| 2007-04-02 | vs BOS | 1 | W 7-1 | 1-0 | 2 | 41,257 | Gil Meche | Curt Schilling | Gil Meche | Curt Schilling | | 7 | 1 | 6 |
| 2007-04-04 | vs BOS | 2 | L 1-7 | 1-1 | 4 | 22,348 | Odalis Perez | Josh Beckett | Josh Beckett | Odalis Perez | | 8 | 8 | 0 |
| 2007-04-05 | vs BOS | 3 | L 1-4 | 1-2 | 5 | 23,170 | Zack Greinke | Daisuke Matsuzaka | Daisuke Matsuzaka | Zack Greinke | Jonathan Papelbon | 9 | 12 | -3 |
| 2007-04-06 | vs DET | 4 | W 3-1 | 2-2 | 3 | 13,330 | Jorge de la Rosa | Justin Verlander | Jorge de la Rosa | Jose Mesa | David Riske | 12 | 13 | -1 |
| 2007-04-07 | vs DET | 5 | L 5-6 | 2-3 | 5 | 13,899 | Gil Meche | Mike Maroth | Mike Maroth | Gil Meche | Todd Jones | 17 | 19 | -2 |
| 2007-04-08 | vs DET | 6 | L 2-3 | 2-4 | 5 | 13,109 | Brandon Duckworth | Jeremy Bonderman | Fernando Rodney | David Riske | Todd Jones | 19 | 22 | -3 |
| 2007-04-09 | @ TOR | 7 | L 1-9 | 2-5 | 5 | 50,125 | Odalis Perez | A.J. Burnett | A.J. Burnett | Odalis Perez | | 20 | 31 | -11 |
| 2007-04-10 | @ TOR | 8 | W 6-3 | 3-5 | 5 | 22,106 | Zack Greinke | Josh Towers | Zack Greinke | Josh Towers | Joakim Soria | 26 | 34 | -8 |
| 2007-04-11 | @ TOR | 9 | L 4-7 | 3-6 | 5 | 15,218 | Jorge de la Rosa | Gustavo Chacin | Gustavo Chacin | Jorge de la Rosa | B.J. Ryan | 30 | 41 | -11 |
| 2007-04-12 | @ BAL | 10 | L 1-2 | 3-7 | 5 | 13,229 | Gil Meche | Steve Trachsel | Chris Ray | Jason Standridge | | 31 | 43 | -12 |
| 2007-04-13 | @ BAL | 11 | L 1-8 | 3-8 | 5 | 20,922 | Brandon Duckworth | Erik Bedard | Erik Bedard | Brandon Duckworth | | 32 | 51 | -19 |
| 2007-04-14 | @ BAL | 12 | L 4-6 | 3-9 | 5 | 15,244 | Odalis Perez | Daniel Cabrera | Scott Williamson | Joel Peralta | Chris Ray | 36 | 57 | -21 |
| 2007-04-16 | @ DET | 13 | L 5-12 | 3-10 | 5 | 21,832 | Zack Greinke | Justin Verlander | Justin Verlander | Zack Greinke | | 41 | 69 | -28 |
| 2007-04-17 | @ DET | 14 | L 6-7 | 3-11 | 5 | 21,263 | Jorge de la Rosa | Mike Maroth | Wil Ledezma | David Riske | Todd Jones | 47 | 76 | -29 |
| 2007-04-18 | @ DET | 15 | W 4-3 | 4-11 | 5 | 27,945 | Gil Meche | Jeremy Bonderman | Joakim Soria | Fernando Rodney | | 51 | 79 | -28 |
| 2007-04-20 | vs MIN | 16 | W 11-7 | 5-11 | 5 | 31,813 | Odalis Perez | Sidney Ponson | Odalis Perez | Sidney Ponson | David Riske | 62 | 86 | -24 |
| 2007-04-21 | vs MIN | 17 | L 5-7 | 5-12 | 5 | 20,566 | Zack Greinke | Boof Bonser | Pat Neshek | Joel Peralta | Joe Nathan | 67 | 93 | -26 |
| 2007-04-22 | vs MIN | 18 | W 3-1 | 6-12 | 5 | 14,801 | Jorge de la Rosa | Ramon Ortiz | Jorge de la Rosa | Ramon Ortiz | Joakim Soria | 70 | 94 | -24 |
| 2007-04-23 | vs CHA | 19 | L 4-7 | 6-13 | 5 | 12,265 | Gil Meche | Mark Buehrle | Mark Buehrle | Jimmy Gobble | Bobby Jenks | 74 | 101 | -27 |
| 2007-04-24 | vs CHA | 20 | L 7-9 | 6-14 | 5 | 14,907 | Brian Bannister | Javier Vazquez | Boone Logan | Joakim Soria | Bobby Jenks | 81 | 110 | -29 |
| 2007-04-25 | @ MIN | 21 | W 4-3 | 7-14 | 5 | 21,496 | Odalis Perez | Sidney Ponson | Odalis Perez | Sidney Ponson | Joakim Soria | 85 | 113 | -28 |
| 2007-04-26 | @ MIN | 22 | L 0-1 | 7-15 | 5 | 18,520 | Zack Greinke | Boof Bonser | Juan Rincon | Todd Wellemeyer | | 85 | 114 | -29 |
| 2007-04-27 | @ SEA | 23 | L 4-7 | 7-16 | 5 | 37,281 | Jorge de la Rosa | Horacio Ramirez | Horacio Ramirez | Jorge de la Rosa | J.J. Putz | 89 | 121 | -32 |
| 2007-04-28 | @ SEA | 24 | W 8-3 | 8-16 | 5 | 32,441 | Gil Meche | Jeff Weaver | Gil Meche | Jeff Weaver | Brandon Duckworth | 97 | 124 | -27 |
| 2007-04-29 | @ SEA | 25 | L 1-5 | 8-17 | 5 | 26,019 | Brian Bannister | Cha-Seung Baek | Brandon Morrow | Brian Bannister | | 98 | 129 | -31 |
| 2007-04-30 | vs ANA | 26 | L 1-3 | 8-18 | 5 | 10,866 | Odalis Perez | John Lackey | John Lackey | Odalis Perez | Francisco Rodriguez | 99 | 132 | -33 |
| 2007-05-01 | vs ANA | 27 | L 5-7 | 8-19 | 5 | 11,225 | Zack Greinke | Bartolo Colon | Bartolo Colon | Zack Greinke | Francisco Rodriguez | 104 | 139 | -35 |
| 2007-05-02 | vs ANA | 28 | W 3-1 | 9-19 | 5 | 9,697 | Jorge de la Rosa | Ervin Santana | Jorge de la Rosa | Ervin Santana | Joakim Soria | 107 | 140 | -33 |
| 2007-05-03 | vs ANA | 29 | W 5-2 | 10-19 | 5 | 12,683 | Gil Meche | Jered Weaver | Gil Meche | Jered Weaver | Joakim Soria | 112 | 142 | -30 |
| 2007-05-04 | vs DET | 30 | L 3-6 | 10-20 | 5 | 17,614 | Brian Bannister | Justin Verlander | Justin Verlander | Brian Bannister | Todd Jones | 115 | 148 | -33 |
| 2007-05-05 | vs DET | 31 | L 5-7 | 10-21 | 5 | 26,070 | Odalis Perez | Mike Maroth | Jose Mesa | Brandon Duckworth | Todd Jones | 120 | 155 | -35 |
| 2007-05-06 | vs DET | 32 | L 4-13 | 10-22 | 5 | 17,034 | Zack Greinke | Chad Durbin | Chad Durbin | Zack Greinke | | 124 | 168 | -44 |
| 2007-05-08 | vs OAK | 33 | L 1-6 | 10-23 | 5 | 10,989 | Jorge de la Rosa | Chad Gaudin | Chad Gaudin | Jorge de la Rosa | | 125 | 174 | -49 |
| 2007-05-09 | vs OAK | 34 | W 3-2 | 11-23 | 5 | 10,974 | Gil Meche | Dan Haren | Jimmy Gobble | Justin Duchscherer | Joakim Soria | 128 | 176 | -48 |
| 2007-05-10 | vs OAK | 35 | L 3-17 | 11-24 | 5 | 31,006 | Luke Hudson | Joe Kennedy | Joe Kennedy | Luke Hudson | | 131 | 193 | -62 |
| 2007-05-11 | @ CHA | 36 | L 1-2 | 11-25 | 5 | 34,522 | Odalis Perez | Jon Garland | Jon Garland | Odalis Perez | Bobby Jenks | 132 | 195 | -63 |
| 2007-05-12 | @ CHA | 37 | L 4-5 | 11-26 | 5 | 36,702 | Scott Elarton | Mark Buehrle | Mike MacDougal | Brandon Duckworth | | 136 | 200 | -64 |
| 2007-05-13 | @ CHA | 38 | W 11-1 | 12-26 | 5 | 34,468 | Jorge de la Rosa | Javier Vazquez | Jorge de la Rosa | Javier Vazquez | | 147 | 201 | -54 |
| 2007-05-14 | @ OAK | 39 | W 2-1 | 13-26 | 5 | 12,477 | Gil Meche | Dan Haren | Jimmy Gobble | Justin Duchscherer | Joakim Soria | 149 | 202 | -53 |
| 2007-05-15 | @ OAK | 40 | L 4-5 | 13-27 | 5 | 14,966 | Brian Bannister | Joe Kennedy | Lenny DiNardo | Joakim Soria | | 153 | 207 | -54 |
| 2007-05-16 | @ OAK | 41 | W 4-3 | 14-27 | 5 | 16,242 | Odalis Perez | Joe Blanton | Jimmy Gobble | Kiko Calero | David Riske | 157 | 210 | -53 |
| 2007-05-17 | @ OAK | 42 | W 7-4 | 15-27 | 5 | 21,037 | Scott Elarton | Dallas Braden | Scott Elarton | Dallas Braden | Joakim Soria | 164 | 214 | -50 |
| 2007-05-18 | @ COL | 43 | W 5-2 | 16-27 | 5 | 22,399 | Jorge de la Rosa | Jeff Francis | Brandon Duckworth | Manuel Corpas | Joakim Soria | 169 | 216 | -47 |
| 2007-05-19 | @ COL | 44 | L 4-6 | 16-28 | 5 | 24,017 | Gil Meche | Taylor Buchholz | Taylor Buchholz | Gil Meche | Brian Fuentes | 173 | 222 | -49 |
| 2007-05-20 | @ COL | 45 | W 10-5 | 17-28 | 5 | 25,829 | Brian Bannister | Jason Hirsh | Joel Peralta | Ramon Ramirez | | 183 | 227 | -44 |
| 2007-05-22 | vs CLE | 46 | W 4-3 | 18-28 | 5 | 19,776 | Odalis Perez | Fausto Carmona | Zack Greinke | Tom Mastny | Joakim Soria | 187 | 230 | -43 |
| 2007-05-23 | vs CLE | 47 | W 11-7 | 19-28 | 5 | 11,506 | Scott Elarton | Cliff Lee | Brandon Duckworth | Cliff Lee | | 198 | 237 | -39 |
| 2007-05-24 | vs CLE | 48 | L 3-10 | 19-29 | 5 | 11,681 | Jorge de la Rosa | Jeremy Sowers | Jeremy Sowers | Jorge de la Rosa | | 201 | 247 | -46 |
| 2007-05-25 | vs SEA | 49 | L 2-10 | 19-30 | 5 | 28,651 | Gil Meche | Felix Hernandez | Felix Hernandez | Gil Meche | | 203 | 257 | -54 |
| 2007-05-26 | vs SEA | 50 | L 1-9 | 19-31 | 5 | 21,138 | Brian Bannister | Cha-Seung Baek | Cha-Seung Baek | Brian Bannister | | 204 | 266 | -62 |
| 2007-05-27 | vs SEA | 51 | L 4-7 | 19-32 | 5 | 16,091 | Odalis Perez | Jarrod Washburn | Jarrod Washburn | Odalis Perez | J.J. Putz | 208 | 273 | -65 |
| 2007-05-28 | vs BAL | 52 | L 1-9 | 19-33 | 5 | 14,758 | Scott Elarton | Steve Trachsel | Steve Trachsel | Scott Elarton | | 209 | 282 | -73 |
| 2007-05-29 | vs BAL | 53 | L 2-6 | 19-34 | 5 | 13,556 | Jorge de la Rosa | Jeremy Guthrie | Jeremy Guthrie | Jorge de la Rosa | | 211 | 288 | -77 |
| 2007-05-30 | vs BAL | 54 | L 0-3 | 19-35 | 5 | 10,513 | Gil Meche | Erik Bedard | Erik Bedard | Gil Meche | Chris Ray | 211 | 291 | -80 |
| 2007-06-01 | @ TBA | 55 | W 4-1 | 20-35 | 5 | 12,032 | Brian Bannister | Scott Kazmir | Brian Bannister | Scott Kazmir | Octavio Dotel | 215 | 292 | -77 |
| 2007-06-02 | @ TBA | 56 | W 9-4 | 21-35 | 5 | 14,403 | Odalis Perez | Edwin Jackson | Odalis Perez | Edwin Jackson | | 224 | 296 | -72 |
| 2007-06-03 | @ TBA | 57 | L 1-5 | 21-36 | 5 | 12,220 | Scott Elarton | J.P. Howell | J.P. Howell | Scott Elarton | | 225 | 301 | -76 |
| 2007-06-04 | @ TBA | 58 | L 2-4 | 21-37 | 5 | 9,435 | Gil Meche | James Shields | James Shields | Gil Meche | Alberto Reyes | 227 | 305 | -78 |
| 2007-06-05 | @ CLE | 59 | L 0-1 | 21-38 | 5 | 14,036 | Jorge de la Rosa | CC Sabathia | CC Sabathia | Jorge de la Rosa | | 227 | 306 | -79 |
| 2007-06-06 | @ CLE | 60 | W 4-3 | 22-38 | 5 | 17,632 | Brian Bannister | Paul Byrd | Brian Bannister | Paul Byrd | Octavio Dotel | 231 | 309 | -78 |
| 2007-06-07 | @ CLE | 61 | L 3-8 | 22-39 | 5 | 19,315 | Odalis Perez | Fausto Carmona | Fausto Carmona | Odalis Perez | | 234 | 317 | -83 |
| 2007-06-08 | vs PHI | 62 | W 8-4 | 23-39 | 5 | 19,121 | Scott Elarton | Freddy Garcia | Scott Elarton | Freddy Garcia | Octavio Dotel | 242 | 321 | -79 |
| 2007-06-09 | vs PHI | 63 | L 0-4 | 23-40 | 5 | 23,734 | Gil Meche | Jon Lieber | Jon Lieber | Gil Meche | | 242 | 325 | -83 |
| 2007-06-10 | vs PHI | 64 | W 17-5 | 24-40 | 5 | 16,034 | Jorge de la Rosa | Jamie Moyer | Zack Greinke | Jamie Moyer | | 259 | 330 | -71 |
| 2007-06-12 | vs SLN | 65 | W 8-1 | 25-40 | 5 | 29,354 | Brian Bannister | Brad Thompson | Brian Bannister | Brad Thompson | | 267 | 331 | -64 |
| 2007-06-13 | vs SLN | 66 | L 3-7 | 25-41 | 5 | 25,555 | Odalis Perez | Adam Wainwright | Adam Wainwright | Odalis Perez | | 270 | 338 | -68 |
| 2007-06-14 | vs SLN | 67 | W 17-8 | 26-41 | 5 | 28,837 | Scott Elarton | Kip Wells | Zack Greinke | Kip Wells | | 287 | 346 | -59 |
| 2007-06-15 | vs FLO | 68 | W 6-2 | 27-41 | 5 | 28,015 | Gil Meche | Sergio Mitre | Gil Meche | Sergio Mitre | Octavio Dotel | 293 | 348 | -55 |
| 2007-06-16 | vs FLO | 69 | L 8-9 | 27-42 | 5 | 24,323 | Jorge de la Rosa | Rick Vanden Hurk | Rick Vanden Hurk | Jorge de la Rosa | Kevin Gregg | 301 | 357 | -56 |
| 2007-06-17 | vs FLO | 70 | W 5-4 | 28-42 | 5 | 19,433 | Brian Bannister | Scott Olsen | Brian Bannister | Scott Olsen | Octavio Dotel | 306 | 361 | -55 |
| 2007-06-18 | @ SLN | 71 | W 5-3 | 29-42 | 5 | 43,524 | Odalis Perez | Adam Wainwright | Odalis Perez | Adam Wainwright | Octavio Dotel | 311 | 364 | -53 |
| 2007-06-19 | @ SLN | 72 | L 1-5 | 29-43 | 5 | 42,712 | Scott Elarton | Brad Thompson | Brad Thompson | Scott Elarton | | 312 | 369 | -57 |
| 2007-06-20 | @ SLN | 73 | L 6-7 | 29-44 | 5 | 42,623 | Gil Meche | Todd Wellemeyer | Kip Wells | Jorge de la Rosa | | 318 | 376 | -58 |
| 2007-06-22 | @ MIL | 74 | L 6-11 | 29-45 | 5 | 36,328 | Jorge de la Rosa | Jeff Suppan | Jeff Suppan | Jorge de la Rosa | | 324 | 387 | -63 |
| 2007-06-23 | @ MIL | 75 | L 1-7 | 29-46 | 5 | 41,721 | Brian Bannister | David Bush | David Bush | Brian Bannister | | 325 | 394 | -69 |
| 2007-06-24 | @ MIL | 76 | W 4-3 | 30-46 | 5 | 44,064 | Odalis Perez | Yovani Gallardo | David Riske | Jose Capellan | Jimmy Gobble | 329 | 397 | -68 |
| 2007-06-25 | @ ANA | 77 | W 5-3 | 31-46 | 5 | 43,895 | John Thomson | John Lackey | John Thomson | John Lackey | Octavio Dotel | 334 | 400 | -66 |
| 2007-06-26 | @ ANA | 78 | W 12-4 | 32-46 | 5 | 44,002 | Gil Meche | Ervin Santana | Gil Meche | Ervin Santana | | 346 | 404 | -58 |
| 2007-06-27 | @ ANA | 79 | W 1-0 | 33-46 | 5 | 41,269 | Jorge de la Rosa | Jered Weaver | Jorge de la Rosa | Jered Weaver | Octavio Dotel | 347 | 404 | -57 |
| 2007-06-29 | vs CHA | 80 | W 8-1 | 34-46 | 5 | 20,525 | Brian Bannister | Jose Contreras | Brian Bannister | Jose Contreras | Zack Greinke | 355 | 405 | -50 |
| 2007-06-30 | vs CHA | 81 | L 1-3 | 34-47 | 5 | 25,119 | Odalis Perez | John Danks | Ryan Bukvich | Octavio Dotel | Bobby Jenks | 356 | 408 | -52 |
| 2007-07-01 | vs CHA | 82 | L 1-3 | 34-48 | 5 | 23,004 | John Thomson | Jon Garland | Jon Garland | John Thomson | Bobby Jenks | 357 | 411 | -54 |
| 2007-07-02 | vs SEA | 83 | W 3-2 | 35-48 | 5 | 13,257 | Gil Meche | Felix Hernandez | Octavio Dotel | Brandon Morrow | | 360 | 413 | -53 |
| 2007-07-03 | vs SEA | 84 | W 17-3 | 36-48 | 5 | 28,140 | Jorge de la Rosa | Ryan Feierabend | Jorge de la Rosa | Ryan Feierabend | | 377 | 416 | -39 |
| 2007-07-04 | vs SEA | 85 | L 0-4 | 36-49 | 5 | 27,497 | Brian Bannister | Jarrod Washburn | Jarrod Washburn | Brian Bannister | J.J. Putz | 377 | 420 | -43 |
| 2007-07-06 | vs TBA | 86 | L 5-6 | 36-50 | 5 | 18,753 | Odalis Perez | James Shields | James Shields | Odalis Perez | Gary Glover | 382 | 426 | -44 |
| 2007-07-07 | vs TBA | 87 | W 8-7 | 37-50 | 5 | 20,458 | Gil Meche | Andy Sonnanstine | Octavio Dotel | Shawn Camp | | 390 | 433 | -43 |
| 2007-07-08 | vs TBA | 88 | W 12-4 | 38-50 | 5 | 14,726 | Jorge de la Rosa | Scott Kazmir | Jorge de la Rosa | Scott Kazmir | | 402 | 437 | -35 |
| 2007-07-13 | @ CLE | 89 | L 4-5 | 38-51 | 5 | 32,624 | Odalis Perez | Jake Westbrook | Joe Borowski | Zack Greinke | | 406 | 442 | -36 |
| 2007-07-14 | @ CLE | 90 | W 6-5 | 39-51 | 5 | 31,599 | Gil Meche | CC Sabathia | Gil Meche | CC Sabathia | Octavio Dotel | 412 | 447 | -35 |
| 2007-07-15 | @ CLE | 91 | L 3-5 | 39-52 | 5 | 29,657 | Jorge de la Rosa | Fausto Carmona | Fausto Carmona | Jorge de la Rosa | Joe Borowski | 415 | 452 | -37 |
| 2007-07-16 | @ BOS | 92 | L 0-4 | 39-53 | 5 | 37,099 | Brian Bannister | Kason Gabbard | Kason Gabbard | Brian Bannister | | 415 | 456 | -41 |
| 2007-07-17 | @ BOS | 93 | W 9-3 | 40-53 | 5 | 37,001 | Leo Nunez | Tim Wakefield | Jimmy Gobble | Tim Wakefield | | 424 | 459 | -35 |
| 2007-07-18 | @ BOS | 94 | W 6-5 | 41-53 | 5 | 36,681 | Odalis Perez | Julian Tavarez | Odalis Perez | Julian Tavarez | Octavio Dotel | 430 | 464 | -34 |
| 2007-07-20 | @ DET | 95 | W 10-2 | 42-53 | 5 | 43,200 | Gil Meche | Kenny Rogers | Gil Meche | Kenny Rogers | | 440 | 466 | -26 |
| 2007-07-21 | @ DET | 96 | L 8-10 | 42-54 | 5 | 43,408 | Jorge de la Rosa | Justin Verlander | Chad Durbin | Joakim Soria | | 448 | 476 | -28 |
| 2007-07-22 | @ DET | 97 | W 5-2 | 43-54 | 5 | 42,201 | Brian Bannister | Nate Robertson | Brian Bannister | Nate Robertson | | 453 | 478 | -25 |
| 2007-07-23 | vs NYA | 98 | L 2-9 | 43-55 | 5 | 30,476 | Odalis Perez | Roger Clemens | Roger Clemens | Odalis Perez | | 455 | 487 | -32 |
| 2007-07-24 | vs NYA | 99 | L 4-9 | 43-56 | 5 | 38,212 | Scott Elarton | Chien-Ming Wang | Chien-Ming Wang | Scott Elarton | | 459 | 496 | -37 |
| 2007-07-25 | vs NYA | 100 | L 1-7 | 43-57 | 5 | 28,460 | Gil Meche | Mike Mussina | Mike Mussina | Gil Meche | | 460 | 503 | -43 |
| 2007-07-26 | vs NYA | 101 | W 7-0 | 44-57 | 5 | 37,036 | Jorge de la Rosa | Kei Igawa | Jorge de la Rosa | Kei Igawa | | 467 | 503 | -36 |
| 2007-07-27 | vs TEX | 102 | W 6-1 | 45-57 | 5 | 21,730 | Brian Bannister | Jamey Wright | Brian Bannister | Jamey Wright | | 473 | 504 | -31 |
| 2007-07-28 | vs TEX | 103 | W 6-5 | 46-57 | 5 | 27,700 | Odalis Perez | Kevin Millwood | Odalis Perez | Kevin Millwood | Octavio Dotel | 479 | 509 | -30 |
| 2007-07-29 | vs TEX | 104 | W 10-0 | 47-57 | 5 | 15,638 | Leo Nunez | Kameron Loe | Leo Nunez | Kameron Loe | Joel Peralta | 489 | 509 | -20 |
| 2007-07-30 | @ MIN | 105 | L 1-3 | 47-58 | 5 | 23,628 | Gil Meche | Scott Baker | Scott Baker | Gil Meche | Joe Nathan | 490 | 512 | -22 |
| 2007-07-31 | @ MIN | 106 | L 3-5 | 47-59 | 5 | 22,890 | Jorge de la Rosa | Carlos Silva | Carlos Silva | Jorge de la Rosa | Joe Nathan | 493 | 517 | -24 |
| 2007-08-01 | @ MIN | 107 | W 5-3 | 48-59 | 5 | 24,880 | Brian Bannister | Boof Bonser | Zack Greinke | Juan Rincon | Joakim Soria | 498 | 520 | -22 |
| 2007-08-03 | @ NYA | 108 | L 1-7 | 48-60 | 5 | 54,246 | Odalis Perez | Chien-Ming Wang | Chien-Ming Wang | Odalis Perez | | 499 | 527 | -28 |
| 2007-08-04 | @ NYA | 109 | L 8-16 | 48-61 | 5 | 54,056 | Kyle Davies | Phil Hughes | Mike Myers | John Bale | | 507 | 543 | -36 |
| 2007-08-05 | @ NYA | 110 | L 5-8 | 48-62 | 5 | 54,525 | Gil Meche | Mike Mussina | Mike Mussina | Gil Meche | Mariano Rivera | 512 | 551 | -39 |
| 2007-08-07 | vs MIN | 111 | W 5-1 | 49-62 | 5 | 15,648 | Brian Bannister | Boof Bonser | Brian Bannister | Boof Bonser | | 517 | 552 | -35 |
| 2007-08-08 | vs MIN | 112 | L 4-11 | 49-63 | 5 | 21,503 | Odalis Perez | Johan Santana | Johan Santana | Odalis Perez | | 521 | 563 | -42 |
| 2007-08-09 | vs MIN | 113 | W 1-0 | 50-63 | 5 | 14,569 | Kyle Davies | Matt Garza | Kyle Davies | Matt Garza | Joakim Soria | 522 | 563 | -41 |
| 2007-08-10 | vs TOR | 114 | L 1-2 | 50-64 | 5 | 21,276 | Gil Meche | Shaun Marcum | Shaun Marcum | Gil Meche | Jeremy Accardo | 523 | 565 | -42 |
| 2007-08-11 | vs TOR | 115 | W 4-1 | 51-64 | 5 | 25,934 | Leo Nunez | Dustin McGowan | Leo Nunez | Dustin McGowan | Joakim Soria | 527 | 566 | -39 |
| 2007-08-12 | vs TOR | 116 | L 1-4 | 51-65 | 5 | 18,381 | Brian Bannister | A.J. Burnett | A.J. Burnett | Brian Bannister | Jeremy Accardo | 528 | 570 | -42 |
| 2007-08-13 | vs TOR | 117 | W 6-2 | 52-65 | 5 | 14,845 | Odalis Perez | Jesse Litsch | Odalis Perez | Jesse Litsch | | 534 | 572 | -38 |
| 2007-08-14 | @ TEX | 118 | L 3-5 | 52-66 | 5 | 23,906 | Kyle Davies | Kevin Millwood | Kevin Millwood | Kyle Davies | C.J. Wilson | 537 | 577 | -40 |
| 2007-08-15 | @ TEX | 119 | L 3-4 | 52-67 | 5 | 24,529 | Gil Meche | Vicente Padilla | Mike Wood | Gil Meche | C.J. Wilson | 540 | 581 | -41 |
| 2007-08-16 | @ TEX | 120 | W 6-2 | 53-67 | 5 | 22,674 | Leo Nunez | John Rheinecker | Ryan Braun | Willie Eyre | | 546 | 583 | -37 |
| 2007-08-17 | @ OAK | 121 | W 9-2 | 54-67 | 5 | 18,185 | Brian Bannister | Dan Meyer | Brian Bannister | Dan Meyer | | 555 | 585 | -30 |
| 2007-08-18 | @ OAK | 122 | W 7-3 | 55-67 | 4 | 24,638 | Odalis Perez | Chad Gaudin | Odalis Perez | Chad Gaudin | | 562 | 588 | -26 |
| 2007-08-19 | @ OAK | 123 | L 1-6 | 55-68 | 4 | 26,445 | Kyle Davies | Lenny DiNardo | Lenny DiNardo | Kyle Davies | | 563 | 594 | -31 |
| 2007-08-20 | @ CHA | 124 | L 3-4 | 55-69 | 5 | 35,391 | Gil Meche | Mark Buehrle | Matt Thornton | David Riske | Bobby Jenks | 566 | 598 | -32 |
| 2007-08-21 | @ CHA | 125 | L 2-5 | 55-70 | 5 | 35,309 | Leo Nunez | Javier Vazquez | Javier Vazquez | Leo Nunez | Bobby Jenks | 568 | 603 | -35 |
| 2007-08-22 | @ CHA | 126 | W 7-6 | 56-70 | 5 | 31,739 | Brian Bannister | Jose Contreras | Brian Bannister | Jose Contreras | | 575 | 609 | -34 |
| 2007-08-24 | vs CLE | 127 | W 2-1 | 57-70 | 4 | 25,640 | Zack Greinke | CC Sabathia | John Bale | CC Sabathia | Joakim Soria | 577 | 610 | -33 |
| 2007-08-25 | vs CLE | 128 | L 4-9 | 57-71 | 4 | 23,167 | Kyle Davies | Aaron Laffey | Aaron Laffey | Kyle Davies | | 581 | 619 | -38 |
| 2007-08-26 | vs CLE | 129 | L 3-5 | 57-72 | 4 | 18,268 | Gil Meche | Fausto Carmona | Rafael Betancourt | Joel Peralta | Joe Borowski | 584 | 624 | -40 |
| 2007-08-28 | vs DET | 130 | W 6-3 | 58-72 | 4 | 16,193 | Brian Bannister | Nate Robertson | Brian Bannister | Nate Robertson | | 590 | 627 | -37 |
| 2007-08-29 | vs DET | 131 | W 5-0 | 59-72 | 4 | 11,628 | Zack Greinke | Andrew Miller | Ryan Braun | Andrew Miller | David Riske | 595 | 627 | -32 |
| 2007-08-30 | vs DET | 132 | L 1-6 | 59-73 | 4 | 11,196 | Leo Nunez | Jeremy Bonderman | Jeremy Bonderman | Leo Nunez | | 596 | 633 | -37 |
| 2007-08-31 | @ MIN | 133 | W 9-4 | 59-74 | 4 | 15,736 | Kyle Davies | Matt Garza | Kyle Davies | Matt Garza | | 605 | 637 | -32 |
| 2007-08-31 | @ MIN | 134 | L 0-5 | 59-74 | 4 | 24,986 | Gil Meche | Scott Baker | Scott Baker | Gil Meche | | 605 | 642 | -37 |
| 2007-09-01 | @ MIN | 135 | L 4-6 | 60-74 | 4 | 21,738 | Brandon Duckworth | Carlos Silva | Carlos Silva | Brandon Duckworth | Joe Nathan | 609 | 648 | -39 |
| 2007-09-02 | @ MIN | 136 | W 8-1 | 61-74 | 4 | 26,454 | Brian Bannister | Boof Bonser | Brian Bannister | Boof Bonser | | 617 | 649 | -32 |
| 2007-09-03 | @ TEX | 137 | W 8-1 | 62-74 | 4 | 19,214 | Zack Greinke | Kameron Loe | Zack Greinke | Kameron Loe | | 625 | 650 | -25 |
| 2007-09-04 | @ TEX | 138 | L 8-9 | 62-75 | 4 | 18,892 | Billy Buckner | Kevin Millwood | John Rheinecker | Leo Nunez | C.J. Wilson | 633 | 659 | -26 |
| 2007-09-05 | @ TEX | 139 | L 2-3 | 62-76 | 4 | 17,232 | Kyle Davies | Vicente Padilla | Vicente Padilla | Kyle Davies | Joaquin Benoit | 635 | 662 | -27 |
| 2007-09-07 | vs NYA | 140 | L 2-3 | 62-77 | 4 | 27,462 | Gil Meche | Ian Kennedy | Kyle Farnsworth | Neal Musser | Mariano Rivera | 637 | 665 | -28 |
| 2007-09-08 | vs NYA | 141 | L 5-11 | 62-78 | 4 | 35,518 | Brian Bannister | Andy Pettitte | Andy Pettitte | Brian Bannister | | 642 | 676 | -34 |
| 2007-09-09 | vs NYA | 142 | L 3-6 | 62-79 | 4 | 24,910 | Zack Greinke | Chien-Ming Wang | Chien-Ming Wang | Brandon Duckworth | Mariano Rivera | 645 | 682 | -37 |
| 2007-09-10 | vs MIN | 143 | L 2-4 | 62-80 | 4 | 10,525 | Billy Buckner | Boof Bonser | Boof Bonser | Billy Buckner | Joe Nathan | 647 | 686 | -39 |
| 2007-09-11 | vs MIN | 144 | L 3-6 | 62-81 | 4 | 12,891 | Kyle Davies | Scott Baker | Scott Baker | Kyle Davies | Joe Nathan | 650 | 692 | -42 |
| 2007-09-12 | vs MIN | 145 | W 6-3 | 63-81 | 4 | 10,102 | Gil Meche | Carlos Silva | Gil Meche | Carlos Silva | | 656 | 695 | -39 |
| 2007-09-14 | @ CLE | 146 | L 4-5 | 63-82 | 4 | 35,230 | Brian Bannister | CC Sabathia | Joe Borowski | David Riske | | 660 | 700 | -40 |
| 2007-09-15 | @ CLE | 147 | L 0-6 | 63-83 | 4 | 32,113 | Zack Greinke | Fausto Carmona | Fausto Carmona | Zack Greinke | | 660 | 706 | -46 |
| 2007-09-16 | @ CLE | 148 | W 4-3 | 64-83 | 4 | 30,112 | Billy Buckner | Aaron Laffey | Billy Buckner | Aaron Laffey | Joakim Soria | 664 | 709 | -45 |
| 2007-09-17 | vs CHA | 149 | L 3-11 | 64-84 | 5 | 14,421 | Kyle Davies | Javier Vazquez | Javier Vazquez | Kyle Davies | | 667 | 720 | -53 |
| 2007-09-18 | vs CHA | 150 | W 3-2 | 65-84 | 4 | 15,015 | Gil Meche | Gavin Floyd | Gil Meche | Gavin Floyd | Joakim Soria | 670 | 722 | -52 |
| 2007-09-19 | vs CHA | 151 | L 0-7 | 65-85 | 5 | 11,857 | Brian Bannister | Jose Contreras | Jose Contreras | Brian Bannister | | 670 | 729 | -59 |
| 2007-09-20 | vs CHA | 152 | W 3-0 | 66-85 | 4 | 10,264 | Zack Greinke | Jon Garland | Zack Greinke | Jon Garland | Joakim Soria | 673 | 729 | -56 |
| 2007-09-21 | @ DET | 153 | L 4-5 | 66-86 | 5 | 40,117 | Billy Buckner | Jair Jurrjens | Tim Byrdak | Leo Nunez | Todd Jones | 677 | 734 | -57 |
| 2007-09-22 | @ DET | 154 | W 7-4 | 67-86 | 5 | 41,792 | Kyle Davies | Kenny Rogers | Kyle Davies | Kenny Rogers | | 684 | 738 | -54 |
| 2007-09-23 | @ DET | 155 | L 2-7 | 67-87 | 5 | 40,068 | Jorge de la Rosa | Justin Verlander | Justin Verlander | Jorge de la Rosa | | 686 | 745 | -59 |
| 2007-09-24 | @ BAL | 156 | L 2-3 | 67-88 | 5 | 15,769 | Gil Meche | Daniel Cabrera | Jamie Walker | Gil Meche | Chad Bradford | 688 | 748 | -60 |
| 2007-09-25 | @ CHA | 157 | W 9-5 | 68-88 | 5 | 31,607 | Brian Bannister | Jose Contreras | Brandon Duckworth | Ehren Wassermann | | 697 | 753 | -56 |
| 2007-09-26 | @ CHA | 158 | L 0-3 | 68-89 | 5 | 32,091 | Zack Greinke | Jon Garland | Jon Garland | Zack Greinke | | 697 | 756 | -59 |
| 2007-09-27 | @ CHA | 159 | L 0-10 | 68-90 | 5 | 34,477 | Billy Buckner | Lance Broadway | Lance Broadway | Billy Buckner | | 697 | 766 | -69 |
| 2007-09-28 | vs CLE | 160 | L 3-5 | 68-91 | 5 | 29,846 | Kyle Davies | CC Sabathia | CC Sabathia | Kyle Davies | Joe Borowski | 700 | 771 | -71 |
| 2007-09-29 | vs CLE | 161 | W 4-3 | 69-91 | 5 | 24,274 | Gil Meche | Jake Westbrook | Joakim Soria | Rafael Perez | | 704 | 774 | -70 |
| 2007-09-30 | vs CLE | 162 | L 2-4 | 69-92 | 5 | 19,104 | Luke Hochevar | Aaron Laffey | Aaron Laffey | Luke Hochevar | Joe Borowski | 706 | 778 | -72 |