| 2007-04-02 | vs OAK | 1 | W 4-0 | 1-0 | 1 | 46,003 | Felix Hernandez | Dan Haren | Felix Hernandez | Dan Haren | | 4 | 0 | 4 |
| 2007-04-03 | vs OAK | 2 | W 8-4 | 2-0 | 1 | 25,287 | Jarrod Washburn | Joe Blanton | Julio Mateo | Kiko Calero | | 12 | 4 | 8 |
| 2007-04-04 | vs OAK | 3 | L 0-9 | 2-1 | 2 | 22,816 | Miguel Batista | Rich Harden | Rich Harden | Miguel Batista | | 12 | 13 | -1 |
| 2007-04-10 | @ BOS | 4 | L 3-14 | 2-2 | 2 | 35,847 | Jeff Weaver | Josh Beckett | Josh Beckett | Jeff Weaver | | 15 | 27 | -12 |
| 2007-04-11 | @ BOS | 5 | W 3-0 | 3-2 | 2 | 36,630 | Felix Hernandez | Daisuke Matsuzaka | Felix Hernandez | Daisuke Matsuzaka | | 18 | 27 | -9 |
| 2007-04-13 | vs TEX | 6 | L 2-5 | 3-3 | 2 | 25,243 | Jarrod Washburn | Kevin Millwood | Kevin Millwood | Jarrod Washburn | Eric Gagne | 20 | 32 | -12 |
| 2007-04-14 | vs TEX | 7 | W 8-3 | 4-3 | 1 | 25,954 | Miguel Batista | Vicente Padilla | Miguel Batista | Vicente Padilla | | 28 | 35 | -7 |
| 2007-04-15 | vs TEX | 8 | W 14-6 | 5-3 | 1 | 25,001 | Horacio Ramirez | Brandon McCarthy | Horacio Ramirez | Brandon McCarthy | | 42 | 41 | 1 |
| 2007-04-17 | vs MIN | 9 | L 2-11 | 5-4 | 1 | 19,015 | Jeff Weaver | Ramon Ortiz | Ramon Ortiz | Jeff Weaver | | 44 | 52 | -8 |
| 2007-04-18 | vs MIN | 10 | L 4-5 | 5-5 | 2 | 20,871 | Felix Hernandez | Carlos Silva | Carlos Silva | Felix Hernandez | Joe Nathan | 48 | 57 | -9 |
| 2007-04-19 | vs MIN | 11 | L 5-6 | 5-6 | 2 | 19,350 | Jarrod Washburn | Johan Santana | Johan Santana | Jarrod Washburn | Joe Nathan | 53 | 63 | -10 |
| 2007-04-20 | @ ANA | 12 | L 4-8 | 5-7 | 3 | 43,359 | Miguel Batista | Joe Saunders | Joe Saunders | Miguel Batista | Francisco Rodriguez | 57 | 71 | -14 |
| 2007-04-21 | @ ANA | 13 | L 6-7 | 5-8 | 4 | 43,752 | Horacio Ramirez | Bartolo Colon | Bartolo Colon | Horacio Ramirez | Francisco Rodriguez | 63 | 78 | -15 |
| 2007-04-22 | @ ANA | 14 | L 1-6 | 5-9 | 4 | 43,628 | Jeff Weaver | Ervin Santana | Ervin Santana | Jeff Weaver | | 64 | 84 | -20 |
| 2007-04-23 | @ TEX | 15 | W 5-4 | 6-9 | 4 | 26,592 | Cha-Seung Baek | Kevin Millwood | Brandon Morrow | Kevin Millwood | J.J. Putz | 69 | 88 | -19 |
| 2007-04-25 | @ OAK | 16 | W 2-0 | 7-9 | 3 | 19,674 | Jarrod Washburn | Joe Blanton | Jarrod Washburn | Joe Blanton | | 71 | 88 | -17 |
| 2007-04-26 | @ OAK | 17 | W 4-2 | 8-9 | 3 | 14,683 | Miguel Batista | Joe Kennedy | Miguel Batista | Kiko Calero | J.J. Putz | 75 | 90 | -15 |
| 2007-04-27 | vs KCA | 18 | W 7-4 | 9-9 | 2 | 37,281 | Horacio Ramirez | Jorge de la Rosa | Horacio Ramirez | Jorge de la Rosa | J.J. Putz | 82 | 94 | -12 |
| 2007-04-28 | vs KCA | 19 | L 3-8 | 9-10 | 3 | 32,441 | Jeff Weaver | Gil Meche | Gil Meche | Jeff Weaver | Brandon Duckworth | 85 | 102 | -17 |
| 2007-04-29 | vs KCA | 20 | W 5-1 | 10-10 | 2 | 26,019 | Cha-Seung Baek | Brian Bannister | Brandon Morrow | Brian Bannister | | 90 | 103 | -13 |
| 2007-05-01 | vs CHA | 21 | W 5-2 | 11-10 | 2 | 20,739 | Jarrod Washburn | Javier Vazquez | Jarrod Washburn | Javier Vazquez | J.J. Putz | 95 | 105 | -10 |
| 2007-05-02 | vs CHA | 22 | W 3-2 | 12-10 | 2 | 16,555 | Miguel Batista | John Danks | Miguel Batista | John Danks | J.J. Putz | 98 | 107 | -9 |
| 2007-05-03 | @ BOS | 23 | L 7-8 | 12-11 | 2 | 37,216 | Horacio Ramirez | Daisuke Matsuzaka | Brendan Donnelly | Chris Reitsma | J.C. Romero | 105 | 115 | -10 |
| 2007-05-04 | @ NYA | 24 | W 15-11 | 13-11 | 2 | 49,519 | Cha-Seung Baek | Kei Igawa | Eric O'Flaherty | Colter Bean | J.J. Putz | 120 | 126 | -6 |
| 2007-05-05 | @ NYA | 25 | L 1-8 | 13-12 | 2 | 51,702 | Jeff Weaver | Chien-Ming Wang | Chien-Ming Wang | Jeff Weaver | | 121 | 134 | -13 |
| 2007-05-06 | @ NYA | 26 | L 0-5 | 13-13 | 3 | 52,553 | Jarrod Washburn | Darrell Rasner | Darrell Rasner | Jarrod Washburn | | 121 | 139 | -18 |
| 2007-05-07 | @ NYA | 27 | W 3-2 | 14-13 | 2 | 47,424 | Miguel Batista | Matt DeSalvo | George Sherrill | Mariano Rivera | J.J. Putz | 124 | 141 | -17 |
| 2007-05-08 | @ DET | 28 | L 7-9 | 14-14 | 3 | 30,171 | Horacio Ramirez | Jeremy Bonderman | Jeremy Bonderman | Horacio Ramirez | Todd Jones | 131 | 150 | -19 |
| 2007-05-09 | @ DET | 29 | W 9-2 | 15-14 | 2 | 27,377 | Cha-Seung Baek | Nate Robertson | Cha-Seung Baek | Nate Robertson | | 140 | 152 | -12 |
| 2007-05-10 | @ DET | 30 | L 3-7 | 15-15 | 3 | 37,359 | Jeff Weaver | Justin Verlander | Justin Verlander | Jeff Weaver | | 143 | 159 | -16 |
| 2007-05-11 | vs NYA | 31 | W 3-0 | 16-15 | 3 | 44,214 | Jarrod Washburn | Darrell Rasner | Jarrod Washburn | Darrell Rasner | J.J. Putz | 146 | 159 | -13 |
| 2007-05-12 | vs NYA | 32 | L 2-7 | 16-16 | 3 | 46,153 | Miguel Batista | Matt DeSalvo | Matt DeSalvo | Miguel Batista | | 148 | 166 | -18 |
| 2007-05-13 | vs NYA | 33 | W 2-1 | 17-16 | 3 | 46,181 | Horacio Ramirez | Andy Pettitte | Horacio Ramirez | Andy Pettitte | J.J. Putz | 150 | 167 | -17 |
| 2007-05-15 | vs ANA | 34 | W 11-3 | 18-16 | 2 | 21,769 | Felix Hernandez | Kelvim Escobar | Sean White | Kelvim Escobar | | 161 | 170 | -9 |
| 2007-05-16 | vs ANA | 35 | L 0-5 | 18-17 | 2 | 22,331 | Cha-Seung Baek | John Lackey | John Lackey | Cha-Seung Baek | | 161 | 175 | -14 |
| 2007-05-17 | vs ANA | 36 | L 3-7 | 18-18 | 3 | 20,488 | Jarrod Washburn | Bartolo Colon | Bartolo Colon | Jarrod Washburn | | 164 | 182 | -18 |
| 2007-05-18 | vs SDN | 37 | L 1-8 | 18-19 | 3 | 39,531 | Miguel Batista | Chris Young | Chris Young | Miguel Batista | | 165 | 190 | -25 |
| 2007-05-19 | vs SDN | 38 | W 7-4 | 19-19 | 3 | 34,287 | Horacio Ramirez | Greg Maddux | Horacio Ramirez | Greg Maddux | J.J. Putz | 172 | 194 | -22 |
| 2007-05-20 | vs SDN | 39 | L 1-2 | 19-20 | 3 | 38,844 | Felix Hernandez | Justin Germano | Justin Germano | Felix Hernandez | Trevor Hoffman | 173 | 196 | -23 |
| 2007-05-21 | @ CLE | 40 | L 2-5 | 19-21 | 3 | 38,645 | Cha-Seung Baek | CC Sabathia | Tom Mastny | Cha-Seung Baek | Joe Borowski | 175 | 201 | -26 |
| 2007-05-22 | @ TBA | 41 | W 5-2 | 20-21 | 3 | 9,254 | Jarrod Washburn | Scott Kazmir | Jarrod Washburn | Chad Orvella | J.J. Putz | 180 | 203 | -23 |
| 2007-05-23 | @ TBA | 42 | W 5-1 | 21-21 | 3 | 8,440 | Miguel Batista | Casey Fossum | Miguel Batista | Casey Fossum | | 185 | 204 | -19 |
| 2007-05-24 | @ TBA | 43 | L 12-13 | 21-22 | 3 | 9,149 | Horacio Ramirez | Jae Weong Seo | Jae Weong Seo | Sean White | Alberto Reyes | 197 | 217 | -20 |
| 2007-05-25 | @ KCA | 44 | W 10-2 | 22-22 | 3 | 28,651 | Felix Hernandez | Gil Meche | Felix Hernandez | Gil Meche | | 207 | 219 | -12 |
| 2007-05-26 | @ KCA | 45 | W 9-1 | 23-22 | 2 | 21,138 | Cha-Seung Baek | Brian Bannister | Cha-Seung Baek | Brian Bannister | | 216 | 220 | -4 |
| 2007-05-27 | @ KCA | 46 | W 7-4 | 24-22 | 2 | 16,091 | Jarrod Washburn | Odalis Perez | Jarrod Washburn | Odalis Perez | J.J. Putz | 223 | 224 | -1 |
| 2007-05-28 | @ ANA | 47 | W 12-5 | 25-22 | 2 | 42,352 | Miguel Batista | Bartolo Colon | Miguel Batista | Bartolo Colon | | 235 | 229 | 6 |
| 2007-05-29 | @ ANA | 48 | L 1-4 | 25-23 | 2 | 38,174 | Ryan Feierabend | Ervin Santana | Ervin Santana | Ryan Feierabend | Francisco Rodriguez | 236 | 233 | 3 |
| 2007-05-30 | @ ANA | 49 | L 6-8 | 25-24 | 2 | 39,288 | Felix Hernandez | Jered Weaver | Dustin Moseley | Felix Hernandez | Francisco Rodriguez | 242 | 241 | 1 |
| 2007-05-31 | vs TEX | 50 | W 9-5 | 26-24 | 2 | 20,137 | Cha-Seung Baek | Vicente Padilla | Cha-Seung Baek | Vicente Padilla | | 251 | 246 | 5 |
| 2007-06-01 | vs TEX | 51 | L 8-9 | 26-25 | 2 | 34,570 | Jarrod Washburn | Kevin Millwood | Joaquin Benoit | Sean Green | Eric Gagne | 259 | 255 | 4 |
| 2007-06-02 | vs TEX | 52 | W 5-4 | 27-25 | 2 | 41,988 | Miguel Batista | Kameron Loe | Miguel Batista | Kameron Loe | J.J. Putz | 264 | 259 | 5 |
| 2007-06-03 | vs TEX | 53 | W 11-6 | 28-25 | 2 | 36,886 | Ryan Feierabend | Rob Tejeda | Ryan Feierabend | Rob Tejeda | | 275 | 265 | 10 |
| 2007-06-04 | vs BAL | 54 | W 7-4 | 29-25 | 2 | 19,090 | Felix Hernandez | Erik Bedard | George Sherrill | Chad Bradford | J.J. Putz | 282 | 269 | 13 |
| 2007-06-05 | vs BAL | 55 | W 5-4 | 30-25 | 2 | 19,287 | Cha-Seung Baek | Brian Burres | Jason Davis | Jamie Walker | J.J. Putz | 287 | 273 | 14 |
| 2007-06-06 | vs BAL | 56 | L 5-9 | 30-26 | 2 | 29,010 | Jarrod Washburn | Daniel Cabrera | Daniel Cabrera | Jarrod Washburn | | 292 | 282 | 10 |
| 2007-06-08 | @ SDN | 57 | W 6-5 | 31-26 | 2 | 44,325 | Miguel Batista | Justin Germano | Eric O'Flaherty | Cla Meredith | J.J. Putz | 298 | 287 | 11 |
| 2007-06-09 | @ SDN | 58 | W 6-5 | 32-26 | 2 | 37,178 | Jeff Weaver | David Wells | Sean Green | Doug Brocail | J.J. Putz | 304 | 292 | 12 |
| 2007-06-10 | @ SDN | 59 | W 4-3 | 33-26 | 2 | 35,950 | Felix Hernandez | Chris Young | Miguel Batista | Trevor Hoffman | J.J. Putz | 308 | 295 | 13 |
| 2007-06-11 | @ CLE | 60 | W 8-7 | 34-26 | 2 | 22,325 | Cha-Seung Baek | Paul Byrd | Brandon Morrow | Joe Borowski | | 316 | 302 | 14 |
| 2007-06-12 | @ CHN | 61 | W 5-3 | 35-26 | 2 | 40,071 | Jarrod Washburn | Rich Hill | Eric O'Flaherty | Will Ohman | J.J. Putz | 321 | 305 | 16 |
| 2007-06-13 | @ CHN | 62 | L 2-3 | 35-27 | 2 | 40,163 | Miguel Batista | Sean Marshall | Sean Marshall | Miguel Batista | Ryan Dempster | 323 | 308 | 15 |
| 2007-06-14 | @ CHN | 63 | L 4-5 | 35-28 | 2 | 39,846 | Jeff Weaver | Jason Marquis | Bob Howry | Brandon Morrow | | 327 | 313 | 14 |
| 2007-06-15 | @ HOU | 64 | L 1-5 | 35-29 | 3 | 37,322 | Felix Hernandez | Wandy Rodriguez | Wandy Rodriguez | Felix Hernandez | | 328 | 318 | 10 |
| 2007-06-16 | @ HOU | 65 | L 4-9 | 35-30 | 3 | 41,974 | Cha-Seung Baek | Woody Williams | Woody Williams | Cha-Seung Baek | | 332 | 327 | 5 |
| 2007-06-17 | @ HOU | 66 | L 3-10 | 35-31 | 3 | 42,019 | Jarrod Washburn | Roy Oswalt | Roy Oswalt | Jarrod Washburn | | 335 | 337 | -2 |
| 2007-06-19 | vs PIT | 67 | L 3-5 | 35-32 | 3 | 24,520 | Miguel Batista | Tom Gorzelanny | Tom Gorzelanny | Miguel Batista | Shawn Chacon | 338 | 342 | -4 |
| 2007-06-20 | vs PIT | 68 | W 7-0 | 36-32 | 3 | 23,553 | Jeff Weaver | Paul Maholm | Jeff Weaver | Paul Maholm | | 345 | 342 | 3 |
| 2007-06-21 | vs PIT | 69 | W 3-0 | 37-32 | 3 | 22,950 | Felix Hernandez | John Van Benschoten | Felix Hernandez | John Van Benschoten | J.J. Putz | 348 | 342 | 6 |
| 2007-06-22 | vs CIN | 70 | L 1-16 | 37-33 | 3 | 46,340 | Ryan Feierabend | Aaron Harang | Aaron Harang | Ryan Feierabend | | 349 | 358 | -9 |
| 2007-06-23 | vs CIN | 71 | W 9-1 | 38-33 | 2 | 45,939 | Jarrod Washburn | Kyle Lohse | Jarrod Washburn | Kyle Lohse | | 358 | 359 | -1 |
| 2007-06-24 | vs CIN | 72 | W 3-2 | 39-33 | 2 | 46,064 | Miguel Batista | Bronson Arroyo | Eric O'Flaherty | Bronson Arroyo | J.J. Putz | 361 | 361 | 0 |
| 2007-06-25 | vs BOS | 73 | W 9-4 | 40-33 | 2 | 33,830 | Jeff Weaver | Julian Tavarez | Jeff Weaver | Julian Tavarez | | 370 | 365 | 5 |
| 2007-06-26 | vs BOS | 74 | W 8-7 | 41-33 | 2 | 35,045 | Felix Hernandez | Kason Gabbard | Eric O'Flaherty | Javier Lopez | J.J. Putz | 378 | 372 | 6 |
| 2007-06-27 | vs BOS | 75 | W 2-1 | 42-33 | 2 | 43,448 | Ryan Feierabend | Daisuke Matsuzaka | Jason Davis | Joel Pineiro | | 380 | 373 | 7 |
| 2007-06-29 | vs TOR | 76 | W 5-3 | 43-33 | 2 | 41,862 | Jarrod Washburn | Dustin McGowan | Jarrod Washburn | Dustin McGowan | J.J. Putz | 385 | 376 | 9 |
| 2007-06-30 | vs TOR | 77 | W 8-3 | 44-33 | 2 | 36,102 | Miguel Batista | Roy Halladay | Miguel Batista | Roy Halladay | | 393 | 379 | 14 |
| 2007-07-01 | vs TOR | 78 | W 2-1 | 45-33 | 2 | 38,778 | Jeff Weaver | Shaun Marcum | J.J. Putz | Jeremy Accardo | | 395 | 380 | 15 |
| 2007-07-02 | @ KCA | 79 | L 2-3 | 45-34 | 2 | 13,257 | Felix Hernandez | Gil Meche | Octavio Dotel | Brandon Morrow | | 397 | 383 | 14 |
| 2007-07-03 | @ KCA | 80 | L 3-17 | 45-35 | 2 | 28,140 | Ryan Feierabend | Jorge de la Rosa | Jorge de la Rosa | Ryan Feierabend | | 400 | 400 | 0 |
| 2007-07-04 | @ KCA | 81 | W 4-0 | 46-35 | 2 | 27,497 | Jarrod Washburn | Brian Bannister | Jarrod Washburn | Brian Bannister | J.J. Putz | 404 | 400 | 4 |
| 2007-07-05 | @ OAK | 82 | L 2-3 | 46-36 | 2 | 15,654 | Miguel Batista | Chad Gaudin | Chad Gaudin | Miguel Batista | Alan Embree | 406 | 403 | 3 |
| 2007-07-06 | @ OAK | 83 | W 7-1 | 47-36 | 2 | 19,158 | Jeff Weaver | Dan Haren | Eric O'Flaherty | Dan Haren | | 413 | 404 | 9 |
| 2007-07-07 | @ OAK | 84 | W 4-0 | 48-36 | 2 | 29,225 | Felix Hernandez | Rich Harden | Felix Hernandez | Rich Harden | | 417 | 404 | 13 |
| 2007-07-08 | @ OAK | 85 | W 7-3 | 49-36 | 2 | 27,059 | Ryan Feierabend | Joe Blanton | Sean Green | Joe Blanton | | 424 | 407 | 17 |
| 2007-07-12 | vs DET | 86 | W 3-2 | 50-36 | 2 | 31,994 | Felix Hernandez | Andrew Miller | Felix Hernandez | Andrew Miller | J.J. Putz | 427 | 409 | 18 |
| 2007-07-13 | vs DET | 87 | L 3-6 | 50-37 | 2 | 37,393 | Jarrod Washburn | Jeremy Bonderman | Jeremy Bonderman | Jarrod Washburn | Todd Jones | 430 | 415 | 15 |
| 2007-07-14 | vs DET | 88 | W 6-4 | 51-37 | 2 | 38,202 | Miguel Batista | Kenny Rogers | Miguel Batista | Kenny Rogers | J.J. Putz | 436 | 419 | 17 |
| 2007-07-15 | vs DET | 89 | L 7-11 | 51-38 | 2 | 39,073 | Jeff Weaver | Justin Verlander | Justin Verlander | Jeff Weaver | | 443 | 430 | 13 |
| 2007-07-16 | vs BAL | 90 | W 4-2 | 52-38 | 2 | 23,128 | Horacio Ramirez | Brian Burres | Horacio Ramirez | Brian Burres | J.J. Putz | 447 | 432 | 15 |
| 2007-07-17 | vs BAL | 91 | L 3-8 | 52-39 | 2 | 22,470 | Felix Hernandez | Jeremy Guthrie | Jeremy Guthrie | Felix Hernandez | | 450 | 440 | 10 |
| 2007-07-18 | vs BAL | 92 | W 6-5 | 53-39 | 2 | 28,550 | Jarrod Washburn | Daniel Cabrera | Sean Green | Danys Baez | J.J. Putz | 456 | 445 | 11 |
| 2007-07-20 | @ TOR | 93 | W 4-2 | 54-39 | 2 | 27,079 | Miguel Batista | Jesse Litsch | Miguel Batista | Jesse Litsch | J.J. Putz | 460 | 447 | 13 |
| 2007-07-21 | @ TOR | 94 | L 0-1 | 54-40 | 2 | 28,921 | Jeff Weaver | Josh Towers | Josh Towers | Jeff Weaver | Jeremy Accardo | 460 | 448 | 12 |
| 2007-07-22 | @ TOR | 95 | L 0-8 | 54-41 | 2 | 29,083 | Felix Hernandez | Roy Halladay | Roy Halladay | Felix Hernandez | | 460 | 456 | 4 |
| 2007-07-23 | @ TEX | 96 | L 7-8 | 54-42 | 2 | 20,584 | Horacio Ramirez | Kevin Millwood | Kevin Millwood | Horacio Ramirez | | 467 | 464 | 3 |
| 2007-07-24 | @ TEX | 97 | L 1-2 | 54-43 | 2 | 0 | Ryan Feierabend | John Rheinecker | John Rheinecker | Ryan Feierabend | Eric Gagne | 468 | 466 | 2 |
| 2007-07-24 | @ TEX | 98 | L 3-4 | 54-43 | 2 | 26,842 | Jarrod Washburn | Kameron Loe | C.J. Wilson | Chris Reitsma | Eric Gagne | 471 | 470 | 1 |
| 2007-07-25 | @ TEX | 99 | L 6-7 | 54-44 | 2 | 34,853 | Miguel Batista | Brandon McCarthy | Joaquin Benoit | J.J. Putz | | 477 | 477 | 0 |
| 2007-07-26 | vs OAK | 100 | L 2-6 | 54-45 | 2 | 34,250 | Jeff Weaver | Dan Haren | Dan Haren | Jeff Weaver | | 479 | 483 | -4 |
| 2007-07-27 | vs OAK | 101 | W 7-1 | 55-45 | 2 | 37,643 | Felix Hernandez | Dallas Braden | Felix Hernandez | Dallas Braden | | 486 | 484 | 2 |
| 2007-07-28 | vs OAK | 102 | W 4-3 | 56-45 | 2 | 41,260 | Horacio Ramirez | Chad Gaudin | Horacio Ramirez | Chad Gaudin | J.J. Putz | 490 | 487 | 3 |
| 2007-07-29 | vs OAK | 103 | W 14-10 | 57-45 | 2 | 41,961 | Jarrod Washburn | Lenny DiNardo | Sean Green | Huston Street | | 504 | 497 | 7 |
| 2007-07-30 | vs ANA | 104 | W 2-0 | 58-45 | 2 | 31,232 | Miguel Batista | Kelvim Escobar | Miguel Batista | Kelvim Escobar | J.J. Putz | 506 | 497 | 9 |
| 2007-07-31 | vs ANA | 105 | L 0-8 | 58-46 | 2 | 28,903 | Jeff Weaver | John Lackey | John Lackey | Jeff Weaver | | 506 | 505 | 1 |
| 2007-08-01 | vs ANA | 106 | W 8-7 | 59-46 | 2 | 34,471 | Felix Hernandez | Jered Weaver | Eric O'Flaherty | Justin Speier | | 514 | 512 | 2 |
| 2007-08-03 | vs BOS | 107 | W 7-4 | 60-46 | 2 | 46,235 | Horacio Ramirez | Jon Lester | Sean Green | Mike Timlin | J.J. Putz | 521 | 516 | 5 |
| 2007-08-04 | vs BOS | 108 | L 3-4 | 60-47 | 2 | 46,313 | Jarrod Washburn | Daisuke Matsuzaka | Daisuke Matsuzaka | Jarrod Washburn | Jonathan Papelbon | 524 | 520 | 4 |
| 2007-08-05 | vs BOS | 109 | L 2-9 | 60-48 | 2 | 46,377 | Miguel Batista | Josh Beckett | Josh Beckett | Miguel Batista | | 526 | 529 | -3 |
| 2007-08-07 | @ BAL | 110 | W 10-3 | 61-48 | 2 | 25,060 | Jeff Weaver | Steve Trachsel | Jeff Weaver | Jamie Walker | | 536 | 532 | 4 |
| 2007-08-08 | @ BAL | 111 | W 8-4 | 62-48 | 2 | 17,511 | Felix Hernandez | Jeremy Guthrie | Felix Hernandez | Jeremy Guthrie | J.J. Putz | 544 | 536 | 8 |
| 2007-08-09 | @ BAL | 112 | W 13-8 | 63-48 | 2 | 18,679 | Horacio Ramirez | Daniel Cabrera | Horacio Ramirez | Daniel Cabrera | George Sherrill | 557 | 544 | 13 |
| 2007-08-10 | @ CHA | 113 | L 3-5 | 63-49 | 2 | 38,586 | Jarrod Washburn | Javier Vazquez | Javier Vazquez | Jarrod Washburn | Bobby Jenks | 560 | 549 | 11 |
| 2007-08-11 | @ CHA | 114 | W 7-6 | 64-49 | 2 | 38,210 | Miguel Batista | Gavin Floyd | Miguel Batista | Gavin Floyd | J.J. Putz | 567 | 555 | 12 |
| 2007-08-12 | @ CHA | 115 | W 6-0 | 65-49 | 2 | 36,629 | Jeff Weaver | John Danks | Jeff Weaver | John Danks | | 573 | 555 | 18 |
| 2007-08-13 | vs MIN | 116 | W 4-3 | 66-49 | 2 | 37,902 | Felix Hernandez | Johan Santana | J.J. Putz | Matt Guerrier | | 577 | 558 | 19 |
| 2007-08-14 | vs MIN | 117 | L 3-11 | 66-50 | 2 | 33,729 | Horacio Ramirez | Matt Garza | Matt Garza | Horacio Ramirez | | 580 | 569 | 11 |
| 2007-08-15 | vs MIN | 118 | L 1-6 | 66-51 | 2 | 42,921 | Jarrod Washburn | Scott Baker | Pat Neshek | Jarrod Washburn | | 581 | 575 | 6 |
| 2007-08-17 | vs CHA | 119 | W 5-4 | 67-51 | 2 | 46,170 | Miguel Batista | Jose Contreras | Miguel Batista | Jose Contreras | J.J. Putz | 586 | 579 | 7 |
| 2007-08-18 | vs CHA | 120 | W 7-5 | 68-51 | 2 | 41,121 | Jeff Weaver | John Danks | Jeff Weaver | John Danks | J.J. Putz | 593 | 584 | 9 |
| 2007-08-19 | vs CHA | 121 | W 11-5 | 69-51 | 2 | 45,668 | Felix Hernandez | Jon Garland | Felix Hernandez | Jon Garland | | 604 | 589 | 15 |
| 2007-08-20 | @ MIN | 122 | W 9-4 | 70-51 | 2 | 31,755 | Horacio Ramirez | Matt Garza | Horacio Ramirez | Matt Garza | | 613 | 593 | 20 |
| 2007-08-21 | @ MIN | 123 | W 7-2 | 71-51 | 2 | 42,373 | Jarrod Washburn | Scott Baker | Jarrod Washburn | Scott Baker | | 620 | 595 | 25 |
| 2007-08-22 | @ MIN | 124 | L 4-8 | 71-52 | 2 | 29,881 | Miguel Batista | Carlos Silva | Carlos Silva | Miguel Batista | | 624 | 603 | 21 |
| 2007-08-23 | @ TEX | 125 | W 9-4 | 72-52 | 2 | 26,963 | Jeff Weaver | Kameron Loe | Jeff Weaver | Kameron Loe | | 633 | 607 | 26 |
| 2007-08-24 | @ TEX | 126 | W 4-2 | 73-52 | 2 | 32,716 | Felix Hernandez | Kevin Millwood | Felix Hernandez | Kevin Millwood | J.J. Putz | 637 | 609 | 28 |
| 2007-08-25 | @ TEX | 127 | L 3-5 | 73-53 | 2 | 47,977 | Horacio Ramirez | Jamey Wright | Joaquin Benoit | Rick White | C.J. Wilson | 640 | 614 | 26 |
| 2007-08-26 | @ TEX | 128 | L 3-5 | 73-54 | 2 | 25,437 | Jarrod Washburn | Vicente Padilla | Vicente Padilla | Jarrod Washburn | | 643 | 619 | 24 |
| 2007-08-27 | vs ANA | 129 | L 0-6 | 73-55 | 2 | 45,998 | Miguel Batista | John Lackey | John Lackey | Miguel Batista | | 643 | 625 | 18 |
| 2007-08-28 | vs ANA | 130 | L 6-10 | 73-56 | 2 | 44,395 | Jeff Weaver | Ervin Santana | Justin Speier | Brandon Morrow | | 649 | 635 | 14 |
| 2007-08-29 | vs ANA | 131 | L 2-8 | 73-57 | 2 | 46,047 | Felix Hernandez | Jered Weaver | Jered Weaver | Felix Hernandez | | 651 | 643 | 8 |
| 2007-08-30 | @ CLE | 132 | L 5-6 | 73-58 | 2 | 25,949 | Horacio Ramirez | Aaron Laffey | Joe Borowski | Eric O'Flaherty | | 656 | 649 | 7 |
| 2007-08-31 | @ TOR | 133 | L 5-7 | 73-59 | 2 | 34,518 | Jarrod Washburn | Shaun Marcum | Shaun Marcum | Jarrod Washburn | Jeremy Accardo | 661 | 656 | 5 |
| 2007-09-01 | @ TOR | 134 | L 1-2 | 73-60 | 2 | 30,672 | Miguel Batista | Dustin McGowan | Dustin McGowan | Sean Green | Jeremy Accardo | 662 | 658 | 4 |
| 2007-09-02 | @ TOR | 135 | L 4-6 | 73-61 | 2 | 32,166 | Jeff Weaver | A.J. Burnett | A.J. Burnett | Jeff Weaver | Casey Janssen | 666 | 664 | 2 |
| 2007-09-03 | @ NYA | 136 | W 7-1 | 74-61 | 2 | 54,522 | Felix Hernandez | Roger Clemens | Felix Hernandez | Roger Clemens | | 673 | 665 | 8 |
| 2007-09-04 | @ NYA | 137 | L 3-12 | 74-62 | 2 | 52,487 | Horacio Ramirez | Chien-Ming Wang | Chien-Ming Wang | Horacio Ramirez | | 676 | 677 | -1 |
| 2007-09-05 | @ NYA | 138 | L 2-10 | 74-63 | 2 | 52,538 | Jarrod Washburn | Phil Hughes | Joba Chamberlain | Jarrod Washburn | | 678 | 687 | -9 |
| 2007-09-07 | @ DET | 139 | L 1-6 | 74-64 | 2 | 39,750 | Miguel Batista | Justin Verlander | Justin Verlander | Miguel Batista | | 679 | 693 | -14 |
| 2007-09-08 | @ DET | 140 | L 6-12 | 74-65 | 2 | 42,184 | Jeff Weaver | Nate Robertson | Zach Miner | Jeff Weaver | | 685 | 705 | -20 |
| 2007-09-09 | @ DET | 141 | W 14-7 | 75-65 | 2 | 39,990 | Felix Hernandez | Jeremy Bonderman | Felix Hernandez | Jeremy Bonderman | | 699 | 712 | -13 |
| 2007-09-10 | vs OAK | 142 | L 3-9 | 75-66 | 2 | 26,698 | Horacio Ramirez | Joe Blanton | Joe Blanton | Horacio Ramirez | Huston Street | 702 | 721 | -19 |
| 2007-09-11 | vs OAK | 143 | L 4-7 | 75-67 | 2 | 26,676 | Jarrod Washburn | Dallas Braden | Ruddy Lugo | Jarrod Washburn | Huston Street | 706 | 728 | -22 |
| 2007-09-12 | vs OAK | 144 | W 6-5 | 76-67 | 2 | 26,194 | Miguel Batista | Dan Haren | J.J. Putz | Andrew Brown | | 712 | 733 | -21 |
| 2007-09-13 | vs TBA | 145 | W 8-7 | 77-67 | 2 | 23,991 | Jeff Weaver | Jason Hammel | Ryan Rowland-Smith | Dan Wheeler | J.J. Putz | 720 | 740 | -20 |
| 2007-09-14 | vs TBA | 146 | W 2-1 | 78-67 | 2 | 30,164 | Felix Hernandez | James Shields | J.J. Putz | Gary Glover | | 722 | 741 | -19 |
| 2007-09-15 | vs TBA | 147 | L 2-6 | 78-68 | 2 | 33,793 | Horacio Ramirez | Scott Kazmir | Scott Kazmir | Horacio Ramirez | | 724 | 747 | -23 |
| 2007-09-16 | vs TBA | 148 | L 2-9 | 78-69 | 2 | 36,234 | Jarrod Washburn | Andy Sonnanstine | Andy Sonnanstine | Jarrod Washburn | | 726 | 756 | -30 |
| 2007-09-17 | @ OAK | 149 | W 4-0 | 79-69 | 2 | 17,228 | Miguel Batista | Dan Haren | Miguel Batista | Dan Haren | | 730 | 756 | -26 |
| 2007-09-18 | @ OAK | 150 | W 8-7 | 80-69 | 2 | 18,145 | Jeff Weaver | Chad Gaudin | Jeff Weaver | Chad Gaudin | George Sherrill | 738 | 763 | -25 |
| 2007-09-19 | @ OAK | 151 | W 9-5 | 81-69 | 2 | 21,171 | Felix Hernandez | Dan Meyer | Felix Hernandez | Dan Meyer | | 747 | 768 | -21 |
| 2007-09-20 | @ ANA | 152 | L 5-9 | 81-70 | 2 | 40,016 | Ryan Feierabend | Jered Weaver | Jered Weaver | Ryan Feierabend | | 752 | 777 | -25 |
| 2007-09-21 | @ ANA | 153 | W 6-0 | 82-70 | 2 | 44,018 | Jarrod Washburn | Joe Saunders | Jarrod Washburn | Joe Saunders | | 758 | 777 | -19 |
| 2007-09-22 | @ ANA | 154 | W 3-2 | 83-70 | 2 | 43,583 | Miguel Batista | Bartolo Colon | Miguel Batista | Bartolo Colon | J.J. Putz | 761 | 779 | -18 |
| 2007-09-23 | @ ANA | 155 | L 4-7 | 83-71 | 2 | 44,234 | Jeff Weaver | John Lackey | John Lackey | Jeff Weaver | Francisco Rodriguez | 765 | 786 | -21 |
| 2007-09-25 | vs CLE | 156 | L 3-4 | 83-72 | 2 | 22,200 | Felix Hernandez | Aaron Laffey | Tom Mastny | Brandon Morrow | Rafael Betancourt | 768 | 790 | -22 |
| 2007-09-26 | vs CLE | 157 | L 4-12 | 84-72 | 2 | 0 | Ryan Feierabend | Fausto Carmona | Fausto Carmona | Ryan Feierabend | | 772 | 802 | -30 |
| 2007-09-26 | vs CLE | 158 | W 3-2 | 84-72 | 2 | 26,801 | Jarrod Washburn | Jeremy Sowers | J.J. Putz | Aaron Fultz | | 775 | 804 | -29 |
| 2007-09-27 | vs CLE | 159 | W 4-2 | 84-73 | 2 | 21,285 | Cha-Seung Baek | Paul Byrd | Cha-Seung Baek | Paul Byrd | George Sherrill | 779 | 806 | -27 |
| 2007-09-28 | vs TEX | 160 | W 6-4 | 85-73 | 2 | 31,954 | Jeff Weaver | Edinson Volquez | J.J. Putz | Mike Wood | | 785 | 810 | -25 |
| 2007-09-29 | vs TEX | 161 | W 5-1 | 86-73 | 2 | 26,799 | Miguel Batista | Kevin Millwood | Miguel Batista | Kevin Millwood | | 790 | 811 | -21 |
| 2007-09-30 | vs TEX | 162 | W 4-2 | 87-73 | 2 | 30,442 | Felix Hernandez | A.J. Murray | Felix Hernandez | A.J. Murray | J.J. Putz | 794 | 813 | -19 |