| 2007-04-02 | @ COL | 1 | W 8-6 | 1-0 | 1 | 48,169 | Brandon Webb | Aaron Cook | Juan Cruz | LaTroy Hawkins | Jose Valverde | 8 | 6 | 2 |
| 2007-04-03 | @ COL | 2 | L 3-4 | 1-1 | 2 | 20,547 | Livan Hernandez | Jeff Francis | Byung-Hyun Kim | Jose Valverde | | 11 | 10 | 1 |
| 2007-04-04 | @ COL | 3 | L 4-11 | 1-2 | 3 | 19,352 | Doug Davis | Rodrigo Lopez | Rodrigo Lopez | Doug Davis | | 15 | 21 | -6 |
| 2007-04-05 | @ WAS | 4 | W 4-3 | 2-2 | 3 | 16,017 | Edgar Gonzalez | Jason Bergmann | Edgar Gonzalez | Jason Bergmann | Jose Valverde | 19 | 24 | -5 |
| 2007-04-06 | @ WAS | 5 | W 7-1 | 3-2 | 2 | 19,234 | Micah Owings | Jerome Williams | Micah Owings | Jerome Williams | | 26 | 25 | 1 |
| 2007-04-07 | @ WAS | 6 | W 7-1 | 4-2 | 1 | 16,617 | Brandon Webb | John Patterson | Brandon Webb | John Patterson | | 33 | 26 | 7 |
| 2007-04-08 | @ WAS | 7 | W 3-1 | 5-2 | 1 | 17,224 | Livan Hernandez | Shawn Hill | Livan Hernandez | Shawn Hill | Jose Valverde | 36 | 27 | 9 |
| 2007-04-09 | vs CIN | 8 | W 3-2 | 6-2 | 1 | 41,803 | Doug Davis | Bronson Arroyo | Brandon Lyon | Kirk Saarloos | Jose Valverde | 39 | 29 | 10 |
| 2007-04-10 | vs CIN | 9 | W 5-4 | 7-2 | 1 | 21,225 | Edgar Gonzalez | Kyle Lohse | Juan Cruz | David Weathers | | 44 | 33 | 11 |
| 2007-04-11 | vs CIN | 10 | L 2-3 | 7-3 | 1 | 19,534 | Micah Owings | Matt Belisle | Matt Belisle | Micah Owings | David Weathers | 46 | 36 | 10 |
| 2007-04-13 | vs COL | 11 | L 3-6 | 7-4 | 2 | 20,219 | Brandon Webb | Josh Fogg | Jeremy Affeldt | Brandon Webb | Brian Fuentes | 49 | 42 | 7 |
| 2007-04-14 | vs COL | 12 | W 5-4 | 8-4 | 1 | 27,721 | Livan Hernandez | Aaron Cook | Brandon Lyon | LaTroy Hawkins | Jose Valverde | 54 | 46 | 8 |
| 2007-04-15 | vs COL | 13 | W 6-4 | 9-4 | 1 | 21,904 | Doug Davis | Byung-Hyun Kim | Doug Davis | Byung-Hyun Kim | Jose Valverde | 60 | 50 | 10 |
| 2007-04-16 | vs LAN | 14 | L 1-5 | 9-5 | 2 | 27,427 | Edgar Gonzalez | Brad Penny | Brad Penny | Edgar Gonzalez | | 61 | 55 | 6 |
| 2007-04-17 | vs LAN | 15 | L 4-6 | 9-6 | 2 | 25,735 | Micah Owings | Brett Tomko | Chad Billingsley | Tony Pena | Takashi Saito | 65 | 61 | 4 |
| 2007-04-18 | @ SDN | 16 | W 5-2 | 10-6 | 2 | 26,872 | Brandon Webb | David Wells | Tony Pena | Mike Thompson | Jose Valverde | 70 | 63 | 7 |
| 2007-04-19 | @ SDN | 17 | L 6-11 | 10-7 | 2 | 32,224 | Livan Hernandez | Jake Peavy | Jake Peavy | Livan Hernandez | | 76 | 74 | 2 |
| 2007-04-20 | @ SFN | 18 | L 2-4 | 10-8 | 3 | 39,010 | Doug Davis | Russ Ortiz | Russ Ortiz | Doug Davis | Armando Benitez | 78 | 78 | 0 |
| 2007-04-21 | @ SFN | 19 | L 0-1 | 10-9 | 3 | 36,281 | Edgar Gonzalez | Barry Zito | Barry Zito | Edgar Gonzalez | Armando Benitez | 78 | 79 | -1 |
| 2007-04-22 | @ SFN | 20 | L 1-2 | 10-10 | 4 | 36,868 | Yusmeiro Petit | Matt Cain | Matt Cain | Yusmeiro Petit | | 79 | 81 | -2 |
| 2007-04-24 | vs SDN | 21 | L 5-10 | 10-11 | 4 | 19,508 | Randy Johnson | David Wells | David Wells | Randy Johnson | Trevor Hoffman | 84 | 91 | -7 |
| 2007-04-25 | vs SDN | 22 | W 3-2 | 11-11 | 4 | 18,307 | Brandon Webb | Jake Peavy | Tony Pena | Trevor Hoffman | | 87 | 93 | -6 |
| 2007-04-26 | vs SDN | 23 | W 7-4 | 12-11 | 4 | 16,792 | Livan Hernandez | Chris Young | Livan Hernandez | Chris Young | Jose Valverde | 94 | 97 | -3 |
| 2007-04-27 | vs SFN | 24 | W 3-2 | 13-11 | 3 | 24,798 | Doug Davis | Barry Zito | Doug Davis | Barry Zito | Jose Valverde | 97 | 99 | -2 |
| 2007-04-28 | vs SFN | 25 | W 5-4 | 14-11 | 2 | 32,147 | Edgar Gonzalez | Matt Cain | Dustin Nippert | Vinnie Chulk | Jose Valverde | 102 | 103 | -1 |
| 2007-04-29 | vs SFN | 26 | W 5-4 | 15-11 | 2 | 28,818 | Randy Johnson | Matt Morris | Brandon Medders | Matt Morris | Brandon Lyon | 107 | 107 | 0 |
| 2007-04-30 | @ LAN | 27 | W 9-1 | 16-11 | 1 | 53,126 | Brandon Webb | Randy Wolf | Brandon Webb | Randy Wolf | | 116 | 108 | 8 |
| 2007-05-01 | @ LAN | 28 | L 1-2 | 16-12 | 2 | 36,029 | Livan Hernandez | Brad Penny | Takashi Saito | Brandon Lyon | | 117 | 110 | 7 |
| 2007-05-02 | @ LAN | 29 | L 1-2 | 16-13 | 2 | 34,825 | Doug Davis | Mark Hendrickson | Mark Hendrickson | Doug Davis | Takashi Saito | 118 | 112 | 6 |
| 2007-05-03 | vs NYN | 30 | L 4-9 | 16-14 | 3 | 19,710 | Micah Owings | Tom Glavine | Aaron Heilman | Jose Valverde | | 122 | 121 | 1 |
| 2007-05-04 | vs NYN | 31 | L 3-5 | 16-15 | 4 | 26,268 | Randy Johnson | John Maine | John Maine | Randy Johnson | Billy Wagner | 125 | 126 | -1 |
| 2007-05-05 | vs NYN | 32 | L 2-6 | 16-16 | 4 | 30,339 | Brandon Webb | Jorge Sosa | Jorge Sosa | Brandon Webb | | 127 | 132 | -5 |
| 2007-05-06 | vs NYN | 33 | W 3-1 | 17-16 | 4 | 35,363 | Livan Hernandez | Mike Pelfrey | Livan Hernandez | Mike Pelfrey | Jose Valverde | 130 | 133 | -3 |
| 2007-05-07 | vs PHI | 34 | W 4-3 | 18-16 | 4 | 19,592 | Doug Davis | Freddy Garcia | Brandon Lyon | Francisco Rosario | Jose Valverde | 134 | 136 | -2 |
| 2007-05-08 | vs PHI | 35 | W 3-2 | 19-16 | 3 | 22,888 | Micah Owings | Adam Eaton | Micah Owings | Adam Eaton | Tony Pena | 137 | 138 | -1 |
| 2007-05-09 | vs PHI | 36 | L 3-9 | 19-17 | 3 | 25,286 | Randy Johnson | Jamie Moyer | Jamie Moyer | Brandon Medders | Brett Myers | 140 | 147 | -7 |
| 2007-05-11 | @ HOU | 37 | W 3-1 | 20-17 | 2 | 36,080 | Brandon Webb | Chris Sampson | Brandon Webb | Chris Sampson | | 143 | 148 | -5 |
| 2007-05-12 | @ HOU | 38 | L 4-10 | 20-18 | 2 | 36,142 | Livan Hernandez | Roy Oswalt | Roy Oswalt | Livan Hernandez | | 147 | 158 | -11 |
| 2007-05-13 | @ HOU | 39 | L 2-5 | 20-19 | 4 | 37,230 | Doug Davis | Wandy Rodriguez | Wandy Rodriguez | Doug Davis | | 149 | 163 | -14 |
| 2007-05-15 | @ COL | 40 | W 3-0 | 21-19 | 2 | 20,178 | Randy Johnson | Jason Hirsh | Randy Johnson | Jason Hirsh | Jose Valverde | 152 | 163 | -11 |
| 2007-05-16 | @ COL | 41 | L 3-5 | 21-20 | 3 | 20,023 | Brandon Webb | Aaron Cook | Aaron Cook | Brandon Webb | Brian Fuentes | 155 | 168 | -13 |
| 2007-05-17 | @ COL | 42 | W 3-1 | 22-20 | 3 | 23,610 | Livan Hernandez | Josh Fogg | Livan Hernandez | Josh Fogg | Jose Valverde | 158 | 169 | -11 |
| 2007-05-18 | @ PIT | 43 | L 5-11 | 22-21 | 3 | 32,682 | Doug Davis | Ian Snell | Ian Snell | Doug Davis | | 163 | 180 | -17 |
| 2007-05-19 | @ PIT | 44 | W 9-8 | 23-21 | 3 | 30,677 | Micah Owings | Tom Gorzelanny | Doug Slaten | Matt Capps | Jose Valverde | 172 | 188 | -16 |
| 2007-05-20 | @ PIT | 45 | W 5-2 | 24-21 | 3 | 24,282 | Randy Johnson | Paul Maholm | Randy Johnson | Paul Maholm | Jose Valverde | 177 | 190 | -13 |
| 2007-05-21 | vs COL | 46 | W 6-5 | 25-21 | 3 | 19,782 | Brandon Webb | Aaron Cook | Doug Slaten | Jeremy Affeldt | Jose Valverde | 183 | 195 | -12 |
| 2007-05-22 | vs COL | 47 | L 1-3 | 25-22 | 3 | 23,058 | Livan Hernandez | Josh Fogg | Manuel Corpas | Brandon Lyon | Brian Fuentes | 184 | 198 | -14 |
| 2007-05-23 | vs COL | 48 | L 0-2 | 25-23 | 4 | 18,373 | Doug Davis | Jeff Francis | Jeff Francis | Doug Davis | Brian Fuentes | 184 | 200 | -16 |
| 2007-05-24 | vs HOU | 49 | W 9-1 | 26-23 | 3 | 18,130 | Micah Owings | Wandy Rodriguez | Micah Owings | Wandy Rodriguez | | 193 | 201 | -8 |
| 2007-05-25 | vs HOU | 50 | W 13-3 | 27-23 | 3 | 23,298 | Edgar Gonzalez | Woody Williams | Edgar Gonzalez | Woody Williams | | 206 | 204 | 2 |
| 2007-05-26 | vs HOU | 51 | W 5-4 | 28-23 | 3 | 27,836 | Brandon Webb | Chris Sampson | Brandon Webb | Chris Sampson | Jose Valverde | 211 | 208 | 3 |
| 2007-05-27 | vs HOU | 52 | W 8-4 | 29-23 | 3 | 26,621 | Livan Hernandez | Roy Oswalt | Livan Hernandez | Roy Oswalt | | 219 | 212 | 7 |
| 2007-05-28 | @ PHI | 53 | W 5-4 | 30-23 | 3 | 41,985 | Doug Davis | Freddy Garcia | Doug Davis | Freddy Garcia | Brandon Lyon | 224 | 216 | 8 |
| 2007-05-29 | @ PHI | 54 | W 11-5 | 31-23 | 2 | 27,643 | Micah Owings | Jon Lieber | Micah Owings | Jon Lieber | | 235 | 221 | 14 |
| 2007-05-30 | @ PHI | 55 | W 4-3 | 32-23 | 2 | 33,281 | Randy Johnson | Jamie Moyer | Randy Johnson | Jamie Moyer | Jose Valverde | 239 | 224 | 15 |
| 2007-06-01 | @ NYN | 56 | W 5-1 | 33-23 | 2 | 40,230 | Brandon Webb | John Maine | Brandon Webb | John Maine | | 244 | 225 | 19 |
| 2007-06-02 | @ NYN | 57 | L 1-7 | 33-24 | 3 | 45,219 | Livan Hernandez | Jorge Sosa | Jorge Sosa | Livan Hernandez | | 245 | 232 | 13 |
| 2007-06-03 | @ NYN | 58 | W 4-1 | 34-24 | 3 | 53,012 | Doug Davis | Oliver Perez | Doug Davis | Oliver Perez | Jose Valverde | 249 | 233 | 16 |
| 2007-06-05 | vs SFN | 59 | W 4-3 | 35-24 | 2 | 25,848 | Randy Johnson | Matt Cain | Brandon Lyon | Kevin Correia | | 253 | 236 | 17 |
| 2007-06-06 | vs SFN | 60 | W 1-0 | 36-24 | 2 | 24,398 | Brandon Webb | Matt Morris | Brandon Webb | Matt Morris | Jose Valverde | 254 | 236 | 18 |
| 2007-06-07 | vs SFN | 61 | L 4-5 | 36-25 | 2 | 21,984 | Livan Hernandez | Noah Lowry | Jack Taschner | Brandon Medders | Steve Kline | 258 | 241 | 17 |
| 2007-06-08 | vs BOS | 62 | L 3-10 | 36-26 | 2 | 40,435 | Doug Davis | Josh Beckett | Josh Beckett | Doug Davis | | 261 | 251 | 10 |
| 2007-06-09 | vs BOS | 63 | L 3-4 | 36-27 | 2 | 49,826 | Micah Owings | Julian Tavarez | Hideki Okajima | Juan Cruz | Jonathan Papelbon | 264 | 255 | 9 |
| 2007-06-10 | vs BOS | 64 | W 5-1 | 37-27 | 2 | 46,622 | Randy Johnson | Daisuke Matsuzaka | Randy Johnson | Daisuke Matsuzaka | | 269 | 256 | 13 |
| 2007-06-12 | @ NYA | 65 | L 1-4 | 37-28 | 2 | 51,577 | Brandon Webb | Chien-Ming Wang | Chien-Ming Wang | Brandon Webb | Mariano Rivera | 270 | 260 | 10 |
| 2007-06-13 | @ NYA | 66 | L 2-7 | 37-29 | 3 | 53,891 | Livan Hernandez | Mike Mussina | Mike Mussina | Livan Hernandez | | 272 | 267 | 5 |
| 2007-06-14 | @ NYA | 67 | L 1-7 | 37-30 | 3 | 53,712 | Doug Davis | Andy Pettitte | Andy Pettitte | Doug Davis | | 273 | 274 | -1 |
| 2007-06-15 | @ BAL | 68 | W 7-3 | 38-30 | 3 | 26,174 | Micah Owings | Erik Bedard | Doug Slaten | Todd Williams | | 280 | 277 | 3 |
| 2007-06-16 | @ BAL | 69 | W 8-4 | 39-30 | 3 | 26,964 | Edgar Gonzalez | Daniel Cabrera | Edgar Gonzalez | Daniel Cabrera | | 288 | 281 | 7 |
| 2007-06-17 | @ BAL | 70 | W 6-4 | 40-30 | 2 | 27,934 | Brandon Webb | Brian Burres | Brandon Webb | Chad Bradford | Jose Valverde | 294 | 285 | 9 |
| 2007-06-18 | vs TBA | 71 | L 2-10 | 40-31 | 3 | 18,963 | Livan Hernandez | Edwin Jackson | Jason Hammel | Livan Hernandez | | 296 | 295 | 1 |
| 2007-06-19 | vs TBA | 72 | W 10-8 | 41-31 | 3 | 19,761 | Doug Davis | J.P. Howell | Brandon Lyon | Alberto Reyes | | 306 | 303 | 3 |
| 2007-06-20 | vs TBA | 73 | W 7-4 | 42-31 | 2 | 31,805 | Micah Owings | James Shields | Micah Owings | James Shields | Jose Valverde | 313 | 307 | 6 |
| 2007-06-22 | vs BAL | 74 | L 1-7 | 42-32 | 3 | 21,722 | Brandon Webb | Daniel Cabrera | Daniel Cabrera | Brandon Webb | | 314 | 314 | 0 |
| 2007-06-23 | vs BAL | 75 | W 7-4 | 43-32 | 2 | 29,832 | Livan Hernandez | Brian Burres | Juan Cruz | Rob Bell | Jose Valverde | 321 | 318 | 3 |
| 2007-06-24 | vs BAL | 76 | W 8-3 | 44-32 | 1 | 27,744 | Doug Davis | Steve Trachsel | Doug Davis | Steve Trachsel | | 329 | 321 | 8 |
| 2007-06-25 | vs LAN | 77 | L 1-8 | 44-33 | 1 | 24,966 | Micah Owings | Brad Penny | Brad Penny | Micah Owings | | 330 | 329 | 1 |
| 2007-06-26 | vs LAN | 78 | L 5-6 | 44-34 | 3 | 28,734 | Edgar Gonzalez | Chad Billingsley | Jonathan Broxton | Doug Slaten | Takashi Saito | 335 | 335 | 0 |
| 2007-06-27 | vs LAN | 79 | W 2-0 | 45-34 | 2 | 26,867 | Brandon Webb | Derek Lowe | Brandon Webb | Derek Lowe | Jose Valverde | 337 | 335 | 2 |
| 2007-06-28 | vs LAN | 80 | L 5-9 | 45-35 | 3 | 26,526 | Randy Johnson | Randy Wolf | Randy Wolf | Randy Johnson | Takashi Saito | 342 | 344 | -2 |
| 2007-06-29 | @ SFN | 81 | W 4-3 | 46-35 | 2 | 39,146 | Livan Hernandez | Matt Morris | Tony Pena | Brad Hennessey | Jose Valverde | 346 | 347 | -1 |
| 2007-06-30 | @ SFN | 82 | L 1-4 | 46-36 | 2 | 43,515 | Doug Davis | Noah Lowry | Noah Lowry | Doug Davis | Brad Hennessey | 347 | 351 | -4 |
| 2007-07-01 | @ SFN | 83 | L 0-13 | 46-37 | 3 | 42,154 | Micah Owings | Tim Lincecum | Tim Lincecum | Micah Owings | | 347 | 364 | -17 |
| 2007-07-02 | @ SLN | 84 | L 3-11 | 46-38 | 3 | 42,312 | Brandon Webb | Braden Looper | Russ Springer | Brandon Webb | | 350 | 375 | -25 |
| 2007-07-03 | @ SLN | 85 | W 7-1 | 47-38 | 3 | 42,127 | Yusmeiro Petit | Todd Wellemeyer | Yusmeiro Petit | Todd Wellemeyer | | 357 | 376 | -19 |
| 2007-07-04 | @ SLN | 86 | L 4-5 | 47-39 | 3 | 43,538 | Livan Hernandez | Brad Thompson | Ryan Franklin | Brandon Lyon | Jason Isringhausen | 361 | 381 | -20 |
| 2007-07-05 | @ SLN | 87 | L 2-3 | 47-40 | 3 | 42,184 | Doug Davis | Adam Wainwright | Adam Wainwright | Doug Davis | Jason Isringhausen | 363 | 384 | -21 |
| 2007-07-06 | @ CIN | 88 | L 1-8 | 47-41 | 3 | 20,445 | Micah Owings | Kyle Lohse | Kyle Lohse | Micah Owings | | 364 | 392 | -28 |
| 2007-07-07 | @ CIN | 89 | L 4-5 | 47-42 | 3 | 34,410 | Brandon Webb | Homer Bailey | Jon Coutlangus | Tony Pena | David Weathers | 368 | 397 | -29 |
| 2007-07-08 | @ CIN | 90 | L 3-4 | 47-43 | 3 | 28,169 | Yusmeiro Petit | Aaron Harang | Kirk Saarloos | Jose Valverde | | 371 | 401 | -30 |
| 2007-07-13 | vs SDN | 91 | W 8-3 | 48-43 | 3 | 30,981 | Doug Davis | Greg Maddux | Doug Davis | Greg Maddux | | 379 | 404 | -25 |
| 2007-07-14 | vs SDN | 92 | W 5-4 | 49-43 | 3 | 36,833 | Livan Hernandez | Chris Young | Brandon Lyon | Scott Linebrink | Jose Valverde | 384 | 408 | -24 |
| 2007-07-15 | vs SDN | 93 | L 0-4 | 49-44 | 3 | 30,343 | Brandon Webb | Justin Germano | Justin Germano | Brandon Webb | | 384 | 412 | -28 |
| 2007-07-16 | @ MIL | 94 | L 3-4 | 49-45 | 3 | 36,381 | Micah Owings | David Bush | David Bush | Micah Owings | Francisco Cordero | 387 | 416 | -29 |
| 2007-07-17 | @ MIL | 95 | L 2-3 | 49-46 | 3 | 32,540 | Yusmeiro Petit | Claudio Vargas | Claudio Vargas | Yusmeiro Petit | Francisco Cordero | 389 | 419 | -30 |
| 2007-07-18 | @ MIL | 96 | W 5-2 | 50-46 | 3 | 30,247 | Doug Davis | Chris Capuano | Tony Pena | Grant Balfour | Jose Valverde | 394 | 421 | -27 |
| 2007-07-19 | @ MIL | 97 | L 1-10 | 50-47 | 3 | 41,156 | Livan Hernandez | Yovani Gallardo | Yovani Gallardo | Livan Hernandez | Matt Wise | 395 | 431 | -36 |
| 2007-07-20 | @ CHN | 98 | L 2-6 | 50-48 | 4 | 41,071 | Brandon Webb | Jason Marquis | Jason Marquis | Brandon Webb | | 397 | 437 | -40 |
| 2007-07-21 | @ CHN | 99 | W 3-2 | 51-48 | 3 | 41,632 | Micah Owings | Rich Hill | Juan Cruz | Bob Howry | Jose Valverde | 400 | 439 | -39 |
| 2007-07-22 | @ CHN | 100 | W 3-0 | 52-48 | 3 | 41,705 | Yusmeiro Petit | Sean Marshall | Yusmeiro Petit | Sean Marshall | Jose Valverde | 403 | 439 | -36 |
| 2007-07-23 | vs FLO | 101 | W 4-3 | 53-48 | 3 | 19,620 | Doug Davis | Dontrelle Willis | Doug Davis | Dontrelle Willis | Jose Valverde | 407 | 442 | -35 |
| 2007-07-24 | vs FLO | 102 | W 9-3 | 54-48 | 3 | 21,035 | Livan Hernandez | Sergio Mitre | Livan Hernandez | Sergio Mitre | | 416 | 445 | -29 |
| 2007-07-25 | vs FLO | 103 | W 7-0 | 55-48 | 3 | 20,154 | Brandon Webb | Scott Olsen | Brandon Webb | Scott Olsen | | 423 | 445 | -22 |
| 2007-07-26 | vs FLO | 104 | W 7-4 | 56-48 | 2 | 18,721 | Micah Owings | Byung-Hyun Kim | Tony Pena | Armando Benitez | | 430 | 449 | -19 |
| 2007-07-27 | vs ATL | 105 | W 8-7 | 57-48 | 2 | 27,151 | Yusmeiro Petit | Jo-Jo Reyes | Edgar Gonzalez | Wil Ledezma | | 438 | 456 | -18 |
| 2007-07-28 | vs ATL | 106 | W 4-3 | 58-48 | 2 | 33,664 | Doug Davis | John Smoltz | Juan Cruz | Tyler Yates | | 442 | 459 | -17 |
| 2007-07-29 | vs ATL | 107 | L 0-14 | 58-49 | 2 | 30,535 | Livan Hernandez | Tim Hudson | Tim Hudson | Livan Hernandez | | 442 | 473 | -31 |
| 2007-07-31 | @ SDN | 108 | W 4-0 | 59-49 | 1 | 32,086 | Brandon Webb | Justin Germano | Brandon Webb | Justin Germano | | 446 | 473 | -27 |
| 2007-08-01 | @ SDN | 109 | W 9-5 | 60-49 | 1 | 30,416 | Micah Owings | David Wells | Jose Valverde | Heath Bell | | 455 | 478 | -23 |
| 2007-08-02 | @ SDN | 110 | L 0-11 | 60-50 | 1 | 37,119 | Yusmeiro Petit | Jake Peavy | Jake Peavy | Yusmeiro Petit | | 455 | 489 | -34 |
| 2007-08-03 | @ LAN | 111 | W 1-0 | 61-50 | 1 | 51,582 | Doug Davis | Chad Billingsley | Doug Davis | Chad Billingsley | Jose Valverde | 456 | 489 | -33 |
| 2007-08-04 | @ LAN | 112 | W 8-7 | 62-50 | 1 | 52,921 | Livan Hernandez | Derek Lowe | Livan Hernandez | Derek Lowe | Jose Valverde | 464 | 496 | -32 |
| 2007-08-05 | @ LAN | 113 | W 3-0 | 63-50 | 1 | 48,803 | Brandon Webb | Brad Penny | Brandon Webb | Brad Penny | | 467 | 496 | -29 |
| 2007-08-07 | vs PIT | 114 | L 3-8 | 63-51 | 1 | 25,340 | Micah Owings | Tom Gorzelanny | Tom Gorzelanny | Micah Owings | | 470 | 504 | -34 |
| 2007-08-08 | vs PIT | 115 | W 10-6 | 64-51 | 1 | 23,082 | Byung-Hyun Kim | Paul Maholm | Edgar Gonzalez | Paul Maholm | Jose Valverde | 480 | 510 | -30 |
| 2007-08-09 | vs PIT | 116 | W 4-2 | 65-51 | 1 | 22,316 | Doug Davis | Ian Snell | Doug Davis | Shawn Chacon | Jose Valverde | 484 | 512 | -28 |
| 2007-08-10 | vs WAS | 117 | W 11-4 | 66-51 | 1 | 31,110 | Livan Hernandez | Matt Chico | Livan Hernandez | Saul Rivera | | 495 | 516 | -21 |
| 2007-08-11 | vs WAS | 118 | W 1-0 | 67-51 | 1 | 33,121 | Brandon Webb | John Lannan | Brandon Webb | John Lannan | | 496 | 516 | -20 |
| 2007-08-12 | vs WAS | 119 | L 6-7 | 67-52 | 1 | 29,839 | Micah Owings | Michael Bacsik | Jon Rauch | Jose Valverde | Chad Cordero | 502 | 523 | -21 |
| 2007-08-14 | @ FLO | 120 | L 5-14 | 67-53 | 1 | 10,610 | Byung-Hyun Kim | Dontrelle Willis | Dontrelle Willis | Byung-Hyun Kim | | 507 | 537 | -30 |
| 2007-08-15 | @ FLO | 121 | W 9-6 | 68-53 | 1 | 11,472 | Doug Davis | Sergio Mitre | Doug Davis | Sergio Mitre | Jose Valverde | 516 | 543 | -27 |
| 2007-08-16 | @ FLO | 122 | W 5-4 | 69-53 | 1 | 11,516 | Livan Hernandez | Daniel Barone | Livan Hernandez | Daniel Barone | Jose Valverde | 521 | 547 | -26 |
| 2007-08-17 | @ ATL | 123 | W 4-0 | 70-53 | 1 | 33,248 | Brandon Webb | Lance Cormier | Brandon Webb | Lance Cormier | | 525 | 547 | -22 |
| 2007-08-18 | @ ATL | 124 | W 12-6 | 71-53 | 1 | 48,643 | Micah Owings | Buddy Carlyle | Micah Owings | Buddy Carlyle | | 537 | 553 | -16 |
| 2007-08-19 | @ ATL | 125 | L 2-6 | 71-54 | 1 | 30,818 | Yusmeiro Petit | John Smoltz | John Smoltz | Yusmeiro Petit | | 539 | 559 | -20 |
| 2007-08-20 | vs MIL | 126 | L 0-9 | 71-55 | 1 | 26,900 | Doug Davis | Yovani Gallardo | Yovani Gallardo | Doug Davis | Carlos Villanueva | 539 | 568 | -29 |
| 2007-08-21 | vs MIL | 127 | L 4-7 | 71-56 | 1 | 27,784 | Livan Hernandez | David Bush | David Bush | Livan Hernandez | Francisco Cordero | 543 | 575 | -32 |
| 2007-08-22 | vs MIL | 128 | W 3-2 | 72-56 | 1 | 31,720 | Brandon Webb | Jeff Suppan | Brandon Webb | Jeff Suppan | Jose Valverde | 546 | 577 | -31 |
| 2007-08-24 | vs CHN | 129 | L 2-6 | 72-57 | 1 | 36,700 | Micah Owings | Sean Marshall | Sean Marshall | Micah Owings | Ryan Dempster | 548 | 583 | -35 |
| 2007-08-25 | vs CHN | 130 | W 3-1 | 73-57 | 1 | 46,173 | Doug Davis | Ted Lilly | Doug Davis | Ted Lilly | Jose Valverde | 551 | 584 | -33 |
| 2007-08-26 | vs CHN | 131 | W 5-4 | 74-57 | 1 | 38,902 | Yusmeiro Petit | Jason Marquis | Edgar Gonzalez | Jason Marquis | Jose Valverde | 556 | 588 | -32 |
| 2007-08-27 | @ SDN | 132 | L 1-3 | 74-58 | 1 | 25,763 | Livan Hernandez | Jake Peavy | Jake Peavy | Livan Hernandez | Trevor Hoffman | 557 | 591 | -34 |
| 2007-08-28 | @ SDN | 133 | L 4-6 | 74-59 | 1 | 23,006 | Brandon Webb | Justin Germano | Justin Germano | Brandon Webb | Trevor Hoffman | 561 | 597 | -36 |
| 2007-08-29 | @ SDN | 134 | L 1-3 | 74-60 | 2 | 29,021 | Micah Owings | Greg Maddux | Kevin Cameron | Doug Slaten | Heath Bell | 562 | 600 | -38 |
| 2007-08-30 | @ SDN | 135 | W 8-7 | 75-60 | 1 | 28,554 | Doug Davis | Chris Young | Doug Davis | Chris Young | Jose Valverde | 570 | 607 | -37 |
| 2007-08-31 | vs COL | 136 | L 3-7 | 75-61 | 2 | 26,127 | Livan Hernandez | Ubaldo Jimenez | Matt Herges | Tony Pena | | 573 | 614 | -41 |
| 2007-09-01 | vs COL | 137 | W 13-7 | 76-61 | 2 | 29,119 | Dana Eveland | Elmer Dessens | Edgar Gonzalez | Elmer Dessens | | 586 | 621 | -35 |
| 2007-09-02 | vs COL | 138 | L 3-4 | 76-62 | 2 | 26,776 | Brandon Webb | Josh Fogg | Josh Fogg | Brandon Webb | Manuel Corpas | 589 | 625 | -36 |
| 2007-09-03 | vs SDN | 139 | L 2-10 | 76-63 | 2 | 30,531 | Micah Owings | Greg Maddux | Greg Maddux | Micah Owings | | 591 | 635 | -44 |
| 2007-09-04 | vs SDN | 140 | W 9-1 | 77-63 | 2 | 26,063 | Doug Davis | Chris Young | Doug Davis | Chris Young | | 600 | 636 | -36 |
| 2007-09-05 | vs SDN | 141 | W 9-6 | 78-63 | 1 | 28,065 | Livan Hernandez | Jake Peavy | Livan Hernandez | Jake Peavy | Jose Valverde | 609 | 642 | -33 |
| 2007-09-07 | vs SLN | 142 | W 4-2 | 79-63 | 1 | 31,225 | Brandon Webb | Adam Wainwright | Brandon Webb | Adam Wainwright | Jose Valverde | 613 | 644 | -31 |
| 2007-09-08 | vs SLN | 143 | W 9-8 | 80-63 | 1 | 45,931 | Micah Owings | Braden Looper | Dana Eveland | Todd Wellemeyer | Jose Valverde | 622 | 652 | -30 |
| 2007-09-09 | vs SLN | 144 | W 6-5 | 81-63 | 1 | 35,136 | Doug Davis | Brad Thompson | Yusmeiro Petit | Ryan Franklin | Jose Valverde | 628 | 657 | -29 |
| 2007-09-10 | @ SFN | 145 | W 5-3 | 82-63 | 1 | 33,498 | Livan Hernandez | Tim Lincecum | Jailen Peguero | Brad Hennessey | Tony Pena | 633 | 660 | -27 |
| 2007-09-11 | @ SFN | 146 | L 1-2 | 82-64 | 1 | 33,633 | Edgar Gonzalez | Kevin Correia | Tyler Walker | Bob Wickman | Brian Wilson | 634 | 662 | -28 |
| 2007-09-12 | @ SFN | 147 | W 9-4 | 83-64 | 1 | 37,083 | Brandon Webb | Jonathan Sanchez | Brandon Webb | Jonathan Sanchez | | 643 | 666 | -23 |
| 2007-09-14 | @ LAN | 148 | L 4-7 | 83-65 | 1 | 54,014 | Doug Davis | Brad Penny | Brad Penny | Doug Davis | Takashi Saito | 647 | 673 | -26 |
| 2007-09-15 | @ LAN | 149 | L 2-6 | 83-66 | 1 | 48,366 | Livan Hernandez | Derek Lowe | Derek Lowe | Livan Hernandez | | 649 | 679 | -30 |
| 2007-09-16 | @ LAN | 150 | W 6-1 | 84-66 | 1 | 51,460 | Edgar Gonzalez | Esteban Loaiza | Edgar Gonzalez | Esteban Loaiza | | 655 | 680 | -25 |
| 2007-09-17 | vs SFN | 151 | L 5-8 | 84-67 | 1 | 31,122 | Brandon Webb | Kevin Correia | Scott Munter | Tony Pena | Brian Wilson | 660 | 688 | -28 |
| 2007-09-18 | vs SFN | 152 | W 5-0 | 85-67 | 1 | 44,220 | Micah Owings | Jonathan Sanchez | Micah Owings | Jonathan Sanchez | | 665 | 688 | -23 |
| 2007-09-19 | vs SFN | 153 | W 6-4 | 86-67 | 1 | 42,855 | Doug Davis | Barry Zito | Juan Cruz | Barry Zito | Jose Valverde | 671 | 692 | -21 |
| 2007-09-21 | vs LAN | 154 | W 12-3 | 87-67 | 1 | 37,753 | Livan Hernandez | Esteban Loaiza | Livan Hernandez | Esteban Loaiza | | 683 | 695 | -12 |
| 2007-09-22 | vs LAN | 155 | W 6-2 | 88-67 | 1 | 47,673 | Brandon Webb | David Wells | Brandon Webb | David Wells | | 689 | 697 | -8 |
| 2007-09-23 | vs LAN | 156 | L 1-7 | 88-68 | 1 | 43,372 | Edgar Gonzalez | Chad Billingsley | Chad Billingsley | Edgar Gonzalez | | 690 | 704 | -14 |
| 2007-09-25 | @ PIT | 157 | L 5-6 | 88-69 | 1 | 14,569 | Doug Davis | Ian Snell | Salomon Torres | Brandon Lyon | Matt Capps | 695 | 710 | -15 |
| 2007-09-26 | @ PIT | 158 | L 1-5 | 88-70 | 1 | 16,289 | Livan Hernandez | Matt Morris | Matt Morris | Livan Hernandez | | 696 | 715 | -19 |
| 2007-09-27 | @ PIT | 159 | W 8-0 | 89-70 | 1 | 11,335 | Micah Owings | John Van Benschoten | Micah Owings | John Van Benschoten | | 704 | 715 | -11 |
| 2007-09-28 | @ COL | 160 | W 4-2 | 90-70 | 1 | 48,190 | Brandon Webb | Jeff Francis | Brandon Webb | Jeff Francis | Jose Valverde | 708 | 717 | -9 |
| 2007-09-29 | @ COL | 161 | L 1-11 | 90-71 | 1 | 47,368 | Edgar Gonzalez | Mark Redman | Mark Redman | Edgar Gonzalez | | 709 | 728 | -19 |
| 2007-09-30 | @ COL | 162 | L 3-4 | 90-72 | 1 | 46,375 | Yusmeiro Petit | Ubaldo Jimenez | Brian Fuentes | Dustin Nippert | Manuel Corpas | 712 | 732 | -20 |