| 2007-04-02 | vs TBA | 1 | W 9-5 | 1-0 | 1 | 55,035 | Carl Pavano | Scott Kazmir | Luis Vizcaino | Brian Stokes | | 9 | 5 | 4 |
| 2007-04-05 | vs TBA | 2 | L 6-7 | 1-1 | 2 | 52,096 | Andy Pettitte | Jae Weong Seo | Ruddy Lugo | Luis Vizcaino | Alberto Reyes | 15 | 12 | 3 |
| 2007-04-06 | vs BAL | 3 | L 4-6 | 1-2 | 3 | 50,074 | Mike Mussina | Adam Loewen | Adam Loewen | Mike Mussina | Chris Ray | 19 | 18 | 1 |
| 2007-04-07 | vs BAL | 4 | W 10-7 | 2-2 | 1 | 50,510 | Kei Igawa | Steve Trachsel | Mariano Rivera | Chris Ray | | 29 | 25 | 4 |
| 2007-04-08 | vs BAL | 5 | L 4-6 | 2-3 | 3 | 47,679 | Darrell Rasner | Erik Bedard | Erik Bedard | Darrell Rasner | Chris Ray | 33 | 31 | 2 |
| 2007-04-09 | @ MIN | 6 | W 8-2 | 3-3 | 3 | 26,047 | Carl Pavano | Sidney Ponson | Carl Pavano | Sidney Ponson | | 41 | 33 | 8 |
| 2007-04-10 | @ MIN | 7 | W 10-1 | 4-3 | 2 | 24,552 | Andy Pettitte | Boof Bonser | Andy Pettitte | Boof Bonser | | 51 | 34 | 17 |
| 2007-04-11 | @ MIN | 8 | L 1-5 | 4-4 | 3 | 30,131 | Mike Mussina | Ramon Ortiz | Ramon Ortiz | Kyle Farnsworth | | 52 | 39 | 13 |
| 2007-04-13 | @ OAK | 9 | L 4-5 | 4-5 | 4 | 35,077 | Kei Igawa | Dan Haren | Huston Street | Brian Bruney | | 56 | 44 | 12 |
| 2007-04-14 | @ OAK | 10 | W 4-3 | 5-5 | 4 | 35,077 | Darrell Rasner | Joe Blanton | Brian Bruney | Lenny DiNardo | | 60 | 47 | 13 |
| 2007-04-15 | @ OAK | 11 | L 4-5 | 5-6 | 4 | 35,077 | Andy Pettitte | Rich Harden | Jay Marshall | Mariano Rivera | | 64 | 52 | 12 |
| 2007-04-17 | vs CLE | 12 | W 10-3 | 6-6 | 4 | 38,438 | Chase Wright | Jake Westbrook | Chase Wright | Jake Westbrook | | 74 | 55 | 19 |
| 2007-04-18 | vs CLE | 13 | W 9-2 | 7-6 | 3 | 41,379 | Kei Igawa | Jeremy Sowers | Kei Igawa | Jeremy Sowers | | 83 | 57 | 26 |
| 2007-04-19 | vs CLE | 14 | W 8-6 | 8-6 | 2 | 40,872 | Darrell Rasner | Fausto Carmona | Sean Henn | Joe Borowski | | 91 | 63 | 28 |
| 2007-04-20 | @ BOS | 15 | L 6-7 | 8-7 | 3 | 36,786 | Andy Pettitte | Curt Schilling | Kyle Snyder | Mariano Rivera | Hideki Okajima | 97 | 70 | 27 |
| 2007-04-21 | @ BOS | 16 | L 5-7 | 8-8 | 3 | 36,342 | Jeff Karstens | Josh Beckett | Josh Beckett | Jeff Karstens | Jonathan Papelbon | 102 | 77 | 25 |
| 2007-04-22 | @ BOS | 17 | L 6-7 | 8-9 | 3 | 36,905 | Chase Wright | Daisuke Matsuzaka | Daisuke Matsuzaka | Scott Proctor | Jonathan Papelbon | 108 | 84 | 24 |
| 2007-04-23 | @ TBA | 18 | L 8-10 | 8-10 | 4 | 20,409 | Kei Igawa | Casey Fossum | Casey Fossum | Kei Igawa | | 116 | 94 | 22 |
| 2007-04-24 | @ TBA | 19 | L 4-6 | 8-11 | 5 | 22,328 | Chien-Ming Wang | Scott Kazmir | Juan Salas | Chien-Ming Wang | Alberto Reyes | 120 | 100 | 20 |
| 2007-04-26 | vs TOR | 20 | L 0-6 | 8-12 | 5 | 45,118 | Phil Hughes | A.J. Burnett | A.J. Burnett | Phil Hughes | | 120 | 106 | 14 |
| 2007-04-27 | vs BOS | 21 | L 4-11 | 8-13 | 5 | 55,005 | Andy Pettitte | Daisuke Matsuzaka | Daisuke Matsuzaka | Andy Pettitte | | 124 | 117 | 7 |
| 2007-04-28 | vs BOS | 22 | W 3-1 | 9-13 | 5 | 55,026 | Jeff Karstens | Tim Wakefield | Kei Igawa | Tim Wakefield | Mariano Rivera | 127 | 118 | 9 |
| 2007-04-29 | vs BOS | 23 | L 4-7 | 9-14 | 5 | 54,856 | Chien-Ming Wang | Julian Tavarez | Julian Tavarez | Chien-Ming Wang | Jonathan Papelbon | 131 | 125 | 6 |
| 2007-05-01 | @ TEX | 24 | W 10-1 | 10-14 | 5 | 32,310 | Phil Hughes | Kameron Loe | Phil Hughes | Kameron Loe | | 141 | 126 | 15 |
| 2007-05-03 | @ TEX | 25 | W 4-3 | 11-14 | 4 | 0 | Andy Pettitte | Mike Wood | Luis Vizcaino | Joaquin Benoit | Mariano Rivera | 145 | 129 | 16 |
| 2007-05-03 | @ TEX | 26 | W 5-2 | 11-14 | 4 | 40,671 | Mike Mussina | Rob Tejeda | Mike Mussina | Rob Tejeda | Mariano Rivera | 150 | 131 | 19 |
| 2007-05-04 | vs SEA | 27 | L 11-15 | 11-15 | 5 | 49,519 | Kei Igawa | Cha-Seung Baek | Eric O'Flaherty | Colter Bean | J.J. Putz | 161 | 146 | 15 |
| 2007-05-05 | vs SEA | 28 | W 8-1 | 12-15 | 4 | 51,702 | Chien-Ming Wang | Jeff Weaver | Chien-Ming Wang | Jeff Weaver | | 169 | 147 | 22 |
| 2007-05-06 | vs SEA | 29 | W 5-0 | 13-15 | 2 | 52,553 | Darrell Rasner | Jarrod Washburn | Darrell Rasner | Jarrod Washburn | | 174 | 147 | 27 |
| 2007-05-07 | vs SEA | 30 | L 2-3 | 13-16 | 3 | 47,424 | Matt DeSalvo | Miguel Batista | George Sherrill | Mariano Rivera | J.J. Putz | 176 | 150 | 26 |
| 2007-05-08 | vs TEX | 31 | W 8-2 | 14-16 | 2 | 50,705 | Andy Pettitte | Mike Wood | Andy Pettitte | Mike Wood | | 184 | 152 | 32 |
| 2007-05-09 | vs TEX | 32 | W 6-2 | 15-16 | 2 | 47,930 | Mike Mussina | Rob Tejeda | Mike Mussina | Rob Tejeda | | 190 | 154 | 36 |
| 2007-05-10 | vs TEX | 33 | L 2-14 | 15-17 | 3 | 52,147 | Chien-Ming Wang | Brandon McCarthy | Brandon McCarthy | Chien-Ming Wang | | 192 | 168 | 24 |
| 2007-05-11 | @ SEA | 34 | L 0-3 | 15-18 | 3 | 44,214 | Darrell Rasner | Jarrod Washburn | Jarrod Washburn | Darrell Rasner | J.J. Putz | 192 | 171 | 21 |
| 2007-05-12 | @ SEA | 35 | W 7-2 | 16-18 | 3 | 46,153 | Matt DeSalvo | Miguel Batista | Matt DeSalvo | Miguel Batista | | 199 | 173 | 26 |
| 2007-05-13 | @ SEA | 36 | L 1-2 | 16-19 | 3 | 46,181 | Andy Pettitte | Horacio Ramirez | Horacio Ramirez | Andy Pettitte | J.J. Putz | 200 | 175 | 25 |
| 2007-05-16 | @ CHA | 37 | L 3-5 | 17-19 | 2 | 30,953 | Mike Mussina | John Danks | John Danks | Mike Mussina | Matt Thornton | 203 | 180 | 23 |
| 2007-05-16 | @ CHA | 38 | W 8-1 | 17-19 | 2 | 34,609 | Chien-Ming Wang | Jose Contreras | Chien-Ming Wang | Jose Contreras | | 211 | 181 | 30 |
| 2007-05-17 | @ CHA | 39 | L 1-4 | 16-21 | 5 | 30,488 | Matt DeSalvo | Jon Garland | Jon Garland | Matt DeSalvo | Bobby Jenks | 212 | 185 | 27 |
| 2007-05-18 | @ NYN | 40 | L 2-3 | 16-22 | 5 | 56,337 | Andy Pettitte | Oliver Perez | Oliver Perez | Andy Pettitte | Billy Wagner | 214 | 188 | 26 |
| 2007-05-19 | @ NYN | 41 | L 7-10 | 16-23 | 5 | 56,137 | Darrell Rasner | Tom Glavine | Tom Glavine | Darrell Rasner | | 221 | 198 | 23 |
| 2007-05-20 | @ NYN | 42 | W 6-2 | 17-23 | 4 | 56,438 | Tyler Clippard | John Maine | Tyler Clippard | John Maine | | 227 | 200 | 27 |
| 2007-05-21 | vs BOS | 43 | W 6-2 | 18-23 | 4 | 55,078 | Chien-Ming Wang | Tim Wakefield | Chien-Ming Wang | Tim Wakefield | | 233 | 202 | 31 |
| 2007-05-22 | vs BOS | 44 | L 3-7 | 18-24 | 4 | 54,739 | Mike Mussina | Julian Tavarez | Julian Tavarez | Mike Mussina | | 236 | 209 | 27 |
| 2007-05-23 | vs BOS | 45 | W 8-3 | 19-24 | 4 | 55,000 | Andy Pettitte | Curt Schilling | Andy Pettitte | Curt Schilling | | 244 | 212 | 32 |
| 2007-05-25 | vs ANA | 46 | L 6-10 | 19-25 | 4 | 50,363 | Tyler Clippard | Jered Weaver | Jered Weaver | Tyler Clippard | | 250 | 222 | 28 |
| 2007-05-26 | vs ANA | 47 | L 1-3 | 19-26 | 4 | 52,536 | Chien-Ming Wang | Kelvim Escobar | Kelvim Escobar | Chien-Ming Wang | Francisco Rodriguez | 251 | 225 | 26 |
| 2007-05-27 | vs ANA | 48 | L 3-4 | 19-27 | 5 | 53,508 | Mike Mussina | John Lackey | John Lackey | Scott Proctor | Francisco Rodriguez | 254 | 229 | 25 |
| 2007-05-28 | @ TOR | 49 | L 2-7 | 19-28 | 5 | 28,791 | Matt DeSalvo | Dustin McGowan | Dustin McGowan | Matt DeSalvo | | 256 | 236 | 20 |
| 2007-05-29 | @ TOR | 50 | L 2-3 | 19-29 | 5 | 30,116 | Andy Pettitte | Shaun Marcum | Jeremy Accardo | Andy Pettitte | | 258 | 239 | 19 |
| 2007-05-30 | @ TOR | 51 | W 10-5 | 20-29 | 5 | 29,187 | Tyler Clippard | Jesse Litsch | Tyler Clippard | Jesse Litsch | Mariano Rivera | 268 | 244 | 24 |
| 2007-06-01 | @ BOS | 52 | W 9-5 | 21-29 | 5 | 36,785 | Chien-Ming Wang | Tim Wakefield | Chien-Ming Wang | Tim Wakefield | | 277 | 249 | 28 |
| 2007-06-02 | @ BOS | 53 | L 6-11 | 21-30 | 5 | 36,294 | Mike Mussina | Curt Schilling | Hideki Okajima | Scott Proctor | | 283 | 260 | 23 |
| 2007-06-03 | @ BOS | 54 | W 6-5 | 22-30 | 5 | 36,793 | Andy Pettitte | Josh Beckett | Brian Bruney | Jonathan Papelbon | Mariano Rivera | 289 | 265 | 24 |
| 2007-06-04 | @ CHA | 55 | L 4-6 | 22-31 | 5 | 32,703 | Matt DeSalvo | Jon Garland | Jon Garland | Matt DeSalvo | Bobby Jenks | 293 | 271 | 22 |
| 2007-06-05 | @ CHA | 56 | W 7-3 | 23-31 | 5 | 30,895 | Tyler Clippard | Mark Buehrle | Tyler Clippard | Mark Buehrle | Mariano Rivera | 300 | 274 | 26 |
| 2007-06-06 | @ CHA | 57 | W 5-1 | 24-31 | 5 | 30,829 | Chien-Ming Wang | Javier Vazquez | Chien-Ming Wang | Javier Vazquez | | 305 | 275 | 30 |
| 2007-06-07 | @ CHA | 58 | W 10-3 | 25-31 | 5 | 32,688 | Mike Mussina | Jose Contreras | Scott Proctor | Jose Contreras | Mariano Rivera | 315 | 278 | 37 |
| 2007-06-08 | vs PIT | 59 | W 5-4 | 26-31 | 4 | 54,240 | Andy Pettitte | Tom Gorzelanny | Mariano Rivera | Matt Capps | | 320 | 282 | 38 |
| 2007-06-09 | vs PIT | 60 | W 9-3 | 27-31 | 4 | 54,296 | Roger Clemens | Paul Maholm | Roger Clemens | Paul Maholm | | 329 | 285 | 44 |
| 2007-06-10 | vs PIT | 61 | W 13-6 | 28-31 | 3 | 54,292 | Tyler Clippard | Shawn Chacon | Sean Henn | Shawn Chacon | | 342 | 291 | 51 |
| 2007-06-12 | vs ARI | 62 | W 4-1 | 29-31 | 2 | 51,577 | Chien-Ming Wang | Brandon Webb | Chien-Ming Wang | Brandon Webb | Mariano Rivera | 346 | 292 | 54 |
| 2007-06-13 | vs ARI | 63 | W 7-2 | 30-31 | 2 | 53,891 | Mike Mussina | Livan Hernandez | Mike Mussina | Livan Hernandez | | 353 | 294 | 59 |
| 2007-06-14 | vs ARI | 64 | W 7-1 | 31-31 | 2 | 53,712 | Andy Pettitte | Doug Davis | Andy Pettitte | Doug Davis | | 360 | 295 | 65 |
| 2007-06-15 | vs NYN | 65 | L 0-2 | 31-32 | 2 | 55,159 | Roger Clemens | Oliver Perez | Oliver Perez | Roger Clemens | Billy Wagner | 360 | 297 | 63 |
| 2007-06-16 | vs NYN | 66 | W 11-8 | 32-32 | 2 | 55,064 | Tyler Clippard | Tom Glavine | Luis Vizcaino | Tom Glavine | | 371 | 305 | 66 |
| 2007-06-17 | vs NYN | 67 | W 8-2 | 33-32 | 2 | 55,060 | Chien-Ming Wang | Orlando Hernandez | Chien-Ming Wang | Orlando Hernandez | | 379 | 307 | 72 |
| 2007-06-19 | @ COL | 68 | L 1-3 | 33-33 | 2 | 48,077 | Mike Mussina | Josh Fogg | Josh Fogg | Mike Mussina | Brian Fuentes | 380 | 310 | 70 |
| 2007-06-20 | @ COL | 69 | L 1-6 | 33-34 | 2 | 48,440 | Andy Pettitte | Jeff Francis | Jeff Francis | Andy Pettitte | | 381 | 316 | 65 |
| 2007-06-21 | @ COL | 70 | L 3-4 | 33-35 | 2 | 48,611 | Roger Clemens | Rodrigo Lopez | Rodrigo Lopez | Roger Clemens | Brian Fuentes | 384 | 320 | 64 |
| 2007-06-22 | @ SFN | 71 | W 7-3 | 34-35 | 2 | 43,425 | Kei Igawa | Matt Cain | Luis Vizcaino | Matt Cain | Mariano Rivera | 391 | 323 | 68 |
| 2007-06-23 | @ SFN | 72 | L 5-6 | 34-36 | 3 | 43,485 | Chien-Ming Wang | Matt Morris | Vinnie Chulk | Scott Proctor | | 396 | 329 | 67 |
| 2007-06-24 | @ SFN | 73 | L 2-7 | 34-37 | 3 | 43,503 | Mike Mussina | Noah Lowry | Noah Lowry | Mike Mussina | | 398 | 336 | 62 |
| 2007-06-26 | @ BAL | 74 | L 2-3 | 34-38 | 3 | 39,934 | Andy Pettitte | Jeremy Guthrie | Chris Ray | Scott Proctor | | 400 | 339 | 61 |
| 2007-06-27 | @ BAL | 75 | L 0-4 | 34-39 | 3 | 35,776 | Roger Clemens | Erik Bedard | Erik Bedard | Roger Clemens | | 400 | 343 | 57 |
| 2007-06-28 | @ BAL | 76 | W 8-7 | 35-39 | 3 | 13,496 | Chien-Ming Wang | Daniel Cabrera | Mike Myers | John Parrish | Mariano Rivera | 408 | 350 | 58 |
| 2007-06-29 | vs OAK | 77 | W 2-1 | 36-39 | 3 | 52,622 | Mike Mussina | Joe Kennedy | Mike Mussina | Joe Kennedy | Mariano Rivera | 410 | 351 | 59 |
| 2007-06-30 | vs OAK | 78 | L 0-7 | 36-40 | 3 | 54,150 | Kei Igawa | Chad Gaudin | Chad Gaudin | Kei Igawa | | 410 | 358 | 52 |
| 2007-07-01 | vs OAK | 79 | L 5-11 | 36-41 | 3 | 54,266 | Andy Pettitte | Dan Haren | Dan Haren | Andy Pettitte | | 415 | 369 | 46 |
| 2007-07-02 | vs MIN | 80 | W 5-1 | 37-41 | 3 | 53,036 | Roger Clemens | Boof Bonser | Roger Clemens | Boof Bonser | | 420 | 370 | 50 |
| 2007-07-03 | vs MIN | 81 | W 8-0 | 38-41 | 3 | 53,862 | Chien-Ming Wang | Carlos Silva | Chien-Ming Wang | Carlos Silva | | 428 | 370 | 58 |
| 2007-07-04 | vs MIN | 82 | L 2-6 | 38-42 | 3 | 52,040 | Mike Mussina | Johan Santana | Johan Santana | Mike Mussina | | 430 | 376 | 54 |
| 2007-07-05 | vs MIN | 83 | W 7-6 | 39-42 | 3 | 52,471 | Kei Igawa | Kevin Slowey | Kyle Farnsworth | Pat Neshek | Mariano Rivera | 437 | 382 | 55 |
| 2007-07-06 | vs ANA | 84 | W 14-9 | 40-42 | 3 | 52,059 | Andy Pettitte | Bartolo Colon | Edwar Ramirez | Chris Bootcheck | | 451 | 391 | 60 |
| 2007-07-07 | vs ANA | 85 | L 1-2 | 40-43 | 3 | 54,497 | Roger Clemens | John Lackey | Francisco Rodriguez | Luis Vizcaino | | 452 | 393 | 59 |
| 2007-07-08 | vs ANA | 86 | W 12-0 | 41-43 | 3 | 53,921 | Chien-Ming Wang | Ervin Santana | Chien-Ming Wang | Ervin Santana | | 464 | 393 | 71 |
| 2007-07-12 | @ TBA | 87 | W 7-3 | 42-43 | 2 | 21,907 | Andy Pettitte | James Shields | Andy Pettitte | James Shields | | 471 | 396 | 75 |
| 2007-07-13 | @ TBA | 88 | L 4-6 | 42-44 | 3 | 29,803 | Roger Clemens | Scott Kazmir | Scott Kazmir | Roger Clemens | Gary Glover | 475 | 402 | 73 |
| 2007-07-14 | @ TBA | 89 | W 6-4 | 43-44 | 2 | 36,048 | Chien-Ming Wang | Andy Sonnanstine | Chien-Ming Wang | Andy Sonnanstine | Mariano Rivera | 481 | 406 | 75 |
| 2007-07-15 | @ TBA | 90 | W 7-6 | 44-44 | 2 | 36,048 | Mike Mussina | Edwin Jackson | Luis Vizcaino | Casey Fossum | Mariano Rivera | 488 | 412 | 76 |
| 2007-07-16 | vs TOR | 91 | W 6-4 | 45-44 | 2 | 52,993 | Kei Igawa | Josh Towers | Scott Proctor | Josh Towers | Mariano Rivera | 494 | 416 | 78 |
| 2007-07-17 | vs TOR | 92 | W 3-2 | 46-44 | 2 | 51,961 | Andy Pettitte | Roy Halladay | Luis Vizcaino | Casey Janssen | | 497 | 418 | 79 |
| 2007-07-18 | vs TOR | 93 | W 6-1 | 47-44 | 2 | 52,147 | Roger Clemens | Shaun Marcum | Mike Myers | Shaun Marcum | Mariano Rivera | 503 | 419 | 84 |
| 2007-07-19 | vs TOR | 94 | L 2-3 | 47-45 | 2 | 53,857 | Chien-Ming Wang | Dustin McGowan | Dustin McGowan | Chien-Ming Wang | Jeremy Accardo | 505 | 422 | 83 |
| 2007-07-20 | vs TBA | 95 | L 4-14 | 47-46 | 2 | 53,957 | Mike Mussina | Edwin Jackson | Edwin Jackson | Mike Mussina | | 509 | 436 | 73 |
| 2007-07-21 | vs TBA | 96 | W 7-3 | 48-46 | 2 | 54,412 | Kei Igawa | Jason Hammel | Luis Vizcaino | Jae Kuk Ryu | | 516 | 439 | 77 |
| 2007-07-21 | vs TBA | 97 | W 17-5 | 48-46 | 2 | 52,983 | Matt DeSalvo | J.P. Howell | Luis Vizcaino | J.P. Howell | | 533 | 444 | 89 |
| 2007-07-22 | vs TBA | 98 | W 21-4 | 49-46 | 2 | 54,751 | Andy Pettitte | James Shields | Andy Pettitte | James Shields | | 554 | 448 | 106 |
| 2007-07-23 | @ KCA | 99 | W 9-2 | 50-46 | 2 | 30,476 | Roger Clemens | Odalis Perez | Roger Clemens | Odalis Perez | | 563 | 450 | 113 |
| 2007-07-24 | @ KCA | 100 | W 9-4 | 51-46 | 2 | 38,212 | Chien-Ming Wang | Scott Elarton | Chien-Ming Wang | Scott Elarton | | 572 | 454 | 118 |
| 2007-07-25 | @ KCA | 101 | W 7-1 | 52-46 | 2 | 28,460 | Mike Mussina | Gil Meche | Mike Mussina | Gil Meche | | 579 | 455 | 124 |
| 2007-07-26 | @ KCA | 102 | L 0-7 | 52-47 | 2 | 37,036 | Kei Igawa | Jorge de la Rosa | Jorge de la Rosa | Kei Igawa | | 579 | 462 | 117 |
| 2007-07-27 | @ BAL | 103 | L 2-4 | 52-48 | 2 | 47,952 | Andy Pettitte | Jeremy Guthrie | Jeremy Guthrie | Andy Pettitte | Chad Bradford | 581 | 466 | 115 |
| 2007-07-28 | @ BAL | 104 | L 5-7 | 52-49 | 2 | 48,402 | Roger Clemens | Brian Burres | Brian Burres | Roger Clemens | Jamie Walker | 586 | 473 | 113 |
| 2007-07-29 | @ BAL | 105 | W 10-6 | 53-49 | 2 | 47,936 | Chien-Ming Wang | Daniel Cabrera | Chien-Ming Wang | Daniel Cabrera | | 596 | 479 | 117 |
| 2007-07-31 | vs CHA | 106 | W 16-3 | 54-49 | 2 | 53,958 | Mike Mussina | Jose Contreras | Mike Mussina | Jose Contreras | | 612 | 482 | 130 |
| 2007-08-01 | vs CHA | 107 | W 8-1 | 55-49 | 2 | 53,342 | Andy Pettitte | John Danks | Andy Pettitte | John Danks | | 620 | 483 | 137 |
| 2007-08-02 | vs CHA | 108 | L 9-13 | 55-50 | 2 | 54,869 | Roger Clemens | Jon Garland | Boone Logan | Jeff Karstens | | 629 | 496 | 133 |
| 2007-08-03 | vs KCA | 109 | W 7-1 | 56-50 | 2 | 54,246 | Chien-Ming Wang | Odalis Perez | Chien-Ming Wang | Odalis Perez | | 636 | 497 | 139 |
| 2007-08-04 | vs KCA | 110 | W 16-8 | 57-50 | 2 | 54,056 | Phil Hughes | Kyle Davies | Mike Myers | John Bale | | 652 | 505 | 147 |
| 2007-08-05 | vs KCA | 111 | W 8-5 | 58-50 | 2 | 54,525 | Mike Mussina | Gil Meche | Mike Mussina | Gil Meche | Mariano Rivera | 660 | 510 | 150 |
| 2007-08-06 | @ TOR | 112 | W 5-4 | 59-50 | 2 | 42,714 | Andy Pettitte | Jesse Litsch | Andy Pettitte | Scott Downs | Mariano Rivera | 665 | 514 | 151 |
| 2007-08-07 | @ TOR | 113 | W 9-2 | 60-50 | 2 | 38,078 | Roger Clemens | Josh Towers | Roger Clemens | Josh Towers | | 674 | 516 | 158 |
| 2007-08-08 | @ TOR | 114 | L 4-15 | 60-51 | 2 | 40,811 | Chien-Ming Wang | Roy Halladay | Roy Halladay | Chien-Ming Wang | | 678 | 531 | 147 |
| 2007-08-10 | @ CLE | 115 | W 6-1 | 61-51 | 2 | 41,675 | Phil Hughes | Fausto Carmona | Phil Hughes | Fausto Carmona | | 684 | 532 | 152 |
| 2007-08-11 | @ CLE | 116 | W 11-2 | 62-51 | 2 | 41,977 | Mike Mussina | Paul Byrd | Mike Mussina | Paul Byrd | | 695 | 534 | 161 |
| 2007-08-12 | @ CLE | 117 | W 5-3 | 63-51 | 2 | 41,612 | Andy Pettitte | Jake Westbrook | Andy Pettitte | Jake Westbrook | Mariano Rivera | 700 | 537 | 163 |
| 2007-08-13 | vs BAL | 118 | W 7-6 | 64-51 | 2 | 54,398 | Chien-Ming Wang | Jeremy Guthrie | Mariano Rivera | Chad Bradford | | 707 | 543 | 164 |
| 2007-08-14 | vs BAL | 119 | L 0-12 | 64-52 | 2 | 52,567 | Jeff Karstens | Daniel Cabrera | Daniel Cabrera | Jeff Karstens | | 707 | 555 | 152 |
| 2007-08-15 | vs BAL | 120 | L 3-6 | 64-53 | 2 | 53,363 | Phil Hughes | Erik Bedard | Chad Bradford | Mariano Rivera | | 710 | 561 | 149 |
| 2007-08-16 | vs DET | 121 | L 5-8 | 64-54 | 2 | 53,914 | Mike Mussina | Justin Verlander | Justin Verlander | Mike Mussina | | 715 | 569 | 146 |
| 2007-08-17 | vs DET | 122 | W 6-1 | 65-54 | 2 | 54,290 | Andy Pettitte | Nate Robertson | Andy Pettitte | Nate Robertson | | 721 | 570 | 151 |
| 2007-08-18 | vs DET | 123 | W 5-2 | 66-54 | 2 | 54,802 | Roger Clemens | Chad Durbin | Roger Clemens | Chad Durbin | Mariano Rivera | 726 | 572 | 154 |
| 2007-08-19 | vs DET | 124 | W 9-3 | 67-54 | 2 | 55,071 | Chien-Ming Wang | Jeremy Bonderman | Chien-Ming Wang | Jeremy Bonderman | Edwar Ramirez | 735 | 575 | 160 |
| 2007-08-20 | @ ANA | 125 | L 6-7 | 67-55 | 2 | 44,249 | Phil Hughes | Dustin Moseley | Darren Oliver | Sean Henn | | 741 | 582 | 159 |
| 2007-08-21 | @ ANA | 126 | L 9-18 | 67-56 | 2 | 44,264 | Mike Mussina | Kelvim Escobar | Kelvim Escobar | Mike Mussina | Marcus Gwyn | 750 | 600 | 150 |
| 2007-08-22 | @ ANA | 127 | W 8-2 | 68-56 | 2 | 44,326 | Andy Pettitte | John Lackey | Andy Pettitte | John Lackey | | 758 | 602 | 156 |
| 2007-08-24 | @ DET | 128 | L 6-9 | 68-57 | 2 | 44,163 | Roger Clemens | Andrew Miller | Chad Durbin | Sean Henn | | 764 | 611 | 153 |
| 2007-08-25 | @ DET | 129 | W 7-2 | 69-57 | 2 | 44,250 | Chien-Ming Wang | Jeremy Bonderman | Chien-Ming Wang | Jeremy Bonderman | | 771 | 613 | 158 |
| 2007-08-26 | @ DET | 130 | L 4-5 | 69-58 | 2 | 43,268 | Phil Hughes | Jair Jurrjens | Bobby Seay | Phil Hughes | Todd Jones | 775 | 618 | 157 |
| 2007-08-27 | @ DET | 131 | L 0-16 | 69-59 | 2 | 42,428 | Mike Mussina | Justin Verlander | Justin Verlander | Mike Mussina | | 775 | 634 | 141 |
| 2007-08-28 | vs BOS | 132 | W 5-3 | 70-59 | 2 | 55,037 | Andy Pettitte | Daisuke Matsuzaka | Andy Pettitte | Daisuke Matsuzaka | Mariano Rivera | 780 | 637 | 143 |
| 2007-08-29 | vs BOS | 133 | W 4-3 | 71-59 | 2 | 54,986 | Roger Clemens | Josh Beckett | Roger Clemens | Josh Beckett | Mariano Rivera | 784 | 640 | 144 |
| 2007-08-30 | vs BOS | 134 | W 5-0 | 72-59 | 2 | 55,067 | Chien-Ming Wang | Curt Schilling | Chien-Ming Wang | Curt Schilling | | 789 | 640 | 149 |
| 2007-08-31 | vs TBA | 135 | L 1-9 | 72-60 | 2 | 53,275 | Phil Hughes | Andy Sonnanstine | Andy Sonnanstine | Phil Hughes | | 790 | 649 | 141 |
| 2007-09-01 | vs TBA | 136 | W 9-6 | 73-60 | 2 | 53,637 | Ian Kennedy | Edwin Jackson | Ian Kennedy | Edwin Jackson | Mariano Rivera | 799 | 655 | 144 |
| 2007-09-02 | vs TBA | 137 | L 2-8 | 73-61 | 2 | 53,957 | Andy Pettitte | Jason Hammel | Jason Hammel | Andy Pettitte | | 801 | 663 | 138 |
| 2007-09-03 | vs SEA | 138 | L 1-7 | 73-62 | 2 | 54,522 | Roger Clemens | Felix Hernandez | Felix Hernandez | Roger Clemens | | 802 | 670 | 132 |
| 2007-09-04 | vs SEA | 139 | W 12-3 | 74-62 | 2 | 52,487 | Chien-Ming Wang | Horacio Ramirez | Chien-Ming Wang | Horacio Ramirez | | 814 | 673 | 141 |
| 2007-09-05 | vs SEA | 140 | W 10-2 | 75-62 | 2 | 52,538 | Phil Hughes | Jarrod Washburn | Joba Chamberlain | Jarrod Washburn | | 824 | 675 | 149 |
| 2007-09-07 | @ KCA | 141 | W 3-2 | 76-62 | 2 | 27,462 | Ian Kennedy | Gil Meche | Kyle Farnsworth | Neal Musser | Mariano Rivera | 827 | 677 | 150 |
| 2007-09-08 | @ KCA | 142 | W 11-5 | 77-62 | 2 | 35,518 | Andy Pettitte | Brian Bannister | Andy Pettitte | Brian Bannister | | 838 | 682 | 156 |
| 2007-09-09 | @ KCA | 143 | W 6-3 | 78-62 | 2 | 24,910 | Chien-Ming Wang | Zack Greinke | Chien-Ming Wang | Brandon Duckworth | Mariano Rivera | 844 | 685 | 159 |
| 2007-09-11 | @ TOR | 144 | W 9-2 | 79-62 | 2 | 30,472 | Phil Hughes | Shaun Marcum | Phil Hughes | Shaun Marcum | | 853 | 687 | 166 |
| 2007-09-12 | @ TOR | 145 | W 4-1 | 80-62 | 2 | 27,082 | Mike Mussina | Dustin McGowan | Mike Mussina | Dustin McGowan | Mariano Rivera | 857 | 688 | 169 |
| 2007-09-13 | @ TOR | 146 | L 1-2 | 80-63 | 2 | 32,632 | Ian Kennedy | A.J. Burnett | Scott Downs | Chris Britton | | 858 | 690 | 168 |
| 2007-09-14 | @ BOS | 147 | W 8-7 | 81-63 | 2 | 36,590 | Andy Pettitte | Daisuke Matsuzaka | Brian Bruney | Jonathan Papelbon | Mariano Rivera | 866 | 697 | 169 |
| 2007-09-15 | @ BOS | 148 | L 1-10 | 81-64 | 2 | 36,215 | Chien-Ming Wang | Josh Beckett | Josh Beckett | Chien-Ming Wang | | 867 | 707 | 160 |
| 2007-09-16 | @ BOS | 149 | W 4-3 | 82-64 | 2 | 36,533 | Roger Clemens | Curt Schilling | Joba Chamberlain | Curt Schilling | Mariano Rivera | 871 | 710 | 161 |
| 2007-09-17 | vs BAL | 150 | W 8-5 | 83-64 | 2 | 52,548 | Phil Hughes | Daniel Cabrera | Phil Hughes | Daniel Cabrera | Mariano Rivera | 879 | 715 | 164 |
| 2007-09-18 | vs BAL | 151 | W 12-0 | 84-64 | 2 | 52,685 | Mike Mussina | Jon Leicester | Mike Mussina | Jon Leicester | | 891 | 715 | 176 |
| 2007-09-19 | vs BAL | 152 | W 2-1 | 85-64 | 2 | 53,857 | Andy Pettitte | Brian Burres | Andy Pettitte | Brian Burres | Mariano Rivera | 893 | 716 | 177 |
| 2007-09-21 | vs TOR | 153 | L 4-5 | 85-65 | 2 | 54,151 | Chien-Ming Wang | Roy Halladay | Joe Kennedy | Brian Bruney | Jason Frasor | 897 | 721 | 176 |
| 2007-09-22 | vs TOR | 154 | W 12-11 | 86-65 | 2 | 54,887 | Phil Hughes | Shaun Marcum | Jeff Karstens | Josh Towers | | 909 | 732 | 177 |
| 2007-09-23 | vs TOR | 155 | W 7-5 | 87-65 | 2 | 54,983 | Mike Mussina | Dustin McGowan | Mike Mussina | Dustin McGowan | Joba Chamberlain | 916 | 737 | 179 |
| 2007-09-24 | vs TOR | 156 | L 1-4 | 87-66 | 2 | 53,281 | Andy Pettitte | Jesse Litsch | Jesse Litsch | Andy Pettitte | Casey Janssen | 917 | 741 | 176 |
| 2007-09-25 | @ TBA | 157 | L 6-7 | 87-67 | 2 | 24,503 | Kei Igawa | Jason Hammel | Gary Glover | Jeff Karstens | | 923 | 748 | 175 |
| 2007-09-26 | @ TBA | 158 | W 12-4 | 88-67 | 2 | 21,621 | Chien-Ming Wang | J.P. Howell | Chien-Ming Wang | J.P. Howell | | 935 | 752 | 183 |
| 2007-09-27 | @ TBA | 159 | W 3-1 | 89-67 | 2 | 28,962 | Phil Hughes | Scott Kazmir | Phil Hughes | Jon Switzer | Jose Veras | 938 | 753 | 185 |
| 2007-09-28 | @ BAL | 160 | L 9-10 | 89-68 | 2 | 38,113 | Mike Mussina | Jon Leicester | Chad Bradford | Edwar Ramirez | | 947 | 763 | 184 |
| 2007-09-29 | @ BAL | 161 | W 11-10 | 90-68 | 2 | 47,616 | Andy Pettitte | Daniel Cabrera | Andy Pettitte | Daniel Cabrera | Jose Veras | 958 | 773 | 185 |
| 2007-09-30 | @ BAL | 162 | W 10-4 | 91-68 | 2 | 43,589 | Sean Henn | Brian Burres | Chase Wright | Brian Burres | | 968 | 777 | 191 |