| 38 | Jeremy Bonderman | - | 8 | 34 | 34 | 214.0 | 4.08 | 1.30 | 9.00 | 0.76 | 2.69 | 8.50 | 0.32 | 1.01 | 19 | 3 | 827 | .259 | 903 | 3.66 | 36.1 | 63.9 | 11.6 |
| 29 | Nate Robertson | - | 26 | 32 | 32 | 208.2 | 3.84 | 1.31 | 8.88 | 1.25 | 2.89 | 5.91 | 0.49 | 0.92 | 20 | 8 | 795 | .259 | 881 | 3.53 | 37.8 | 62.2 | 8.4 |
| 37 | Kenny Rogers | - | 14 | 34 | 33 | 204.0 | 3.84 | 1.26 | 8.60 | 1.01 | 2.74 | 4.37 | 0.63 | 1.00 | 19 | 9 | 770 | .253 | 849 | 3.67 | 38.5 | 61.5 | 6.5 |
| 35 | Justin Verlander | - | 27 | 30 | 30 | 186.0 | 3.63 | 1.33 | 9.05 | 1.02 | 2.90 | 6.00 | 0.48 | 0.74 | 18 | 6 | 703 | .266 | 776 | 3.80 | 37.5 | 62.5 | 7.8 |
| 31 | Zach Miner | - | - | 27 | 16 | 93.0 | 4.84 | 1.42 | 9.68 | 1.06 | 3.10 | 5.71 | 0.54 | 0.97 | 6 | 0 | 362 | .276 | 398 | 4.13 | 39.9 | 60.1 | 8.3 |
| 54 | Joel Zumaya | - | - | 62 | 0 | 83.1 | 1.94 | 1.18 | 6.05 | 0.65 | 4.54 | 10.48 | 0.43 | 0.54 | 0 | 2 | 300 | .187 | 350 | 4.07 | 37.4 | 62.6 | 13.2 |
| 56 | Fernando Rodney | - | 70 | 63 | 0 | 71.2 | 3.52 | 1.19 | 6.40 | 0.75 | 4.27 | 8.16 | 0.52 | 1.40 | 0 | 8 | 260 | .196 | 304 | 3.97 | 39.3 | 60.7 | 11.7 |
| 59 | Todd Jones | - | 42 | 62 | 0 | 64.0 | 3.94 | 1.27 | 9.84 | 0.56 | 1.55 | 3.94 | 0.39 | 1.25 | 0 | 3 | 254 | .276 | 272 | 3.43 | 30.9 | 69.1 | 5.8 |
| 49 | Jason Grilli | - | - | 51 | 0 | 62.0 | 4.21 | 1.39 | 8.85 | 0.87 | 3.63 | 4.50 | 0.81 | 0.95 | 0 | 5 | 234 | .261 | 270 | 3.59 | 37.8 | 62.2 | 6.2 |
| 41 | Wil Ledezma | - | - | 24 | 7 | 60.1 | 3.58 | 1.38 | 8.95 | 0.75 | 3.43 | 5.82 | 0.59 | 0.57 | 1 | 2 | 236 | .254 | 264 | 3.59 | 36.9 | 63.1 | 7.5 |
| 46 | Mike Maroth | - | - | 13 | 9 | 53.2 | 4.19 | 1.49 | 10.73 | 1.84 | 2.68 | 4.02 | 0.67 | 0.72 | 5 | 1 | 217 | .295 | 234 | 3.68 | 41.3 | 58.7 | 5.2 |
| 32 | Jamie Walker | - | - | 56 | 0 | 48.0 | 2.81 | 1.15 | 8.81 | 1.50 | 1.50 | 6.94 | 0.22 | 0.51 | 0 | 0 | 187 | .251 | 196 | 3.52 | 34.1 | 65.9 | 11.6 |
| 43 | Roman Colon | - | - | 20 | 1 | 38.2 | 4.89 | 1.55 | 10.71 | 1.40 | 3.26 | 5.82 | 0.56 | 0.73 | 0 | 1 | 152 | .303 | 170 | 3.48 | 37.9 | 62.1 | 10.5 |
| 44 | Bobby Seay | - | - | 14 | 0 | 15.1 | 6.46 | 1.50 | 8.22 | 0.59 | 5.28 | 7.04 | 0.75 | 0.57 | 0 | 3 | 57 | .246 | 71 | 3.92 | 37.4 | 62.6 | 7.6 |
| 53 | Jordan Tata | - | - | 8 | 0 | 14.2 | 6.14 | 1.43 | 8.59 | 0.61 | 4.30 | 3.68 | 1.17 | 0.79 | 0 | 0 | 56 | .250 | 65 | 3.63 | 42.4 | 57.6 | 5.5 |
| 48 | Chris Spurling | - | - | 9 | 0 | 11.1 | 3.18 | 1.50 | 10.32 | 1.59 | 3.18 | 3.18 | 1.00 | 0.64 | 0 | 0 | 45 | .289 | 49 | 3.45 | 33.7 | 66.3 | 5.9 |
| 50 | Andrew Miller | - | - | 8 | 0 | 10.1 | 6.10 | 1.74 | 6.97 | -- | 8.71 | 5.23 | 1.67 | 2.30 | 0 | 2 | 39 | .205 | 51 | 3.76 | 44.8 | 55.2 | 6.8 |
| 52 | Chad Durbin | - | - | 3 | 0 | 6.0 | 1.50 | 1.00 | 9.00 | 1.50 | 0.00 | 4.50 | 0.00 | 0.62 | 0 | 0 | 24 | .250 | 24 | 3.38 | 32.1 | 67.9 | 3.7 |
| 36 | Colby Lewis | - | - | 2 | 0 | 3.0 | 3.00 | 3.00 | 24.00 | 3.00 | 3.00 | 15.00 | 0.20 | 1.40 | 0 | 0 | 17 | .471 | 18 | 4.00 | 36.1 | 63.9 | 6.9 |