| 2006-04-03 | @ PHI | 1 | W 13-5 | 1-0 | 4 | 44,614 | Chris Carpenter | Jon Lieber | Chris Carpenter | Jon Lieber | | 13 | 5 | 8 |
| 2006-04-05 | @ PHI | 2 | W 4-3 | 2-0 | 2 | 20,557 | Mark Mulder | Brett Myers | Brad Thompson | Tom Gordon | Jason Isringhausen | 17 | 8 | 9 |
| 2006-04-06 | @ PHI | 3 | W 4-2 | 3-0 | 2 | 20,413 | Jason Marquis | Cory Lidle | Jason Marquis | Cory Lidle | Jason Isringhausen | 21 | 10 | 11 |
| 2006-04-07 | @ CHN | 4 | L 1-5 | 3-1 | 4 | 40,869 | Jeff Suppan | Greg Maddux | Greg Maddux | Jeff Suppan | | 22 | 15 | 7 |
| 2006-04-08 | @ CHN | 5 | L 2-3 | 3-2 | 5 | 40,182 | Chris Carpenter | Carlos Zambrano | Bob Howry | Brad Thompson | Ryan Dempster | 24 | 18 | 6 |
| 2006-04-09 | @ CHN | 6 | L 4-8 | 3-3 | 5 | 39,839 | Sidney Ponson | Sean Marshall | Scott Williamson | Jason Isringhausen | | 28 | 26 | 2 |
| 2006-04-10 | vs MIL | 7 | W 6-4 | 4-3 | 5 | 41,936 | Mark Mulder | Tomo Ohka | Mark Mulder | Tomo Ohka | Jason Isringhausen | 34 | 30 | 4 |
| 2006-04-12 | vs MIL | 8 | W 8-3 | 5-3 | 5 | 40,648 | Jason Marquis | David Bush | Jason Marquis | David Bush | | 42 | 33 | 9 |
| 2006-04-13 | vs MIL | 9 | L 3-4 | 5-4 | 5 | 40,222 | Jeff Suppan | Doug Davis | Jorge de la Rosa | Jason Isringhausen | Derrick Turnbow | 45 | 37 | 8 |
| 2006-04-14 | vs CIN | 10 | L 0-1 | 5-5 | 5 | 40,901 | Chris Carpenter | Aaron Harang | Aaron Harang | Chris Carpenter | David Weathers | 45 | 38 | 7 |
| 2006-04-15 | vs CIN | 11 | W 9-3 | 6-5 | 5 | 40,752 | Sidney Ponson | David Williams | Sidney Ponson | David Williams | | 54 | 41 | 13 |
| 2006-04-16 | vs CIN | 12 | W 8-7 | 7-5 | 5 | 40,068 | Mark Mulder | Bronson Arroyo | Braden Looper | David Weathers | | 62 | 48 | 14 |
| 2006-04-17 | @ PIT | 13 | W 2-1 | 8-5 | 4 | 15,278 | Jason Marquis | Paul Maholm | Jason Marquis | Paul Maholm | Jason Isringhausen | 64 | 49 | 15 |
| 2006-04-18 | @ PIT | 14 | L 4-12 | 8-6 | 4 | 16,682 | Jeff Suppan | Oliver Perez | Oliver Perez | Jeff Suppan | | 68 | 61 | 7 |
| 2006-04-19 | @ PIT | 15 | W 4-0 | 9-6 | 4 | 15,085 | Chris Carpenter | Victor Santos | Chris Carpenter | Victor Santos | | 72 | 61 | 11 |
| 2006-04-21 | vs CHN | 16 | W 9-3 | 10-6 | 3 | 41,379 | Mark Mulder | Jerome Williams | Mark Mulder | Jerome Williams | | 81 | 64 | 17 |
| 2006-04-22 | vs CHN | 17 | W 4-1 | 11-6 | 2 | 41,424 | Sidney Ponson | Glendon Rusch | Sidney Ponson | Glendon Rusch | Jason Isringhausen | 85 | 65 | 20 |
| 2006-04-23 | vs CHN | 18 | L 3-7 | 11-7 | 3 | 41,373 | Jason Marquis | Greg Maddux | Greg Maddux | Jason Marquis | | 88 | 72 | 16 |
| 2006-04-24 | vs PIT | 19 | W 7-2 | 12-7 | 3 | 38,953 | Chris Carpenter | Oliver Perez | Chris Carpenter | Oliver Perez | | 95 | 74 | 21 |
| 2006-04-25 | vs PIT | 20 | W 6-3 | 13-7 | 3 | 38,809 | Jeff Suppan | Victor Santos | Jeff Suppan | Victor Santos | Jason Isringhausen | 101 | 77 | 24 |
| 2006-04-26 | vs PIT | 21 | W 4-3 | 14-7 | 3 | 38,728 | Mark Mulder | Zach Duke | Jason Isringhausen | Roberto Hernandez | | 105 | 80 | 25 |
| 2006-04-27 | vs WAS | 22 | W 6-2 | 15-7 | 3 | 39,515 | Sidney Ponson | Mike O'Connor | Sidney Ponson | Mike O'Connor | | 111 | 82 | 29 |
| 2006-04-28 | vs WAS | 23 | L 3-8 | 15-8 | 3 | 40,841 | Jason Marquis | Tony Armas | Tony Armas | Jason Marquis | | 114 | 90 | 24 |
| 2006-04-29 | vs WAS | 24 | W 2-1 | 16-8 | 2 | 39,596 | Chris Carpenter | Livan Hernandez | Braden Looper | Jon Rauch | Jason Isringhausen | 116 | 91 | 25 |
| 2006-04-30 | vs WAS | 25 | W 9-2 | 17-8 | 2 | 39,383 | Jeff Suppan | Zach Day | Jeff Suppan | Zach Day | | 125 | 93 | 32 |
| 2006-05-01 | @ CIN | 26 | L 1-6 | 17-9 | 2 | 20,900 | Mark Mulder | Bronson Arroyo | Bronson Arroyo | Mark Mulder | | 126 | 99 | 27 |
| 2006-05-02 | @ CIN | 27 | L 2-3 | 17-10 | 3 | 25,127 | Sidney Ponson | David Williams | Todd Coffey | Brian Falkenborg | | 128 | 102 | 26 |
| 2006-05-03 | @ HOU | 28 | L 4-5 | 17-11 | 3 | 37,305 | Jason Marquis | Roy Oswalt | Roy Oswalt | Jason Marquis | Brad Lidge | 132 | 107 | 25 |
| 2006-05-04 | @ HOU | 29 | L 3-4 | 17-12 | 3 | 37,290 | Chris Carpenter | Andy Pettitte | Andy Pettitte | Chris Carpenter | Brad Lidge | 135 | 111 | 24 |
| 2006-05-05 | @ FLO | 30 | W 7-2 | 18-12 | 3 | 13,266 | Jeff Suppan | Sergio Mitre | Jeff Suppan | Sergio Mitre | | 142 | 113 | 29 |
| 2006-05-06 | @ FLO | 31 | W 7-6 | 19-12 | 3 | 14,369 | Mark Mulder | Dontrelle Willis | Mark Mulder | Dontrelle Willis | Jason Isringhausen | 149 | 119 | 30 |
| 2006-05-07 | @ FLO | 32 | W 9-1 | 20-12 | 2 | 13,057 | Sidney Ponson | Scott Olsen | Josh Hancock | Scott Olsen | | 158 | 120 | 38 |
| 2006-05-08 | vs COL | 33 | L 2-6 | 20-13 | 2 | 39,007 | Jason Marquis | Jeff Francis | Jeff Francis | Jason Marquis | Brian Fuentes | 160 | 126 | 34 |
| 2006-05-09 | vs COL | 34 | W 4-2 | 21-13 | 2 | 40,375 | Chris Carpenter | Josh Fogg | Adam Wainwright | Jose Mesa | Jason Isringhausen | 164 | 128 | 36 |
| 2006-05-10 | vs COL | 35 | W 7-4 | 22-13 | 2 | 39,108 | Jeff Suppan | Byung-Hyun Kim | Jeff Suppan | Byung-Hyun Kim | Jason Isringhausen | 171 | 132 | 39 |
| 2006-05-12 | vs ARI | 36 | W 5-3 | 23-13 | 2 | 41,085 | Mark Mulder | Juan Cruz | Mark Mulder | Juan Cruz | Jason Isringhausen | 176 | 135 | 41 |
| 2006-05-13 | vs ARI | 37 | W 9-1 | 24-13 | 1 | 40,585 | Jason Marquis | Claudio Vargas | Jason Marquis | Claudio Vargas | | 185 | 136 | 49 |
| 2006-05-14 | vs ARI | 38 | L 6-7 | 24-14 | 1 | 40,891 | Chris Carpenter | Miguel Batista | Luis Vizcaino | Adam Wainwright | Jose Valverde | 191 | 143 | 48 |
| 2006-05-16 | vs NYN | 39 | L 3-8 | 24-15 | 1 | 39,616 | Jeff Suppan | Tom Glavine | Tom Glavine | Jeff Suppan | | 194 | 151 | 43 |
| 2006-05-17 | vs NYN | 40 | W 1-0 | 25-15 | 1 | 40,573 | Mark Mulder | Steve Trachsel | Mark Mulder | Steve Trachsel | Jason Isringhausen | 195 | 151 | 44 |
| 2006-05-18 | vs NYN | 41 | W 6-3 | 26-15 | 1 | 41,273 | Jason Marquis | Jose Lima | Jason Marquis | Jose Lima | Jason Isringhausen | 201 | 154 | 47 |
| 2006-05-19 | @ KCA | 42 | W 9-6 | 27-15 | 1 | 33,045 | Chris Carpenter | Mark Redman | Chris Carpenter | Mark Redman | Adam Wainwright | 210 | 160 | 50 |
| 2006-05-20 | @ KCA | 43 | W 4-2 | 28-15 | 1 | 40,516 | Anthony Reyes | Denny Bautista | Anthony Reyes | Denny Bautista | Jason Isringhausen | 214 | 162 | 52 |
| 2006-05-21 | @ KCA | 44 | W 10-3 | 29-15 | 1 | 30,266 | Jeff Suppan | Scott Elarton | Jeff Suppan | Scott Elarton | | 224 | 165 | 59 |
| 2006-05-22 | @ SFN | 45 | L 2-9 | 29-16 | 1 | 38,133 | Mark Mulder | Jamey Wright | Jamey Wright | Mark Mulder | | 226 | 174 | 52 |
| 2006-05-23 | @ SFN | 46 | W 8-5 | 30-16 | 1 | 37,986 | Jason Marquis | Matt Morris | Jason Marquis | Matt Morris | Jason Isringhausen | 234 | 179 | 55 |
| 2006-05-24 | @ SFN | 47 | W 10-4 | 31-16 | 1 | 37,752 | Brad Thompson | Noah Lowry | Adam Wainwright | Noah Lowry | | 244 | 183 | 61 |
| 2006-05-26 | @ SDN | 48 | L 1-7 | 31-17 | 1 | 40,075 | Jeff Suppan | Clay Hensley | Clay Hensley | Jeff Suppan | | 245 | 190 | 55 |
| 2006-05-27 | @ SDN | 49 | W 4-3 | 32-17 | 1 | 32,722 | Sidney Ponson | Chan Ho Park | Sidney Ponson | Chan Ho Park | Jason Isringhausen | 249 | 193 | 56 |
| 2006-05-28 | @ SDN | 50 | L 8-10 | 32-18 | 1 | 38,145 | Mark Mulder | Jake Peavy | Jake Peavy | Mark Mulder | Trevor Hoffman | 257 | 203 | 54 |
| 2006-05-29 | vs HOU | 51 | W 3-1 | 33-18 | 1 | 45,509 | Jason Marquis | Roy Oswalt | Jason Marquis | Trever Miller | Jason Isringhausen | 260 | 204 | 56 |
| 2006-05-30 | vs HOU | 52 | L 3-6 | 33-19 | 1 | 44,732 | Anthony Reyes | Andy Pettitte | Andy Pettitte | Josh Hancock | Brad Lidge | 263 | 210 | 53 |
| 2006-05-31 | vs HOU | 53 | W 4-3 | 34-19 | 1 | 43,534 | Jeff Suppan | Taylor Buchholz | Braden Looper | Mike Gallo | | 267 | 213 | 54 |
| 2006-06-02 | vs CHN | 54 | L 4-5 | 34-20 | 1 | 45,799 | Sidney Ponson | Sean Marshall | Ryan Dempster | Josh Hancock | | 271 | 218 | 53 |
| 2006-06-03 | vs CHN | 55 | L 5-8 | 34-21 | 1 | 45,820 | Mark Mulder | Glendon Rusch | Glendon Rusch | Mark Mulder | Bob Howry | 276 | 226 | 50 |
| 2006-06-04 | vs CHN | 56 | W 9-6 | 35-21 | 1 | 45,753 | Jason Marquis | Greg Maddux | Jason Marquis | Greg Maddux | Jason Isringhausen | 285 | 232 | 53 |
| 2006-06-05 | vs CIN | 57 | L 7-8 | 35-22 | 1 | 43,707 | Jeff Suppan | Brandon Claussen | Esteban Yan | Jason Isringhausen | Todd Coffey | 292 | 240 | 52 |
| 2006-06-06 | vs CIN | 58 | L 0-7 | 35-23 | 1 | 43,857 | Chris Carpenter | Eric Milton | Eric Milton | Chris Carpenter | | 292 | 247 | 45 |
| 2006-06-07 | vs CIN | 59 | L 4-7 | 35-24 | 2 | 44,306 | Sidney Ponson | Aaron Harang | Aaron Harang | Sidney Ponson | Todd Coffey | 296 | 254 | 42 |
| 2006-06-09 | @ MIL | 60 | W 10-6 | 36-24 | 1 | 24,490 | Mark Mulder | Jorge de la Rosa | Josh Hancock | Joe Winkelsas | Jason Isringhausen | 306 | 260 | 46 |
| 2006-06-10 | @ MIL | 61 | L 3-4 | 36-25 | 1 | 36,981 | Jason Marquis | Chris Capuano | Matt Wise | Randy Flores | Derrick Turnbow | 309 | 264 | 45 |
| 2006-06-11 | @ MIL | 62 | W 7-5 | 37-25 | 1 | 29,122 | Jeff Suppan | David Bush | Josh Hancock | David Bush | Jason Isringhausen | 316 | 269 | 47 |
| 2006-06-13 | @ PIT | 63 | W 2-1 | 38-25 | 1 | 24,443 | Chris Carpenter | Oliver Perez | Chris Carpenter | Oliver Perez | Jason Isringhausen | 318 | 270 | 48 |
| 2006-06-14 | @ PIT | 64 | L 7-9 | 38-26 | 1 | 20,289 | Sidney Ponson | Zach Duke | Zach Duke | Sidney Ponson | Mike Gonzalez | 325 | 279 | 46 |
| 2006-06-15 | @ PIT | 65 | W 6-5 | 39-26 | 1 | 18,248 | Mark Mulder | Victor Santos | Mark Mulder | Victor Santos | Jason Isringhausen | 331 | 284 | 47 |
| 2006-06-16 | vs COL | 66 | W 8-1 | 40-26 | 1 | 45,736 | Jason Marquis | Aaron Cook | Jason Marquis | Aaron Cook | | 339 | 285 | 54 |
| 2006-06-17 | vs COL | 67 | W 6-5 | 41-26 | 1 | 45,968 | Jeff Suppan | Jeff Francis | Jeff Suppan | Jeff Francis | Jason Isringhausen | 345 | 290 | 55 |
| 2006-06-18 | vs COL | 68 | W 4-1 | 42-26 | 1 | 45,647 | Chris Carpenter | Josh Fogg | Chris Carpenter | Josh Fogg | Jason Isringhausen | 349 | 291 | 58 |
| 2006-06-20 | @ CHA | 69 | L 6-20 | 42-27 | 1 | 39,463 | Mark Mulder | Javier Vazquez | Javier Vazquez | Mark Mulder | | 355 | 311 | 44 |
| 2006-06-21 | @ CHA | 70 | L 5-13 | 42-28 | 1 | 37,897 | Jason Marquis | Mark Buehrle | Mark Buehrle | Jason Marquis | | 360 | 324 | 36 |
| 2006-06-22 | @ CHA | 71 | L 0-1 | 42-29 | 1 | 39,509 | Anthony Reyes | Freddy Garcia | Freddy Garcia | Anthony Reyes | Bobby Jenks | 360 | 325 | 35 |
| 2006-06-23 | @ DET | 72 | L 6-10 | 42-30 | 1 | 42,238 | Chris Carpenter | Justin Verlander | Justin Verlander | Chris Carpenter | | 366 | 335 | 31 |
| 2006-06-24 | @ DET | 73 | L 6-7 | 42-31 | 1 | 42,535 | Jeff Suppan | Kenny Rogers | Joel Zumaya | Tyler Johnson | | 372 | 342 | 30 |
| 2006-06-25 | @ DET | 74 | L 1-4 | 42-32 | 1 | 40,644 | Sidney Ponson | Jeremy Bonderman | Wil Ledezma | Sidney Ponson | Todd Jones | 373 | 346 | 27 |
| 2006-06-26 | vs CLE | 75 | L 3-10 | 42-33 | 1 | 44,659 | Jason Marquis | Cliff Lee | Cliff Lee | Jason Marquis | | 376 | 356 | 20 |
| 2006-06-27 | vs CLE | 76 | L 1-3 | 42-34 | 1 | 44,446 | Anthony Reyes | CC Sabathia | CC Sabathia | Anthony Reyes | Bob Wickman | 377 | 359 | 18 |
| 2006-06-28 | vs CLE | 77 | W 5-4 | 43-34 | 1 | 44,628 | Chris Carpenter | Jake Westbrook | Jason Isringhausen | Bob Wickman | | 382 | 363 | 19 |
| 2006-06-30 | vs KCA | 78 | L 5-7 | 43-35 | 1 | 45,884 | Jeff Suppan | Brandon Duckworth | Ambiorix Burgos | Braden Looper | | 387 | 370 | 17 |
| 2006-07-01 | vs KCA | 79 | L 7-8 | 43-36 | 1 | 45,035 | Sidney Ponson | Mark Redman | Luke Hudson | Jason Isringhausen | | 394 | 378 | 16 |
| 2006-07-02 | vs KCA | 80 | W 9-7 | 44-36 | 1 | 45,400 | Jason Marquis | Mike Wood | Jason Marquis | Mike Wood | | 403 | 385 | 18 |
| 2006-07-03 | @ ATL | 81 | L 3-6 | 44-37 | 1 | 40,011 | Anthony Reyes | John Smoltz | John Smoltz | Anthony Reyes | Jorge Sosa | 406 | 391 | 15 |
| 2006-07-04 | @ ATL | 82 | W 6-3 | 45-37 | 1 | 47,514 | Chris Carpenter | John Thomson | Chris Carpenter | John Thomson | Jason Isringhausen | 412 | 394 | 18 |
| 2006-07-05 | @ ATL | 83 | L 4-14 | 45-38 | 1 | 28,705 | Jeff Suppan | Chuck James | Chuck James | Jeff Suppan | | 416 | 408 | 8 |
| 2006-07-06 | @ HOU | 84 | L 2-4 | 45-39 | 1 | 41,528 | Sidney Ponson | Taylor Buchholz | Taylor Buchholz | Sidney Ponson | Brad Lidge | 418 | 412 | 6 |
| 2006-07-07 | @ HOU | 85 | W 8-2 | 46-39 | 1 | 43,236 | Jason Marquis | Wandy Rodriguez | Jason Marquis | Wandy Rodriguez | Jason Isringhausen | 426 | 414 | 12 |
| 2006-07-08 | @ HOU | 86 | W 7-6 | 47-39 | 1 | 43,424 | Anthony Reyes | Roger Clemens | Jason Isringhausen | Roy Oswalt | | 433 | 420 | 13 |
| 2006-07-09 | @ HOU | 87 | W 7-5 | 48-39 | 1 | 41,652 | Chris Carpenter | Andy Pettitte | Braden Looper | Brad Lidge | Josh Hancock | 440 | 425 | 15 |
| 2006-07-13 | vs LAN | 88 | W 3-2 | 49-39 | 1 | 45,156 | Jason Marquis | Chad Billingsley | Braden Looper | Odalis Perez | | 443 | 427 | 16 |
| 2006-07-14 | vs LAN | 89 | W 5-0 | 50-39 | 1 | 45,704 | Chris Carpenter | Derek Lowe | Chris Carpenter | Derek Lowe | | 448 | 427 | 21 |
| 2006-07-15 | vs LAN | 90 | W 2-1 | 51-39 | 1 | 46,068 | Jeff Suppan | Mark Hendrickson | Braden Looper | Danys Baez | | 450 | 428 | 22 |
| 2006-07-16 | vs LAN | 91 | W 11-3 | 52-39 | 1 | 44,741 | Anthony Reyes | Brad Penny | Anthony Reyes | Brad Penny | | 461 | 431 | 30 |
| 2006-07-17 | vs ATL | 92 | L 3-15 | 52-40 | 1 | 44,507 | Jeff Weaver | Horacio Ramirez | Horacio Ramirez | Jeff Weaver | | 464 | 446 | 18 |
| 2006-07-18 | vs ATL | 93 | L 5-14 | 52-41 | 1 | 44,718 | Jason Marquis | Tim Hudson | Tim Hudson | Jason Marquis | | 469 | 460 | 9 |
| 2006-07-19 | vs ATL | 94 | W 8-3 | 53-41 | 1 | 43,991 | Chris Carpenter | Jason Shiell | Chris Carpenter | Jason Shiell | | 477 | 463 | 14 |
| 2006-07-21 | @ LAN | 95 | W 2-0 | 54-41 | 1 | 47,987 | Jeff Suppan | Brad Penny | Jeff Suppan | Brad Penny | Jason Isringhausen | 479 | 463 | 16 |
| 2006-07-22 | @ LAN | 96 | W 6-1 | 55-41 | 1 | 50,438 | Jeff Weaver | Aaron Sele | Jeff Weaver | Aaron Sele | | 485 | 464 | 21 |
| 2006-07-23 | @ LAN | 97 | W 6-1 | 56-41 | 1 | 43,650 | Jason Marquis | Chad Billingsley | Jason Marquis | Chad Billingsley | | 491 | 465 | 26 |
| 2006-07-24 | @ COL | 98 | L 0-7 | 56-42 | 1 | 28,830 | Anthony Reyes | Jeff Francis | Jeff Francis | Anthony Reyes | | 491 | 472 | 19 |
| 2006-07-25 | @ COL | 99 | W 1-0 | 57-42 | 1 | 31,673 | Chris Carpenter | Jason Jennings | Chris Carpenter | Jason Jennings | Jason Isringhausen | 492 | 472 | 20 |
| 2006-07-26 | @ COL | 100 | W 6-1 | 58-42 | 1 | 32,872 | Jeff Suppan | Aaron Cook | Jeff Suppan | Aaron Cook | | 498 | 473 | 25 |
| 2006-07-27 | @ CHN | 101 | L 4-5 | 58-43 | 1 | 40,346 | Jeff Weaver | Rich Hill | Roberto Novoa | Tyler Johnson | Ryan Dempster | 502 | 478 | 24 |
| 2006-07-28 | @ CHN | 102 | L 5-6 | 58-44 | 1 | 40,420 | Jason Marquis | Carlos Marmol | Carlos Marmol | Jason Marquis | Ryan Dempster | 507 | 484 | 23 |
| 2006-07-29 | @ CHN | 103 | L 2-4 | 58-45 | 1 | 41,302 | Anthony Reyes | Greg Maddux | Greg Maddux | Anthony Reyes | Ryan Dempster | 509 | 488 | 21 |
| 2006-07-30 | @ CHN | 104 | L 3-6 | 58-46 | 1 | 40,033 | Chris Carpenter | Carlos Zambrano | Carlos Zambrano | Chris Carpenter | | 512 | 494 | 18 |
| 2006-08-01 | vs PHI | 105 | L 3-5 | 58-47 | 1 | 42,773 | Jeff Suppan | Scott Mathieson | Scott Mathieson | Jeff Suppan | Tom Gordon | 515 | 499 | 16 |
| 2006-08-02 | vs PHI | 106 | L 8-16 | 58-48 | 1 | 42,598 | Jeff Weaver | Brett Myers | Brett Myers | Jeff Weaver | | 523 | 515 | 8 |
| 2006-08-03 | vs PHI | 107 | L 1-8 | 58-49 | 1 | 42,461 | Jason Marquis | Cole Hamels | Cole Hamels | Jason Marquis | | 524 | 523 | 1 |
| 2006-08-04 | vs MIL | 108 | L 3-4 | 58-50 | 1 | 43,162 | Chris Carpenter | Doug Davis | Doug Davis | Chris Carpenter | Francisco Cordero | 527 | 527 | 0 |
| 2006-08-05 | vs MIL | 109 | W 4-3 | 59-50 | 1 | 43,299 | Anthony Reyes | Ben Sheets | Anthony Reyes | Ben Sheets | Jason Isringhausen | 531 | 530 | 1 |
| 2006-08-06 | vs MIL | 110 | W 7-1 | 60-50 | 1 | 43,140 | Jeff Suppan | Chris Capuano | Jeff Suppan | Chris Capuano | Jorge Sosa | 538 | 531 | 7 |
| 2006-08-07 | @ CIN | 111 | W 13-1 | 61-50 | 1 | 34,262 | Jeff Weaver | Elizardo Ramirez | Jeff Weaver | Elizardo Ramirez | | 551 | 532 | 19 |
| 2006-08-08 | @ CIN | 112 | L 3-10 | 61-51 | 1 | 40,094 | Jason Marquis | Eric Milton | Eric Milton | Jason Marquis | | 554 | 542 | 12 |
| 2006-08-09 | @ CIN | 113 | L 7-8 | 61-52 | 1 | 41,649 | Chris Carpenter | Aaron Harang | Ryan Franklin | Jason Isringhausen | | 561 | 550 | 11 |
| 2006-08-10 | @ CIN | 114 | W 6-1 | 62-52 | 1 | 39,591 | Anthony Reyes | Bronson Arroyo | Anthony Reyes | Bronson Arroyo | | 567 | 551 | 16 |
| 2006-08-11 | @ PIT | 115 | L 1-7 | 62-53 | 1 | 30,516 | Jeff Suppan | Zach Duke | Zach Duke | Jeff Suppan | | 568 | 558 | 10 |
| 2006-08-12 | @ PIT | 116 | L 2-3 | 62-54 | 1 | 35,037 | Jeff Weaver | Ian Snell | Ian Snell | Jeff Weaver | Mike Gonzalez | 570 | 561 | 9 |
| 2006-08-13 | @ PIT | 117 | L 0-7 | 62-55 | 1 | 27,101 | Jason Marquis | Paul Maholm | Paul Maholm | Jason Marquis | | 570 | 568 | 2 |
| 2006-08-15 | vs CIN | 118 | W 5-0 | 63-55 | 1 | 42,761 | Chris Carpenter | Aaron Harang | Chris Carpenter | Aaron Harang | | 575 | 568 | 7 |
| 2006-08-16 | vs CIN | 119 | L 2-7 | 63-56 | 1 | 42,752 | Anthony Reyes | Bronson Arroyo | Bronson Arroyo | Anthony Reyes | | 577 | 575 | 2 |
| 2006-08-17 | vs CIN | 120 | W 2-1 | 64-56 | 1 | 40,346 | Jeff Weaver | Kyle Lohse | Jason Isringhausen | Ryan Franklin | | 579 | 576 | 3 |
| 2006-08-18 | @ CHN | 121 | W 11-3 | 65-56 | 1 | 40,346 | Jason Marquis | Carlos Marmol | Jason Marquis | Carlos Marmol | | 590 | 579 | 11 |
| 2006-08-19 | @ CHN | 122 | L 4-5 | 65-57 | 1 | 40,864 | Jeff Suppan | Carlos Zambrano | Michael Wuertz | Jason Isringhausen | | 594 | 584 | 10 |
| 2006-08-20 | @ CHN | 123 | W 5-3 | 66-57 | 1 | 40,485 | Chris Carpenter | Juan Mateo | Chris Carpenter | Juan Mateo | Jason Isringhausen | 599 | 587 | 12 |
| 2006-08-22 | @ NYN | 124 | L 7-8 | 66-58 | 1 | 49,661 | Jeff Weaver | John Maine | Aaron Heilman | Jason Isringhausen | | 606 | 595 | 11 |
| 2006-08-23 | @ NYN | 125 | L 8-10 | 66-59 | 1 | 49,329 | Mark Mulder | Steve Trachsel | Steve Trachsel | Mark Mulder | Billy Wagner | 614 | 605 | 9 |
| 2006-08-24 | @ NYN | 126 | L 2-6 | 66-60 | 1 | 45,497 | Jason Marquis | David Williams | David Williams | Jason Marquis | | 616 | 611 | 5 |
| 2006-08-25 | vs CHN | 127 | W 2-0 | 67-60 | 1 | 46,004 | Jeff Suppan | Juan Mateo | Jeff Suppan | Juan Mateo | Jason Isringhausen | 618 | 611 | 7 |
| 2006-08-26 | vs CHN | 128 | W 2-1 | 68-60 | 1 | 46,036 | Chris Carpenter | Rich Hill | Randy Flores | Roberto Novoa | | 620 | 612 | 8 |
| 2006-08-27 | vs CHN | 129 | W 10-6 | 69-60 | 1 | 44,937 | Jeff Weaver | Les Walrond | Braden Looper | Bob Howry | | 630 | 618 | 12 |
| 2006-08-29 | vs FLO | 130 | L 1-9 | 69-61 | 1 | 40,663 | Mark Mulder | Scott Olsen | Scott Olsen | Mark Mulder | | 631 | 627 | 4 |
| 2006-08-30 | vs FLO | 131 | W 13-6 | 70-61 | 1 | 41,322 | Jason Marquis | Ricky Nolasco | Jason Marquis | Ricky Nolasco | | 644 | 633 | 11 |
| 2006-08-31 | vs FLO | 132 | W 5-2 | 71-61 | 1 | 40,989 | Jeff Suppan | Dontrelle Willis | Braden Looper | Sergio Mitre | Jason Isringhausen | 649 | 635 | 14 |
| 2006-09-01 | vs PIT | 133 | W 3-1 | 72-61 | 1 | 42,091 | Chris Carpenter | Zach Duke | Chris Carpenter | Zach Duke | | 652 | 636 | 16 |
| 2006-09-02 | vs PIT | 134 | L 0-1 | 72-62 | 1 | 41,466 | Jeff Weaver | Shawn Chacon | Matt Capps | Jeff Weaver | Salomon Torres | 652 | 637 | 15 |
| 2006-09-03 | vs PIT | 135 | W 6-3 | 73-62 | 1 | 42,205 | Anthony Reyes | Ian Snell | Anthony Reyes | Ian Snell | | 658 | 640 | 18 |
| 2006-09-04 | @ WAS | 136 | L 1-4 | 73-63 | 1 | 31,092 | Jason Marquis | Ramon Ortiz | Ramon Ortiz | Jason Marquis | | 659 | 644 | 15 |
| 2006-09-05 | @ WAS | 137 | W 2-0 | 74-63 | 1 | 25,937 | Jeff Suppan | Pedro Astacio | Jeff Suppan | Pedro Astacio | Jason Isringhausen | 661 | 644 | 17 |
| 2006-09-06 | @ WAS | 138 | L 6-7 | 74-64 | 1 | 21,322 | Chris Carpenter | Mike O'Connor | Chad Cordero | Jason Isringhausen | | 667 | 651 | 16 |
| 2006-09-07 | @ ARI | 139 | W 6-2 | 75-64 | 1 | 29,998 | Jeff Weaver | Miguel Batista | Jeff Weaver | Miguel Batista | | 673 | 653 | 20 |
| 2006-09-08 | @ ARI | 140 | L 1-13 | 75-65 | 1 | 25,299 | Anthony Reyes | Livan Hernandez | Livan Hernandez | Anthony Reyes | | 674 | 666 | 8 |
| 2006-09-09 | @ ARI | 141 | L 0-3 | 75-66 | 1 | 33,619 | Jason Marquis | Brandon Webb | Brandon Webb | Jason Marquis | | 674 | 669 | 5 |
| 2006-09-10 | @ ARI | 142 | L 7-9 | 75-67 | 1 | 25,381 | Jeff Suppan | Enrique Gonzalez | Luis Vizcaino | Jorge Sosa | Jose Valverde | 681 | 678 | 3 |
| 2006-09-11 | vs HOU | 143 | W 7-0 | 76-67 | 1 | 41,061 | Chris Carpenter | Taylor Buchholz | Chris Carpenter | Taylor Buchholz | | 688 | 678 | 10 |
| 2006-09-12 | vs HOU | 144 | W 6-5 | 77-67 | 1 | 41,453 | Jeff Weaver | Andy Pettitte | Braden Looper | Brad Lidge | | 694 | 683 | 11 |
| 2006-09-13 | vs HOU | 145 | L 1-5 | 77-68 | 1 | 40,459 | Jason Marquis | Roy Oswalt | Roy Oswalt | Jason Marquis | Dan Wheeler | 695 | 688 | 7 |
| 2006-09-15 | vs SFN | 146 | W 14-4 | 78-68 | 1 | 45,927 | Jeff Suppan | Brad Hennessey | Jeff Suppan | Brad Hennessey | | 709 | 692 | 17 |
| 2006-09-16 | vs SFN | 147 | W 6-1 | 79-68 | 1 | 45,445 | Chris Carpenter | Matt Morris | Chris Carpenter | Matt Morris | | 715 | 693 | 22 |
| 2006-09-18 | @ MIL | 148 | L 3-4 | 79-69 | 1 | 19,360 | Anthony Reyes | Chris Capuano | Francisco Cordero | Braden Looper | | 718 | 697 | 21 |
| 2006-09-19 | @ MIL | 149 | W 12-2 | 80-69 | 1 | 15,204 | Jeff Weaver | Ben Sheets | Jeff Weaver | Ben Sheets | | 730 | 699 | 31 |
| 2006-09-20 | @ MIL | 150 | L 0-1 | 80-70 | 1 | 14,242 | Jeff Suppan | Carlos Villanueva | Francisco Cordero | Tyler Johnson | | 730 | 700 | 30 |
| 2006-09-21 | @ HOU | 151 | L 5-6 | 80-71 | 1 | 32,975 | Chris Carpenter | Andy Pettitte | Dave Borkowski | Chris Carpenter | Dan Wheeler | 735 | 706 | 29 |
| 2006-09-22 | @ HOU | 152 | L 5-6 | 80-72 | 1 | 39,616 | Chris Narveson | Jason Hirsh | Chad Qualls | Braden Looper | | 740 | 712 | 28 |
| 2006-09-23 | @ HOU | 153 | L 4-7 | 80-73 | 1 | 43,469 | Jason Marquis | Roy Oswalt | Dan Wheeler | Tyler Johnson | | 744 | 719 | 25 |
| 2006-09-24 | @ HOU | 154 | L 3-7 | 80-74 | 1 | 43,704 | Jeff Weaver | Roger Clemens | Chad Qualls | Josh Hancock | | 747 | 726 | 21 |
| 2006-09-25 | vs SDN | 155 | L 5-6 | 80-75 | 1 | 40,149 | Jeff Suppan | Mike Thompson | Scott Cassidy | Brad Thompson | Scott Linebrink | 752 | 732 | 20 |
| 2006-09-26 | vs SDN | 156 | L 5-7 | 80-76 | 1 | 40,443 | Chris Carpenter | Woody Williams | Woody Williams | Chris Carpenter | Trevor Hoffman | 757 | 739 | 18 |
| 2006-09-27 | vs SDN | 157 | W 4-2 | 81-76 | 1 | 40,358 | Anthony Reyes | Chris Young | Tyler Johnson | Scott Linebrink | Adam Wainwright | 761 | 741 | 20 |
| 2006-09-28 | vs MIL | 158 | L 4-9 | 81-77 | 1 | 40,313 | Jason Marquis | Doug Davis | Doug Davis | Jason Marquis | | 765 | 750 | 15 |
| 2006-09-29 | vs MIL | 159 | W 10-5 | 82-77 | 1 | 41,718 | Jeff Weaver | Chris Capuano | Jeff Weaver | Chris Capuano | | 775 | 755 | 20 |
| 2006-09-30 | vs MIL | 160 | W 3-2 | 83-77 | 1 | 44,294 | Jeff Suppan | Ben Sheets | Tyler Johnson | Brian Shouse | Adam Wainwright | 778 | 757 | 21 |
| 2006-10-01 | vs MIL | 161 | L 3-5 | 83-78 | 1 | 44,133 | Anthony Reyes | Carlos Villanueva | Carlos Villanueva | Anthony Reyes | | 781 | 762 | 19 |