| 2006-04-03 | vs DET | 1 | L 1-3 | 0-1 | 4 | 41,054 | Scott Elarton | Kenny Rogers | Kenny Rogers | Scott Elarton | Fernando Rodney | 1 | 3 | -2 |
| 2006-04-05 | vs DET | 2 | L 3-14 | 0-2 | 5 | 11,265 | Joe Mays | Jeremy Bonderman | Jeremy Bonderman | Joe Mays | | 4 | 17 | -13 |
| 2006-04-07 | vs CHA | 3 | W 11-7 | 1-2 | 3 | 23,204 | Jeremy Affeldt | Jon Garland | Mike Wood | Jon Garland | | 15 | 24 | -9 |
| 2006-04-08 | vs CHA | 4 | W 4-3 | 2-2 | 3 | 18,031 | Denny Bautista | Javier Vazquez | Elmer Dessens | Cliff Politte | Ambiorix Burgos | 19 | 27 | -8 |
| 2006-04-09 | vs CHA | 5 | L 1-3 | 2-3 | 3 | 15,094 | Scott Elarton | Mark Buehrle | Mark Buehrle | Scott Elarton | Bobby Jenks | 20 | 30 | -10 |
| 2006-04-11 | @ NYA | 6 | L 7-9 | 2-4 | 4 | 54,698 | Joe Mays | Chien-Ming Wang | Scott Proctor | Andy Sisco | Mariano Rivera | 27 | 39 | -12 |
| 2006-04-12 | @ NYA | 7 | L 5-12 | 2-5 | 5 | 41,448 | Jeremy Affeldt | Shawn Chacon | Shawn Chacon | Jeremy Affeldt | | 32 | 51 | -19 |
| 2006-04-13 | @ NYA | 8 | L 3-9 | 2-6 | 5 | 54,381 | Denny Bautista | Randy Johnson | Randy Johnson | Denny Bautista | | 35 | 60 | -25 |
| 2006-04-14 | @ TBA | 9 | L 2-7 | 2-7 | 5 | 12,092 | Scott Elarton | Scott Kazmir | Travis Harper | Scott Elarton | | 37 | 67 | -30 |
| 2006-04-15 | @ TBA | 10 | L 3-6 | 2-8 | 5 | 20,002 | Mike Wood | Seth McClung | Seth McClung | Luke Hudson | Shawn Camp | 40 | 73 | -33 |
| 2006-04-16 | @ TBA | 11 | L 5-9 | 2-9 | 5 | 11,853 | Mark Redman | Jason Hammel | Brian Meadows | Steve Stemle | | 45 | 82 | -37 |
| 2006-04-17 | @ CHA | 12 | L 0-9 | 2-10 | 5 | 27,889 | Joe Mays | Jose Contreras | Jose Contreras | Joe Mays | | 45 | 91 | -46 |
| 2006-04-18 | @ CHA | 13 | L 1-4 | 2-11 | 5 | 21,901 | Jeremy Affeldt | Jon Garland | Jon Garland | Jeremy Affeldt | Bobby Jenks | 46 | 95 | -49 |
| 2006-04-19 | @ CHA | 14 | L 0-4 | 2-12 | 5 | 26,327 | Scott Elarton | Javier Vazquez | Javier Vazquez | Scott Elarton | Bobby Jenks | 46 | 99 | -53 |
| 2006-04-21 | vs CLE | 15 | L 5-6 | 2-13 | 5 | 16,791 | Mark Redman | Cliff Lee | Danny Graves | Elmer Dessens | Bob Wickman | 51 | 105 | -54 |
| 2006-04-22 | vs CLE | 16 | W 11-5 | 3-13 | 5 | 19,645 | Joe Mays | Paul Byrd | Mike Wood | Paul Byrd | | 62 | 110 | -48 |
| 2006-04-23 | vs CLE | 17 | W 5-1 | 4-13 | 5 | 12,194 | Jeremy Affeldt | Jason Johnson | Jeremy Affeldt | Jason Johnson | | 67 | 111 | -44 |
| 2006-04-25 | vs MIN | 18 | L 1-2 | 4-14 | 5 | 12,911 | Scott Elarton | Kyle Lohse | Francisco Liriano | Luke Hudson | Joe Nathan | 68 | 113 | -45 |
| 2006-04-26 | vs MIN | 19 | W 3-1 | 5-14 | 5 | 9,188 | Runelvys Hernandez | Scott Baker | Runelvys Hernandez | Scott Baker | Ambiorix Burgos | 71 | 114 | -43 |
| 2006-04-27 | vs MIN | 20 | L 3-7 | 5-15 | 5 | 11,391 | Mark Redman | Johan Santana | Johan Santana | Mark Redman | | 74 | 121 | -47 |
| 2006-04-28 | vs OAK | 21 | L 3-5 | 5-16 | 5 | 12,203 | Joe Mays | Dan Haren | Dan Haren | Joe Mays | Kirk Saarloos | 77 | 126 | -49 |
| 2006-04-30 | vs OAK | 22 | L 6-13 | 5-17 | 5 | 15,224 | Scott Elarton | Joe Blanton | Joe Blanton | Luke Hudson | | 83 | 139 | -56 |
| 2006-05-01 | @ DET | 23 | L 2-3 | 5-18 | 5 | 9,597 | Runelvys Hernandez | Jeremy Bonderman | Jeremy Bonderman | Runelvys Hernandez | Todd Jones | 85 | 142 | -57 |
| 2006-05-02 | @ DET | 24 | L 1-4 | 5-19 | 5 | 12,415 | Mark Redman | Mike Maroth | Mike Maroth | Mark Redman | Todd Jones | 86 | 146 | -60 |
| 2006-05-03 | @ MIN | 25 | L 1-6 | 5-20 | 5 | 15,996 | Joe Mays | Brad Radke | Brad Radke | Joe Mays | | 87 | 152 | -65 |
| 2006-05-04 | @ MIN | 26 | W 1-0 | 6-20 | 5 | 11,803 | Jeremy Affeldt | Carlos Silva | Jeremy Affeldt | Carlos Silva | Ambiorix Burgos | 88 | 152 | -64 |
| 2006-05-05 | @ CHA | 27 | W 5-4 | 6-21 | 5 | 33,628 | Scott Elarton | Jon Garland | Elmer Dessens | Bobby Jenks | Ambiorix Burgos | 93 | 156 | -63 |
| 2006-05-06 | @ CHA | 28 | L 2-9 | 6-22 | 5 | 38,593 | Runelvys Hernandez | Javier Vazquez | Javier Vazquez | Runelvys Hernandez | | 95 | 165 | -70 |
| 2006-05-07 | @ CHA | 29 | L 2-3 | 6-23 | 5 | 38,870 | Mark Redman | Mark Buehrle | Brandon McCarthy | Elmer Dessens | Bobby Jenks | 97 | 168 | -71 |
| 2006-05-08 | vs CLE | 30 | W 4-3 | 7-23 | 5 | 9,029 | Denny Bautista | Paul Byrd | Mike Wood | Paul Byrd | Ambiorix Burgos | 101 | 171 | -70 |
| 2006-05-09 | vs CLE | 31 | W 10-7 | 8-23 | 5 | 14,784 | Jeremy Affeldt | Jason Johnson | Joel Peralta | Danny Graves | | 111 | 178 | -67 |
| 2006-05-10 | vs CLE | 32 | W 10-8 | 9-23 | 5 | 24,471 | Scott Elarton | Jake Westbrook | Ambiorix Burgos | Guillermo Mota | | 121 | 186 | -65 |
| 2006-05-12 | @ BAL | 33 | L 5-6 | 9-24 | 5 | 30,848 | Runelvys Hernandez | Erik Bedard | Todd Williams | Elmer Dessens | Chris Ray | 126 | 192 | -66 |
| 2006-05-13 | @ BAL | 34 | L 1-11 | 9-25 | 5 | 33,188 | Mark Redman | Kris Benson | Kris Benson | Mark Redman | | 127 | 203 | -76 |
| 2006-05-14 | @ BAL | 35 | L 7-8 | 9-26 | 5 | 25,530 | Denny Bautista | Daniel Cabrera | John Halama | Ambiorix Burgos | | 134 | 211 | -77 |
| 2006-05-16 | @ CLE | 36 | L 4-6 | 9-27 | 5 | 15,399 | Scott Elarton | Paul Byrd | Jason Davis | Ambiorix Burgos | | 138 | 217 | -79 |
| 2006-05-17 | @ CLE | 37 | L 0-5 | 9-28 | 5 | 15,064 | Jeremy Affeldt | Jake Westbrook | Jake Westbrook | Jeremy Affeldt | | 138 | 222 | -84 |
| 2006-05-18 | @ CLE | 38 | L 5-6 | 9-29 | 5 | 24,184 | Runelvys Hernandez | Cliff Lee | Cliff Lee | Runelvys Hernandez | Bob Wickman | 143 | 228 | -85 |
| 2006-05-19 | vs SLN | 39 | L 6-9 | 9-30 | 5 | 33,045 | Mark Redman | Chris Carpenter | Chris Carpenter | Mark Redman | Adam Wainwright | 149 | 237 | -88 |
| 2006-05-20 | vs SLN | 40 | L 2-4 | 9-31 | 5 | 40,516 | Denny Bautista | Anthony Reyes | Anthony Reyes | Denny Bautista | Jason Isringhausen | 151 | 241 | -90 |
| 2006-05-21 | vs SLN | 41 | L 3-10 | 9-32 | 5 | 30,266 | Scott Elarton | Jeff Suppan | Jeff Suppan | Scott Elarton | | 154 | 251 | -97 |
| 2006-05-22 | vs DET | 42 | L 0-8 | 9-33 | 5 | 9,746 | Jeremy Affeldt | Justin Verlander | Justin Verlander | Jeremy Affeldt | | 154 | 259 | -105 |
| 2006-05-23 | vs DET | 43 | L 5-8 | 9-34 | 5 | 15,556 | Runelvys Hernandez | Kenny Rogers | Joel Zumaya | Elmer Dessens | Todd Jones | 159 | 267 | -108 |
| 2006-05-24 | vs DET | 44 | L 3-6 | 9-35 | 5 | 10,745 | Jimmy Gobble | Jeremy Bonderman | Jeremy Bonderman | Jimmy Gobble | Todd Jones | 162 | 273 | -111 |
| 2006-05-25 | vs DET | 45 | L 8-13 | 9-36 | 5 | 11,488 | Denny Bautista | Mike Maroth | Joel Zumaya | Elmer Dessens | | 170 | 286 | -116 |
| 2006-05-26 | @ NYA | 46 | W 7-6 | 10-36 | 5 | 48,035 | Scott Elarton | Mike Mussina | Scott Elarton | Kyle Farnsworth | Andy Sisco | 177 | 292 | -115 |
| 2006-05-27 | @ NYA | 47 | L 4-15 | 10-37 | 5 | 54,216 | Jeremy Affeldt | Chien-Ming Wang | Chien-Ming Wang | Jeremy Affeldt | | 181 | 307 | -126 |
| 2006-05-28 | @ NYA | 48 | L 5-6 | 10-38 | 5 | 54,372 | Runelvys Hernandez | Jaret Wright | Jaret Wright | Runelvys Hernandez | Mariano Rivera | 186 | 313 | -127 |
| 2006-05-29 | @ OAK | 49 | W 6-4 | 11-38 | 5 | 28,040 | Seth Etherton | Dan Haren | Seth Etherton | Dan Haren | Ambiorix Burgos | 192 | 317 | -125 |
| 2006-05-30 | @ OAK | 50 | W 8-7 | 12-38 | 5 | 12,516 | Denny Bautista | Brad Halsey | Elmer Dessens | Matt Roney | Ambiorix Burgos | 200 | 324 | -124 |
| 2006-05-31 | @ OAK | 51 | L 0-7 | 12-39 | 5 | 25,181 | Scott Elarton | Joe Blanton | Joe Blanton | Scott Elarton | | 200 | 331 | -131 |
| 2006-06-02 | @ SEA | 52 | L 0-4 | 12-40 | 5 | 28,382 | Bobby Keppel | Jamie Moyer | Jamie Moyer | Bobby Keppel | | 200 | 335 | -135 |
| 2006-06-03 | @ SEA | 53 | L 1-12 | 12-41 | 5 | 29,659 | Seth Etherton | Joel Pineiro | Joel Pineiro | Seth Etherton | | 201 | 347 | -146 |
| 2006-06-04 | @ SEA | 54 | W 9-4 | 13-41 | 5 | 28,886 | Mark Redman | Jarrod Washburn | Mark Redman | Jarrod Washburn | Elmer Dessens | 210 | 351 | -141 |
| 2006-06-05 | @ SEA | 55 | L 1-4 | 13-42 | 5 | 18,409 | Mike Wood | Gil Meche | Gil Meche | Mike Wood | J.J. Putz | 211 | 355 | -144 |
| 2006-06-06 | vs TEX | 56 | L 2-6 | 13-43 | 5 | 11,715 | Scott Elarton | Kevin Millwood | Kevin Millwood | Scott Elarton | Francisco Cordero | 213 | 361 | -148 |
| 2006-06-07 | vs TEX | 57 | L 2-4 | 13-44 | 5 | 11,246 | Bobby Keppel | John Koronka | Akinori Otsuka | Ambiorix Burgos | Francisco Cordero | 215 | 365 | -150 |
| 2006-06-08 | vs TEX | 58 | W 16-12 | 14-44 | 5 | 11,815 | Kyle Snyder | Kameron Loe | Jimmy Gobble | Ron Mahay | | 231 | 377 | -146 |
| 2006-06-09 | vs TBA | 59 | W 4-2 | 15-44 | 5 | 26,508 | Mark Redman | Mark Hendrickson | Mark Redman | Mark Hendrickson | Ambiorix Burgos | 235 | 379 | -144 |
| 2006-06-10 | vs TBA | 60 | L 5-9 | 15-45 | 5 | 12,929 | Mike Wood | Casey Fossum | Casey Fossum | Mike Wood | | 240 | 388 | -148 |
| 2006-06-11 | vs TBA | 61 | L 2-8 | 15-46 | 5 | 17,792 | Scott Elarton | James Shields | James Shields | Scott Elarton | | 242 | 396 | -154 |
| 2006-06-12 | @ ANA | 62 | L 3-4 | 15-47 | 5 | 36,146 | Bobby Keppel | Ervin Santana | Ervin Santana | Bobby Keppel | Francisco Rodriguez | 245 | 400 | -155 |
| 2006-06-13 | @ ANA | 63 | L 1-4 | 15-48 | 5 | 38,820 | Brandon Duckworth | Jered Weaver | Jered Weaver | Brandon Duckworth | Francisco Rodriguez | 246 | 404 | -158 |
| 2006-06-14 | @ ANA | 64 | W 4-3 | 16-48 | 5 | 38,910 | Mark Redman | Kelvim Escobar | Mark Redman | Scot Shields | Ambiorix Burgos | 250 | 407 | -157 |
| 2006-06-15 | @ ANA | 65 | L 2-3 | 16-49 | 5 | 41,649 | Mike Wood | John Lackey | Hector Carrasco | Elmer Dessens | | 252 | 410 | -158 |
| 2006-06-16 | @ HOU | 66 | W 7-2 | 17-49 | 5 | 36,328 | Scott Elarton | Wandy Rodriguez | Scott Elarton | Wandy Rodriguez | | 259 | 412 | -153 |
| 2006-06-17 | @ HOU | 67 | L 2-7 | 17-50 | 5 | 39,048 | Bobby Keppel | Taylor Buchholz | Taylor Buchholz | Bobby Keppel | | 261 | 419 | -158 |
| 2006-06-18 | @ HOU | 68 | W 7-4 | 18-50 | 5 | 39,867 | Brandon Duckworth | Andy Pettitte | Jimmy Gobble | Chad Qualls | Ambiorix Burgos | 268 | 423 | -155 |
| 2006-06-20 | vs PIT | 69 | W 10-6 | 19-50 | 5 | 15,906 | Mark Redman | Kip Wells | Mark Redman | Kip Wells | | 278 | 429 | -151 |
| 2006-06-21 | vs PIT | 70 | W 6-4 | 20-50 | 5 | 15,501 | Mike Wood | Ian Snell | Elmer Dessens | Salomon Torres | Ambiorix Burgos | 284 | 433 | -149 |
| 2006-06-22 | vs PIT | 71 | W 15-7 | 21-50 | 5 | 13,153 | Scott Elarton | Paul Maholm | Scott Elarton | Paul Maholm | | 299 | 440 | -141 |
| 2006-06-23 | vs MIL | 72 | L 2-7 | 21-51 | 5 | 18,112 | Bobby Keppel | David Bush | David Bush | Bobby Keppel | | 301 | 447 | -146 |
| 2006-06-24 | vs MIL | 73 | W 6-5 | 22-51 | 5 | 20,464 | Brandon Duckworth | Doug Davis | Brandon Duckworth | Doug Davis | Ambiorix Burgos | 307 | 452 | -145 |
| 2006-06-25 | vs MIL | 74 | W 6-0 | 23-51 | 5 | 14,726 | Mark Redman | Rick Helling | Mark Redman | Rick Helling | Jimmy Gobble | 313 | 452 | -139 |
| 2006-06-27 | @ CIN | 75 | W 9-8 | 24-51 | 5 | 21,420 | Mike Wood | Eric Milton | Jeremy Affeldt | Todd Coffey | Ambiorix Burgos | 322 | 460 | -138 |
| 2006-06-28 | @ CIN | 76 | L 2-7 | 24-52 | 5 | 34,648 | Scott Elarton | Aaron Harang | Aaron Harang | Scott Elarton | | 324 | 467 | -143 |
| 2006-06-29 | @ CIN | 77 | L 5-6 | 24-53 | 5 | 22,093 | Bobby Keppel | Bronson Arroyo | David Weathers | Elmer Dessens | Todd Coffey | 329 | 473 | -144 |
| 2006-06-30 | @ SLN | 78 | W 7-5 | 25-53 | 5 | 45,884 | Brandon Duckworth | Jeff Suppan | Ambiorix Burgos | Braden Looper | | 336 | 478 | -142 |
| 2006-07-01 | @ SLN | 79 | W 8-7 | 26-53 | 5 | 45,035 | Mark Redman | Sidney Ponson | Luke Hudson | Jason Isringhausen | | 344 | 485 | -141 |
| 2006-07-02 | @ SLN | 80 | L 7-9 | 26-54 | 5 | 45,400 | Mike Wood | Jason Marquis | Jason Marquis | Mike Wood | | 351 | 494 | -143 |
| 2006-07-03 | vs MIN | 81 | L 5-6 | 26-55 | 5 | 28,401 | Scott Elarton | Johan Santana | Jesse Crain | Andy Sisco | Joe Nathan | 356 | 500 | -144 |
| 2006-07-04 | vs MIN | 82 | W 7-2 | 27-55 | 5 | 23,996 | Jimmy Gobble | Boof Bonser | Jimmy Gobble | Boof Bonser | Elmer Dessens | 363 | 502 | -139 |
| 2006-07-05 | vs MIN | 83 | W 6-3 | 28-55 | 5 | 12,085 | Brandon Duckworth | Brad Radke | Jeremy Affeldt | Jesse Crain | Ambiorix Burgos | 369 | 505 | -136 |
| 2006-07-06 | vs TOR | 84 | W 6-2 | 29-55 | 5 | 10,858 | Mark Redman | Ty Taubenheim | Mark Redman | Ty Taubenheim | | 375 | 507 | -132 |
| 2006-07-07 | vs TOR | 85 | W 13-3 | 30-55 | 5 | 17,162 | Luke Hudson | A.J. Burnett | Luke Hudson | A.J. Burnett | | 388 | 510 | -122 |
| 2006-07-08 | vs TOR | 86 | L 5-7 | 30-56 | 5 | 22,635 | Scott Elarton | Ted Lilly | Brian Tallet | Joel Peralta | B.J. Ryan | 393 | 517 | -124 |
| 2006-07-09 | vs TOR | 87 | L 3-11 | 30-57 | 5 | 17,748 | Jimmy Gobble | Roy Halladay | Roy Halladay | Jimmy Gobble | | 396 | 528 | -132 |
| 2006-07-13 | @ DET | 88 | L 4-6 | 30-58 | 5 | 31,967 | Brandon Duckworth | Jeremy Bonderman | Jeremy Bonderman | Brandon Duckworth | Todd Jones | 400 | 534 | -134 |
| 2006-07-14 | @ DET | 89 | L 9-10 | 30-59 | 5 | 38,442 | Mark Redman | Kenny Rogers | Todd Jones | Jeremy Affeldt | | 409 | 544 | -135 |
| 2006-07-15 | @ DET | 90 | L 0-6 | 30-60 | 5 | 40,210 | Jimmy Gobble | Justin Verlander | Justin Verlander | Jimmy Gobble | | 409 | 550 | -141 |
| 2006-07-16 | @ DET | 91 | W 9-6 | 31-60 | 5 | 37,893 | Scott Elarton | Zach Miner | Scott Elarton | Zach Miner | Mike MacDougal | 418 | 556 | -138 |
| 2006-07-17 | @ BOS | 92 | L 4-5 | 31-61 | 5 | 36,436 | Luke Hudson | Tim Wakefield | Mike Timlin | Joel Peralta | Jonathan Papelbon | 422 | 561 | -139 |
| 2006-07-18 | @ BOS | 93 | L 0-1 | 31-62 | 5 | 36,224 | Brandon Duckworth | Jon Lester | Jon Lester | Brandon Duckworth | Jonathan Papelbon | 422 | 562 | -140 |
| 2006-07-19 | @ BOS | 94 | L 0-1 | 31-63 | 5 | 36,098 | Mark Redman | Josh Beckett | Josh Beckett | Mark Redman | Jonathan Papelbon | 422 | 563 | -141 |
| 2006-07-20 | vs ANA | 95 | W 9-4 | 32-63 | 5 | 12,178 | Jimmy Gobble | Ervin Santana | Elmer Dessens | Kevin Gregg | | 431 | 567 | -136 |
| 2006-07-21 | vs ANA | 96 | W 8-3 | 33-63 | 5 | 20,988 | Runelvys Hernandez | Bartolo Colon | Runelvys Hernandez | Bartolo Colon | | 439 | 570 | -131 |
| 2006-07-22 | vs ANA | 97 | L 3-4 | 33-64 | 5 | 26,873 | Luke Hudson | Kelvim Escobar | Scot Shields | Todd Wellemeyer | Francisco Rodriguez | 442 | 574 | -132 |
| 2006-07-23 | vs ANA | 98 | L 1-3 | 33-65 | 5 | 17,496 | Brandon Duckworth | Jered Weaver | Jered Weaver | Brandon Duckworth | Francisco Rodriguez | 443 | 577 | -134 |
| 2006-07-25 | vs BAL | 99 | W 7-5 | 34-65 | 5 | 18,591 | Mark Redman | Kris Benson | Mark Redman | Kurt Birkins | Ambiorix Burgos | 450 | 582 | -132 |
| 2006-07-26 | vs BAL | 100 | L 3-4 | 34-66 | 5 | 11,006 | Runelvys Hernandez | Adam Loewen | Adam Loewen | Runelvys Hernandez | Chris Ray | 453 | 586 | -133 |
| 2006-07-27 | vs BAL | 101 | L 4-6 | 34-67 | 5 | 11,418 | Jimmy Gobble | Rodrigo Lopez | Rodrigo Lopez | Brandon Duckworth | Chris Ray | 457 | 592 | -135 |
| 2006-07-28 | @ TEX | 102 | W 11-3 | 35-67 | 5 | 30,202 | Luke Hudson | Vicente Padilla | Luke Hudson | Vicente Padilla | | 468 | 595 | -127 |
| 2006-07-29 | @ TEX | 103 | W 5-3 | 36-67 | 5 | 42,017 | Jorge de la Rosa | Kevin Millwood | Jorge de la Rosa | Kevin Millwood | Ambiorix Burgos | 473 | 598 | -125 |
| 2006-07-30 | @ TEX | 104 | L 2-15 | 36-68 | 5 | 29,726 | Mark Redman | John Koronka | John Koronka | Mark Redman | | 475 | 613 | -138 |
| 2006-07-31 | vs CHA | 105 | L 4-8 | 36-69 | 5 | 12,903 | Runelvys Hernandez | Jose Contreras | Jose Contreras | Runelvys Hernandez | | 479 | 621 | -142 |
| 2006-08-01 | vs CHA | 106 | L 5-7 | 36-70 | 5 | 11,609 | Odalis Perez | Mark Buehrle | David Riske | Ambiorix Burgos | Bobby Jenks | 484 | 628 | -144 |
| 2006-08-02 | vs CHA | 107 | W 7-3 | 37-70 | 5 | 10,901 | Luke Hudson | Freddy Garcia | Luke Hudson | Freddy Garcia | | 491 | 631 | -140 |
| 2006-08-03 | vs MIN | 108 | L 2-8 | 37-71 | 5 | 12,022 | Jorge de la Rosa | Brad Radke | Brad Radke | Jorge de la Rosa | | 493 | 639 | -146 |
| 2006-08-04 | vs MIN | 109 | L 5-8 | 37-72 | 5 | 19,394 | Mark Redman | Johan Santana | Dennys Reyes | Scott Dohmann | Joe Nathan | 498 | 647 | -149 |
| 2006-08-05 | vs MIN | 110 | L 3-14 | 37-73 | 5 | 25,131 | Runelvys Hernandez | Carlos Silva | Carlos Silva | Runelvys Hernandez | | 501 | 661 | -160 |
| 2006-08-06 | vs MIN | 111 | L 5-11 | 37-74 | 5 | 14,064 | Odalis Perez | Michael Smith | Dennys Reyes | Todd Wellemeyer | | 506 | 672 | -166 |
| 2006-08-08 | vs BOS | 112 | W 6-4 | 38-74 | 5 | 26,687 | Luke Hudson | Jon Lester | Luke Hudson | Jon Lester | Ambiorix Burgos | 512 | 676 | -164 |
| 2006-08-09 | vs BOS | 113 | W 5-4 | 39-74 | 5 | 21,928 | Mark Redman | Josh Beckett | Scott Dohmann | Jonathan Papelbon | | 517 | 680 | -163 |
| 2006-08-10 | vs BOS | 114 | W 5-4 | 40-74 | 5 | 21,214 | Runelvys Hernandez | Curt Schilling | Andy Sisco | Curt Schilling | Ambiorix Burgos | 522 | 684 | -162 |
| 2006-08-11 | @ CLE | 115 | L 3-4 | 40-75 | 5 | 30,929 | Adam Bernero | Paul Byrd | Fernando Cabrera | Ambiorix Burgos | | 525 | 688 | -163 |
| 2006-08-12 | @ CLE | 116 | L 4-5 | 40-77 | 5 | 17,079 | Odalis Perez | CC Sabathia | Rafael Betancourt | Joe Nelson | | 529 | 693 | -164 |
| 2006-08-12 | @ CLE | 117 | L 5-6 | 40-77 | 5 | 28,842 | Jorge de la Rosa | Jeremy Guthrie | Brian Sikorski | Jimmy Gobble | | 534 | 699 | -165 |
| 2006-08-13 | @ CLE | 118 | L 0-13 | 40-78 | 5 | 25,251 | Luke Hudson | Jeremy Sowers | Jeremy Sowers | Luke Hudson | | 534 | 712 | -178 |
| 2006-08-14 | @ CHA | 119 | L 2-12 | 40-79 | 5 | 39,398 | Mark Redman | Jon Garland | Jon Garland | Mark Redman | | 536 | 724 | -188 |
| 2006-08-15 | @ CHA | 120 | W 4-2 | 41-79 | 5 | 35,690 | Runelvys Hernandez | Javier Vazquez | Runelvys Hernandez | Javier Vazquez | Joe Nelson | 540 | 726 | -186 |
| 2006-08-16 | @ CHA | 121 | W 10-4 | 42-79 | 5 | 36,998 | Adam Bernero | Jose Contreras | Adam Bernero | Jose Contreras | | 550 | 730 | -180 |
| 2006-08-17 | @ CHA | 122 | L 4-5 | 42-80 | 5 | 37,839 | Odalis Perez | Mark Buehrle | Mark Buehrle | Odalis Perez | Bobby Jenks | 554 | 735 | -181 |
| 2006-08-18 | vs OAK | 123 | W 7-1 | 44-80 | 5 | 0 | Luke Hudson | Joe Blanton | Luke Hudson | Joe Blanton | | 561 | 736 | -175 |
| 2006-08-18 | vs OAK | 124 | W 5-3 | 44-80 | 5 | 23,952 | Jorge de la Rosa | Esteban Loaiza | Ambiorix Burgos | Huston Street | Joe Nelson | 566 | 739 | -173 |
| 2006-08-19 | vs OAK | 125 | L 2-7 | 44-81 | 5 | 30,810 | Mark Redman | Barry Zito | Barry Zito | Mark Redman | | 568 | 746 | -178 |
| 2006-08-20 | vs OAK | 126 | L 4-6 | 44-82 | 5 | 16,592 | Runelvys Hernandez | Kirk Saarloos | Kirk Saarloos | Runelvys Hernandez | | 572 | 752 | -180 |
| 2006-08-22 | vs CLE | 127 | W 5-2 | 45-82 | 5 | 13,270 | Odalis Perez | Cliff Lee | Odalis Perez | Cliff Lee | Joe Nelson | 577 | 754 | -177 |
| 2006-08-23 | vs CLE | 128 | L 13-15 | 45-83 | 5 | 12,671 | Jorge de la Rosa | Paul Byrd | Rafael Betancourt | Andy Sisco | Tom Mastny | 590 | 769 | -179 |
| 2006-08-24 | vs CLE | 129 | L 4-8 | 45-84 | 5 | 13,098 | Mark Redman | CC Sabathia | CC Sabathia | Jimmy Gobble | | 594 | 777 | -183 |
| 2006-08-25 | @ TOR | 130 | L 3-6 | 45-85 | 5 | 26,343 | Luke Hudson | Shaun Marcum | Shaun Marcum | Luke Hudson | B.J. Ryan | 597 | 783 | -186 |
| 2006-08-26 | @ TOR | 131 | W 2-0 | 46-85 | 5 | 38,070 | Runelvys Hernandez | Roy Halladay | Runelvys Hernandez | Roy Halladay | | 599 | 783 | -184 |
| 2006-08-27 | @ TOR | 132 | L 6-10 | 46-86 | 5 | 36,417 | Odalis Perez | Ted Lilly | Ted Lilly | Odalis Perez | | 605 | 793 | -188 |
| 2006-08-29 | @ MIN | 133 | W 2-0 | 47-86 | 5 | 24,904 | Mark Redman | Matt Garza | Mark Redman | Matt Garza | | 607 | 793 | -186 |
| 2006-08-30 | @ MIN | 134 | W 4-3 | 48-86 | 5 | 28,668 | Luke Hudson | Boof Bonser | Luke Hudson | Boof Bonser | Joe Nelson | 611 | 796 | -185 |
| 2006-08-31 | @ MIN | 135 | L 1-3 | 48-87 | 5 | 21,287 | Jorge de la Rosa | Johan Santana | Johan Santana | Jorge de la Rosa | Joe Nathan | 612 | 799 | -187 |
| 2006-09-01 | vs CHA | 136 | W 7-5 | 49-87 | 5 | 15,501 | Runelvys Hernandez | Jose Contreras | Runelvys Hernandez | Jose Contreras | Joe Nelson | 619 | 804 | -185 |
| 2006-09-02 | vs CHA | 137 | L 3-5 | 49-88 | 5 | 18,028 | Odalis Perez | Mark Buehrle | Mark Buehrle | Odalis Perez | Bobby Jenks | 622 | 809 | -187 |
| 2006-09-03 | vs CHA | 138 | W 7-3 | 50-88 | 5 | 20,407 | Mark Redman | Freddy Garcia | Mark Redman | Freddy Garcia | | 629 | 812 | -183 |
| 2006-09-04 | vs NYA | 139 | L 5-12 | 50-89 | 5 | 27,123 | Luke Hudson | Chien-Ming Wang | T.J. Beam | Scott Dohmann | | 634 | 824 | -190 |
| 2006-09-05 | vs NYA | 140 | W 5-0 | 51-89 | 5 | 25,104 | Jorge de la Rosa | Mike Mussina | Jorge de la Rosa | Mike Mussina | Todd Wellemeyer | 639 | 824 | -185 |
| 2006-09-06 | vs NYA | 141 | L 3-8 | 51-90 | 5 | 16,421 | Runelvys Hernandez | Randy Johnson | Randy Johnson | Runelvys Hernandez | | 642 | 832 | -190 |
| 2006-09-08 | @ BOS | 142 | W 10-9 | 52-90 | 5 | 36,531 | Odalis Perez | Kevin Jarvis | Ambiorix Burgos | Mike Timlin | Joe Nelson | 652 | 841 | -189 |
| 2006-09-09 | @ BOS | 143 | W 10-4 | 53-90 | 5 | 36,402 | Luke Hudson | Josh Beckett | Joe Nelson | Craig Breslow | | 662 | 845 | -183 |
| 2006-09-10 | @ BOS | 144 | L 3-9 | 53-91 | 5 | 35,703 | Mark Redman | Julian Tavarez | Julian Tavarez | Mark Redman | | 665 | 854 | -189 |
| 2006-09-12 | @ CLE | 145 | W 5-3 | 54-91 | 5 | 18,883 | Runelvys Hernandez | Jeremy Sowers | Runelvys Hernandez | Jeremy Sowers | Joe Nelson | 670 | 857 | -187 |
| 2006-09-13 | @ CLE | 146 | W 6-2 | 55-91 | 5 | 20,089 | Jorge de la Rosa | Jake Westbrook | Jorge de la Rosa | Jake Westbrook | | 676 | 859 | -183 |
| 2006-09-14 | vs SEA | 147 | W 10-8 | 56-91 | 5 | 8,839 | Odalis Perez | Jarrod Washburn | Odalis Perez | Jarrod Washburn | | 686 | 867 | -181 |
| 2006-09-15 | vs SEA | 148 | L 8-11 | 56-92 | 5 | 16,412 | Luke Hudson | Francisco Cruceta | Jake Woods | Ryan Braun | | 694 | 878 | -184 |
| 2006-09-16 | vs SEA | 149 | W 7-4 | 57-92 | 5 | 12,116 | Mark Redman | Joel Pineiro | Mark Redman | Joel Pineiro | Joe Nelson | 701 | 882 | -181 |
| 2006-09-17 | vs SEA | 150 | L 5-10 | 57-93 | 5 | 9,817 | Runelvys Hernandez | Gil Meche | Gil Meche | Jimmy Gobble | | 706 | 892 | -186 |
| 2006-09-19 | vs ANA | 151 | L 2-5 | 57-94 | 5 | 9,048 | Jorge de la Rosa | Joe Saunders | Joe Saunders | Jorge de la Rosa | Francisco Rodriguez | 708 | 897 | -189 |
| 2006-09-20 | vs ANA | 152 | L 0-3 | 57-95 | 5 | 8,947 | Odalis Perez | Kelvim Escobar | Kelvim Escobar | Odalis Perez | Francisco Rodriguez | 708 | 900 | -192 |
| 2006-09-22 | vs DET | 153 | L 3-7 | 57-96 | 5 | 13,151 | Luke Hudson | Wil Ledezma | Wil Ledezma | Luke Hudson | | 711 | 907 | -196 |
| 2006-09-23 | vs DET | 154 | L 4-15 | 57-97 | 5 | 15,459 | Mark Redman | Kenny Rogers | Kenny Rogers | Mark Redman | | 715 | 922 | -207 |
| 2006-09-24 | vs DET | 155 | L 4-11 | 57-98 | 5 | 10,922 | Runelvys Hernandez | Justin Verlander | Justin Verlander | Runelvys Hernandez | | 719 | 933 | -214 |
| 2006-09-25 | @ MIN | 156 | L 1-8 | 57-99 | 5 | 18,108 | Jorge de la Rosa | Boof Bonser | Boof Bonser | Jorge de la Rosa | | 720 | 941 | -221 |
| 2006-09-26 | @ MIN | 157 | L 2-3 | 57-100 | 5 | 24,819 | Odalis Perez | Johan Santana | Johan Santana | Joel Peralta | Joe Nathan | 722 | 944 | -222 |
| 2006-09-27 | @ MIN | 158 | W 6-4 | 58-100 | 5 | 28,540 | Mark Redman | Carlos Silva | Mark Redman | Carlos Silva | Joe Nelson | 728 | 948 | -220 |
| 2006-09-28 | @ MIN | 159 | L 1-2 | 58-101 | 5 | 26,654 | Luke Hudson | Brad Radke | Joe Nathan | Scott Dohmann | | 729 | 950 | -221 |
| 2006-09-29 | @ DET | 160 | W 9-7 | 59-101 | 5 | 37,243 | Runelvys Hernandez | Wil Ledezma | Zack Greinke | Jamie Walker | Joel Peralta | 738 | 957 | -219 |
| 2006-09-30 | @ DET | 161 | W 9-6 | 60-101 | 5 | 40,071 | Ambiorix Burgos | Zach Miner | Todd Wellemeyer | Zach Miner | Jimmy Gobble | 747 | 963 | -216 |
| 2006-10-01 | @ DET | 162 | W 10-8 | 61-101 | 5 | 40,155 | Odalis Perez | Jeremy Bonderman | Jimmy Gobble | Kenny Rogers | | 757 | 971 | -214 |