| 2006-04-03 | @ KCA | 1 | W 3-1 | 1-0 | 2 | 41,054 | Kenny Rogers | Scott Elarton | Kenny Rogers | Scott Elarton | Fernando Rodney | 3 | 1 | 2 |
| 2006-04-05 | @ KCA | 2 | W 14-3 | 2-0 | 1 | 11,265 | Jeremy Bonderman | Joe Mays | Jeremy Bonderman | Joe Mays | | 17 | 4 | 13 |
| 2006-04-06 | @ TEX | 3 | W 10-6 | 3-0 | 1 | 21,713 | Nate Robertson | R.A. Dickey | Nate Robertson | R.A. Dickey | | 27 | 10 | 17 |
| 2006-04-07 | @ TEX | 4 | W 5-2 | 4-0 | 1 | 21,155 | Mike Maroth | John Koronka | Mike Maroth | John Koronka | Fernando Rodney | 32 | 12 | 20 |
| 2006-04-08 | @ TEX | 5 | W 7-0 | 5-0 | 1 | 35,066 | Justin Verlander | Kevin Millwood | Justin Verlander | Kevin Millwood | | 39 | 12 | 27 |
| 2006-04-09 | @ TEX | 6 | L 3-5 | 5-1 | 2 | 31,032 | Kenny Rogers | Vicente Padilla | Vicente Padilla | Kenny Rogers | Francisco Cordero | 42 | 17 | 25 |
| 2006-04-10 | vs CHA | 7 | L 3-5 | 5-2 | 2 | 44,179 | Jeremy Bonderman | Freddy Garcia | Freddy Garcia | Jeremy Bonderman | Bobby Jenks | 45 | 22 | 23 |
| 2006-04-12 | vs CHA | 8 | L 3-4 | 5-3 | 2 | 12,601 | Nate Robertson | Jose Contreras | Jose Contreras | Nate Robertson | Bobby Jenks | 48 | 26 | 22 |
| 2006-04-13 | vs CHA | 9 | L 9-13 | 5-4 | 3 | 14,027 | Justin Verlander | Jon Garland | Jon Garland | Justin Verlander | | 57 | 39 | 18 |
| 2006-04-14 | vs CLE | 10 | W 5-1 | 6-4 | 2 | 27,358 | Kenny Rogers | Jake Westbrook | Kenny Rogers | Jake Westbrook | | 62 | 40 | 22 |
| 2006-04-15 | vs CLE | 11 | L 2-7 | 6-5 | 3 | 30,107 | Jeremy Bonderman | Fausto Carmona | Fausto Carmona | Jeremy Bonderman | | 64 | 47 | 17 |
| 2006-04-16 | vs CLE | 12 | W 1-0 | 7-5 | 3 | 14,303 | Mike Maroth | Cliff Lee | Mike Maroth | Cliff Lee | Fernando Rodney | 65 | 47 | 18 |
| 2006-04-17 | vs CLE | 13 | L 2-10 | 7-6 | 3 | 19,126 | Nate Robertson | Paul Byrd | Paul Byrd | Nate Robertson | | 67 | 57 | 10 |
| 2006-04-18 | @ OAK | 14 | L 3-4 | 7-7 | 3 | 16,857 | Justin Verlander | Esteban Loaiza | Justin Duchscherer | Justin Verlander | Huston Street | 70 | 61 | 9 |
| 2006-04-19 | @ OAK | 15 | W 11-4 | 8-7 | 3 | 18,309 | Kenny Rogers | Joe Blanton | Kenny Rogers | Joe Blanton | | 81 | 65 | 16 |
| 2006-04-20 | @ OAK | 16 | W 4-3 | 9-7 | 3 | 15,489 | Jeremy Bonderman | Barry Zito | Fernando Rodney | Justin Duchscherer | | 85 | 68 | 17 |
| 2006-04-21 | @ SEA | 17 | W 2-1 | 10-7 | 3 | 35,237 | Mike Maroth | Jarrod Washburn | Mike Maroth | Jarrod Washburn | Todd Jones | 87 | 69 | 18 |
| 2006-04-22 | @ SEA | 18 | W 2-0 | 11-7 | 2 | 27,893 | Nate Robertson | Gil Meche | Nate Robertson | Gil Meche | Fernando Rodney | 89 | 69 | 20 |
| 2006-04-23 | @ SEA | 19 | W 6-4 | 12-7 | 2 | 28,659 | Justin Verlander | Felix Hernandez | Justin Verlander | Felix Hernandez | Todd Jones | 95 | 73 | 22 |
| 2006-04-24 | @ ANA | 20 | L 0-3 | 12-8 | 2 | 39,776 | Kenny Rogers | Ervin Santana | Ervin Santana | Kenny Rogers | Francisco Rodriguez | 95 | 76 | 19 |
| 2006-04-25 | @ ANA | 21 | W 5-2 | 13-8 | 2 | 40,007 | Jeremy Bonderman | Hector Carrasco | Jeremy Bonderman | Hector Carrasco | Todd Jones | 100 | 78 | 22 |
| 2006-04-26 | @ ANA | 22 | L 0-4 | 13-9 | 2 | 37,532 | Mike Maroth | John Lackey | John Lackey | Mike Maroth | | 100 | 82 | 18 |
| 2006-04-28 | vs MIN | 23 | W 9-0 | 14-9 | 2 | 23,263 | Nate Robertson | Brad Radke | Nate Robertson | Brad Radke | | 109 | 82 | 27 |
| 2006-04-29 | vs MIN | 24 | W 18-1 | 15-9 | 2 | 24,258 | Justin Verlander | Carlos Silva | Justin Verlander | Carlos Silva | | 127 | 83 | 44 |
| 2006-04-30 | vs MIN | 25 | W 6-0 | 16-9 | 2 | 24,323 | Kenny Rogers | Kyle Lohse | Kenny Rogers | Kyle Lohse | | 133 | 83 | 50 |
| 2006-05-01 | vs KCA | 26 | W 3-2 | 17-9 | 2 | 9,597 | Jeremy Bonderman | Runelvys Hernandez | Jeremy Bonderman | Runelvys Hernandez | Todd Jones | 136 | 85 | 51 |
| 2006-05-02 | vs KCA | 27 | W 4-1 | 18-9 | 2 | 12,415 | Mike Maroth | Mark Redman | Mike Maroth | Mark Redman | Todd Jones | 140 | 86 | 54 |
| 2006-05-03 | vs ANA | 28 | W 2-1 | 19-9 | 2 | 17,171 | Nate Robertson | Jeff Weaver | Joel Zumaya | Jeff Weaver | Fernando Rodney | 142 | 87 | 55 |
| 2006-05-04 | vs ANA | 29 | L 2-7 | 19-10 | 2 | 24,879 | Justin Verlander | Kevin Gregg | Kevin Gregg | Justin Verlander | | 144 | 94 | 50 |
| 2006-05-05 | @ MIN | 30 | W 9-6 | 20-10 | 2 | 23,892 | Kenny Rogers | Kyle Lohse | Kenny Rogers | Kyle Lohse | Todd Jones | 153 | 100 | 53 |
| 2006-05-06 | @ MIN | 31 | L 6-7 | 20-11 | 2 | 20,907 | Jeremy Bonderman | Scott Baker | Juan Rincon | Todd Jones | | 159 | 107 | 52 |
| 2006-05-07 | @ MIN | 32 | L 2-4 | 20-12 | 2 | 20,548 | Mike Maroth | Johan Santana | Johan Santana | Mike Maroth | Joe Nathan | 161 | 111 | 50 |
| 2006-05-09 | @ BAL | 33 | L 6-7 | 20-13 | 2 | 16,566 | Nate Robertson | Daniel Cabrera | LaTroy Hawkins | Fernando Rodney | Chris Ray | 167 | 118 | 49 |
| 2006-05-10 | @ BAL | 34 | W 6-3 | 21-13 | 2 | 15,548 | Justin Verlander | Rodrigo Lopez | Justin Verlander | Rodrigo Lopez | Todd Jones | 173 | 121 | 52 |
| 2006-05-12 | @ CLE | 35 | W 5-4 | 22-13 | 2 | 23,588 | Kenny Rogers | Cliff Lee | Kenny Rogers | Cliff Lee | Todd Jones | 178 | 125 | 53 |
| 2006-05-13 | @ CLE | 36 | W 3-0 | 23-13 | 2 | 24,051 | Jeremy Bonderman | CC Sabathia | Jeremy Bonderman | CC Sabathia | Todd Jones | 181 | 125 | 56 |
| 2006-05-14 | @ CLE | 37 | W 3-2 | 24-13 | 2 | 21,875 | Mike Maroth | Jason Johnson | Mike Maroth | Jason Johnson | Fernando Rodney | 184 | 127 | 57 |
| 2006-05-16 | vs MIN | 38 | W 7-4 | 25-13 | 2 | 18,115 | Nate Robertson | Kyle Lohse | Nate Robertson | Kyle Lohse | Todd Jones | 191 | 131 | 60 |
| 2006-05-17 | vs MIN | 39 | W 2-0 | 26-13 | 2 | 16,669 | Justin Verlander | Johan Santana | Justin Verlander | Johan Santana | Todd Jones | 193 | 131 | 62 |
| 2006-05-18 | vs MIN | 40 | W 5-3 | 27-13 | 2 | 26,732 | Kenny Rogers | Brad Radke | Kenny Rogers | Brad Radke | Todd Jones | 198 | 134 | 64 |
| 2006-05-19 | vs CIN | 41 | L 4-9 | 27-14 | 2 | 26,933 | Jeremy Bonderman | Brandon Claussen | Brandon Claussen | Jeremy Bonderman | | 202 | 143 | 59 |
| 2006-05-20 | vs CIN | 42 | W 7-6 | 28-14 | 2 | 43,128 | Mike Maroth | Eric Milton | Fernando Rodney | David Weathers | | 209 | 149 | 60 |
| 2006-05-21 | vs CIN | 43 | W 1-0 | 29-14 | 2 | 31,515 | Nate Robertson | Aaron Harang | Fernando Rodney | Aaron Harang | Todd Jones | 210 | 149 | 61 |
| 2006-05-22 | @ KCA | 44 | W 8-0 | 30-14 | 2 | 9,746 | Justin Verlander | Jeremy Affeldt | Justin Verlander | Jeremy Affeldt | | 218 | 149 | 69 |
| 2006-05-23 | @ KCA | 45 | W 8-5 | 31-14 | 2 | 15,556 | Kenny Rogers | Runelvys Hernandez | Joel Zumaya | Elmer Dessens | Todd Jones | 226 | 154 | 72 |
| 2006-05-24 | @ KCA | 46 | W 6-3 | 32-14 | 2 | 10,745 | Jeremy Bonderman | Jimmy Gobble | Jeremy Bonderman | Jimmy Gobble | Todd Jones | 232 | 157 | 75 |
| 2006-05-25 | @ KCA | 47 | W 13-8 | 33-14 | 1 | 11,488 | Mike Maroth | Denny Bautista | Joel Zumaya | Elmer Dessens | | 245 | 165 | 80 |
| 2006-05-26 | vs CLE | 48 | W 8-3 | 34-14 | 1 | 31,241 | Nate Robertson | Jake Westbrook | Nate Robertson | Jake Westbrook | | 253 | 168 | 85 |
| 2006-05-27 | vs CLE | 49 | W 3-1 | 35-14 | 1 | 37,102 | Justin Verlander | Paul Byrd | Justin Verlander | Paul Byrd | Todd Jones | 256 | 169 | 87 |
| 2006-05-28 | vs CLE | 50 | L 0-9 | 35-15 | 1 | 37,908 | Kenny Rogers | Jason Johnson | Jason Johnson | Kenny Rogers | | 256 | 178 | 78 |
| 2006-05-29 | vs NYA | 51 | L 0-4 | 35-16 | 1 | 39,759 | Jeremy Bonderman | Randy Johnson | Randy Johnson | Jeremy Bonderman | | 256 | 182 | 74 |
| 2006-05-30 | vs NYA | 52 | L 6-11 | 35-17 | 1 | 24,765 | Roman Colon | Aaron Small | Mariano Rivera | Todd Jones | | 262 | 193 | 69 |
| 2006-05-31 | vs NYA | 53 | L 1-6 | 35-18 | 1 | 23,757 | Nate Robertson | Mike Mussina | Mike Mussina | Nate Robertson | | 263 | 199 | 64 |
| 2006-06-01 | vs NYA | 54 | W 7-6 | 36-18 | 1 | 27,231 | Justin Verlander | Chien-Ming Wang | Fernando Rodney | Kyle Farnsworth | | 270 | 205 | 65 |
| 2006-06-02 | vs BOS | 55 | L 2-3 | 36-19 | 1 | 35,531 | Kenny Rogers | Curt Schilling | Rudy Seanez | Todd Jones | Jonathan Papelbon | 272 | 208 | 64 |
| 2006-06-03 | vs BOS | 56 | W 6-2 | 37-19 | 1 | 40,872 | Jeremy Bonderman | Tim Wakefield | Jeremy Bonderman | Tim Wakefield | Fernando Rodney | 278 | 210 | 68 |
| 2006-06-04 | vs BOS | 57 | L 3-8 | 37-20 | 1 | 35,764 | Zach Miner | Matt Clement | Matt Clement | Zach Miner | | 281 | 218 | 63 |
| 2006-06-06 | @ CHA | 58 | L 3-4 | 37-21 | 1 | 37,192 | Nate Robertson | Freddy Garcia | Brandon McCarthy | Fernando Rodney | Bobby Jenks | 284 | 222 | 62 |
| 2006-06-07 | @ CHA | 59 | L 3-4 | 37-22 | 2 | 37,612 | Justin Verlander | Jose Contreras | Jose Contreras | Justin Verlander | Bobby Jenks | 287 | 226 | 61 |
| 2006-06-08 | @ CHA | 60 | W 6-2 | 38-22 | 1 | 37,354 | Kenny Rogers | Jon Garland | Kenny Rogers | Jon Garland | | 293 | 228 | 65 |
| 2006-06-09 | @ TOR | 61 | L 5-10 | 38-23 | 2 | 21,425 | Jeremy Bonderman | Gustavo Chacin | Jason Frasor | Todd Jones | | 298 | 238 | 60 |
| 2006-06-10 | @ TOR | 62 | W 5-3 | 39-23 | 2 | 27,021 | Zach Miner | Ted Lilly | Zach Miner | Ted Lilly | Todd Jones | 303 | 241 | 62 |
| 2006-06-11 | @ TOR | 63 | W 10-5 | 40-23 | 1 | 30,404 | Nate Robertson | Ty Taubenheim | Nate Robertson | Ty Taubenheim | Joel Zumaya | 313 | 246 | 67 |
| 2006-06-12 | vs TBA | 64 | W 4-3 | 41-23 | 1 | 16,302 | Justin Verlander | Scott Kazmir | Todd Jones | Brian Meadows | | 317 | 249 | 68 |
| 2006-06-13 | vs TBA | 65 | W 7-1 | 42-23 | 1 | 20,935 | Kenny Rogers | Seth McClung | Kenny Rogers | Seth McClung | | 324 | 250 | 74 |
| 2006-06-14 | vs TBA | 66 | L 1-5 | 42-24 | 1 | 25,265 | Jeremy Bonderman | Mark Hendrickson | Brian Meadows | Todd Jones | | 325 | 255 | 70 |
| 2006-06-15 | vs TBA | 67 | W 6-2 | 43-24 | 1 | 28,269 | Zach Miner | Casey Fossum | Zach Miner | Casey Fossum | | 331 | 257 | 74 |
| 2006-06-16 | @ CHN | 68 | W 5-3 | 44-24 | 1 | 40,683 | Nate Robertson | Glendon Rusch | Nate Robertson | Glendon Rusch | Todd Jones | 336 | 260 | 76 |
| 2006-06-17 | @ CHN | 69 | W 9-3 | 45-24 | 1 | 41,459 | Justin Verlander | Carlos Marmol | Justin Verlander | Carlos Marmol | | 345 | 263 | 82 |
| 2006-06-18 | @ CHN | 70 | W 12-3 | 46-24 | 1 | 39,938 | Kenny Rogers | Mark Prior | Kenny Rogers | Mark Prior | | 357 | 266 | 91 |
| 2006-06-19 | @ MIL | 71 | W 3-1 | 47-24 | 1 | 29,623 | Jeremy Bonderman | Doug Davis | Jeremy Bonderman | Matt Wise | Todd Jones | 360 | 267 | 93 |
| 2006-06-20 | @ MIL | 72 | W 10-1 | 48-24 | 1 | 33,119 | Zach Miner | Rick Helling | Zach Miner | Rick Helling | | 370 | 268 | 102 |
| 2006-06-21 | @ MIL | 73 | L 3-4 | 48-25 | 2 | 31,222 | Nate Robertson | Chris Capuano | Chris Capuano | Joel Zumaya | Derrick Turnbow | 373 | 272 | 101 |
| 2006-06-23 | vs SLN | 74 | W 10-6 | 49-25 | 2 | 42,238 | Justin Verlander | Chris Carpenter | Justin Verlander | Chris Carpenter | | 383 | 278 | 105 |
| 2006-06-24 | vs SLN | 75 | W 7-6 | 50-25 | 2 | 42,535 | Kenny Rogers | Jeff Suppan | Joel Zumaya | Tyler Johnson | | 390 | 284 | 106 |
| 2006-06-25 | vs SLN | 76 | W 4-1 | 51-25 | 1 | 40,644 | Jeremy Bonderman | Sidney Ponson | Wil Ledezma | Sidney Ponson | Todd Jones | 394 | 285 | 109 |
| 2006-06-26 | vs HOU | 77 | W 10-4 | 52-25 | 1 | 24,285 | Zach Miner | Wandy Rodriguez | Zach Miner | Wandy Rodriguez | | 404 | 289 | 115 |
| 2006-06-27 | vs HOU | 78 | W 4-0 | 53-25 | 1 | 39,852 | Nate Robertson | Roger Clemens | Nate Robertson | Roger Clemens | | 408 | 289 | 119 |
| 2006-06-28 | vs HOU | 79 | W 5-0 | 54-25 | 1 | 29,249 | Justin Verlander | Andy Pettitte | Justin Verlander | Andy Pettitte | | 413 | 289 | 124 |
| 2006-06-30 | @ PIT | 80 | W 7-6 | 55-25 | 1 | 27,318 | Kenny Rogers | Kip Wells | Roman Colon | Kip Wells | Todd Jones | 420 | 295 | 125 |
| 2006-07-01 | @ PIT | 81 | L 2-9 | 55-26 | 1 | 37,111 | Jeremy Bonderman | Tom Gorzelanny | Matt Capps | Jason Grilli | | 422 | 304 | 118 |
| 2006-07-02 | @ PIT | 82 | W 9-8 | 56-26 | 1 | 28,136 | Zach Miner | Ian Snell | Zach Miner | Ian Snell | Todd Jones | 431 | 312 | 119 |
| 2006-07-03 | @ OAK | 83 | L 3-5 | 56-27 | 1 | 35,077 | Nate Robertson | Joe Blanton | Joe Blanton | Nate Robertson | Huston Street | 434 | 317 | 117 |
| 2006-07-04 | @ OAK | 84 | L 1-2 | 56-28 | 1 | 21,096 | Justin Verlander | Dan Haren | Chad Gaudin | Fernando Rodney | | 435 | 319 | 116 |
| 2006-07-05 | @ OAK | 85 | W 10-4 | 57-28 | 1 | 22,210 | Kenny Rogers | Kirk Saarloos | Kenny Rogers | Kirk Saarloos | Roman Colon | 445 | 323 | 122 |
| 2006-07-07 | @ SEA | 86 | W 6-1 | 58-28 | 1 | 31,727 | Jeremy Bonderman | Joel Pineiro | Jeremy Bonderman | Joel Pineiro | | 451 | 324 | 127 |
| 2006-07-08 | @ SEA | 87 | W 2-1 | 59-28 | 1 | 32,404 | Zach Miner | Jarrod Washburn | Zach Miner | Jarrod Washburn | Todd Jones | 453 | 325 | 128 |
| 2006-07-09 | @ SEA | 88 | L 2-3 | 59-29 | 1 | 37,364 | Nate Robertson | Gil Meche | Gil Meche | Nate Robertson | J.J. Putz | 455 | 328 | 127 |
| 2006-07-13 | vs KCA | 89 | W 6-4 | 60-29 | 1 | 31,967 | Jeremy Bonderman | Brandon Duckworth | Jeremy Bonderman | Brandon Duckworth | Todd Jones | 461 | 332 | 129 |
| 2006-07-14 | vs KCA | 90 | W 10-9 | 61-29 | 1 | 38,442 | Kenny Rogers | Mark Redman | Todd Jones | Jeremy Affeldt | | 471 | 341 | 130 |
| 2006-07-15 | vs KCA | 91 | W 6-0 | 62-29 | 1 | 40,210 | Justin Verlander | Jimmy Gobble | Justin Verlander | Jimmy Gobble | | 477 | 341 | 136 |
| 2006-07-16 | vs KCA | 92 | L 6-9 | 62-30 | 1 | 37,893 | Zach Miner | Scott Elarton | Scott Elarton | Zach Miner | Mike MacDougal | 483 | 350 | 133 |
| 2006-07-18 | vs CHA | 93 | L 1-7 | 62-31 | 1 | 39,153 | Nate Robertson | Jon Garland | Jon Garland | Nate Robertson | | 484 | 357 | 127 |
| 2006-07-19 | vs CHA | 94 | W 5-2 | 63-31 | 1 | 39,593 | Jeremy Bonderman | Javier Vazquez | Jeremy Bonderman | Javier Vazquez | | 489 | 359 | 130 |
| 2006-07-20 | vs CHA | 95 | W 2-1 | 64-31 | 1 | 41,075 | Kenny Rogers | Jose Contreras | Joel Zumaya | Jose Contreras | Todd Jones | 491 | 360 | 131 |
| 2006-07-21 | vs OAK | 96 | W 7-4 | 65-31 | 1 | 40,687 | Justin Verlander | Dan Haren | Justin Verlander | Dan Haren | | 498 | 364 | 134 |
| 2006-07-22 | vs OAK | 97 | L 5-9 | 65-32 | 1 | 38,923 | Zach Miner | Joe Blanton | Joe Blanton | Wil Ledezma | | 503 | 373 | 130 |
| 2006-07-23 | vs OAK | 98 | W 8-4 | 66-32 | 1 | 40,355 | Nate Robertson | Esteban Loaiza | Nate Robertson | Esteban Loaiza | | 511 | 377 | 134 |
| 2006-07-24 | @ CLE | 99 | W 9-7 | 67-32 | 1 | 19,045 | Jeremy Bonderman | Cliff Lee | Jeremy Bonderman | Cliff Lee | Todd Jones | 520 | 384 | 136 |
| 2006-07-25 | @ CLE | 100 | L 7-12 | 67-33 | 1 | 28,085 | Kenny Rogers | Paul Byrd | Jason Davis | Kenny Rogers | | 527 | 396 | 131 |
| 2006-07-26 | @ CLE | 101 | W 4-1 | 68-33 | 1 | 31,220 | Justin Verlander | CC Sabathia | Justin Verlander | CC Sabathia | Todd Jones | 531 | 397 | 134 |
| 2006-07-28 | @ MIN | 102 | W 3-2 | 69-33 | 1 | 45,478 | Zach Miner | Francisco Liriano | Fernando Rodney | Juan Rincon | Todd Jones | 534 | 399 | 135 |
| 2006-07-29 | @ MIN | 103 | W 8-6 | 70-33 | 1 | 45,496 | Nate Robertson | Brad Radke | Nate Robertson | Brad Radke | Todd Jones | 542 | 405 | 137 |
| 2006-07-30 | @ MIN | 104 | L 4-6 | 70-34 | 1 | 43,204 | Jeremy Bonderman | Johan Santana | Pat Neshek | Jeremy Bonderman | Joe Nathan | 546 | 411 | 135 |
| 2006-07-31 | @ TBA | 105 | L 3-7 | 70-35 | 1 | 15,065 | Kenny Rogers | Casey Fossum | Casey Fossum | Kenny Rogers | | 549 | 418 | 131 |
| 2006-08-01 | @ TBA | 106 | W 10-4 | 71-35 | 1 | 13,808 | Justin Verlander | J.P. Howell | Justin Verlander | J.P. Howell | | 559 | 422 | 137 |
| 2006-08-02 | @ TBA | 107 | W 8-3 | 72-35 | 1 | 13,126 | Zach Miner | Tim Corcoran | Jason Grilli | Jon Switzer | | 567 | 425 | 142 |
| 2006-08-03 | @ TBA | 108 | L 1-2 | 72-36 | 1 | 12,665 | Nate Robertson | Jae Weong Seo | Seth McClung | Nate Robertson | Brian Meadows | 568 | 427 | 141 |
| 2006-08-04 | vs CLE | 109 | W 7-6 | 73-36 | 1 | 41,502 | Jeremy Bonderman | Cliff Lee | Roman Colon | Fernando Cabrera | Todd Jones | 575 | 433 | 142 |
| 2006-08-05 | vs CLE | 110 | W 4-3 | 74-36 | 1 | 43,015 | Kenny Rogers | Paul Byrd | Joel Zumaya | Fausto Carmona | | 579 | 436 | 143 |
| 2006-08-06 | vs CLE | 111 | W 1-0 | 75-36 | 1 | 39,178 | Wil Ledezma | CC Sabathia | Wil Ledezma | CC Sabathia | Todd Jones | 580 | 436 | 144 |
| 2006-08-07 | vs MIN | 112 | W 9-3 | 76-36 | 1 | 34,870 | Zach Miner | Francisco Liriano | Zach Miner | Francisco Liriano | | 589 | 439 | 150 |
| 2006-08-08 | vs MIN | 113 | L 2-4 | 76-37 | 1 | 35,624 | Nate Robertson | Brad Radke | Brad Radke | Nate Robertson | Joe Nathan | 591 | 443 | 148 |
| 2006-08-09 | vs MIN | 114 | L 3-4 | 76-38 | 1 | 36,339 | Jeremy Bonderman | Johan Santana | Johan Santana | Joel Zumaya | Joe Nathan | 594 | 447 | 147 |
| 2006-08-11 | @ CHA | 115 | L 0-5 | 76-39 | 1 | 39,378 | Justin Verlander | Jose Contreras | Jose Contreras | Justin Verlander | | 594 | 452 | 142 |
| 2006-08-12 | @ CHA | 116 | L 3-4 | 76-40 | 1 | 38,873 | Kenny Rogers | Mark Buehrle | Mike MacDougal | Kenny Rogers | Bobby Jenks | 597 | 456 | 141 |
| 2006-08-13 | @ CHA | 117 | L 3-7 | 76-41 | 1 | 38,931 | Zach Miner | Freddy Garcia | Freddy Garcia | Zach Miner | Bobby Jenks | 600 | 463 | 137 |
| 2006-08-14 | @ BOS | 118 | W 7-4 | 77-41 | 1 | 36,392 | Nate Robertson | Josh Beckett | Nate Robertson | Josh Beckett | Todd Jones | 607 | 467 | 140 |
| 2006-08-15 | @ BOS | 119 | W 3-2 | 78-41 | 1 | 36,179 | Jeremy Bonderman | Curt Schilling | Fernando Rodney | Mike Timlin | Todd Jones | 610 | 469 | 141 |
| 2006-08-16 | @ BOS | 120 | L 4-6 | 78-42 | 1 | 36,304 | Justin Verlander | David Wells | David Wells | Justin Verlander | Jonathan Papelbon | 614 | 475 | 139 |
| 2006-08-17 | vs TEX | 121 | W 4-2 | 79-42 | 1 | 34,756 | Kenny Rogers | Edinson Volquez | Kenny Rogers | Edinson Volquez | Todd Jones | 618 | 477 | 141 |
| 2006-08-18 | vs TEX | 122 | L 1-2 | 79-43 | 1 | 39,327 | Zach Miner | Kevin Millwood | Kevin Millwood | Zach Miner | Akinori Otsuka | 619 | 479 | 140 |
| 2006-08-19 | vs TEX | 123 | L 1-3 | 79-44 | 1 | 41,643 | Nate Robertson | Rob Tejeda | Rob Tejeda | Nate Robertson | Akinori Otsuka | 620 | 482 | 138 |
| 2006-08-20 | vs TEX | 124 | L 6-7 | 79-45 | 1 | 39,071 | Jeremy Bonderman | John Koronka | Joaquin Benoit | Jason Grilli | Akinori Otsuka | 626 | 489 | 137 |
| 2006-08-21 | vs CHA | 125 | W 7-1 | 80-45 | 1 | 39,278 | Justin Verlander | Jose Contreras | Justin Verlander | Jose Contreras | | 633 | 490 | 143 |
| 2006-08-22 | vs CHA | 126 | W 4-0 | 81-45 | 1 | 39,361 | Kenny Rogers | Mark Buehrle | Kenny Rogers | Mark Buehrle | | 637 | 490 | 147 |
| 2006-08-23 | vs CHA | 127 | L 5-7 | 81-46 | 1 | 40,187 | Zach Miner | Freddy Garcia | Freddy Garcia | Zach Miner | Bobby Jenks | 642 | 497 | 145 |
| 2006-08-24 | vs CHA | 128 | L 0-10 | 81-47 | 1 | 41,565 | Nate Robertson | Jon Garland | Jon Garland | Nate Robertson | | 642 | 507 | 135 |
| 2006-08-25 | @ CLE | 129 | L 2-4 | 81-48 | 1 | 33,416 | Jeremy Bonderman | Jeremy Sowers | Jeremy Sowers | Jeremy Bonderman | Rafael Betancourt | 644 | 511 | 133 |
| 2006-08-26 | @ CLE | 130 | L 5-8 | 81-49 | 1 | 29,138 | Justin Verlander | Jake Westbrook | Jake Westbrook | Justin Verlander | Tom Mastny | 649 | 519 | 130 |
| 2006-08-27 | @ CLE | 131 | W 7-1 | 82-49 | 1 | 28,342 | Kenny Rogers | Cliff Lee | Kenny Rogers | Cliff Lee | | 656 | 520 | 136 |
| 2006-08-30 | @ NYA | 132 | L 0-2 | 83-50 | 1 | 52,585 | Nate Robertson | Chien-Ming Wang | Chien-Ming Wang | Nate Robertson | Mariano Rivera | 656 | 522 | 134 |
| 2006-08-30 | @ NYA | 133 | W 5-3 | 83-50 | 1 | 54,509 | Wil Ledezma | Jaret Wright | Jason Grilli | Scott Proctor | Todd Jones | 661 | 525 | 136 |
| 2006-08-31 | @ NYA | 134 | L 4-6 | 83-51 | 1 | 54,771 | Jeremy Bonderman | Randy Johnson | Randy Johnson | Jeremy Bonderman | Mariano Rivera | 665 | 531 | 134 |
| 2006-09-01 | vs ANA | 135 | W 9-0 | 84-51 | 1 | 37,509 | Kenny Rogers | Ervin Santana | Kenny Rogers | Ervin Santana | | 674 | 531 | 143 |
| 2006-09-02 | vs ANA | 136 | L 2-7 | 84-52 | 1 | 37,826 | Justin Verlander | Joe Saunders | Francisco Rodriguez | Todd Jones | | 676 | 538 | 138 |
| 2006-09-03 | vs ANA | 137 | L 1-2 | 84-53 | 1 | 38,688 | Wil Ledezma | Kelvim Escobar | Kelvim Escobar | Wil Ledezma | Francisco Rodriguez | 677 | 540 | 137 |
| 2006-09-04 | vs SEA | 138 | W 6-2 | 85-53 | 1 | 32,948 | Nate Robertson | Jarrod Washburn | Nate Robertson | Jarrod Washburn | | 683 | 542 | 141 |
| 2006-09-05 | vs SEA | 139 | L 3-4 | 85-54 | 1 | 23,583 | Jeremy Bonderman | Jake Woods | Joel Pineiro | Andrew Miller | J.J. Putz | 686 | 546 | 140 |
| 2006-09-06 | vs SEA | 140 | L 4-5 | 85-55 | 1 | 23,066 | Kenny Rogers | Gil Meche | Jon Huber | Joel Zumaya | J.J. Putz | 690 | 551 | 139 |
| 2006-09-07 | @ MIN | 141 | W 7-2 | 86-55 | 1 | 21,229 | Justin Verlander | Scott Baker | Justin Verlander | Scott Baker | | 697 | 553 | 144 |
| 2006-09-08 | @ MIN | 142 | L 5-9 | 86-56 | 1 | 29,042 | Wil Ledezma | Matt Garza | Pat Neshek | Wil Ledezma | | 702 | 562 | 140 |
| 2006-09-09 | @ MIN | 143 | L 1-2 | 86-57 | 1 | 39,160 | Nate Robertson | Boof Bonser | Boof Bonser | Nate Robertson | Joe Nathan | 703 | 564 | 139 |
| 2006-09-10 | @ MIN | 144 | L 1-12 | 86-58 | 1 | 40,158 | Jeremy Bonderman | Johan Santana | Johan Santana | Jeremy Bonderman | | 704 | 576 | 128 |
| 2006-09-12 | vs TEX | 145 | W 3-2 | 87-58 | 1 | 24,196 | Kenny Rogers | Vicente Padilla | Fernando Rodney | Ron Mahay | | 707 | 578 | 129 |
| 2006-09-13 | vs TEX | 146 | L 3-11 | 87-59 | 1 | 24,672 | Justin Verlander | Kevin Millwood | Kevin Millwood | Justin Verlander | | 710 | 589 | 121 |
| 2006-09-15 | vs BAL | 147 | W 17-2 | 88-59 | 1 | 38,261 | Jeremy Bonderman | Hayden Penn | Jeremy Bonderman | Hayden Penn | | 727 | 591 | 136 |
| 2006-09-16 | vs BAL | 148 | W 2-0 | 89-59 | 1 | 39,030 | Nate Robertson | Kris Benson | Nate Robertson | Kris Benson | Todd Jones | 729 | 591 | 138 |
| 2006-09-17 | vs BAL | 149 | L 8-12 | 89-60 | 1 | 37,464 | Wil Ledezma | Daniel Cabrera | Chris Ray | Jason Grilli | | 737 | 603 | 134 |
| 2006-09-18 | @ CHA | 150 | W 8-2 | 90-60 | 1 | 39,427 | Kenny Rogers | Mark Buehrle | Kenny Rogers | Mark Buehrle | | 745 | 605 | 140 |
| 2006-09-19 | @ CHA | 151 | L 0-7 | 90-61 | 1 | 38,850 | Justin Verlander | Freddy Garcia | Freddy Garcia | Justin Verlander | | 745 | 612 | 133 |
| 2006-09-20 | @ CHA | 152 | W 6-2 | 91-61 | 1 | 38,971 | Jeremy Bonderman | Jon Garland | Jeremy Bonderman | Jon Garland | | 751 | 614 | 137 |
| 2006-09-21 | @ BAL | 153 | L 3-4 | 91-62 | 1 | 17,877 | Nate Robertson | Kris Benson | Kris Benson | Fernando Rodney | Chris Ray | 754 | 618 | 136 |
| 2006-09-22 | @ KCA | 154 | W 7-3 | 92-62 | 1 | 13,151 | Wil Ledezma | Luke Hudson | Wil Ledezma | Luke Hudson | | 761 | 621 | 140 |
| 2006-09-23 | @ KCA | 155 | W 15-4 | 93-62 | 1 | 15,459 | Kenny Rogers | Mark Redman | Kenny Rogers | Mark Redman | | 776 | 625 | 151 |
| 2006-09-24 | @ KCA | 156 | W 11-4 | 94-62 | 1 | 10,922 | Justin Verlander | Runelvys Hernandez | Justin Verlander | Runelvys Hernandez | | 787 | 629 | 158 |
| 2006-09-26 | vs TOR | 157 | W 4-3 | 95-62 | 1 | 27,908 | Jeremy Bonderman | Dustin McGowan | Jeremy Bonderman | Dustin McGowan | Todd Jones | 791 | 632 | 159 |
| 2006-09-27 | vs TOR | 158 | L 4-7 | 95-63 | 1 | 26,430 | Nate Robertson | Ted Lilly | Ted Lilly | Nate Robertson | B.J. Ryan | 795 | 639 | 156 |
| 2006-09-28 | vs TOR | 159 | L 6-8 | 95-64 | 1 | 28,670 | Kenny Rogers | A.J. Burnett | A.J. Burnett | Kenny Rogers | B.J. Ryan | 801 | 647 | 154 |
| 2006-09-29 | vs KCA | 160 | L 7-9 | 95-65 | 1 | 37,243 | Wil Ledezma | Runelvys Hernandez | Zack Greinke | Jamie Walker | Joel Peralta | 808 | 656 | 152 |
| 2006-09-30 | vs KCA | 161 | L 6-9 | 95-66 | 1 | 40,071 | Zach Miner | Ambiorix Burgos | Todd Wellemeyer | Zach Miner | Jimmy Gobble | 814 | 665 | 149 |
| 2006-10-01 | vs KCA | 162 | L 8-10 | 95-67 | 2 | 40,155 | Jeremy Bonderman | Odalis Perez | Jimmy Gobble | Kenny Rogers | | 822 | 675 | 147 |