| 2005-04-05 | @ FLO | 1 | L 0-9 | 0-1 | 3 | 57,405 | John Smoltz | Josh Beckett | Josh Beckett | John Smoltz | | 0 | 9 | -9 |
| 2005-04-06 | @ FLO | 2 | W 2-1 | 1-1 | 1 | 20,317 | Mike Hampton | Al Leiter | Adam Bernero | Nate Bump | Danny Kolb | 2 | 10 | -8 |
| 2005-04-07 | @ FLO | 3 | W 4-2 | 2-1 | 1 | 19,108 | Tim Hudson | A.J. Burnett | Tim Hudson | A.J. Burnett | Danny Kolb | 6 | 12 | -6 |
| 2005-04-08 | vs NYN | 4 | W 3-1 | 3-1 | 1 | 50,939 | John Thomson | Victor Zambrano | John Thomson | Victor Zambrano | Danny Kolb | 9 | 13 | -4 |
| 2005-04-09 | vs NYN | 5 | W 6-3 | 4-1 | 1 | 40,604 | Horacio Ramirez | Aaron Heilman | Adam Bernero | Aaron Heilman | | 15 | 16 | -1 |
| 2005-04-10 | vs NYN | 6 | L 1-6 | 4-2 | 1 | 36,601 | John Smoltz | Pedro Martinez | Pedro Martinez | John Smoltz | | 16 | 22 | -6 |
| 2005-04-11 | vs WAS | 7 | W 11-2 | 5-2 | 1 | 16,584 | Mike Hampton | Zach Day | Mike Hampton | Zach Day | | 27 | 24 | 3 |
| 2005-04-12 | vs WAS | 8 | L 3-4 | 5-3 | 1 | 20,122 | Tim Hudson | Esteban Loaiza | Luis Ayala | Danny Kolb | Chad Cordero | 30 | 28 | 2 |
| 2005-04-13 | vs WAS | 9 | L 4-11 | 5-4 | 1 | 19,093 | John Thomson | Tomo Ohka | Tomo Ohka | John Thomson | | 34 | 39 | -5 |
| 2005-04-15 | @ PHI | 10 | W 11-4 | 6-4 | 1 | 31,408 | Horacio Ramirez | Gavin Floyd | Horacio Ramirez | Gavin Floyd | | 45 | 43 | 2 |
| 2005-04-16 | @ PHI | 11 | L 1-2 | 6-5 | 2 | 36,820 | John Smoltz | Jon Lieber | Jon Lieber | John Smoltz | Billy Wagner | 46 | 45 | 1 |
| 2005-04-17 | @ PHI | 12 | L 1-2 | 6-6 | 2 | 32,008 | Mike Hampton | Brett Myers | Ryan Madson | Danny Kolb | | 47 | 47 | 0 |
| 2005-04-18 | @ HOU | 13 | W 1-0 | 7-6 | 2 | 31,672 | Tim Hudson | Roger Clemens | Jorge Sosa | Dan Wheeler | Danny Kolb | 48 | 47 | 1 |
| 2005-04-19 | @ HOU | 14 | L 3-5 | 7-7 | 3 | 32,146 | John Thomson | Brandon Backe | Brandon Backe | John Thomson | Brad Lidge | 51 | 52 | -1 |
| 2005-04-20 | @ WAS | 15 | L 0-2 | 7-8 | 3 | 27,374 | Horacio Ramirez | Zach Day | Zach Day | Horacio Ramirez | Chad Cordero | 51 | 54 | -3 |
| 2005-04-21 | @ WAS | 16 | W 2-1 | 8-8 | 3 | 30,728 | John Smoltz | John Patterson | Chris Reitsma | Chad Cordero | Danny Kolb | 53 | 55 | -2 |
| 2005-04-22 | vs PHI | 17 | W 6-2 | 9-8 | 2 | 26,837 | Mike Hampton | Brett Myers | Mike Hampton | Brett Myers | Danny Kolb | 59 | 57 | 2 |
| 2005-04-23 | vs PHI | 18 | W 11-1 | 10-8 | 2 | 31,656 | Tim Hudson | Randy Wolf | Tim Hudson | Randy Wolf | | 70 | 58 | 12 |
| 2005-04-24 | vs PHI | 19 | W 4-0 | 11-8 | 1 | 26,713 | John Thomson | Vicente Padilla | John Thomson | Vicente Padilla | | 74 | 58 | 16 |
| 2005-04-25 | @ NYN | 20 | L 4-5 | 11-9 | 2 | 16,874 | Horacio Ramirez | Aaron Heilman | Aaron Heilman | Horacio Ramirez | Braden Looper | 78 | 63 | 15 |
| 2005-04-26 | @ NYN | 21 | W 4-3 | 12-9 | 2 | 31,511 | John Smoltz | Pedro Martinez | John Smoltz | Pedro Martinez | John Foster | 82 | 66 | 16 |
| 2005-04-27 | @ NYN | 22 | W 8-4 | 13-9 | 2 | 21,087 | Mike Hampton | Tom Glavine | Mike Hampton | Tom Glavine | | 90 | 70 | 20 |
| 2005-04-29 | vs SLN | 23 | L 5-6 | 13-10 | 2 | 33,833 | Tim Hudson | Mark Mulder | Mark Mulder | Tim Hudson | Alberto Reyes | 95 | 76 | 19 |
| 2005-04-30 | vs SLN | 24 | W 3-2 | 14-10 | 2 | 35,789 | John Thomson | Matt Morris | Danny Kolb | Jimmy Journell | | 98 | 78 | 20 |
| 2005-05-01 | vs SLN | 25 | W 2-1 | 15-10 | 2 | 34,304 | John Smoltz | Jeff Suppan | John Smoltz | Jeff Suppan | Danny Kolb | 100 | 79 | 21 |
| 2005-05-03 | vs FLO | 26 | L 6-11 | 15-11 | 2 | 22,299 | Mike Hampton | Al Leiter | Al Leiter | Mike Hampton | | 106 | 90 | 16 |
| 2005-05-04 | vs FLO | 27 | W 5-2 | 16-11 | 2 | 25,082 | Tim Hudson | A.J. Burnett | Tim Hudson | A.J. Burnett | Danny Kolb | 111 | 92 | 19 |
| 2005-05-05 | vs HOU | 28 | W 9-3 | 17-11 | 1 | 20,553 | John Thomson | Brandon Backe | John Thomson | Brandon Backe | | 120 | 95 | 25 |
| 2005-05-06 | vs HOU | 29 | W 9-4 | 18-11 | 1 | 26,987 | John Smoltz | Roy Oswalt | John Smoltz | Roy Oswalt | | 129 | 99 | 30 |
| 2005-05-07 | vs HOU | 30 | W 4-1 | 19-11 | 1 | 36,452 | Horacio Ramirez | Andy Pettitte | Horacio Ramirez | Andy Pettitte | Danny Kolb | 133 | 100 | 33 |
| 2005-05-08 | vs HOU | 31 | W 16-0 | 20-11 | 1 | 32,498 | Mike Hampton | Ezequiel Astacio | Mike Hampton | Ezequiel Astacio | | 149 | 100 | 49 |
| 2005-05-09 | @ COL | 32 | L 6-7 | 20-12 | 1 | 20,307 | Tim Hudson | Jamey Wright | Jamey Wright | Tim Hudson | Chin-hui Tsao | 155 | 107 | 48 |
| 2005-05-10 | @ COL | 33 | W 9-5 | 21-12 | 1 | 20,415 | John Thomson | Jason Jennings | Jorge Sosa | Jason Jennings | | 164 | 112 | 52 |
| 2005-05-11 | @ COL | 34 | L 5-6 | 21-13 | 1 | 19,631 | John Smoltz | Byung-Hyun Kim | Chin-hui Tsao | Danny Kolb | | 169 | 118 | 51 |
| 2005-05-13 | @ LAN | 35 | L 4-7 | 21-14 | 1 | 53,689 | Horacio Ramirez | Jeff Weaver | Giovanni Carrara | Chris Reitsma | Yhency Brazoban | 173 | 125 | 48 |
| 2005-05-14 | @ LAN | 36 | W 5-1 | 22-14 | 1 | 49,112 | Mike Hampton | Odalis Perez | Adam Bernero | Odalis Perez | | 178 | 126 | 52 |
| 2005-05-15 | @ LAN | 37 | W 5-2 | 23-14 | 1 | 53,239 | Tim Hudson | Scott Erickson | Tim Hudson | Wilson Alvarez | Danny Kolb | 183 | 128 | 55 |
| 2005-05-16 | @ SDN | 38 | L 3-5 | 23-15 | 1 | 25,958 | John Thomson | Tim Stauffer | Scott Linebrink | Chris Reitsma | Trevor Hoffman | 186 | 133 | 53 |
| 2005-05-17 | @ SDN | 39 | L 2-3 | 23-16 | 1 | 31,330 | John Smoltz | Darrell May | Dennys Reyes | Danny Kolb | | 188 | 136 | 52 |
| 2005-05-18 | @ SDN | 40 | L 4-8 | 23-17 | 1 | 31,670 | Horacio Ramirez | Adam Eaton | Adam Eaton | Horacio Ramirez | Trevor Hoffman | 192 | 144 | 48 |
| 2005-05-20 | @ BOS | 41 | L 3-4 | 23-18 | 2 | 35,332 | Tim Hudson | Wade Miller | Wade Miller | Tim Hudson | Keith Foulke | 195 | 148 | 47 |
| 2005-05-21 | @ BOS | 42 | W 7-5 | 24-18 | 2 | 35,008 | Kyle Davies | Tim Wakefield | Kyle Davies | Tim Wakefield | | 202 | 153 | 49 |
| 2005-05-22 | @ BOS | 43 | L 2-5 | 24-19 | 2 | 34,844 | John Smoltz | Matt Clement | Matt Clement | Roman Colon | | 204 | 158 | 46 |
| 2005-05-23 | vs NYN | 44 | W 8-6 | 25-19 | 2 | 26,132 | Horacio Ramirez | Kazuhisa Ishii | Horacio Ramirez | Kazuhisa Ishii | Danny Kolb | 212 | 164 | 48 |
| 2005-05-24 | vs NYN | 45 | W 4-0 | 26-19 | 2 | 28,927 | Tim Hudson | Tom Glavine | Tim Hudson | Tom Glavine | | 216 | 164 | 52 |
| 2005-05-25 | vs NYN | 46 | W 3-0 | 27-19 | 2 | 33,250 | Kyle Davies | Victor Zambrano | Kyle Davies | Victor Zambrano | Chris Reitsma | 219 | 164 | 55 |
| 2005-05-27 | vs PHI | 47 | L 1-5 | 27-20 | 2 | 31,501 | John Smoltz | Cory Lidle | Cory Lidle | John Smoltz | | 220 | 169 | 51 |
| 2005-05-28 | vs PHI | 48 | L 5-12 | 27-21 | 2 | 34,975 | Horacio Ramirez | Jon Lieber | Jon Lieber | Horacio Ramirez | | 225 | 181 | 44 |
| 2005-05-29 | vs PHI | 49 | W 7-2 | 28-21 | 2 | 37,615 | Tim Hudson | Brett Myers | Tim Hudson | Brett Myers | | 232 | 183 | 49 |
| 2005-05-30 | @ WAS | 50 | L 2-3 | 28-22 | 2 | 39,705 | Kyle Davies | Tomo Ohka | Tomo Ohka | Kyle Davies | Chad Cordero | 234 | 186 | 48 |
| 2005-05-31 | @ WAS | 51 | L 4-5 | 28-23 | 2 | 29,512 | Mike Hampton | John Patterson | Luis Ayala | Roman Colon | Chad Cordero | 238 | 191 | 47 |
| 2005-06-01 | @ WAS | 52 | W 5-4 | 29-23 | 1 | 28,280 | John Smoltz | Tony Armas | John Smoltz | Hector Carrasco | Chris Reitsma | 243 | 195 | 48 |
| 2005-06-02 | @ WAS | 53 | L 6-8 | 29-24 | 2 | 29,225 | Horacio Ramirez | Esteban Loaiza | Hector Carrasco | Danny Kolb | Chad Cordero | 249 | 203 | 46 |
| 2005-06-03 | @ PIT | 54 | L 1-3 | 29-25 | 2 | 27,643 | Tim Hudson | Kip Wells | Kip Wells | Tim Hudson | Jose Mesa | 250 | 206 | 44 |
| 2005-06-04 | @ PIT | 55 | W 1-0 | 30-25 | 1 | 33,649 | Kyle Davies | Mark Redman | John Foster | Mike Gonzalez | Chris Reitsma | 251 | 206 | 45 |
| 2005-06-05 | @ PIT | 56 | L 2-5 | 30-26 | 2 | 28,717 | Seth Greisinger | Oliver Perez | Oliver Perez | Adam Bernero | Jose Mesa | 253 | 211 | 42 |
| 2005-06-06 | vs ANA | 57 | L 2-4 | 30-27 | 2 | 23,104 | John Smoltz | John Lackey | Brendan Donnelly | John Smoltz | Francisco Rodriguez | 255 | 215 | 40 |
| 2005-06-07 | vs ANA | 58 | W 3-2 | 31-27 | 2 | 25,276 | Horacio Ramirez | Paul Byrd | Horacio Ramirez | Paul Byrd | Chris Reitsma | 258 | 217 | 41 |
| 2005-06-08 | vs ANA | 59 | L 4-8 | 31-28 | 3 | 27,747 | Tim Hudson | Kelvim Escobar | Brendan Donnelly | John Foster | | 262 | 225 | 37 |
| 2005-06-10 | vs OAK | 60 | L 4-6 | 31-29 | 4 | 28,535 | Kyle Davies | Dan Haren | Dan Haren | Roman Colon | Huston Street | 266 | 231 | 35 |
| 2005-06-11 | vs OAK | 61 | W 5-3 | 32-29 | 4 | 36,004 | John Smoltz | Kirk Saarloos | John Smoltz | Justin Duchscherer | | 271 | 234 | 37 |
| 2005-06-12 | vs OAK | 62 | L 5-11 | 32-30 | 4 | 27,819 | Horacio Ramirez | Barry Zito | Barry Zito | Blaine Boyer | | 276 | 245 | 31 |
| 2005-06-13 | @ TEX | 63 | L 3-7 | 32-31 | 4 | 41,594 | Tim Hudson | Chris Young | Chris Young | Tim Hudson | | 279 | 252 | 27 |
| 2005-06-14 | @ TEX | 64 | W 7-2 | 33-31 | 4 | 30,221 | Jorge Sosa | Pedro Astacio | Jorge Sosa | Pedro Astacio | | 286 | 254 | 32 |
| 2005-06-15 | @ TEX | 65 | L 5-9 | 33-32 | 4 | 33,663 | Kyle Davies | Chan Ho Park | Chan Ho Park | Kyle Davies | Francisco Cordero | 291 | 263 | 28 |
| 2005-06-16 | @ CIN | 66 | W 5-2 | 34-32 | 4 | 23,362 | John Smoltz | Brandon Claussen | John Smoltz | Brandon Claussen | Chris Reitsma | 296 | 265 | 31 |
| 2005-06-17 | @ CIN | 67 | W 10-5 | 35-32 | 3 | 27,023 | Horacio Ramirez | Ramon Ortiz | Horacio Ramirez | Ramon Ortiz | | 306 | 270 | 36 |
| 2005-06-18 | @ CIN | 68 | W 6-1 | 36-32 | 3 | 41,737 | Jorge Sosa | Eric Milton | Adam Bernero | Eric Milton | | 312 | 271 | 41 |
| 2005-06-19 | @ CIN | 69 | L 8-11 | 36-33 | 3 | 28,836 | Kyle Davies | Luke Hudson | David Weathers | Adam Bernero | | 320 | 282 | 38 |
| 2005-06-21 | vs FLO | 70 | W 5-0 | 37-33 | 3 | 28,686 | John Smoltz | A.J. Burnett | John Smoltz | A.J. Burnett | | 325 | 282 | 43 |
| 2005-06-22 | vs FLO | 71 | W 8-0 | 38-33 | 3 | 30,216 | Horacio Ramirez | Brian Moehler | Horacio Ramirez | Brian Moehler | | 333 | 282 | 51 |
| 2005-06-23 | vs FLO | 72 | L 0-8 | 38-34 | 3 | 29,826 | Jorge Sosa | Dontrelle Willis | Dontrelle Willis | Jorge Sosa | | 333 | 290 | 43 |
| 2005-06-24 | vs BAL | 73 | W 7-5 | 39-34 | 2 | 43,822 | Kyle Davies | Hayden Penn | Kyle Davies | Hayden Penn | Chris Reitsma | 340 | 295 | 45 |
| 2005-06-25 | vs BAL | 74 | W 5-4 | 40-34 | 2 | 44,106 | Roman Colon | Bruce Chen | Jorge Vasquez | Todd Williams | | 345 | 299 | 46 |
| 2005-06-26 | vs BAL | 75 | W 8-1 | 41-34 | 2 | 37,157 | John Smoltz | Rodrigo Lopez | John Smoltz | Rodrigo Lopez | | 353 | 300 | 53 |
| 2005-06-27 | @ FLO | 76 | W 7-2 | 42-34 | 2 | 16,341 | Horacio Ramirez | Brian Moehler | Horacio Ramirez | Brian Moehler | | 360 | 302 | 58 |
| 2005-06-28 | @ FLO | 77 | W 9-1 | 43-34 | 2 | 20,129 | Jorge Sosa | Dontrelle Willis | Jorge Sosa | Dontrelle Willis | | 369 | 303 | 66 |
| 2005-06-29 | @ FLO | 78 | L 5-6 | 43-35 | 2 | 23,512 | Kyle Davies | Al Leiter | John Riedling | Adam Bernero | | 374 | 309 | 65 |
| 2005-06-30 | @ FLO | 79 | L 2-6 | 43-36 | 2 | 23,147 | Roman Colon | Josh Beckett | Josh Beckett | Roman Colon | | 376 | 315 | 61 |
| 2005-07-01 | @ PHI | 80 | W 9-1 | 44-36 | 2 | 45,004 | John Smoltz | Vicente Padilla | John Smoltz | Vicente Padilla | | 385 | 316 | 69 |
| 2005-07-02 | @ PHI | 81 | L 3-6 | 44-37 | 2 | 29,205 | Horacio Ramirez | Brett Myers | Brett Myers | Horacio Ramirez | Billy Wagner | 388 | 322 | 66 |
| 2005-07-03 | @ PHI | 82 | W 4-3 | 45-37 | 2 | 39,732 | Jorge Sosa | Rob Tejeda | Jim Brower | Billy Wagner | Chris Reitsma | 392 | 325 | 67 |
| 2005-07-04 | vs CHN | 83 | W 4-0 | 46-37 | 2 | 52,274 | Kyle Davies | Kerry Wood | Kyle Davies | Kerry Wood | | 396 | 325 | 71 |
| 2005-07-05 | vs CHN | 84 | W 5-1 | 47-37 | 2 | 34,698 | Roman Colon | Greg Maddux | Roman Colon | Greg Maddux | | 401 | 326 | 75 |
| 2005-07-07 | vs CHN | 85 | W 6-0 | 49-37 | 2 | 32,711 | Horacio Ramirez | Mark Prior | Horacio Ramirez | Mark Prior | | 407 | 326 | 81 |
| 2005-07-07 | vs CHN | 86 | W 9-4 | 49-37 | 2 | 34,847 | John Smoltz | Jerome Williams | John Foster | Roberto Novoa | | 416 | 330 | 86 |
| 2005-07-08 | vs MIL | 87 | W 2-1 | 50-37 | 2 | 29,402 | Jorge Sosa | Doug Davis | Danny Kolb | Julio Santana | | 418 | 331 | 87 |
| 2005-07-09 | vs MIL | 88 | L 6-9 | 50-38 | 2 | 40,514 | Kyle Davies | Ben Sheets | Ben Sheets | Kyle Davies | | 424 | 340 | 84 |
| 2005-07-10 | vs MIL | 89 | L 4-8 | 50-39 | 2 | 24,916 | Roman Colon | Chris Capuano | Chris Capuano | Roman Colon | | 428 | 348 | 80 |
| 2005-07-14 | @ NYN | 90 | L 3-6 | 50-40 | 2 | 43,319 | Horacio Ramirez | Kris Benson | Roberto Hernandez | Jim Brower | Braden Looper | 431 | 354 | 77 |
| 2005-07-15 | @ NYN | 91 | W 2-1 | 51-40 | 2 | 34,444 | John Smoltz | Tom Glavine | John Smoltz | Roberto Hernandez | Chris Reitsma | 433 | 355 | 78 |
| 2005-07-16 | @ NYN | 92 | W 3-0 | 52-40 | 2 | 36,078 | Tim Hudson | Victor Zambrano | Tim Hudson | Victor Zambrano | Chris Reitsma | 436 | 355 | 81 |
| 2005-07-17 | @ NYN | 93 | L 1-8 | 52-41 | 2 | 34,983 | Mike Hampton | Pedro Martinez | Pedro Martinez | Mike Hampton | | 437 | 363 | 74 |
| 2005-07-18 | @ SFN | 94 | W 6-1 | 53-41 | 2 | 42,277 | Jorge Sosa | Kevin Correia | Jorge Sosa | Kevin Correia | | 443 | 364 | 79 |
| 2005-07-19 | @ SFN | 95 | L 4-5 | 53-42 | 2 | 42,494 | Horacio Ramirez | Jason Schmidt | Tyler Walker | Danny Kolb | | 447 | 369 | 78 |
| 2005-07-20 | @ SFN | 96 | W 4-1 | 54-42 | 2 | 42,371 | John Smoltz | Noah Lowry | John Smoltz | Noah Lowry | Chris Reitsma | 451 | 370 | 81 |
| 2005-07-22 | @ ARI | 97 | L 5-6 | 54-43 | 1 | 27,348 | Tim Hudson | Claudio Vargas | Lance Cormier | Jim Brower | | 456 | 376 | 80 |
| 2005-07-23 | @ ARI | 98 | W 3-2 | 55-43 | 1 | 32,673 | Jorge Sosa | Brad Halsey | Chris Reitsma | Jose Valverde | | 459 | 378 | 81 |
| 2005-07-24 | @ ARI | 99 | L 2-3 | 55-44 | 1 | 30,280 | Horacio Ramirez | Javier Vazquez | Javier Vazquez | Horacio Ramirez | Brian Bruney | 461 | 381 | 80 |
| 2005-07-26 | vs WAS | 100 | W 3-2 | 56-44 | 1 | 43,308 | John Smoltz | Livan Hernandez | Chris Reitsma | Mike Stanton | | 464 | 383 | 81 |
| 2005-07-27 | vs WAS | 101 | W 4-3 | 57-44 | 1 | 40,625 | Tim Hudson | Esteban Loaiza | Danny Kolb | Gary Majewski | Chris Reitsma | 468 | 386 | 82 |
| 2005-07-28 | vs WAS | 102 | W 5-4 | 58-44 | 1 | 40,269 | Jorge Sosa | Ryan Drese | Jorge Sosa | Ryan Drese | Chris Reitsma | 473 | 390 | 83 |
| 2005-07-29 | vs PIT | 103 | W 2-1 | 59-44 | 1 | 36,767 | Horacio Ramirez | David Williams | Horacio Ramirez | David Williams | Macay McBride | 475 | 391 | 84 |
| 2005-07-30 | vs PIT | 104 | W 9-6 | 60-44 | 1 | 47,441 | Kyle Davies | Mark Redman | Kyle Davies | Mark Redman | Chris Reitsma | 484 | 397 | 87 |
| 2005-07-31 | vs PIT | 105 | W 5-4 | 61-44 | 1 | 33,275 | John Smoltz | Josh Fogg | John Smoltz | John Grabow | Chris Reitsma | 489 | 401 | 88 |
| 2005-08-01 | vs PIT | 106 | L 1-4 | 61-45 | 1 | 25,875 | Tim Hudson | Zach Duke | Zach Duke | Tim Hudson | Jose Mesa | 490 | 405 | 85 |
| 2005-08-02 | @ CIN | 107 | W 12-2 | 62-45 | 1 | 25,680 | Jorge Sosa | Ramon Ortiz | Jorge Sosa | Ramon Ortiz | | 502 | 407 | 95 |
| 2005-08-03 | @ CIN | 108 | L 5-8 | 62-46 | 1 | 37,157 | Horacio Ramirez | Brandon Claussen | Brandon Claussen | Horacio Ramirez | Kent Mercker | 507 | 415 | 92 |
| 2005-08-04 | @ CIN | 109 | W 7-4 | 63-46 | 1 | 23,285 | Kyle Davies | Aaron Harang | Kyle Davies | Aaron Harang | Chris Reitsma | 514 | 419 | 95 |
| 2005-08-05 | @ SLN | 110 | L 3-11 | 63-47 | 1 | 47,838 | John Smoltz | Mark Mulder | Mark Mulder | John Smoltz | | 517 | 430 | 87 |
| 2005-08-06 | @ SLN | 111 | W 8-1 | 64-47 | 1 | 48,565 | Tim Hudson | Jason Marquis | Tim Hudson | Jason Marquis | | 525 | 431 | 94 |
| 2005-08-07 | @ SLN | 112 | L 3-5 | 64-48 | 1 | 47,714 | Jorge Sosa | Chris Carpenter | Ray King | Chris Reitsma | | 528 | 436 | 92 |
| 2005-08-09 | vs SFN | 113 | W 7-1 | 65-48 | 1 | 27,230 | Horacio Ramirez | Brad Hennessey | Horacio Ramirez | Brad Hennessey | | 535 | 437 | 98 |
| 2005-08-10 | vs SFN | 114 | W 5-4 | 66-48 | 1 | 24,032 | John Smoltz | Kevin Correia | Blaine Boyer | Brian Cooper | | 540 | 441 | 99 |
| 2005-08-11 | vs SFN | 115 | L 3-5 | 66-49 | 1 | 26,577 | Tim Hudson | Jason Schmidt | Jason Schmidt | Tim Hudson | Tyler Walker | 543 | 446 | 97 |
| 2005-08-12 | vs ARI | 116 | L 0-8 | 66-50 | 1 | 32,006 | Jorge Sosa | Claudio Vargas | Claudio Vargas | Jorge Sosa | | 543 | 454 | 89 |
| 2005-08-13 | vs ARI | 117 | W 9-5 | 67-50 | 1 | 36,817 | John Thomson | Russ Ortiz | John Foster | Lance Cormier | | 552 | 459 | 93 |
| 2005-08-14 | vs ARI | 118 | W 13-8 | 68-50 | 1 | 30,098 | Mike Hampton | Javier Vazquez | Mike Hampton | Javier Vazquez | | 565 | 467 | 98 |
| 2005-08-16 | vs LAN | 119 | L 4-6 | 68-51 | 1 | 24,692 | John Smoltz | Derek Lowe | Giovanni Carrara | Chris Reitsma | Duaner Sanchez | 569 | 473 | 96 |
| 2005-08-17 | vs LAN | 120 | W 10-2 | 69-51 | 1 | 23,028 | Tim Hudson | Odalis Perez | Tim Hudson | Odalis Perez | | 579 | 475 | 104 |
| 2005-08-18 | vs LAN | 121 | L 4-7 | 69-52 | 1 | 24,101 | John Thomson | Jeff Weaver | Jeff Weaver | John Thomson | Duaner Sanchez | 583 | 482 | 101 |
| 2005-08-19 | vs SDN | 122 | L 7-12 | 69-53 | 1 | 35,071 | Mike Hampton | Chan Ho Park | Chan Ho Park | Mike Hampton | | 590 | 494 | 96 |
| 2005-08-20 | vs SDN | 123 | L 2-7 | 69-54 | 1 | 37,133 | Horacio Ramirez | Pedro Astacio | Rudy Seanez | Joey Devine | | 592 | 501 | 91 |
| 2005-08-21 | vs SDN | 124 | W 6-2 | 70-54 | 1 | 26,077 | John Smoltz | Brian Lawrence | Jorge Sosa | Akinori Otsuka | | 598 | 503 | 95 |
| 2005-08-22 | @ CHN | 125 | W 4-2 | 71-54 | 1 | 38,767 | Tim Hudson | Carlos Zambrano | Tim Hudson | Kerry Wood | | 602 | 505 | 97 |
| 2005-08-23 | @ CHN | 126 | L 1-10 | 71-55 | 1 | 38,273 | John Thomson | Jerome Williams | Jerome Williams | John Thomson | | 603 | 515 | 88 |
| 2005-08-24 | @ CHN | 127 | W 3-1 | 72-55 | 1 | 38,033 | Jorge Sosa | Mark Prior | Jorge Sosa | Mark Prior | Kyle Farnsworth | 606 | 516 | 90 |
| 2005-08-26 | @ MIL | 128 | L 1-3 | 72-56 | 1 | 30,670 | Horacio Ramirez | Ben Sheets | Ben Sheets | Horacio Ramirez | Derrick Turnbow | 607 | 519 | 88 |
| 2005-08-27 | @ MIL | 129 | W 8-4 | 73-56 | 1 | 42,464 | John Smoltz | Rick Helling | John Smoltz | Victor Santos | | 615 | 523 | 92 |
| 2005-08-28 | @ MIL | 130 | W 5-2 | 74-56 | 1 | 35,060 | Tim Hudson | Chris Capuano | Tim Hudson | Chris Capuano | | 620 | 525 | 95 |
| 2005-08-30 | vs WAS | 131 | L 2-3 | 74-57 | 1 | 20,001 | Jorge Sosa | John Patterson | Jason Bergmann | Jorge Sosa | Chad Cordero | 622 | 528 | 94 |
| 2005-08-31 | vs WAS | 132 | W 5-3 | 75-58 | 1 | 0 | Horacio Ramirez | Esteban Loaiza | Horacio Ramirez | Esteban Loaiza | Kyle Farnsworth | 627 | 531 | 96 |
| 2005-08-31 | vs WAS | 133 | L 3-4 | 75-58 | 1 | 25,555 | John Thomson | Livan Hernandez | Mike Stanton | Chris Reitsma | Chad Cordero | 630 | 535 | 95 |
| 2005-09-01 | vs WAS | 134 | W 8-7 | 76-58 | 1 | 19,053 | John Smoltz | Tony Armas | Kyle Davies | Luis Ayala | | 638 | 542 | 96 |
| 2005-09-02 | vs CIN | 135 | W 7-4 | 77-58 | 1 | 27,041 | Tim Hudson | Eric Milton | Tim Hudson | Eric Milton | Kyle Farnsworth | 645 | 546 | 99 |
| 2005-09-03 | vs CIN | 136 | W 9-3 | 78-58 | 1 | 40,212 | Jorge Sosa | Luke Hudson | Jorge Sosa | Luke Hudson | | 654 | 549 | 105 |
| 2005-09-04 | vs CIN | 137 | L 3-8 | 78-59 | 1 | 34,472 | Horacio Ramirez | Ramon Ortiz | Matt Belisle | Danny Kolb | | 657 | 557 | 100 |
| 2005-09-05 | vs NYN | 138 | W 4-2 | 79-59 | 1 | 33,045 | John Thomson | Steve Trachsel | Blaine Boyer | Steve Trachsel | Kyle Farnsworth | 661 | 559 | 102 |
| 2005-09-06 | vs NYN | 139 | W 3-1 | 80-59 | 1 | 21,068 | John Smoltz | Pedro Martinez | John Smoltz | Pedro Martinez | Kyle Farnsworth | 664 | 560 | 104 |
| 2005-09-07 | vs NYN | 140 | W 4-3 | 81-59 | 1 | 28,564 | Tim Hudson | Tom Glavine | John Foster | Braden Looper | | 668 | 563 | 105 |
| 2005-09-09 | @ WAS | 141 | L 6-8 | 81-60 | 1 | 36,295 | Horacio Ramirez | Esteban Loaiza | Gary Majewski | John Foster | Chad Cordero | 674 | 571 | 103 |
| 2005-09-10 | @ WAS | 142 | W 4-0 | 82-60 | 1 | 44,083 | Jorge Sosa | Livan Hernandez | Jorge Sosa | Livan Hernandez | | 678 | 571 | 107 |
| 2005-09-11 | @ WAS | 143 | W 9-7 | 83-60 | 1 | 31,834 | John Smoltz | Jason Bergmann | Macay McBride | Chad Cordero | Kyle Farnsworth | 687 | 578 | 109 |
| 2005-09-12 | @ PHI | 144 | L 1-4 | 83-61 | 1 | 21,169 | Tim Hudson | Eude Brito | Eude Brito | Tim Hudson | Billy Wagner | 688 | 582 | 106 |
| 2005-09-13 | @ PHI | 145 | L 4-5 | 83-62 | 1 | 24,311 | John Thomson | Gavin Floyd | Aaron Fultz | Blaine Boyer | Billy Wagner | 692 | 587 | 105 |
| 2005-09-14 | @ PHI | 146 | L 4-12 | 83-63 | 1 | 23,125 | Horacio Ramirez | Cory Lidle | Cory Lidle | Horacio Ramirez | | 696 | 599 | 97 |
| 2005-09-15 | @ PHI | 147 | W 6-4 | 84-63 | 1 | 27,804 | Jorge Sosa | Brett Myers | Jorge Sosa | Brett Myers | Kyle Farnsworth | 702 | 603 | 99 |
| 2005-09-16 | @ NYN | 148 | L 0-4 | 84-64 | 1 | 37,519 | John Smoltz | Pedro Martinez | Pedro Martinez | John Smoltz | | 702 | 607 | 95 |
| 2005-09-17 | @ NYN | 149 | W 7-4 | 85-64 | 1 | 34,191 | Tim Hudson | Steve Trachsel | Tim Hudson | Steve Trachsel | Kyle Farnsworth | 709 | 611 | 98 |
| 2005-09-18 | @ NYN | 150 | L 1-4 | 85-65 | 1 | 31,703 | John Thomson | Tom Glavine | Tom Glavine | John Thomson | | 710 | 615 | 95 |
| 2005-09-20 | vs PHI | 151 | W 4-1 | 86-65 | 1 | 25,701 | Jorge Sosa | Cory Lidle | Jorge Sosa | Cory Lidle | | 714 | 616 | 98 |
| 2005-09-21 | vs PHI | 152 | L 6-10 | 86-66 | 1 | 27,030 | Horacio Ramirez | Brett Myers | Geoff Geary | Kyle Davies | | 720 | 626 | 94 |
| 2005-09-22 | vs PHI | 153 | L 0-4 | 86-67 | 1 | 26,301 | Tim Hudson | Jon Lieber | Jon Lieber | Tim Hudson | | 720 | 630 | 90 |
| 2005-09-23 | vs FLO | 154 | W 4-3 | 87-67 | 1 | 39,076 | John Smoltz | Josh Beckett | Blaine Boyer | Todd Jones | Kyle Farnsworth | 724 | 633 | 91 |
| 2005-09-24 | vs FLO | 155 | W 6-1 | 88-67 | 1 | 51,775 | John Thomson | Brian Moehler | John Thomson | Brian Moehler | | 730 | 634 | 96 |
| 2005-09-25 | vs FLO | 156 | W 5-3 | 89-67 | 1 | 48,147 | Jorge Sosa | A.J. Burnett | Blaine Boyer | A.J. Burnett | Kyle Farnsworth | 735 | 637 | 98 |
| 2005-09-26 | vs COL | 157 | L 5-6 | 89-68 | 1 | 23,788 | Horacio Ramirez | Mike Esposito | Ryan Speier | Chris Reitsma | Brian Fuentes | 740 | 643 | 97 |
| 2005-09-27 | vs COL | 158 | W 12-3 | 90-68 | 1 | 25,306 | Tim Hudson | Aaron Cook | Tim Hudson | Aaron Cook | | 752 | 646 | 106 |
| 2005-09-28 | vs COL | 159 | L 5-10 | 90-69 | 1 | 29,971 | Kyle Davies | Jeff Francis | Jeff Francis | Kyle Davies | | 757 | 656 | 101 |
| 2005-09-30 | @ FLO | 160 | L 2-5 | 90-70 | 1 | 25,461 | John Thomson | Josh Johnson | Ron Villone | John Thomson | Todd Jones | 759 | 661 | 98 |
| 2005-10-01 | @ FLO | 161 | L 4-6 | 90-71 | 1 | 28,392 | Jorge Sosa | Jason Vargas | Chris Resop | Danny Kolb | Todd Jones | 763 | 667 | 96 |
| 2005-10-02 | @ FLO | 162 | L 6-7 | 90-72 | 1 | 29,214 | Horacio Ramirez | Dontrelle Willis | Ron Villone | Kyle Davies | | 769 | 674 | 95 |