| 2006-04-03 | @ OAK | 1 | W 15-2 | 1-0 | 3 | 35,077 | Randy Johnson | Barry Zito | Randy Johnson | Barry Zito | | 15 | 2 | 13 |
| 2006-04-04 | @ OAK | 2 | L 3-4 | 1-1 | 4 | 31,284 | Mike Mussina | Rich Harden | Huston Street | Scott Proctor | | 18 | 6 | 12 |
| 2006-04-05 | @ OAK | 3 | L 4-9 | 1-2 | 4 | 30,165 | Chien-Ming Wang | Dan Haren | Joe Kennedy | Jaret Wright | | 22 | 15 | 7 |
| 2006-04-07 | @ ANA | 4 | L 1-4 | 1-3 | 5 | 44,221 | Shawn Chacon | Kelvim Escobar | Kelvim Escobar | Shawn Chacon | Francisco Rodriguez | 23 | 19 | 4 |
| 2006-04-08 | @ ANA | 5 | L 2-3 | 1-4 | 5 | 44,044 | Randy Johnson | Ervin Santana | Ervin Santana | Randy Johnson | Francisco Rodriguez | 25 | 22 | 3 |
| 2006-04-09 | @ ANA | 6 | W 10-1 | 2-4 | 5 | 44,020 | Mike Mussina | Bartolo Colon | Mike Mussina | Bartolo Colon | | 35 | 23 | 12 |
| 2006-04-11 | vs KCA | 7 | W 9-7 | 3-4 | 3 | 54,698 | Chien-Ming Wang | Joe Mays | Scott Proctor | Andy Sisco | Mariano Rivera | 44 | 30 | 14 |
| 2006-04-12 | vs KCA | 8 | W 12-5 | 4-4 | 2 | 41,448 | Shawn Chacon | Jeremy Affeldt | Shawn Chacon | Jeremy Affeldt | | 56 | 35 | 21 |
| 2006-04-13 | vs KCA | 9 | W 9-3 | 5-4 | 2 | 54,381 | Randy Johnson | Denny Bautista | Randy Johnson | Denny Bautista | | 65 | 38 | 27 |
| 2006-04-14 | @ MIN | 10 | L 1-5 | 5-5 | 4 | 30,622 | Mike Mussina | Scott Baker | Scott Baker | Mike Mussina | | 66 | 43 | 23 |
| 2006-04-15 | @ MIN | 11 | L 5-6 | 5-6 | 5 | 42,316 | Jaret Wright | Johan Santana | Juan Rincon | Mariano Rivera | | 71 | 49 | 22 |
| 2006-04-16 | @ MIN | 12 | W 9-3 | 6-6 | 4 | 22,627 | Chien-Ming Wang | Brad Radke | Chien-Ming Wang | Brad Radke | | 80 | 52 | 28 |
| 2006-04-18 | @ TOR | 13 | L 5-10 | 6-7 | 5 | 48,776 | Randy Johnson | Gustavo Chacin | Gustavo Chacin | Randy Johnson | | 85 | 62 | 23 |
| 2006-04-19 | @ TOR | 14 | W 3-1 | 7-7 | 3 | 32,886 | Mike Mussina | Ted Lilly | Mike Mussina | Ted Lilly | Mariano Rivera | 88 | 63 | 25 |
| 2006-04-21 | vs BAL | 15 | L 5-6 | 7-8 | 5 | 51,282 | Chien-Ming Wang | Kris Benson | Kris Benson | Chien-Ming Wang | Chris Ray | 93 | 69 | 24 |
| 2006-04-22 | vs BAL | 16 | W 6-1 | 8-8 | 4 | 50,872 | Shawn Chacon | Daniel Cabrera | Shawn Chacon | Daniel Cabrera | | 99 | 70 | 29 |
| 2006-04-23 | vs BAL | 17 | W 7-1 | 9-8 | 3 | 47,996 | Randy Johnson | Bruce Chen | Randy Johnson | Bruce Chen | | 106 | 71 | 35 |
| 2006-04-25 | vs TBA | 18 | W 9-1 | 10-8 | 2 | 36,334 | Mike Mussina | Scott Kazmir | Mike Mussina | Scott Kazmir | | 115 | 72 | 43 |
| 2006-04-26 | vs TBA | 19 | L 2-4 | 10-9 | 3 | 35,642 | Chien-Ming Wang | Seth McClung | Chad Orvella | Mariano Rivera | Shawn Camp | 117 | 76 | 41 |
| 2006-04-27 | vs TBA | 20 | W 4-1 | 11-9 | 2 | 45,826 | Shawn Chacon | Mark Hendrickson | Shawn Chacon | Mark Hendrickson | Mariano Rivera | 121 | 77 | 44 |
| 2006-04-28 | vs TOR | 21 | L 2-7 | 11-10 | 4 | 47,204 | Jaret Wright | Roy Halladay | Roy Halladay | Jaret Wright | B.J. Ryan | 123 | 84 | 39 |
| 2006-04-29 | vs TOR | 22 | W 17-6 | 12-10 | 2 | 50,119 | Randy Johnson | Josh Towers | Randy Johnson | Josh Towers | | 140 | 90 | 50 |
| 2006-04-30 | vs TOR | 23 | W 4-1 | 13-10 | 1 | 52,954 | Mike Mussina | Gustavo Chacin | Mike Mussina | Gustavo Chacin | Mariano Rivera | 144 | 91 | 53 |
| 2006-05-01 | @ BOS | 24 | L 3-7 | 13-11 | 2 | 36,339 | Chien-Ming Wang | Tim Wakefield | Mike Timlin | Aaron Small | | 147 | 98 | 49 |
| 2006-05-03 | @ TBA | 25 | W 4-2 | 14-11 | 1 | 17,059 | Jaret Wright | Casey Fossum | Kyle Farnsworth | Tyler Walker | Mariano Rivera | 151 | 100 | 51 |
| 2006-05-04 | @ TBA | 26 | W 10-5 | 15-11 | 1 | 22,164 | Randy Johnson | Doug Waechter | Randy Johnson | Chad Orvella | | 161 | 105 | 56 |
| 2006-05-05 | @ TEX | 27 | W 8-7 | 16-11 | 1 | 39,002 | Mike Mussina | Vicente Padilla | Mike Mussina | Vicente Padilla | Mariano Rivera | 169 | 112 | 57 |
| 2006-05-06 | @ TEX | 28 | W 6-1 | 17-11 | 1 | 48,634 | Shawn Chacon | Kameron Loe | Shawn Chacon | Kameron Loe | | 175 | 113 | 62 |
| 2006-05-07 | @ TEX | 29 | W 8-5 | 18-11 | 1 | 46,013 | Chien-Ming Wang | Rob Tejeda | Chien-Ming Wang | Rob Tejeda | | 183 | 118 | 65 |
| 2006-05-09 | vs BOS | 30 | L 3-14 | 18-12 | 2 | 54,688 | Randy Johnson | Josh Beckett | Josh Beckett | Randy Johnson | | 186 | 132 | 54 |
| 2006-05-10 | vs BOS | 31 | W 7-3 | 19-12 | 1 | 54,769 | Mike Mussina | Curt Schilling | Mike Mussina | Curt Schilling | | 193 | 135 | 58 |
| 2006-05-11 | vs BOS | 32 | L 3-5 | 19-13 | 2 | 54,956 | Shawn Chacon | Tim Wakefield | Tim Wakefield | Ron Villone | Jonathan Papelbon | 196 | 140 | 56 |
| 2006-05-12 | vs OAK | 33 | W 2-0 | 20-13 | 1 | 47,497 | Chien-Ming Wang | Barry Zito | Chien-Ming Wang | Barry Zito | Mariano Rivera | 198 | 140 | 58 |
| 2006-05-13 | vs OAK | 34 | W 4-3 | 21-13 | 1 | 53,907 | Jaret Wright | Brad Halsey | Jaret Wright | Brad Halsey | Kyle Farnsworth | 202 | 143 | 59 |
| 2006-05-14 | vs OAK | 35 | L 1-6 | 21-14 | 2 | 52,587 | Randy Johnson | Dan Haren | Dan Haren | Randy Johnson | | 203 | 149 | 54 |
| 2006-05-15 | vs TEX | 36 | L 2-4 | 21-15 | 2 | 41,115 | Mike Mussina | Kevin Millwood | Kevin Millwood | Kyle Farnsworth | Akinori Otsuka | 205 | 153 | 52 |
| 2006-05-16 | vs TEX | 37 | W 14-13 | 22-15 | 2 | 40,757 | Shawn Chacon | John Koronka | Mariano Rivera | Akinori Otsuka | | 219 | 166 | 53 |
| 2006-05-17 | vs TEX | 38 | W 4-3 | 23-15 | 2 | 52,547 | Chien-Ming Wang | Kameron Loe | Chien-Ming Wang | Kameron Loe | Mariano Rivera | 223 | 169 | 54 |
| 2006-05-18 | vs TEX | 39 | L 2-6 | 23-16 | 2 | 47,194 | Jaret Wright | Vicente Padilla | Vicente Padilla | Jaret Wright | | 225 | 175 | 50 |
| 2006-05-19 | @ NYN | 40 | L 6-7 | 23-17 | 2 | 56,289 | Randy Johnson | Geremi Gonzalez | Billy Wagner | Mariano Rivera | | 231 | 182 | 49 |
| 2006-05-20 | @ NYN | 41 | W 5-4 | 24-17 | 2 | 56,185 | Mike Mussina | Pedro Martinez | Mariano Rivera | Jorge Julio | | 236 | 186 | 50 |
| 2006-05-21 | @ NYN | 42 | L 3-4 | 24-18 | 2 | 56,205 | Aaron Small | Tom Glavine | Tom Glavine | Aaron Small | Billy Wagner | 239 | 190 | 49 |
| 2006-05-22 | @ BOS | 43 | L 5-9 | 24-19 | 2 | 36,342 | Chien-Ming Wang | Curt Schilling | Curt Schilling | Chien-Ming Wang | | 244 | 199 | 45 |
| 2006-05-23 | @ BOS | 44 | W 7-5 | 25-19 | 2 | 36,290 | Jaret Wright | Tim Wakefield | Jaret Wright | Tim Wakefield | Mariano Rivera | 251 | 204 | 47 |
| 2006-05-24 | @ BOS | 45 | W 8-6 | 26-19 | 2 | 36,375 | Randy Johnson | Matt Clement | Randy Johnson | Matt Clement | Mariano Rivera | 259 | 210 | 49 |
| 2006-05-26 | vs KCA | 46 | L 6-7 | 26-20 | 2 | 48,035 | Mike Mussina | Scott Elarton | Scott Elarton | Kyle Farnsworth | Andy Sisco | 265 | 217 | 48 |
| 2006-05-27 | vs KCA | 47 | W 15-4 | 27-20 | 2 | 54,216 | Chien-Ming Wang | Jeremy Affeldt | Chien-Ming Wang | Jeremy Affeldt | | 280 | 221 | 59 |
| 2006-05-28 | vs KCA | 48 | W 6-5 | 28-20 | 2 | 54,372 | Jaret Wright | Runelvys Hernandez | Jaret Wright | Runelvys Hernandez | Mariano Rivera | 286 | 226 | 60 |
| 2006-05-29 | @ DET | 49 | W 4-0 | 29-20 | 2 | 39,759 | Randy Johnson | Jeremy Bonderman | Randy Johnson | Jeremy Bonderman | | 290 | 226 | 64 |
| 2006-05-30 | @ DET | 50 | W 11-6 | 30-20 | 2 | 24,765 | Aaron Small | Roman Colon | Mariano Rivera | Todd Jones | | 301 | 232 | 69 |
| 2006-05-31 | @ DET | 51 | W 6-1 | 31-20 | 2 | 23,757 | Mike Mussina | Nate Robertson | Mike Mussina | Nate Robertson | | 307 | 233 | 74 |
| 2006-06-01 | @ DET | 52 | L 6-7 | 31-21 | 2 | 27,231 | Chien-Ming Wang | Justin Verlander | Fernando Rodney | Kyle Farnsworth | | 313 | 240 | 73 |
| 2006-06-02 | @ BAL | 53 | W 6-5 | 32-21 | 2 | 48,168 | Jaret Wright | Kris Benson | Kyle Farnsworth | Chris Ray | | 319 | 245 | 74 |
| 2006-06-03 | @ BAL | 54 | W 6-5 | 33-21 | 1 | 48,195 | Randy Johnson | Adam Loewen | Scott Proctor | Chris Ray | Chien-Ming Wang | 325 | 250 | 75 |
| 2006-06-04 | @ BAL | 55 | L 4-11 | 33-22 | 2 | 47,535 | Aaron Small | Rodrigo Lopez | Rodrigo Lopez | Aaron Small | | 329 | 261 | 68 |
| 2006-06-05 | vs BOS | 56 | W 13-5 | 34-22 | 1 | 55,246 | Mike Mussina | Josh Beckett | Mike Mussina | Josh Beckett | | 342 | 266 | 76 |
| 2006-06-06 | vs BOS | 57 | W 2-1 | 35-22 | 1 | 55,141 | Chien-Ming Wang | David Pauley | Chien-Ming Wang | David Pauley | Mariano Rivera | 344 | 267 | 77 |
| 2006-06-08 | vs BOS | 58 | L 3-9 | 35-23 | 1 | 55,225 | Jaret Wright | Curt Schilling | Curt Schilling | Jaret Wright | | 347 | 276 | 71 |
| 2006-06-09 | vs OAK | 59 | L 5-6 | 35-24 | 2 | 53,837 | Randy Johnson | Dan Haren | Dan Haren | Randy Johnson | Huston Street | 352 | 282 | 70 |
| 2006-06-10 | vs OAK | 60 | L 2-5 | 35-25 | 2 | 53,779 | Mike Mussina | Kirk Saarloos | Kirk Saarloos | Mike Mussina | Huston Street | 354 | 287 | 67 |
| 2006-06-11 | vs OAK | 61 | L 5-6 | 35-26 | 2 | 54,570 | Shawn Chacon | Barry Zito | Barry Zito | Kyle Farnsworth | Huston Street | 359 | 293 | 66 |
| 2006-06-13 | vs CLE | 62 | W 1-0 | 36-26 | 2 | 50,365 | Chien-Ming Wang | Paul Byrd | Chien-Ming Wang | Paul Byrd | Mariano Rivera | 360 | 293 | 67 |
| 2006-06-14 | vs CLE | 63 | W 6-1 | 37-26 | 1 | 53,448 | Randy Johnson | Jason Johnson | Randy Johnson | Jason Johnson | | 366 | 294 | 72 |
| 2006-06-15 | vs CLE | 64 | L 4-8 | 37-27 | 1 | 54,648 | Mike Mussina | Cliff Lee | Cliff Lee | Mike Mussina | | 370 | 302 | 68 |
| 2006-06-16 | @ WAS | 65 | W 7-5 | 38-27 | 1 | 44,749 | Jaret Wright | Shawn Hill | Mariano Rivera | Chad Cordero | | 377 | 307 | 70 |
| 2006-06-17 | @ WAS | 66 | L 9-11 | 38-28 | 2 | 45,085 | Shawn Chacon | Ramon Ortiz | Jon Rauch | Mariano Rivera | Chad Cordero | 386 | 318 | 68 |
| 2006-06-18 | @ WAS | 67 | L 2-3 | 38-29 | 2 | 45,157 | Chien-Ming Wang | Mike O'Connor | Gary Majewski | Chien-Ming Wang | | 388 | 321 | 67 |
| 2006-06-19 | @ PHI | 68 | L 2-4 | 38-30 | 2 | 44,747 | Randy Johnson | Brett Myers | Brett Myers | Randy Johnson | Tom Gordon | 390 | 325 | 65 |
| 2006-06-20 | @ PHI | 69 | W 9-7 | 39-30 | 2 | 44,775 | Mike Mussina | Cory Lidle | T.J. Beam | Arthur Rhodes | Mariano Rivera | 399 | 332 | 67 |
| 2006-06-21 | @ PHI | 70 | W 5-0 | 40-30 | 2 | 45,111 | Jaret Wright | Cole Hamels | Jaret Wright | Cole Hamels | | 404 | 332 | 72 |
| 2006-06-23 | vs FLO | 71 | W 6-5 | 41-30 | 2 | 54,025 | Chien-Ming Wang | Brian Moehler | Chien-Ming Wang | Brian Moehler | Mariano Rivera | 410 | 337 | 73 |
| 2006-06-25 | vs FLO | 72 | W 2-1 | 42-31 | 2 | 53,615 | Mike Mussina | Dontrelle Willis | Mike Mussina | Dontrelle Willis | Mariano Rivera | 412 | 338 | 74 |
| 2006-06-25 | vs FLO | 73 | L 0-5 | 42-31 | 2 | 54,361 | Shawn Chacon | Anibal Sanchez | Anibal Sanchez | Shawn Chacon | | 412 | 343 | 69 |
| 2006-06-26 | vs ATL | 74 | W 5-2 | 43-31 | 2 | 54,226 | Randy Johnson | Tim Hudson | Randy Johnson | Tim Hudson | Mariano Rivera | 417 | 345 | 72 |
| 2006-06-27 | vs ATL | 75 | L 2-5 | 43-32 | 2 | 53,763 | Jaret Wright | Horacio Ramirez | Horacio Ramirez | Jaret Wright | | 419 | 350 | 69 |
| 2006-06-28 | vs ATL | 76 | W 4-3 | 44-32 | 2 | 54,186 | Chien-Ming Wang | John Smoltz | Ron Villone | Jorge Sosa | | 423 | 353 | 70 |
| 2006-06-30 | vs NYN | 77 | W 2-0 | 45-32 | 2 | 55,245 | Mike Mussina | Orlando Hernandez | Ron Villone | Orlando Hernandez | Mariano Rivera | 425 | 353 | 72 |
| 2006-07-01 | vs NYN | 78 | L 3-8 | 45-33 | 2 | 55,132 | Randy Johnson | Steve Trachsel | Steve Trachsel | Randy Johnson | | 428 | 361 | 67 |
| 2006-07-02 | vs NYN | 79 | W 16-7 | 46-33 | 2 | 55,212 | Jaret Wright | Alay Soler | Ron Villone | Alay Soler | | 444 | 368 | 76 |
| 2006-07-03 | @ CLE | 80 | L 2-5 | 46-34 | 2 | 42,706 | Chien-Ming Wang | Jeremy Sowers | Jeremy Sowers | Chien-Ming Wang | Bob Wickman | 446 | 373 | 73 |
| 2006-07-04 | @ CLE | 81 | L 1-19 | 46-35 | 2 | 29,638 | Shawn Chacon | Jake Westbrook | Jake Westbrook | Shawn Chacon | | 447 | 392 | 55 |
| 2006-07-05 | @ CLE | 82 | W 11-3 | 47-35 | 2 | 31,265 | Mike Mussina | Paul Byrd | Mike Mussina | Paul Byrd | | 458 | 395 | 63 |
| 2006-07-06 | @ CLE | 83 | W 10-4 | 48-35 | 2 | 34,982 | Randy Johnson | Cliff Lee | Randy Johnson | Cliff Lee | | 468 | 399 | 69 |
| 2006-07-07 | @ TBA | 84 | W 1-0 | 49-35 | 2 | 25,584 | Jaret Wright | Jae Weong Seo | Jaret Wright | Jae Weong Seo | Mariano Rivera | 469 | 399 | 70 |
| 2006-07-08 | @ TBA | 85 | W 5-1 | 50-35 | 2 | 34,787 | Chien-Ming Wang | Scott Kazmir | Chien-Ming Wang | Scott Kazmir | | 474 | 400 | 74 |
| 2006-07-09 | @ TBA | 86 | L 5-6 | 50-36 | 2 | 31,583 | Kris Wilson | Casey Fossum | Tim Corcoran | Scott Proctor | Brian Meadows | 479 | 406 | 73 |
| 2006-07-14 | vs CHA | 87 | W 6-5 | 51-36 | 2 | 55,069 | Randy Johnson | Jose Contreras | Kyle Farnsworth | Jose Contreras | Mariano Rivera | 485 | 411 | 74 |
| 2006-07-15 | vs CHA | 88 | W 14-3 | 52-36 | 2 | 55,019 | Mike Mussina | Mark Buehrle | Mike Mussina | Mark Buehrle | | 499 | 414 | 85 |
| 2006-07-16 | vs CHA | 89 | W 6-4 | 53-36 | 2 | 54,781 | Jaret Wright | Freddy Garcia | Jaret Wright | Freddy Garcia | Mariano Rivera | 505 | 418 | 87 |
| 2006-07-17 | vs SEA | 90 | W 4-2 | 54-36 | 2 | 53,444 | Chien-Ming Wang | Jarrod Washburn | Chien-Ming Wang | Jarrod Washburn | Mariano Rivera | 509 | 420 | 89 |
| 2006-07-18 | vs SEA | 91 | W 5-4 | 55-36 | 2 | 52,992 | Sidney Ponson | Joel Pineiro | Scott Proctor | Julio Mateo | | 514 | 424 | 90 |
| 2006-07-19 | vs SEA | 92 | L 2-3 | 55-37 | 2 | 54,121 | Randy Johnson | Gil Meche | Mark Lowe | Randy Johnson | J.J. Putz | 516 | 427 | 89 |
| 2006-07-20 | @ TOR | 93 | L 4-5 | 55-38 | 2 | 42,336 | Mike Mussina | Roy Halladay | Brian Tallet | Mariano Rivera | | 520 | 432 | 88 |
| 2006-07-21 | @ TOR | 94 | L 3-7 | 55-39 | 2 | 40,149 | Jaret Wright | A.J. Burnett | A.J. Burnett | Jaret Wright | Scott Schoeneweis | 523 | 439 | 84 |
| 2006-07-22 | @ TOR | 95 | W 5-4 | 56-39 | 2 | 50,014 | Chien-Ming Wang | Ted Lilly | Chien-Ming Wang | Scott Downs | Mariano Rivera | 528 | 443 | 85 |
| 2006-07-23 | @ TOR | 96 | L 5-13 | 56-40 | 2 | 42,337 | Sidney Ponson | Shaun Marcum | Shaun Marcum | Sidney Ponson | | 533 | 456 | 77 |
| 2006-07-24 | @ TEX | 97 | W 6-2 | 57-40 | 2 | 43,206 | Randy Johnson | Kevin Millwood | Randy Johnson | Kevin Millwood | | 539 | 458 | 81 |
| 2006-07-25 | @ TEX | 98 | W 7-4 | 58-40 | 2 | 42,171 | Mike Mussina | Adam Eaton | Mike Mussina | Adam Eaton | Mariano Rivera | 546 | 462 | 84 |
| 2006-07-26 | @ TEX | 99 | W 8-7 | 59-40 | 2 | 43,527 | Jaret Wright | John Rheinecker | Shawn Chacon | Akinori Otsuka | Mariano Rivera | 554 | 469 | 85 |
| 2006-07-28 | vs TBA | 100 | W 6-0 | 60-40 | 2 | 53,979 | Chien-Ming Wang | Tim Corcoran | Chien-Ming Wang | Tim Corcoran | | 560 | 469 | 91 |
| 2006-07-29 | vs TBA | 101 | L 6-19 | 60-41 | 2 | 54,485 | Randy Johnson | Jae Weong Seo | Jae Weong Seo | Randy Johnson | | 566 | 488 | 78 |
| 2006-07-30 | vs TBA | 102 | W 4-2 | 61-41 | 2 | 54,012 | Mike Mussina | James Shields | Mike Mussina | James Shields | Mariano Rivera | 570 | 490 | 80 |
| 2006-08-01 | vs TOR | 103 | W 5-1 | 62-41 | 1 | 52,237 | Jaret Wright | A.J. Burnett | Jaret Wright | A.J. Burnett | | 575 | 491 | 84 |
| 2006-08-02 | vs TOR | 104 | W 7-2 | 63-41 | 1 | 54,414 | Chien-Ming Wang | Ted Lilly | Chien-Ming Wang | Ted Lilly | | 582 | 493 | 89 |
| 2006-08-03 | vs TOR | 105 | W 8-1 | 64-41 | 1 | 52,156 | Cory Lidle | Shaun Marcum | Cory Lidle | Shaun Marcum | | 590 | 494 | 96 |
| 2006-08-04 | @ BAL | 106 | W 5-4 | 65-41 | 1 | 44,840 | Randy Johnson | Bruce Chen | Scott Proctor | Chris Ray | Mariano Rivera | 595 | 498 | 97 |
| 2006-08-05 | @ BAL | 107 | L 0-5 | 65-42 | 1 | 49,159 | Mike Mussina | Adam Loewen | Adam Loewen | Mike Mussina | | 595 | 503 | 92 |
| 2006-08-06 | @ BAL | 108 | W 6-1 | 66-42 | 1 | 45,693 | Jaret Wright | Rodrigo Lopez | Jaret Wright | Rodrigo Lopez | Mariano Rivera | 601 | 504 | 97 |
| 2006-08-08 | @ CHA | 109 | L 5-6 | 66-43 | 1 | 39,872 | Chien-Ming Wang | Freddy Garcia | Bobby Jenks | Scott Proctor | | 606 | 510 | 96 |
| 2006-08-09 | @ CHA | 110 | W 7-6 | 67-43 | 1 | 39,406 | Randy Johnson | Jon Garland | Randy Johnson | Jon Garland | Mariano Rivera | 613 | 516 | 97 |
| 2006-08-10 | @ CHA | 111 | L 4-5 | 67-44 | 1 | 39,289 | Mike Mussina | Javier Vazquez | Javier Vazquez | Mike Mussina | Bobby Jenks | 617 | 521 | 96 |
| 2006-08-11 | vs ANA | 112 | L 4-7 | 67-45 | 1 | 54,450 | Cory Lidle | Joe Saunders | Joe Saunders | Cory Lidle | Francisco Rodriguez | 621 | 528 | 93 |
| 2006-08-12 | vs ANA | 113 | W 5-2 | 68-45 | 1 | 54,157 | Jaret Wright | Kelvim Escobar | Jaret Wright | Kelvim Escobar | Mariano Rivera | 626 | 530 | 96 |
| 2006-08-13 | vs ANA | 114 | L 3-5 | 68-46 | 1 | 54,309 | Chien-Ming Wang | Jered Weaver | Jered Weaver | Chien-Ming Wang | Francisco Rodriguez | 629 | 535 | 94 |
| 2006-08-14 | vs ANA | 115 | W 7-2 | 69-46 | 1 | 52,100 | Randy Johnson | John Lackey | Randy Johnson | John Lackey | | 636 | 537 | 99 |
| 2006-08-15 | vs BAL | 116 | W 6-3 | 70-46 | 1 | 52,418 | Mike Mussina | Erik Bedard | Scott Proctor | LaTroy Hawkins | Mariano Rivera | 642 | 540 | 102 |
| 2006-08-16 | vs BAL | 117 | L 2-3 | 70-47 | 1 | 54,244 | Cory Lidle | Adam Loewen | Adam Loewen | Cory Lidle | Chris Ray | 644 | 543 | 101 |
| 2006-08-17 | vs BAL | 118 | L 2-12 | 70-48 | 1 | 54,333 | Jaret Wright | Rodrigo Lopez | Rodrigo Lopez | Jaret Wright | | 646 | 555 | 91 |
| 2006-08-18 | @ BOS | 119 | W 12-4 | 72-48 | 1 | 36,325 | Chien-Ming Wang | Jason Johnson | Chien-Ming Wang | Jason Johnson | | 658 | 559 | 99 |
| 2006-08-18 | @ BOS | 120 | W 14-11 | 72-48 | 1 | 36,071 | Sidney Ponson | Jon Lester | Mike Myers | Mike Timlin | | 672 | 570 | 102 |
| 2006-08-19 | @ BOS | 121 | W 13-5 | 73-48 | 1 | 35,738 | Randy Johnson | Josh Beckett | Randy Johnson | Josh Beckett | | 685 | 575 | 110 |
| 2006-08-20 | @ BOS | 122 | W 8-5 | 74-48 | 1 | 36,155 | Mike Mussina | Curt Schilling | Mariano Rivera | Craig Hansen | | 693 | 580 | 113 |
| 2006-08-21 | @ BOS | 123 | W 2-1 | 75-48 | 1 | 35,829 | Cory Lidle | David Wells | Cory Lidle | David Wells | Kyle Farnsworth | 695 | 581 | 114 |
| 2006-08-22 | @ SEA | 124 | L 5-6 | 75-49 | 1 | 42,454 | Jeff Karstens | Cha-Seung Baek | Julio Mateo | Ron Villone | | 700 | 587 | 113 |
| 2006-08-23 | @ SEA | 125 | W 9-2 | 76-49 | 1 | 41,380 | Chien-Ming Wang | Felix Hernandez | Chien-Ming Wang | Felix Hernandez | | 709 | 589 | 120 |
| 2006-08-24 | @ SEA | 126 | L 2-4 | 76-50 | 1 | 44,634 | Randy Johnson | Jarrod Washburn | Jarrod Washburn | Randy Johnson | J.J. Putz | 711 | 593 | 118 |
| 2006-08-25 | @ ANA | 127 | L 5-6 | 76-51 | 1 | 44,253 | Jaret Wright | John Lackey | Francisco Rodriguez | Mike Myers | | 716 | 599 | 117 |
| 2006-08-26 | @ ANA | 128 | L 7-12 | 76-52 | 1 | 44,185 | Cory Lidle | Ervin Santana | Ervin Santana | Brian Bruney | Francisco Rodriguez | 723 | 611 | 112 |
| 2006-08-27 | @ ANA | 129 | W 11-8 | 77-52 | 1 | 44,225 | Jeff Karstens | Joe Saunders | Jeff Karstens | Joe Saunders | | 734 | 619 | 115 |
| 2006-08-30 | vs DET | 130 | W 2-0 | 78-53 | 1 | 52,585 | Chien-Ming Wang | Nate Robertson | Chien-Ming Wang | Nate Robertson | Mariano Rivera | 736 | 619 | 117 |
| 2006-08-30 | vs DET | 131 | L 3-5 | 78-53 | 1 | 54,509 | Jaret Wright | Wil Ledezma | Jason Grilli | Scott Proctor | Todd Jones | 739 | 624 | 115 |
| 2006-08-31 | vs DET | 132 | W 6-4 | 79-53 | 1 | 54,771 | Randy Johnson | Jeremy Bonderman | Randy Johnson | Jeremy Bonderman | Mariano Rivera | 745 | 628 | 117 |
| 2006-09-01 | vs MIN | 133 | W 8-1 | 80-53 | 1 | 54,311 | Cory Lidle | Carlos Silva | Cory Lidle | Carlos Silva | | 753 | 629 | 124 |
| 2006-09-02 | vs MIN | 134 | L 1-6 | 80-54 | 1 | 53,220 | Jeff Karstens | Scott Baker | Scott Baker | Jeff Karstens | Jesse Crain | 754 | 635 | 119 |
| 2006-09-03 | vs MIN | 135 | W 10-1 | 81-54 | 1 | 55,155 | Darrell Rasner | Matt Garza | Darrell Rasner | Matt Garza | | 764 | 636 | 128 |
| 2006-09-04 | @ KCA | 136 | W 12-5 | 82-54 | 1 | 27,123 | Chien-Ming Wang | Luke Hudson | T.J. Beam | Scott Dohmann | | 776 | 641 | 135 |
| 2006-09-05 | @ KCA | 137 | L 0-5 | 82-55 | 1 | 25,104 | Mike Mussina | Jorge de la Rosa | Jorge de la Rosa | Mike Mussina | Todd Wellemeyer | 776 | 646 | 130 |
| 2006-09-06 | @ KCA | 138 | W 8-3 | 83-55 | 1 | 16,421 | Randy Johnson | Runelvys Hernandez | Randy Johnson | Runelvys Hernandez | | 784 | 649 | 135 |
| 2006-09-08 | @ BAL | 139 | L 4-9 | 83-56 | 1 | 36,214 | Cory Lidle | Erik Bedard | Erik Bedard | Cory Lidle | | 788 | 658 | 130 |
| 2006-09-09 | @ BAL | 140 | W 3-2 | 84-56 | 1 | 45,827 | Chien-Ming Wang | Adam Loewen | Chien-Ming Wang | Adam Loewen | Kyle Farnsworth | 791 | 660 | 131 |
| 2006-09-10 | @ BAL | 141 | W 9-4 | 85-56 | 1 | 40,125 | Jaret Wright | Hayden Penn | Jaret Wright | Hayden Penn | | 800 | 664 | 136 |
| 2006-09-11 | @ BAL | 142 | W 9-6 | 86-56 | 1 | 21,742 | Randy Johnson | Rodrigo Lopez | Randy Johnson | Jim Hoey | Kyle Farnsworth | 809 | 670 | 139 |
| 2006-09-12 | vs TBA | 143 | W 12-4 | 87-56 | 1 | 52,265 | Mike Mussina | Tim Corcoran | Mike Mussina | Tim Corcoran | | 821 | 674 | 147 |
| 2006-09-13 | vs TBA | 144 | W 8-4 | 88-56 | 1 | 52,279 | Cory Lidle | Jason Hammel | Brian Bruney | Jason Hammel | | 829 | 678 | 151 |
| 2006-09-14 | vs TBA | 145 | W 7-4 | 89-56 | 1 | 51,965 | Jeff Karstens | James Shields | Darrell Rasner | Ruddy Lugo | | 836 | 682 | 154 |
| 2006-09-16 | vs BOS | 146 | L 2-5 | 90-57 | 1 | 55,091 | Chien-Ming Wang | Josh Beckett | Josh Beckett | Chien-Ming Wang | Mike Timlin | 838 | 687 | 151 |
| 2006-09-16 | vs BOS | 147 | W 7-5 | 90-57 | 1 | 55,167 | Randy Johnson | Julian Tavarez | Scott Proctor | Craig Breslow | Kyle Farnsworth | 845 | 692 | 153 |
| 2006-09-17 | vs BOS | 148 | L 3-6 | 90-59 | 1 | 55,002 | Jaret Wright | Kyle Snyder | Bryan Corey | Ron Villone | Mike Timlin | 848 | 698 | 150 |
| 2006-09-17 | vs BOS | 149 | L 4-5 | 90-59 | 1 | 55,221 | Mike Mussina | Kevin Jarvis | Javier Lopez | Kyle Farnsworth | Mike Timlin | 852 | 703 | 149 |
| 2006-09-18 | @ TOR | 150 | W 7-6 | 91-59 | 1 | 32,846 | Darrell Rasner | A.J. Burnett | Darrell Rasner | A.J. Burnett | Jose Veras | 859 | 709 | 150 |
| 2006-09-19 | @ TOR | 151 | W 6-3 | 92-59 | 1 | 30,793 | Jeff Karstens | Shaun Marcum | Jeff Karstens | Jason Frasor | Kyle Farnsworth | 865 | 712 | 153 |
| 2006-09-20 | @ TOR | 152 | L 2-3 | 92-60 | 1 | 33,029 | Sean Henn | Roy Halladay | Davis Romero | Sean Henn | B.J. Ryan | 867 | 715 | 152 |
| 2006-09-22 | @ TBA | 153 | W 4-1 | 93-60 | 1 | 26,337 | Chien-Ming Wang | James Shields | Chien-Ming Wang | James Shields | Mariano Rivera | 871 | 716 | 155 |
| 2006-09-23 | @ TBA | 154 | L 0-8 | 93-61 | 1 | 33,492 | Randy Johnson | J.P. Howell | J.P. Howell | Randy Johnson | | 871 | 724 | 147 |
| 2006-09-24 | @ TBA | 155 | L 4-11 | 93-62 | 1 | 31,422 | Mike Mussina | Brian Stokes | Brian Stokes | Mike Mussina | | 875 | 735 | 140 |
| 2006-09-25 | @ TBA | 156 | W 16-1 | 94-62 | 1 | 24,053 | Jaret Wright | Jae Weong Seo | Jaret Wright | Jae Weong Seo | | 891 | 736 | 155 |
| 2006-09-26 | vs BAL | 157 | W 5-4 | 95-62 | 1 | 53,420 | Cory Lidle | Hayden Penn | Cory Lidle | Rodrigo Lopez | Scott Proctor | 896 | 740 | 156 |
| 2006-09-27 | vs BAL | 158 | W 16-5 | 96-62 | 1 | 53,040 | Chien-Ming Wang | Kris Benson | Chien-Ming Wang | Kris Benson | | 912 | 745 | 167 |
| 2006-09-28 | vs BAL | 159 | L 1-7 | 96-63 | 1 | 54,046 | Darrell Rasner | Daniel Cabrera | Daniel Cabrera | Darrell Rasner | | 913 | 752 | 161 |
| 2006-09-29 | vs TOR | 160 | W 7-2 | 97-63 | 1 | 52,331 | Mike Mussina | Gustavo Chacin | Mike Mussina | Gustavo Chacin | | 920 | 754 | 166 |
| 2006-09-30 | vs TOR | 161 | L 5-6 | 97-64 | 1 | 54,576 | Jeff Karstens | Shaun Marcum | Jason Frasor | Mike Myers | B.J. Ryan | 925 | 760 | 165 |
| 2006-10-01 | vs TOR | 162 | L 5-7 | 97-65 | 1 | 54,886 | Jaret Wright | Dustin McGowan | Josh Towers | Kyle Farnsworth | Scott Downs | 930 | 767 | 163 |