| 2007-04-03 | @ SFN | 1 | W 7-0 | 1-0 | 1 | 42,773 | Jake Peavy | Barry Zito | Jake Peavy | Barry Zito | | 7 | 0 | 7 |
| 2007-04-04 | @ SFN | 2 | W 5-3 | 2-0 | 1 | 39,938 | Chris Young | Matt Cain | Cla Meredith | Brad Hennessey | Trevor Hoffman | 12 | 3 | 9 |
| 2007-04-05 | @ SFN | 3 | L 3-5 | 2-1 | 2 | 37,914 | Clay Hensley | Matt Morris | Matt Morris | Clay Hensley | Armando Benitez | 15 | 8 | 7 |
| 2007-04-06 | vs COL | 4 | L 3-4 | 2-2 | 4 | 44,267 | Greg Maddux | Jason Hirsh | Jason Hirsh | Greg Maddux | Brian Fuentes | 18 | 12 | 6 |
| 2007-04-07 | vs COL | 5 | W 3-2 | 3-2 | 4 | 40,504 | David Wells | Josh Fogg | Trevor Hoffman | Manuel Corpas | | 21 | 14 | 7 |
| 2007-04-08 | vs COL | 6 | W 2-1 | 4-2 | 3 | 27,086 | Jake Peavy | Aaron Cook | Scott Linebrink | LaTroy Hawkins | | 23 | 15 | 8 |
| 2007-04-09 | vs SFN | 7 | W 1-0 | 5-2 | 2 | 31,388 | Chris Young | Matt Cain | Chris Young | Matt Cain | Trevor Hoffman | 24 | 15 | 9 |
| 2007-04-10 | vs SFN | 8 | L 5-6 | 5-3 | 3 | 28,878 | Clay Hensley | Matt Morris | Matt Morris | Clay Hensley | Armando Benitez | 29 | 21 | 8 |
| 2007-04-11 | vs SFN | 9 | W 4-0 | 6-3 | 3 | 31,568 | Greg Maddux | Noah Lowry | Greg Maddux | Noah Lowry | | 33 | 21 | 12 |
| 2007-04-13 | @ LAN | 10 | L 1-9 | 6-4 | 3 | 49,090 | David Wells | Derek Lowe | Derek Lowe | David Wells | | 34 | 30 | 4 |
| 2007-04-14 | @ LAN | 11 | W 7-2 | 7-4 | 3 | 55,942 | Jake Peavy | Jason Schmidt | Jake Peavy | Jason Schmidt | | 41 | 32 | 9 |
| 2007-04-15 | @ LAN | 12 | L 3-9 | 7-5 | 3 | 55,298 | Chris Young | Randy Wolf | Randy Wolf | Chris Young | | 44 | 41 | 3 |
| 2007-04-16 | @ CHN | 13 | L 4-12 | 7-6 | 3 | 32,126 | Clay Hensley | Jason Marquis | Jason Marquis | Clay Hensley | | 48 | 53 | -5 |
| 2007-04-17 | @ CHN | 14 | W 4-3 | 8-6 | 3 | 36,021 | Greg Maddux | Wade Miller | Doug Brocail | Will Ohman | Trevor Hoffman | 52 | 56 | -4 |
| 2007-04-18 | vs ARI | 15 | L 2-5 | 8-7 | 3 | 26,872 | David Wells | Brandon Webb | Tony Pena | Mike Thompson | Jose Valverde | 54 | 61 | -7 |
| 2007-04-19 | vs ARI | 16 | W 11-6 | 9-7 | 3 | 32,224 | Jake Peavy | Livan Hernandez | Jake Peavy | Livan Hernandez | | 65 | 67 | -2 |
| 2007-04-20 | @ COL | 17 | W 11-1 | 10-7 | 2 | 22,338 | Chris Young | Josh Fogg | Chris Young | Josh Fogg | | 76 | 68 | 8 |
| 2007-04-21 | @ COL | 18 | W 7-3 | 11-7 | 2 | 22,795 | Clay Hensley | Jeff Francis | Clay Hensley | Jeff Francis | | 83 | 71 | 12 |
| 2007-04-22 | @ COL | 19 | L 2-4 | 11-8 | 2 | 25,746 | Greg Maddux | Jason Hirsh | Jason Hirsh | Greg Maddux | Brian Fuentes | 85 | 75 | 10 |
| 2007-04-24 | @ ARI | 20 | W 10-5 | 12-8 | 2 | 19,508 | David Wells | Randy Johnson | David Wells | Randy Johnson | Trevor Hoffman | 95 | 80 | 15 |
| 2007-04-25 | @ ARI | 21 | L 2-3 | 12-9 | 3 | 18,307 | Jake Peavy | Brandon Webb | Tony Pena | Trevor Hoffman | | 97 | 83 | 14 |
| 2007-04-26 | @ ARI | 22 | L 4-7 | 12-10 | 3 | 16,792 | Chris Young | Livan Hernandez | Livan Hernandez | Chris Young | Jose Valverde | 101 | 90 | 11 |
| 2007-04-27 | vs LAN | 23 | L 5-6 | 12-11 | 4 | 44,035 | Clay Hensley | Mark Hendrickson | Rudy Seanez | Trevor Hoffman | Takashi Saito | 106 | 96 | 10 |
| 2007-04-28 | vs LAN | 24 | W 3-2 | 13-11 | 4 | 42,385 | Greg Maddux | Brett Tomko | Greg Maddux | Brett Tomko | Trevor Hoffman | 109 | 98 | 11 |
| 2007-04-29 | vs LAN | 25 | L 4-5 | 13-12 | 4 | 44,028 | David Wells | Derek Lowe | Chad Billingsley | Justin Hampson | | 113 | 103 | 10 |
| 2007-04-30 | vs WAS | 26 | L 2-3 | 13-13 | 4 | 19,769 | Jake Peavy | John Patterson | John Patterson | Jake Peavy | Chad Cordero | 115 | 106 | 9 |
| 2007-05-01 | vs WAS | 27 | W 3-0 | 14-13 | 4 | 19,438 | Chris Young | Shawn Hill | Chris Young | Shawn Hill | Trevor Hoffman | 118 | 106 | 12 |
| 2007-05-02 | vs WAS | 28 | W 7-3 | 15-13 | 4 | 22,153 | Clay Hensley | Matt Chico | Doug Brocail | Matt Chico | | 125 | 109 | 16 |
| 2007-05-04 | @ FLO | 29 | L 4-5 | 15-14 | 3 | 24,691 | Greg Maddux | Dontrelle Willis | Taylor Tankersley | Scott Linebrink | Henry Owens | 129 | 114 | 15 |
| 2007-05-05 | @ FLO | 30 | W 7-6 | 16-14 | 3 | 21,381 | David Wells | Sergio Mitre | Justin Hampson | Lee Gardner | Trevor Hoffman | 136 | 120 | 16 |
| 2007-05-06 | @ FLO | 31 | W 3-1 | 17-14 | 2 | 15,310 | Jake Peavy | Scott Olsen | Jake Peavy | Scott Olsen | Trevor Hoffman | 139 | 121 | 18 |
| 2007-05-07 | @ ATL | 32 | W 4-2 | 18-14 | 2 | 19,189 | Chris Young | Chuck James | Chris Young | Chuck James | Trevor Hoffman | 143 | 123 | 20 |
| 2007-05-08 | @ ATL | 33 | L 2-3 | 18-15 | 2 | 21,748 | Justin Germano | Anthony Lerew | Mike Gonzalez | Heath Bell | Rafael Soriano | 145 | 126 | 19 |
| 2007-05-09 | @ ATL | 34 | L 2-3 | 18-16 | 2 | 36,523 | Greg Maddux | John Smoltz | John Smoltz | Cla Meredith | Rafael Soriano | 147 | 129 | 18 |
| 2007-05-10 | @ ATL | 35 | L 3-5 | 18-17 | 3 | 28,799 | David Wells | Tim Hudson | Tim Hudson | David Wells | Rafael Soriano | 150 | 134 | 16 |
| 2007-05-11 | vs SLN | 36 | W 7-0 | 19-17 | 3 | 38,901 | Jake Peavy | Kip Wells | Jake Peavy | Kip Wells | | 157 | 134 | 23 |
| 2007-05-12 | vs SLN | 37 | L 0-5 | 19-18 | 3 | 44,082 | Chris Young | Braden Looper | Braden Looper | Chris Young | | 157 | 139 | 18 |
| 2007-05-13 | vs SLN | 38 | W 3-0 | 20-18 | 2 | 36,616 | Justin Germano | Anthony Reyes | Justin Germano | Anthony Reyes | Trevor Hoffman | 160 | 139 | 21 |
| 2007-05-14 | vs CIN | 39 | W 7-1 | 21-18 | 2 | 20,262 | Greg Maddux | Matt Belisle | Greg Maddux | Matt Belisle | | 167 | 140 | 27 |
| 2007-05-15 | vs CIN | 40 | L 1-2 | 21-19 | 3 | 26,694 | David Wells | Aaron Harang | David Weathers | Heath Bell | | 168 | 142 | 26 |
| 2007-05-16 | vs CIN | 41 | W 3-2 | 22-19 | 2 | 23,856 | Jake Peavy | Bronson Arroyo | Trevor Hoffman | Bronson Arroyo | | 171 | 144 | 27 |
| 2007-05-18 | @ SEA | 42 | W 8-1 | 23-19 | 2 | 39,531 | Chris Young | Miguel Batista | Chris Young | Miguel Batista | | 179 | 145 | 34 |
| 2007-05-19 | @ SEA | 43 | L 4-7 | 23-20 | 2 | 34,287 | Greg Maddux | Horacio Ramirez | Horacio Ramirez | Greg Maddux | J.J. Putz | 183 | 152 | 31 |
| 2007-05-20 | @ SEA | 44 | W 2-1 | 24-20 | 2 | 38,844 | Justin Germano | Felix Hernandez | Justin Germano | Felix Hernandez | Trevor Hoffman | 185 | 153 | 32 |
| 2007-05-22 | vs CHN | 45 | W 5-1 | 25-20 | 2 | 26,192 | Jake Peavy | Rich Hill | Jake Peavy | Rich Hill | Trevor Hoffman | 190 | 154 | 36 |
| 2007-05-23 | vs CHN | 46 | W 2-1 | 26-20 | 2 | 27,535 | David Wells | Sean Marshall | David Wells | Sean Marshall | Trevor Hoffman | 192 | 155 | 37 |
| 2007-05-24 | vs CHN | 47 | L 1-3 | 26-21 | 2 | 32,258 | Chris Young | Jason Marquis | Bob Howry | Cla Meredith | Ryan Dempster | 193 | 158 | 35 |
| 2007-05-25 | vs MIL | 48 | W 8-6 | 27-21 | 2 | 32,130 | Greg Maddux | David Bush | Greg Maddux | David Bush | Scott Linebrink | 201 | 164 | 37 |
| 2007-05-26 | vs MIL | 49 | W 6-3 | 28-21 | 2 | 35,975 | Justin Germano | Claudio Vargas | Justin Germano | Claudio Vargas | Trevor Hoffman | 207 | 167 | 40 |
| 2007-05-27 | vs MIL | 50 | W 3-0 | 29-21 | 2 | 41,246 | Jake Peavy | Jeff Suppan | Jake Peavy | Jeff Suppan | Trevor Hoffman | 210 | 167 | 43 |
| 2007-05-29 | @ PIT | 51 | L 1-4 | 29-22 | 3 | 15,794 | David Wells | Tom Gorzelanny | Tom Gorzelanny | David Wells | Salomon Torres | 211 | 171 | 40 |
| 2007-05-30 | @ PIT | 52 | W 9-0 | 30-22 | 3 | 12,734 | Chris Young | Paul Maholm | Chris Young | Paul Maholm | | 220 | 171 | 49 |
| 2007-05-31 | @ PIT | 53 | W 4-2 | 31-22 | 2 | 14,966 | Greg Maddux | Shawn Chacon | Cla Meredith | Josh Sharpless | Trevor Hoffman | 224 | 173 | 51 |
| 2007-06-01 | @ WAS | 54 | L 3-4 | 31-23 | 3 | 22,354 | Jake Peavy | Matt Chico | Jon Rauch | Cla Meredith | | 227 | 177 | 50 |
| 2007-06-02 | @ WAS | 55 | W 11-3 | 32-23 | 2 | 21,635 | Justin Germano | Levale Speigner | Justin Germano | Levale Speigner | | 238 | 180 | 58 |
| 2007-06-03 | @ WAS | 56 | W 7-3 | 33-23 | 2 | 26,967 | David Wells | Jason Simontacchi | David Wells | Jason Simontacchi | | 245 | 183 | 62 |
| 2007-06-05 | vs LAN | 57 | W 1-0 | 34-23 | 1 | 31,703 | Chris Young | Jason Schmidt | Scott Linebrink | Rudy Seanez | Trevor Hoffman | 246 | 183 | 63 |
| 2007-06-06 | vs LAN | 58 | W 5-2 | 35-23 | 1 | 31,541 | Greg Maddux | Randy Wolf | Greg Maddux | Randy Wolf | Trevor Hoffman | 251 | 185 | 66 |
| 2007-06-07 | vs LAN | 59 | W 6-5 | 36-23 | 1 | 40,631 | Jake Peavy | Hong-Chih Kuo | Justin Hampson | Jonathan Broxton | | 257 | 190 | 67 |
| 2007-06-08 | vs SEA | 60 | L 5-6 | 36-24 | 1 | 44,325 | Justin Germano | Miguel Batista | Eric O'Flaherty | Cla Meredith | J.J. Putz | 262 | 196 | 66 |
| 2007-06-09 | vs SEA | 61 | L 5-6 | 36-25 | 1 | 37,178 | David Wells | Jeff Weaver | Sean Green | Doug Brocail | J.J. Putz | 267 | 202 | 65 |
| 2007-06-10 | vs SEA | 62 | L 3-4 | 36-26 | 1 | 35,950 | Chris Young | Felix Hernandez | Miguel Batista | Trevor Hoffman | J.J. Putz | 270 | 206 | 64 |
| 2007-06-12 | @ TBA | 63 | L 4-11 | 36-27 | 1 | 12,870 | Greg Maddux | Scott Kazmir | Casey Fossum | Cla Meredith | | 274 | 217 | 57 |
| 2007-06-13 | @ TBA | 64 | W 9-0 | 37-27 | 1 | 12,020 | Jake Peavy | Edwin Jackson | Jake Peavy | Edwin Jackson | | 283 | 217 | 66 |
| 2007-06-14 | @ TBA | 65 | W 7-1 | 38-27 | 1 | 19,270 | Justin Germano | J.P. Howell | Justin Germano | J.P. Howell | | 290 | 218 | 72 |
| 2007-06-15 | @ CHN | 66 | L 1-4 | 38-28 | 2 | 40,479 | David Wells | Ted Lilly | Ted Lilly | David Wells | Ryan Dempster | 291 | 222 | 69 |
| 2007-06-16 | @ CHN | 67 | W 1-0 | 39-28 | 1 | 41,632 | Chris Young | Carlos Zambrano | Heath Bell | Carlos Zambrano | Trevor Hoffman | 292 | 222 | 70 |
| 2007-06-17 | @ CHN | 68 | W 11-3 | 40-28 | 1 | 40,964 | Greg Maddux | Rich Hill | Greg Maddux | Rich Hill | | 303 | 225 | 78 |
| 2007-06-19 | vs BAL | 69 | W 12-6 | 41-28 | 1 | 38,181 | Jake Peavy | Steve Trachsel | Jake Peavy | Steve Trachsel | | 315 | 231 | 84 |
| 2007-06-20 | vs BAL | 70 | L 1-7 | 41-29 | 1 | 26,931 | Justin Germano | Jeremy Guthrie | Jeremy Guthrie | Justin Germano | | 316 | 238 | 78 |
| 2007-06-21 | vs BAL | 71 | L 3-6 | 41-30 | 1 | 40,680 | David Wells | Erik Bedard | Erik Bedard | David Wells | | 319 | 244 | 75 |
| 2007-06-22 | vs BOS | 72 | L 1-2 | 41-31 | 2 | 44,405 | Greg Maddux | Daisuke Matsuzaka | Daisuke Matsuzaka | Greg Maddux | Jonathan Papelbon | 320 | 246 | 74 |
| 2007-06-23 | vs BOS | 73 | W 6-1 | 42-31 | 1 | 44,457 | Chris Young | Tim Wakefield | Chris Young | Tim Wakefield | | 326 | 247 | 79 |
| 2007-06-24 | vs BOS | 74 | L 2-4 | 42-32 | 2 | 44,449 | Jake Peavy | Josh Beckett | Josh Beckett | Jake Peavy | Jonathan Papelbon | 328 | 251 | 77 |
| 2007-06-25 | @ SFN | 75 | L 3-4 | 42-33 | 3 | 41,140 | Justin Germano | Tim Lincecum | Vinnie Chulk | Justin Hampson | | 331 | 255 | 76 |
| 2007-06-26 | @ SFN | 76 | W 3-2 | 43-33 | 2 | 41,329 | David Wells | Barry Zito | Cla Meredith | Randy Messenger | Trevor Hoffman | 334 | 257 | 77 |
| 2007-06-27 | @ SFN | 77 | W 4-2 | 44-33 | 1 | 42,527 | Greg Maddux | Matt Cain | Greg Maddux | Matt Cain | Trevor Hoffman | 338 | 259 | 79 |
| 2007-06-29 | @ LAN | 78 | W 7-6 | 45-33 | 1 | 52,050 | Chris Young | Hong-Chih Kuo | Chris Young | Hong-Chih Kuo | Trevor Hoffman | 345 | 265 | 80 |
| 2007-06-30 | @ LAN | 79 | W 3-1 | 46-33 | 1 | 53,769 | Jake Peavy | Brad Penny | Royce Ring | Brett Tomko | Trevor Hoffman | 348 | 266 | 82 |
| 2007-07-01 | @ LAN | 80 | L 0-5 | 46-34 | 1 | 48,632 | Justin Germano | Chad Billingsley | Chad Billingsley | Justin Germano | | 348 | 271 | 77 |
| 2007-07-02 | vs FLO | 81 | W 3-1 | 47-34 | 1 | 25,857 | David Wells | Sergio Mitre | David Wells | Sergio Mitre | Trevor Hoffman | 351 | 272 | 79 |
| 2007-07-03 | vs FLO | 82 | L 4-6 | 47-35 | 1 | 34,488 | Greg Maddux | Scott Olsen | Justin Miller | Greg Maddux | Kevin Gregg | 355 | 278 | 77 |
| 2007-07-04 | vs FLO | 83 | W 1-0 | 48-35 | 1 | 27,941 | Chris Young | Josh Johnson | Heath Bell | Matt Lindstrom | | 356 | 278 | 78 |
| 2007-07-05 | vs FLO | 84 | L 2-3 | 48-36 | 1 | 32,496 | Jake Peavy | Byung-Hyun Kim | Byung-Hyun Kim | Jake Peavy | Kevin Gregg | 358 | 281 | 77 |
| 2007-07-06 | vs ATL | 85 | L 4-7 | 48-37 | 1 | 37,526 | Justin Germano | Buddy Carlyle | Buddy Carlyle | Justin Germano | | 362 | 288 | 74 |
| 2007-07-07 | vs ATL | 86 | W 8-5 | 49-37 | 1 | 41,419 | David Wells | Jo-Jo Reyes | Heath Bell | Tyler Yates | Trevor Hoffman | 370 | 293 | 77 |
| 2007-07-08 | vs ATL | 87 | L 4-5 | 49-38 | 1 | 41,026 | Greg Maddux | Kyle Davies | Kyle Davies | Greg Maddux | | 374 | 298 | 76 |
| 2007-07-13 | @ ARI | 88 | L 3-8 | 49-39 | 1 | 30,981 | Greg Maddux | Doug Davis | Doug Davis | Greg Maddux | | 377 | 306 | 71 |
| 2007-07-14 | @ ARI | 89 | L 4-5 | 49-40 | 2 | 36,833 | Chris Young | Livan Hernandez | Brandon Lyon | Scott Linebrink | Jose Valverde | 381 | 311 | 70 |
| 2007-07-15 | @ ARI | 90 | W 4-0 | 50-40 | 2 | 30,343 | Justin Germano | Brandon Webb | Justin Germano | Brandon Webb | | 385 | 311 | 74 |
| 2007-07-16 | vs NYN | 91 | W 5-1 | 51-40 | 2 | 35,802 | David Wells | Jorge Sosa | David Wells | Jorge Sosa | | 390 | 312 | 78 |
| 2007-07-17 | vs NYN | 92 | L 0-7 | 51-41 | 2 | 31,660 | Jake Peavy | Orlando Hernandez | Orlando Hernandez | Jake Peavy | | 390 | 319 | 71 |
| 2007-07-18 | vs NYN | 93 | W 5-4 | 52-41 | 2 | 32,524 | Greg Maddux | John Maine | Scott Linebrink | Joe Smith | Trevor Hoffman | 395 | 323 | 72 |
| 2007-07-19 | vs PHI | 94 | W 1-0 | 53-41 | 1 | 30,885 | Chris Young | Cole Hamels | Chris Young | Cole Hamels | Trevor Hoffman | 396 | 323 | 73 |
| 2007-07-20 | vs PHI | 95 | L 3-7 | 53-42 | 1 | 36,113 | Justin Germano | Adam Eaton | Adam Eaton | Justin Germano | Antonio Alfonseca | 399 | 330 | 69 |
| 2007-07-21 | vs PHI | 96 | L 4-12 | 53-43 | 2 | 40,917 | David Wells | Jamie Moyer | Jamie Moyer | David Wells | | 403 | 342 | 61 |
| 2007-07-22 | vs PHI | 97 | L 0-9 | 53-44 | 2 | 37,986 | Jake Peavy | J.D. Durbin | J.D. Durbin | Jake Peavy | | 403 | 351 | 52 |
| 2007-07-23 | @ COL | 98 | L 5-7 | 53-45 | 2 | 31,047 | Greg Maddux | Jeff Francis | Taylor Buchholz | Scott Linebrink | Manuel Corpas | 408 | 358 | 50 |
| 2007-07-24 | @ COL | 99 | W 5-3 | 54-45 | 2 | 37,127 | Chris Young | Ubaldo Jimenez | Heath Bell | Ramon Ramirez | Trevor Hoffman | 413 | 361 | 52 |
| 2007-07-25 | @ COL | 100 | L 2-10 | 54-46 | 2 | 28,162 | Justin Germano | Aaron Cook | Aaron Cook | Justin Germano | | 415 | 371 | 44 |
| 2007-07-26 | @ HOU | 101 | L 1-7 | 54-47 | 3 | 33,718 | David Wells | Wandy Rodriguez | Wandy Rodriguez | David Wells | | 416 | 378 | 38 |
| 2007-07-27 | @ HOU | 102 | W 9-4 | 55-47 | 3 | 39,996 | Jake Peavy | Woody Williams | Jake Peavy | Woody Williams | | 425 | 382 | 43 |
| 2007-07-28 | @ HOU | 103 | L 1-3 | 55-48 | 3 | 42,651 | Greg Maddux | Roy Oswalt | Roy Oswalt | Greg Maddux | Brad Lidge | 426 | 385 | 41 |
| 2007-07-29 | @ HOU | 104 | W 18-11 | 56-48 | 3 | 39,350 | Tim Stauffer | Jason Jennings | Doug Brocail | Jason Jennings | | 444 | 396 | 48 |
| 2007-07-31 | vs ARI | 105 | L 0-4 | 56-49 | 3 | 32,086 | Justin Germano | Brandon Webb | Brandon Webb | Justin Germano | | 444 | 400 | 44 |
| 2007-08-01 | vs ARI | 106 | L 5-9 | 56-50 | 3 | 30,416 | David Wells | Micah Owings | Jose Valverde | Heath Bell | | 449 | 409 | 40 |
| 2007-08-02 | vs ARI | 107 | W 11-0 | 57-50 | 3 | 37,119 | Jake Peavy | Yusmeiro Petit | Jake Peavy | Yusmeiro Petit | | 460 | 409 | 51 |
| 2007-08-03 | vs SFN | 108 | W 4-3 | 58-50 | 2 | 43,523 | Greg Maddux | Matt Cain | Heath Bell | Jack Taschner | | 464 | 412 | 52 |
| 2007-08-04 | vs SFN | 109 | W 3-2 | 59-50 | 2 | 42,497 | Clay Hensley | Pat Misch | Cla Meredith | Randy Messenger | | 467 | 414 | 53 |
| 2007-08-05 | vs SFN | 110 | W 5-4 | 60-50 | 2 | 42,438 | Justin Germano | Noah Lowry | Doug Brocail | Vinnie Chulk | Trevor Hoffman | 472 | 418 | 54 |
| 2007-08-06 | @ SLN | 111 | L 5-10 | 60-51 | 2 | 42,743 | David Wells | Braden Looper | Braden Looper | David Wells | | 477 | 428 | 49 |
| 2007-08-07 | @ SLN | 112 | W 4-0 | 61-51 | 2 | 42,846 | Jake Peavy | Anthony Reyes | Jake Peavy | Anthony Reyes | | 481 | 428 | 53 |
| 2007-08-08 | @ SLN | 113 | L 1-2 | 61-52 | 2 | 42,138 | Greg Maddux | Kip Wells | Kip Wells | Greg Maddux | Jason Isringhausen | 482 | 430 | 52 |
| 2007-08-09 | @ SLN | 114 | L 0-5 | 61-53 | 2 | 42,848 | Chris Young | Joel Pineiro | Joel Pineiro | Chris Young | | 482 | 435 | 47 |
| 2007-08-10 | @ CIN | 115 | W 12-7 | 62-53 | 2 | 21,594 | Wil Ledezma | Matt Belisle | Kevin Cameron | David Weathers | | 494 | 442 | 52 |
| 2007-08-11 | @ CIN | 116 | L 3-8 | 62-54 | 2 | 27,381 | Justin Germano | Bobby Livingston | Bobby Livingston | Justin Hampson | | 497 | 450 | 47 |
| 2007-08-12 | @ CIN | 117 | W 10-4 | 63-54 | 2 | 31,297 | Jake Peavy | Bronson Arroyo | Jake Peavy | Bronson Arroyo | | 507 | 454 | 53 |
| 2007-08-14 | vs COL | 118 | W 8-0 | 64-54 | 2 | 32,049 | Greg Maddux | Jeff Francis | Greg Maddux | Jeff Francis | | 515 | 454 | 61 |
| 2007-08-15 | vs COL | 119 | L 0-3 | 64-55 | 2 | 36,864 | Chris Young | Ubaldo Jimenez | Ubaldo Jimenez | Cla Meredith | Manuel Corpas | 515 | 457 | 58 |
| 2007-08-16 | vs COL | 120 | W 11-9 | 65-55 | 2 | 28,198 | Clay Hensley | Elmer Dessens | Clay Hensley | Jeremy Affeldt | Trevor Hoffman | 526 | 466 | 60 |
| 2007-08-17 | vs HOU | 121 | L 1-3 | 65-56 | 2 | 32,063 | Jake Peavy | Woody Williams | Woody Williams | Heath Bell | Brad Lidge | 527 | 469 | 58 |
| 2007-08-18 | vs HOU | 122 | L 2-3 | 65-57 | 2 | 44,272 | Justin Germano | Roy Oswalt | Dave Borkowski | Justin Germano | Brad Lidge | 529 | 472 | 57 |
| 2007-08-19 | vs HOU | 123 | W 5-3 | 66-57 | 2 | 37,628 | Greg Maddux | Matt Albers | Greg Maddux | Matt Albers | Trevor Hoffman | 534 | 475 | 59 |
| 2007-08-21 | @ NYN | 124 | L 6-7 | 66-58 | 2 | 48,592 | Chris Young | John Maine | Billy Wagner | Trevor Hoffman | | 540 | 482 | 58 |
| 2007-08-22 | @ NYN | 125 | W 7-5 | 67-58 | 2 | 50,060 | Jake Peavy | Brian Lawrence | Jake Peavy | Brian Lawrence | Trevor Hoffman | 547 | 487 | 60 |
| 2007-08-23 | @ NYN | 126 | W 9-8 | 68-58 | 2 | 50,078 | Justin Germano | Tom Glavine | Trevor Hoffman | Aaron Heilman | Heath Bell | 556 | 495 | 61 |
| 2007-08-24 | @ PHI | 127 | W 14-3 | 69-58 | 2 | 39,023 | Greg Maddux | Jamie Moyer | Greg Maddux | Jamie Moyer | | 570 | 498 | 72 |
| 2007-08-25 | @ PHI | 128 | W 4-3 | 70-58 | 2 | 37,957 | Clay Hensley | Kyle Lohse | Heath Bell | Brett Myers | Trevor Hoffman | 574 | 501 | 73 |
| 2007-08-26 | @ PHI | 129 | L 2-14 | 70-59 | 2 | 39,361 | Tim Stauffer | Kyle Kendrick | Kyle Kendrick | Tim Stauffer | John Ennis | 576 | 515 | 61 |
| 2007-08-27 | vs ARI | 130 | W 3-1 | 71-59 | 2 | 25,763 | Jake Peavy | Livan Hernandez | Jake Peavy | Livan Hernandez | Trevor Hoffman | 579 | 516 | 63 |
| 2007-08-28 | vs ARI | 131 | W 6-4 | 72-59 | 2 | 23,006 | Justin Germano | Brandon Webb | Justin Germano | Brandon Webb | Trevor Hoffman | 585 | 520 | 65 |
| 2007-08-29 | vs ARI | 132 | W 3-1 | 73-59 | 1 | 29,021 | Greg Maddux | Micah Owings | Kevin Cameron | Doug Slaten | Heath Bell | 588 | 521 | 67 |
| 2007-08-30 | vs ARI | 133 | L 7-8 | 73-60 | 2 | 28,554 | Chris Young | Doug Davis | Doug Davis | Chris Young | Jose Valverde | 595 | 529 | 66 |
| 2007-08-31 | vs LAN | 134 | W 6-4 | 74-60 | 1 | 44,324 | Jack Cassel | David Wells | Doug Brocail | Rudy Seanez | Trevor Hoffman | 601 | 533 | 68 |
| 2007-09-01 | vs LAN | 135 | W 7-0 | 75-60 | 1 | 42,605 | Jake Peavy | Derek Lowe | Jake Peavy | Derek Lowe | | 608 | 533 | 75 |
| 2007-09-02 | vs LAN | 136 | L 0-5 | 75-61 | 1 | 40,776 | Justin Germano | Chad Billingsley | Chad Billingsley | Justin Germano | | 608 | 538 | 70 |
| 2007-09-03 | @ ARI | 137 | W 10-2 | 76-61 | 1 | 30,531 | Greg Maddux | Micah Owings | Greg Maddux | Micah Owings | | 618 | 540 | 78 |
| 2007-09-04 | @ ARI | 138 | L 1-9 | 76-62 | 1 | 26,063 | Chris Young | Doug Davis | Doug Davis | Chris Young | | 619 | 549 | 70 |
| 2007-09-05 | @ ARI | 139 | L 6-9 | 76-63 | 2 | 28,065 | Jake Peavy | Livan Hernandez | Livan Hernandez | Jake Peavy | Jose Valverde | 625 | 558 | 67 |
| 2007-09-07 | @ COL | 140 | L 4-10 | 76-64 | 2 | 27,247 | Justin Germano | Elmer Dessens | Matt Herges | Justin Germano | | 629 | 568 | 61 |
| 2007-09-08 | @ COL | 141 | W 3-1 | 77-64 | 2 | 30,429 | Greg Maddux | Jeff Francis | Greg Maddux | Jeff Francis | Trevor Hoffman | 632 | 569 | 63 |
| 2007-09-09 | @ COL | 142 | L 2-4 | 77-65 | 2 | 20,260 | Chris Young | Josh Fogg | Josh Fogg | Chris Young | Manuel Corpas | 634 | 573 | 61 |
| 2007-09-11 | @ LAN | 143 | W 9-4 | 78-65 | 2 | 51,620 | Jake Peavy | Esteban Loaiza | Jake Peavy | Esteban Loaiza | | 643 | 577 | 66 |
| 2007-09-12 | @ LAN | 144 | L 1-6 | 78-66 | 2 | 43,699 | Justin Germano | Chad Billingsley | Chad Billingsley | Justin Germano | | 644 | 583 | 61 |
| 2007-09-13 | @ LAN | 145 | L 3-6 | 78-67 | 2 | 44,496 | Greg Maddux | David Wells | David Wells | Greg Maddux | Takashi Saito | 647 | 589 | 58 |
| 2007-09-14 | vs SFN | 146 | W 5-4 | 79-67 | 2 | 32,053 | Chris Young | Barry Zito | Trevor Hoffman | Dan Giese | | 652 | 593 | 59 |
| 2007-09-15 | vs SFN | 147 | W 6-0 | 80-67 | 2 | 41,554 | Brett Tomko | Matt Cain | Brett Tomko | Matt Cain | | 658 | 593 | 65 |
| 2007-09-16 | vs SFN | 148 | W 5-1 | 81-67 | 2 | 34,000 | Jake Peavy | Tim Lincecum | Jake Peavy | Tim Lincecum | | 663 | 594 | 69 |
| 2007-09-17 | vs PIT | 149 | W 3-0 | 82-67 | 2 | 33,557 | Jack Cassel | John Van Benschoten | Jack Cassel | John Van Benschoten | Trevor Hoffman | 666 | 594 | 72 |
| 2007-09-18 | vs PIT | 150 | W 5-3 | 83-67 | 2 | 30,629 | Greg Maddux | Tom Gorzelanny | Greg Maddux | Tom Gorzelanny | Trevor Hoffman | 671 | 597 | 74 |
| 2007-09-19 | vs PIT | 151 | W 5-3 | 84-67 | 2 | 26,354 | Chris Young | Ian Snell | Cla Meredith | Matt Capps | | 676 | 600 | 76 |
| 2007-09-20 | vs PIT | 152 | W 6-3 | 85-67 | 2 | 27,020 | Brett Tomko | Matt Morris | Brett Tomko | Matt Morris | Trevor Hoffman | 682 | 603 | 79 |
| 2007-09-21 | vs COL | 153 | L 1-2 | 85-68 | 2 | 31,288 | Jake Peavy | Franklin Morales | Matt Herges | Joe Thatcher | | 683 | 605 | 78 |
| 2007-09-22 | vs COL | 154 | L 2-6 | 85-69 | 2 | 35,020 | Jack Cassel | Mark Redman | Ryan Speier | Jack Cassel | | 685 | 611 | 74 |
| 2007-09-23 | vs COL | 155 | L 3-7 | 85-70 | 2 | 37,984 | Greg Maddux | Jeff Francis | Jeff Francis | Greg Maddux | | 688 | 618 | 70 |
| 2007-09-24 | @ SFN | 156 | L 4-9 | 85-71 | 2 | 35,650 | Chris Young | Barry Zito | Barry Zito | Chris Young | | 692 | 627 | 65 |
| 2007-09-25 | @ SFN | 157 | W 6-4 | 86-71 | 2 | 35,524 | Brett Tomko | Matt Cain | Joe Thatcher | Brian Wilson | Trevor Hoffman | 698 | 631 | 67 |
| 2007-09-26 | @ SFN | 158 | W 11-3 | 87-71 | 2 | 42,926 | Jake Peavy | Pat Misch | Jake Peavy | Pat Misch | | 709 | 634 | 75 |
| 2007-09-27 | @ MIL | 159 | W 9-5 | 88-71 | 2 | 34,918 | Jack Cassel | Yovani Gallardo | Joe Thatcher | Yovani Gallardo | | 718 | 639 | 79 |
| 2007-09-28 | @ MIL | 160 | W 6-3 | 89-71 | 2 | 38,135 | Greg Maddux | Chris Capuano | Greg Maddux | Claudio Vargas | Trevor Hoffman | 724 | 642 | 82 |
| 2007-09-29 | @ MIL | 161 | L 3-4 | 89-72 | 2 | 40,946 | Chris Young | David Bush | Mitch Stetter | Joe Thatcher | | 727 | 646 | 81 |
| 2007-09-30 | @ MIL | 162 | L 6-11 | 89-73 | 2 | 42,415 | Brett Tomko | Jeff Suppan | Jeff Suppan | Brett Tomko | | 733 | 657 | 76 |
| 2007-10-01 | @ COL | 163 | L 8-9 | 89-74 | 3 | 48,404 | Jake Peavy | Josh Fogg | Ramon Ortiz | Trevor Hoffman | | 741 | 666 | 75 |