| 2007-04-02 | @ HOU | 1 | W 4-2 | 1-0 | 3 | 43,803 | Zach Duke | Roy Oswalt | Matt Capps | Chad Qualls | Salomon Torres | 4 | 2 | 2 |
| 2007-04-03 | @ HOU | 2 | W 3-2 | 2-0 | 3 | 31,238 | Ian Snell | Jason Jennings | Jonah Bayliss | Dan Wheeler | Salomon Torres | 7 | 4 | 3 |
| 2007-04-04 | @ HOU | 3 | W 5-4 | 3-0 | 1 | 25,961 | Tom Gorzelanny | Woody Williams | Tom Gorzelanny | Woody Williams | Salomon Torres | 12 | 8 | 4 |
| 2007-04-06 | @ CIN | 4 | L 1-6 | 3-1 | 2 | 17,837 | Paul Maholm | Matt Belisle | Matt Belisle | Paul Maholm | | 13 | 14 | -1 |
| 2007-04-07 | @ CIN | 5 | L 5-7 | 3-2 | 3 | 15,825 | Tony Armas | Aaron Harang | Aaron Harang | Tony Armas | David Weathers | 18 | 21 | -3 |
| 2007-04-08 | @ CIN | 6 | W 6-3 | 4-2 | 2 | 14,001 | Zach Duke | Eric Milton | Zach Duke | Eric Milton | Salomon Torres | 24 | 24 | 0 |
| 2007-04-09 | vs SLN | 7 | L 0-3 | 4-3 | 2 | 38,429 | Ian Snell | Braden Looper | Braden Looper | Ian Snell | Jason Isringhausen | 24 | 27 | -3 |
| 2007-04-10 | vs SLN | 8 | L 2-3 | 4-4 | 3 | 12,468 | Tom Gorzelanny | Randy Keisler | Brad Thompson | John Wasdin | Jason Isringhausen | 26 | 30 | -4 |
| 2007-04-11 | vs SLN | 9 | L 2-3 | 4-5 | 4 | 9,959 | Paul Maholm | Adam Wainwright | Ryan Franklin | Salomon Torres | | 28 | 33 | -5 |
| 2007-04-13 | vs SFN | 10 | L 5-8 | 4-6 | 5 | 22,117 | Zach Duke | Russ Ortiz | Russ Ortiz | Zach Duke | | 33 | 41 | -8 |
| 2007-04-16 | @ SLN | 11 | W 3-2 | 5-6 | 5 | 43,026 | Ian Snell | Anthony Reyes | Ian Snell | Anthony Reyes | Salomon Torres | 36 | 43 | -7 |
| 2007-04-17 | @ SLN | 12 | W 6-1 | 6-6 | 4 | 42,446 | Tom Gorzelanny | Adam Wainwright | Tom Gorzelanny | Adam Wainwright | | 42 | 44 | -2 |
| 2007-04-18 | @ MIL | 13 | L 3-7 | 6-7 | 4 | 22,331 | Paul Maholm | Claudio Vargas | Claudio Vargas | Paul Maholm | | 45 | 51 | -6 |
| 2007-04-19 | @ MIL | 14 | L 5-7 | 6-8 | 4 | 17,386 | Zach Duke | Jeff Suppan | Jeff Suppan | Zach Duke | Francisco Cordero | 50 | 58 | -8 |
| 2007-04-20 | @ LAN | 15 | L 2-10 | 6-9 | 5 | 43,845 | Tony Armas | Randy Wolf | Randy Wolf | Tony Armas | | 52 | 68 | -16 |
| 2007-04-21 | @ LAN | 16 | L 3-7 | 6-10 | 6 | 48,995 | Ian Snell | Brad Penny | Jonathan Broxton | Jonah Bayliss | | 55 | 75 | -20 |
| 2007-04-22 | @ LAN | 17 | W 7-5 | 7-10 | 5 | 46,741 | Tom Gorzelanny | Brett Tomko | Tom Gorzelanny | Brett Tomko | Salomon Torres | 62 | 80 | -18 |
| 2007-04-24 | vs HOU | 18 | W 3-0 | 8-10 | 4 | 13,062 | Paul Maholm | Woody Williams | Paul Maholm | Woody Williams | | 65 | 80 | -15 |
| 2007-04-25 | vs HOU | 19 | W 4-3 | 9-10 | 3 | 8,201 | Zach Duke | Matt Albers | John Wasdin | Brian Moehler | | 69 | 83 | -14 |
| 2007-04-26 | vs HOU | 20 | W 5-3 | 10-10 | 2 | 12,056 | Tony Armas | Wandy Rodriguez | Jonah Bayliss | Wandy Rodriguez | John Grabow | 74 | 86 | -12 |
| 2007-04-27 | vs CIN | 21 | W 3-1 | 11-10 | 2 | 22,638 | Ian Snell | Eric Milton | Ian Snell | Eric Milton | Salomon Torres | 77 | 87 | -10 |
| 2007-04-28 | vs CIN | 22 | L 1-8 | 11-11 | 2 | 29,514 | Tom Gorzelanny | Matt Belisle | Matt Belisle | Tom Gorzelanny | | 78 | 95 | -17 |
| 2007-04-29 | vs CIN | 23 | L 5-9 | 11-12 | 3 | 18,409 | Paul Maholm | Aaron Harang | Aaron Harang | Paul Maholm | | 83 | 104 | -21 |
| 2007-04-30 | vs CHN | 24 | W 3-2 | 12-12 | 2 | 11,437 | Zach Duke | Rich Hill | Matt Capps | Michael Wuertz | Salomon Torres | 86 | 106 | -20 |
| 2007-05-01 | vs CHN | 25 | L 6-8 | 12-13 | 3 | 13,082 | Tony Armas | Ted Lilly | Rocky Cherry | Jonah Bayliss | Ryan Dempster | 92 | 114 | -22 |
| 2007-05-02 | vs CHN | 26 | L 1-7 | 12-14 | 4 | 21,765 | Ian Snell | Jason Marquis | Jason Marquis | Ian Snell | | 93 | 121 | -28 |
| 2007-05-03 | @ MIL | 27 | W 4-2 | 13-14 | 2 | 15,602 | Tom Gorzelanny | David Bush | Tom Gorzelanny | David Bush | Salomon Torres | 97 | 123 | -26 |
| 2007-05-04 | @ MIL | 28 | L 0-10 | 13-15 | 3 | 40,190 | Paul Maholm | Claudio Vargas | Claudio Vargas | Paul Maholm | | 97 | 133 | -36 |
| 2007-05-05 | @ MIL | 29 | L 3-6 | 13-16 | 4 | 40,361 | Zach Duke | Jeff Suppan | Jeff Suppan | Zach Duke | Francisco Cordero | 100 | 139 | -39 |
| 2007-05-06 | @ MIL | 30 | L 4-6 | 13-17 | 5 | 37,761 | Tony Armas | Ben Sheets | Carlos Villanueva | John Grabow | Francisco Cordero | 104 | 145 | -41 |
| 2007-05-08 | @ CHN | 31 | W 4-3 | 14-17 | 4 | 39,708 | Ian Snell | Ted Lilly | Jonah Bayliss | Neal Cotts | Salomon Torres | 108 | 148 | -40 |
| 2007-05-09 | @ CHN | 32 | L 0-1 | 14-18 | 4 | 40,264 | Tom Gorzelanny | Jason Marquis | Jason Marquis | Tom Gorzelanny | | 108 | 149 | -41 |
| 2007-05-10 | @ CHN | 33 | W 6-4 | 15-18 | 4 | 41,101 | Paul Maholm | Carlos Zambrano | Paul Maholm | Carlos Zambrano | Salomon Torres | 114 | 153 | -39 |
| 2007-05-11 | vs ATL | 34 | L 1-4 | 15-19 | 4 | 23,376 | Zach Duke | Kyle Davies | Kyle Davies | Zach Duke | Mike Gonzalez | 115 | 157 | -42 |
| 2007-05-12 | vs ATL | 35 | L 2-9 | 15-20 | 5 | 34,775 | Tony Armas | Chuck James | Chuck James | Tony Armas | | 117 | 166 | -49 |
| 2007-05-13 | vs ATL | 36 | W 13-2 | 16-20 | 4 | 19,484 | Ian Snell | Anthony Lerew | Ian Snell | Anthony Lerew | | 130 | 168 | -38 |
| 2007-05-14 | vs FLO | 37 | W 7-0 | 17-20 | 4 | 12,958 | Tom Gorzelanny | Dontrelle Willis | Tom Gorzelanny | Dontrelle Willis | | 137 | 168 | -31 |
| 2007-05-15 | vs FLO | 38 | L 3-9 | 17-21 | 4 | 12,769 | Paul Maholm | Sergio Mitre | Sergio Mitre | Paul Maholm | | 140 | 177 | -37 |
| 2007-05-16 | vs FLO | 39 | L 3-4 | 17-22 | 4 | 15,086 | Zach Duke | Scott Olsen | Taylor Tankersley | Matt Capps | Kevin Gregg | 143 | 181 | -38 |
| 2007-05-17 | vs FLO | 40 | W 7-2 | 18-22 | 4 | 9,582 | Tony Armas | Ricky Nolasco | Shawn Chacon | Ricky Nolasco | | 150 | 183 | -33 |
| 2007-05-18 | vs ARI | 41 | W 11-5 | 19-22 | 4 | 32,682 | Ian Snell | Doug Davis | Ian Snell | Doug Davis | | 161 | 188 | -27 |
| 2007-05-19 | vs ARI | 42 | L 8-9 | 19-23 | 4 | 30,677 | Tom Gorzelanny | Micah Owings | Doug Slaten | Matt Capps | Jose Valverde | 169 | 197 | -28 |
| 2007-05-20 | vs ARI | 43 | L 2-5 | 19-24 | 4 | 24,282 | Paul Maholm | Randy Johnson | Randy Johnson | Paul Maholm | Jose Valverde | 171 | 202 | -31 |
| 2007-05-22 | @ SLN | 44 | L 4-9 | 19-25 | 4 | 42,679 | Zach Duke | Adam Wainwright | Adam Wainwright | Zach Duke | | 175 | 211 | -36 |
| 2007-05-23 | @ SLN | 45 | L 3-5 | 19-26 | 4 | 42,245 | Ian Snell | Kip Wells | Kip Wells | Ian Snell | Jason Isringhausen | 178 | 216 | -38 |
| 2007-05-24 | @ SLN | 46 | L 1-3 | 19-27 | 5 | 44,296 | Tom Gorzelanny | Braden Looper | Braden Looper | Tom Gorzelanny | Jason Isringhausen | 179 | 219 | -40 |
| 2007-05-25 | @ CIN | 47 | W 10-4 | 20-27 | 4 | 36,455 | Paul Maholm | Aaron Harang | Jonah Bayliss | David Weathers | | 189 | 223 | -34 |
| 2007-05-26 | @ CIN | 48 | W 9-5 | 21-27 | 3 | 32,380 | Shawn Chacon | Bronson Arroyo | John Grabow | Bronson Arroyo | | 198 | 228 | -30 |
| 2007-05-27 | @ CIN | 49 | W 14-10 | 22-27 | 3 | 27,209 | Zach Duke | Kirk Saarloos | Zach Duke | Kirk Saarloos | | 212 | 238 | -26 |
| 2007-05-28 | @ CIN | 50 | L 0-4 | 22-28 | 3 | 17,905 | Ian Snell | Kyle Lohse | Kyle Lohse | Ian Snell | | 212 | 242 | -30 |
| 2007-05-29 | vs SDN | 51 | W 4-1 | 23-28 | 2 | 15,794 | Tom Gorzelanny | David Wells | Tom Gorzelanny | David Wells | Salomon Torres | 216 | 243 | -27 |
| 2007-05-30 | vs SDN | 52 | L 0-9 | 23-29 | 2 | 12,734 | Paul Maholm | Chris Young | Chris Young | Paul Maholm | | 216 | 252 | -36 |
| 2007-05-31 | vs SDN | 53 | L 2-4 | 23-30 | 2 | 14,966 | Shawn Chacon | Greg Maddux | Cla Meredith | Josh Sharpless | Trevor Hoffman | 218 | 256 | -38 |
| 2007-06-01 | vs LAN | 54 | L 4-5 | 23-31 | 3 | 20,164 | Zach Duke | Randy Wolf | Randy Wolf | Zach Duke | Takashi Saito | 222 | 261 | -39 |
| 2007-06-02 | vs LAN | 55 | W 3-1 | 24-31 | 2 | 31,931 | Ian Snell | Hong-Chih Kuo | Ian Snell | Hong-Chih Kuo | Matt Capps | 225 | 262 | -37 |
| 2007-06-03 | vs LAN | 56 | L 4-5 | 24-32 | 3 | 23,458 | Tom Gorzelanny | Brad Penny | Chad Billingsley | Salomon Torres | Joe Beimel | 229 | 267 | -38 |
| 2007-06-04 | vs LAN | 57 | L 5-6 | 24-33 | 4 | 15,846 | Paul Maholm | Derek Lowe | Derek Lowe | Paul Maholm | Jonathan Broxton | 234 | 273 | -39 |
| 2007-06-05 | @ WAS | 58 | W 7-6 | 25-33 | 3 | 19,169 | Shawn Chacon | Michael Bacsik | Shawn Chacon | Michael Bacsik | Matt Capps | 241 | 279 | -38 |
| 2007-06-06 | @ WAS | 59 | L 5-6 | 25-34 | 4 | 24,755 | Zach Duke | Micah Bowie | Chad Cordero | Salomon Torres | | 246 | 285 | -39 |
| 2007-06-07 | @ WAS | 60 | W 3-2 | 26-34 | 4 | 25,622 | Ian Snell | Matt Chico | Matt Capps | Chad Cordero | | 249 | 287 | -38 |
| 2007-06-08 | @ NYA | 61 | L 4-5 | 26-35 | 4 | 54,240 | Tom Gorzelanny | Andy Pettitte | Mariano Rivera | Matt Capps | | 253 | 292 | -39 |
| 2007-06-09 | @ NYA | 62 | L 3-9 | 26-36 | 5 | 54,296 | Paul Maholm | Roger Clemens | Roger Clemens | Paul Maholm | | 256 | 301 | -45 |
| 2007-06-10 | @ NYA | 63 | L 6-13 | 26-37 | 5 | 54,292 | Shawn Chacon | Tyler Clippard | Sean Henn | Shawn Chacon | | 262 | 314 | -52 |
| 2007-06-12 | vs TEX | 64 | W 7-5 | 27-37 | 5 | 21,158 | Zach Duke | Kevin Millwood | Zach Duke | Kevin Millwood | Matt Capps | 269 | 319 | -50 |
| 2007-06-13 | vs TEX | 65 | W 8-1 | 28-37 | 4 | 16,110 | Ian Snell | Rob Tejeda | Ian Snell | Rob Tejeda | | 277 | 320 | -43 |
| 2007-06-14 | vs TEX | 66 | L 0-6 | 28-38 | 4 | 17,214 | Tom Gorzelanny | Kameron Loe | Kameron Loe | Tom Gorzelanny | | 277 | 326 | -49 |
| 2007-06-15 | vs CHA | 67 | W 4-2 | 29-38 | 4 | 26,647 | Paul Maholm | Jon Garland | Paul Maholm | Jon Garland | Matt Capps | 281 | 328 | -47 |
| 2007-06-16 | vs CHA | 68 | L 1-6 | 29-39 | 5 | 36,610 | John Van Benschoten | Mark Buehrle | Mark Buehrle | John Van Benschoten | | 282 | 334 | -52 |
| 2007-06-17 | vs CHA | 69 | W 8-7 | 30-39 | 5 | 26,830 | Zach Duke | Javier Vazquez | Shawn Chacon | Nick Masset | Matt Capps | 290 | 341 | -51 |
| 2007-06-19 | @ SEA | 70 | W 5-3 | 31-39 | 4 | 24,520 | Tom Gorzelanny | Miguel Batista | Tom Gorzelanny | Miguel Batista | Shawn Chacon | 295 | 344 | -49 |
| 2007-06-20 | @ SEA | 71 | L 0-7 | 31-40 | 4 | 23,553 | Paul Maholm | Jeff Weaver | Jeff Weaver | Paul Maholm | | 295 | 351 | -56 |
| 2007-06-21 | @ SEA | 72 | L 0-3 | 31-41 | 5 | 22,950 | John Van Benschoten | Felix Hernandez | Felix Hernandez | John Van Benschoten | J.J. Putz | 295 | 354 | -59 |
| 2007-06-22 | @ ANA | 73 | L 4-5 | 31-42 | 5 | 43,545 | Zach Duke | Joe Saunders | Scot Shields | Jonah Bayliss | | 299 | 359 | -60 |
| 2007-06-23 | @ ANA | 74 | L 1-10 | 31-43 | 5 | 44,010 | Ian Snell | Kelvim Escobar | Kelvim Escobar | Ian Snell | | 300 | 369 | -69 |
| 2007-06-24 | @ ANA | 75 | L 3-4 | 31-44 | 5 | 42,346 | Tom Gorzelanny | Bartolo Colon | Chris Bootcheck | Matt Capps | | 303 | 373 | -70 |
| 2007-06-26 | @ FLO | 76 | W 3-2 | 32-44 | 4 | 11,044 | Paul Maholm | Dontrelle Willis | Paul Maholm | Dontrelle Willis | Matt Capps | 306 | 375 | -69 |
| 2007-06-27 | @ FLO | 77 | W 7-5 | 33-44 | 4 | 11,222 | John Van Benschoten | Sergio Mitre | Shawn Chacon | Kevin Gregg | Matt Capps | 313 | 380 | -67 |
| 2007-06-28 | @ FLO | 78 | L 7-9 | 33-45 | 4 | 31,628 | Zach Duke | Scott Olsen | Scott Olsen | Zach Duke | Kevin Gregg | 320 | 389 | -69 |
| 2007-06-29 | vs WAS | 79 | W 3-2 | 34-45 | 4 | 32,361 | Ian Snell | Matt Chico | Matt Capps | Jon Rauch | | 323 | 391 | -68 |
| 2007-06-30 | vs WAS | 80 | W 7-2 | 35-45 | 4 | 26,959 | Tom Gorzelanny | Jason Bergmann | Tom Gorzelanny | Jason Bergmann | | 330 | 393 | -63 |
| 2007-07-01 | vs WAS | 81 | L 2-3 | 35-46 | 4 | 19,149 | Paul Maholm | Michael Bacsik | Michael Bacsik | Paul Maholm | Chad Cordero | 332 | 396 | -64 |
| 2007-07-02 | vs MIL | 82 | L 3-10 | 35-47 | 5 | 14,455 | John Van Benschoten | Jeff Suppan | Carlos Villanueva | Masumi Kuwata | | 335 | 406 | -71 |
| 2007-07-03 | vs MIL | 83 | W 6-2 | 36-47 | 5 | 25,416 | Shane Youman | Chris Capuano | Shane Youman | Yovani Gallardo | | 341 | 408 | -67 |
| 2007-07-04 | vs MIL | 84 | W 5-3 | 37-47 | 4 | 35,878 | Ian Snell | Claudio Vargas | Ian Snell | Claudio Vargas | Matt Capps | 346 | 411 | -65 |
| 2007-07-05 | vs MIL | 85 | W 6-3 | 38-47 | 4 | 15,134 | Tom Gorzelanny | Ben Sheets | Tom Gorzelanny | Ben Sheets | Matt Capps | 352 | 414 | -62 |
| 2007-07-06 | vs CHN | 86 | W 8-4 | 39-47 | 4 | 27,868 | Paul Maholm | Jason Marquis | Paul Maholm | Jason Marquis | | 360 | 418 | -58 |
| 2007-07-07 | vs CHN | 87 | L 1-7 | 39-48 | 4 | 33,293 | John Van Benschoten | Ted Lilly | Ted Lilly | John Van Benschoten | | 361 | 425 | -64 |
| 2007-07-08 | vs CHN | 88 | W 6-2 | 40-48 | 4 | 22,470 | Shane Youman | Carlos Zambrano | Shane Youman | Carlos Zambrano | | 367 | 427 | -60 |
| 2007-07-13 | @ ATL | 89 | L 1-9 | 40-49 | 4 | 38,922 | Ian Snell | Tim Hudson | Tim Hudson | Ian Snell | | 368 | 436 | -68 |
| 2007-07-14 | @ ATL | 90 | L 4-5 | 40-50 | 4 | 44,041 | Tom Gorzelanny | Chuck James | Bob Wickman | Shawn Chacon | | 372 | 441 | -69 |
| 2007-07-15 | @ ATL | 91 | L 1-5 | 40-51 | 4 | 30,756 | Paul Maholm | Buddy Carlyle | Buddy Carlyle | Paul Maholm | | 373 | 446 | -73 |
| 2007-07-16 | vs COL | 92 | L 8-10 | 40-52 | 4 | 16,423 | John Van Benschoten | Taylor Buchholz | LaTroy Hawkins | John Van Benschoten | Manuel Corpas | 381 | 456 | -75 |
| 2007-07-17 | vs COL | 93 | L 2-6 | 40-53 | 4 | 21,604 | Shane Youman | Josh Fogg | Josh Fogg | Shane Youman | | 383 | 462 | -79 |
| 2007-07-18 | vs COL | 94 | L 3-5 | 40-54 | 4 | 19,285 | Ian Snell | Jeff Francis | Jeff Francis | Ian Snell | Manuel Corpas | 386 | 467 | -81 |
| 2007-07-20 | vs HOU | 95 | L 1-2 | 40-55 | 6 | 33,541 | Tom Gorzelanny | Roy Oswalt | Roy Oswalt | Tom Gorzelanny | Brad Lidge | 387 | 469 | -82 |
| 2007-07-21 | vs HOU | 96 | W 7-3 | 41-55 | 4 | 32,068 | Paul Maholm | Wandy Rodriguez | Paul Maholm | Wandy Rodriguez | | 394 | 472 | -78 |
| 2007-07-22 | vs HOU | 97 | L 0-1 | 41-56 | 5 | 22,404 | Shane Youman | Woody Williams | Woody Williams | Shane Youman | Brad Lidge | 394 | 473 | -79 |
| 2007-07-24 | @ NYN | 98 | L 4-8 | 41-57 | 5 | 49,122 | Ian Snell | John Maine | John Maine | Ian Snell | | 398 | 481 | -83 |
| 2007-07-25 | @ NYN | 99 | L 3-6 | 41-58 | 6 | 49,906 | Tom Gorzelanny | Tom Glavine | Tom Glavine | Tom Gorzelanny | Billy Wagner | 401 | 487 | -86 |
| 2007-07-26 | @ NYN | 100 | W 8-4 | 42-58 | 6 | 52,150 | Paul Maholm | Oliver Perez | Paul Maholm | Oliver Perez | | 409 | 491 | -82 |
| 2007-07-27 | @ PHI | 101 | L 1-8 | 42-59 | 6 | 37,136 | John Van Benschoten | Jamie Moyer | Jamie Moyer | John Van Benschoten | | 410 | 499 | -89 |
| 2007-07-28 | @ PHI | 102 | L 5-10 | 42-60 | 6 | 45,149 | Shane Youman | J.D. Durbin | J.D. Durbin | Shane Youman | | 415 | 509 | -94 |
| 2007-07-29 | @ PHI | 103 | L 1-5 | 42-61 | 6 | 40,030 | Ian Snell | Kyle Kendrick | Kyle Kendrick | Ian Snell | | 416 | 514 | -98 |
| 2007-07-31 | vs SLN | 104 | L 4-6 | 42-62 | 6 | 24,085 | Paul Maholm | Adam Wainwright | Adam Wainwright | Paul Maholm | Jason Isringhausen | 420 | 520 | -100 |
| 2007-08-01 | vs SLN | 105 | W 15-1 | 43-62 | 6 | 17,041 | Tony Armas | Braden Looper | Tony Armas | Braden Looper | | 435 | 521 | -86 |
| 2007-08-02 | vs SLN | 106 | W 5-4 | 44-62 | 5 | 19,132 | Shane Youman | Anthony Reyes | Salomon Torres | Brad Thompson | | 440 | 525 | -85 |
| 2007-08-03 | vs CIN | 107 | L 4-13 | 44-63 | 6 | 22,874 | Ian Snell | Matt Belisle | Matt Belisle | Ian Snell | | 444 | 538 | -94 |
| 2007-08-04 | vs CIN | 108 | L 8-9 | 44-64 | 6 | 33,466 | Matt Morris | Bobby Livingston | Jared Burton | Matt Capps | David Weathers | 452 | 547 | -95 |
| 2007-08-07 | @ ARI | 109 | W 8-3 | 45-64 | 6 | 25,340 | Tom Gorzelanny | Micah Owings | Tom Gorzelanny | Micah Owings | | 460 | 550 | -90 |
| 2007-08-08 | @ ARI | 110 | L 6-10 | 45-65 | 6 | 23,082 | Paul Maholm | Byung-Hyun Kim | Edgar Gonzalez | Paul Maholm | Jose Valverde | 466 | 560 | -94 |
| 2007-08-09 | @ ARI | 111 | L 2-4 | 45-66 | 6 | 22,316 | Ian Snell | Doug Davis | Doug Davis | Shawn Chacon | Jose Valverde | 468 | 564 | -96 |
| 2007-08-10 | @ SFN | 112 | W 8-7 | 46-66 | 6 | 41,923 | Matt Morris | Russ Ortiz | John Grabow | Vinnie Chulk | Matt Capps | 476 | 571 | -95 |
| 2007-08-11 | @ SFN | 113 | W 13-3 | 47-66 | 6 | 43,105 | Tony Armas | Tim Lincecum | Tony Armas | Tim Lincecum | | 489 | 574 | -85 |
| 2007-08-12 | @ SFN | 114 | W 5-0 | 48-66 | 6 | 41,976 | Tom Gorzelanny | Barry Zito | Tom Gorzelanny | Barry Zito | | 494 | 574 | -80 |
| 2007-08-13 | vs SFN | 115 | W 3-1 | 48-67 | 6 | 0 | Paul Maholm | Matt Cain | Paul Maholm | Matt Cain | | 497 | 575 | -78 |
| 2007-08-13 | vs SFN | 116 | L 3-10 | 48-67 | 6 | 25,434 | Shane Youman | Noah Lowry | Noah Lowry | Shane Youman | | 500 | 585 | -85 |
| 2007-08-14 | vs NYN | 117 | L 4-5 | 48-68 | 6 | 25,277 | Ian Snell | Orlando Hernandez | Jorge Sosa | Salomon Torres | Billy Wagner | 504 | 590 | -86 |
| 2007-08-15 | vs NYN | 118 | L 8-10 | 48-69 | 6 | 18,241 | Matt Morris | John Maine | John Maine | Matt Morris | Billy Wagner | 512 | 600 | -88 |
| 2007-08-16 | vs NYN | 119 | W 10-7 | 49-69 | 6 | 36,447 | Tony Armas | Brian Lawrence | Damaso Marte | Aaron Heilman | Matt Capps | 522 | 607 | -85 |
| 2007-08-17 | vs PHI | 120 | L 8-11 | 49-70 | 6 | 37,072 | Tom Gorzelanny | J.D. Durbin | J.D. Durbin | Tom Gorzelanny | | 530 | 618 | -88 |
| 2007-08-18 | vs PHI | 121 | W 11-6 | 50-70 | 6 | 38,152 | Paul Maholm | Jamie Moyer | Paul Maholm | Jamie Moyer | | 541 | 624 | -83 |
| 2007-08-19 | vs PHI | 122 | W 8-4 | 51-70 | 6 | 31,277 | Ian Snell | Kyle Lohse | Ian Snell | J.C. Romero | | 549 | 628 | -79 |
| 2007-08-20 | @ COL | 123 | W 4-2 | 52-70 | 6 | 22,682 | Matt Morris | Ubaldo Jimenez | Damaso Marte | Brian Fuentes | Matt Capps | 553 | 630 | -77 |
| 2007-08-21 | @ COL | 124 | L 2-9 | 52-71 | 6 | 21,136 | Tony Armas | Elmer Dessens | Taylor Buchholz | Tony Armas | | 555 | 639 | -84 |
| 2007-08-22 | @ COL | 125 | W 11-2 | 53-71 | 6 | 20,629 | Tom Gorzelanny | Josh Fogg | Tom Gorzelanny | Josh Fogg | | 566 | 641 | -75 |
| 2007-08-23 | @ COL | 126 | W 5-1 | 54-71 | 6 | 20,380 | Paul Maholm | Franklin Morales | Paul Maholm | Franklin Morales | | 571 | 642 | -71 |
| 2007-08-24 | @ HOU | 127 | W 8-3 | 55-71 | 6 | 41,403 | Ian Snell | Matt Albers | Shane Youman | Travis Driskill | | 579 | 645 | -66 |
| 2007-08-25 | @ HOU | 128 | W 4-1 | 56-71 | 5 | 41,109 | Matt Morris | Troy Patton | Matt Morris | Troy Patton | Matt Capps | 583 | 646 | -63 |
| 2007-08-26 | @ HOU | 129 | L 4-5 | 56-72 | 6 | 42,564 | Tony Armas | Wandy Rodriguez | Mark McLemore | Shawn Chacon | Brad Lidge | 587 | 651 | -64 |
| 2007-08-28 | vs CIN | 130 | W 6-4 | 57-72 | 5 | 0 | Tom Gorzelanny | Elizardo Ramirez | Tom Gorzelanny | Elizardo Ramirez | Matt Capps | 593 | 655 | -62 |
| 2007-08-28 | vs CIN | 131 | W 3-2 | 57-72 | 5 | 17,669 | Paul Maholm | Bronson Arroyo | Shawn Chacon | Bill Bray | Matt Capps | 596 | 657 | -61 |
| 2007-08-29 | vs CIN | 132 | L 0-8 | 57-73 | 6 | 14,191 | Ian Snell | Aaron Harang | Aaron Harang | Ian Snell | | 596 | 665 | -69 |
| 2007-08-30 | vs CIN | 133 | L 4-5 | 57-74 | 6 | 12,643 | Matt Morris | Matt Belisle | Jared Burton | Matt Capps | David Weathers | 600 | 670 | -70 |
| 2007-08-31 | @ MIL | 134 | L 2-3 | 57-75 | 6 | 35,689 | Tony Armas | Yovani Gallardo | Yovani Gallardo | Tony Armas | Francisco Cordero | 602 | 673 | -71 |
| 2007-09-01 | @ MIL | 135 | L 3-12 | 57-76 | 6 | 34,190 | Shane Youman | David Bush | David Bush | Shane Youman | | 605 | 685 | -80 |
| 2007-09-02 | @ MIL | 136 | L 4-7 | 57-77 | 6 | 39,339 | Tom Gorzelanny | Jeff Suppan | Jeff Suppan | Franquelis Osoria | Francisco Cordero | 609 | 692 | -83 |
| 2007-09-03 | @ SLN | 137 | W 11-0 | 58-77 | 6 | 42,238 | Ian Snell | Kip Wells | Ian Snell | Kip Wells | | 620 | 692 | -72 |
| 2007-09-04 | @ SLN | 138 | L 2-6 | 58-78 | 6 | 42,300 | Matt Morris | Joel Pineiro | Joel Pineiro | Matt Morris | Ryan Franklin | 622 | 698 | -76 |
| 2007-09-05 | @ SLN | 139 | W 8-2 | 59-78 | 6 | 42,299 | Tony Armas | Mark Mulder | Tony Armas | Mark Mulder | | 630 | 700 | -70 |
| 2007-09-06 | @ SLN | 140 | L 4-16 | 59-79 | 6 | 42,330 | Bryan Bullington | Mike Maroth | Kelvin Jimenez | Bryan Bullington | | 634 | 716 | -82 |
| 2007-09-07 | vs CHN | 141 | W 6-1 | 60-79 | 6 | 24,489 | Tom Gorzelanny | Rich Hill | Tom Gorzelanny | Rich Hill | | 640 | 717 | -77 |
| 2007-09-08 | vs CHN | 142 | L 1-5 | 60-80 | 6 | 33,373 | Ian Snell | Carlos Zambrano | Carlos Zambrano | Ian Snell | | 641 | 722 | -81 |
| 2007-09-09 | vs CHN | 143 | W 10-5 | 61-80 | 6 | 21,861 | Matt Morris | Steve Trachsel | Matt Morris | Steve Trachsel | | 651 | 727 | -76 |
| 2007-09-10 | vs MIL | 144 | W 9-0 | 62-80 | 5 | 13,683 | Tony Armas | Carlos Villanueva | Tony Armas | Carlos Villanueva | | 660 | 727 | -67 |
| 2007-09-11 | vs MIL | 145 | L 1-6 | 62-81 | 6 | 11,962 | Bryan Bullington | Yovani Gallardo | Yovani Gallardo | Bryan Bullington | | 661 | 733 | -72 |
| 2007-09-12 | vs MIL | 146 | W 7-4 | 63-81 | 5 | 10,566 | Tom Gorzelanny | David Bush | John Grabow | Derrick Turnbow | Matt Capps | 668 | 737 | -69 |
| 2007-09-14 | @ HOU | 147 | W 4-3 | 64-81 | 5 | 35,352 | Ian Snell | Roy Oswalt | Romulo Sanchez | Chad Qualls | Matt Capps | 672 | 740 | -68 |
| 2007-09-15 | @ HOU | 148 | L 7-9 | 64-82 | 5 | 40,425 | Matt Morris | Wandy Rodriguez | Juan Gutierrez | Matt Morris | Brad Lidge | 679 | 749 | -70 |
| 2007-09-16 | @ HOU | 149 | L 3-15 | 64-83 | 6 | 35,715 | Paul Maholm | Brandon Backe | Brandon Backe | Paul Maholm | | 682 | 764 | -82 |
| 2007-09-17 | @ SDN | 150 | L 0-3 | 64-84 | 6 | 33,557 | John Van Benschoten | Jack Cassel | Jack Cassel | John Van Benschoten | Trevor Hoffman | 682 | 767 | -85 |
| 2007-09-18 | @ SDN | 151 | L 3-5 | 64-85 | 6 | 30,629 | Tom Gorzelanny | Greg Maddux | Greg Maddux | Tom Gorzelanny | Trevor Hoffman | 685 | 772 | -87 |
| 2007-09-19 | @ SDN | 152 | L 3-5 | 64-86 | 6 | 26,354 | Ian Snell | Chris Young | Cla Meredith | Matt Capps | | 688 | 777 | -89 |
| 2007-09-20 | @ SDN | 153 | L 3-6 | 64-87 | 6 | 27,020 | Matt Morris | Brett Tomko | Brett Tomko | Matt Morris | Trevor Hoffman | 691 | 783 | -92 |
| 2007-09-21 | @ CHN | 154 | L 8-13 | 64-88 | 6 | 41,591 | Paul Maholm | Jason Marquis | Scott Eyre | Franquelis Osoria | | 699 | 796 | -97 |
| 2007-09-22 | @ CHN | 155 | L 5-9 | 64-89 | 6 | 41,271 | Zach Duke | Rich Hill | Rich Hill | Zach Duke | | 704 | 805 | -101 |
| 2007-09-23 | @ CHN | 156 | L 0-8 | 64-90 | 6 | 41,364 | Tom Gorzelanny | Carlos Zambrano | Carlos Zambrano | Tom Gorzelanny | | 704 | 813 | -109 |
| 2007-09-25 | vs ARI | 157 | W 6-5 | 65-90 | 6 | 14,569 | Ian Snell | Doug Davis | Salomon Torres | Brandon Lyon | Matt Capps | 710 | 818 | -108 |
| 2007-09-26 | vs ARI | 158 | W 5-1 | 66-90 | 6 | 16,289 | Matt Morris | Livan Hernandez | Matt Morris | Livan Hernandez | | 715 | 819 | -104 |
| 2007-09-27 | vs ARI | 159 | L 0-8 | 66-91 | 6 | 11,335 | John Van Benschoten | Micah Owings | Micah Owings | John Van Benschoten | | 715 | 827 | -112 |
| 2007-09-28 | vs SLN | 160 | L 1-6 | 66-92 | 6 | 30,603 | Zach Duke | Todd Wellemeyer | Russ Springer | John Grabow | | 716 | 833 | -117 |
| 2007-09-29 | vs SLN | 161 | L 3-7 | 66-93 | 6 | 35,169 | Tom Gorzelanny | Adam Wainwright | Adam Wainwright | Tom Gorzelanny | | 719 | 840 | -121 |
| 2007-09-30 | vs SLN | 162 | L 5-6 | 66-94 | 6 | 25,664 | Bryan Bullington | Troy Percival | Kip Wells | Bryan Bullington | Jason Isringhausen | 724 | 846 | -122 |