| 2005-04-04 | @ ARI | 1 | W 16-6 | 1-0 | 1 | 45,539 | Carlos Zambrano | Javier Vazquez | Glendon Rusch | Javier Vazquez | | 16 | 6 | 10 |
| 2005-04-05 | @ ARI | 2 | L 4-5 | 1-1 | 4 | 30,260 | Greg Maddux | Russ Ortiz | Russ Ortiz | Greg Maddux | Brandon Lyon | 20 | 11 | 9 |
| 2005-04-06 | @ ARI | 3 | L 3-8 | 1-2 | 5 | 26,789 | Ryan Dempster | Brandon Webb | Brandon Webb | Ryan Dempster | | 23 | 19 | 4 |
| 2005-04-08 | vs MIL | 4 | L 3-6 | 1-3 | 5 | 39,892 | Kerry Wood | Chris Capuano | Jorge de la Rosa | Jon Leicester | Mike Adams | 26 | 25 | 1 |
| 2005-04-09 | vs MIL | 5 | W 4-0 | 2-3 | 5 | 38,743 | Carlos Zambrano | Ben Sheets | Carlos Zambrano | Ben Sheets | | 30 | 25 | 5 |
| 2005-04-10 | vs MIL | 6 | W 6-5 | 3-3 | 3 | 39,076 | Greg Maddux | Victor Santos | Glendon Rusch | Derrick Turnbow | | 36 | 30 | 6 |
| 2005-04-11 | vs SDN | 7 | L 0-1 | 3-4 | 4 | 36,791 | Ryan Dempster | Adam Eaton | Adam Eaton | Ryan Dempster | Trevor Hoffman | 36 | 31 | 5 |
| 2005-04-13 | vs SDN | 8 | L 3-8 | 4-5 | 4 | 0 | Kerry Wood | Jake Peavy | Jake Peavy | Kerry Wood | | 39 | 39 | 0 |
| 2005-04-13 | vs SDN | 9 | W 8-3 | 4-5 | 4 | 39,230 | Mark Prior | Brian Lawrence | Mark Prior | Brian Lawrence | | 47 | 42 | 5 |
| 2005-04-15 | @ PIT | 10 | L 5-8 | 4-6 | 5 | 29,256 | Carlos Zambrano | Oliver Perez | Salomon Torres | Mike Remlinger | Jose Mesa | 52 | 50 | 2 |
| 2005-04-16 | @ PIT | 11 | W 4-3 | 5-6 | 5 | 34,783 | Ryan Dempster | Kip Wells | Ryan Dempster | Kip Wells | LaTroy Hawkins | 56 | 53 | 3 |
| 2005-04-17 | @ PIT | 12 | W 4-2 | 6-6 | 3 | 20,416 | Greg Maddux | Mark Redman | Michael Wuertz | Mark Redman | LaTroy Hawkins | 60 | 55 | 5 |
| 2005-04-18 | @ CIN | 13 | L 6-7 | 6-7 | 3 | 25,349 | Kerry Wood | Matt Belisle | Kent Mercker | Jon Leicester | Danny Graves | 66 | 62 | 4 |
| 2005-04-19 | @ CIN | 14 | W 7-1 | 7-7 | 3 | 25,373 | Mark Prior | Brandon Claussen | Mark Prior | Brandon Claussen | | 73 | 63 | 10 |
| 2005-04-20 | @ SLN | 15 | W 3-1 | 8-7 | 3 | 44,855 | Carlos Zambrano | Jeff Suppan | Carlos Zambrano | Jeff Suppan | LaTroy Hawkins | 76 | 64 | 12 |
| 2005-04-21 | @ SLN | 16 | L 0-4 | 8-8 | 4 | 46,119 | Ryan Dempster | Chris Carpenter | Chris Carpenter | Ryan Dempster | | 76 | 68 | 8 |
| 2005-04-23 | vs PIT | 17 | L 3-4 | 8-9 | 2 | 37,695 | Greg Maddux | Mark Redman | John Grabow | LaTroy Hawkins | Jose Mesa | 79 | 72 | 7 |
| 2005-04-24 | vs PIT | 18 | W 5-2 | 9-9 | 2 | 37,452 | Kerry Wood | David Williams | Kerry Wood | David Williams | Chad Fox | 84 | 74 | 10 |
| 2005-04-25 | vs CIN | 19 | W 10-6 | 10-9 | 2 | 38,013 | Mark Prior | Paul Wilson | Mark Prior | Paul Wilson | | 94 | 80 | 14 |
| 2005-04-26 | vs CIN | 20 | L 9-11 | 10-10 | 2 | 38,113 | Carlos Zambrano | Eric Milton | David Weathers | Michael Wuertz | Danny Graves | 103 | 91 | 12 |
| 2005-04-27 | vs CIN | 21 | W 8-7 | 11-10 | 2 | 38,114 | Ryan Dempster | Aaron Harang | LaTroy Hawkins | Matt Belisle | | 111 | 98 | 13 |
| 2005-04-29 | @ HOU | 22 | W 3-2 | 12-10 | 2 | 41,232 | Greg Maddux | Roger Clemens | Greg Maddux | Roger Clemens | LaTroy Hawkins | 114 | 100 | 14 |
| 2005-04-30 | @ HOU | 23 | L 5-7 | 12-11 | 2 | 41,615 | Kerry Wood | Brandon Backe | Brandon Backe | Cliff Bartosh | | 119 | 107 | 12 |
| 2005-05-01 | @ HOU | 24 | L 3-9 | 12-12 | 2 | 38,014 | Mark Prior | Roy Oswalt | Roy Oswalt | Mark Prior | | 122 | 116 | 6 |
| 2005-05-03 | @ MIL | 25 | L 1-4 | 12-13 | 2 | 27,079 | Carlos Zambrano | Chris Capuano | Chris Capuano | Carlos Zambrano | Derrick Turnbow | 123 | 120 | 3 |
| 2005-05-04 | @ MIL | 26 | L 3-4 | 12-14 | 3 | 28,392 | Ryan Dempster | Victor Santos | Derrick Turnbow | Roberto Novoa | | 126 | 124 | 2 |
| 2005-05-05 | @ MIL | 27 | L 5-6 | 12-15 | 3 | 31,721 | Greg Maddux | Gary Glover | Derrick Turnbow | LaTroy Hawkins | | 131 | 130 | 1 |
| 2005-05-06 | vs PHI | 28 | L 2-3 | 12-16 | 3 | 38,767 | Mark Prior | Cory Lidle | Billy Wagner | LaTroy Hawkins | | 133 | 133 | 0 |
| 2005-05-07 | vs PHI | 29 | L 1-4 | 12-17 | 3 | 38,933 | Glendon Rusch | Jon Lieber | Jon Lieber | Glendon Rusch | Billy Wagner | 134 | 137 | -3 |
| 2005-05-08 | vs PHI | 30 | W 2-1 | 13-17 | 3 | 38,656 | Carlos Zambrano | Brett Myers | Carlos Zambrano | Brett Myers | | 136 | 138 | -2 |
| 2005-05-09 | vs NYN | 31 | L 4-7 | 13-18 | 3 | 37,562 | Jon Leicester | Aaron Heilman | Mike DeJean | LaTroy Hawkins | Braden Looper | 140 | 145 | -5 |
| 2005-05-10 | vs NYN | 32 | W 7-0 | 14-18 | 3 | 38,813 | Greg Maddux | Kris Benson | Greg Maddux | Kris Benson | | 147 | 145 | 2 |
| 2005-05-11 | vs NYN | 33 | W 4-3 | 15-18 | 3 | 38,475 | Mark Prior | Victor Zambrano | Ryan Dempster | Heath Bell | | 151 | 148 | 3 |
| 2005-05-13 | @ WAS | 34 | W 6-3 | 16-18 | 3 | 36,585 | Glendon Rusch | Esteban Loaiza | Will Ohman | Luis Ayala | Todd Wellemeyer | 157 | 151 | 6 |
| 2005-05-14 | @ WAS | 35 | L 3-4 | 16-19 | 3 | 42,829 | Carlos Zambrano | Livan Hernandez | Livan Hernandez | Carlos Zambrano | Chad Cordero | 160 | 155 | 5 |
| 2005-05-15 | @ WAS | 36 | L 4-5 | 16-20 | 4 | 44,103 | Greg Maddux | John Patterson | Hector Carrasco | Cliff Bartosh | Chad Cordero | 164 | 160 | 4 |
| 2005-05-17 | @ PIT | 37 | W 4-3 | 17-20 | 3 | 19,701 | Mark Prior | Josh Fogg | Will Ohman | Jose Mesa | Ryan Dempster | 168 | 163 | 5 |
| 2005-05-18 | @ PIT | 38 | W 3-2 | 18-20 | 3 | 21,142 | Glendon Rusch | Kip Wells | Michael Wuertz | Jose Mesa | Ryan Dempster | 171 | 165 | 6 |
| 2005-05-20 | vs CHA | 39 | L 1-5 | 18-21 | 3 | 38,988 | Greg Maddux | Freddy Garcia | Freddy Garcia | Greg Maddux | | 172 | 170 | 2 |
| 2005-05-21 | vs CHA | 40 | L 3-5 | 18-22 | 4 | 39,461 | Carlos Zambrano | Jose Contreras | Jose Contreras | Michael Wuertz | Dustin Hermanson | 175 | 175 | 0 |
| 2005-05-22 | vs CHA | 41 | W 4-3 | 19-22 | 3 | 39,334 | Mark Prior | Brandon McCarthy | Mark Prior | Luis Vizcaino | | 179 | 178 | 1 |
| 2005-05-23 | vs HOU | 42 | W 4-1 | 20-22 | 3 | 38,232 | Glendon Rusch | Wandy Rodriguez | Glendon Rusch | Wandy Rodriguez | Ryan Dempster | 183 | 179 | 4 |
| 2005-05-24 | vs HOU | 43 | W 4-2 | 21-22 | 3 | 38,805 | Sergio Mitre | Roger Clemens | Michael Wuertz | Brad Lidge | Ryan Dempster | 187 | 181 | 6 |
| 2005-05-25 | vs HOU | 44 | L 1-5 | 21-23 | 3 | 38,118 | Greg Maddux | Brandon Backe | Brandon Backe | Greg Maddux | | 188 | 186 | 2 |
| 2005-05-26 | vs COL | 45 | L 2-5 | 21-24 | 3 | 38,393 | Carlos Zambrano | Jason Jennings | Jason Jennings | Carlos Zambrano | | 190 | 191 | -1 |
| 2005-05-27 | vs COL | 46 | W 10-3 | 22-24 | 3 | 38,771 | Mark Prior | Joe Kennedy | Todd Wellemeyer | Joe Kennedy | | 200 | 194 | 6 |
| 2005-05-28 | vs COL | 47 | W 5-1 | 23-24 | 3 | 39,368 | Glendon Rusch | Byung-Hyun Kim | Glendon Rusch | Byung-Hyun Kim | | 205 | 195 | 10 |
| 2005-05-29 | vs COL | 48 | W 11-6 | 24-24 | 2 | 40,322 | Sergio Mitre | Jeff Francis | Roberto Novoa | Marcos Carvajal | | 216 | 201 | 15 |
| 2005-05-30 | @ LAN | 49 | W 5-3 | 25-24 | 2 | 44,255 | Greg Maddux | Wilson Alvarez | Greg Maddux | Wilson Alvarez | Ryan Dempster | 221 | 204 | 17 |
| 2005-05-31 | @ LAN | 50 | W 2-1 | 26-24 | 2 | 37,221 | Carlos Zambrano | Brad Penny | Michael Wuertz | Yhency Brazoban | Ryan Dempster | 223 | 205 | 18 |
| 2005-06-01 | @ LAN | 51 | W 9-5 | 27-24 | 2 | 54,093 | John Koronka | Derek Lowe | John Koronka | Derek Lowe | | 232 | 210 | 22 |
| 2005-06-02 | @ SDN | 52 | W 5-0 | 28-24 | 2 | 30,344 | Glendon Rusch | Tim Stauffer | Glendon Rusch | Tim Stauffer | | 237 | 210 | 27 |
| 2005-06-03 | @ SDN | 53 | L 2-6 | 28-25 | 2 | 41,158 | Sergio Mitre | Adam Eaton | Adam Eaton | Sergio Mitre | Akinori Otsuka | 239 | 216 | 23 |
| 2005-06-04 | @ SDN | 54 | W 11-5 | 29-25 | 2 | 43,876 | Greg Maddux | Darrell May | Greg Maddux | Darrell May | | 250 | 221 | 29 |
| 2005-06-05 | @ SDN | 55 | W 4-0 | 30-25 | 2 | 40,384 | Carlos Zambrano | Woody Williams | Carlos Zambrano | Woody Williams | | 254 | 221 | 33 |
| 2005-06-06 | vs TOR | 56 | L 1-4 | 30-26 | 2 | 38,807 | John Koronka | Gustavo Chacin | Gustavo Chacin | John Koronka | Miguel Batista | 255 | 225 | 30 |
| 2005-06-07 | vs TOR | 57 | L 4-6 | 30-27 | 2 | 39,159 | Glendon Rusch | Josh Towers | Scott Schoeneweis | Todd Wellemeyer | Miguel Batista | 259 | 231 | 28 |
| 2005-06-08 | vs TOR | 58 | W 2-0 | 31-27 | 2 | 38,086 | Sergio Mitre | Roy Halladay | Sergio Mitre | Roy Halladay | Ryan Dempster | 261 | 231 | 30 |
| 2005-06-10 | vs BOS | 59 | W 14-6 | 32-27 | 2 | 39,215 | Greg Maddux | Bronson Arroyo | Greg Maddux | Bronson Arroyo | | 275 | 237 | 38 |
| 2005-06-11 | vs BOS | 60 | W 7-6 | 33-27 | 2 | 39,096 | Carlos Zambrano | Wade Miller | Todd Wellemeyer | Wade Miller | Ryan Dempster | 282 | 243 | 39 |
| 2005-06-12 | vs BOS | 61 | L 1-8 | 33-28 | 2 | 39,138 | Glendon Rusch | Tim Wakefield | Tim Wakefield | Glendon Rusch | | 283 | 251 | 32 |
| 2005-06-13 | vs FLO | 62 | L 1-9 | 33-29 | 2 | 38,708 | John Koronka | Dontrelle Willis | Dontrelle Willis | John Koronka | | 284 | 260 | 24 |
| 2005-06-14 | vs FLO | 63 | W 14-0 | 34-29 | 2 | 38,887 | Sergio Mitre | Josh Beckett | Sergio Mitre | Josh Beckett | | 298 | 260 | 38 |
| 2005-06-15 | vs FLO | 64 | L 5-15 | 34-30 | 2 | 39,263 | Greg Maddux | A.J. Burnett | A.J. Burnett | Greg Maddux | | 303 | 275 | 28 |
| 2005-06-17 | @ NYA | 65 | L 6-9 | 34-31 | 2 | 54,773 | Carlos Zambrano | Carl Pavano | Mike Stanton | Will Ohman | Mariano Rivera | 309 | 284 | 25 |
| 2005-06-18 | @ NYA | 66 | L 1-8 | 34-32 | 2 | 55,284 | Glendon Rusch | Chien-Ming Wang | Chien-Ming Wang | Glendon Rusch | | 310 | 292 | 18 |
| 2005-06-19 | @ NYA | 67 | L 3-6 | 34-33 | 2 | 55,060 | Sergio Mitre | Mike Mussina | Mike Mussina | Sergio Mitre | Mariano Rivera | 313 | 298 | 15 |
| 2005-06-20 | @ MIL | 68 | W 5-4 | 35-33 | 2 | 40,126 | Greg Maddux | Tomo Ohka | Greg Maddux | Tomo Ohka | Ryan Dempster | 318 | 302 | 16 |
| 2005-06-21 | @ MIL | 69 | W 4-2 | 36-33 | 2 | 40,300 | Jerome Williams | Victor Santos | Jerome Williams | Victor Santos | Ryan Dempster | 322 | 304 | 18 |
| 2005-06-22 | @ MIL | 70 | L 4-9 | 36-34 | 2 | 41,453 | Carlos Zambrano | Doug Davis | Doug Davis | Carlos Zambrano | | 326 | 313 | 13 |
| 2005-06-23 | @ MIL | 71 | L 7-8 | 36-35 | 2 | 42,288 | Glendon Rusch | Ben Sheets | Ricky Bottalico | Mike Remlinger | Derrick Turnbow | 333 | 321 | 12 |
| 2005-06-24 | @ CHA | 72 | L 2-12 | 36-36 | 2 | 39,610 | Sergio Mitre | Freddy Garcia | Freddy Garcia | Sergio Mitre | | 335 | 333 | 2 |
| 2005-06-25 | @ CHA | 73 | W 6-2 | 37-36 | 2 | 39,241 | Greg Maddux | Jose Contreras | Greg Maddux | Jose Contreras | | 341 | 335 | 6 |
| 2005-06-26 | @ CHA | 74 | W 2-0 | 38-36 | 2 | 39,143 | Mark Prior | Jon Garland | Mark Prior | Jon Garland | Ryan Dempster | 343 | 335 | 8 |
| 2005-06-28 | vs MIL | 75 | W 2-0 | 39-36 | 2 | 39,574 | Carlos Zambrano | Doug Davis | Carlos Zambrano | Doug Davis | Ryan Dempster | 345 | 335 | 10 |
| 2005-06-29 | vs MIL | 76 | W 3-2 | 40-36 | 2 | 38,846 | Kerry Wood | Ben Sheets | Roberto Novoa | Julio Santana | | 348 | 337 | 11 |
| 2005-06-30 | vs MIL | 77 | L 6-10 | 40-37 | 2 | 38,631 | Greg Maddux | Chris Capuano | Chris Capuano | Greg Maddux | | 354 | 347 | 7 |
| 2005-07-01 | vs WAS | 78 | L 3-4 | 40-38 | 2 | 38,973 | Mark Prior | Livan Hernandez | Livan Hernandez | Mark Prior | Hector Carrasco | 357 | 351 | 6 |
| 2005-07-02 | vs WAS | 79 | L 2-4 | 40-39 | 2 | 40,488 | Jerome Williams | Tony Armas | Tony Armas | Jerome Williams | Chad Cordero | 359 | 355 | 4 |
| 2005-07-03 | vs WAS | 80 | L 4-5 | 40-40 | 2 | 40,006 | Carlos Zambrano | Ryan Drese | Joey Eischen | Sergio Mitre | | 363 | 360 | 3 |
| 2005-07-04 | @ ATL | 81 | L 0-4 | 40-41 | 2 | 52,274 | Kerry Wood | Kyle Davies | Kyle Davies | Kerry Wood | | 363 | 364 | -1 |
| 2005-07-05 | @ ATL | 82 | L 1-5 | 40-42 | 2 | 34,698 | Greg Maddux | Roman Colon | Roman Colon | Greg Maddux | | 364 | 369 | -5 |
| 2005-07-07 | @ ATL | 83 | L 0-6 | 40-44 | 3 | 32,711 | Mark Prior | Horacio Ramirez | Horacio Ramirez | Mark Prior | | 364 | 375 | -11 |
| 2005-07-07 | @ ATL | 84 | L 4-9 | 40-44 | 3 | 34,847 | Jerome Williams | John Smoltz | John Foster | Roberto Novoa | | 368 | 384 | -16 |
| 2005-07-08 | @ FLO | 85 | W 9-6 | 41-44 | 3 | 17,897 | Carlos Zambrano | Dontrelle Willis | Carlos Zambrano | Dontrelle Willis | Ryan Dempster | 377 | 390 | -13 |
| 2005-07-09 | @ FLO | 86 | W 8-2 | 42-44 | 3 | 22,863 | Kerry Wood | Scott Olsen | Kerry Wood | Guillermo Mota | | 385 | 392 | -7 |
| 2005-07-10 | @ FLO | 87 | W 9-2 | 43-44 | 3 | 20,267 | Greg Maddux | Al Leiter | Greg Maddux | Al Leiter | | 394 | 394 | 0 |
| 2005-07-14 | vs PIT | 88 | W 5-1 | 44-44 | 2 | 38,902 | Mark Prior | Mark Redman | Mark Prior | Mark Redman | | 399 | 395 | 4 |
| 2005-07-15 | vs PIT | 89 | W 11-1 | 45-44 | 2 | 39,512 | Kerry Wood | Josh Fogg | Kerry Wood | Josh Fogg | | 410 | 396 | 14 |
| 2005-07-16 | vs PIT | 90 | L 0-3 | 45-45 | 2 | 39,790 | Greg Maddux | Zach Duke | Zach Duke | Greg Maddux | Jose Mesa | 410 | 399 | 11 |
| 2005-07-17 | vs PIT | 91 | W 8-2 | 46-45 | 2 | 39,391 | Carlos Zambrano | Kip Wells | Carlos Zambrano | Kip Wells | | 418 | 401 | 17 |
| 2005-07-18 | @ CIN | 92 | W 9-4 | 47-45 | 2 | 24,311 | Jerome Williams | Brandon Claussen | Jerome Williams | Brandon Claussen | | 427 | 405 | 22 |
| 2005-07-19 | @ CIN | 93 | W 7-3 | 48-45 | 2 | 24,664 | Mark Prior | Luke Hudson | Mark Prior | Luke Hudson | | 434 | 408 | 26 |
| 2005-07-20 | @ CIN | 94 | L 3-9 | 48-46 | 2 | 27,363 | Kerry Wood | Aaron Harang | Aaron Harang | Kerry Wood | | 437 | 417 | 20 |
| 2005-07-21 | @ CIN | 95 | L 6-9 | 48-47 | 3 | 36,498 | Greg Maddux | Eric Milton | Brian Shackelford | Roberto Novoa | | 443 | 426 | 17 |
| 2005-07-22 | @ SLN | 96 | L 1-2 | 48-48 | 3 | 49,840 | Carlos Zambrano | Chris Carpenter | Alberto Reyes | Sergio Mitre | | 444 | 428 | 16 |
| 2005-07-23 | @ SLN | 97 | W 6-5 | 49-48 | 3 | 49,942 | Jerome Williams | Matt Morris | Jerome Williams | Matt Morris | Ryan Dempster | 450 | 433 | 17 |
| 2005-07-24 | @ SLN | 98 | W 8-4 | 50-48 | 3 | 49,762 | Mark Prior | Jeff Suppan | Ryan Dempster | Alberto Reyes | | 458 | 437 | 21 |
| 2005-07-25 | vs SFN | 99 | W 3-2 | 51-48 | 3 | 39,477 | Rich Hill | Jason Schmidt | Ryan Dempster | Tyler Walker | | 461 | 439 | 22 |
| 2005-07-26 | vs SFN | 100 | L 2-3 | 51-49 | 3 | 39,002 | Greg Maddux | Noah Lowry | Jason Christiansen | Glendon Rusch | Tyler Walker | 463 | 442 | 21 |
| 2005-07-27 | vs SFN | 101 | W 4-3 | 52-49 | 3 | 38,877 | Carlos Zambrano | Brett Tomko | Ryan Dempster | Kevin Correia | | 467 | 445 | 22 |
| 2005-07-28 | vs ARI | 102 | L 0-6 | 52-50 | 3 | 39,154 | Jerome Williams | Brad Halsey | Brad Halsey | Jerome Williams | | 467 | 451 | 16 |
| 2005-07-29 | vs ARI | 103 | W 4-3 | 53-50 | 3 | 39,312 | Mark Prior | Javier Vazquez | Roberto Novoa | Brian Bruney | | 471 | 454 | 17 |
| 2005-07-30 | vs ARI | 104 | L 2-3 | 53-51 | 3 | 39,726 | Rich Hill | Mike Gosling | Lance Cormier | Roberto Novoa | Greg Aquino | 473 | 457 | 16 |
| 2005-07-31 | vs ARI | 105 | L 6-13 | 53-52 | 3 | 39,285 | Greg Maddux | Brandon Webb | Brandon Webb | Greg Maddux | | 479 | 470 | 9 |
| 2005-08-02 | @ PHI | 106 | W 2-1 | 54-52 | 3 | 32,585 | Carlos Zambrano | Vicente Padilla | Carlos Zambrano | Vicente Padilla | Ryan Dempster | 481 | 471 | 10 |
| 2005-08-03 | @ PHI | 107 | L 3-4 | 54-53 | 3 | 34,727 | Jerome Williams | Rob Tejeda | Billy Wagner | Mike Remlinger | | 484 | 475 | 9 |
| 2005-08-04 | @ PHI | 108 | L 4-6 | 54-54 | 3 | 37,882 | Mark Prior | Brett Myers | Brett Myers | Mark Prior | Billy Wagner | 488 | 481 | 7 |
| 2005-08-05 | @ NYN | 109 | L 5-9 | 54-55 | 4 | 34,728 | Rich Hill | Tom Glavine | Tom Glavine | Rich Hill | | 493 | 490 | 3 |
| 2005-08-06 | @ NYN | 110 | L 0-2 | 54-56 | 4 | 39,911 | Greg Maddux | Jae Weong Seo | Jae Weong Seo | Greg Maddux | Braden Looper | 493 | 492 | 1 |
| 2005-08-07 | @ NYN | 111 | L 1-6 | 54-57 | 4 | 40,321 | Carlos Zambrano | Victor Zambrano | Victor Zambrano | Carlos Zambrano | | 494 | 498 | -4 |
| 2005-08-08 | vs CIN | 112 | L 4-9 | 54-58 | 4 | 39,965 | Jerome Williams | Brandon Claussen | Brandon Claussen | Jerome Williams | | 498 | 507 | -9 |
| 2005-08-09 | vs CIN | 113 | L 3-8 | 54-59 | 4 | 38,368 | Mark Prior | Aaron Harang | Aaron Harang | Will Ohman | | 501 | 515 | -14 |
| 2005-08-10 | vs CIN | 114 | L 2-8 | 54-60 | 4 | 38,405 | Rich Hill | Eric Milton | Eric Milton | Rich Hill | | 503 | 523 | -20 |
| 2005-08-11 | vs SLN | 115 | W 11-4 | 55-60 | 4 | 38,170 | Greg Maddux | Mark Mulder | Greg Maddux | Mark Mulder | | 514 | 527 | -13 |
| 2005-08-12 | vs SLN | 116 | W 4-1 | 56-60 | 3 | 39,717 | Carlos Zambrano | Jason Marquis | Carlos Zambrano | Jason Marquis | | 518 | 528 | -10 |
| 2005-08-13 | vs SLN | 117 | L 2-5 | 56-61 | 3 | 39,923 | Jerome Williams | Chris Carpenter | Chris Carpenter | Jerome Williams | | 520 | 533 | -13 |
| 2005-08-14 | vs SLN | 118 | W 5-4 | 57-61 | 3 | 39,311 | Mark Prior | Matt Morris | Mark Prior | Matt Morris | Ryan Dempster | 525 | 537 | -12 |
| 2005-08-15 | @ HOU | 119 | L 4-12 | 57-62 | 3 | 26,992 | Glendon Rusch | Wandy Rodriguez | Wandy Rodriguez | Glendon Rusch | | 529 | 549 | -20 |
| 2005-08-16 | @ HOU | 120 | W 4-1 | 58-62 | 3 | 31,963 | Greg Maddux | Andy Pettitte | Greg Maddux | Andy Pettitte | Ryan Dempster | 533 | 550 | -17 |
| 2005-08-17 | @ HOU | 121 | W 4-2 | 59-62 | 3 | 29,978 | Carlos Zambrano | Roy Oswalt | Carlos Zambrano | Roy Oswalt | Ryan Dempster | 537 | 552 | -15 |
| 2005-08-19 | @ COL | 122 | W 5-3 | 60-62 | 3 | 30,175 | Mark Prior | Byung-Hyun Kim | Mark Prior | Byung-Hyun Kim | Ryan Dempster | 542 | 555 | -13 |
| 2005-08-20 | @ COL | 123 | L 2-4 | 60-63 | 4 | 35,787 | Glendon Rusch | Aaron Cook | Aaron Cook | Glendon Rusch | Brian Fuentes | 544 | 559 | -15 |
| 2005-08-21 | @ COL | 124 | L 7-9 | 60-64 | 4 | 30,111 | Greg Maddux | Jeff Francis | Sun-Woo Kim | Greg Maddux | | 551 | 568 | -17 |
| 2005-08-22 | vs ATL | 125 | L 2-4 | 60-65 | 4 | 38,767 | Carlos Zambrano | Tim Hudson | Tim Hudson | Kerry Wood | | 553 | 572 | -19 |
| 2005-08-23 | vs ATL | 126 | W 10-1 | 61-65 | 4 | 38,273 | Jerome Williams | John Thomson | Jerome Williams | John Thomson | | 563 | 573 | -10 |
| 2005-08-24 | vs ATL | 127 | L 1-3 | 61-66 | 4 | 38,033 | Mark Prior | Jorge Sosa | Jorge Sosa | Mark Prior | Kyle Farnsworth | 564 | 576 | -12 |
| 2005-08-26 | vs FLO | 128 | L 5-7 | 61-67 | 4 | 38,544 | Glendon Rusch | Jason Vargas | Jason Vargas | Glendon Rusch | Todd Jones | 569 | 583 | -14 |
| 2005-08-27 | vs FLO | 129 | L 1-2 | 61-68 | 5 | 39,202 | Greg Maddux | Dontrelle Willis | Dontrelle Willis | Greg Maddux | Todd Jones | 570 | 585 | -15 |
| 2005-08-28 | vs FLO | 130 | W 14-3 | 62-68 | 5 | 38,763 | Carlos Zambrano | Josh Beckett | Carlos Zambrano | Josh Beckett | | 584 | 588 | -4 |
| 2005-08-29 | vs LAN | 131 | L 6-9 | 62-69 | 5 | 37,625 | Jerome Williams | D.J. Houlton | D.J. Houlton | Jerome Williams | Duaner Sanchez | 590 | 597 | -7 |
| 2005-08-30 | vs LAN | 132 | W 6-3 | 63-69 | 4 | 37,552 | Mark Prior | Brad Penny | Mark Prior | Brad Penny | Ryan Dempster | 596 | 600 | -4 |
| 2005-08-31 | vs LAN | 133 | L 0-7 | 63-70 | 4 | 37,489 | Glendon Rusch | Derek Lowe | Derek Lowe | Glendon Rusch | | 596 | 607 | -11 |
| 2005-09-02 | @ PIT | 134 | W 7-3 | 64-70 | 4 | 24,976 | Greg Maddux | Josh Fogg | Greg Maddux | Josh Fogg | Ryan Dempster | 603 | 610 | -7 |
| 2005-09-03 | @ PIT | 135 | W 9-5 | 65-70 | 4 | 22,909 | Carlos Zambrano | David Williams | Carlos Zambrano | David Williams | | 612 | 615 | -3 |
| 2005-09-04 | @ PIT | 136 | W 2-0 | 66-70 | 4 | 23,204 | Jerome Williams | Kip Wells | Jerome Williams | Kip Wells | Ryan Dempster | 614 | 615 | -1 |
| 2005-09-05 | @ SLN | 137 | L 4-6 | 66-71 | 4 | 49,646 | Mark Prior | Jeff Suppan | Ray King | Roberto Novoa | Julian Tavarez | 618 | 621 | -3 |
| 2005-09-06 | @ SLN | 138 | W 5-2 | 67-71 | 4 | 47,292 | Glendon Rusch | Matt Morris | Glendon Rusch | Matt Morris | Ryan Dempster | 623 | 623 | 0 |
| 2005-09-07 | @ SLN | 139 | W 2-1 | 68-71 | 4 | 47,789 | Greg Maddux | Mark Mulder | Greg Maddux | Mark Mulder | Ryan Dempster | 625 | 624 | 1 |
| 2005-09-08 | @ SFN | 140 | W 5-3 | 69-71 | 3 | 37,042 | Carlos Zambrano | Noah Lowry | Carlos Zambrano | Noah Lowry | Ryan Dempster | 630 | 627 | 3 |
| 2005-09-09 | @ SFN | 141 | L 1-2 | 69-72 | 4 | 39,936 | Jerome Williams | Matt Cain | Matt Cain | Jerome Williams | | 631 | 629 | 2 |
| 2005-09-10 | @ SFN | 142 | W 5-2 | 70-72 | 3 | 42,013 | Mark Prior | Brad Hennessey | Mark Prior | Brad Hennessey | Ryan Dempster | 636 | 631 | 5 |
| 2005-09-11 | @ SFN | 143 | W 3-2 | 71-72 | 3 | 41,052 | Glendon Rusch | Brett Tomko | Michael Wuertz | LaTroy Hawkins | Ryan Dempster | 639 | 633 | 6 |
| 2005-09-12 | vs CIN | 144 | L 2-5 | 71-73 | 4 | 37,926 | Greg Maddux | Aaron Harang | Aaron Harang | Greg Maddux | David Weathers | 641 | 638 | 3 |
| 2005-09-13 | vs CIN | 145 | W 4-3 | 72-73 | 4 | 37,625 | Carlos Zambrano | Eric Milton | Michael Wuertz | David Weathers | | 645 | 641 | 4 |
| 2005-09-14 | vs CIN | 146 | L 4-7 | 72-74 | 4 | 37,695 | Jerome Williams | Randy Keisler | Todd Coffey | Jermaine Van Buren | | 649 | 648 | 1 |
| 2005-09-15 | vs SLN | 147 | L 1-6 | 72-75 | 4 | 37,849 | Mark Prior | Jeff Suppan | Jeff Suppan | Mark Prior | | 650 | 654 | -4 |
| 2005-09-16 | vs SLN | 148 | W 5-3 | 73-75 | 4 | 38,080 | Glendon Rusch | Matt Morris | Glendon Rusch | Matt Morris | Ryan Dempster | 655 | 657 | -2 |
| 2005-09-17 | vs SLN | 149 | L 1-5 | 73-76 | 4 | 39,269 | Greg Maddux | Mark Mulder | Mark Mulder | Greg Maddux | | 656 | 662 | -6 |
| 2005-09-18 | vs SLN | 150 | W 7-4 | 74-76 | 3 | 38,182 | Carlos Zambrano | Chris Carpenter | Carlos Zambrano | Anthony Reyes | | 663 | 666 | -3 |
| 2005-09-20 | @ MIL | 151 | L 3-5 | 74-77 | 4 | 30,136 | Jerome Williams | Doug Davis | Doug Davis | Jerome Williams | Derrick Turnbow | 666 | 671 | -5 |
| 2005-09-21 | @ MIL | 152 | L 6-7 | 74-78 | 4 | 30,049 | Mark Prior | Tomo Ohka | Derrick Turnbow | Jermaine Van Buren | | 672 | 678 | -6 |
| 2005-09-22 | @ MIL | 153 | W 3-0 | 75-78 | 4 | 31,137 | Greg Maddux | Rick Helling | Greg Maddux | Rick Helling | Ryan Dempster | 675 | 678 | -3 |
| 2005-09-23 | vs HOU | 154 | W 5-4 | 76-78 | 4 | 38,622 | Glendon Rusch | Wandy Rodriguez | Glendon Rusch | Wandy Rodriguez | Ryan Dempster | 680 | 682 | -2 |
| 2005-09-24 | vs HOU | 155 | L 3-8 | 76-79 | 4 | 39,263 | Carlos Zambrano | Ezequiel Astacio | Ezequiel Astacio | Carlos Zambrano | | 683 | 690 | -7 |
| 2005-09-25 | vs HOU | 156 | W 3-2 | 77-79 | 4 | 38,121 | Jerome Williams | Andy Pettitte | Jerome Williams | Mike Gallo | Ryan Dempster | 686 | 692 | -6 |
| 2005-09-27 | vs PIT | 157 | L 3-5 | 77-80 | 4 | 38,440 | Greg Maddux | Zach Duke | Zach Duke | Greg Maddux | Salomon Torres | 689 | 697 | -8 |
| 2005-09-28 | vs PIT | 158 | L 2-3 | 77-81 | 4 | 37,491 | Mark Prior | Paul Maholm | Paul Maholm | Mark Prior | Mike Gonzalez | 691 | 700 | -9 |
| 2005-09-29 | @ HOU | 159 | W 3-2 | 78-81 | 4 | 37,820 | Glendon Rusch | Wandy Rodriguez | Glendon Rusch | Wandy Rodriguez | Ryan Dempster | 694 | 702 | -8 |
| 2005-09-30 | @ HOU | 160 | W 4-3 | 79-81 | 4 | 41,304 | Carlos Zambrano | Andy Pettitte | Roberto Novoa | Brad Lidge | Ryan Dempster | 698 | 705 | -7 |
| 2005-10-01 | @ HOU | 161 | L 1-3 | 79-82 | 4 | 42,021 | Jerome Williams | Roger Clemens | Roger Clemens | Jerome Williams | Brad Lidge | 699 | 708 | -9 |
| 2005-10-02 | @ HOU | 162 | L 4-6 | 79-83 | 4 | 42,288 | Greg Maddux | Roy Oswalt | Roy Oswalt | Greg Maddux | Brad Lidge | 703 | 714 | -11 |