| 2007-04-02 | @ SEA | 1 | L 0-4 | 0-1 | 3 | 46,003 | Dan Haren | Felix Hernandez | Felix Hernandez | Dan Haren | | 0 | 4 | -4 |
| 2007-04-03 | @ SEA | 2 | L 4-8 | 0-2 | 3 | 25,287 | Joe Blanton | Jarrod Washburn | Julio Mateo | Kiko Calero | | 4 | 12 | -8 |
| 2007-04-04 | @ SEA | 3 | W 9-0 | 1-2 | 3 | 22,816 | Rich Harden | Miguel Batista | Rich Harden | Miguel Batista | | 13 | 12 | 1 |
| 2007-04-05 | @ ANA | 4 | W 4-3 | 2-2 | 3 | 39,234 | Chad Gaudin | Joe Saunders | Justin Duchscherer | Francisco Rodriguez | Huston Street | 17 | 15 | 2 |
| 2007-04-06 | @ ANA | 5 | L 2-5 | 2-3 | 3 | 43,534 | Joe Kennedy | Dustin Moseley | Dustin Moseley | Joe Kennedy | Francisco Rodriguez | 19 | 20 | -1 |
| 2007-04-07 | @ ANA | 6 | L 1-2 | 2-4 | 4 | 44,007 | Dan Haren | John Lackey | John Lackey | Dan Haren | Scot Shields | 20 | 22 | -2 |
| 2007-04-08 | @ ANA | 7 | W 2-1 | 3-4 | 3 | 37,783 | Joe Blanton | Kelvim Escobar | Joe Blanton | Kelvim Escobar | Huston Street | 22 | 23 | -1 |
| 2007-04-09 | vs CHA | 8 | L 1-4 | 3-5 | 4 | 35,077 | Rich Harden | Jose Contreras | Jose Contreras | Rich Harden | | 23 | 27 | -4 |
| 2007-04-10 | vs CHA | 9 | W 2-1 | 4-5 | 4 | 15,153 | Chad Gaudin | Jon Garland | Huston Street | Bobby Jenks | | 25 | 28 | -3 |
| 2007-04-11 | vs CHA | 10 | L 3-6 | 4-6 | 4 | 19,130 | Joe Kennedy | Mark Buehrle | David Aardsma | Huston Street | Bobby Jenks | 28 | 34 | -6 |
| 2007-04-13 | vs NYA | 11 | W 5-4 | 5-6 | 4 | 35,077 | Dan Haren | Kei Igawa | Huston Street | Brian Bruney | | 33 | 38 | -5 |
| 2007-04-14 | vs NYA | 12 | L 3-4 | 5-7 | 4 | 35,077 | Joe Blanton | Darrell Rasner | Brian Bruney | Lenny DiNardo | | 36 | 42 | -6 |
| 2007-04-15 | vs NYA | 13 | W 5-4 | 6-7 | 3 | 35,077 | Rich Harden | Andy Pettitte | Jay Marshall | Mariano Rivera | | 41 | 46 | -5 |
| 2007-04-17 | vs ANA | 14 | W 4-1 | 7-7 | 2 | 20,174 | Chad Gaudin | Jered Weaver | Chad Gaudin | Jered Weaver | Huston Street | 45 | 47 | -2 |
| 2007-04-18 | vs ANA | 15 | W 3-0 | 8-7 | 1 | 17,322 | Dan Haren | John Lackey | Dan Haren | John Lackey | Huston Street | 48 | 47 | 1 |
| 2007-04-20 | @ TEX | 16 | W 16-4 | 9-7 | 1 | 29,782 | Joe Blanton | Brandon McCarthy | Joe Blanton | Brandon McCarthy | | 64 | 51 | 13 |
| 2007-04-21 | @ TEX | 17 | L 0-7 | 9-8 | 1 | 42,945 | Joe Kennedy | Kameron Loe | Kameron Loe | Joe Kennedy | | 64 | 58 | 6 |
| 2007-04-22 | @ TEX | 18 | L 3-4 | 9-9 | 1 | 37,002 | Chad Gaudin | Rob Tejeda | Willie Eyre | Justin Duchscherer | Akinori Otsuka | 67 | 62 | 5 |
| 2007-04-23 | @ BAL | 19 | W 6-5 | 10-9 | 1 | 13,862 | Dan Haren | Erik Bedard | Dan Haren | Erik Bedard | Huston Street | 73 | 67 | 6 |
| 2007-04-24 | @ BAL | 20 | W 4-2 | 11-9 | 1 | 14,452 | Dallas Braden | Jeremy Guthrie | Dallas Braden | Jeremy Guthrie | Huston Street | 77 | 69 | 8 |
| 2007-04-25 | vs SEA | 21 | L 0-2 | 11-10 | 1 | 19,674 | Joe Blanton | Jarrod Washburn | Jarrod Washburn | Joe Blanton | | 77 | 71 | 6 |
| 2007-04-26 | vs SEA | 22 | L 2-4 | 11-11 | 2 | 14,683 | Joe Kennedy | Miguel Batista | Miguel Batista | Kiko Calero | J.J. Putz | 79 | 75 | 4 |
| 2007-04-27 | vs TBA | 23 | L 1-4 | 11-12 | 3 | 15,388 | Chad Gaudin | James Shields | James Shields | Chad Gaudin | Alberto Reyes | 80 | 79 | 1 |
| 2007-04-28 | vs TBA | 24 | W 12-5 | 12-12 | 2 | 26,760 | Dan Haren | Casey Fossum | Dan Haren | Casey Fossum | | 92 | 84 | 8 |
| 2007-04-29 | vs TBA | 25 | L 3-5 | 12-13 | 3 | 23,827 | Dallas Braden | Scott Kazmir | Scott Kazmir | Dallas Braden | Alberto Reyes | 95 | 89 | 6 |
| 2007-05-01 | @ BOS | 26 | W 5-4 | 13-13 | 3 | 37,052 | Joe Blanton | Curt Schilling | Justin Duchscherer | Brendan Donnelly | Huston Street | 100 | 93 | 7 |
| 2007-05-02 | @ BOS | 27 | L 4-6 | 13-14 | 3 | 37,006 | Chad Gaudin | Josh Beckett | Josh Beckett | Jay Marshall | Mike Timlin | 104 | 99 | 5 |
| 2007-05-04 | @ TBA | 28 | W 5-2 | 14-14 | 3 | 11,546 | Dan Haren | Casey Fossum | Justin Duchscherer | Gary Glover | Huston Street | 109 | 101 | 8 |
| 2007-05-05 | @ TBA | 29 | L 2-3 | 14-15 | 3 | 16,604 | Joe Kennedy | Scott Kazmir | Ruddy Lugo | Jay Marshall | | 111 | 104 | 7 |
| 2007-05-06 | @ TBA | 30 | W 5-3 | 15-15 | 2 | 16,880 | Joe Blanton | Edwin Jackson | Joe Blanton | Edwin Jackson | Huston Street | 116 | 107 | 9 |
| 2007-05-08 | @ KCA | 31 | W 6-1 | 16-15 | 1 | 10,989 | Chad Gaudin | Jorge de la Rosa | Chad Gaudin | Jorge de la Rosa | | 122 | 108 | 14 |
| 2007-05-09 | @ KCA | 32 | L 2-3 | 16-16 | 3 | 10,974 | Dan Haren | Gil Meche | Jimmy Gobble | Justin Duchscherer | Joakim Soria | 124 | 111 | 13 |
| 2007-05-10 | @ KCA | 33 | W 17-3 | 17-16 | 2 | 31,006 | Joe Kennedy | Luke Hudson | Joe Kennedy | Luke Hudson | | 141 | 114 | 27 |
| 2007-05-11 | vs CLE | 34 | W 8-2 | 18-16 | 2 | 20,393 | Joe Blanton | CC Sabathia | Joe Blanton | CC Sabathia | | 149 | 116 | 33 |
| 2007-05-12 | vs CLE | 35 | L 3-6 | 18-17 | 2 | 22,705 | Dallas Braden | Fausto Carmona | Fausto Carmona | Dallas Braden | Joe Borowski | 152 | 122 | 30 |
| 2007-05-13 | vs CLE | 36 | W 10-7 | 19-17 | 2 | 24,692 | Chad Gaudin | Cliff Lee | Jay Witasick | Joe Borowski | | 162 | 129 | 33 |
| 2007-05-14 | vs KCA | 37 | L 1-2 | 19-18 | 3 | 12,477 | Dan Haren | Gil Meche | Jimmy Gobble | Justin Duchscherer | Joakim Soria | 163 | 131 | 32 |
| 2007-05-15 | vs KCA | 38 | W 5-4 | 20-18 | 3 | 14,966 | Joe Kennedy | Brian Bannister | Lenny DiNardo | Joakim Soria | | 168 | 135 | 33 |
| 2007-05-16 | vs KCA | 39 | L 3-4 | 20-19 | 3 | 16,242 | Joe Blanton | Odalis Perez | Jimmy Gobble | Kiko Calero | David Riske | 171 | 139 | 32 |
| 2007-05-17 | vs KCA | 40 | L 4-7 | 20-20 | 2 | 21,037 | Dallas Braden | Scott Elarton | Scott Elarton | Dallas Braden | Joakim Soria | 175 | 146 | 29 |
| 2007-05-18 | vs SFN | 41 | W 15-3 | 21-20 | 2 | 35,077 | Chad Gaudin | Barry Zito | Chad Gaudin | Barry Zito | | 190 | 149 | 41 |
| 2007-05-19 | vs SFN | 42 | W 4-2 | 22-20 | 2 | 35,077 | Dan Haren | Matt Cain | Dan Haren | Matt Cain | Alan Embree | 194 | 151 | 43 |
| 2007-05-20 | vs SFN | 43 | L 1-4 | 22-21 | 2 | 35,077 | Joe Kennedy | Matt Morris | Matt Morris | Joe Kennedy | | 195 | 155 | 40 |
| 2007-05-21 | @ CHA | 44 | L 5-8 | 22-22 | 2 | 35,327 | Joe Blanton | Jose Contreras | Jose Contreras | Joe Blanton | Bobby Jenks | 200 | 163 | 37 |
| 2007-05-22 | @ CHA | 45 | L 4-10 | 22-23 | 2 | 34,122 | Colby Lewis | John Danks | John Danks | Colby Lewis | | 204 | 173 | 31 |
| 2007-05-23 | @ CHA | 46 | W 4-0 | 23-23 | 2 | 29,051 | Chad Gaudin | Jon Garland | Chad Gaudin | Jon Garland | | 208 | 173 | 35 |
| 2007-05-25 | @ BAL | 47 | W 3-2 | 24-23 | 2 | 30,382 | Dan Haren | Erik Bedard | Dan Haren | Erik Bedard | Alan Embree | 211 | 175 | 36 |
| 2007-05-26 | @ BAL | 48 | L 3-8 | 24-24 | 3 | 29,194 | Joe Kennedy | Brian Burres | Brian Burres | Joe Kennedy | | 214 | 183 | 31 |
| 2007-05-27 | @ BAL | 49 | L 4-8 | 24-25 | 3 | 30,140 | Joe Blanton | Daniel Cabrera | Daniel Cabrera | Joe Blanton | | 218 | 191 | 27 |
| 2007-05-28 | vs TEX | 50 | W 5-3 | 25-25 | 3 | 18,230 | Chad Gaudin | Rob Tejeda | Chad Gaudin | Rob Tejeda | Alan Embree | 223 | 194 | 29 |
| 2007-05-29 | vs TEX | 51 | L 0-4 | 25-26 | 3 | 18,006 | Lenny DiNardo | Mike Wood | Mike Wood | Lenny DiNardo | Eric Gagne | 223 | 198 | 25 |
| 2007-05-30 | vs TEX | 52 | W 6-1 | 26-26 | 3 | 25,674 | Dan Haren | John Koronka | Dan Haren | John Koronka | | 229 | 199 | 30 |
| 2007-06-01 | vs MIN | 53 | L 2-3 | 26-27 | 3 | 20,219 | Joe Kennedy | Kevin Slowey | Pat Neshek | Kiko Calero | Joe Nathan | 231 | 202 | 29 |
| 2007-06-02 | vs MIN | 54 | W 1-0 | 27-27 | 3 | 30,576 | Joe Blanton | Carlos Silva | Joe Blanton | Carlos Silva | | 232 | 202 | 30 |
| 2007-06-03 | vs MIN | 55 | W 4-2 | 28-27 | 3 | 25,388 | Chad Gaudin | Johan Santana | Chad Gaudin | Johan Santana | Alan Embree | 236 | 204 | 32 |
| 2007-06-04 | vs BOS | 56 | W 5-4 | 29-27 | 3 | 28,177 | Dan Haren | Julian Tavarez | Santiago Casilla | Kyle Snyder | | 241 | 208 | 33 |
| 2007-06-05 | vs BOS | 57 | W 2-0 | 30-27 | 3 | 31,127 | Lenny DiNardo | Daisuke Matsuzaka | Lenny DiNardo | Daisuke Matsuzaka | Alan Embree | 243 | 208 | 35 |
| 2007-06-06 | vs BOS | 58 | W 3-2 | 31-27 | 3 | 32,280 | Joe Kennedy | Tim Wakefield | Joe Kennedy | Tim Wakefield | Santiago Casilla | 246 | 210 | 36 |
| 2007-06-07 | vs BOS | 59 | L 0-1 | 31-28 | 3 | 31,211 | Joe Blanton | Curt Schilling | Curt Schilling | Joe Blanton | | 246 | 211 | 35 |
| 2007-06-08 | @ SFN | 60 | W 5-3 | 32-28 | 3 | 42,427 | Chad Gaudin | Tim Lincecum | Kiko Calero | Brad Hennessey | Alan Embree | 251 | 214 | 37 |
| 2007-06-09 | @ SFN | 61 | W 6-0 | 33-28 | 3 | 42,526 | Dan Haren | Barry Zito | Dan Haren | Barry Zito | | 257 | 214 | 43 |
| 2007-06-10 | @ SFN | 62 | W 2-0 | 34-28 | 3 | 42,345 | Lenny DiNardo | Matt Cain | Santiago Casilla | Matt Cain | Alan Embree | 259 | 214 | 45 |
| 2007-06-12 | @ HOU | 63 | L 4-5 | 34-29 | 3 | 33,637 | Joe Kennedy | Roy Oswalt | Dave Borkowski | Ron Flores | | 263 | 219 | 44 |
| 2007-06-13 | @ HOU | 64 | W 7-3 | 35-29 | 3 | 34,611 | Joe Blanton | Chris Sampson | Joe Blanton | Dan Wheeler | | 270 | 222 | 48 |
| 2007-06-14 | @ HOU | 65 | W 6-5 | 36-29 | 3 | 42,024 | Chad Gaudin | Jason Jennings | Alan Embree | Brian Moehler | Santiago Casilla | 276 | 227 | 49 |
| 2007-06-15 | vs SLN | 66 | W 14-3 | 37-29 | 2 | 24,241 | Dan Haren | Braden Looper | Dan Haren | Braden Looper | | 290 | 230 | 60 |
| 2007-06-16 | vs SLN | 67 | L 6-15 | 37-30 | 2 | 28,572 | Lenny DiNardo | Todd Wellemeyer | Russ Springer | Lenny DiNardo | | 296 | 245 | 51 |
| 2007-06-17 | vs SLN | 68 | L 6-10 | 37-31 | 2 | 35,077 | Joe Kennedy | Anthony Reyes | Russ Springer | Colby Lewis | | 302 | 255 | 47 |
| 2007-06-18 | vs CIN | 69 | W 6-1 | 38-31 | 2 | 16,466 | Joe Blanton | Kyle Lohse | Joe Blanton | Kyle Lohse | | 308 | 256 | 52 |
| 2007-06-19 | vs CIN | 70 | L 2-5 | 38-32 | 2 | 19,351 | Chad Gaudin | Homer Bailey | Homer Bailey | Chad Gaudin | David Weathers | 310 | 261 | 49 |
| 2007-06-20 | vs CIN | 71 | W 5-3 | 39-32 | 2 | 25,872 | Dan Haren | Matt Belisle | Dan Haren | Marcus McBeth | Alan Embree | 315 | 264 | 51 |
| 2007-06-22 | @ NYN | 72 | L 1-9 | 39-33 | 2 | 43,029 | Lenny DiNardo | Tom Glavine | Tom Glavine | Lenny DiNardo | | 316 | 273 | 43 |
| 2007-06-23 | @ NYN | 73 | L 0-1 | 39-34 | 3 | 52,920 | Joe Blanton | Orlando Hernandez | Billy Wagner | Santiago Casilla | | 316 | 274 | 42 |
| 2007-06-24 | @ NYN | 74 | L 2-10 | 39-35 | 3 | 50,143 | Joe Kennedy | John Maine | John Maine | Joe Kennedy | | 318 | 284 | 34 |
| 2007-06-25 | @ CLE | 75 | L 2-5 | 39-36 | 3 | 17,737 | Chad Gaudin | CC Sabathia | CC Sabathia | Chad Gaudin | | 320 | 289 | 31 |
| 2007-06-26 | @ CLE | 76 | L 5-8 | 39-37 | 3 | 18,494 | Dan Haren | Cliff Lee | Rafael Betancourt | Alan Embree | | 325 | 297 | 28 |
| 2007-06-27 | @ CLE | 77 | W 13-7 | 40-37 | 3 | 18,614 | Lenny DiNardo | Fausto Carmona | Lenny DiNardo | Fausto Carmona | | 338 | 304 | 34 |
| 2007-06-28 | @ CLE | 78 | L 3-4 | 40-38 | 3 | 22,921 | Joe Blanton | Paul Byrd | Paul Byrd | Ron Flores | Joe Borowski | 341 | 308 | 33 |
| 2007-06-29 | @ NYA | 79 | L 1-2 | 40-39 | 3 | 52,622 | Joe Kennedy | Mike Mussina | Mike Mussina | Joe Kennedy | Mariano Rivera | 342 | 310 | 32 |
| 2007-06-30 | @ NYA | 80 | W 7-0 | 41-39 | 3 | 54,150 | Chad Gaudin | Kei Igawa | Chad Gaudin | Kei Igawa | | 349 | 310 | 39 |
| 2007-07-01 | @ NYA | 81 | W 11-5 | 42-39 | 3 | 54,266 | Dan Haren | Andy Pettitte | Dan Haren | Andy Pettitte | | 360 | 315 | 45 |
| 2007-07-02 | vs TOR | 82 | L 7-11 | 42-40 | 3 | 13,281 | Lenny DiNardo | Josh Towers | Josh Towers | Lenny DiNardo | | 367 | 326 | 41 |
| 2007-07-03 | vs TOR | 83 | W 3-1 | 43-40 | 3 | 35,077 | Joe Blanton | Jesse Litsch | Joe Blanton | Jesse Litsch | | 370 | 327 | 43 |
| 2007-07-04 | vs TOR | 84 | L 3-10 | 43-41 | 3 | 26,566 | Joe Kennedy | Dustin McGowan | Dustin McGowan | Joe Kennedy | | 373 | 337 | 36 |
| 2007-07-05 | vs SEA | 85 | W 3-2 | 44-41 | 3 | 15,654 | Chad Gaudin | Miguel Batista | Chad Gaudin | Miguel Batista | Alan Embree | 376 | 339 | 37 |
| 2007-07-06 | vs SEA | 86 | L 1-7 | 44-42 | 3 | 19,158 | Dan Haren | Jeff Weaver | Eric O'Flaherty | Dan Haren | | 377 | 346 | 31 |
| 2007-07-07 | vs SEA | 87 | L 0-4 | 44-43 | 3 | 29,225 | Rich Harden | Felix Hernandez | Felix Hernandez | Rich Harden | | 377 | 350 | 27 |
| 2007-07-08 | vs SEA | 88 | L 3-7 | 44-44 | 3 | 27,059 | Joe Blanton | Ryan Feierabend | Sean Green | Joe Blanton | | 380 | 357 | 23 |
| 2007-07-12 | @ MIN | 89 | L 2-6 | 44-45 | 3 | 25,207 | Chad Gaudin | Scott Baker | Scott Baker | Chad Gaudin | | 382 | 363 | 19 |
| 2007-07-13 | @ MIN | 90 | L 3-5 | 44-46 | 3 | 36,338 | Lenny DiNardo | Johan Santana | Johan Santana | Lenny DiNardo | Joe Nathan | 385 | 368 | 17 |
| 2007-07-14 | @ MIN | 91 | L 3-4 | 44-47 | 3 | 36,066 | Joe Blanton | Carlos Silva | Carlos Silva | Joe Blanton | Joe Nathan | 388 | 372 | 16 |
| 2007-07-15 | @ MIN | 92 | L 3-4 | 44-48 | 3 | 36,737 | Dan Haren | Boof Bonser | Pat Neshek | Joe Kennedy | | 391 | 376 | 15 |
| 2007-07-16 | vs TEX | 93 | L 1-4 | 44-49 | 3 | 18,160 | Dallas Braden | Jamey Wright | Jamey Wright | Dallas Braden | Eric Gagne | 392 | 380 | 12 |
| 2007-07-17 | vs TEX | 94 | L 4-11 | 44-50 | 3 | 20,209 | Chad Gaudin | Rob Tejeda | Willie Eyre | Chad Gaudin | Ron Mahay | 396 | 391 | 5 |
| 2007-07-18 | vs TEX | 95 | W 6-0 | 45-50 | 3 | 23,440 | Lenny DiNardo | Kevin Millwood | Lenny DiNardo | Kevin Millwood | | 402 | 391 | 11 |
| 2007-07-20 | vs BAL | 96 | L 1-6 | 45-51 | 3 | 18,444 | Joe Blanton | Erik Bedard | Erik Bedard | Joe Blanton | | 403 | 397 | 6 |
| 2007-07-21 | vs BAL | 97 | W 4-3 | 46-51 | 3 | 30,828 | Dan Haren | Steve Trachsel | Dan Haren | Steve Trachsel | Alan Embree | 407 | 400 | 7 |
| 2007-07-22 | vs BAL | 98 | L 0-2 | 46-52 | 3 | 25,552 | Dallas Braden | Jeremy Guthrie | Jeremy Guthrie | Dallas Braden | Jamie Walker | 407 | 402 | 5 |
| 2007-07-23 | @ ANA | 99 | W 12-6 | 47-52 | 3 | 43,847 | Chad Gaudin | Bartolo Colon | Joe Kennedy | Bartolo Colon | | 419 | 408 | 11 |
| 2007-07-24 | @ ANA | 100 | W 4-3 | 48-52 | 3 | 43,784 | Lenny DiNardo | Kelvim Escobar | Lenny DiNardo | Kelvim Escobar | Alan Embree | 423 | 411 | 12 |
| 2007-07-25 | @ ANA | 101 | L 6-7 | 48-53 | 3 | 44,252 | Joe Blanton | John Lackey | Francisco Rodriguez | Joe Kennedy | | 429 | 418 | 11 |
| 2007-07-26 | @ SEA | 102 | W 6-2 | 49-53 | 3 | 34,250 | Dan Haren | Jeff Weaver | Dan Haren | Jeff Weaver | | 435 | 420 | 15 |
| 2007-07-27 | @ SEA | 103 | L 1-7 | 49-54 | 3 | 37,643 | Dallas Braden | Felix Hernandez | Felix Hernandez | Dallas Braden | | 436 | 427 | 9 |
| 2007-07-28 | @ SEA | 104 | L 3-4 | 49-55 | 3 | 41,260 | Chad Gaudin | Horacio Ramirez | Horacio Ramirez | Chad Gaudin | J.J. Putz | 439 | 431 | 8 |
| 2007-07-29 | @ SEA | 105 | L 10-14 | 49-56 | 3 | 41,961 | Lenny DiNardo | Jarrod Washburn | Sean Green | Huston Street | | 449 | 445 | 4 |
| 2007-07-30 | vs DET | 106 | L 2-5 | 49-57 | 3 | 18,468 | Joe Blanton | Jordan Tata | Jordan Tata | Joe Blanton | Todd Jones | 451 | 450 | 1 |
| 2007-07-31 | vs DET | 107 | W 7-3 | 50-57 | 3 | 21,305 | Dan Haren | Justin Verlander | Dan Haren | Justin Verlander | | 458 | 453 | 5 |
| 2007-08-01 | vs DET | 108 | W 3-2 | 51-57 | 3 | 27,118 | Dallas Braden | Nate Robertson | Andrew Brown | Nate Robertson | Alan Embree | 461 | 455 | 6 |
| 2007-08-02 | vs ANA | 109 | L 4-6 | 51-58 | 3 | 21,654 | Chad Gaudin | Joe Saunders | Joe Saunders | Chad Gaudin | Francisco Rodriguez | 465 | 461 | 4 |
| 2007-08-03 | vs ANA | 110 | W 8-4 | 52-58 | 3 | 21,552 | Lenny DiNardo | Dustin Moseley | Santiago Casilla | Scot Shields | | 473 | 465 | 8 |
| 2007-08-04 | vs ANA | 111 | W 2-1 | 53-58 | 3 | 29,144 | Joe Blanton | Kelvim Escobar | Joe Blanton | Kelvim Escobar | Alan Embree | 475 | 466 | 9 |
| 2007-08-05 | vs ANA | 112 | L 3-4 | 53-59 | 3 | 26,782 | Dan Haren | John Lackey | John Lackey | Kiko Calero | Francisco Rodriguez | 478 | 470 | 8 |
| 2007-08-06 | @ TEX | 113 | W 9-7 | 54-59 | 3 | 24,737 | Dallas Braden | John Rheinecker | Andrew Brown | Willie Eyre | Kiko Calero | 487 | 477 | 10 |
| 2007-08-07 | @ TEX | 114 | L 6-8 | 54-60 | 3 | 25,122 | Chad Gaudin | Kason Gabbard | Kason Gabbard | Chad Gaudin | C.J. Wilson | 493 | 485 | 8 |
| 2007-08-08 | @ TEX | 115 | W 6-3 | 55-60 | 3 | 29,647 | Lenny DiNardo | Kevin Millwood | Lenny DiNardo | A.J. Murray | Alan Embree | 499 | 488 | 11 |
| 2007-08-10 | @ DET | 116 | W 16-10 | 56-60 | 3 | 40,922 | Joe Blanton | Jordan Tata | Ruddy Lugo | Macay McBride | | 515 | 498 | 17 |
| 2007-08-11 | @ DET | 117 | L 2-5 | 56-61 | 3 | 42,016 | Dan Haren | Justin Verlander | Justin Verlander | Dan Haren | Todd Jones | 517 | 503 | 14 |
| 2007-08-12 | @ DET | 118 | L 6-11 | 56-62 | 3 | 39,960 | Dallas Braden | Nate Robertson | Nate Robertson | Dallas Braden | | 523 | 514 | 9 |
| 2007-08-13 | @ DET | 119 | W 7-2 | 57-62 | 3 | 37,229 | Chad Gaudin | Chad Durbin | Chad Gaudin | Chad Durbin | | 530 | 516 | 14 |
| 2007-08-14 | vs CHA | 120 | W 4-3 | 58-62 | 3 | 24,082 | Lenny DiNardo | Jon Garland | Lenny DiNardo | Jon Garland | Alan Embree | 534 | 519 | 15 |
| 2007-08-15 | vs CHA | 121 | W 3-2 | 59-62 | 3 | 25,295 | Joe Blanton | Mark Buehrle | Joe Blanton | Mark Buehrle | Huston Street | 537 | 521 | 16 |
| 2007-08-16 | vs CHA | 122 | W 8-5 | 60-62 | 3 | 20,218 | Dan Haren | Javier Vazquez | Ruddy Lugo | Matt Thornton | | 545 | 526 | 19 |
| 2007-08-17 | vs KCA | 123 | L 2-9 | 60-63 | 3 | 18,185 | Dan Meyer | Brian Bannister | Brian Bannister | Dan Meyer | | 547 | 535 | 12 |
| 2007-08-18 | vs KCA | 124 | L 3-7 | 60-64 | 3 | 24,638 | Chad Gaudin | Odalis Perez | Odalis Perez | Chad Gaudin | | 550 | 542 | 8 |
| 2007-08-19 | vs KCA | 125 | W 6-1 | 61-64 | 3 | 26,445 | Lenny DiNardo | Kyle Davies | Lenny DiNardo | Kyle Davies | | 556 | 543 | 13 |
| 2007-08-20 | @ TOR | 126 | W 6-4 | 62-64 | 3 | 27,193 | Joe Blanton | Shaun Marcum | Joe Blanton | Shaun Marcum | Huston Street | 562 | 547 | 15 |
| 2007-08-21 | @ TOR | 127 | W 6-4 | 63-64 | 3 | 32,639 | Dan Haren | Dustin McGowan | Dan Haren | Brian Tallet | Huston Street | 568 | 551 | 17 |
| 2007-08-22 | @ TOR | 128 | W 4-1 | 64-64 | 3 | 31,145 | Esteban Loaiza | A.J. Burnett | Esteban Loaiza | A.J. Burnett | Alan Embree | 572 | 552 | 20 |
| 2007-08-23 | @ TBA | 129 | W 12-2 | 65-64 | 3 | 9,444 | Chad Gaudin | Jason Hammel | Chad Gaudin | Jason Hammel | | 584 | 554 | 30 |
| 2007-08-24 | @ TBA | 130 | L 2-12 | 65-65 | 3 | 9,592 | Lenny DiNardo | James Shields | James Shields | Lenny DiNardo | | 586 | 566 | 20 |
| 2007-08-25 | @ TBA | 131 | L 3-14 | 65-66 | 3 | 18,163 | Joe Blanton | Scott Kazmir | Scott Kazmir | Joe Blanton | | 589 | 580 | 9 |
| 2007-08-26 | @ TBA | 132 | L 4-7 | 65-67 | 3 | 19,044 | Dan Haren | Andy Sonnanstine | Andy Sonnanstine | Dan Haren | Alberto Reyes | 593 | 587 | 6 |
| 2007-08-27 | vs TOR | 133 | L 2-6 | 65-68 | 3 | 18,092 | Esteban Loaiza | A.J. Burnett | Jeremy Accardo | Alan Embree | | 595 | 593 | 2 |
| 2007-08-28 | vs TOR | 134 | L 4-5 | 65-69 | 3 | 20,542 | Chad Gaudin | Jesse Litsch | Brian Wolfe | Andrew Brown | Casey Janssen | 599 | 598 | 1 |
| 2007-08-29 | vs TOR | 135 | W 5-4 | 66-69 | 3 | 16,015 | Lenny DiNardo | Roy Halladay | Ruddy Lugo | Jason Frasor | | 604 | 602 | 2 |
| 2007-08-31 | vs DET | 136 | W 5-4 | 67-69 | 3 | 27,250 | Joe Blanton | Virgil Vasquez | Huston Street | Joel Zumaya | | 609 | 606 | 3 |
| 2007-09-01 | vs DET | 137 | L 1-6 | 67-70 | 3 | 21,336 | Dan Haren | Justin Verlander | Justin Verlander | Dan Haren | | 610 | 612 | -2 |
| 2007-09-02 | vs DET | 138 | W 8-7 | 68-70 | 3 | 23,195 | Dallas Braden | Nate Robertson | Huston Street | Yorman Bazardo | | 618 | 619 | -1 |
| 2007-09-03 | @ ANA | 139 | L 5-9 | 68-71 | 3 | 39,164 | Chad Gaudin | Ervin Santana | Ervin Santana | Chad Gaudin | | 623 | 628 | -5 |
| 2007-09-04 | @ ANA | 140 | L 3-4 | 68-72 | 3 | 39,017 | Lenny DiNardo | Jered Weaver | Jered Weaver | Lenny DiNardo | Francisco Rodriguez | 626 | 632 | -6 |
| 2007-09-05 | @ ANA | 141 | W 6-2 | 69-72 | 3 | 34,000 | Joe Blanton | Joe Saunders | Joe Blanton | Joe Saunders | | 632 | 634 | -2 |
| 2007-09-07 | @ TEX | 142 | L 3-5 | 69-73 | 3 | 22,318 | Dan Haren | Edinson Volquez | Edinson Volquez | Dan Haren | Joaquin Benoit | 635 | 639 | -4 |
| 2007-09-08 | @ TEX | 143 | L 3-7 | 69-74 | 3 | 32,476 | Chad Gaudin | Luis Mendoza | A.J. Murray | Chad Gaudin | | 638 | 646 | -8 |
| 2007-09-09 | @ TEX | 144 | L 9-12 | 69-75 | 3 | 25,054 | Lenny DiNardo | Kevin Millwood | Bill White | Lenny DiNardo | | 647 | 658 | -11 |
| 2007-09-10 | @ SEA | 145 | W 9-3 | 70-75 | 3 | 26,698 | Joe Blanton | Horacio Ramirez | Joe Blanton | Horacio Ramirez | Huston Street | 656 | 661 | -5 |
| 2007-09-11 | @ SEA | 146 | W 7-4 | 71-75 | 3 | 26,676 | Dallas Braden | Jarrod Washburn | Ruddy Lugo | Jarrod Washburn | Huston Street | 663 | 665 | -2 |
| 2007-09-12 | @ SEA | 147 | L 5-6 | 71-76 | 3 | 26,194 | Dan Haren | Miguel Batista | J.J. Putz | Andrew Brown | | 668 | 671 | -3 |
| 2007-09-13 | vs TEX | 148 | W 6-5 | 72-76 | 3 | 16,240 | Chad Gaudin | Kevin Millwood | Chad Gaudin | Kevin Millwood | Huston Street | 674 | 676 | -2 |
| 2007-09-14 | vs TEX | 149 | W 11-9 | 73-76 | 3 | 19,346 | Dan Meyer | Kason Gabbard | Andrew Brown | John Rheinecker | Huston Street | 685 | 685 | 0 |
| 2007-09-15 | vs TEX | 150 | W 7-3 | 74-76 | 3 | 24,517 | Joe Blanton | Brandon McCarthy | Joe Blanton | Brandon McCarthy | Alan Embree | 692 | 688 | 4 |
| 2007-09-16 | vs TEX | 151 | L 9-11 | 74-77 | 3 | 23,770 | Lenny DiNardo | Vicente Padilla | John Rheinecker | Andrew Brown | Joaquin Benoit | 701 | 699 | 2 |
| 2007-09-17 | vs SEA | 152 | L 0-4 | 74-78 | 3 | 17,228 | Dan Haren | Miguel Batista | Miguel Batista | Dan Haren | | 701 | 703 | -2 |
| 2007-09-18 | vs SEA | 153 | L 7-8 | 74-79 | 3 | 18,145 | Chad Gaudin | Jeff Weaver | Jeff Weaver | Chad Gaudin | George Sherrill | 708 | 711 | -3 |
| 2007-09-19 | vs SEA | 154 | L 5-9 | 74-80 | 3 | 21,171 | Dan Meyer | Felix Hernandez | Felix Hernandez | Dan Meyer | | 713 | 720 | -7 |
| 2007-09-21 | @ CLE | 155 | L 3-4 | 74-81 | 3 | 36,016 | Joe Blanton | Fausto Carmona | Fausto Carmona | Joe Blanton | Joe Borowski | 716 | 724 | -8 |
| 2007-09-22 | @ CLE | 156 | W 9-3 | 75-81 | 3 | 40,663 | Dan Haren | Paul Byrd | Dan Haren | Paul Byrd | | 725 | 727 | -2 |
| 2007-09-23 | @ CLE | 157 | L 2-6 | 75-82 | 3 | 40,250 | Dallas Braden | Jake Westbrook | Jake Westbrook | Dallas Braden | Rafael Betancourt | 727 | 733 | -6 |
| 2007-09-25 | @ BOS | 158 | L 3-7 | 75-83 | 3 | 36,708 | Chad Gaudin | Curt Schilling | Curt Schilling | Chad Gaudin | | 730 | 740 | -10 |
| 2007-09-26 | @ BOS | 159 | L 6-11 | 75-84 | 3 | 36,570 | Joe Blanton | Jon Lester | Mike Timlin | Jerry Blevins | | 736 | 751 | -15 |
| 2007-09-28 | vs ANA | 160 | L 0-2 | 75-85 | 3 | 32,287 | Dan Haren | John Lackey | John Lackey | Dan Haren | Francisco Rodriguez | 736 | 753 | -17 |
| 2007-09-29 | vs ANA | 161 | L 2-3 | 75-86 | 3 | 26,480 | Dallas Braden | Kelvim Escobar | Kelvim Escobar | Lenny DiNardo | Francisco Rodriguez | 738 | 756 | -18 |
| 2007-09-30 | vs ANA | 162 | W 3-2 | 76-86 | 3 | 28,062 | Chad Gaudin | Jered Weaver | Huston Street | Chris Bootcheck | | 741 | 758 | -17 |