| Jeremy Bonderman | 34 | 34 | 19 | 214 | 0 | 0 | -- | 0 | 0 | 0 | 0 | 0 | 0 | -- | 827 | 903 | 47 | 10 | 3 | 7 | 14 | 1 | 0 | 87 | 318 | 316 | 1.01 | 20 | 3303 | 2111 | 1192 | 549 | 544 | 384 | 32 | 169 | 18 |
| Roman Colon | 20 | 1 | 0 | 2.3 | 19 | 36.3 | 5.4 | 2 | 0 | 16 | 3 | 33 | 6 | 18.2 | 152 | 170 | 9 | 2 | 1 | 2 | 0 | 2 | 0 | 12 | 55 | 75 | 0.73 | 3 | 591 | 367 | 224 | 95 | 80 | 62 | 6 | 19 | 3 |
| Chad Durbin | 3 | 0 | 0 | 0 | 3 | 6 | 5.0 | 0 | 0 | 2 | 1 | 3 | 2 | 66.7 | 24 | 24 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 13 | 0.62 | 0 | 81 | 55 | 26 | 18 | 13 | 3 | 1 | 2 | 0 |
| Jason Grilli | 51 | 0 | 0 | 0 | 51 | 62 | 6.6 | 8 | 0 | 43 | 7 | 87 | 15 | 17.2 | 234 | 270 | 12 | 3 | 5 | 3 | 2 | 1 | 0 | 21 | 101 | 106 | 0.95 | 5 | 970 | 603 | 367 | 163 | 171 | 60 | 11 | 20 | 3 |
| Todd Jones | 62 | 0 | 0 | 0 | 62 | 64 | 9.0 | 1 | 6 | 7 | 3 | 15 | 8 | 53.3 | 254 | 272 | 7 | 4 | 3 | 3 | 0 | 0 | 0 | 4 | 128 | 102 | 1.25 | 8 | 932 | 644 | 288 | 148 | 212 | 54 | 6 | 22 | 1 |
| Wil Ledezma | 24 | 7 | 1 | 35.7 | 17 | 24.7 | 5.5 | 2 | 2 | 18 | 5 | 39 | 12 | 30.8 | 236 | 264 | 11 | 2 | 2 | 0 | 2 | 0 | 0 | 38 | 73 | 127 | 0.57 | 2 | 947 | 598 | 349 | 162 | 165 | 71 | 8 | 31 | 5 |
| Colby Lewis | 2 | 0 | 0 | 0 | 2 | 3 | 5.5 | 0 | 0 | 4 | 3 | 9 | 6 | 66.7 | 17 | 18 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 7 | 5 | 1.40 | 0 | 72 | 46 | 26 | 18 | 11 | 5 | 1 | 4 | 0 |
| Mike Maroth | 13 | 9 | 5 | 48 | 4 | 5.7 | 6.8 | 0 | 0 | 1 | 1 | 3 | 3 | 100.0 | 217 | 234 | 12 | 2 | 1 | 1 | 1 | 1 | 0 | 36 | 81 | 112 | 0.72 | 6 | 862 | 506 | 356 | 111 | 157 | 45 | 6 | 18 | 1 |
| Andrew Miller | 8 | 0 | 0 | 0 | 8 | 10.3 | 6.0 | 1 | 0 | 1 | 1 | 3 | 3 | 100.0 | 39 | 51 | 2 | 1 | 2 | 0 | 0 | 0 | 0 | 2 | 23 | 10 | 2.30 | 1 | 192 | 106 | 86 | 29 | 31 | 13 | 2 | 4 | 2 |
| Zach Miner | 27 | 16 | 6 | 79.7 | 11 | 13.3 | 6.2 | 1 | 0 | 7 | 3 | 15 | 6 | 40.0 | 362 | 398 | 18 | 2 | 0 | 1 | 8 | 4 | 1 | 38 | 151 | 156 | 0.97 | 7 | 1645 | 988 | 657 | 286 | 259 | 136 | 9 | 50 | 4 |
| Nate Robertson | 32 | 32 | 20 | 208.7 | 0 | 0 | -- | 0 | 0 | 0 | 0 | 0 | 0 | -- | 795 | 881 | 38 | 3 | 8 | 2 | 9 | 4 | 5 | 111 | 321 | 349 | 0.92 | 30 | 3114 | 1937 | 1177 | 441 | 566 | 261 | 43 | 93 | 12 |
| Fernando Rodney | 63 | 0 | 0 | 0 | 63 | 71.7 | 7.9 | 18 | 5 | 23 | 7 | 54 | 15 | 27.8 | 260 | 304 | 9 | 0 | 8 | 4 | 5 | 4 | 2 | 15 | 115 | 82 | 1.40 | 4 | 1207 | 733 | 474 | 188 | 207 | 141 | 19 | 46 | 6 |
| Kenny Rogers | 34 | 33 | 19 | 202 | 1 | 2 | 11.0 | 0 | 0 | 0 | 0 | 0 | 0 | -- | 770 | 849 | 41 | 2 | 9 | 2 | 1 | 4 | 5 | 115 | 340 | 339 | 1.00 | 25 | 3113 | 1914 | 1199 | 433 | 599 | 203 | 41 | 58 | 7 |
| Bobby Seay | 14 | 0 | 0 | 0 | 14 | 15.3 | 7.0 | 0 | 0 | 5 | 1 | 12 | 3 | 25.0 | 57 | 71 | 3 | 0 | 3 | 1 | 0 | 0 | 0 | 6 | 17 | 30 | 0.57 | 1 | 278 | 174 | 104 | 42 | 64 | 21 | 4 | 8 | 1 |
| Chris Spurling | 9 | 0 | 0 | 0 | 9 | 11.3 | 6.9 | 0 | 0 | 17 | 7 | 33 | 15 | 45.5 | 45 | 49 | 3 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 16 | 25 | 0.64 | 2 | 169 | 112 | 57 | 33 | 28 | 10 | 1 | 3 | 0 |
| Jordan Tata | 8 | 0 | 0 | 0 | 8 | 14.7 | 6.1 | 0 | 0 | 4 | 0 | 6 | 0 | 0.0 | 56 | 65 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 23 | 29 | 0.79 | 1 | 236 | 136 | 100 | 42 | 29 | 13 | 1 | 5 | 1 |
| Justin Verlander | 30 | 30 | 18 | 186 | 0 | 0 | -- | 0 | 0 | 0 | 0 | 0 | 0 | -- | 703 | 776 | 33 | 4 | 6 | 1 | 1 | 2 | 11 | 78 | 248 | 335 | 0.74 | 21 | 2951 | 1844 | 1107 | 541 | 488 | 230 | 30 | 94 | 11 |
| Jamie Walker | 56 | 0 | 0 | 0 | 56 | 48 | 7.2 | 11 | 3 | 35 | 7 | 72 | 16 | 22.2 | 187 | 196 | 11 | 1 | 0 | 3 | 2 | 1 | 0 | 37 | 51 | 100 | 0.51 | 3 | 689 | 454 | 235 | 115 | 108 | 80 | 2 | 35 | 1 |
| Joel Zumaya | 62 | 0 | 0 | 0 | 62 | 83.3 | 7.1 | 28 | 5 | 47 | 13 | 99 | 27 | 27.3 | 300 | 350 | 3 | 2 | 2 | 2 | 4 | 0 | 0 | 9 | 73 | 136 | 0.54 | 1 | 1425 | 892 | 533 | 282 | 213 | 188 | 23 | 74 | 5 |