| 2005-04-04 | vs OAK | 1 | W 4-0 | 1-0 | 1 | 48,271 | Rodrigo Lopez | Barry Zito | Rodrigo Lopez | Barry Zito | | 4 | 0 | 4 |
| 2005-04-06 | vs OAK | 2 | L 0-9 | 1-1 | 3 | 22,415 | Daniel Cabrera | Kirk Saarloos | Kirk Saarloos | Daniel Cabrera | | 4 | 9 | -5 |
| 2005-04-07 | vs OAK | 3 | L 1-5 | 1-2 | 3 | 16,395 | Erik Bedard | Dan Haren | Ricardo Rincon | Steve Kline | | 5 | 14 | -9 |
| 2005-04-08 | @ NYA | 4 | W 12-5 | 2-2 | 1 | 43,128 | Sidney Ponson | Jaret Wright | Sidney Ponson | Jaret Wright | | 17 | 19 | -2 |
| 2005-04-09 | @ NYA | 5 | L 5-8 | 2-3 | 4 | 50,275 | Bruce Chen | Randy Johnson | Tanyon Sturtze | Steve Reed | Mariano Rivera | 22 | 27 | -5 |
| 2005-04-10 | @ NYA | 6 | W 7-2 | 3-3 | 2 | 46,797 | Rodrigo Lopez | Carl Pavano | Rodrigo Lopez | Carl Pavano | | 29 | 29 | 0 |
| 2005-04-12 | @ TBA | 7 | W 7-6 | 4-3 | 2 | 10,563 | Daniel Cabrera | Scott Kazmir | Todd Williams | Casey Fossum | B.J. Ryan | 36 | 35 | 1 |
| 2005-04-13 | @ TBA | 8 | W 5-1 | 5-3 | 2 | 9,226 | Erik Bedard | Mark Hendrickson | Steve Kline | Mark Hendrickson | | 41 | 36 | 5 |
| 2005-04-14 | @ TBA | 9 | L 7-12 | 5-4 | 2 | 9,797 | Sidney Ponson | Rob Bell | Rob Bell | Sidney Ponson | | 48 | 48 | 0 |
| 2005-04-15 | vs NYA | 10 | W 8-1 | 6-4 | 2 | 48,061 | Bruce Chen | Carl Pavano | Bruce Chen | Carl Pavano | | 56 | 49 | 7 |
| 2005-04-16 | vs NYA | 11 | W 7-6 | 7-4 | 2 | 48,598 | Rodrigo Lopez | Mike Mussina | Steve Kline | Tom Gordon | B.J. Ryan | 63 | 55 | 8 |
| 2005-04-17 | vs NYA | 12 | W 8-4 | 8-4 | 1 | 47,883 | Daniel Cabrera | Kevin Brown | Daniel Cabrera | Kevin Brown | | 71 | 59 | 12 |
| 2005-04-18 | vs DET | 13 | L 3-13 | 8-5 | 1 | 16,301 | Erik Bedard | Jason Johnson | Jason Johnson | Erik Bedard | | 74 | 72 | 2 |
| 2005-04-19 | vs DET | 14 | W 8-4 | 9-5 | 1 | 18,009 | Sidney Ponson | Nate Robertson | Sidney Ponson | Nate Robertson | | 82 | 76 | 6 |
| 2005-04-20 | vs BOS | 15 | L 0-8 | 9-6 | 1 | 36,478 | Bruce Chen | David Wells | David Wells | Bruce Chen | | 82 | 84 | -2 |
| 2005-04-21 | vs BOS | 16 | L 0-1 | 9-7 | 2 | 40,419 | Rodrigo Lopez | Matt Clement | Matt Clement | Rodrigo Lopez | Keith Foulke | 82 | 85 | -3 |
| 2005-04-22 | @ TOR | 17 | W 13-5 | 10-7 | 1 | 18,095 | Daniel Cabrera | Josh Towers | Todd Williams | Justin Speier | | 95 | 90 | 5 |
| 2005-04-23 | @ TOR | 18 | W 4-1 | 11-7 | 1 | 20,051 | Erik Bedard | David Bush | Erik Bedard | David Bush | | 99 | 91 | 8 |
| 2005-04-24 | @ TOR | 19 | W 7-1 | 12-7 | 1 | 20,566 | Sidney Ponson | Roy Halladay | Sidney Ponson | Roy Halladay | | 106 | 92 | 14 |
| 2005-04-25 | @ BOS | 20 | W 8-4 | 13-7 | 1 | 35,003 | Bruce Chen | David Wells | Bruce Chen | David Wells | | 114 | 96 | 18 |
| 2005-04-26 | @ BOS | 21 | W 11-8 | 14-7 | 1 | 35,670 | Rodrigo Lopez | Matt Clement | Jorge Julio | Keith Foulke | B.J. Ryan | 125 | 104 | 21 |
| 2005-04-29 | vs TBA | 22 | W 5-0 | 15-7 | 1 | 24,910 | Erik Bedard | Hideo Nomo | Erik Bedard | Hideo Nomo | | 130 | 104 | 26 |
| 2005-04-30 | vs TBA | 23 | W 7-5 | 16-7 | 1 | 19,920 | Sidney Ponson | Mark Hendrickson | Todd Williams | Travis Harper | B.J. Ryan | 137 | 109 | 28 |
| 2005-05-01 | vs TBA | 24 | W 7-4 | 17-7 | 1 | 30,784 | Bruce Chen | Dewon Brazelton | Bruce Chen | Dewon Brazelton | B.J. Ryan | 144 | 113 | 31 |
| 2005-05-02 | vs TOR | 25 | L 2-6 | 17-8 | 1 | 15,641 | Rodrigo Lopez | Gustavo Chacin | Scott Schoeneweis | Todd Williams | | 146 | 119 | 27 |
| 2005-05-03 | vs TOR | 26 | L 0-1 | 17-9 | 1 | 17,934 | Daniel Cabrera | Josh Towers | Josh Towers | Daniel Cabrera | Miguel Batista | 146 | 120 | 26 |
| 2005-05-04 | vs TOR | 27 | W 5-1 | 18-9 | 1 | 17,645 | Erik Bedard | Roy Halladay | Erik Bedard | Roy Halladay | | 151 | 121 | 30 |
| 2005-05-06 | vs KCA | 28 | W 3-1 | 19-9 | 1 | 30,568 | Sidney Ponson | Denny Bautista | Sidney Ponson | Denny Bautista | B.J. Ryan | 154 | 122 | 32 |
| 2005-05-07 | vs KCA | 29 | W 5-3 | 20-9 | 1 | 30,084 | Bruce Chen | Jose Lima | Bruce Chen | Jose Lima | B.J. Ryan | 159 | 125 | 34 |
| 2005-05-08 | vs KCA | 30 | L 8-10 | 20-10 | 1 | 35,252 | Rodrigo Lopez | Brian Anderson | Ambiorix Burgos | Todd Williams | | 167 | 135 | 32 |
| 2005-05-09 | vs MIN | 31 | W 3-0 | 21-10 | 1 | 17,310 | Daniel Cabrera | Carlos Silva | Daniel Cabrera | Carlos Silva | B.J. Ryan | 170 | 135 | 35 |
| 2005-05-10 | vs MIN | 32 | L 4-6 | 21-11 | 1 | 22,410 | Erik Bedard | Brad Radke | Jesse Crain | Steve Kline | Joe Nathan | 174 | 141 | 33 |
| 2005-05-11 | vs MIN | 33 | W 7-4 | 22-11 | 1 | 28,575 | Sidney Ponson | Johan Santana | Sidney Ponson | Matt Guerrier | B.J. Ryan | 181 | 145 | 36 |
| 2005-05-12 | @ CHA | 34 | L 2-3 | 22-12 | 1 | 29,031 | Bruce Chen | Jon Garland | Jon Garland | Bruce Chen | Dustin Hermanson | 183 | 148 | 35 |
| 2005-05-13 | @ CHA | 35 | L 3-5 | 22-13 | 1 | 28,188 | Rodrigo Lopez | Mark Buehrle | Mark Buehrle | Todd Williams | Dustin Hermanson | 186 | 153 | 33 |
| 2005-05-14 | @ CHA | 36 | W 9-6 | 23-13 | 1 | 37,311 | Daniel Cabrera | Freddy Garcia | Daniel Cabrera | Freddy Garcia | B.J. Ryan | 195 | 159 | 36 |
| 2005-05-15 | @ CHA | 37 | W 6-2 | 24-13 | 1 | 34,030 | Erik Bedard | Jose Contreras | Erik Bedard | Jose Contreras | | 201 | 161 | 40 |
| 2005-05-17 | @ KCA | 38 | W 12-8 | 25-13 | 1 | 13,274 | Sidney Ponson | Jose Lima | John Parrish | Jaime Cerda | B.J. Ryan | 213 | 169 | 44 |
| 2005-05-18 | @ KCA | 39 | W 7-4 | 26-13 | 1 | 10,375 | Bruce Chen | D.J. Carrasco | Bruce Chen | D.J. Carrasco | B.J. Ryan | 220 | 173 | 47 |
| 2005-05-19 | @ KCA | 40 | L 4-7 | 26-14 | 1 | 25,419 | Rodrigo Lopez | Runelvys Hernandez | Leo Nunez | Rodrigo Lopez | Mike MacDougal | 224 | 180 | 44 |
| 2005-05-20 | vs PHI | 41 | L 3-9 | 26-15 | 1 | 34,642 | Daniel Cabrera | Randy Wolf | Randy Wolf | Daniel Cabrera | | 227 | 189 | 38 |
| 2005-05-21 | vs PHI | 42 | W 7-0 | 27-15 | 1 | 42,331 | Erik Bedard | Vicente Padilla | Erik Bedard | Vicente Padilla | | 234 | 189 | 45 |
| 2005-05-22 | vs PHI | 43 | L 2-7 | 27-16 | 1 | 41,614 | Sidney Ponson | Cory Lidle | Cory Lidle | Sidney Ponson | | 236 | 196 | 40 |
| 2005-05-24 | vs SEA | 44 | W 3-2 | 28-16 | 1 | 19,839 | Bruce Chen | Joel Pineiro | Todd Williams | J.J. Putz | B.J. Ryan | 239 | 198 | 41 |
| 2005-05-25 | vs SEA | 45 | W 3-1 | 29-16 | 1 | 18,820 | Rodrigo Lopez | Jamie Moyer | Rodrigo Lopez | Jamie Moyer | B.J. Ryan | 242 | 199 | 43 |
| 2005-05-26 | vs SEA | 46 | W 5-2 | 30-16 | 1 | 22,166 | Daniel Cabrera | Ryan Franklin | Daniel Cabrera | Ryan Franklin | | 247 | 201 | 46 |
| 2005-05-27 | vs DET | 47 | L 3-4 | 30-17 | 1 | 34,175 | Sidney Ponson | Nate Robertson | Nate Robertson | Sidney Ponson | Ugueth Urbina | 250 | 205 | 45 |
| 2005-05-28 | vs DET | 48 | L 3-5 | 30-18 | 1 | 35,955 | Hayden Penn | Jason Johnson | Jason Johnson | Jorge Julio | Ugueth Urbina | 253 | 210 | 43 |
| 2005-05-29 | vs DET | 49 | L 6-8 | 30-19 | 1 | 37,061 | Bruce Chen | Wil Ledezma | Chris Spurling | Steve Reed | Ugueth Urbina | 259 | 218 | 41 |
| 2005-05-30 | @ BOS | 50 | W 8-1 | 31-19 | 1 | 35,483 | Rodrigo Lopez | Bronson Arroyo | Rodrigo Lopez | Bronson Arroyo | | 267 | 219 | 48 |
| 2005-05-31 | @ BOS | 51 | L 1-5 | 31-20 | 1 | 35,147 | Daniel Cabrera | Wade Miller | Wade Miller | Daniel Cabrera | | 268 | 224 | 44 |
| 2005-06-01 | @ BOS | 52 | W 9-3 | 32-20 | 1 | 35,527 | Sidney Ponson | Tim Wakefield | Sidney Ponson | Tim Wakefield | | 277 | 227 | 50 |
| 2005-06-02 | @ BOS | 53 | L 4-6 | 32-21 | 1 | 35,138 | Hayden Penn | Matt Clement | Keith Foulke | B.J. Ryan | | 281 | 233 | 48 |
| 2005-06-03 | @ DET | 54 | L 3-5 | 32-22 | 1 | 30,784 | Bruce Chen | Jason Johnson | Jason Johnson | Bruce Chen | Kyle Farnsworth | 284 | 238 | 46 |
| 2005-06-04 | @ DET | 55 | W 14-7 | 33-22 | 1 | 33,451 | Rodrigo Lopez | Wil Ledezma | Steve Reed | Jamie Walker | | 298 | 245 | 53 |
| 2005-06-05 | @ DET | 56 | W 6-2 | 34-22 | 1 | 28,252 | Daniel Cabrera | Mike Maroth | Daniel Cabrera | Mike Maroth | | 304 | 247 | 57 |
| 2005-06-06 | @ PIT | 57 | W 4-3 | 35-22 | 1 | 15,860 | Sidney Ponson | Josh Fogg | Jorge Julio | Salomon Torres | B.J. Ryan | 308 | 250 | 58 |
| 2005-06-07 | @ PIT | 58 | L 5-6 | 35-23 | 1 | 21,422 | Hayden Penn | David Williams | Brian Meadows | Jorge Julio | Jose Mesa | 313 | 256 | 57 |
| 2005-06-08 | @ PIT | 59 | L 1-6 | 35-24 | 1 | 37,438 | Bruce Chen | Kip Wells | Kip Wells | Bruce Chen | | 314 | 262 | 52 |
| 2005-06-10 | @ CIN | 60 | W 4-3 | 36-24 | 1 | 24,276 | Rodrigo Lopez | Aaron Harang | Rodrigo Lopez | Aaron Harang | B.J. Ryan | 318 | 265 | 53 |
| 2005-06-11 | @ CIN | 61 | L 1-10 | 36-25 | 1 | 32,834 | Daniel Cabrera | Brandon Claussen | Brandon Claussen | Daniel Cabrera | | 319 | 275 | 44 |
| 2005-06-12 | @ CIN | 62 | L 6-10 | 36-26 | 1 | 27,530 | Sidney Ponson | Ramon Ortiz | Ramon Ortiz | Sidney Ponson | | 325 | 285 | 40 |
| 2005-06-13 | vs HOU | 63 | W 8-5 | 37-26 | 1 | 23,297 | Hayden Penn | Brandon Backe | Hayden Penn | Brandon Backe | B.J. Ryan | 333 | 290 | 43 |
| 2005-06-14 | vs HOU | 64 | W 6-1 | 38-26 | 1 | 24,659 | Bruce Chen | Andy Pettitte | Bruce Chen | Andy Pettitte | | 339 | 291 | 48 |
| 2005-06-15 | vs HOU | 65 | W 5-1 | 39-26 | 1 | 31,547 | Rodrigo Lopez | Wandy Rodriguez | Rodrigo Lopez | Wandy Rodriguez | | 344 | 292 | 52 |
| 2005-06-17 | vs COL | 66 | L 1-2 | 39-27 | 1 | 49,004 | Daniel Cabrera | Jason Jennings | Jason Jennings | Daniel Cabrera | Brian Fuentes | 345 | 294 | 51 |
| 2005-06-18 | vs COL | 67 | W 7-2 | 40-27 | 1 | 43,067 | Sidney Ponson | Byung-Hyun Kim | Sidney Ponson | Byung-Hyun Kim | | 352 | 296 | 56 |
| 2005-06-19 | vs COL | 68 | W 4-2 | 41-27 | 1 | 45,945 | Hayden Penn | Jeff Francis | Hayden Penn | Jeff Francis | B.J. Ryan | 356 | 298 | 58 |
| 2005-06-20 | @ TOR | 69 | L 2-11 | 41-28 | 1 | 15,849 | Bruce Chen | Ted Lilly | Ted Lilly | Bruce Chen | | 358 | 309 | 49 |
| 2005-06-21 | @ TOR | 70 | W 9-5 | 42-28 | 1 | 17,884 | Rodrigo Lopez | Gustavo Chacin | Rodrigo Lopez | Gustavo Chacin | | 367 | 314 | 53 |
| 2005-06-22 | @ TOR | 71 | L 2-3 | 42-29 | 1 | 20,617 | Daniel Cabrera | Pete Walker | Pete Walker | Daniel Cabrera | Miguel Batista | 369 | 317 | 52 |
| 2005-06-23 | @ TOR | 72 | L 2-6 | 42-30 | 1 | 22,390 | Sidney Ponson | Roy Halladay | Roy Halladay | Sidney Ponson | | 371 | 323 | 48 |
| 2005-06-24 | @ ATL | 73 | L 5-7 | 42-31 | 2 | 43,822 | Hayden Penn | Kyle Davies | Kyle Davies | Hayden Penn | Chris Reitsma | 376 | 330 | 46 |
| 2005-06-25 | @ ATL | 74 | L 4-5 | 42-32 | 2 | 44,106 | Bruce Chen | Roman Colon | Jorge Vasquez | Todd Williams | | 380 | 335 | 45 |
| 2005-06-26 | @ ATL | 75 | L 1-8 | 42-33 | 2 | 37,157 | Rodrigo Lopez | John Smoltz | John Smoltz | Rodrigo Lopez | | 381 | 343 | 38 |
| 2005-06-27 | vs NYA | 76 | L 4-6 | 42-34 | 2 | 45,801 | Daniel Cabrera | Carl Pavano | Tanyon Sturtze | Steve Kline | Mariano Rivera | 385 | 349 | 36 |
| 2005-06-28 | vs NYA | 77 | W 5-4 | 43-34 | 2 | 47,465 | Sidney Ponson | Chien-Ming Wang | B.J. Ryan | Mike Stanton | | 390 | 353 | 37 |
| 2005-06-30 | vs CLE | 78 | L 3-9 | 43-35 | 2 | 27,272 | Hayden Penn | Jake Westbrook | Jake Westbrook | Hayden Penn | | 393 | 362 | 31 |
| 2005-07-01 | vs CLE | 79 | L 1-3 | 43-36 | 2 | 26,407 | Rodrigo Lopez | CC Sabathia | CC Sabathia | Rodrigo Lopez | Bob Wickman | 394 | 365 | 29 |
| 2005-07-02 | vs CLE | 80 | W 4-0 | 44-36 | 2 | 38,059 | Daniel Cabrera | Kevin Millwood | Daniel Cabrera | Kevin Millwood | | 398 | 365 | 33 |
| 2005-07-03 | vs CLE | 81 | L 4-9 | 44-37 | 2 | 41,655 | Sidney Ponson | Cliff Lee | Cliff Lee | Sidney Ponson | | 402 | 374 | 28 |
| 2005-07-04 | @ NYA | 82 | L 8-13 | 44-38 | 2 | 53,844 | Bruce Chen | Tanyon Sturtze | Jason Anderson | B.J. Ryan | | 410 | 387 | 23 |
| 2005-07-05 | @ NYA | 83 | L 3-12 | 44-39 | 2 | 55,276 | Rodrigo Lopez | Randy Johnson | Randy Johnson | Rodrigo Lopez | | 413 | 399 | 14 |
| 2005-07-07 | vs BOS | 84 | W 3-1 | 45-39 | 2 | 47,389 | Daniel Cabrera | David Wells | Daniel Cabrera | David Wells | Tim Byrdak | 416 | 400 | 16 |
| 2005-07-08 | vs BOS | 85 | L 2-7 | 45-40 | 3 | 49,174 | Sidney Ponson | Bronson Arroyo | Bronson Arroyo | Sidney Ponson | | 418 | 407 | 11 |
| 2005-07-09 | vs BOS | 86 | W 9-1 | 46-40 | 2 | 49,331 | Bruce Chen | Wade Miller | Bruce Chen | Wade Miller | | 427 | 408 | 19 |
| 2005-07-10 | vs BOS | 87 | W 4-1 | 47-40 | 2 | 49,828 | Rodrigo Lopez | Tim Wakefield | Rodrigo Lopez | Tim Wakefield | B.J. Ryan | 431 | 409 | 22 |
| 2005-07-14 | @ SEA | 88 | W 5-3 | 48-40 | 2 | 36,316 | Daniel Cabrera | Aaron Sele | Daniel Cabrera | Aaron Sele | B.J. Ryan | 436 | 412 | 24 |
| 2005-07-15 | @ SEA | 89 | W 6-3 | 49-40 | 2 | 39,044 | Rodrigo Lopez | Joel Pineiro | Rodrigo Lopez | Joel Pineiro | B.J. Ryan | 442 | 415 | 27 |
| 2005-07-16 | @ SEA | 90 | L 2-3 | 49-41 | 2 | 39,282 | Bruce Chen | Jamie Moyer | J.J. Putz | Chris Ray | | 444 | 418 | 26 |
| 2005-07-17 | @ SEA | 91 | L 2-8 | 49-42 | 3 | 41,215 | Sidney Ponson | Gil Meche | Gil Meche | Sidney Ponson | | 446 | 426 | 20 |
| 2005-07-18 | @ MIN | 92 | W 3-2 | 50-42 | 2 | 20,308 | Erik Bedard | Carlos Silva | Jorge Julio | Juan Rincon | | 449 | 428 | 21 |
| 2005-07-19 | @ MIN | 93 | L 3-4 | 50-43 | 3 | 26,183 | Daniel Cabrera | Kyle Lohse | Jesse Crain | B.J. Ryan | | 452 | 432 | 20 |
| 2005-07-20 | @ MIN | 94 | L 2-3 | 50-44 | 3 | 30,091 | Rodrigo Lopez | Brad Radke | Joe Nathan | Jason Grimsley | | 454 | 435 | 19 |
| 2005-07-22 | @ TBA | 95 | L 5-7 | 50-45 | 3 | 14,747 | Bruce Chen | Seth McClung | Seth McClung | Bruce Chen | Danys Baez | 459 | 442 | 17 |
| 2005-07-23 | @ TBA | 96 | L 2-3 | 50-46 | 3 | 20,571 | Sidney Ponson | Scott Kazmir | Scott Kazmir | Sidney Ponson | Danys Baez | 461 | 445 | 16 |
| 2005-07-24 | @ TBA | 97 | L 2-6 | 50-47 | 3 | 20,129 | Erik Bedard | Casey Fossum | Casey Fossum | Erik Bedard | | 463 | 451 | 12 |
| 2005-07-25 | vs TEX | 98 | L 2-4 | 50-48 | 3 | 29,314 | Daniel Cabrera | Joaquin Benoit | Joaquin Benoit | Daniel Cabrera | Francisco Cordero | 465 | 455 | 10 |
| 2005-07-26 | vs TEX | 99 | W 5-4 | 51-48 | 3 | 25,235 | Rodrigo Lopez | Kenny Rogers | Jason Grimsley | James Baldwin | B.J. Ryan | 470 | 459 | 11 |
| 2005-07-27 | vs TEX | 100 | L 8-11 | 51-49 | 3 | 31,540 | Bruce Chen | Chris Young | Francisco Cordero | Jorge Julio | James Baldwin | 478 | 470 | 8 |
| 2005-07-28 | vs TEX | 101 | L 1-2 | 51-50 | 4 | 22,254 | Sidney Ponson | Ricardo Rodriguez | Kameron Loe | Chris Ray | Francisco Cordero | 479 | 472 | 7 |
| 2005-07-29 | vs CHA | 102 | L 2-7 | 51-51 | 4 | 45,267 | Erik Bedard | Orlando Hernandez | Orlando Hernandez | Erik Bedard | | 481 | 479 | 2 |
| 2005-07-30 | vs CHA | 103 | L 6-9 | 51-52 | 4 | 40,100 | Daniel Cabrera | Jose Contreras | Neal Cotts | Chris Ray | Dustin Hermanson | 487 | 488 | -1 |
| 2005-07-31 | vs CHA | 104 | L 4-9 | 51-53 | 4 | 31,982 | Rodrigo Lopez | Freddy Garcia | Freddy Garcia | Rodrigo Lopez | | 491 | 497 | -6 |
| 2005-08-01 | vs CHA | 105 | L 3-6 | 51-54 | 4 | 47,823 | Daniel Cabrera | Mark Buehrle | Mark Buehrle | Daniel Cabrera | Dustin Hermanson | 494 | 503 | -9 |
| 2005-08-02 | @ ANA | 106 | L 1-10 | 51-55 | 4 | 43,643 | Sidney Ponson | Bartolo Colon | Bartolo Colon | Sidney Ponson | | 495 | 513 | -18 |
| 2005-08-03 | @ ANA | 107 | L 4-8 | 51-56 | 4 | 43,749 | Erik Bedard | John Lackey | John Lackey | Erik Bedard | | 499 | 521 | -22 |
| 2005-08-04 | @ ANA | 108 | W 4-1 | 52-56 | 4 | 43,877 | Rodrigo Lopez | Ervin Santana | Rodrigo Lopez | Ervin Santana | B.J. Ryan | 503 | 522 | -19 |
| 2005-08-05 | @ TEX | 109 | W 10-5 | 53-56 | 4 | 37,296 | Bruce Chen | C.J. Wilson | Bruce Chen | C.J. Wilson | | 513 | 527 | -14 |
| 2005-08-06 | @ TEX | 110 | L 3-10 | 53-57 | 4 | 34,632 | Daniel Cabrera | John Wasdin | John Wasdin | Daniel Cabrera | Kameron Loe | 516 | 537 | -21 |
| 2005-08-07 | @ TEX | 111 | L 3-9 | 53-58 | 4 | 27,137 | Sidney Ponson | Chris Young | Chris Young | Sidney Ponson | | 519 | 546 | -27 |
| 2005-08-09 | vs TBA | 112 | W 5-2 | 54-58 | 4 | 34,870 | Erik Bedard | Scott Kazmir | Erik Bedard | Scott Kazmir | B.J. Ryan | 524 | 548 | -24 |
| 2005-08-10 | vs TBA | 113 | W 9-5 | 55-58 | 4 | 25,556 | Rodrigo Lopez | Casey Fossum | Rodrigo Lopez | Casey Fossum | | 533 | 553 | -20 |
| 2005-08-11 | vs TBA | 114 | W 4-2 | 56-58 | 4 | 27,958 | Bruce Chen | Doug Waechter | Bruce Chen | Doug Waechter | B.J. Ryan | 537 | 555 | -18 |
| 2005-08-12 | vs TOR | 115 | L 0-12 | 56-59 | 4 | 29,069 | Daniel Cabrera | Josh Towers | Josh Towers | Daniel Cabrera | | 537 | 567 | -30 |
| 2005-08-13 | vs TOR | 116 | W 1-0 | 57-59 | 4 | 29,445 | John Maine | David Bush | John Maine | David Bush | B.J. Ryan | 538 | 567 | -29 |
| 2005-08-14 | vs TOR | 117 | L 6-7 | 57-60 | 4 | 30,954 | Erik Bedard | Dustin McGowan | Jason Frasor | Tim Byrdak | Miguel Batista | 544 | 574 | -30 |
| 2005-08-15 | @ OAK | 118 | W 6-2 | 58-60 | 4 | 20,285 | Rodrigo Lopez | Barry Zito | Rodrigo Lopez | Barry Zito | | 550 | 576 | -26 |
| 2005-08-16 | @ OAK | 119 | W 4-3 | 59-60 | 4 | 23,252 | Bruce Chen | Joe Blanton | Bruce Chen | Jay Witasick | B.J. Ryan | 554 | 579 | -25 |
| 2005-08-17 | @ OAK | 120 | W 5-3 | 60-60 | 4 | 32,290 | Eric DuBose | Dan Haren | Eric DuBose | Dan Haren | Todd Williams | 559 | 582 | -23 |
| 2005-08-19 | @ CLE | 121 | L 4-5 | 60-61 | 4 | 33,160 | Erik Bedard | Scott Elarton | Fernando Cabrera | Steve Kline | | 563 | 587 | -24 |
| 2005-08-20 | @ CLE | 122 | L 1-6 | 60-62 | 4 | 41,034 | Rodrigo Lopez | Cliff Lee | Cliff Lee | Rodrigo Lopez | | 564 | 593 | -29 |
| 2005-08-21 | @ CLE | 123 | L 1-5 | 60-63 | 4 | 28,025 | Bruce Chen | CC Sabathia | CC Sabathia | Bruce Chen | | 565 | 598 | -33 |
| 2005-08-23 | vs ANA | 124 | L 6-7 | 60-64 | 4 | 31,768 | Eric DuBose | Jarrod Washburn | Jarrod Washburn | Eric DuBose | Francisco Rodriguez | 571 | 605 | -34 |
| 2005-08-24 | vs ANA | 125 | L 1-3 | 60-65 | 4 | 27,586 | Erik Bedard | Bartolo Colon | Bartolo Colon | Erik Bedard | Francisco Rodriguez | 572 | 608 | -36 |
| 2005-08-25 | vs ANA | 126 | W 2-0 | 61-65 | 4 | 26,832 | Rodrigo Lopez | John Lackey | Rodrigo Lopez | John Lackey | B.J. Ryan | 574 | 608 | -34 |
| 2005-08-26 | vs OAK | 127 | L 1-4 | 61-66 | 4 | 26,105 | Bruce Chen | Joe Blanton | Joe Blanton | Bruce Chen | Huston Street | 575 | 612 | -37 |
| 2005-08-27 | vs OAK | 128 | L 3-12 | 61-67 | 4 | 33,195 | Eric DuBose | Joe Kennedy | Joe Kennedy | Eric DuBose | | 578 | 624 | -46 |
| 2005-08-28 | vs OAK | 129 | L 3-10 | 61-68 | 4 | 26,971 | John Maine | Dan Haren | Dan Haren | John Maine | | 581 | 634 | -53 |
| 2005-08-29 | vs OAK | 130 | L 5-10 | 61-69 | 4 | 18,287 | Erik Bedard | Kirk Saarloos | Kiko Calero | Jorge Julio | | 586 | 644 | -58 |
| 2005-08-30 | @ TOR | 131 | L 2-7 | 61-70 | 4 | 25,311 | Rodrigo Lopez | David Bush | David Bush | Rodrigo Lopez | | 588 | 651 | -63 |
| 2005-08-31 | @ TOR | 132 | W 7-0 | 62-70 | 4 | 24,686 | Bruce Chen | Gustavo Chacin | Bruce Chen | Gustavo Chacin | | 595 | 651 | -56 |
| 2005-09-01 | @ TOR | 133 | W 5-3 | 63-70 | 4 | 20,928 | Hayden Penn | Dustin McGowan | Hayden Penn | Dustin McGowan | B.J. Ryan | 600 | 654 | -54 |
| 2005-09-02 | @ BOS | 134 | W 7-3 | 64-70 | 4 | 35,156 | John Maine | Lenny DiNardo | John Maine | Lenny DiNardo | | 607 | 657 | -50 |
| 2005-09-03 | @ BOS | 135 | L 6-7 | 64-71 | 4 | 35,142 | Erik Bedard | Matt Clement | Matt Clement | Erik Bedard | Mike Timlin | 613 | 664 | -51 |
| 2005-09-04 | @ BOS | 136 | L 1-5 | 64-72 | 4 | 35,003 | Rodrigo Lopez | David Wells | David Wells | Rodrigo Lopez | | 614 | 669 | -55 |
| 2005-09-05 | vs TOR | 137 | L 2-6 | 64-73 | 4 | 22,123 | Bruce Chen | Gustavo Chacin | Gustavo Chacin | Bruce Chen | | 616 | 675 | -59 |
| 2005-09-06 | vs TOR | 138 | W 5-0 | 65-73 | 4 | 20,729 | Daniel Cabrera | Ted Lilly | Daniel Cabrera | Ted Lilly | | 621 | 675 | -54 |
| 2005-09-07 | vs TOR | 139 | L 4-7 | 65-74 | 4 | 20,146 | John Maine | Scott Downs | Pete Walker | Jorge Julio | Miguel Batista | 625 | 682 | -57 |
| 2005-09-09 | @ SEA | 140 | L 2-3 | 65-75 | 4 | 27,429 | Erik Bedard | Jamie Moyer | Jamie Moyer | Erik Bedard | J.J. Putz | 627 | 685 | -58 |
| 2005-09-10 | @ SEA | 141 | W 5-3 | 66-75 | 4 | 30,408 | Rodrigo Lopez | Jeff Harris | Rodrigo Lopez | Jeff Harris | B.J. Ryan | 632 | 688 | -56 |
| 2005-09-11 | @ SEA | 142 | W 6-3 | 67-75 | 4 | 30,212 | Bruce Chen | Felix Hernandez | Bruce Chen | Felix Hernandez | B.J. Ryan | 638 | 691 | -53 |
| 2005-09-12 | @ TEX | 143 | W 4-2 | 68-75 | 4 | 20,418 | Daniel Cabrera | Edinson Volquez | Daniel Cabrera | Edinson Volquez | B.J. Ryan | 642 | 693 | -51 |
| 2005-09-13 | @ TEX | 144 | W 4-3 | 69-75 | 4 | 21,167 | John Maine | R.A. Dickey | Chris Ray | C.J. Wilson | B.J. Ryan | 646 | 696 | -50 |
| 2005-09-14 | @ TEX | 145 | L 6-7 | 69-76 | 4 | 18,077 | Erik Bedard | Juan Dominguez | Joaquin Benoit | Jason Grimsley | | 652 | 703 | -51 |
| 2005-09-16 | vs TBA | 146 | L 1-6 | 69-77 | 4 | 19,972 | Rodrigo Lopez | Scott Kazmir | Scott Kazmir | Rodrigo Lopez | Danys Baez | 653 | 709 | -56 |
| 2005-09-17 | vs TBA | 147 | W 2-1 | 70-77 | 4 | 31,400 | Bruce Chen | Casey Fossum | Todd Williams | Joe Borowski | B.J. Ryan | 655 | 710 | -55 |
| 2005-09-18 | vs TBA | 148 | L 5-6 | 70-78 | 4 | 25,980 | Daniel Cabrera | Doug Waechter | Travis Harper | Todd Williams | Danys Baez | 660 | 716 | -56 |
| 2005-09-19 | @ NYA | 149 | L 2-3 | 70-79 | 4 | 51,521 | Erik Bedard | Chien-Ming Wang | Mariano Rivera | Eric DuBose | | 662 | 719 | -57 |
| 2005-09-20 | @ NYA | 150 | L 9-12 | 70-80 | 4 | 46,982 | John Maine | Aaron Small | Aaron Small | John Maine | | 671 | 731 | -60 |
| 2005-09-21 | @ NYA | 151 | L 1-2 | 70-81 | 4 | 50,382 | Rodrigo Lopez | Randy Johnson | Randy Johnson | Rodrigo Lopez | Mariano Rivera | 672 | 733 | -61 |
| 2005-09-22 | @ NYA | 152 | L 6-7 | 70-82 | 4 | 52,368 | Bruce Chen | Mike Mussina | Mike Mussina | Bruce Chen | Tom Gordon | 678 | 740 | -62 |
| 2005-09-23 | vs BOS | 153 | L 3-6 | 70-83 | 4 | 46,850 | Daniel Cabrera | Bronson Arroyo | Bronson Arroyo | Daniel Cabrera | Mike Timlin | 681 | 746 | -65 |
| 2005-09-24 | vs BOS | 154 | L 3-4 | 70-84 | 4 | 48,612 | Erik Bedard | Matt Clement | Jonathan Papelbon | B.J. Ryan | Mike Timlin | 684 | 750 | -66 |
| 2005-09-25 | vs BOS | 155 | L 3-9 | 70-85 | 4 | 46,559 | John Maine | David Wells | David Wells | John Maine | | 687 | 759 | -72 |
| 2005-09-26 | vs NYA | 156 | L 3-11 | 70-86 | 4 | 43,039 | Rodrigo Lopez | Randy Johnson | Randy Johnson | Rodrigo Lopez | | 690 | 770 | -80 |
| 2005-09-27 | vs NYA | 157 | W 17-9 | 71-86 | 4 | 29,557 | Bruce Chen | Mike Mussina | Aaron Rakers | Al Leiter | | 707 | 779 | -72 |
| 2005-09-28 | vs NYA | 158 | L 1-2 | 71-87 | 4 | 30,539 | Daniel Cabrera | Shawn Chacon | Shawn Chacon | Daniel Cabrera | Mariano Rivera | 708 | 781 | -73 |
| 2005-09-29 | vs NYA | 159 | L 4-8 | 71-88 | 4 | 36,821 | Erik Bedard | Aaron Small | Aaron Small | Erik Bedard | | 712 | 789 | -77 |
| 2005-09-30 | @ TBA | 160 | W 7-6 | 72-88 | 4 | 15,805 | John Maine | Doug Waechter | Eric DuBose | Doug Waechter | B.J. Ryan | 719 | 795 | -76 |
| 2005-10-01 | @ TBA | 161 | W 4-3 | 73-88 | 4 | 17,481 | Rodrigo Lopez | Mark Hendrickson | Rodrigo Lopez | Mark Hendrickson | B.J. Ryan | 723 | 798 | -75 |
| 2005-10-02 | @ TBA | 162 | W 6-2 | 74-88 | 4 | 17,450 | Bruce Chen | Tim Corcoran | Bruce Chen | Jesus Colome | | 729 | 800 | -71 |