| 2005-04-04 | @ PHI | 1 | L 4-8 | 0-1 | 5 | 44,080 | Livan Hernandez | Jon Lieber | Jon Lieber | Livan Hernandez | | 4 | 8 | -4 |
| 2005-04-06 | @ PHI | 2 | W 7-3 | 1-1 | 4 | 23,435 | Zach Day | Brett Myers | Joey Eischen | Tim Worrell | | 11 | 11 | 0 |
| 2005-04-07 | @ PHI | 3 | W 5-4 | 2-1 | 2 | 21,693 | Esteban Loaiza | Randy Wolf | Chad Cordero | Rheal Cormier | | 16 | 15 | 1 |
| 2005-04-08 | @ FLO | 4 | L 0-9 | 2-2 | 3 | 19,327 | Tomo Ohka | Dontrelle Willis | Dontrelle Willis | Tomo Ohka | | 16 | 24 | -8 |
| 2005-04-09 | @ FLO | 5 | W 3-2 | 3-2 | 2 | 30,739 | Livan Hernandez | Brian Moehler | Chad Cordero | Antonio Alfonseca | | 19 | 26 | -7 |
| 2005-04-10 | @ FLO | 6 | L 0-8 | 3-3 | 4 | 25,089 | John Patterson | Josh Beckett | Josh Beckett | John Patterson | | 19 | 34 | -15 |
| 2005-04-11 | @ ATL | 7 | L 2-11 | 3-4 | 4 | 16,584 | Zach Day | Mike Hampton | Mike Hampton | Zach Day | | 21 | 45 | -24 |
| 2005-04-12 | @ ATL | 8 | W 4-3 | 4-4 | 4 | 20,122 | Esteban Loaiza | Tim Hudson | Luis Ayala | Danny Kolb | Chad Cordero | 25 | 48 | -23 |
| 2005-04-13 | @ ATL | 9 | W 11-4 | 5-4 | 3 | 19,093 | Tomo Ohka | John Thomson | Tomo Ohka | John Thomson | | 36 | 52 | -16 |
| 2005-04-14 | vs ARI | 10 | W 5-3 | 6-4 | 1 | 45,596 | Livan Hernandez | Javier Vazquez | Livan Hernandez | Javier Vazquez | Chad Cordero | 41 | 55 | -14 |
| 2005-04-16 | vs ARI | 11 | W 9-3 | 7-4 | 1 | 34,943 | John Patterson | Russ Ortiz | John Patterson | Russ Ortiz | | 50 | 58 | -8 |
| 2005-04-17 | vs ARI | 12 | W 7-3 | 8-4 | 1 | 35,463 | Esteban Loaiza | Brad Halsey | T.J. Tucker | Mike Koplove | | 57 | 61 | -4 |
| 2005-04-18 | vs FLO | 13 | L 4-9 | 8-5 | 1 | 24,003 | Tomo Ohka | Dontrelle Willis | Dontrelle Willis | Tomo Ohka | | 61 | 70 | -9 |
| 2005-04-19 | vs FLO | 14 | L 3-6 | 8-6 | 2 | 25,990 | Livan Hernandez | Brian Moehler | Brian Moehler | Livan Hernandez | | 64 | 76 | -12 |
| 2005-04-20 | vs ATL | 15 | W 2-0 | 9-6 | 2 | 27,374 | Zach Day | Horacio Ramirez | Zach Day | Horacio Ramirez | Chad Cordero | 66 | 76 | -10 |
| 2005-04-21 | vs ATL | 16 | L 1-2 | 9-7 | 2 | 30,728 | John Patterson | John Smoltz | Chris Reitsma | Chad Cordero | Danny Kolb | 67 | 78 | -11 |
| 2005-04-22 | @ NYN | 17 | L 1-3 | 9-8 | 4 | 28,488 | Esteban Loaiza | Tom Glavine | Tom Glavine | Esteban Loaiza | Braden Looper | 68 | 81 | -13 |
| 2005-04-23 | @ NYN | 18 | L 5-10 | 9-9 | 4 | 44,058 | Tomo Ohka | Jae Weong Seo | Jae Weong Seo | Tomo Ohka | | 73 | 91 | -18 |
| 2005-04-24 | @ NYN | 19 | W 11-4 | 10-9 | 4 | 43,313 | Livan Hernandez | Victor Zambrano | Livan Hernandez | Victor Zambrano | | 84 | 95 | -11 |
| 2005-04-25 | vs PHI | 20 | L 4-5 | 10-10 | 4 | 24,956 | Zach Day | Cory Lidle | Cory Lidle | Zach Day | Billy Wagner | 88 | 100 | -12 |
| 2005-04-26 | vs PHI | 21 | W 3-1 | 11-10 | 4 | 23,332 | John Patterson | Jon Lieber | John Patterson | Jon Lieber | Chad Cordero | 91 | 101 | -10 |
| 2005-04-27 | vs PHI | 22 | L 0-3 | 11-11 | 4 | 27,483 | Esteban Loaiza | Brett Myers | Rheal Cormier | Esteban Loaiza | Billy Wagner | 91 | 104 | -13 |
| 2005-04-29 | vs NYN | 23 | W 5-1 | 12-11 | 3 | 30,627 | Livan Hernandez | Jae Weong Seo | Livan Hernandez | Jae Weong Seo | Chad Cordero | 96 | 105 | -9 |
| 2005-04-30 | vs NYN | 24 | W 5-3 | 13-11 | 3 | 40,913 | Tomo Ohka | Victor Zambrano | Tomo Ohka | Victor Zambrano | Hector Carrasco | 101 | 108 | -7 |
| 2005-05-01 | vs NYN | 25 | L 3-6 | 13-12 | 3 | 27,333 | John Patterson | Aaron Heilman | Roberto Hernandez | Luis Ayala | Braden Looper | 104 | 114 | -10 |
| 2005-05-02 | @ LAN | 26 | W 6-2 | 14-12 | 3 | 34,079 | Esteban Loaiza | Scott Erickson | Esteban Loaiza | Scott Erickson | | 110 | 116 | -6 |
| 2005-05-03 | @ LAN | 27 | L 2-4 | 14-13 | 3 | 41,190 | Zach Day | Jeff Weaver | Jeff Weaver | Jon Rauch | Yhency Brazoban | 112 | 120 | -8 |
| 2005-05-04 | @ LAN | 28 | W 5-2 | 15-13 | 3 | 33,081 | Livan Hernandez | Odalis Perez | Livan Hernandez | Odalis Perez | | 117 | 122 | -5 |
| 2005-05-06 | @ SFN | 29 | W 9-3 | 16-13 | 3 | 40,425 | Tomo Ohka | Noah Lowry | Jon Rauch | Noah Lowry | | 126 | 125 | 1 |
| 2005-05-07 | @ SFN | 30 | W 11-8 | 17-13 | 3 | 40,220 | John Patterson | Jason Schmidt | Luis Ayala | Jeremy Accardo | Chad Cordero | 137 | 133 | 4 |
| 2005-05-08 | @ SFN | 31 | L 3-4 | 17-14 | 3 | 36,903 | Esteban Loaiza | Kirk Rueter | Jason Christiansen | Jon Rauch | | 140 | 137 | 3 |
| 2005-05-09 | @ ARI | 32 | W 4-3 | 18-14 | 3 | 19,440 | Livan Hernandez | Brandon Webb | Livan Hernandez | Jose Valverde | Chad Cordero | 144 | 140 | 4 |
| 2005-05-10 | @ ARI | 33 | L 2-3 | 18-15 | 3 | 23,181 | Tony Armas | Shawn Estes | Shawn Estes | Tony Armas | Brandon Lyon | 146 | 143 | 3 |
| 2005-05-11 | @ ARI | 34 | L 2-3 | 18-16 | 3 | 21,011 | Claudio Vargas | Javier Vazquez | Lance Cormier | Jon Rauch | Brandon Lyon | 148 | 146 | 2 |
| 2005-05-13 | vs CHN | 35 | L 3-6 | 18-17 | 4 | 36,585 | Esteban Loaiza | Glendon Rusch | Will Ohman | Luis Ayala | Todd Wellemeyer | 151 | 152 | -1 |
| 2005-05-14 | vs CHN | 36 | W 4-3 | 19-17 | 3 | 42,829 | Livan Hernandez | Carlos Zambrano | Livan Hernandez | Carlos Zambrano | Chad Cordero | 155 | 155 | 0 |
| 2005-05-15 | vs CHN | 37 | W 5-4 | 20-17 | 3 | 44,103 | John Patterson | Greg Maddux | Hector Carrasco | Cliff Bartosh | Chad Cordero | 160 | 159 | 1 |
| 2005-05-16 | vs MIL | 38 | W 5-2 | 21-17 | 3 | 26,606 | Tony Armas | Doug Davis | Tony Armas | Doug Davis | Luis Ayala | 165 | 161 | 4 |
| 2005-05-17 | vs MIL | 39 | L 2-8 | 21-18 | 3 | 26,427 | Claudio Vargas | Wes Obermueller | Wes Obermueller | Claudio Vargas | | 167 | 169 | -2 |
| 2005-05-18 | vs MIL | 40 | W 1-0 | 22-18 | 3 | 29,216 | Esteban Loaiza | Chris Capuano | Gary Majewski | Chris Capuano | | 168 | 169 | -1 |
| 2005-05-19 | vs MIL | 41 | W 3-2 | 23-18 | 3 | 30,968 | Livan Hernandez | Victor Santos | Livan Hernandez | Victor Santos | Chad Cordero | 171 | 171 | 0 |
| 2005-05-20 | @ TOR | 42 | L 1-6 | 23-19 | 3 | 17,465 | Claudio Vargas | Ted Lilly | Ted Lilly | Claudio Vargas | Pete Walker | 172 | 177 | -5 |
| 2005-05-21 | @ TOR | 43 | L 0-7 | 23-20 | 4 | 24,518 | Tony Armas | Roy Halladay | Roy Halladay | Tony Armas | | 172 | 184 | -12 |
| 2005-05-22 | @ TOR | 44 | W 9-2 | 24-20 | 3 | 28,408 | Tomo Ohka | Josh Towers | Tomo Ohka | Josh Towers | | 181 | 186 | -5 |
| 2005-05-23 | @ CIN | 45 | L 3-5 | 24-21 | 3 | 17,630 | Esteban Loaiza | Eric Milton | Eric Milton | Esteban Loaiza | David Weathers | 184 | 191 | -7 |
| 2005-05-24 | @ CIN | 46 | L 3-4 | 24-22 | 3 | 36,539 | Livan Hernandez | Brandon Claussen | Randy Keisler | Luis Ayala | | 187 | 195 | -8 |
| 2005-05-25 | @ CIN | 47 | L 3-12 | 24-23 | 3 | 20,497 | Claudio Vargas | Matt Belisle | Matt Belisle | Claudio Vargas | | 190 | 207 | -17 |
| 2005-05-27 | @ SLN | 48 | L 3-6 | 24-24 | 4 | 47,383 | Tony Armas | Matt Morris | Matt Morris | Tony Armas | Jason Isringhausen | 193 | 213 | -20 |
| 2005-05-28 | @ SLN | 49 | L 1-3 | 24-25 | 4 | 49,123 | Esteban Loaiza | Jeff Suppan | Jeff Suppan | Esteban Loaiza | Jason Isringhausen | 194 | 216 | -22 |
| 2005-05-29 | @ SLN | 50 | W 3-2 | 25-25 | 4 | 47,012 | Livan Hernandez | Chris Carpenter | Livan Hernandez | Chris Carpenter | Chad Cordero | 197 | 218 | -21 |
| 2005-05-30 | vs ATL | 51 | W 3-2 | 26-25 | 4 | 39,705 | Tomo Ohka | Kyle Davies | Tomo Ohka | Kyle Davies | Chad Cordero | 200 | 220 | -20 |
| 2005-05-31 | vs ATL | 52 | W 5-4 | 27-25 | 3 | 29,512 | John Patterson | Mike Hampton | Luis Ayala | Roman Colon | Chad Cordero | 205 | 224 | -19 |
| 2005-06-01 | vs ATL | 53 | L 4-5 | 27-26 | 4 | 28,280 | Tony Armas | John Smoltz | John Smoltz | Hector Carrasco | Chris Reitsma | 209 | 229 | -20 |
| 2005-06-02 | vs ATL | 54 | W 8-6 | 28-26 | 4 | 29,225 | Esteban Loaiza | Horacio Ramirez | Hector Carrasco | Danny Kolb | Chad Cordero | 217 | 235 | -18 |
| 2005-06-03 | vs FLO | 55 | W 3-2 | 29-26 | 3 | 29,439 | Livan Hernandez | Josh Beckett | Luis Ayala | Nate Bump | | 220 | 237 | -17 |
| 2005-06-04 | vs FLO | 56 | W 7-3 | 30-26 | 2 | 33,198 | Tomo Ohka | Al Leiter | Sun-Woo Kim | Al Leiter | | 227 | 240 | -13 |
| 2005-06-05 | vs FLO | 57 | W 6-3 | 31-26 | 1 | 40,995 | John Patterson | A.J. Burnett | Luis Ayala | John Riedling | Chad Cordero | 233 | 243 | -10 |
| 2005-06-07 | vs OAK | 58 | W 2-1 | 32-26 | 1 | 26,879 | Tony Armas | Barry Zito | Tony Armas | Barry Zito | Chad Cordero | 235 | 244 | -9 |
| 2005-06-08 | vs OAK | 59 | W 7-2 | 33-26 | 1 | 28,749 | Esteban Loaiza | Ryan Glynn | Esteban Loaiza | Ryan Glynn | | 242 | 246 | -4 |
| 2005-06-09 | vs OAK | 60 | W 4-3 | 34-26 | 1 | 26,672 | Livan Hernandez | Joe Blanton | Livan Hernandez | Joe Blanton | Chad Cordero | 246 | 249 | -3 |
| 2005-06-10 | vs SEA | 61 | W 9-3 | 35-26 | 1 | 28,707 | Sun-Woo Kim | Joel Pineiro | Luis Ayala | Shigetoshi Hasegawa | | 255 | 252 | 3 |
| 2005-06-11 | vs SEA | 62 | W 2-1 | 36-26 | 1 | 39,108 | John Patterson | Jamie Moyer | John Patterson | J.J. Putz | Chad Cordero | 257 | 253 | 4 |
| 2005-06-12 | vs SEA | 63 | W 3-2 | 37-26 | 1 | 37,170 | Tony Armas | Ryan Franklin | Tony Armas | Ryan Franklin | Chad Cordero | 260 | 255 | 5 |
| 2005-06-13 | @ ANA | 64 | L 1-11 | 37-27 | 1 | 40,790 | Esteban Loaiza | Paul Byrd | Paul Byrd | Esteban Loaiza | | 261 | 266 | -5 |
| 2005-06-14 | @ ANA | 65 | W 6-3 | 38-27 | 1 | 43,874 | Livan Hernandez | Ervin Santana | Gary Majewski | Scot Shields | Chad Cordero | 267 | 269 | -2 |
| 2005-06-15 | @ ANA | 66 | W 1-0 | 39-27 | 1 | 43,505 | Ryan Drese | Bartolo Colon | Ryan Drese | Bartolo Colon | Chad Cordero | 268 | 269 | -1 |
| 2005-06-17 | @ TEX | 67 | L 1-8 | 39-28 | 1 | 33,653 | John Patterson | Kenny Rogers | Kenny Rogers | John Patterson | | 269 | 277 | -8 |
| 2005-06-18 | @ TEX | 68 | L 4-7 | 39-29 | 1 | 48,663 | Tony Armas | Ricardo Rodriguez | Ricardo Rodriguez | Tony Armas | | 273 | 284 | -11 |
| 2005-06-19 | @ TEX | 69 | W 8-2 | 40-29 | 1 | 34,474 | Sun-Woo Kim | C.J. Wilson | Travis Hughes | C.J. Wilson | | 281 | 286 | -5 |
| 2005-06-20 | @ PIT | 70 | W 7-4 | 41-29 | 1 | 21,893 | Livan Hernandez | Mark Redman | Livan Hernandez | Mark Redman | Chad Cordero | 288 | 290 | -2 |
| 2005-06-21 | @ PIT | 71 | L 4-11 | 41-30 | 1 | 26,006 | Ryan Drese | Oliver Perez | Oliver Perez | Ryan Drese | | 292 | 301 | -9 |
| 2005-06-22 | @ PIT | 72 | W 5-4 | 42-30 | 1 | 24,064 | John Patterson | Josh Fogg | Hector Carrasco | Mike Gonzalez | Chad Cordero | 297 | 305 | -8 |
| 2005-06-24 | vs TOR | 73 | W 3-0 | 43-30 | 1 | 36,689 | Esteban Loaiza | Josh Towers | Esteban Loaiza | Josh Towers | Chad Cordero | 300 | 305 | -5 |
| 2005-06-25 | vs TOR | 74 | W 5-2 | 44-30 | 1 | 39,881 | Livan Hernandez | Ted Lilly | Livan Hernandez | Ted Lilly | Chad Cordero | 305 | 307 | -2 |
| 2005-06-26 | vs TOR | 75 | L 5-9 | 44-31 | 1 | 33,557 | Tony Armas | Gustavo Chacin | Justin Speier | Luis Ayala | Miguel Batista | 310 | 316 | -6 |
| 2005-06-28 | vs PIT | 76 | W 2-1 | 45-31 | 1 | 35,828 | Ryan Drese | Josh Fogg | Ryan Drese | Josh Fogg | Chad Cordero | 312 | 317 | -5 |
| 2005-06-29 | vs PIT | 77 | W 3-2 | 46-31 | 1 | 31,213 | John Patterson | David Williams | Luis Ayala | Salomon Torres | Chad Cordero | 315 | 319 | -4 |
| 2005-06-30 | vs PIT | 78 | W 7-5 | 47-31 | 1 | 37,361 | Esteban Loaiza | Kip Wells | Esteban Loaiza | Kip Wells | Chad Cordero | 322 | 324 | -2 |
| 2005-07-01 | @ CHN | 79 | W 4-3 | 48-31 | 1 | 38,973 | Livan Hernandez | Mark Prior | Livan Hernandez | Mark Prior | Hector Carrasco | 326 | 327 | -1 |
| 2005-07-02 | @ CHN | 80 | W 4-2 | 49-31 | 1 | 40,488 | Tony Armas | Jerome Williams | Tony Armas | Jerome Williams | Chad Cordero | 330 | 329 | 1 |
| 2005-07-03 | @ CHN | 81 | W 5-4 | 50-31 | 1 | 40,006 | Ryan Drese | Carlos Zambrano | Joey Eischen | Sergio Mitre | | 335 | 333 | 2 |
| 2005-07-04 | vs NYN | 82 | L 2-5 | 50-32 | 1 | 44,331 | John Patterson | Kazuhisa Ishii | Roberto Hernandez | Sun-Woo Kim | Braden Looper | 337 | 338 | -1 |
| 2005-07-05 | vs NYN | 83 | W 3-2 | 51-32 | 1 | 35,087 | Esteban Loaiza | Pedro Martinez | Esteban Loaiza | Pedro Martinez | Chad Cordero | 340 | 340 | 0 |
| 2005-07-06 | vs NYN | 84 | L 3-5 | 51-33 | 1 | 38,148 | Livan Hernandez | Tom Glavine | Tom Glavine | Livan Hernandez | Braden Looper | 343 | 345 | -2 |
| 2005-07-07 | vs NYN | 85 | L 2-3 | 51-34 | 1 | 44,492 | Tony Armas | Kris Benson | Heath Bell | Luis Ayala | Braden Looper | 345 | 348 | -3 |
| 2005-07-08 | @ PHI | 86 | W 8-7 | 52-34 | 1 | 44,688 | Ryan Drese | Rob Tejeda | Ryan Drese | Rob Tejeda | Chad Cordero | 353 | 355 | -2 |
| 2005-07-09 | @ PHI | 87 | L 0-1 | 52-35 | 1 | 33,365 | John Patterson | Cory Lidle | Billy Wagner | Hector Carrasco | | 353 | 356 | -3 |
| 2005-07-10 | @ PHI | 88 | L 4-5 | 52-36 | 1 | 34,124 | Esteban Loaiza | Jon Lieber | Rheal Cormier | Sun-Woo Kim | | 357 | 361 | -4 |
| 2005-07-14 | @ MIL | 89 | L 2-4 | 52-37 | 1 | 30,611 | John Patterson | Doug Davis | Matt Wise | Gary Majewski | Derrick Turnbow | 359 | 365 | -6 |
| 2005-07-15 | @ MIL | 90 | L 3-4 | 52-38 | 1 | 40,690 | Livan Hernandez | Ben Sheets | Julio Santana | Luis Ayala | | 362 | 369 | -7 |
| 2005-07-16 | @ MIL | 91 | W 5-3 | 53-38 | 1 | 45,079 | Esteban Loaiza | Chris Capuano | Esteban Loaiza | Ricky Bottalico | Chad Cordero | 367 | 372 | -5 |
| 2005-07-17 | @ MIL | 92 | L 3-5 | 53-39 | 1 | 23,543 | Ryan Drese | Tomo Ohka | Tomo Ohka | Ryan Drese | Derrick Turnbow | 370 | 377 | -7 |
| 2005-07-18 | vs COL | 93 | L 4-5 | 53-40 | 1 | 30,165 | Tony Armas | Byung-Hyun Kim | Jose Acevedo | Chad Cordero | Brian Fuentes | 374 | 382 | -8 |
| 2005-07-19 | vs COL | 94 | W 4-0 | 54-40 | 1 | 30,655 | John Patterson | Shawn Chacon | John Patterson | Shawn Chacon | Chad Cordero | 378 | 382 | -4 |
| 2005-07-20 | vs COL | 95 | L 2-3 | 54-41 | 1 | 32,381 | Livan Hernandez | Jason Jennings | Jason Jennings | Livan Hernandez | Brian Fuentes | 380 | 385 | -5 |
| 2005-07-21 | vs HOU | 96 | L 2-3 | 54-42 | 2 | 36,840 | Esteban Loaiza | Roy Oswalt | Roy Oswalt | Esteban Loaiza | Brad Lidge | 382 | 388 | -6 |
| 2005-07-22 | vs HOU | 97 | L 1-14 | 54-43 | 2 | 38,019 | Ryan Drese | Roger Clemens | Roger Clemens | Ryan Drese | | 383 | 402 | -19 |
| 2005-07-23 | vs HOU | 98 | W 4-2 | 55-43 | 2 | 42,680 | Tony Armas | Brandon Backe | Tony Armas | Brandon Backe | Chad Cordero | 387 | 404 | -17 |
| 2005-07-24 | vs HOU | 99 | L 1-4 | 55-44 | 2 | 39,203 | John Patterson | Wandy Rodriguez | Russ Springer | Hector Carrasco | Brad Lidge | 388 | 408 | -20 |
| 2005-07-26 | @ ATL | 100 | L 2-3 | 55-45 | 2 | 43,308 | Livan Hernandez | John Smoltz | Chris Reitsma | Mike Stanton | | 390 | 411 | -21 |
| 2005-07-27 | @ ATL | 101 | L 3-4 | 55-46 | 2 | 40,625 | Esteban Loaiza | Tim Hudson | Danny Kolb | Gary Majewski | Chris Reitsma | 393 | 415 | -22 |
| 2005-07-28 | @ ATL | 102 | L 4-5 | 55-47 | 2 | 40,269 | Ryan Drese | Jorge Sosa | Jorge Sosa | Ryan Drese | Chris Reitsma | 397 | 420 | -23 |
| 2005-07-29 | @ FLO | 103 | L 3-4 | 55-48 | 2 | 29,322 | Tony Armas | Josh Beckett | Josh Beckett | Tony Armas | Todd Jones | 400 | 424 | -24 |
| 2005-07-30 | @ FLO | 104 | L 0-3 | 55-49 | 2 | 25,308 | John Patterson | A.J. Burnett | A.J. Burnett | John Patterson | Todd Jones | 400 | 427 | -27 |
| 2005-07-31 | @ FLO | 105 | W 4-2 | 56-49 | 2 | 30,397 | Livan Hernandez | Brian Moehler | Livan Hernandez | Brian Moehler | Chad Cordero | 404 | 429 | -25 |
| 2005-08-02 | vs LAN | 106 | L 4-5 | 56-50 | 2 | 36,277 | Esteban Loaiza | Jeff Weaver | Jeff Weaver | Esteban Loaiza | Yhency Brazoban | 408 | 434 | -26 |
| 2005-08-03 | vs LAN | 107 | W 3-1 | 57-50 | 2 | 36,552 | Tony Armas | D.J. Houlton | Tony Armas | D.J. Houlton | Chad Cordero | 411 | 435 | -24 |
| 2005-08-04 | vs LAN | 108 | W 7-0 | 58-50 | 2 | 35,484 | John Patterson | Brad Penny | John Patterson | Brad Penny | | 418 | 435 | -17 |
| 2005-08-05 | vs SDN | 109 | L 5-6 | 58-51 | 2 | 34,492 | Livan Hernandez | Woody Williams | Scott Linebrink | Chad Cordero | Trevor Hoffman | 423 | 441 | -18 |
| 2005-08-06 | vs SDN | 110 | L 2-3 | 58-52 | 2 | 38,076 | Ryan Drese | Pedro Astacio | Pedro Astacio | Ryan Drese | Trevor Hoffman | 425 | 444 | -19 |
| 2005-08-07 | vs SDN | 111 | L 0-3 | 58-53 | 3 | 36,440 | Esteban Loaiza | Jake Peavy | Jake Peavy | Esteban Loaiza | | 425 | 447 | -22 |
| 2005-08-09 | @ HOU | 112 | W 6-5 | 59-53 | 2 | 34,255 | John Patterson | Ezequiel Astacio | John Patterson | Ezequiel Astacio | Chad Cordero | 431 | 452 | -21 |
| 2005-08-10 | @ HOU | 113 | L 6-7 | 59-54 | 4 | 34,309 | Livan Hernandez | Wandy Rodriguez | Wandy Rodriguez | Livan Hernandez | Brad Lidge | 437 | 459 | -22 |
| 2005-08-11 | @ HOU | 114 | L 3-6 | 59-55 | 4 | 35,036 | Ryan Drese | Andy Pettitte | Andy Pettitte | Ryan Drese | | 440 | 465 | -25 |
| 2005-08-12 | @ COL | 115 | W 4-2 | 60-55 | 3 | 28,598 | Esteban Loaiza | Jamey Wright | Esteban Loaiza | Jamey Wright | Chad Cordero | 444 | 467 | -23 |
| 2005-08-13 | @ COL | 116 | W 8-0 | 61-55 | 3 | 31,447 | Tony Armas | Byung-Hyun Kim | Tony Armas | Byung-Hyun Kim | | 452 | 467 | -15 |
| 2005-08-14 | @ COL | 117 | W 9-2 | 62-55 | 3 | 24,552 | John Patterson | Jose Acevedo | John Patterson | Jose Acevedo | | 461 | 469 | -8 |
| 2005-08-15 | @ PHI | 118 | W 6-3 | 63-55 | 2 | 40,627 | Livan Hernandez | Brett Myers | Livan Hernandez | Brett Myers | | 467 | 472 | -5 |
| 2005-08-17 | @ PHI | 119 | L 3-4 | 63-56 | 3 | 33,450 | Esteban Loaiza | Jon Lieber | Jon Lieber | Esteban Loaiza | Billy Wagner | 470 | 476 | -6 |
| 2005-08-18 | @ PHI | 120 | L 1-2 | 64-57 | 3 | 30,046 | Tony Armas | Vicente Padilla | Vicente Padilla | Tony Armas | Billy Wagner | 471 | 478 | -7 |
| 2005-08-18 | @ PHI | 121 | W 5-4 | 64-57 | 3 | 34,492 | Ryan Drese | Cory Lidle | Luis Ayala | Ugueth Urbina | Chad Cordero | 476 | 482 | -6 |
| 2005-08-19 | @ NYN | 122 | L 0-1 | 64-58 | 4 | 38,196 | John Patterson | Jae Weong Seo | Jae Weong Seo | John Patterson | Braden Looper | 476 | 483 | -7 |
| 2005-08-20 | @ NYN | 123 | L 8-9 | 64-59 | 4 | 51,785 | Livan Hernandez | Pedro Martinez | Roberto Hernandez | Gary Majewski | | 484 | 492 | -8 |
| 2005-08-21 | @ NYN | 124 | W 7-4 | 65-59 | 4 | 42,412 | Esteban Loaiza | Kris Benson | Esteban Loaiza | Kris Benson | | 491 | 496 | -5 |
| 2005-08-23 | vs CIN | 125 | L 2-6 | 65-60 | 5 | 35,656 | Tony Armas | Luke Hudson | Luke Hudson | Tony Armas | | 493 | 502 | -9 |
| 2005-08-24 | vs CIN | 126 | W 5-3 | 66-60 | 5 | 32,641 | John Patterson | Ramon Ortiz | John Patterson | Ramon Ortiz | Chad Cordero | 498 | 505 | -7 |
| 2005-08-25 | vs CIN | 127 | L 3-5 | 66-61 | 5 | 40,762 | Livan Hernandez | Brandon Claussen | Brandon Claussen | Livan Hernandez | David Weathers | 501 | 510 | -9 |
| 2005-08-26 | vs SLN | 128 | W 4-1 | 67-61 | 5 | 37,885 | Esteban Loaiza | Jeff Suppan | Esteban Loaiza | Jeff Suppan | Chad Cordero | 505 | 511 | -6 |
| 2005-08-27 | vs SLN | 129 | L 0-6 | 67-62 | 5 | 44,254 | Matt White | Jason Marquis | Jason Marquis | Matt White | | 505 | 517 | -12 |
| 2005-08-28 | vs SLN | 130 | L 0-6 | 67-63 | 5 | 41,130 | John Halama | Cal Eldred | Brad Thompson | John Halama | | 505 | 523 | -18 |
| 2005-08-30 | @ ATL | 131 | W 3-2 | 68-63 | 5 | 20,001 | John Patterson | Jorge Sosa | Jason Bergmann | Jorge Sosa | Chad Cordero | 508 | 525 | -17 |
| 2005-08-31 | @ ATL | 132 | L 3-5 | 69-64 | 5 | 0 | Esteban Loaiza | Horacio Ramirez | Horacio Ramirez | Esteban Loaiza | Kyle Farnsworth | 511 | 530 | -19 |
| 2005-08-31 | @ ATL | 133 | W 4-3 | 69-64 | 5 | 25,555 | Livan Hernandez | John Thomson | Mike Stanton | Chris Reitsma | Chad Cordero | 515 | 533 | -18 |
| 2005-09-01 | @ ATL | 134 | L 7-8 | 69-65 | 5 | 19,053 | Tony Armas | John Smoltz | Kyle Davies | Luis Ayala | | 522 | 541 | -19 |
| 2005-09-02 | vs PHI | 135 | L 1-7 | 69-66 | 5 | 28,939 | John Halama | Vicente Padilla | Vicente Padilla | John Halama | | 523 | 548 | -25 |
| 2005-09-03 | vs PHI | 136 | W 5-4 | 70-66 | 4 | 30,561 | John Patterson | Eude Brito | Hector Carrasco | Aquilino Lopez | | 528 | 552 | -24 |
| 2005-09-04 | vs PHI | 137 | W 6-1 | 71-66 | 4 | 32,251 | Esteban Loaiza | Gavin Floyd | Esteban Loaiza | Gavin Floyd | | 534 | 553 | -19 |
| 2005-09-05 | vs FLO | 138 | W 5-2 | 72-66 | 4 | 32,150 | Livan Hernandez | Jason Vargas | Livan Hernandez | Jason Vargas | | 539 | 555 | -16 |
| 2005-09-06 | vs FLO | 139 | L 2-4 | 72-67 | 4 | 24,936 | Darrell Rasner | Ismael Valdez | Ismael Valdez | Darrell Rasner | Todd Jones | 541 | 559 | -18 |
| 2005-09-07 | vs FLO | 140 | L 1-12 | 72-68 | 4 | 25,702 | John Halama | Dontrelle Willis | Dontrelle Willis | John Halama | | 542 | 571 | -29 |
| 2005-09-08 | vs FLO | 141 | L 4-8 | 72-69 | 4 | 27,625 | John Patterson | Josh Beckett | Josh Beckett | John Patterson | | 546 | 579 | -33 |
| 2005-09-09 | vs ATL | 142 | W 8-6 | 73-69 | 4 | 36,295 | Esteban Loaiza | Horacio Ramirez | Gary Majewski | John Foster | Chad Cordero | 554 | 585 | -31 |
| 2005-09-10 | vs ATL | 143 | L 0-4 | 73-70 | 4 | 44,083 | Livan Hernandez | Jorge Sosa | Jorge Sosa | Livan Hernandez | | 554 | 589 | -35 |
| 2005-09-11 | vs ATL | 144 | L 7-9 | 73-71 | 4 | 31,834 | Jason Bergmann | John Smoltz | Macay McBride | Chad Cordero | Kyle Farnsworth | 561 | 598 | -37 |
| 2005-09-13 | @ NYN | 145 | W 4-2 | 74-71 | 4 | 34,143 | Hector Carrasco | Tom Glavine | Gary Majewski | Tom Glavine | Chad Cordero | 565 | 600 | -35 |
| 2005-09-14 | @ NYN | 146 | W 6-3 | 75-71 | 4 | 24,049 | Esteban Loaiza | Kris Benson | Esteban Loaiza | Kris Benson | Chad Cordero | 571 | 603 | -32 |
| 2005-09-15 | @ NYN | 147 | W 6-5 | 76-71 | 4 | 21,441 | Livan Hernandez | Jae Weong Seo | Jason Bergmann | Roberto Hernandez | Gary Majewski | 577 | 608 | -31 |
| 2005-09-16 | @ SDN | 148 | W 5-1 | 77-71 | 4 | 38,480 | John Patterson | Jake Peavy | John Patterson | Jake Peavy | | 582 | 609 | -27 |
| 2005-09-17 | @ SDN | 149 | L 5-8 | 77-72 | 4 | 37,707 | Hector Carrasco | Adam Eaton | Scott Linebrink | Jon Rauch | | 587 | 617 | -30 |
| 2005-09-18 | @ SDN | 150 | L 1-2 | 77-73 | 4 | 38,054 | Esteban Loaiza | Pedro Astacio | Akinori Otsuka | Joey Eischen | | 588 | 619 | -31 |
| 2005-09-20 | vs SFN | 151 | L 3-4 | 77-74 | 4 | 32,403 | Livan Hernandez | Matt Cain | Jack Taschner | Livan Hernandez | Armando Benitez | 591 | 623 | -32 |
| 2005-09-21 | vs SFN | 152 | L 1-5 | 77-75 | 4 | 32,076 | John Patterson | Brad Hennessey | Brad Hennessey | John Patterson | Armando Benitez | 592 | 628 | -36 |
| 2005-09-22 | vs SFN | 153 | W 2-0 | 78-75 | 4 | 29,807 | Hector Carrasco | Brett Tomko | Jon Rauch | Brett Tomko | Chad Cordero | 594 | 628 | -34 |
| 2005-09-23 | vs NYN | 154 | L 2-5 | 78-76 | 4 | 30,194 | Esteban Loaiza | Steve Trachsel | Roberto Hernandez | Gary Majewski | Aaron Heilman | 596 | 633 | -37 |
| 2005-09-24 | vs NYN | 155 | L 2-5 | 78-77 | 4 | 32,467 | Livan Hernandez | Tom Glavine | Tom Glavine | Livan Hernandez | Roberto Hernandez | 598 | 638 | -40 |
| 2005-09-25 | vs NYN | 156 | L 5-6 | 78-78 | 5 | 29,967 | John Patterson | Kris Benson | Juan Padilla | Travis Hughes | Aaron Heilman | 603 | 644 | -41 |
| 2005-09-26 | @ FLO | 157 | W 4-0 | 79-78 | 5 | 11,467 | Hector Carrasco | Jason Vargas | Hector Carrasco | Jason Vargas | | 607 | 644 | -37 |
| 2005-09-27 | @ FLO | 158 | W 11-1 | 80-78 | 5 | 11,507 | Jon Rauch | Dontrelle Willis | Mike Stanton | Dontrelle Willis | | 618 | 645 | -27 |
| 2005-09-28 | @ FLO | 159 | W 11-7 | 81-78 | 3 | 11,961 | Esteban Loaiza | Brian Moehler | Esteban Loaiza | Brian Moehler | | 629 | 652 | -23 |
| 2005-09-30 | vs PHI | 160 | L 3-4 | 81-79 | 5 | 30,375 | Livan Hernandez | Cory Lidle | Cory Lidle | Livan Hernandez | Billy Wagner | 632 | 656 | -24 |
| 2005-10-01 | vs PHI | 161 | L 4-8 | 81-80 | 5 | 32,903 | John Patterson | Brett Myers | Brett Myers | John Patterson | | 636 | 664 | -28 |
| 2005-10-02 | vs PHI | 162 | L 3-9 | 81-81 | 5 | 36,491 | Hector Carrasco | Jon Lieber | Jon Lieber | Hector Carrasco | Billy Wagner | 639 | 673 | -34 |