| 2007-04-02 | @ WAS | 1 | W 9-2 | 1-0 | 2 | 40,389 | Dontrelle Willis | John Patterson | Dontrelle Willis | John Patterson | | 9 | 2 | 7 |
| 2007-04-03 | @ WAS | 2 | W 9-3 | 2-0 | 2 | 20,894 | Scott Olsen | Shawn Hill | Scott Olsen | Shawn Hill | | 18 | 5 | 13 |
| 2007-04-04 | @ WAS | 3 | L 6-7 | 2-1 | 3 | 18,835 | Anibal Sanchez | Matt Chico | Jon Rauch | Jorge Julio | | 24 | 12 | 12 |
| 2007-04-06 | vs PHI | 4 | L 2-8 | 2-2 | 3 | 40,397 | Sergio Mitre | Jamie Moyer | Jamie Moyer | Sergio Mitre | | 26 | 20 | 6 |
| 2007-04-07 | vs PHI | 5 | W 8-5 | 3-2 | 3 | 32,419 | Dontrelle Willis | Brett Myers | Dontrelle Willis | Brett Myers | | 34 | 25 | 9 |
| 2007-04-08 | vs PHI | 6 | W 6-4 | 4-2 | 2 | 16,308 | Scott Olsen | Zack Segovia | Scott Olsen | Zack Segovia | Lee Gardner | 40 | 29 | 11 |
| 2007-04-09 | vs MIL | 7 | W 5-3 | 5-2 | 2 | 11,157 | Anibal Sanchez | Jeff Suppan | Anibal Sanchez | Jeff Suppan | Henry Owens | 45 | 32 | 13 |
| 2007-04-10 | vs MIL | 8 | L 2-3 | 5-3 | 3 | 10,883 | Rick Vanden Hurk | Claudio Vargas | Elmer Dessens | Renyel Pinto | Francisco Cordero | 47 | 35 | 12 |
| 2007-04-11 | vs MIL | 9 | L 2-5 | 5-4 | 3 | 11,379 | Sergio Mitre | David Bush | David Bush | Sergio Mitre | Francisco Cordero | 49 | 40 | 9 |
| 2007-04-13 | @ ATL | 10 | W 11-4 | 6-4 | 3 | 33,212 | Dontrelle Willis | Mark Redman | Dontrelle Willis | Mark Redman | | 60 | 44 | 16 |
| 2007-04-15 | @ ATL | 11 | L 4-8 | 6-5 | 3 | 25,189 | Scott Olsen | Tim Hudson | Tim Hudson | Scott Olsen | | 64 | 52 | 12 |
| 2007-04-16 | @ HOU | 12 | L 3-4 | 6-6 | 3 | 30,665 | Anibal Sanchez | Wandy Rodriguez | Chad Qualls | Kevin Gregg | | 67 | 56 | 11 |
| 2007-04-17 | @ HOU | 13 | L 1-6 | 6-7 | 3 | 38,106 | Sergio Mitre | Roy Oswalt | Roy Oswalt | Jorge Julio | | 68 | 62 | 6 |
| 2007-04-18 | vs NYN | 14 | L 2-9 | 6-8 | 3 | 17,219 | Dontrelle Willis | John Maine | John Maine | Dontrelle Willis | | 70 | 71 | -1 |
| 2007-04-19 | vs NYN | 15 | L 3-11 | 6-9 | 3 | 18,115 | Rick Vanden Hurk | Orlando Hernandez | Orlando Hernandez | Rick Vanden Hurk | | 73 | 82 | -9 |
| 2007-04-20 | vs WAS | 16 | L 5-6 | 6-10 | 3 | 16,469 | Scott Olsen | Shawn Hill | Jesus Colome | Lee Gardner | Saul Rivera | 78 | 88 | -10 |
| 2007-04-21 | vs WAS | 17 | W 9-3 | 7-10 | 3 | 24,107 | Anibal Sanchez | Matt Chico | Anibal Sanchez | Matt Chico | | 87 | 91 | -4 |
| 2007-04-22 | vs WAS | 18 | W 12-6 | 8-10 | 3 | 18,443 | Wes Obermueller | Jerome Williams | Wes Obermueller | Jerome Williams | Kevin Gregg | 99 | 97 | 2 |
| 2007-04-23 | vs ATL | 19 | W 8-7 | 9-10 | 3 | 13,227 | Dontrelle Willis | Kyle Davies | Dontrelle Willis | Kyle Davies | Renyel Pinto | 107 | 104 | 3 |
| 2007-04-24 | vs ATL | 20 | L 6-11 | 9-11 | 3 | 11,507 | Rick Vanden Hurk | Mark Redman | Peter Moylan | Matt Lindstrom | | 113 | 115 | -2 |
| 2007-04-25 | vs ATL | 21 | W 4-3 | 10-11 | 3 | 13,310 | Scott Olsen | Tim Hudson | Henry Owens | Bob Wickman | | 117 | 118 | -1 |
| 2007-04-27 | @ PHI | 22 | L 5-6 | 10-12 | 3 | 32,331 | Anibal Sanchez | Freddy Garcia | Tom Gordon | Randy Messenger | | 122 | 124 | -2 |
| 2007-04-28 | @ PHI | 23 | W 11-5 | 11-12 | 3 | 36,914 | Dontrelle Willis | Adam Eaton | Dontrelle Willis | Adam Eaton | | 133 | 129 | 4 |
| 2007-04-29 | @ PHI | 24 | L 1-6 | 11-13 | 3 | 45,107 | Wes Obermueller | Jamie Moyer | Jamie Moyer | Wes Obermueller | | 134 | 135 | -1 |
| 2007-04-30 | @ NYN | 25 | W 9-6 | 12-13 | 3 | 39,383 | Scott Olsen | Chan Ho Park | Scott Olsen | Chan Ho Park | Henry Owens | 143 | 141 | 2 |
| 2007-05-01 | @ NYN | 26 | W 5-2 | 13-13 | 3 | 48,458 | Ricky Nolasco | Mike Pelfrey | Ricky Nolasco | Mike Pelfrey | Henry Owens | 148 | 143 | 5 |
| 2007-05-02 | @ NYN | 27 | L 3-6 | 13-14 | 3 | 25,236 | Anibal Sanchez | Oliver Perez | Oliver Perez | Anibal Sanchez | Billy Wagner | 151 | 149 | 2 |
| 2007-05-04 | vs SDN | 28 | W 5-4 | 14-14 | 3 | 24,691 | Dontrelle Willis | Greg Maddux | Taylor Tankersley | Scott Linebrink | Henry Owens | 156 | 153 | 3 |
| 2007-05-05 | vs SDN | 29 | L 6-7 | 14-15 | 3 | 21,381 | Sergio Mitre | David Wells | Justin Hampson | Lee Gardner | Trevor Hoffman | 162 | 160 | 2 |
| 2007-05-06 | vs SDN | 30 | L 1-3 | 14-16 | 3 | 15,310 | Scott Olsen | Jake Peavy | Jake Peavy | Scott Olsen | Trevor Hoffman | 163 | 163 | 0 |
| 2007-05-07 | vs LAN | 31 | L 1-6 | 14-17 | 3 | 12,252 | Ricky Nolasco | Brad Penny | Brad Penny | Ricky Nolasco | | 164 | 169 | -5 |
| 2007-05-08 | vs LAN | 32 | W 6-5 | 15-17 | 3 | 11,124 | Wes Obermueller | Mark Hendrickson | Henry Owens | Jonathan Broxton | | 170 | 174 | -4 |
| 2007-05-09 | vs LAN | 33 | L 3-5 | 15-18 | 3 | 12,213 | Dontrelle Willis | Brett Tomko | Brett Tomko | Dontrelle Willis | Takashi Saito | 173 | 179 | -6 |
| 2007-05-10 | vs LAN | 34 | W 3-0 | 16-18 | 3 | 20,345 | Sergio Mitre | Derek Lowe | Taylor Tankersley | Derek Lowe | | 176 | 179 | -3 |
| 2007-05-11 | @ WAS | 35 | L 0-6 | 16-19 | 3 | 23,006 | Scott Olsen | Shawn Hill | Shawn Hill | Scott Olsen | | 176 | 185 | -9 |
| 2007-05-12 | @ WAS | 36 | L 3-7 | 16-20 | 4 | 19,278 | Ricky Nolasco | Matt Chico | Jon Rauch | Taylor Tankersley | | 179 | 192 | -13 |
| 2007-05-13 | @ WAS | 37 | L 4-6 | 16-21 | 4 | 20,486 | Wes Obermueller | Jason Simontacchi | Jason Simontacchi | Wes Obermueller | Jon Rauch | 183 | 198 | -15 |
| 2007-05-14 | @ PIT | 38 | L 0-7 | 16-22 | 4 | 12,958 | Dontrelle Willis | Tom Gorzelanny | Tom Gorzelanny | Dontrelle Willis | | 183 | 205 | -22 |
| 2007-05-15 | @ PIT | 39 | W 9-3 | 17-22 | 4 | 12,769 | Sergio Mitre | Paul Maholm | Sergio Mitre | Paul Maholm | | 192 | 208 | -16 |
| 2007-05-16 | @ PIT | 40 | W 4-3 | 18-22 | 4 | 15,086 | Scott Olsen | Zach Duke | Taylor Tankersley | Matt Capps | Kevin Gregg | 196 | 211 | -15 |
| 2007-05-17 | @ PIT | 41 | L 2-7 | 18-23 | 4 | 9,582 | Ricky Nolasco | Tony Armas | Shawn Chacon | Ricky Nolasco | | 198 | 218 | -20 |
| 2007-05-18 | @ TBA | 42 | W 8-4 | 19-23 | 4 | 13,003 | Byung-Hyun Kim | Edwin Jackson | Byung-Hyun Kim | Edwin Jackson | | 206 | 222 | -16 |
| 2007-05-19 | @ TBA | 43 | W 7-2 | 20-23 | 4 | 19,566 | Dontrelle Willis | Jae Weong Seo | Dontrelle Willis | Jae Weong Seo | | 213 | 224 | -11 |
| 2007-05-20 | @ TBA | 44 | W 4-3 | 21-23 | 4 | 23,554 | Sergio Mitre | James Shields | Sergio Mitre | Shawn Camp | Kevin Gregg | 217 | 227 | -10 |
| 2007-05-22 | vs PHI | 45 | W 5-3 | 22-23 | 3 | 11,162 | Scott Olsen | Cole Hamels | Scott Olsen | Cole Hamels | Kevin Gregg | 222 | 230 | -8 |
| 2007-05-23 | vs PHI | 46 | L 7-8 | 22-24 | 4 | 11,575 | Byung-Hyun Kim | Freddy Garcia | Clay Condrey | Kevin Gregg | | 229 | 238 | -9 |
| 2007-05-24 | vs PHI | 47 | W 5-4 | 23-24 | 3 | 11,811 | Dontrelle Willis | Jon Lieber | Lee Gardner | Francisco Rosario | | 234 | 242 | -8 |
| 2007-05-25 | vs NYN | 48 | L 2-6 | 23-25 | 4 | 24,278 | Sergio Mitre | Orlando Hernandez | Aaron Heilman | Renyel Pinto | | 236 | 248 | -12 |
| 2007-05-26 | vs NYN | 49 | L 2-7 | 23-26 | 4 | 34,505 | Wes Obermueller | John Maine | John Maine | Wes Obermueller | | 238 | 255 | -17 |
| 2007-05-27 | vs NYN | 50 | L 4-6 | 23-27 | 4 | 23,622 | Scott Olsen | Jorge Sosa | Jorge Sosa | Scott Olsen | Billy Wagner | 242 | 261 | -19 |
| 2007-05-28 | @ CHN | 51 | W 5-3 | 24-27 | 4 | 41,630 | Byung-Hyun Kim | Sean Marshall | Byung-Hyun Kim | Sean Marshall | Kevin Gregg | 247 | 264 | -17 |
| 2007-05-29 | @ CHN | 52 | W 9-4 | 25-27 | 4 | 39,788 | Dontrelle Willis | Jason Marquis | Dontrelle Willis | Jason Marquis | Kevin Gregg | 256 | 268 | -12 |
| 2007-05-30 | @ CHN | 53 | W 9-0 | 26-27 | 3 | 39,699 | Sergio Mitre | Ted Lilly | Randy Messenger | Ted Lilly | | 265 | 268 | -3 |
| 2007-05-31 | @ MIL | 54 | L 3-4 | 26-28 | 4 | 17,704 | Wes Obermueller | Claudio Vargas | Carlos Villanueva | Matt Lindstrom | Francisco Cordero | 268 | 272 | -4 |
| 2007-06-01 | @ MIL | 55 | L 5-8 | 26-29 | 4 | 30,852 | Scott Olsen | Jeff Suppan | Jeff Suppan | Scott Olsen | Francisco Cordero | 273 | 280 | -7 |
| 2007-06-02 | @ MIL | 56 | W 5-2 | 27-29 | 4 | 42,250 | Byung-Hyun Kim | Chris Capuano | Matt Lindstrom | Jose Capellan | Kevin Gregg | 278 | 282 | -4 |
| 2007-06-03 | @ MIL | 57 | L 0-3 | 27-30 | 4 | 43,172 | Dontrelle Willis | Ben Sheets | Ben Sheets | Dontrelle Willis | Francisco Cordero | 278 | 285 | -7 |
| 2007-06-04 | @ ATL | 58 | W 6-4 | 28-30 | 4 | 22,175 | Wes Obermueller | Tim Hudson | Wes Obermueller | Tim Hudson | Kevin Gregg | 284 | 289 | -5 |
| 2007-06-05 | @ ATL | 59 | L 1-3 | 29-30 | 4 | 20,863 | Sergio Mitre | Buddy Carlyle | Buddy Carlyle | Renyel Pinto | Bob Wickman | 285 | 292 | -7 |
| 2007-06-05 | @ ATL | 60 | W 5-1 | 29-30 | 4 | 27,072 | Rick Vanden Hurk | John Smoltz | Rick Vanden Hurk | John Smoltz | | 290 | 293 | -3 |
| 2007-06-06 | @ ATL | 61 | W 7-4 | 29-31 | 4 | 28,026 | Scott Olsen | Kyle Davies | Justin Miller | Kyle Davies | Kevin Gregg | 297 | 297 | 0 |
| 2007-06-08 | vs TBA | 62 | W 14-8 | 30-31 | 4 | 13,520 | Byung-Hyun Kim | J.P. Howell | Justin Miller | Brian Stokes | | 311 | 305 | 6 |
| 2007-06-09 | vs TBA | 63 | L 2-7 | 30-32 | 4 | 20,189 | Dontrelle Willis | James Shields | James Shields | Dontrelle Willis | | 313 | 312 | 1 |
| 2007-06-10 | vs TBA | 64 | L 4-9 | 30-33 | 4 | 11,525 | Rick Vanden Hurk | Andy Sonnanstine | Andy Sonnanstine | Rick Vanden Hurk | | 317 | 321 | -4 |
| 2007-06-12 | vs CLE | 65 | W 3-0 | 31-33 | 4 | 15,144 | Scott Olsen | Fausto Carmona | Scott Olsen | Fausto Carmona | Kevin Gregg | 320 | 321 | -1 |
| 2007-06-13 | vs CLE | 66 | L 3-7 | 31-34 | 4 | 13,805 | Byung-Hyun Kim | Cliff Lee | Cliff Lee | Byung-Hyun Kim | | 323 | 328 | -5 |
| 2007-06-14 | vs CLE | 67 | L 2-3 | 31-35 | 4 | 23,811 | Dontrelle Willis | Jason Stanford | Jason Stanford | Dontrelle Willis | Joe Borowski | 325 | 331 | -6 |
| 2007-06-15 | @ KCA | 68 | L 2-6 | 31-36 | 4 | 28,015 | Sergio Mitre | Gil Meche | Gil Meche | Sergio Mitre | Octavio Dotel | 327 | 337 | -10 |
| 2007-06-16 | @ KCA | 69 | W 9-8 | 32-36 | 4 | 24,323 | Rick Vanden Hurk | Jorge de la Rosa | Rick Vanden Hurk | Jorge de la Rosa | Kevin Gregg | 336 | 345 | -9 |
| 2007-06-17 | @ KCA | 70 | L 4-5 | 32-37 | 4 | 19,433 | Scott Olsen | Brian Bannister | Brian Bannister | Scott Olsen | Octavio Dotel | 340 | 350 | -10 |
| 2007-06-18 | @ CHA | 71 | L 6-10 | 32-38 | 4 | 36,132 | Josh Johnson | Jose Contreras | Jose Contreras | Josh Johnson | Bobby Jenks | 346 | 360 | -14 |
| 2007-06-19 | @ CHA | 72 | W 7-5 | 33-38 | 4 | 35,327 | Dontrelle Willis | John Danks | Armando Benitez | Matt Thornton | Kevin Gregg | 353 | 365 | -12 |
| 2007-06-20 | @ CHA | 73 | W 5-4 | 34-38 | 4 | 32,007 | Sergio Mitre | Jon Garland | Taylor Tankersley | Jon Garland | Kevin Gregg | 358 | 369 | -11 |
| 2007-06-22 | vs MIN | 74 | W 5-4 | 35-38 | 4 | 15,271 | Scott Olsen | Boof Bonser | Armando Benitez | Juan Rincon | Kevin Gregg | 363 | 373 | -10 |
| 2007-06-23 | vs MIN | 75 | L 1-11 | 35-39 | 4 | 21,368 | Josh Johnson | Carlos Silva | Carlos Silva | Josh Johnson | | 364 | 384 | -20 |
| 2007-06-24 | vs MIN | 76 | L 4-7 | 35-40 | 4 | 15,035 | Byung-Hyun Kim | Johan Santana | Johan Santana | Byung-Hyun Kim | | 368 | 391 | -23 |
| 2007-06-26 | vs PIT | 77 | L 2-3 | 35-41 | 4 | 11,044 | Dontrelle Willis | Paul Maholm | Paul Maholm | Dontrelle Willis | Matt Capps | 370 | 394 | -24 |
| 2007-06-27 | vs PIT | 78 | L 5-7 | 35-42 | 4 | 11,222 | Sergio Mitre | John Van Benschoten | Shawn Chacon | Kevin Gregg | Matt Capps | 375 | 401 | -26 |
| 2007-06-28 | vs PIT | 79 | W 9-7 | 36-42 | 4 | 31,628 | Scott Olsen | Zach Duke | Scott Olsen | Zach Duke | Kevin Gregg | 384 | 408 | -24 |
| 2007-06-29 | vs ATL | 80 | L 3-12 | 36-43 | 4 | 17,181 | Josh Johnson | Chuck James | Chuck James | Josh Johnson | | 387 | 420 | -33 |
| 2007-06-30 | vs ATL | 81 | L 5-6 | 36-44 | 4 | 24,229 | Byung-Hyun Kim | Tim Hudson | Tim Hudson | Armando Benitez | Tyler Yates | 392 | 426 | -34 |
| 2007-07-01 | vs ATL | 82 | W 6-5 | 37-44 | 4 | 14,311 | Dontrelle Willis | Buddy Carlyle | Lee Gardner | Rafael Soriano | | 398 | 431 | -33 |
| 2007-07-02 | @ SDN | 83 | L 1-3 | 37-45 | 4 | 25,857 | Sergio Mitre | David Wells | David Wells | Sergio Mitre | Trevor Hoffman | 399 | 434 | -35 |
| 2007-07-03 | @ SDN | 84 | W 6-4 | 38-45 | 4 | 34,488 | Scott Olsen | Greg Maddux | Justin Miller | Greg Maddux | Kevin Gregg | 405 | 438 | -33 |
| 2007-07-04 | @ SDN | 85 | L 0-1 | 38-46 | 4 | 27,941 | Josh Johnson | Chris Young | Heath Bell | Matt Lindstrom | | 405 | 439 | -34 |
| 2007-07-05 | @ SDN | 86 | W 3-2 | 39-46 | 4 | 32,496 | Byung-Hyun Kim | Jake Peavy | Byung-Hyun Kim | Jake Peavy | Kevin Gregg | 408 | 441 | -33 |
| 2007-07-06 | @ LAN | 87 | W 6-5 | 40-46 | 4 | 51,050 | Dontrelle Willis | Chad Billingsley | Renyel Pinto | Brett Tomko | Kevin Gregg | 414 | 446 | -32 |
| 2007-07-07 | @ LAN | 88 | W 7-2 | 41-46 | 4 | 46,177 | Sergio Mitre | Derek Lowe | Sergio Mitre | Derek Lowe | | 421 | 448 | -27 |
| 2007-07-08 | @ LAN | 89 | L 3-9 | 41-47 | 4 | 44,021 | Scott Olsen | Mark Hendrickson | Mark Hendrickson | Scott Olsen | | 424 | 457 | -33 |
| 2007-07-13 | vs WAS | 90 | L 10-14 | 41-48 | 4 | 11,438 | Dontrelle Willis | Jason Bergmann | Saul Rivera | Dontrelle Willis | | 434 | 471 | -37 |
| 2007-07-14 | vs WAS | 91 | W 5-2 | 42-48 | 4 | 21,012 | Sergio Mitre | Matt Chico | Sergio Mitre | Matt Chico | Kevin Gregg | 439 | 473 | -34 |
| 2007-07-15 | vs WAS | 92 | W 5-3 | 43-48 | 4 | 12,119 | Scott Olsen | Jason Simontacchi | Scott Olsen | Jason Simontacchi | Kevin Gregg | 444 | 476 | -32 |
| 2007-07-16 | vs SLN | 93 | L 3-5 | 43-49 | 4 | 13,827 | Byung-Hyun Kim | Braden Looper | Braden Looper | Byung-Hyun Kim | Jason Isringhausen | 447 | 481 | -34 |
| 2007-07-17 | vs SLN | 94 | W 4-0 | 44-49 | 4 | 12,475 | Rick Vanden Hurk | Brad Thompson | Rick Vanden Hurk | Brad Thompson | | 451 | 481 | -30 |
| 2007-07-18 | vs SLN | 95 | L 0-6 | 44-50 | 4 | 12,819 | Dontrelle Willis | Kip Wells | Kip Wells | Dontrelle Willis | | 451 | 487 | -36 |
| 2007-07-19 | vs CIN | 96 | L 5-7 | 44-51 | 4 | 10,344 | Sergio Mitre | Matt Belisle | Todd Coffey | Armando Benitez | David Weathers | 456 | 494 | -38 |
| 2007-07-20 | vs CIN | 97 | W 10-2 | 45-51 | 4 | 15,313 | Scott Olsen | Kyle Lohse | Scott Olsen | Kyle Lohse | | 466 | 496 | -30 |
| 2007-07-21 | vs CIN | 98 | W 11-1 | 46-51 | 4 | 21,823 | Byung-Hyun Kim | Bobby Livingston | Byung-Hyun Kim | Bobby Livingston | | 477 | 497 | -20 |
| 2007-07-22 | vs CIN | 99 | W 9-3 | 47-51 | 4 | 14,123 | Rick Vanden Hurk | Bronson Arroyo | Renyel Pinto | Bronson Arroyo | | 486 | 500 | -14 |
| 2007-07-23 | @ ARI | 100 | L 3-4 | 47-52 | 4 | 19,620 | Dontrelle Willis | Doug Davis | Doug Davis | Dontrelle Willis | Jose Valverde | 489 | 504 | -15 |
| 2007-07-24 | @ ARI | 101 | L 3-9 | 47-53 | 4 | 21,035 | Sergio Mitre | Livan Hernandez | Livan Hernandez | Sergio Mitre | | 492 | 513 | -21 |
| 2007-07-25 | @ ARI | 102 | L 0-7 | 47-54 | 4 | 20,154 | Scott Olsen | Brandon Webb | Brandon Webb | Scott Olsen | | 492 | 520 | -28 |
| 2007-07-26 | @ ARI | 103 | L 4-7 | 47-55 | 4 | 18,721 | Byung-Hyun Kim | Micah Owings | Tony Pena | Armando Benitez | | 496 | 527 | -31 |
| 2007-07-27 | @ SFN | 104 | L 10-12 | 47-56 | 4 | 42,831 | Rick Vanden Hurk | Barry Zito | Vinnie Chulk | Renyel Pinto | | 506 | 539 | -33 |
| 2007-07-28 | @ SFN | 105 | L 3-4 | 47-57 | 4 | 43,001 | Dontrelle Willis | Matt Cain | Jack Taschner | Kevin Gregg | | 509 | 543 | -34 |
| 2007-07-29 | @ SFN | 106 | W 8-5 | 48-57 | 4 | 42,965 | Sergio Mitre | Matt Morris | Sergio Mitre | Matt Morris | Kevin Gregg | 517 | 548 | -31 |
| 2007-07-31 | vs COL | 107 | L 3-6 | 48-58 | 4 | 11,534 | Scott Olsen | Aaron Cook | Aaron Cook | Scott Olsen | Manuel Corpas | 520 | 554 | -34 |
| 2007-08-01 | vs COL | 108 | W 4-3 | 49-58 | 4 | 11,556 | Byung-Hyun Kim | Josh Fogg | Byung-Hyun Kim | Josh Fogg | Kevin Gregg | 524 | 557 | -33 |
| 2007-08-02 | vs COL | 109 | L 3-4 | 49-59 | 4 | 11,927 | Rick Vanden Hurk | Jason Hirsh | LaTroy Hawkins | Armando Benitez | Manuel Corpas | 527 | 561 | -34 |
| 2007-08-03 | vs HOU | 110 | L 2-8 | 49-60 | 4 | 15,226 | Dontrelle Willis | Roy Oswalt | Roy Oswalt | Dontrelle Willis | | 529 | 569 | -40 |
| 2007-08-04 | vs HOU | 111 | W 6-5 | 50-60 | 4 | 22,112 | Sergio Mitre | Jason Jennings | Lee Gardner | Steve Randolph | | 535 | 574 | -39 |
| 2007-08-05 | vs HOU | 112 | W 6-5 | 51-60 | 4 | 14,622 | Scott Olsen | Matt Albers | Scott Olsen | Matt Albers | Kevin Gregg | 541 | 579 | -38 |
| 2007-08-07 | @ PHI | 113 | L 1-11 | 51-61 | 4 | 32,791 | Rick Vanden Hurk | Jamie Moyer | Jamie Moyer | Rick Vanden Hurk | J.D. Durbin | 542 | 590 | -48 |
| 2007-08-08 | @ PHI | 114 | L 4-6 | 51-62 | 4 | 34,139 | Dontrelle Willis | Kyle Lohse | Kyle Lohse | Dontrelle Willis | Brett Myers | 546 | 596 | -50 |
| 2007-08-09 | @ PHI | 115 | W 4-2 | 52-62 | 4 | 37,009 | Sergio Mitre | Kyle Kendrick | Taylor Tankersley | Brett Myers | Kevin Gregg | 550 | 598 | -48 |
| 2007-08-10 | @ NYN | 116 | W 4-3 | 53-62 | 4 | 48,516 | Daniel Barone | Brian Lawrence | Matt Lindstrom | Billy Wagner | Kevin Gregg | 554 | 601 | -47 |
| 2007-08-11 | @ NYN | 117 | W 7-5 | 54-62 | 4 | 50,773 | Scott Olsen | Tom Glavine | Justin Miller | Aaron Heilman | Kevin Gregg | 561 | 606 | -45 |
| 2007-08-12 | @ NYN | 118 | L 4-10 | 54-63 | 4 | 51,023 | Rick Vanden Hurk | Oliver Perez | Jorge Sosa | Lee Gardner | | 565 | 616 | -51 |
| 2007-08-14 | vs ARI | 119 | W 14-5 | 55-63 | 4 | 10,610 | Dontrelle Willis | Byung-Hyun Kim | Dontrelle Willis | Byung-Hyun Kim | | 579 | 621 | -42 |
| 2007-08-15 | vs ARI | 120 | L 6-9 | 55-64 | 4 | 11,472 | Sergio Mitre | Doug Davis | Doug Davis | Sergio Mitre | Jose Valverde | 585 | 630 | -45 |
| 2007-08-16 | vs ARI | 121 | L 4-5 | 55-65 | 4 | 11,516 | Daniel Barone | Livan Hernandez | Livan Hernandez | Daniel Barone | Jose Valverde | 589 | 635 | -46 |
| 2007-08-17 | vs SFN | 122 | L 0-3 | 55-66 | 4 | 25,079 | Scott Olsen | Barry Zito | Barry Zito | Scott Olsen | Brad Hennessey | 589 | 638 | -49 |
| 2007-08-18 | vs SFN | 123 | L 3-4 | 55-67 | 4 | 42,817 | Rick Vanden Hurk | Matt Cain | Matt Cain | Rick Vanden Hurk | Brad Hennessey | 592 | 642 | -50 |
| 2007-08-19 | vs SFN | 124 | L 5-6 | 55-68 | 4 | 15,351 | Dontrelle Willis | Noah Lowry | Vinnie Chulk | Lee Gardner | Brad Hennessey | 597 | 648 | -51 |
| 2007-08-20 | vs SFN | 125 | L 7-8 | 55-69 | 4 | 10,907 | Sergio Mitre | Russ Ortiz | Jack Taschner | Ross Wolf | Brian Wilson | 604 | 656 | -52 |
| 2007-08-21 | @ SLN | 126 | L 2-5 | 55-70 | 5 | 42,059 | Daniel Barone | Adam Wainwright | Troy Percival | Armando Benitez | Jason Isringhausen | 606 | 661 | -55 |
| 2007-08-22 | @ SLN | 127 | L 4-6 | 55-71 | 5 | 42,147 | Scott Olsen | Braden Looper | Russ Springer | Scott Olsen | Jason Isringhausen | 610 | 667 | -57 |
| 2007-08-23 | @ SLN | 128 | W 11-3 | 56-71 | 5 | 42,123 | Rick Vanden Hurk | Anthony Reyes | Rick Vanden Hurk | Anthony Reyes | | 621 | 670 | -49 |
| 2007-08-24 | @ CIN | 129 | L 3-5 | 56-72 | 5 | 25,773 | Dontrelle Willis | Aaron Harang | Aaron Harang | Dontrelle Willis | David Weathers | 624 | 675 | -51 |
| 2007-08-25 | @ CIN | 130 | L 7-11 | 56-73 | 5 | 32,288 | Sergio Mitre | Matt Belisle | Matt Belisle | Sergio Mitre | | 631 | 686 | -55 |
| 2007-08-26 | @ CIN | 131 | L 3-9 | 56-74 | 5 | 23,122 | Daniel Barone | Tom Shearn | Tom Shearn | Daniel Barone | | 634 | 695 | -61 |
| 2007-08-27 | vs ATL | 132 | L 2-13 | 56-75 | 5 | 11,716 | Scott Olsen | Lance Cormier | Lance Cormier | Scott Olsen | | 636 | 708 | -72 |
| 2007-08-28 | vs ATL | 133 | W 4-3 | 57-75 | 4 | 11,539 | Rick Vanden Hurk | John Smoltz | Byung-Hyun Kim | Oscar Villarreal | | 640 | 711 | -71 |
| 2007-08-29 | vs ATL | 134 | L 4-7 | 57-76 | 4 | 12,633 | Dontrelle Willis | Buddy Carlyle | Buddy Carlyle | Dontrelle Willis | Rafael Soriano | 644 | 718 | -74 |
| 2007-08-31 | vs PHI | 135 | L 2-9 | 57-77 | 4 | 15,231 | Sergio Mitre | Kyle Kendrick | Kyle Kendrick | Sergio Mitre | | 646 | 727 | -81 |
| 2007-09-01 | vs PHI | 136 | W 12-6 | 58-77 | 4 | 24,651 | Byung-Hyun Kim | J.D. Durbin | Byung-Hyun Kim | J.D. Durbin | Kevin Gregg | 658 | 733 | -75 |
| 2007-09-02 | vs PHI | 137 | W 7-6 | 59-77 | 4 | 12,334 | Scott Olsen | Adam Eaton | Justin Miller | Kane Davis | Kevin Gregg | 665 | 739 | -74 |
| 2007-09-03 | @ WAS | 138 | L 3-6 | 59-78 | 5 | 27,592 | Rick Vanden Hurk | Jason Bergmann | Jason Bergmann | Rick Vanden Hurk | Chad Cordero | 668 | 745 | -77 |
| 2007-09-04 | @ WAS | 139 | L 3-4 | 59-79 | 5 | 15,611 | Dontrelle Willis | Shawn Hill | Chris Schroder | Kevin Gregg | | 671 | 749 | -78 |
| 2007-09-05 | @ WAS | 140 | L 4-6 | 59-80 | 5 | 19,222 | Sergio Mitre | Tim Redding | Luis Ayala | Matt Lindstrom | Chad Cordero | 675 | 755 | -80 |
| 2007-09-07 | @ PHI | 141 | W 6-3 | 60-80 | 5 | 38,696 | Byung-Hyun Kim | J.D. Durbin | Byung-Hyun Kim | J.D. Durbin | Kevin Gregg | 681 | 758 | -77 |
| 2007-09-08 | @ PHI | 142 | L 1-9 | 60-81 | 5 | 38,559 | Rick Vanden Hurk | John Ennis | Clay Condrey | Rick Vanden Hurk | | 682 | 767 | -85 |
| 2007-09-09 | @ PHI | 143 | L 5-8 | 60-82 | 5 | 32,574 | Dontrelle Willis | Jamie Moyer | Jamie Moyer | Dontrelle Willis | Brett Myers | 687 | 775 | -88 |
| 2007-09-10 | vs WAS | 144 | L 4-5 | 60-83 | 5 | 12,345 | Scott Olsen | Shawn Hill | Shawn Hill | Scott Olsen | Chad Cordero | 691 | 780 | -89 |
| 2007-09-11 | vs WAS | 145 | W 13-8 | 61-83 | 5 | 11,078 | Chris Seddon | Michael Bacsik | Matt Lindstrom | Chris Schroder | | 704 | 788 | -84 |
| 2007-09-12 | vs WAS | 146 | W 5-4 | 62-83 | 5 | 10,121 | Byung-Hyun Kim | Joel Hanrahan | Daniel Barone | Saul Rivera | | 709 | 792 | -83 |
| 2007-09-14 | @ COL | 147 | W 7-6 | 63-83 | 5 | 22,400 | Dontrelle Willis | Josh Fogg | Dontrelle Willis | Matt Herges | Kevin Gregg | 716 | 798 | -82 |
| 2007-09-15 | @ COL | 148 | W 10-2 | 64-83 | 5 | 26,079 | Sergio Mitre | Ubaldo Jimenez | Logan Kensing | Ubaldo Jimenez | | 726 | 800 | -74 |
| 2007-09-16 | @ COL | 149 | L 0-13 | 64-84 | 5 | 19,161 | Scott Olsen | Franklin Morales | Franklin Morales | Scott Olsen | | 726 | 813 | -87 |
| 2007-09-17 | @ ATL | 150 | L 6-11 | 64-85 | 5 | 20,957 | Byung-Hyun Kim | John Smoltz | John Smoltz | Byung-Hyun Kim | | 732 | 824 | -92 |
| 2007-09-18 | @ ATL | 151 | L 3-4 | 64-86 | 5 | 22,076 | Chris Seddon | Jo-Jo Reyes | Jo-Jo Reyes | Chris Seddon | Rafael Soriano | 735 | 828 | -93 |
| 2007-09-19 | @ ATL | 152 | L 1-5 | 64-87 | 5 | 24,449 | Daniel Barone | Chuck James | Chuck James | Daniel Barone | | 736 | 833 | -97 |
| 2007-09-20 | vs NYN | 153 | W 8-7 | 65-87 | 5 | 15,132 | Dontrelle Willis | Tom Glavine | Taylor Tankersley | Jorge Sosa | | 744 | 840 | -96 |
| 2007-09-21 | vs NYN | 154 | L 6-9 | 65-88 | 5 | 25,666 | Scott Olsen | Pedro Martinez | Pedro Martinez | Scott Olsen | Scott Schoeneweis | 750 | 849 | -99 |
| 2007-09-22 | vs NYN | 155 | L 2-7 | 65-89 | 5 | 22,517 | Byung-Hyun Kim | Oliver Perez | Oliver Perez | Byung-Hyun Kim | | 752 | 856 | -104 |
| 2007-09-23 | vs NYN | 156 | L 6-7 | 65-90 | 5 | 17,130 | Chris Seddon | John Maine | Joe Smith | Harvey Garcia | Scott Schoeneweis | 758 | 863 | -105 |
| 2007-09-25 | vs CHN | 157 | W 4-2 | 66-90 | 5 | 16,044 | Dontrelle Willis | Ted Lilly | Dontrelle Willis | Ted Lilly | Taylor Tankersley | 762 | 865 | -103 |
| 2007-09-26 | vs CHN | 158 | W 7-4 | 67-90 | 5 | 19,051 | Daniel Barone | Jason Marquis | Logan Kensing | Jason Marquis | Lee Gardner | 769 | 869 | -100 |
| 2007-09-27 | vs CHN | 159 | W 6-4 | 68-90 | 5 | 24,809 | Scott Olsen | Steve Trachsel | Scott Olsen | Steve Trachsel | Kevin Gregg | 775 | 873 | -98 |
| 2007-09-28 | @ NYN | 160 | W 7-4 | 69-90 | 5 | 55,298 | Byung-Hyun Kim | Oliver Perez | Byung-Hyun Kim | Oliver Perez | Kevin Gregg | 782 | 877 | -95 |
| 2007-09-29 | @ NYN | 161 | L 0-13 | 69-91 | 5 | 54,675 | Chris Seddon | John Maine | John Maine | Chris Seddon | | 782 | 890 | -108 |
| 2007-09-30 | @ NYN | 162 | W 8-1 | 70-91 | 5 | 54,453 | Dontrelle Willis | Tom Glavine | Logan Kensing | Tom Glavine | | 790 | 891 | -101 |