esteban Loaiza | A.J. Burnett | Alan Embree | 571 | 537 | 34 |
| 2007-08-23 | @ ANA | 127 | W 5-4 | 64-63 | 3 | 41,009 | Jesse Litsch | Ervin Santana | Jesse Litsch | Ervin Santana | Jeremy Accardo | 576 | 541 | 35 |
| 2007-08-24 | @ ANA | 128 | L 0-3 | 64-64 | 3 | 41,131 | Roy Halladay | Jered Weaver | Jered Weaver | Roy Halladay | Francisco Rodriguez | 576 | 544 | 32 |
| 2007-08-25 | @ ANA | 129 | W 9-2 | 65-64 | 3 | 41,631 | Shaun Marcum | Joe Saunders | Shaun Marcum | Joe Saunders | | 585 | 546 | 39 |
| 2007-08-26 | @ ANA | 130 | L 1-3 | 65-65 | 3 | 40,565 | Dustin McGowan | Kelvim Escobar | Kelvim Escobar | Dustin McGowan | Francisco Rodriguez | 586 | 549 | 37 |
| 2007-08-27 | @ OAK | 131 | W 6-2 | 66-65 | 3 | 18,092 | A.J. Burnett | Esteban Loaiza | Jeremy Accardo | Alan Embree | | 592 | 551 | 41 |
| 2007-08-28 | @ OAK | 132 | W 5-4 | 67-65 | 3 | 20,542 | Jesse Litsch | Chad Gaudin | Brian Wolfe | Andrew Brown | Casey Janssen | 597 | 555 | 42 |
| 2007-08-29 | @ OAK | 133 | L 4-5 | 67-66 | 3 | 16,015 | Roy Halladay | Lenny DiNardo | Ruddy Lugo | Jason Frasor | | 601 | 560 | 41 |
| 2007-08-31 | vs SEA | 134 | W 7-5 | 68-66 | 3 | 34,518 | Shaun Marcum | Jarrod Washburn | Shaun Marcum | Jarrod Washburn | Jeremy Accardo | 608 | 565 | 43 |
| 2007-09-01 | vs SEA | 135 | W 2-1 | 69-66 | 3 | 30,672 | Dustin McGowan | Miguel Batista | Dustin McGowan | Sean Green | Jeremy Accardo | 610 | 566 | 44 |
| 2007-09-02 | vs SEA | 136 | W 6-4 | 70-66 | 3 | 32,166 | A.J. Burnett | Jeff Weaver | A.J. Burnett | Jeff Weaver | Casey Janssen | 616 | 570 | 46 |
| 2007-09-03 | @ BOS | 137 | L 10-13 | 70-67 | 3 | 36,639 | Jesse Litsch | Daisuke Matsuzaka | Daisuke Matsuzaka | Jesse Litsch | Jonathan Papelbon | 626 | 583 | 43 |
| 2007-09-04 | @ BOS | 138 | L 3-5 | 70-68 | 3 | 36,839 | Roy Halladay | Josh Beckett | Josh Beckett | Roy Halladay | Jonathan Papelbon | 629 | 588 | 41 |
| 2007-09-05 | @ BOS | 139 | W 6-4 | 71-68 | 3 | 37,106 | Shaun Marcum | Curt Schilling | Jeremy Accardo | Hideki Okajima | | 635 | 592 | 43 |
| 2007-09-07 | @ TBA | 140 | W 7-2 | 72-68 | 3 | 18,617 | Dustin McGowan | Edwin Jackson | Dustin McGowan | Edwin Jackson | | 642 | 594 | 48 |
| 2007-09-08 | @ TBA | 141 | L 4-5 | 72-69 | 3 | 19,822 | A.J. Burnett | Jason Hammel | Alberto Reyes | Jeremy Accardo | | 646 | 599 | 47 |
| 2007-09-09 | @ TBA | 142 | L 2-3 | 72-70 | 3 | 20,556 | Jesse Litsch | James Shields | James Shields | Jesse Litsch | Alberto Reyes | 648 | 602 | 46 |
| 2007-09-10 | @ DET | 143 | L 4-5 | 72-71 | 3 | 35,689 | Roy Halladay | Kenny Rogers | Yorman Bazardo | Casey Janssen | | 652 | 607 | 45 |
| 2007-09-11 | vs NYA | 144 | L 2-9 | 72-72 | 3 | 30,472 | Shaun Marcum | Phil Hughes | Phil Hughes | Shaun Marcum | | 654 | 616 | 38 |
| 2007-09-12 | vs NYA | 145 | L 1-4 | 72-73 | 3 | 27,082 | Dustin McGowan | Mike Mussina | Mike Mussina | Dustin McGowan | Mariano Rivera | 655 | 620 | 35 |
| 2007-09-13 | vs NYA | 146 | W 2-1 | 73-73 | 3 | 32,632 | A.J. Burnett | Ian Kennedy | Scott Downs | Chris Britton | | 657 | 621 | 36 |
| 2007-09-14 | vs BAL | 147 | L 2-6 | 73-74 | 3 | 31,106 | Jesse Litsch | Brian Burres | Brian Burres | Jesse Litsch | | 659 | 627 | 32 |
| 2007-09-15 | vs BAL | 148 | W 8-3 | 74-74 | 3 | 37,441 | Roy Halladay | Kurt Birkins | Roy Halladay | Kurt Birkins | | 667 | 630 | 37 |
| 2007-09-16 | vs BAL | 149 | L 6-8 | 74-75 | 3 | 38,934 | Shaun Marcum | Victor Santos | Rob Bell | Jason Frasor | Fernando Cabrera | 673 | 638 | 35 |
| 2007-09-17 | vs BOS | 150 | W 6-1 | 75-75 | 3 | 29,316 | Dustin McGowan | Tim Wakefield | Dustin McGowan | Tim Wakefield | | 679 | 639 | 40 |
| 2007-09-18 | vs BOS | 151 | W 4-3 | 76-75 | 3 | 32,290 | A.J. Burnett | Jon Lester | A.J. Burnett | Eric Gagne | Scott Downs | 683 | 642 | 41 |
| 2007-09-19 | vs BOS | 152 | W 6-1 | 77-75 | 3 | 34,927 | Jesse Litsch | Clay Buchholz | Jesse Litsch | Clay Buchholz | Jeremy Accardo | 689 | 643 | 46 |
| 2007-09-21 | @ NYA | 153 | W 5-4 | 78-75 | 3 | 54,151 | Roy Halladay | Chien-Ming Wang | Joe Kennedy | Brian Bruney | Jason Frasor | 694 | 647 | 47 |
| 2007-09-22 | @ NYA | 154 | L 11-12 | 78-76 | 3 | 54,887 | Shaun Marcum | Phil Hughes | Jeff Karstens | Josh Towers | | 705 | 659 | 46 |
| 2007-09-23 | @ NYA | 155 | L 5-7 | 78-77 | 3 | 54,983 | Dustin McGowan | Mike Mussina | Mike Mussina | Dustin McGowan | Joba Chamberlain | 710 | 666 | 44 |
| 2007-09-24 | @ NYA | 156 | W 4-1 | 79-77 | 3 | 53,281 | Jesse Litsch | Andy Pettitte | Jesse Litsch | Andy Pettitte | Casey Janssen | 714 | 667 | 47 |
| 2007-09-25 | @ BAL | 157 | W 11-4 | 80-77 | 3 | 15,867 | A.J. Burnett | Brian Burres | A.J. Burnett | Brian Burres | | 725 | 671 | 54 |
| 2007-09-26 | @ BAL | 158 | W 8-5 | 81-77 | 3 | 15,424 | Roy Halladay | Victor Zambrano | Roy Halladay | Victor Zambrano | Jeremy Accardo | 733 | 676 | 57 |
| 2007-09-27 | @ BAL | 159 | L 5-8 | 81-78 | 3 | 15,817 | Josh Banks | Jeremy Guthrie | Jim Hoey | Brian Tallet | Jamie Walker | 738 | 684 | 54 |
| 2007-09-28 | vs TBA | 160 | W 5-4 | 82-78 | 3 | 34,670 | Dustin McGowan | Andy Sonnanstine | Dustin McGowan | Andy Sonnanstine | Jeremy Accardo | 743 | 688 | 55 |
| 2007-09-29 | vs TBA | 161 | W 5-3 | 83-78 | 3 | 37,681 | Jesse Litsch | Edwin Jackson | Scott Downs | Dan Wheeler | | 748 | 691 | 57 |
| 2007-09-30 | vs TBA | 162 | L 5-8 | 83-79 | 3 | 44,156 | A.J. Burnett | Jason Hammel | Jason Hammel | A.J. Burnett | Alberto Reyes | 753 | 699 | 54 |