| 38 | Carlos Zambrano | - | 8 | 33 | 33 | 214.0 | 3.41 | 1.29 | 6.81 | 0.84 | 4.84 | 8.83 | 0.55 | 0.97 | 22 | 9 | 778 | .208 | 917 | 3.95 | 40.4 | 59.6 | 9.1 |
| 31 | Greg Maddux | - | 15 | 22 | 22 | 136.1 | 4.69 | 1.29 | 10.10 | 0.92 | 1.52 | 5.35 | 0.28 | 1.08 | 10 | 0 | 539 | .284 | 572 | 3.33 | 33.4 | 66.6 | 8.0 |
| 45 | Sean Marshall | - | - | 24 | 24 | 125.2 | 5.59 | 1.52 | 9.45 | 1.43 | 4.23 | 5.51 | 0.77 | 0.94 | 9 | 7 | 489 | .270 | 563 | 3.66 | 41.5 | 58.5 | 6.1 |
| 53 | Rich Hill | - | 86 | 17 | 16 | 99.1 | 4.17 | 1.23 | 7.52 | 1.45 | 3.53 | 8.15 | 0.43 | 0.50 | 8 | 2 | 365 | .227 | 417 | 3.93 | 36.5 | 63.5 | 8.5 |
| 49 | Carlos Marmol | - | - | 19 | 13 | 77.0 | 6.08 | 1.69 | 8.30 | 1.64 | 6.90 | 6.90 | 1.00 | 0.49 | 4 | 5 | 284 | .250 | 356 | 3.95 | 44.1 | 55.9 | 8.3 |
| 62 | Bob Howry | - | 55 | 84 | 0 | 76.2 | 3.17 | 1.13 | 8.22 | 0.94 | 2.00 | 8.33 | 0.24 | 0.66 | 0 | 3 | 286 | .245 | 314 | 4.15 | 35.7 | 64.3 | 10.1 |
| 44 | Roberto Novoa | - | - | 66 | 0 | 76.0 | 4.26 | 1.43 | 9.12 | 1.78 | 3.79 | 6.28 | 0.60 | 0.79 | 0 | 6 | 294 | .262 | 336 | 3.90 | 39.7 | 60.3 | 9.0 |
| 46 | Ryan Dempster | - | 37 | 74 | 0 | 75.0 | 4.80 | 1.51 | 9.24 | 0.60 | 4.32 | 8.04 | 0.54 | 1.23 | 0 | 3 | 294 | .262 | 342 | 4.00 | 39.7 | 60.3 | 10.2 |
| 33 | Glendon Rusch | - | - | 25 | 9 | 66.1 | 7.46 | 1.79 | 11.67 | 2.85 | 4.48 | 8.01 | 0.56 | 0.62 | 1 | 1 | 269 | .320 | 311 | 4.29 | 39.5 | 60.5 | 6.9 |
| 50,13 | Will Ohman | - | 68 | 78 | 0 | 65.1 | 4.13 | 1.30 | 7.03 | 0.83 | 4.68 | 10.19 | 0.46 | 0.52 | 0 | 5 | 245 | .208 | 286 | 3.91 | 38.9 | 61.1 | 12.0 |
| 47 | Scott Eyre | - | 79 | 74 | 0 | 61.1 | 3.38 | 1.48 | 8.95 | 1.61 | 4.40 | 10.71 | 0.41 | 0.81 | 0 | 0 | 230 | .265 | 266 | 4.32 | 40.2 | 59.8 | 10.8 |
| 37 | Angel Guzman | - | - | 15 | 10 | 56.0 | 7.39 | 1.88 | 10.93 | 1.45 | 5.95 | 9.64 | 0.62 | 0.53 | 1 | 6 | 221 | .308 | 272 | 4.11 | 40.4 | 59.6 | 9.7 |
| 54 | David Aardsma | - | - | 45 | 0 | 53.0 | 4.08 | 1.30 | 6.96 | 1.53 | 4.75 | 8.32 | 0.57 | 0.62 | 0 | 1 | 192 | .214 | 225 | 4.29 | 37.9 | 62.1 | 10.1 |
| 51 | Juan Mateo | - | - | 11 | 10 | 45.2 | 5.32 | 1.62 | 10.05 | 1.18 | 4.53 | 6.90 | 0.66 | 0.79 | 1 | 3 | 177 | .288 | 210 | 3.81 | 37.3 | 62.7 | 7.4 |
| 22 | Mark Prior | - | - | 9 | 9 | 43.2 | 7.21 | 1.69 | 9.48 | 1.85 | 5.77 | 7.83 | 0.74 | 0.61 | 1 | 8 | 171 | .269 | 211 | 4.03 | 43.0 | 57.0 | 5.4 |
| 43 | Mike Wuertz | - | - | 41 | 0 | 40.2 | 2.66 | 1.25 | 7.75 | 1.11 | 3.54 | 9.30 | 0.38 | 1.23 | 0 | 1 | 155 | .226 | 175 | 3.90 | 37.0 | 63.0 | 17.6 |
| 48 | Scott Williamson | - | - | 31 | 0 | 28.1 | 5.08 | 1.52 | 8.58 | 0.64 | 5.08 | 10.16 | 0.50 | 1.00 | 0 | 1 | 109 | .248 | 127 | 3.83 | 42.6 | 57.4 | 14.6 |
| 52 | Wade Miller | - | - | 5 | 5 | 21.2 | 4.57 | 1.71 | 7.89 | 1.66 | 7.48 | 8.31 | 0.90 | 0.52 | 0 | 1 | 82 | .232 | 103 | 4.14 | 46.2 | 53.8 | 9.4 |
| 34 | Kerry Wood | - | - | 4 | 4 | 19.2 | 4.12 | 1.37 | 8.69 | 2.29 | 3.66 | 5.95 | 0.62 | 0.73 | 1 | 1 | 75 | .253 | 86 | 3.73 | 34.9 | 65.1 | 7.2 |
| 55 | Les Walrond | - | - | 10 | 2 | 17.1 | 6.23 | 1.79 | 9.87 | 1.04 | 6.23 | 10.90 | 0.57 | 1.17 | 0 | 0 | 70 | .271 | 84 | 3.83 | 45.7 | 54.3 | 10.2 |
| 20 | Jae-Kuk Ryu | - | - | 10 | 1 | 15.0 | 8.40 | 1.93 | 13.80 | 4.20 | 3.60 | 10.20 | 0.35 | 0.68 | 0 | 2 | 66 | .348 | 77 | 3.60 | 40.1 | 59.9 | 12.6 |
| 48 | Ryan O'Malley | - | - | 2 | 2 | 12.2 | 2.13 | 1.34 | 7.11 | -- | 4.97 | 2.84 | 1.75 | 0.34 | 1 | 1 | 47 | .213 | 55 | 3.35 | 39.7 | 60.3 | 4.3 |
| 32,57 | Jerome Williams | - | - | 5 | 2 | 12.1 | 7.30 | 2.11 | 10.95 | 1.46 | 8.03 | 3.65 | 2.20 | 1.00 | 1 | 1 | 46 | .326 | 61 | 4.00 | 42.6 | 57.4 | 5.7 |