| 2007-04-02 | @ NYA | 1 | L 5-9 | 0-1 | 5 | 55,035 | Scott Kazmir | Carl Pavano | Luis Vizcaino | Brian Stokes | | 5 | 9 | -4 |
| 2007-04-05 | @ NYA | 2 | W 7-6 | 1-1 | 3 | 52,096 | Jae Weong Seo | Andy Pettitte | Ruddy Lugo | Luis Vizcaino | Alberto Reyes | 12 | 15 | -3 |
| 2007-04-06 | vs TOR | 3 | W 6-5 | 2-1 | 1 | 38,437 | James Shields | Gustavo Chacin | Jae Kuk Ryu | B.J. Ryan | | 18 | 20 | -2 |
| 2007-04-07 | vs TOR | 4 | L 5-8 | 2-2 | 2 | 18,495 | Casey Fossum | Tomo Ohka | Shaun Marcum | Casey Fossum | B.J. Ryan | 23 | 28 | -5 |
| 2007-04-08 | vs TOR | 5 | L 3-6 | 2-3 | 4 | 12,436 | Scott Kazmir | Roy Halladay | Roy Halladay | Scott Kazmir | Casey Janssen | 26 | 34 | -8 |
| 2007-04-09 | @ TEX | 6 | L 4-8 | 2-4 | 5 | 21,547 | Edwin Jackson | Brandon McCarthy | Brandon McCarthy | Edwin Jackson | | 30 | 42 | -12 |
| 2007-04-10 | @ TEX | 7 | L 9-12 | 2-5 | 5 | 23,897 | Jae Weong Seo | Jamey Wright | Scott Feldman | Jae Weong Seo | | 39 | 54 | -15 |
| 2007-04-11 | @ TEX | 8 | W 6-5 | 3-5 | 4 | 33,674 | James Shields | Rob Tejeda | James Shields | Rob Tejeda | Alberto Reyes | 45 | 59 | -14 |
| 2007-04-12 | @ MIN | 9 | L 2-3 | 3-6 | 5 | 15,869 | Casey Fossum | Carlos Silva | Joe Nathan | Brian Stokes | | 47 | 62 | -15 |
| 2007-04-13 | @ MIN | 10 | W 4-2 | 4-6 | 5 | 27,783 | Scott Kazmir | Johan Santana | Scott Kazmir | Johan Santana | Alberto Reyes | 51 | 64 | -13 |
| 2007-04-14 | @ MIN | 11 | L 5-12 | 4-7 | 5 | 35,269 | Edwin Jackson | Sidney Ponson | Sidney Ponson | Edwin Jackson | | 56 | 76 | -20 |
| 2007-04-15 | @ MIN | 12 | W 6-4 | 5-7 | 5 | 27,024 | Jae Weong Seo | Boof Bonser | Brian Stokes | Joe Nathan | Alberto Reyes | 62 | 80 | -18 |
| 2007-04-16 | vs BAL | 13 | L 7-9 | 5-8 | 5 | 9,157 | James Shields | Adam Loewen | Jeremy Guthrie | Jae Kuk Ryu | Chris Ray | 69 | 89 | -20 |
| 2007-04-17 | vs BAL | 14 | W 6-4 | 6-8 | 5 | 9,575 | Casey Fossum | Steve Trachsel | Casey Fossum | Steve Trachsel | Alberto Reyes | 75 | 93 | -18 |
| 2007-04-18 | vs BAL | 15 | L 4-6 | 6-9 | 5 | 10,540 | Scott Kazmir | Erik Bedard | Erik Bedard | Gary Glover | Chris Ray | 79 | 99 | -20 |
| 2007-04-20 | vs CLE | 16 | L 3-4 | 6-10 | 5 | 13,391 | Edwin Jackson | CC Sabathia | Roberto Hernandez | Juan Salas | Joe Borowski | 82 | 103 | -21 |
| 2007-04-21 | vs CLE | 17 | W 6-5 | 7-10 | 5 | 22,805 | Jae Weong Seo | Paul Byrd | Jae Weong Seo | Paul Byrd | Alberto Reyes | 88 | 108 | -20 |
| 2007-04-22 | vs CLE | 18 | L 4-6 | 7-11 | 5 | 18,131 | James Shields | Jake Westbrook | Tom Mastny | Brian Stokes | Joe Borowski | 92 | 114 | -22 |
| 2007-04-23 | vs NYA | 19 | W 10-8 | 8-11 | 5 | 20,409 | Casey Fossum | Kei Igawa | Casey Fossum | Kei Igawa | | 102 | 122 | -20 |
| 2007-04-24 | vs NYA | 20 | W 6-4 | 9-11 | 4 | 22,328 | Scott Kazmir | Chien-Ming Wang | Juan Salas | Chien-Ming Wang | Alberto Reyes | 108 | 126 | -18 |
| 2007-04-25 | @ ANA | 21 | L 1-9 | 9-12 | 4 | 36,850 | Edwin Jackson | John Lackey | John Lackey | Edwin Jackson | | 109 | 135 | -26 |
| 2007-04-26 | @ ANA | 22 | L 3-11 | 9-13 | 4 | 35,597 | Jae Weong Seo | Bartolo Colon | Bartolo Colon | Jae Weong Seo | | 112 | 146 | -34 |
| 2007-04-27 | @ OAK | 23 | W 4-1 | 10-13 | 4 | 15,388 | James Shields | Chad Gaudin | James Shields | Chad Gaudin | Alberto Reyes | 116 | 147 | -31 |
| 2007-04-28 | @ OAK | 24 | L 5-12 | 10-14 | 4 | 26,760 | Casey Fossum | Dan Haren | Dan Haren | Casey Fossum | | 121 | 159 | -38 |
| 2007-04-29 | @ OAK | 25 | W 5-3 | 11-14 | 4 | 23,827 | Scott Kazmir | Dallas Braden | Scott Kazmir | Dallas Braden | Alberto Reyes | 126 | 162 | -36 |
| 2007-05-01 | vs MIN | 26 | L 1-9 | 11-15 | 4 | 8,773 | Edwin Jackson | Sidney Ponson | Sidney Ponson | Edwin Jackson | | 127 | 171 | -44 |
| 2007-05-02 | vs MIN | 27 | W 4-3 | 12-15 | 3 | 9,101 | Jae Weong Seo | Boof Bonser | Alberto Reyes | Matt Guerrier | | 131 | 174 | -43 |
| 2007-05-03 | vs MIN | 28 | W 6-4 | 13-15 | 2 | 8,793 | James Shields | Ramon Ortiz | James Shields | Ramon Ortiz | Alberto Reyes | 137 | 178 | -41 |
| 2007-05-04 | vs OAK | 29 | L 2-5 | 13-16 | 3 | 11,546 | Casey Fossum | Dan Haren | Justin Duchscherer | Gary Glover | Huston Street | 139 | 183 | -44 |
| 2007-05-05 | vs OAK | 30 | W 3-2 | 14-16 | 3 | 16,604 | Scott Kazmir | Joe Kennedy | Ruddy Lugo | Jay Marshall | | 142 | 185 | -43 |
| 2007-05-06 | vs OAK | 31 | L 3-5 | 14-17 | 4 | 16,880 | Edwin Jackson | Joe Blanton | Joe Blanton | Edwin Jackson | Huston Street | 145 | 190 | -45 |
| 2007-05-08 | @ BAL | 32 | L 3-8 | 14-18 | 4 | 17,818 | Jae Weong Seo | Jeremy Guthrie | Jeremy Guthrie | Jae Weong Seo | | 148 | 198 | -50 |
| 2007-05-09 | @ BAL | 33 | L 0-1 | 14-19 | 4 | 14,780 | James Shields | Erik Bedard | John Parrish | Brian Stokes | | 148 | 199 | -51 |
| 2007-05-10 | @ BAL | 34 | L 6-11 | 14-20 | 4 | 15,915 | Casey Fossum | Daniel Cabrera | Daniel Cabrera | Casey Fossum | | 154 | 210 | -56 |
| 2007-05-11 | @ TOR | 35 | L 1-5 | 14-21 | 4 | 20,542 | Scott Kazmir | A.J. Burnett | A.J. Burnett | Scott Kazmir | | 155 | 215 | -60 |
| 2007-05-12 | @ TOR | 36 | L 4-5 | 14-22 | 5 | 23,208 | Edwin Jackson | Dustin McGowan | Scott Downs | Brian Stokes | Jeremy Accardo | 159 | 220 | -61 |
| 2007-05-13 | @ TOR | 37 | W 2-1 | 15-22 | 4 | 25,453 | Jae Weong Seo | Shaun Marcum | Jae Weong Seo | Jason Frasor | Alberto Reyes | 161 | 221 | -60 |
| 2007-05-15 | vs TEX | 38 | W 4-3 | 16-22 | 5 | 8,443 | James Shields | Brandon McCarthy | Brian Stokes | Scott Feldman | | 165 | 224 | -59 |
| 2007-05-16 | vs TEX | 39 | W 11-8 | 17-22 | 5 | 8,839 | Casey Fossum | Vicente Padilla | Casey Fossum | Vicente Padilla | Alberto Reyes | 176 | 232 | -56 |
| 2007-05-17 | vs TEX | 40 | W 8-6 | 18-22 | 2 | 9,635 | Scott Kazmir | Kameron Loe | Gary Glover | Willie Eyre | | 184 | 238 | -54 |
| 2007-05-18 | vs FLO | 41 | L 4-8 | 18-23 | 3 | 13,003 | Edwin Jackson | Byung-Hyun Kim | Byung-Hyun Kim | Edwin Jackson | | 188 | 246 | -58 |
| 2007-05-19 | vs FLO | 42 | L 2-7 | 18-24 | 4 | 19,566 | Jae Weong Seo | Dontrelle Willis | Dontrelle Willis | Jae Weong Seo | | 190 | 253 | -63 |
| 2007-05-20 | vs FLO | 43 | L 3-4 | 18-25 | 5 | 23,554 | James Shields | Sergio Mitre | Sergio Mitre | Shawn Camp | Kevin Gregg | 193 | 257 | -64 |
| 2007-05-22 | vs SEA | 44 | L 2-5 | 18-26 | 5 | 9,254 | Scott Kazmir | Jarrod Washburn | Jarrod Washburn | Chad Orvella | J.J. Putz | 195 | 262 | -67 |
| 2007-05-23 | vs SEA | 45 | L 1-5 | 18-27 | 5 | 8,440 | Casey Fossum | Miguel Batista | Miguel Batista | Casey Fossum | | 196 | 267 | -71 |
| 2007-05-24 | vs SEA | 46 | W 13-12 | 19-27 | 5 | 9,149 | Jae Weong Seo | Horacio Ramirez | Jae Weong Seo | Sean White | Alberto Reyes | 209 | 279 | -70 |
| 2007-05-25 | @ CHA | 47 | L 4-5 | 19-28 | 5 | 34,538 | James Shields | Mark Buehrle | Bobby Jenks | Chad Orvella | | 213 | 284 | -71 |
| 2007-05-27 | @ CHA | 48 | W 11-5 | 20-28 | 4 | 38,103 | Scott Kazmir | Javier Vazquez | Scott Kazmir | Javier Vazquez | | 224 | 289 | -65 |
| 2007-05-28 | vs DET | 49 | W 6-5 | 21-28 | 4 | 14,769 | Edwin Jackson | Chad Durbin | Gary Glover | Todd Jones | | 230 | 294 | -64 |
| 2007-05-29 | vs DET | 50 | L 2-14 | 21-29 | 4 | 11,518 | Casey Fossum | Jeremy Bonderman | Jeremy Bonderman | Casey Fossum | | 232 | 308 | -76 |
| 2007-05-30 | vs DET | 51 | W 5-3 | 22-29 | 4 | 12,435 | James Shields | Nate Robertson | James Shields | Nate Robertson | | 237 | 311 | -74 |
| 2007-06-01 | vs KCA | 52 | L 1-4 | 22-30 | 4 | 12,032 | Scott Kazmir | Brian Bannister | Brian Bannister | Scott Kazmir | Octavio Dotel | 238 | 315 | -77 |
| 2007-06-02 | vs KCA | 53 | L 4-9 | 22-31 | 4 | 14,403 | Edwin Jackson | Odalis Perez | Odalis Perez | Edwin Jackson | | 242 | 324 | -82 |
| 2007-06-03 | vs KCA | 54 | W 5-1 | 23-31 | 4 | 12,220 | J.P. Howell | Scott Elarton | J.P. Howell | Scott Elarton | | 247 | 325 | -78 |
| 2007-06-04 | vs KCA | 55 | W 4-2 | 24-31 | 4 | 9,435 | James Shields | Gil Meche | James Shields | Gil Meche | Alberto Reyes | 251 | 327 | -76 |
| 2007-06-05 | @ TOR | 56 | L 11-12 | 24-32 | 4 | 19,063 | Andy Sonnanstine | Roy Halladay | Josh Towers | Casey Fossum | | 262 | 339 | -77 |
| 2007-06-06 | @ TOR | 57 | W 6-2 | 25-32 | 4 | 16,663 | Scott Kazmir | Tomo Ohka | Scott Kazmir | Tomo Ohka | | 268 | 341 | -73 |
| 2007-06-07 | @ TOR | 58 | W 5-3 | 26-32 | 4 | 37,105 | Edwin Jackson | A.J. Burnett | Gary Glover | Jeremy Accardo | Alberto Reyes | 273 | 344 | -71 |
| 2007-06-08 | @ FLO | 59 | L 8-14 | 26-33 | 5 | 13,520 | J.P. Howell | Byung-Hyun Kim | Justin Miller | Brian Stokes | | 281 | 358 | -77 |
| 2007-06-09 | @ FLO | 60 | W 7-2 | 27-33 | 5 | 20,189 | James Shields | Dontrelle Willis | James Shields | Dontrelle Willis | | 288 | 360 | -72 |
| 2007-06-10 | @ FLO | 61 | W 9-4 | 28-33 | 5 | 11,525 | Andy Sonnanstine | Rick Vanden Hurk | Andy Sonnanstine | Rick Vanden Hurk | | 297 | 364 | -67 |
| 2007-06-12 | vs SDN | 62 | W 11-4 | 29-33 | 4 | 12,870 | Scott Kazmir | Greg Maddux | Casey Fossum | Cla Meredith | | 308 | 368 | -60 |
| 2007-06-13 | vs SDN | 63 | L 0-9 | 29-34 | 4 | 12,020 | Edwin Jackson | Jake Peavy | Jake Peavy | Edwin Jackson | | 308 | 377 | -69 |
| 2007-06-14 | vs SDN | 64 | L 1-7 | 29-35 | 4 | 19,270 | J.P. Howell | Justin Germano | Justin Germano | J.P. Howell | | 309 | 384 | -75 |
| 2007-06-15 | @ COL | 65 | L 2-12 | 29-36 | 4 | 25,762 | James Shields | Rodrigo Lopez | Rodrigo Lopez | James Shields | | 311 | 396 | -85 |
| 2007-06-16 | @ COL | 66 | L 5-10 | 29-37 | 4 | 30,101 | Andy Sonnanstine | Jason Hirsh | Taylor Buchholz | Andy Sonnanstine | | 316 | 406 | -90 |
| 2007-06-17 | @ COL | 67 | W 7-4 | 30-37 | 4 | 31,190 | Scott Kazmir | Aaron Cook | Scott Kazmir | Aaron Cook | Alberto Reyes | 323 | 410 | -87 |
| 2007-06-18 | @ ARI | 68 | W 10-2 | 31-37 | 4 | 18,963 | Edwin Jackson | Livan Hernandez | Jason Hammel | Livan Hernandez | | 333 | 412 | -79 |
| 2007-06-19 | @ ARI | 69 | L 8-10 | 31-38 | 4 | 19,761 | J.P. Howell | Doug Davis | Brandon Lyon | Alberto Reyes | | 341 | 422 | -81 |
| 2007-06-20 | @ ARI | 70 | L 4-7 | 31-39 | 4 | 31,805 | James Shields | Micah Owings | Micah Owings | James Shields | Jose Valverde | 345 | 429 | -84 |
| 2007-06-22 | vs LAN | 71 | L 3-6 | 31-40 | 5 | 14,961 | Andy Sonnanstine | Derek Lowe | Derek Lowe | Andy Sonnanstine | Takashi Saito | 348 | 435 | -87 |
| 2007-06-23 | vs LAN | 72 | W 4-3 | 32-40 | 4 | 24,068 | Scott Kazmir | Randy Wolf | Casey Fossum | Randy Wolf | Alberto Reyes | 352 | 438 | -86 |
| 2007-06-24 | vs LAN | 73 | W 9-4 | 33-40 | 4 | 18,248 | Edwin Jackson | Hong-Chih Kuo | Edwin Jackson | Hong-Chih Kuo | | 361 | 442 | -81 |
| 2007-06-25 | vs CHA | 74 | L 4-5 | 33-41 | 4 | 10,514 | J.P. Howell | John Danks | John Danks | Casey Fossum | Bobby Jenks | 365 | 447 | -82 |
| 2007-06-26 | vs CHA | 75 | L 1-6 | 33-42 | 4 | 11,954 | James Shields | Jon Garland | Jon Garland | James Shields | | 366 | 453 | -87 |
| 2007-06-27 | vs CHA | 76 | L 3-5 | 33-43 | 5 | 10,492 | Andy Sonnanstine | Mark Buehrle | Mark Buehrle | Gary Glover | Bobby Jenks | 369 | 458 | -89 |
| 2007-06-28 | vs CHA | 77 | L 1-5 | 33-44 | 5 | 13,496 | Scott Kazmir | Javier Vazquez | Javier Vazquez | Scott Kazmir | | 370 | 463 | -93 |
| 2007-06-29 | @ CLE | 78 | L 1-2 | 33-45 | 5 | 34,557 | Edwin Jackson | Jake Westbrook | Joe Borowski | Shawn Camp | | 371 | 465 | -94 |
| 2007-06-30 | @ CLE | 79 | L 6-8 | 33-46 | 5 | 36,726 | J.P. Howell | CC Sabathia | CC Sabathia | J.P. Howell | Joe Borowski | 377 | 473 | -96 |
| 2007-07-01 | @ CLE | 80 | L 2-3 | 33-47 | 5 | 30,410 | James Shields | Cliff Lee | Cliff Lee | James Shields | Joe Borowski | 379 | 476 | -97 |
| 2007-07-02 | @ CLE | 81 | L 2-10 | 33-48 | 5 | 34,372 | Andy Sonnanstine | Fausto Carmona | Fausto Carmona | Andy Sonnanstine | | 381 | 486 | -105 |
| 2007-07-03 | @ BOS | 82 | L 1-4 | 33-49 | 5 | 37,005 | Scott Kazmir | Daisuke Matsuzaka | Daisuke Matsuzaka | Scott Kazmir | | 382 | 490 | -108 |
| 2007-07-04 | @ BOS | 83 | L 5-7 | 33-50 | 5 | 36,629 | Edwin Jackson | Tim Wakefield | Tim Wakefield | Edwin Jackson | Jonathan Papelbon | 387 | 497 | -110 |
| 2007-07-05 | @ BOS | 84 | L 4-15 | 33-51 | 5 | 37,044 | J.P. Howell | Josh Beckett | Josh Beckett | J.P. Howell | | 391 | 512 | -121 |
| 2007-07-06 | @ KCA | 85 | W 6-5 | 34-51 | 5 | 18,753 | James Shields | Odalis Perez | James Shields | Odalis Perez | Gary Glover | 397 | 517 | -120 |
| 2007-07-07 | @ KCA | 86 | L 7-8 | 34-52 | 5 | 20,458 | Andy Sonnanstine | Gil Meche | Octavio Dotel | Shawn Camp | | 404 | 525 | -121 |
| 2007-07-08 | @ KCA | 87 | L 4-12 | 34-53 | 5 | 14,726 | Scott Kazmir | Jorge de la Rosa | Jorge de la Rosa | Scott Kazmir | | 408 | 537 | -129 |
| 2007-07-12 | vs NYA | 88 | L 3-7 | 34-54 | 5 | 21,907 | James Shields | Andy Pettitte | Andy Pettitte | James Shields | | 411 | 544 | -133 |
| 2007-07-13 | vs NYA | 89 | W 6-4 | 35-54 | 5 | 29,803 | Scott Kazmir | Roger Clemens | Scott Kazmir | Roger Clemens | Gary Glover | 417 | 548 | -131 |
| 2007-07-14 | vs NYA | 90 | L 4-6 | 35-55 | 5 | 36,048 | Andy Sonnanstine | Chien-Ming Wang | Chien-Ming Wang | Andy Sonnanstine | Mariano Rivera | 421 | 554 | -133 |
| 2007-07-15 | vs NYA | 91 | L 6-7 | 35-56 | 5 | 36,048 | Edwin Jackson | Mike Mussina | Luis Vizcaino | Casey Fossum | Mariano Rivera | 427 | 561 | -134 |
| 2007-07-17 | vs ANA | 92 | W 8-3 | 36-56 | 5 | 9,430 | James Shields | Ervin Santana | James Shields | Ervin Santana | | 435 | 564 | -129 |
| 2007-07-18 | vs ANA | 93 | W 7-2 | 37-56 | 5 | 13,521 | Scott Kazmir | Bartolo Colon | Scott Kazmir | Bartolo Colon | | 442 | 566 | -124 |
| 2007-07-19 | vs ANA | 94 | L 0-3 | 37-57 | 5 | 18,163 | Andy Sonnanstine | Kelvim Escobar | Kelvim Escobar | Andy Sonnanstine | Francisco Rodriguez | 442 | 569 | -127 |
| 2007-07-20 | @ NYA | 95 | W 14-4 | 38-57 | 5 | 53,957 | Edwin Jackson | Mike Mussina | Edwin Jackson | Mike Mussina | | 456 | 573 | -117 |
| 2007-07-21 | @ NYA | 96 | L 3-7 | 38-58 | 5 | 54,412 | Jason Hammel | Kei Igawa | Luis Vizcaino | Jae Kuk Ryu | | 459 | 580 | -121 |
| 2007-07-21 | @ NYA | 97 | L 5-17 | 38-58 | 5 | 52,983 | J.P. Howell | Matt DeSalvo | Luis Vizcaino | J.P. Howell | | 464 | 597 | -133 |
| 2007-07-22 | @ NYA | 98 | L 4-21 | 38-59 | 5 | 54,751 | James Shields | Andy Pettitte | Andy Pettitte | James Shields | | 468 | 618 | -150 |
| 2007-07-24 | @ BAL | 99 | L 0-3 | 38-60 | 5 | 42,579 | Scott Kazmir | Daniel Cabrera | Daniel Cabrera | Scott Kazmir | Jamie Walker | 468 | 621 | -153 |
| 2007-07-25 | @ BAL | 100 | L 1-6 | 38-61 | 5 | 21,427 | Andy Sonnanstine | Erik Bedard | Erik Bedard | Andy Sonnanstine | | 469 | 627 | -158 |
| 2007-07-26 | @ BAL | 101 | L 7-10 | 38-62 | 5 | 22,393 | Edwin Jackson | Steve Trachsel | Rob Bell | Edwin Jackson | | 476 | 637 | -161 |
| 2007-07-27 | vs BOS | 102 | L 1-7 | 38-63 | 5 | 33,144 | Jason Hammel | Tim Wakefield | Tim Wakefield | Jason Hammel | | 477 | 644 | -167 |
| 2007-07-28 | vs BOS | 103 | L 6-12 | 38-64 | 5 | 36,048 | James Shields | Jon Lester | Kyle Snyder | Brian Stokes | | 483 | 656 | -173 |
| 2007-07-29 | vs BOS | 104 | W 5-2 | 39-64 | 5 | 34,813 | Scott Kazmir | Daisuke Matsuzaka | Gary Glover | Daisuke Matsuzaka | | 488 | 658 | -170 |
| 2007-07-30 | vs TOR | 105 | W 5-4 | 40-64 | 5 | 8,807 | Andy Sonnanstine | Dustin McGowan | Scott Dohmann | Brian Wolfe | | 493 | 662 | -169 |
| 2007-07-31 | vs TOR | 106 | L 0-2 | 40-65 | 5 | 10,569 | Edwin Jackson | Jesse Litsch | Jesse Litsch | Edwin Jackson | Jeremy Accardo | 493 | 664 | -171 |
| 2007-08-01 | vs TOR | 107 | W 6-2 | 41-65 | 5 | 10,109 | Jason Hammel | Josh Towers | Gary Glover | Josh Towers | | 499 | 666 | -167 |
| 2007-08-03 | vs BAL | 108 | L 1-3 | 41-66 | 5 | 15,542 | James Shields | Daniel Cabrera | Daniel Cabrera | James Shields | Danys Baez | 500 | 669 | -169 |
| 2007-08-04 | vs BAL | 109 | W 9-2 | 42-66 | 5 | 18,230 | Scott Kazmir | Brian Burres | Scott Kazmir | Brian Burres | | 509 | 671 | -162 |
| 2007-08-05 | vs BAL | 110 | L 3-11 | 42-67 | 5 | 19,845 | Andy Sonnanstine | Erik Bedard | Erik Bedard | Andy Sonnanstine | | 512 | 682 | -170 |
| 2007-08-06 | @ DET | 111 | L 4-6 | 42-68 | 5 | 39,289 | Edwin Jackson | Justin Verlander | Zach Miner | Gary Glover | Todd Jones | 516 | 688 | -172 |
| 2007-08-07 | @ DET | 112 | L 6-9 | 42-69 | 5 | 35,288 | Jason Hammel | Nate Robertson | Tim Byrdak | Dan Wheeler | Todd Jones | 522 | 697 | -175 |
| 2007-08-08 | @ DET | 113 | W 7-1 | 43-69 | 5 | 37,777 | James Shields | Chad Durbin | James Shields | Chad Durbin | | 529 | 698 | -169 |
| 2007-08-09 | @ DET | 114 | W 8-1 | 44-69 | 5 | 38,789 | Scott Kazmir | Jeremy Bonderman | Scott Kazmir | Jeremy Bonderman | | 537 | 699 | -162 |
| 2007-08-10 | @ TEX | 115 | L 4-7 | 44-70 | 5 | 28,314 | Andy Sonnanstine | Brandon McCarthy | Mike Wood | Andy Sonnanstine | C.J. Wilson | 541 | 706 | -165 |
| 2007-08-11 | @ TEX | 116 | W 3-0 | 45-70 | 5 | 36,709 | Edwin Jackson | John Rheinecker | Edwin Jackson | John Rheinecker | | 544 | 706 | -162 |
| 2007-08-12 | @ TEX | 117 | L 1-9 | 45-71 | 5 | 24,042 | Jason Hammel | Kason Gabbard | Willie Eyre | Jason Hammel | | 545 | 715 | -170 |
| 2007-08-13 | @ BOS | 118 | L 0-3 | 45-72 | 5 | 36,808 | James Shields | Tim Wakefield | Tim Wakefield | James Shields | Jonathan Papelbon | 545 | 718 | -173 |
| 2007-08-14 | @ BOS | 119 | L 1-2 | 45-73 | 5 | 36,837 | Scott Kazmir | Jon Lester | Eric Gagne | Alberto Reyes | | 546 | 720 | -174 |
| 2007-08-15 | @ BOS | 120 | W 6-5 | 46-73 | 5 | 36,413 | Andy Sonnanstine | Daisuke Matsuzaka | Andy Sonnanstine | Daisuke Matsuzaka | Alberto Reyes | 552 | 725 | -173 |
| 2007-08-17 | vs CLE | 121 | L 1-2 | 46-74 | 5 | 15,343 | Edwin Jackson | Paul Byrd | Paul Byrd | Edwin Jackson | Joe Borowski | 553 | 727 | -174 |
| 2007-08-18 | vs CLE | 122 | L 1-8 | 46-75 | 5 | 24,397 | Jason Hammel | Jake Westbrook | Jake Westbrook | Jason Hammel | | 554 | 735 | -181 |
| 2007-08-19 | vs CLE | 123 | W 4-3 | 47-75 | 5 | 22,328 | James Shields | CC Sabathia | Scott Dohmann | Rafael Perez | | 558 | 738 | -180 |
| 2007-08-20 | vs BOS | 124 | L 0-6 | 47-76 | 5 | 16,843 | Scott Kazmir | Tim Wakefield | Tim Wakefield | Scott Kazmir | | 558 | 744 | -186 |
| 2007-08-21 | vs BOS | 125 | L 6-8 | 47-77 | 5 | 16,393 | Andy Sonnanstine | Jon Lester | Jon Lester | Andy Sonnanstine | Jonathan Papelbon | 564 | 752 | -188 |
| 2007-08-22 | vs BOS | 126 | W 2-1 | 48-77 | 5 | 17,839 | Edwin Jackson | Daisuke Matsuzaka | Edwin Jackson | Daisuke Matsuzaka | Alberto Reyes | 566 | 753 | -187 |
| 2007-08-23 | vs OAK | 127 | L 2-12 | 48-78 | 5 | 9,444 | Jason Hammel | Chad Gaudin | Chad Gaudin | Jason Hammel | | 568 | 765 | -197 |
| 2007-08-24 | vs OAK | 128 | W 12-2 | 49-78 | 5 | 9,592 | James Shields | Lenny DiNardo | James Shields | Lenny DiNardo | | 580 | 767 | -187 |
| 2007-08-25 | vs OAK | 129 | W 14-3 | 50-78 | 5 | 18,163 | Scott Kazmir | Joe Blanton | Scott Kazmir | Joe Blanton | | 594 | 770 | -176 |
| 2007-08-26 | vs OAK | 130 | W 7-4 | 51-78 | 5 | 19,044 | Andy Sonnanstine | Dan Haren | Andy Sonnanstine | Dan Haren | Alberto Reyes | 601 | 774 | -173 |
| 2007-08-27 | @ CHA | 131 | L 4-5 | 51-79 | 5 | 37,030 | Edwin Jackson | Jose Contreras | Jose Contreras | Dan Wheeler | Bobby Jenks | 605 | 779 | -174 |
| 2007-08-28 | @ BAL | 132 | W 15-8 | 52-79 | 5 | 17,781 | Jason Hammel | Daniel Cabrera | Scott Dohmann | Jim Hoey | | 620 | 787 | -167 |
| 2007-08-29 | @ BAL | 133 | W 5-4 | 53-79 | 5 | 16,944 | James Shields | Steve Trachsel | Grant Balfour | Rob Bell | Alberto Reyes | 625 | 791 | -166 |
| 2007-08-30 | @ BAL | 134 | W 8-6 | 54-79 | 5 | 17,546 | Scott Kazmir | Jeremy Guthrie | Scott Kazmir | Jeremy Guthrie | Alberto Reyes | 633 | 797 | -164 |
| 2007-08-31 | @ NYA | 135 | W 9-1 | 55-79 | 5 | 53,275 | Andy Sonnanstine | Phil Hughes | Andy Sonnanstine | Phil Hughes | | 642 | 798 | -156 |
| 2007-09-01 | @ NYA | 136 | L 6-9 | 55-80 | 5 | 53,637 | Edwin Jackson | Ian Kennedy | Ian Kennedy | Edwin Jackson | Mariano Rivera | 648 | 807 | -159 |
| 2007-09-02 | @ NYA | 137 | W 8-2 | 56-80 | 5 | 53,957 | Jason Hammel | Andy Pettitte | Jason Hammel | Andy Pettitte | | 656 | 809 | -153 |
| 2007-09-03 | vs BAL | 138 | W 9-7 | 57-80 | 5 | 10,350 | James Shields | Kurt Birkins | James Shields | Jim Hoey | | 665 | 816 | -151 |
| 2007-09-04 | vs BAL | 139 | L 4-8 | 57-81 | 5 | 9,112 | Scott Kazmir | Jeremy Guthrie | Chad Bradford | Dan Wheeler | | 669 | 824 | -155 |
| 2007-09-05 | vs BAL | 140 | W 17-2 | 58-81 | 5 | 9,856 | Andy Sonnanstine | Radhames Liz | Andy Sonnanstine | Radhames Liz | | 686 | 826 | -140 |
| 2007-09-07 | vs TOR | 141 | L 2-7 | 58-82 | 5 | 18,617 | Edwin Jackson | Dustin McGowan | Dustin McGowan | Edwin Jackson | | 688 | 833 | -145 |
| 2007-09-08 | vs TOR | 142 | W 5-4 | 59-82 | 5 | 19,822 | Jason Hammel | A.J. Burnett | Alberto Reyes | Jeremy Accardo | | 693 | 837 | -144 |
| 2007-09-09 | vs TOR | 143 | W 3-2 | 60-82 | 5 | 20,556 | James Shields | Jesse Litsch | James Shields | Jesse Litsch | Alberto Reyes | 696 | 839 | -143 |
| 2007-09-10 | @ BOS | 144 | W 1-0 | 61-82 | 5 | 36,907 | Scott Kazmir | Curt Schilling | Scott Kazmir | Curt Schilling | Alberto Reyes | 697 | 839 | -142 |
| 2007-09-11 | @ BOS | 145 | L 10-16 | 61-83 | 5 | 36,640 | Andy Sonnanstine | Tim Wakefield | Bryan Corey | Jon Switzer | | 707 | 855 | -148 |
| 2007-09-12 | @ BOS | 146 | L 4-5 | 61-84 | 5 | 36,931 | Edwin Jackson | Jon Lester | Jonathan Papelbon | Alberto Reyes | | 711 | 860 | -149 |
| 2007-09-13 | @ SEA | 147 | L 7-8 | 61-85 | 5 | 23,991 | Jason Hammel | Jeff Weaver | Ryan Rowland-Smith | Dan Wheeler | J.J. Putz | 718 | 868 | -150 |
| 2007-09-14 | @ SEA | 148 | L 1-2 | 61-86 | 5 | 30,164 | James Shields | Felix Hernandez | J.J. Putz | Gary Glover | | 719 | 870 | -151 |
| 2007-09-15 | @ SEA | 149 | W 6-2 | 62-86 | 5 | 33,793 | Scott Kazmir | Horacio Ramirez | Scott Kazmir | Horacio Ramirez | | 725 | 872 | -147 |
| 2007-09-16 | @ SEA | 150 | W 9-2 | 63-86 | 5 | 36,234 | Andy Sonnanstine | Jarrod Washburn | Andy Sonnanstine | Jarrod Washburn | | 734 | 874 | -140 |
| 2007-09-17 | @ ANA | 151 | L 7-10 | 63-87 | 5 | 37,530 | Edwin Jackson | Kelvim Escobar | Darren Oliver | Edwin Jackson | | 741 | 884 | -143 |
| 2007-09-18 | @ ANA | 152 | L 1-2 | 63-88 | 5 | 36,313 | Jason Hammel | John Lackey | John Lackey | Jason Hammel | Francisco Rodriguez | 742 | 886 | -144 |
| 2007-09-19 | @ ANA | 153 | L 1-2 | 63-89 | 5 | 33,699 | J.P. Howell | Ervin Santana | Ervin Santana | J.P. Howell | Francisco Rodriguez | 743 | 888 | -145 |
| 2007-09-21 | vs BOS | 154 | L 1-8 | 63-90 | 5 | 27,369 | Scott Kazmir | Josh Beckett | Josh Beckett | Scott Kazmir | | 744 | 896 | -152 |
| 2007-09-22 | vs BOS | 155 | L 6-8 | 63-91 | 5 | 34,626 | Andy Sonnanstine | Daisuke Matsuzaka | Eric Gagne | Alberto Reyes | Jonathan Papelbon | 750 | 904 | -154 |
| 2007-09-23 | vs BOS | 156 | W 5-4 | 64-91 | 5 | 30,310 | Edwin Jackson | Tim Wakefield | Edwin Jackson | Tim Wakefield | Alberto Reyes | 755 | 908 | -153 |
| 2007-09-25 | vs NYA | 157 | W 7-6 | 65-91 | 5 | 24,503 | Jason Hammel | Kei Igawa | Gary Glover | Jeff Karstens | | 762 | 914 | -152 |
| 2007-09-26 | vs NYA | 158 | L 4-12 | 65-92 | 5 | 21,621 | J.P. Howell | Chien-Ming Wang | Chien-Ming Wang | J.P. Howell | | 766 | 926 | -160 |
| 2007-09-27 | vs NYA | 159 | L 1-3 | 65-93 | 5 | 28,962 | Scott Kazmir | Phil Hughes | Phil Hughes | Jon Switzer | Jose Veras | 767 | 929 | -162 |
| 2007-09-28 | @ TOR | 160 | L 4-5 | 65-94 | 5 | 34,670 | Andy Sonnanstine | Dustin McGowan | Dustin McGowan | Andy Sonnanstine | Jeremy Accardo | 771 | 934 | -163 |
| 2007-09-29 | @ TOR | 161 | L 3-5 | 65-95 | 5 | 37,681 | Edwin Jackson | Jesse Litsch | Scott Downs | Dan Wheeler | | 774 | 939 | -165 |
| 2007-09-30 | @ TOR | 162 | W 8-5 | 66-95 | 5 | 44,156 | Jason Hammel | A.J. Burnett | Jason Hammel | A.J. Burnett | Alberto Reyes | 782 | 944 | -162 |