| 2007-04-01 | vs NYN | 1 | L 1-6 | 0-1 | 6 | 45,429 | Chris Carpenter | Tom Glavine | Tom Glavine | Chris Carpenter | | 1 | 6 | -5 |
| 2007-04-03 | vs NYN | 2 | L 1-4 | 0-2 | 6 | 45,440 | Kip Wells | Orlando Hernandez | Orlando Hernandez | Kip Wells | Billy Wagner | 2 | 10 | -8 |
| 2007-04-04 | vs NYN | 3 | L 0-10 | 0-3 | 6 | 45,423 | Braden Looper | John Maine | John Maine | Braden Looper | | 2 | 20 | -18 |
| 2007-04-06 | @ HOU | 4 | W 4-2 | 1-3 | 5 | 43,430 | Adam Wainwright | Wandy Rodriguez | Adam Wainwright | Wandy Rodriguez | Jason Isringhausen | 6 | 22 | -16 |
| 2007-04-07 | @ HOU | 5 | L 1-5 | 1-4 | 6 | 41,885 | Anthony Reyes | Roy Oswalt | Roy Oswalt | Anthony Reyes | | 7 | 27 | -20 |
| 2007-04-08 | @ HOU | 6 | W 10-1 | 2-4 | 5 | 36,273 | Kip Wells | Jason Jennings | Kip Wells | Jason Jennings | | 17 | 28 | -11 |
| 2007-04-09 | @ PIT | 7 | W 3-0 | 3-4 | 5 | 38,429 | Braden Looper | Ian Snell | Braden Looper | Ian Snell | Jason Isringhausen | 20 | 28 | -8 |
| 2007-04-10 | @ PIT | 8 | W 3-2 | 4-4 | 4 | 12,468 | Randy Keisler | Tom Gorzelanny | Brad Thompson | John Wasdin | Jason Isringhausen | 23 | 30 | -7 |
| 2007-04-11 | @ PIT | 9 | W 3-2 | 5-4 | 3 | 9,959 | Adam Wainwright | Paul Maholm | Ryan Franklin | Salomon Torres | | 26 | 32 | -6 |
| 2007-04-14 | vs MIL | 10 | L 2-3 | 5-5 | 3 | 42,805 | Kip Wells | Jeff Suppan | Jeff Suppan | Kip Wells | Francisco Cordero | 28 | 35 | -7 |
| 2007-04-15 | vs MIL | 11 | W 10-2 | 6-5 | 3 | 44,153 | Braden Looper | Ben Sheets | Braden Looper | Ben Sheets | | 38 | 37 | 1 |
| 2007-04-16 | vs PIT | 12 | L 2-3 | 6-6 | 3 | 43,026 | Anthony Reyes | Ian Snell | Ian Snell | Anthony Reyes | Salomon Torres | 40 | 40 | 0 |
| 2007-04-17 | vs PIT | 13 | L 1-6 | 6-7 | 5 | 42,446 | Adam Wainwright | Tom Gorzelanny | Tom Gorzelanny | Adam Wainwright | | 41 | 46 | -5 |
| 2007-04-18 | @ SFN | 14 | L 5-6 | 6-8 | 5 | 40,532 | Randy Keisler | Matt Morris | Jonathan Sanchez | Josh Hancock | | 46 | 52 | -6 |
| 2007-04-19 | @ SFN | 15 | L 2-6 | 6-9 | 6 | 37,398 | Kip Wells | Noah Lowry | Noah Lowry | Kip Wells | Brad Hennessey | 48 | 58 | -10 |
| 2007-04-20 | @ CHN | 16 | W 2-1 | 7-9 | 4 | 38,955 | Braden Looper | Ted Lilly | Braden Looper | Ted Lilly | Jason Isringhausen | 50 | 59 | -9 |
| 2007-04-21 | @ CHN | 17 | L 0-6 | 7-10 | 5 | 41,637 | Anthony Reyes | Jason Marquis | Jason Marquis | Anthony Reyes | | 50 | 65 | -15 |
| 2007-04-22 | @ CHN | 18 | W 12-9 | 8-10 | 4 | 40,193 | Adam Wainwright | Wade Miller | Jason Isringhausen | Ryan Dempster | | 62 | 74 | -12 |
| 2007-04-24 | vs CIN | 19 | L 3-10 | 8-11 | 5 | 42,309 | Kip Wells | Aaron Harang | Aaron Harang | Kip Wells | | 65 | 84 | -19 |
| 2007-04-25 | vs CIN | 20 | W 5-2 | 9-11 | 5 | 42,225 | Braden Looper | Bronson Arroyo | Randy Flores | Kirk Saarloos | Jason Isringhausen | 70 | 86 | -16 |
| 2007-04-26 | vs CIN | 21 | W 7-5 | 10-11 | 3 | 42,503 | Randy Keisler | Kyle Lohse | Russ Springer | Kyle Lohse | Jason Isringhausen | 77 | 91 | -14 |
| 2007-04-27 | vs CHN | 22 | L 3-5 | 10-12 | 3 | 45,131 | Anthony Reyes | Jason Marquis | Jason Marquis | Anthony Reyes | Ryan Dempster | 80 | 96 | -16 |
| 2007-04-28 | vs CHN | 23 | L 1-8 | 10-13 | 6 | 45,015 | Adam Wainwright | Carlos Zambrano | Carlos Zambrano | Adam Wainwright | | 81 | 104 | -23 |
| 2007-04-30 | @ MIL | 24 | L 1-7 | 10-14 | 6 | 20,191 | Kip Wells | Jeff Suppan | Jeff Suppan | Kip Wells | | 82 | 111 | -29 |
| 2007-05-01 | @ MIL | 25 | L 2-12 | 10-15 | 6 | 20,446 | Braden Looper | Ben Sheets | Ben Sheets | Braden Looper | | 84 | 123 | -39 |
| 2007-05-02 | @ MIL | 26 | L 0-4 | 10-16 | 6 | 23,299 | Anthony Reyes | Chris Capuano | Carlos Villanueva | Anthony Reyes | | 84 | 127 | -43 |
| 2007-05-04 | vs HOU | 27 | W 3-2 | 11-16 | 6 | 44,117 | Adam Wainwright | Woody Williams | Adam Wainwright | Woody Williams | Jason Isringhausen | 87 | 129 | -42 |
| 2007-05-05 | vs HOU | 28 | L 0-13 | 11-17 | 6 | 44,881 | Kip Wells | Matt Albers | Matt Albers | Kip Wells | | 87 | 142 | -55 |
| 2007-05-06 | vs HOU | 29 | W 3-1 | 12-17 | 6 | 44,483 | Braden Looper | Chris Sampson | Braden Looper | Chris Sampson | Jason Isringhausen | 90 | 143 | -53 |
| 2007-05-07 | vs COL | 30 | L 2-3 | 12-18 | 6 | 42,285 | Anthony Reyes | Jeff Francis | Zach McClellan | Brian Falkenborg | Brian Fuentes | 92 | 146 | -54 |
| 2007-05-08 | vs COL | 31 | W 4-1 | 13-18 | 6 | 42,763 | Brad Thompson | Taylor Buchholz | Kelvin Jimenez | Denny Bautista | Jason Isringhausen | 96 | 147 | -51 |
| 2007-05-09 | vs COL | 32 | W 9-2 | 14-18 | 5 | 43,001 | Adam Wainwright | Jason Hirsh | Adam Wainwright | Jason Hirsh | | 105 | 149 | -44 |
| 2007-05-11 | @ SDN | 33 | L 0-7 | 14-19 | 5 | 38,901 | Kip Wells | Jake Peavy | Jake Peavy | Kip Wells | | 105 | 156 | -51 |
| 2007-05-12 | @ SDN | 34 | W 5-0 | 15-19 | 4 | 44,082 | Braden Looper | Chris Young | Braden Looper | Chris Young | | 110 | 156 | -46 |
| 2007-05-13 | @ SDN | 35 | L 0-3 | 15-20 | 5 | 36,616 | Anthony Reyes | Justin Germano | Justin Germano | Anthony Reyes | Trevor Hoffman | 110 | 159 | -49 |
| 2007-05-14 | @ LAN | 36 | W 8-4 | 16-20 | 5 | 35,707 | Brad Thompson | Brett Tomko | Brad Thompson | Brett Tomko | Jason Isringhausen | 118 | 163 | -45 |
| 2007-05-15 | @ LAN | 37 | L 7-9 | 16-21 | 5 | 38,954 | Adam Wainwright | Derek Lowe | Derek Lowe | Adam Wainwright | Takashi Saito | 125 | 172 | -47 |
| 2007-05-16 | @ LAN | 38 | L 4-5 | 16-22 | 5 | 38,252 | Kip Wells | Randy Wolf | Randy Wolf | Kip Wells | Takashi Saito | 129 | 177 | -48 |
| 2007-05-18 | @ DET | 39 | L 4-14 | 16-23 | 5 | 40,816 | Braden Looper | Andrew Miller | Andrew Miller | Braden Looper | | 133 | 191 | -58 |
| 2007-05-19 | @ DET | 40 | L 7-8 | 16-24 | 5 | 42,625 | Anthony Reyes | Nate Robertson | Nate Robertson | Anthony Reyes | Todd Jones | 140 | 199 | -59 |
| 2007-05-20 | @ DET | 41 | L 3-6 | 16-25 | 5 | 39,562 | Brad Thompson | Justin Verlander | Justin Verlander | Brad Thompson | Bobby Seay | 143 | 205 | -62 |
| 2007-05-22 | vs PIT | 42 | W 9-4 | 17-25 | 5 | 42,679 | Adam Wainwright | Zach Duke | Adam Wainwright | Zach Duke | | 152 | 209 | -57 |
| 2007-05-23 | vs PIT | 43 | W 5-3 | 18-25 | 5 | 42,245 | Kip Wells | Ian Snell | Kip Wells | Ian Snell | Jason Isringhausen | 157 | 212 | -55 |
| 2007-05-24 | vs PIT | 44 | W 3-1 | 19-25 | 4 | 44,296 | Braden Looper | Tom Gorzelanny | Braden Looper | Tom Gorzelanny | Jason Isringhausen | 160 | 213 | -53 |
| 2007-05-25 | vs WAS | 45 | L 4-5 | 19-26 | 5 | 43,618 | Anthony Reyes | Micah Bowie | Micah Bowie | Anthony Reyes | Chad Cordero | 164 | 218 | -54 |
| 2007-05-26 | vs WAS | 46 | W 8-6 | 20-26 | 4 | 44,270 | Brad Thompson | Levale Speigner | Brad Thompson | Levale Speigner | Jason Isringhausen | 172 | 224 | -52 |
| 2007-05-27 | vs WAS | 47 | L 2-7 | 20-27 | 4 | 44,578 | Adam Wainwright | Matt Chico | Saul Rivera | Adam Wainwright | | 174 | 231 | -57 |
| 2007-05-28 | @ COL | 48 | L 2-6 | 20-28 | 5 | 31,575 | Kip Wells | Jeff Francis | Jeff Francis | Kip Wells | | 176 | 237 | -61 |
| 2007-05-29 | @ COL | 49 | L 3-8 | 20-29 | 5 | 18,213 | Braden Looper | Rodrigo Lopez | Rodrigo Lopez | Braden Looper | | 179 | 245 | -66 |
| 2007-05-30 | @ COL | 50 | W 8-4 | 21-29 | 4 | 19,062 | Todd Wellemeyer | Jason Hirsh | Todd Wellemeyer | Jason Hirsh | | 187 | 249 | -62 |
| 2007-05-31 | @ COL | 51 | W 7-3 | 22-29 | 4 | 19,097 | Brad Thompson | Aaron Cook | Brad Thompson | Aaron Cook | | 194 | 252 | -58 |
| 2007-06-01 | @ HOU | 52 | W 8-1 | 23-29 | 2 | 36,784 | Adam Wainwright | Roy Oswalt | Ryan Franklin | Chad Qualls | | 202 | 253 | -51 |
| 2007-06-02 | @ HOU | 53 | L 3-8 | 23-30 | 3 | 39,234 | Kip Wells | Chris Sampson | Chris Sampson | Kip Wells | | 205 | 261 | -56 |
| 2007-06-03 | @ HOU | 54 | W 8-6 | 24-30 | 2 | 40,483 | Braden Looper | Jason Jennings | Jason Isringhausen | Dan Wheeler | | 213 | 267 | -54 |
| 2007-06-05 | vs CIN | 55 | W 4-3 | 25-30 | 2 | 43,532 | Todd Wellemeyer | Aaron Harang | Jason Isringhausen | Jared Burton | | 217 | 270 | -53 |
| 2007-06-06 | vs CIN | 56 | W 6-4 | 26-30 | 2 | 42,029 | Brad Thompson | Bronson Arroyo | Tyler Johnson | Bronson Arroyo | Jason Isringhausen | 223 | 274 | -51 |
| 2007-06-07 | vs CIN | 57 | L 1-5 | 26-31 | 2 | 43,597 | Adam Wainwright | Kyle Lohse | Kyle Lohse | Adam Wainwright | | 224 | 279 | -55 |
| 2007-06-08 | vs ANA | 58 | L 6-10 | 26-32 | 3 | 44,156 | Kip Wells | Bartolo Colon | Hector Carrasco | Tyler Johnson | | 230 | 289 | -59 |
| 2007-06-09 | vs ANA | 59 | L 3-9 | 26-33 | 3 | 45,392 | Braden Looper | Ervin Santana | Ervin Santana | Braden Looper | | 233 | 298 | -65 |
| 2007-06-10 | vs ANA | 60 | W 9-6 | 27-33 | 2 | 43,612 | Todd Wellemeyer | Jered Weaver | Todd Wellemeyer | Chris Bootcheck | | 242 | 304 | -62 |
| 2007-06-12 | @ KCA | 61 | L 1-8 | 27-34 | 3 | 29,354 | Brad Thompson | Brian Bannister | Brian Bannister | Brad Thompson | | 243 | 312 | -69 |
| 2007-06-13 | @ KCA | 62 | W 7-3 | 28-34 | 3 | 25,555 | Adam Wainwright | Odalis Perez | Adam Wainwright | Odalis Perez | | 250 | 315 | -65 |
| 2007-06-14 | @ KCA | 63 | L 8-17 | 28-35 | 3 | 28,837 | Kip Wells | Scott Elarton | Zack Greinke | Kip Wells | | 258 | 332 | -74 |
| 2007-06-15 | @ OAK | 64 | L 3-14 | 28-36 | 3 | 24,241 | Braden Looper | Dan Haren | Dan Haren | Braden Looper | | 261 | 346 | -85 |
| 2007-06-16 | @ OAK | 65 | W 15-6 | 29-36 | 3 | 28,572 | Todd Wellemeyer | Lenny DiNardo | Russ Springer | Lenny DiNardo | | 276 | 352 | -76 |
| 2007-06-17 | @ OAK | 66 | W 10-6 | 30-36 | 3 | 35,077 | Anthony Reyes | Joe Kennedy | Russ Springer | Colby Lewis | | 286 | 358 | -72 |
| 2007-06-18 | vs KCA | 67 | L 3-5 | 30-37 | 3 | 43,524 | Adam Wainwright | Odalis Perez | Odalis Perez | Adam Wainwright | Octavio Dotel | 289 | 363 | -74 |
| 2007-06-19 | vs KCA | 68 | W 5-1 | 31-37 | 3 | 42,712 | Brad Thompson | Scott Elarton | Brad Thompson | Scott Elarton | | 294 | 364 | -70 |
| 2007-06-20 | vs KCA | 69 | W 7-6 | 32-37 | 2 | 42,623 | Todd Wellemeyer | Gil Meche | Kip Wells | Jorge de la Rosa | | 301 | 370 | -69 |
| 2007-06-22 | vs PHI | 70 | L 0-6 | 32-38 | 3 | 45,360 | Anthony Reyes | Jamie Moyer | Jamie Moyer | Anthony Reyes | | 301 | 376 | -75 |
| 2007-06-23 | vs PHI | 71 | W 8-3 | 33-38 | 3 | 45,336 | Adam Wainwright | Adam Eaton | Adam Wainwright | Adam Eaton | | 309 | 379 | -70 |
| 2007-06-24 | vs PHI | 72 | L 1-5 | 33-39 | 3 | 44,899 | Kip Wells | Cole Hamels | Brian Sanches | Brad Thompson | | 310 | 384 | -74 |
| 2007-06-25 | @ NYN | 73 | L 1-2 | 33-40 | 3 | 40,075 | Mike Maroth | Jorge Sosa | Aaron Heilman | Russ Springer | | 311 | 386 | -75 |
| 2007-06-26 | @ NYN | 74 | W 5-3 | 34-40 | 3 | 40,053 | Todd Wellemeyer | Oliver Perez | Brad Thompson | Scott Schoeneweis | Randy Flores | 316 | 389 | -73 |
| 2007-06-27 | @ NYN | 75 | L 0-2 | 34-41 | 3 | 40,948 | Anthony Reyes | Tom Glavine | Tom Glavine | Anthony Reyes | | 316 | 391 | -75 |
| 2007-06-29 | @ CIN | 76 | W 4-2 | 35-41 | 3 | 35,508 | Brad Thompson | Bronson Arroyo | Troy Percival | Marcus McBeth | Jason Isringhausen | 320 | 393 | -73 |
| 2007-06-30 | @ CIN | 77 | L 1-5 | 35-42 | 3 | 32,538 | Adam Wainwright | Kyle Lohse | Kyle Lohse | Adam Wainwright | | 321 | 398 | -77 |
| 2007-07-01 | @ CIN | 78 | W 11-7 | 36-42 | 3 | 24,126 | Mike Maroth | Homer Bailey | Troy Percival | Homer Bailey | | 332 | 405 | -73 |
| 2007-07-02 | vs ARI | 79 | W 11-3 | 37-42 | 3 | 42,312 | Braden Looper | Brandon Webb | Russ Springer | Brandon Webb | | 343 | 408 | -65 |
| 2007-07-03 | vs ARI | 80 | L 1-7 | 37-43 | 3 | 42,127 | Todd Wellemeyer | Yusmeiro Petit | Yusmeiro Petit | Todd Wellemeyer | | 344 | 415 | -71 |
| 2007-07-04 | vs ARI | 81 | W 5-4 | 38-43 | 3 | 43,538 | Brad Thompson | Livan Hernandez | Ryan Franklin | Brandon Lyon | Jason Isringhausen | 349 | 419 | -70 |
| 2007-07-05 | vs ARI | 82 | W 3-2 | 39-43 | 3 | 42,184 | Adam Wainwright | Doug Davis | Adam Wainwright | Doug Davis | Jason Isringhausen | 352 | 421 | -69 |
| 2007-07-06 | vs SFN | 83 | L 3-4 | 39-44 | 3 | 45,245 | Mike Maroth | Noah Lowry | Noah Lowry | Mike Maroth | Randy Messenger | 355 | 425 | -70 |
| 2007-07-07 | vs SFN | 84 | L 6-7 | 39-45 | 3 | 45,355 | Braden Looper | Tim Lincecum | Tim Lincecum | Braden Looper | Brad Hennessey | 361 | 432 | -71 |
| 2007-07-08 | vs SFN | 85 | W 7-0 | 40-45 | 3 | 44,613 | Todd Wellemeyer | Barry Zito | Todd Wellemeyer | Barry Zito | | 368 | 432 | -64 |
| 2007-07-13 | @ PHI | 86 | L 3-13 | 40-46 | 3 | 43,838 | Kip Wells | Kyle Kendrick | Kyle Kendrick | Kip Wells | | 371 | 445 | -74 |
| 2007-07-14 | @ PHI | 87 | L 4-10 | 40-47 | 3 | 45,050 | Mike Maroth | Cole Hamels | Cole Hamels | Mike Maroth | | 375 | 455 | -80 |
| 2007-07-15 | @ PHI | 88 | W 10-2 | 41-47 | 3 | 44,872 | Adam Wainwright | Adam Eaton | Adam Wainwright | Adam Eaton | | 385 | 457 | -72 |
| 2007-07-16 | @ FLO | 89 | W 5-3 | 42-47 | 3 | 13,827 | Braden Looper | Byung-Hyun Kim | Braden Looper | Byung-Hyun Kim | Jason Isringhausen | 390 | 460 | -70 |
| 2007-07-17 | @ FLO | 90 | L 0-4 | 42-48 | 3 | 12,475 | Brad Thompson | Rick Vanden Hurk | Rick Vanden Hurk | Brad Thompson | | 390 | 464 | -74 |
| 2007-07-18 | @ FLO | 91 | W 6-0 | 43-48 | 3 | 12,819 | Kip Wells | Dontrelle Willis | Kip Wells | Dontrelle Willis | | 396 | 464 | -68 |
| 2007-07-19 | @ ATL | 92 | L 1-10 | 43-49 | 3 | 41,171 | Mike Maroth | Tim Hudson | Tim Hudson | Mike Maroth | | 397 | 474 | -77 |
| 2007-07-20 | @ ATL | 93 | W 4-2 | 44-49 | 3 | 42,712 | Adam Wainwright | Chuck James | Adam Wainwright | Rafael Soriano | Jason Isringhausen | 401 | 476 | -75 |
| 2007-07-21 | @ ATL | 94 | L 6-14 | 44-50 | 3 | 53,953 | Braden Looper | Buddy Carlyle | Buddy Carlyle | Braden Looper | | 407 | 490 | -83 |
| 2007-07-22 | @ ATL | 95 | W 7-2 | 45-50 | 3 | 39,181 | Brad Thompson | Jo-Jo Reyes | Jason Isringhausen | Tyler Yates | | 414 | 492 | -78 |
| 2007-07-24 | vs CHN | 96 | L 3-4 | 45-51 | 3 | 45,436 | Kip Wells | Carlos Zambrano | Carlos Zambrano | Kip Wells | Ryan Dempster | 417 | 496 | -79 |
| 2007-07-25 | vs CHN | 97 | L 1-7 | 45-52 | 3 | 45,316 | Adam Wainwright | Ted Lilly | Ted Lilly | Adam Wainwright | | 418 | 503 | -85 |
| 2007-07-26 | vs CHN | 98 | W 11-1 | 46-52 | 3 | 45,308 | Braden Looper | Jason Marquis | Braden Looper | Jason Marquis | | 429 | 504 | -75 |
| 2007-07-27 | vs MIL | 99 | L 2-12 | 46-53 | 3 | 45,137 | Mike Maroth | Claudio Vargas | Claudio Vargas | Mike Maroth | | 431 | 516 | -85 |
| 2007-07-28 | vs MIL | 100 | W 7-6 | 47-53 | 3 | 45,089 | Brad Thompson | Manny Parra | Russ Springer | Francisco Cordero | | 438 | 522 | -84 |
| 2007-07-28 | vs MIL | 101 | W 5-2 | 47-53 | 3 | 45,829 | Anthony Reyes | Chris Capuano | Anthony Reyes | Chris Capuano | Jason Isringhausen | 443 | 524 | -81 |
| 2007-07-29 | vs MIL | 102 | W 9-5 | 48-53 | 3 | 44,854 | Kip Wells | Yovani Gallardo | Ryan Franklin | Derrick Turnbow | | 452 | 529 | -77 |
| 2007-07-31 | @ PIT | 103 | W 6-4 | 49-53 | 3 | 24,085 | Adam Wainwright | Paul Maholm | Adam Wainwright | Paul Maholm | Jason Isringhausen | 458 | 533 | -75 |
| 2007-08-01 | @ PIT | 104 | L 1-15 | 49-54 | 3 | 17,041 | Braden Looper | Tony Armas | Tony Armas | Braden Looper | | 459 | 548 | -89 |
| 2007-08-02 | @ PIT | 105 | L 4-5 | 49-55 | 3 | 19,132 | Anthony Reyes | Shane Youman | Salomon Torres | Brad Thompson | | 463 | 553 | -90 |
| 2007-08-03 | @ WAS | 106 | L 2-3 | 49-56 | 3 | 27,992 | Kip Wells | Tim Redding | Chad Cordero | Ryan Franklin | | 465 | 556 | -91 |
| 2007-08-04 | @ WAS | 107 | L 1-12 | 49-57 | 3 | 29,252 | Joel Pineiro | Joel Hanrahan | Joel Hanrahan | Joel Pineiro | | 466 | 568 | -102 |
| 2007-08-05 | @ WAS | 108 | L 3-6 | 49-58 | 3 | 33,517 | Adam Wainwright | Matt Chico | Ray King | Ryan Franklin | Chad Cordero | 469 | 574 | -105 |
| 2007-08-06 | vs SDN | 109 | W 10-5 | 50-58 | 3 | 42,743 | Braden Looper | David Wells | Braden Looper | David Wells | | 479 | 579 | -100 |
| 2007-08-07 | vs SDN | 110 | L 0-4 | 50-59 | 3 | 42,846 | Anthony Reyes | Jake Peavy | Jake Peavy | Anthony Reyes | | 479 | 583 | -104 |
| 2007-08-08 | vs SDN | 111 | W 2-1 | 51-59 | 3 | 42,138 | Kip Wells | Greg Maddux | Kip Wells | Greg Maddux | Jason Isringhausen | 481 | 584 | -103 |
| 2007-08-09 | vs SDN | 112 | W 5-0 | 52-59 | 3 | 42,848 | Joel Pineiro | Chris Young | Joel Pineiro | Chris Young | | 486 | 584 | -98 |
| 2007-08-10 | vs LAN | 113 | L 1-2 | 52-60 | 3 | 44,595 | Adam Wainwright | Brad Penny | Joe Beimel | Adam Wainwright | Takashi Saito | 487 | 586 | -99 |
| 2007-08-11 | vs LAN | 114 | W 6-1 | 53-60 | 3 | 44,260 | Braden Looper | Derek Lowe | Braden Looper | Derek Lowe | | 493 | 587 | -94 |
| 2007-08-12 | vs LAN | 115 | W 12-2 | 54-60 | 3 | 45,379 | Anthony Reyes | Mark Hendrickson | Anthony Reyes | Mark Hendrickson | | 505 | 589 | -84 |
| 2007-08-14 | @ MIL | 116 | W 12-4 | 55-60 | 3 | 37,518 | Kip Wells | Chris Capuano | Kip Wells | Chris Capuano | | 517 | 593 | -76 |
| 2007-08-15 | @ MIL | 117 | W 8-3 | 56-60 | 3 | 33,404 | Joel Pineiro | Yovani Gallardo | Joel Pineiro | Yovani Gallardo | | 525 | 596 | -71 |
| 2007-08-16 | @ MIL | 118 | W 8-0 | 57-60 | 3 | 36,062 | Adam Wainwright | David Bush | Adam Wainwright | David Bush | | 533 | 596 | -63 |
| 2007-08-17 | @ CHN | 119 | L 1-2 | 57-61 | 3 | 41,634 | Braden Looper | Rich Hill | Rich Hill | Braden Looper | Ryan Dempster | 534 | 598 | -64 |
| 2007-08-18 | @ CHN | 120 | L 3-5 | 57-62 | 3 | 41,369 | Anthony Reyes | Sean Marshall | Sean Marshall | Anthony Reyes | Ryan Dempster | 537 | 603 | -66 |
| 2007-08-20 | @ CHN | 121 | W 6-4 | 58-62 | 3 | 40,141 | Joel Pineiro | Ted Lilly | Joel Pineiro | Ted Lilly | Jason Isringhausen | 543 | 607 | -64 |
| 2007-08-21 | vs FLO | 122 | W 5-2 | 59-62 | 3 | 42,059 | Adam Wainwright | Daniel Barone | Troy Percival | Armando Benitez | Jason Isringhausen | 548 | 609 | -61 |
| 2007-08-22 | vs FLO | 123 | W 6-4 | 60-62 | 3 | 42,147 | Braden Looper | Scott Olsen | Russ Springer | Scott Olsen | Jason Isringhausen | 554 | 613 | -59 |
| 2007-08-23 | vs FLO | 124 | L 3-11 | 60-63 | 3 | 42,123 | Anthony Reyes | Rick Vanden Hurk | Rick Vanden Hurk | Anthony Reyes | | 557 | 624 | -67 |
| 2007-08-24 | vs ATL | 125 | L 2-7 | 60-64 | 3 | 44,032 | Kip Wells | John Smoltz | John Smoltz | Kip Wells | | 559 | 631 | -72 |
| 2007-08-25 | vs ATL | 126 | W 5-4 | 61-64 | 3 | 45,441 | Joel Pineiro | Tim Hudson | Russ Springer | Tim Hudson | Jason Isringhausen | 564 | 635 | -71 |
| 2007-08-26 | vs ATL | 127 | W 4-1 | 62-64 | 3 | 43,934 | Adam Wainwright | Jo-Jo Reyes | Adam Wainwright | Jo-Jo Reyes | Jason Isringhausen | 568 | 636 | -68 |
| 2007-08-28 | @ HOU | 128 | W 7-0 | 63-64 | 3 | 37,915 | Braden Looper | Woody Williams | Braden Looper | Woody Williams | | 575 | 636 | -61 |
| 2007-08-29 | @ HOU | 129 | L 0-7 | 63-65 | 3 | 33,422 | Kip Wells | Roy Oswalt | Roy Oswalt | Kip Wells | | 575 | 643 | -68 |
| 2007-08-30 | @ HOU | 130 | L 1-2 | 63-66 | 3 | 37,520 | Joel Pineiro | Matt Albers | Matt Albers | Joel Pineiro | Brad Lidge | 576 | 645 | -69 |
| 2007-08-31 | vs CIN | 131 | W 8-5 | 64-66 | 3 | 43,564 | Anthony Reyes | Tom Shearn | Randy Flores | Gary Majewski | | 584 | 650 | -66 |
| 2007-09-01 | vs CIN | 132 | W 11-3 | 65-66 | 3 | 42,356 | Adam Wainwright | Phil Dumatrait | Adam Wainwright | Phil Dumatrait | | 595 | 653 | -58 |
| 2007-09-02 | vs CIN | 133 | W 3-2 | 66-66 | 3 | 44,223 | Braden Looper | Bronson Arroyo | Braden Looper | Bronson Arroyo | Jason Isringhausen | 598 | 655 | -57 |
| 2007-09-03 | vs PIT | 134 | L 0-11 | 66-67 | 3 | 42,238 | Kip Wells | Ian Snell | Ian Snell | Kip Wells | | 598 | 666 | -68 |
| 2007-09-04 | vs PIT | 135 | W 6-2 | 67-67 | 3 | 42,300 | Joel Pineiro | Matt Morris | Joel Pineiro | Matt Morris | Ryan Franklin | 604 | 668 | -64 |
| 2007-09-05 | vs PIT | 136 | L 2-8 | 67-68 | 3 | 42,299 | Mark Mulder | Tony Armas | Tony Armas | Mark Mulder | | 606 | 676 | -70 |
| 2007-09-06 | vs PIT | 137 | W 16-4 | 68-68 | 3 | 42,330 | Mike Maroth | Bryan Bullington | Kelvin Jimenez | Bryan Bullington | | 622 | 680 | -58 |
| 2007-09-07 | @ ARI | 138 | L 2-4 | 68-69 | 3 | 31,225 | Adam Wainwright | Brandon Webb | Brandon Webb | Adam Wainwright | Jose Valverde | 624 | 684 | -60 |
| 2007-09-08 | @ ARI | 139 | L 8-9 | 68-70 | 3 | 45,931 | Braden Looper | Micah Owings | Dana Eveland | Todd Wellemeyer | Jose Valverde | 632 | 693 | -61 |
| 2007-09-09 | @ ARI | 140 | L 5-6 | 68-71 | 3 | 35,136 | Brad Thompson | Doug Davis | Yusmeiro Petit | Ryan Franklin | Jose Valverde | 637 | 699 | -62 |
| 2007-09-10 | @ CHN | 141 | L 3-12 | 68-72 | 3 | 40,358 | Joel Pineiro | Ted Lilly | Ted Lilly | Joel Pineiro | | 640 | 711 | -71 |
| 2007-09-11 | @ CIN | 142 | L 2-7 | 68-73 | 3 | 14,027 | Mark Mulder | Matt Belisle | Matt Belisle | Mark Mulder | | 642 | 718 | -76 |
| 2007-09-12 | @ CIN | 143 | L 1-5 | 68-74 | 3 | 16,167 | Anthony Reyes | Bronson Arroyo | Bronson Arroyo | Anthony Reyes | | 643 | 723 | -80 |
| 2007-09-13 | @ CIN | 144 | L 4-5 | 68-75 | 3 | 18,018 | Kip Wells | Aaron Harang | Aaron Harang | Kip Wells | David Weathers | 647 | 728 | -81 |
| 2007-09-14 | vs CHN | 145 | L 3-5 | 68-76 | 3 | 45,750 | Adam Wainwright | Carlos Zambrano | Carlos Zambrano | Adam Wainwright | Bob Howry | 650 | 733 | -83 |
| 2007-09-15 | vs CHN | 146 | L 2-3 | 69-76 | 3 | 45,918 | Braden Looper | Ted Lilly | Kerry Wood | Ryan Franklin | Ryan Dempster | 652 | 736 | -84 |
| 2007-09-15 | vs CHN | 147 | W 4-3 | 69-76 | 3 | 45,894 | Joel Pineiro | Sean Marshall | Joel Pineiro | Sean Marshall | Jason Isringhausen | 656 | 739 | -83 |
| 2007-09-16 | vs CHN | 148 | L 2-4 | 69-77 | 3 | 45,735 | Mark Mulder | Jason Marquis | Jason Marquis | Mark Mulder | Ryan Dempster | 658 | 743 | -85 |
| 2007-09-17 | vs PHI | 149 | L 11-13 | 69-78 | 3 | 42,031 | Brad Thompson | Kyle Kendrick | Kyle Kendrick | Brad Thompson | Francisco Rosario | 669 | 756 | -87 |
| 2007-09-18 | vs PHI | 150 | L 4-7 | 69-79 | 3 | 42,170 | Todd Wellemeyer | Cole Hamels | Jose Mesa | Mike Maroth | Clay Condrey | 673 | 763 | -90 |
| 2007-09-19 | vs PHI | 151 | W 2-1 | 70-79 | 3 | 44,337 | Adam Wainwright | Jamie Moyer | Randy Flores | Brett Myers | | 675 | 764 | -89 |
| 2007-09-20 | vs HOU | 152 | L 1-18 | 70-80 | 3 | 42,171 | Braden Looper | Wandy Rodriguez | Wandy Rodriguez | Braden Looper | | 676 | 782 | -106 |
| 2007-09-21 | vs HOU | 153 | L 3-6 | 70-81 | 4 | 43,677 | Joel Pineiro | Brandon Backe | Brandon Backe | Joel Pineiro | Brad Lidge | 679 | 788 | -109 |
| 2007-09-22 | vs HOU | 154 | W 7-4 | 71-81 | 3 | 46,237 | Brad Thompson | Matt Albers | Brad Thompson | Matt Albers | Jason Isringhausen | 686 | 792 | -106 |
| 2007-09-23 | vs HOU | 155 | W 4-3 | 72-81 | 3 | 46,169 | Todd Wellemeyer | Roy Oswalt | Kelvin Jimenez | Brad Lidge | | 690 | 795 | -105 |
| 2007-09-24 | @ MIL | 156 | L 5-13 | 72-82 | 3 | 40,908 | Adam Wainwright | David Bush | David Bush | Adam Wainwright | | 695 | 808 | -113 |
| 2007-09-25 | @ MIL | 157 | L 1-9 | 72-83 | 3 | 32,329 | Braden Looper | Jeff Suppan | Jeff Suppan | Braden Looper | | 696 | 817 | -121 |
| 2007-09-26 | @ MIL | 158 | W 7-3 | 73-83 | 3 | 32,411 | Brad Thompson | Carlos Villanueva | Brad Thompson | Carlos Villanueva | | 703 | 820 | -117 |
| 2007-09-27 | @ NYN | 159 | W 3-0 | 74-83 | 3 | 48,900 | Joel Pineiro | Pedro Martinez | Joel Pineiro | Pedro Martinez | Jason Isringhausen | 706 | 820 | -114 |
| 2007-09-28 | @ PIT | 160 | W 6-1 | 75-83 | 3 | 30,603 | Todd Wellemeyer | Zach Duke | Russ Springer | John Grabow | | 712 | 821 | -109 |
| 2007-09-29 | @ PIT | 161 | W 7-3 | 76-83 | 3 | 35,169 | Adam Wainwright | Tom Gorzelanny | Adam Wainwright | Tom Gorzelanny | | 719 | 824 | -105 |
| 2007-09-30 | @ PIT | 162 | W 6-5 | 77-83 | 3 | 25,664 | Troy Percival | Bryan Bullington | Kip Wells | Bryan Bullington | Jason Isringhausen | 725 | 829 | -104 |